Medicine and Health Sciences Commons^™

Xenon In The Treatment Of Panic Disorder: An Open Label Study., Alexander Dobrovolsky, Thomas E Ichim, Daqing Ma, Santosh Kesari, Vladimir Bogin

Articles, Abstracts, and Reports

BACKGROUND: Current treatments of panic disorder (PD) are limited by adverse effects, poor efficacy, and need for chronic administration. The established safety profile of subanesthetic concentrations of xenon gas, which is known to act as a glutamate subtype NMDA receptor antagonist, coupled with preclinical studies demonstrating its effects in other anxiety related conditions, prompted us to evaluate its feasibility and efficacy in treatment of patients with PD.

METHODS: An open-label clinical trial of xenon-oxygen mixture was conducted in 81 patients with PD; group 1 consisting of patients only with PD (N = 42); and group 2 patients with PD and …

Self-Reported Racial/Ethnic Discrimination And Bronchodilator Response In African American Youth With Asthma, Sonia Carlson, Luisa N. Borrell, Celeste Eng, Myngoc Nguyen, Shannon Thyne, Michael A. Lenoir, Nadine Burke-Harris, Esteban G. Burchard, Neeta Thakur

Publications and Research

Importance Asthma is a multifactorial disease composed of endotypes with varying risk profiles and outcomes. African Americans experience a high burden of asthma and of psychosocial stress, including racial discrimination. It is unknown which endotypes of asthma are vulnerable to racial/ethnic discrimination.

Objective We examined the association between self-reported racial/ethnic discrimination and bronchodilator response (BDR) among African American youth with asthma ages 8 to 21 years (n = 576) and whether this association varies with tumor necrosis factor alpha (TNF-α) level.

Materials and methods Self-reported racial/ethnic discrimination was assessed by a modified Experiences of Discrimination questionnaire as none or any. …

Subcutaneous Neurotophin 4 Infusion Using Osmotic Pumps Or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles, Richard D. Andreatta, Joseph C. Stemple, Tanya S. Seward, Colleen A. Mcmullen

Physical Therapy Faculty Publications

Laryngeal dysfunction in the elderly is a major cause of disability, from voice disorders to dysphagia and loss of airway protective reflexes. Few, if any, therapies exist that target age-related laryngeal muscle dysfunction. Neurotrophins are involved in muscle innervation and differentiation of neuromuscular junctions (NMJs). It is thought that neurotrophins enhance neuromuscular transmission by increasing neurotransmitter release. The neuromuscular junctions (NMJs) become smaller and less abundant in aging rat laryngeal muscles, with evidence of functional denervation. We explored the effects of NTF4 for future clinical use as a therapeutic to improve function in aging human laryngeal muscles. Here, we provide …

Presurgical Thalamic "Hubness" Predicts Surgical Outcome In Temporal Lobe Epilepsy., Xiaosong He, Gaelle E. Doucet, Dorian Pustina, Michael R. Sperling, Ashwini D. Sharan, Joseph I. Tracy

Department of Neurology Faculty Papers

OBJECTIVE: To characterize the presurgical brain functional architecture presented in patients with temporal lobe epilepsy (TLE) using graph theoretical measures of resting-state fMRI data and to test its association with surgical outcome.

METHODS: Fifty-six unilateral patients with TLE, who subsequently underwent anterior temporal lobectomy and were classified as obtaining a seizure-free (Engel class I, n = 35) vs not seizure-free (Engel classes II-IV, n = 21) outcome at 1 year after surgery, and 28 matched healthy controls were enrolled. On the basis of their presurgical resting-state functional connectivity, network properties, including nodal hubness (importance of a node to the network; …

Presynaptic Lrp4 Promotes Synapse Number And Function Of Excitatory Cns Neurons., Timothy J. Mosca, David J. Luginbuhl, Irving E. Wang, Liqun Luo

Department of Neuroscience Faculty Papers

Precise coordination of synaptic connections ensures proper information flow within circuits. The activity of presynaptic organizing molecules signaling to downstream pathways is essential for such coordination, though such entities remain incompletely known. We show that LRP4, a conserved transmembrane protein known for its postsynaptic roles, functions presynaptically as an organizing molecule. In the Drosophila brain, LRP4 localizes to the nerve terminals at or near active zones. Loss of presynaptic LRP4 reduces excitatory (not inhibitory) synapse number, impairs active zone architecture, and abolishes olfactory attraction - the latter of which can be suppressed by reducing presynaptic GABAB receptors. LRP4 overexpression increases …

Elevated Dietary Magnesium During Pregnancy And Postnatal Life Prevents Ectopic Mineralization In Enpp1asj Mice, A Model For Generalized Arterial Calcification Of Infancy., Joshua Kingman, Jouni Uitto, Qiaoli Li

