Medicine and Health Sciences Commons^™

Degenerative Changes Of The Canine Cervical Spine After Discectomy Procedures, An In Vivo Study., Peter Grunert, Yu Moriguchi, Brian P Grossbard, Rodolfo J Ricart Arbona, Lawrence J Bonassar, Roger Härtl

Articles, Abstracts, and Reports

BACKGROUND: Discectomies are a common surgical treatment for disc herniations in the canine spine. However, the effect of these procedures on intervertebral disc tissue is not fully understood. The objective of this study was to assess degenerative changes of cervical spinal segments undergoing discectomy procedures, in vivo.

RESULTS: Discectomies led to a 60% drop in disc height and 24% drop in foraminal height. Segments did not fuse but showed osteophyte formation as well as endplate sclerosis. MR imaging revealed terminal degenerative changes with collapse of the disc space and loss of T2 signal intensity. The endplates showed degenerative type II …

Sex After Gray Hair? Association Between Sexual Activity, Hugging, And Health Among Older Adults?, Chantelle Sharpe

USF Tampa Graduate Theses and Dissertations

Research on sexual behavior in late life is limited but is growing. Despite ageist stereotypes associating old age with asexuality, older adults continue to desire and engage in sexual behavior. Previous studies have examined the relationship between health and the ability to engage in sexual behavior, sexual satisfaction, desire, or interest in sex. Research has yet to examine the potential reverse of this relationship, where sexual behavior may serve as a protective factor against health outcomes.

This dissertation examined three research questions to test the relationship between sexual activity or hugging and self-reported health outcomes (e.g., arthritis and diabetes) and …

A Microrna Signature Of Response To Erlotinib Is Descriptive Of Tgfβ Behaviour In Nsclc, Madeline J. Krentz Gober, James P. Collard, Katherine L. Thompson, Esther P. Black

Pharmaceutical Sciences Faculty Publications

Our previous work identified a 13-gene miRNA signature predictive of response to the epidermal growth factor receptor (EGFR) inhibitor, erlotinib, in Non-Small Cell Lung Cancer cell lines. Bioinformatic analysis of the signature showed a functional convergence on TGFβ canonical signalling. We hypothesized that TGFβ signalling controls expression of the miRNA genes comprising an erlotinib response signature in NSCLC. Western analysis revealed that TGFβ signalling via Smad2/3/4 occurred differently between erlotinib-resistant A549 and erlotinib- sensitive PC9 cells. We showed that TGFβ induced an interaction between Smad4 and putative Smad Binding Elements in PC9. However, qRT-PCR analysis showed that endogenous miR-140/141/200c expression …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern Examines Increasing Breastfeeding Duration and Exclusivity in Rural Women

Increasing Cell Density Globally Enhances The Biogenesis Of Piwi-Interacting Rnas In Bombyx Mori Germ Cells., Shozo Honda, Phillipe Loher, Keisuke Morichika, Megumi Shigematsu, Takuya Kawamura, Yoriko Kirino, Isidore Rigoutsos, Yohei Kirino

Computational Medicine Center Faculty Papers

Piwi proteins and their bound Piwi-interacting RNAs (piRNAs) are predominantly expressed in the germline and play crucial roles in germline development by silencing transposons and other targets. Bombyx mori BmN4 cells are culturable germ cells that equip the piRNA pathway. Because of the scarcity of piRNA-expressing culturable cells, BmN4 cells are being utilized for the analyses of piRNA biogenesis. We here report that the piRNA biogenesis in BmN4 cells is regulated by cell density. As cell density increased, the abundance of Piwi proteins and piRNA biogenesis factors was commonly upregulated, resulting in an increased number of perinuclear nuage-like granules where …

Hairy Tongue, Marc Zachary Handler, David F. Butler, Drore Eisen, Jeff Burgess, Denis P. Lynch, Gary L. Stafford

School of Dentistry Faculty Research and Publications

Hairy tongue (lingua villosa) is a commonly observed condition of defective desquamation of the filiform papillae that results from a variety of precipitating factors. ^[1] The condition is most frequently referred to as black hairy tongue (lingua villosa nigra); however, hairy tongue may also appear brown, white, green, pink, or any of a variety of hues depending on the specific etiology and secondary factors (eg, use of colored mouthwashes, breath mints, candies). ^{[2, 3]} See the images below:

Effects Of Steep Trendelenburg Positioning On Intraocular Pressure, Grace K. Hauschild

Nursing Capstones

No abstract provided.

The Indirect Efficacy Comparison Of Dna Methylation In Sputum For Early Screening And Auxiliary Detection Of Lung Cancer: A Meta-Analysis, Di Liu, Hongli Peng, Qi Sun, Zhongyoa Zhao, Xinwei Yu, Siqi Ge, Hao Wang, Honghong Fang, Qing Gao, Jiaonan Liu, Lijuan Wu, Manshu Song, Youxin Wang

Research outputs 2014 to 2021

Background

DNA methylation in sputum has been an attractive candidate biomarker for the non-invasive screening and detection of lung cancer.

Materials and Methods

Databases including PubMed, Ovid, Cochrane library, Web of Science databases, Chinese Biological Medicine (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang, Vip Databases and Google Scholar were searched to collect the diagnostic trials on aberrant DNA methylation in the screening and detection of lung cancer published until 1 December 2016. Indirect comparison meta-analysis was used to evaluate the diagnostic value of the included candidate genes.

Results

The systematic literature search yielded a total of 33 studies including a …

Assessing Medical Student Knowledge And Attitudes About Shared Decision Making Across The Curriculum: Protocol For An International Online Survey And Stakeholder Analysis, Marie-Anne Durand, Renata Yen, Paul J. Barr, Nan Cochran, Johanna Aarts, France Legare, Malcolm Reed, A. James O'Malley, Peter Scalia, Genevieve Painchaud Guérard, Glyn Elwyn

Dartmouth Scholarship

INTRODUCTION:

Shared decision making (SDM) is a goal of modern medicine; however, it is not currently embedded in routine care. Barriers include clinicians attitudes, lack of knowledge and training and time constraints. Our goal is to support the development and delivery of a robust SDM curriculum in medical education. Our objective is to assess undergraduate medical students knowledge of and attitudes towards SDM in four countries.

METHODS AND ANALYSIS:

The first phase of the study involves a web-based cross-sectional survey of undergraduate medical students from all years in selected schools across the United States (US), Canada and undergraduate and graduate …

Establishment Of An Orthotopic Patient-Derived Xenograft Mouse Model Using Uveal Melanoma Hepatic Metastasis., Ken Kageyama, Masahiro Ohara, Kengo Saito, Shinji Ozaki, Mizue Terai, Michael J. Mastrangelo, Paolo Fortina, Andrew E. Aplin, Takami Sato

Department of Medical Oncology Faculty Papers

BACKGROUND: Metastatic uveal melanoma is a highly fatal disease; most patients die from their hepatic metastasis within 1 year. A major drawback in the development of new treatments for metastatic uveal melanoma is the difficulty in obtaining appropriate cell lines and the lack of appropriate animal models. Patient-derived xenograft (PDX) tumor models, bearing ectopically implanted tumors at a subcutaneous site, have been developed. However, these ectopically implanted PDX models have obstacles to translational research, including a low engraftment rate, slow tumor growth, and biological changes after multiple passages due to the different microenvironment. To overcome these limitations, we developed a …

Research Brief: "Mental Health Of Transgender Veterans Of The Iraq And Afghanistan Conflicts Who Experienced Military Sexual Trauma", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This brief is about the relationship between identifying as a transgender veteran, military sexual trauma, and mental health disorders. In policy and practice, transgender veterans who have experienced military sexual trauma should discuss the trauma history with a mental health provider, and health care providers should work with transgender veterans to connect them with proper counseling services. The DoD should work to reduce gender identity stigma within the military and the VA should research MST treatment effectiveness among transgender veterans. Suggestions for future research include using self-rated identity as a variable and determining more about the effectiveness of MST treatments …