Department of Dermatology and Cutaneous Biology Faculty Papers

Generalized arterial calcification of infancy (GACI) is an autosomal recessive disorder caused by mutations in the ENPP1 gene. It is characterized by mineralization of the arterial blood vessels, often diagnosed prenatally, and associated with death in early childhood. There is no effective treatment for this devastating disorder. We previously characterized the Enpp1asjmutant mouse as a model of GACI, and we have now explored the effect of elevated dietary magnesium (five-fold) in pregnant mothers and continuing for the first 14 weeks of postnatal life. The mothers were kept on either control diet or experimental diet supplemented with magnesium. Upon weaning at …

Exploring The Long-Term Effects Of Domestic Violence In Art Therapy Treatment, Ekaterini Angelis

LMU Theses and Dissertations

This qualitative case study explores the long-term effects of domestic violence through the lens of art therapy treatment. The study is based on a twelve-week long art therapy treatment group for women who have experienced domestic violence. The study includes a literature review and a qualitative analysis of the participants’ artwork and details of their experiences of domestic violence related trauma. The research focuses on two participants and utilizes textual and visual analysis to identify four emergent themes: Family and identity, hope in moving forward, support and connection, and freedom. The findings discuss the value of art therapy in revealing …

An Exploration Of Trauma Markers In The Artwork Of Serial Killers, Kiran M. Haynes

LMU Theses and Dissertations

This research is a qualitative art-based study exploring trauma markers found in the artwork of serial killers through the participation of licensed art therapists trained in the identification and treatment of trauma. The literature review covers a broad range of variables that influence the development of mass murderers, and how art therapy may be useful in working with serial killer populations. The study offers a unique, non-verbal exploration of the trauma experienced by serial killers through the art therapy lens. The three participants provided invaluable data through their responses to a questionnaire and creation of response art that demonstrates evidence …

La Crisis Ignorada, Joseph Pokorski

Best Integrated Writing

Pokorski researched the food production practices of pre-Columbian civilizations. He uses his research to evaluate the current food production practices of transnational corporations and offers suggestions for best practices.

An Interdisciplinary Analysis Of Medical Tourism, Tanner L. Hudson

Best Integrated Writing

Hudson presents the emerging trend of medical tourism and discusses the personal, logistical, ethical, and economic implications of this trend. Hudson advises consumers to observe caution and thoroughly research all treatment options.

Trans* Suicide: The Final Option, Alexander Oxner

Best Integrated Writing

Oxner researched the factors involved in the high rate of trans* suicide. Oxner determined that a strong social support system might reduce these high rates.

Best Integrated Writing 2017 - Complete Edition

Best Integrated Writing

Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University. The journal is published annually by the Wright State University Department of English Language and Literatures.

Determining The Longitudinal Validity And Meaningful Differences In Hrql Of The Pedsql™ Sickle Cell Disease Module., Julie A Panepinto, J Paul Scott, Oluwakemi Badaki-Makun, Deepika S Darbari, Corrie E Chumpitazi, Gladstone E Airewele, +Several Additional Authors

Pediatrics Faculty Publications

BACKGROUND: Detecting change in health status over time and ascertaining meaningful changes are critical elements when using health-related quality of life (HRQL) instruments to measure patient-centered outcomes. The PedsQL™ Sickle Cell Disease module, a disease specific HRQL instrument, has previously been shown to be valid and reliable. Our objectives were to determine the longitudinal validity of the PedsQL™ Sickle Cell Disease module and the change in HRQL that is meaningful to patients.

METHODS: An ancillary study was conducted utilizing a multi-center prospective trial design. Children ages 4-21 years with sickle cell disease admitted to the hospital for an acute painful …

Critical Care Nurses’ Stories Of Eol Care Obstacles, Robin Grigg, Beckstrand Renea

Journal of Undergraduate Research

The purpose of this project was to discover critical care nurses’ perspectives of obstacles in providing end-of-life (EOL) care to patients. Because 20% of Americans die in an Intensive Care Unit (ICU) (CDC, 2011), EOL care is a vital component of critical care nursing. Therefore, discerning and overcoming obstacles to EOL care is necessary in order for critical care nurses to provide quality EOL care. Additionally, The National Institute of Nursing Research’s strategic plan lists five areas of focus, the third being EOL care, emphasizing the need for EOL care research (NINR, 2014).

The Added Value Of Spect/Ct In Endocrinology: A Pictorial Essay, Cheryl Rickley, Cnmt, Michele Barasch, Cnmt, Charles Intenzo, Md, Sung Kim, Md

Department of Radiology Posters

Objective:

Dedicated radionuclide imaging of the spleen in useful in conditions such as accessory spleen and splenic trauma. Nuclear Medicine plays a key role in the diagnostic molecular SPECT/CT imaging of splenic disorders.