Community Health News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Georgia Southern Examines Increasing Breastfeeding Duration and Exclusivity in Rural Women

Ability Of Physiological Strain Index To Discriminate Between Sustainable And Unsustainable Heat Stress, Dwayne Wilson

USF Tampa Graduate Theses and Dissertations

Introduction: Assessment of heat strain is an alternative approach to assessing heat stress exposures. Two common measures of heat strain are body core temperature (T_C) and heart rate (HR). In this study TC was assessed by rectal temperature (T_re). Physiological Strain Index (PSI) was developed to combine both T_re and HR into one metric. Data collected from progressive heat stress trials were used to (1) demonstrate that PSI can distinguish between Sustainable and Unsustainable heat stress; (2) suggest values for PSI that demonstrate a sustainable level of heat stress; and (3) determine if clothing or …

The Effect Of Antigen Polymorphisms On Serological Antibody Detection Assays Based Upon The, Kristi M. Miley

USF Tampa Graduate Theses and Dissertations

Onchocerca volvulus is a filarial parasite transmitted to humans by female Simulium spp. black flies. Infection with this parasite can cause blindness and severe skin disease among humans in Africa and the Americas. Enzyme-linked Immunosorbent Assay serological testing of OV-16 antigen is a diagnostic tool for determining effective elimination of the parasite. Programs typically rely on OV–16 ELISA to evaluate the progress towards interruption and/or elimination of disease by mass drug distribution of ivermectin and vector larvicidal control efforts. As elimination grows closer, monoclonal antibody positive controls for OV-16 ELISA become important to develop for Onchocerca testing due to the …

Development Of Bone Targeting Drugs., Molly Stapleton, Kazuki Sawamoto, Carlos J. Alméciga-Díaz, William G. Mackenzie, Robert W. Mason, Tadao Orii, Shunji Tomatsu

Department of Pediatrics Faculty Papers

The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that affect the skeletal system can be difficult to treat, mainly because of the avascular cartilage region. Targeting drugs to the site of action can not only increase efficacy but also reduce toxicity. Bone-targeting drugs are designed with either of two general targeting moieties, aimed at the entire skeletal system or a specific cell type. Most bone-targeting drugs utilize an affinity to hydroxyapatite, a major component of the bone matrix that includes a high concentration of positively-charged Ca(2+). …

Validation Of Accelerometer-Based Energy Expenditure Prediction Models In Structured And Simulated Free-Living Settings, Alexander H. K. Montoye, Scott A. Conger, Christopher P. Connolly, Mary T. Imboden, M. Benjamin Nelson, Josh M. Bock, Leonard A. Kaminsky

Faculty Publications - Department of Kinesiology

This study compared accuracy of energy expenditure (EE) prediction models from accelerometer data collected in structured and simulated free-living settings. Twenty-four adults (mean age 45.8 years, 50% female) performed two sessions of 11 to 21 activities, wearing four ActiGraph GT9X Link activity monitors (right hip, ankle, both wrists) and a metabolic analyzer (EE criterion). Visit 1 (V1) involved structured, 5-min activities dictated by researchers; Visit 2 (V2) allowed participants activity choice and duration (simulated free-living). EE prediction models were developed incorporating data from one setting (V1/V2; V2/V2) or both settings (V1V2/V2). The V1V2/V2 method had the lowest root mean square …

Propofol Administration In Patients With An Egg Allergy, Katie J. King

Nursing Capstones

No abstract provided.

An Interactive, Mobile-Based Tool For Personal Social Network Data Collection And Visualization Among A Geographically Isolated And Socioeconomically Disadvantaged Population: Early-Stage Feasibility Study With Qualitative User Feedback, Katherine S. Eddens, Jesse M. Fagan, Tom Collins

Health, Behavior & Society Faculty Publications

Background: Personal social networks have a profound impact on our health, yet collecting personal network data for use in health communication, behavior change, or translation and dissemination interventions has proved challenging. Recent advances in social network data collection software have reduced the burden of network studies on researchers and respondents alike, yet little testing has occurred to discover whether these methods are: (1) acceptable to a variety of target populations, including those who may have limited experience with technology or limited literacy; and (2) practical in the field, specifically in areas that are geographically and technologically disconnected, such as rural …

Authority And Scope Of Vaccination: How States Differ, Sharon Xavioer, Jeff Goad

Pharmacy Faculty Articles and Research

"Despite all this, vaccine rates still fall short of desirable goals, such as those outlined in the Healthy People 2020 national initiative.⁷ Although the CDC and APhA promote the “immunization neighborhood” concept, meaning all appropriate professions should coordinate, communicate, and collaborate to increase immunization rates, challenges are still evident for pharmacies.⁸ One major factor is the variability in state laws and regulations that govern vaccine administration by pharmacists.⁵ Significant regulation differences limit which vaccines are permitted, which age groups of patients can be immunized, and which practice model pharmacists may operate under.⁹"

Occupational Stress And Increased Risk For Type 2-Diabetes: A Narrative Review, Harrynauth Persaud, Shawn Williams

Publications and Research

Diabetes is a significant health problem in the United States. There is a large body of research that explains the biological and pathoetiological cause(s) of this increasingly prevalent disease. There is also an increasing body of research that explores the psychosocial causes of diabetes mellitus type 2. The association between stressful work organization and diabetes has been established as a significant precursor and causative agent of diabetes mellitus - type 2. The objective of this narrative review is to discuss the impact of work stress as it applies to the rising incidence of diabetes - type 2, and to propose …

Secteur Minier : Approche Intégrée De Mesure De Contraintes In Situ Par Méthode Inverse, Robert Corthésy, Maria Helena Leite, Caroline Vézina, Amélie Ouellet, Hamza Ouziame, Simon Delattre

Rapports de recherche scientifique

La conception sécuritaire des excavations souterraines requises pour l’exploitation minière nécessite une bonne connaissance de l’état des contraintes naturelles du massif rocheux.

À ce jour, la seule façon de connaître ces contraintes avec une justesse acceptable consiste à réaliser des mesures in situ. Or, les techniques de mesure de contraintes couramment utilisées dans les mines du Québec se heurtent à des limites importantes sur le plan de la fiabilité et de la précision, ce qui laisse toujours planer un doute sur la validité des résultats obtenus, exposant par le fait même les travailleurs miniers à des risques potentiels …

Analysis Of A Potential A(H7n9) Influenza Pandemic Outbreak In The U.S., Walter A. Silva Sotillo

USF Tampa Graduate Theses and Dissertations

This dissertation presents a collection of manuscripts that describe development of models and model implementation to analyze impact of potential A(H7N9) pandemic influenza outbreak in the U.S. Though this virus is still only animal-to-human transmittable, it has potential to become human-to-human transmittable and trigger a pandemic. This work is motivated by the negative impact on human lives that this virus has already caused in China, and is intended to support public health officials in preparing to protect U.S. population from a potential outbreak of pandemic scale.

An agent-based (AB) simulation model is used to replicate the social dynamics of the …

Apneic Oxygenation, Scott J. Honkola

Nursing Capstones

No abstract provided.