Poster presented at SNMMI Annual Conference in Denver Colorado, United States.

Get Moving: Motivating Sedentary Young Adults, Rebecca Edmunds, Neil Peterson

Journal of Undergraduate Research

Obesity and sedentary behavior are increasing in the United States and the world. On the Centers for Disease Control and Prevention (CDC) website recent statistics put over one third of the American adult population as obese and over half as overweight (2015). This epidemic has contributed to a drastic increase in disease and cost. Obesity and the accompanying diseases are not only expensive to treat but also decrease quality of life. Prevention is essential. Many companies are working to find devices that help motivate people and encourage physical activity and a healthy lifestyle. This research project focused specifically on the …

Immunization Rates Of Nicu Infants, Emily Gardner, Janelle Macintosh

Journal of Undergraduate Research

The goal of this project was to determine the vaccination rates of infants in the Neonatal Intensive Care Unit (NICU) of various hospitals throughout the Wasatch Front in Utah. We collected data related to possible reasons why infants may not receive their immunizations during their stay at the facility. Many are uninformed of the recommendation from the American Academy of Pediatrics (AAP) which states that that preterm and low birth weight babies should receive all immunizations at the same chronological age as full term infants. Yet, many pre term infants fail to be immunized. Preterm infants are at an increased …

What's Happening: June 12, 2017, Maine Medical Center

What's Happening

No abstract provided.

Optimal Radionuclide Imaging Of Splenic Disorders: The Value Of Spect/Ct, Cheryl Rickley, Cnmt, Michele Barasch, Cnmt, Charles Intenzo, Md, Sung Kim, Md

Department of Radiology Posters

Objective:

Dedicated radionuclide imaging of the spleen in useful in conditions such as accessory spleen and splenic trauma. Nuclear Medicine plays a key role in the diagnostic molecular SPECT/CT imaging of splenic disorders.

Poster presented at Society of Nuclear Medicine Molecular Imagining in Denver Colorado, United States.

Meaning Of Childbirth For Hmong Women In Vietnam, Jamie Gettys, Cheryl Corbett

Journal of Undergraduate Research

The basis of this research project comes from data collected on a BYU Anthropology field school in Vietnam during the summer of 2015. The data consisted of eight in-depth interviews with Hmong women who had given birth within the last eighteen months. The focus of the interviews was on their experience giving birth and what that experience meant to them. The purpose of this research is to educate healthcare providers on the perceptions of the Hmong women interviewed so as to better accommodate to their preferences.

05-09-2017 Hsc Committee Meeting Minutes, Patrice Martin

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

An Exploration Of Nurse Educators' Knowledge, Attitudes And Practice Of Horizontal Violence Measured Through Dimensions Of Oppression, Brenda Berner Petersen

Seton Hall University Dissertations and Theses (ETDs)

There is a paradox in the profession of nursing. Although nursing is known as the caring profession, evidence demonstrates that nurses do not care well for their own. Literature demonstrates that the phenomenon of horizontal violence (HV) is an international problem in the nursing profession, which negatively affects the nurse workplace environment. HV is broadly described as aggressive destructive behavior and intergroup conflict that occurs between nurses. Where behaviors of HV exist, the workplace becomes a toxic environment or nurses (Woefle & McCaffrey, 2007).

This dissertation provides the results of a research study exploring nurse educator’s knowledge, attitudes and practices …

African American Men's Prostate Cancer Knowledge And Self-Efficacy For Informed Decision-Making: A Mixed Methods Study, Dionne J. Jones-Dendy Phd

Nursing Theses and Dissertations

A mixed methods study was conducted whereby, the quantitative portion has a randomized control design, in an urban Delaware community to examine the effectiveness of an educational intervention, which included the testimony of an African American (AA) prostate cancer survivor on AA men’s (n=98) prostate cancer knowledge and self-efficacy for informed decision making. Guided by Bandura’s Social Cognitive theory, participants’ prostate cancer knowledge measured by PROCASE and for self-efficacy measured by the Prostate Cancer Screening Self-efficacy scale, were evaluated before and following viewing of the American Cancer Society’s prostate cancer video. Participants randomized to the intervention completed evaluations after the …

Impact Of Hpv Education On Knowledge, Perception, And Cultural Influence Among African American Parents, Christina Lattner

College of Science and Health Theses and Dissertations

Background: Infection with human papillomavirus (HPV), the sexually transmitted virus that causes cervical and penial cancer can be prevented. An effective vaccine has been approved for both boys and girls since 2006. Despite recommendation from the Center of Disease Control, vaccination initiation and completion rates among African American adolescents in the United States are lower than average in the nation.