Immunizations And Health Disparities: Immunizations Provided Across A Diverse Population, Jeffery A. Goad, Tania Gregorian

Pharmacy Faculty Articles and Research

"Vaccines help contain the spread of diseases and reduce morbidity and mortality. For any vaccination effort to succeed, vaccine uptake must be widespread across the entire population. However, the US population is very diverse, and there are various groups with different attitudes and beliefs regarding vaccination; this leads to disparities in vaccination rates. The Healthy People initiative, a program managed by Office of Disease Prevention and Health Promotion at the US Department of Health and Human Services HHS that aims to provide Americans with evidence-based, 10-year national objectives for improving their health defines a disparity in health care as 'a …

Light Exercise Heart Rate On-Kinetics: A Comparison Of Data Fitted With Sigmoidal And Exponential Functions And The Impact Of Fitness And Exercise Intensity, Karl M. Trounson, Spencer Robert, Aaron Balloch

Research outputs 2014 to 2021

This study examined the suitability of sigmoidal (SIG) and exponential (EXP) functions for modeling HR kinetics at the onset of a 5‐min low‐intensity cycling ergometer exercise test (5MT). The effects of training status, absolute and relative workloads, and high versus low workloads on the accuracy and reliability of these functions were also examined. Untrained participants (UT_abs; n = 13) performed 5MTs at 100W. One group of trained participants (n = 10) also performed 5MTs at 100W (ET_abs). Another group of trained participants (n = 9) performed 5MTs at 45% and 60% max (ET_{45 …}

Anemia Of Unknown Origin In An Otherwise Healthy Asa 1 18-Year-Old Male, Andrew Rook

Nursing Capstones

No abstract provided.

What Motivates Young Adults To Talk About Physical Activity On Social Network Sites?, Ni Zhang, Shelly Campo, Jingzhen Yang, Petya Eckler, Linda Snetselaar, Kathleen Janz, Emily Leary

Faculty Research, Scholarly, and Creative Activity

Background:
Electronic word-of-mouth on social network sites has been used successfully in marketing. In social marketing, electronic word-of-mouth about products as health behaviors has the potential to be more effective and reach more young adults than health education through traditional mass media. However, little is known about what motivates people to actively initiate electronic word-of-mouth about health behaviors on their personal pages or profiles on social network sites, thus potentially reaching all their contacts on those sites.
Objective:
This study filled the gap by applying a marketing theoretical model to explore the factors associated with electronic word-of-mouth on social network …

Can We Talk?: Synergistic Effects Of Cognitive And Behavioral Frameworks To Address Substance Use And Abuse, Lauren Jaye Adams

USF Tampa Graduate Theses and Dissertations

Behavioral economic accounts of substance use have provided a novel framework to examine constraints that affect behaviorally driven outcomes. Several behavioral studies support the application of such frameworks to examine impulsive decision-making processes as well as how subjective reward influences substance use. Based on stimulus-response models, behavioral economic research often applies mathematical formulas to draw conclusions about behavioral outcomes. These mathematical formulas, while useful, largely ignore decades of cognitive psychology research that have examined state-based influences (e.g., mood, environment, motivational processes, etc.) on behavioral sequelae. To address this issue, the present study merged a cognitive framework into two behavioral economic …

Exploring Nutritional Needs, Roles, And Expectations Of Latina Breast Cancer Survivors, Pamela Carolina Birriel

USF Tampa Graduate Theses and Dissertations

Latina breast cancer survivors, especially those who have undergone chemotherapy, may face major disruptions to their diet and eating habits; and a major concern is their ability to function in daily life roles throughout survivorship. Food and nutrition are suggested to be significant factors that can influence the process of cancer development, yet little research has been done to understand the nutritional needs, roles, and expectations among Latina breast cancer survivors. The purpose of this study was to understand Latina breast cancer survivors’ perceptions of the role of diet and nutrition in helping them cope with the effect of chemotherapy …

Force Compensation And Recreation Accuracy In Humans, Benjamin Rigsby

USF Tampa Graduate Theses and Dissertations

As industry becomes increasingly reliant on robotic assistance and human-computer interfaces, the demand to understand the human sensorimotor system’s characteristics intensifies. Although this field of research has been going on for over a century, new technologies push the limits of the human motor system and our knowledge of it. With new technologies come new abilities, and, in the area of medical care and rehabilitation, the need to expand our knowledge of the sensorimotor system comes from both the patient and physician.

Two studies relating to human force interaction are presented in this thesis. The first study

focuses on humans’ ability …