Objectives: The purpose of this descriptive survey study was to identify African-American parents’ knowledge and perceptions of sexually transmitted HPV infection and the HPV vaccination. The secondary objective was to use a single-group pre-test post-test research design to examine …

Education Program Using Non-Pharmacologic Support During Benzodiazepine Reduction In Patients With Anxiety Disorders, Kelly D. Kearney Dnp, Rn, Pmhnp-Bc, Diane Wardell Phd, Whnp-Bc

Journal of Nursing & Interprofessional Leadership in Quality & Safety

A private mental health clinic developed an initiative to aid patients with anxiety disorders to taper their use of benzodiazepines. Based on best practices, a treatment protocol was developed in which patients attended 4 sessions (1 per month) in which they combined instruction in non-pharmaceutical anti-anxiety techniques (guided imagery, mindfulness meditation, deep breathing, progressive muscle relaxation, exercise, emotional freedom) with cognitive behavioral therapy and use of selective serotonin re uptake inhibitors. Participants experienced a reduction in benzodiazepine use. This small scale initiative showed that the holistic approach to anxiety management was an effective plan to decrease the use of benzodiazepines …

A Case-Based Review Of The Management Of Penetrating Brain Trauma., Jason Milton, Alex Rugino, Kailash Narayan, Chris Karas, Victor Awuor

Trauma and Acute Care Articles

Principles of penetrating head trauma management were established by Harvey Cushing in relation to the management of penetrating brain injuries of World War One. Cushing radically debrided the scalp and skull and aggressively irrigated wound tracks to remove foreign bodies. He would then obtain water-tight closure. Cushing significantly decreased infection rates which reportedly limited the major cause of mortality due to penetrating head injuries. Many advances have been made by contributions from World War Two, Korean War, Vietnam War, and Iran/Iraq conflicts. Early radical decompression, with conservative debridement and duraplasty applied to blast-induced penetrating injuries during Operation Iraqi Freedom, has …

Diabetes Screening And Prevention In A High-Risk, Medically Isolated Border Community, Ann V. Millard, Margaret A. Graham, Nelda Mier, Jesus Moralez, Maria Perez-Patron, Brian Wickwire, Marlynn L. May, Marcia G. Ory

Anthropology Faculty Publications

Introduction: A project in a Texas border community setting, Prevention Organized against Diabetes and Dialysis with Education and Resources (POD2ER), offered diabetes prevention information, screening, and medical referrals. The setting was a large, longstanding flea market that functions as a shopping mall for low-income people. The priority population included medically underserved urban and rural Mexican Americans. Components of the program addressed those with diabetes, prediabetes, and accompanying relatives and friends.

Background: People living in the Lower Rio Grande Valley (LRGV) face challenges of high rates of type 2 diabetes, lack of knowledge about prevention, and inadequate access to medical care. …

The Healer’S Art Learning History, Lisa Cowan-Echols, Bret Lyman

Journal of Undergraduate Research

A primary purpose of this study was to discover new insights related to organizational learning in a college of nursing that may guide nursing faculty and administrators as they strive to improve outcomes in their own colleges.

Organizational learning is highly context-dependent process through which organizations progress toward achieving their desired outcomes. For a college of nursing, desired outcomes may relate to student achievement, faculty productivity, leadership in the profession, etc. Although organizational learning has been studied in a variety of business and industrial settings, it has not been studied in colleges of nursing. Understanding organizational learning in colleges of …

Electronic Health Records And Patient Safeety: Nurse Practitioners’ Experiences In Clinical Practice, Lindsay Dixon, Karen Whitt

Journal of Undergraduate Research

The purpose of this project was to evaluate practicing nurse practitioners’ experiences and satisfaction with electronic health records (EHRs). In response to health policy initiatives and incentives, many healthcare organizations in the U.S. have recently implemented EHRs in clinical practice. Despite expectations that EHRs can improve patient safety, there is evidence that EHRs have the potential to contribute to adverse patient events and medical errors. Therefore, an urgent need to improve the safety of EHRs has been recognized. In June 2015, a study was conducted by Dr. Karen Whitt that invited nurse practitioners to share their experiences and satisfaction with …

Effects Of Poverty Simulation: Perceptions Of Medical Sociology Students, Mike Mcneil, Gaye Ray, Rn, Ms, Fnp-C

Journal of Undergraduate Research

Poverty affects 46.7 million people in the United States. The U.S. Census data show that poverty rates have increased 2.3% from 2007 to 2014 (DeNevas-Walt and Proctor, 2015). It is shown that poverty has become a major social determinant of health. Beckles (2011) states that the socioeconomic circumstances of individuals and the places where they live and work strongly influence their health. In the United States, the risk for mortality, morbidity, unhealthy behaviors, reduced access to healthcare, and poor quality of care increases with decreasing socioeconomic circumstances. Evidence indicates that students benefit remarkably from classroom and clinical learning experience in …