Medicine and Health Sciences Commons^™

Nonpharmacologic Interventions And Adjunct Therapies In The Treatment Of Schizophrenia, Katie West

Nursing Capstones

No abstract provided.

Constructing A Reference Framework For Ecep Evaluation: A Constructive Grounded Theory, Shelina Bhamani, Nasreen Husain

Department of Obstetrics & Gynaecology

The purpose of this research study, which is a thesis investigation, was to develop a reference framework that can help program staff to evaluate quality in Early Childhood Education (ECE) settings. The study was approached with three questions. This paper presents the first question of the study that enables practitioners to understand what are the variables that best define quality in early childhood education. The grounded theory, design was approached to explore the experiences of 20 ECE experts in the field. The data analysis revealed eight main indicators, that are, holistic development, interactive teaching, trained practitioners, conducive learning environment, safe …

Posttraumatic Reactions To Psychosis: A Qualitative Analysis, Weili Lu, Kim T. Mueser, Stanley D. Rosenberg, Philip T. Yanos, Neisrein Mahmoud

Publications and Research

The current study aimed to evaluate the potentially traumatic aspects of psychotic symptoms and psychiatric treatment of psychosis using qualitative methods. Participants included 63 people with first episode psychosis or multiple psychotic episodes recruited from an inpatient psychiatric unit and an urban state psychiatric hospital in the North East region of the United States. Quasi-structured interviews were used to explore those aspects of symptoms and treatment that were perceived as traumatic Emotional reactions to the most traumatic aspect of symptoms and treatment, during and after the event, were also examined. Participants described a number of traumatogenic aspects of psychotic symptoms, …

2017 July 18 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Maternal Choline Supplementation Alters Fetal Growth Patterns In A Mouse Model Of Placental Insufficiency, Julia H. King, Sze Ting (Cecilia) Kwan, Jian Yan, Kevin C. Klatt, Xinyin Jiang, Mark S. Roberson, Marie A. Caudill

Publications and Research

Impairments in placental development can adversely affect pregnancy outcomes. The bioactive nutrient choline may mitigate some of these impairments, as suggested by data in humans, animals, and human trophoblasts. Herein, we investigated the effects of maternal choline supplementation (MCS) on parameters of fetal growth in a Dlx3+/− (distal-less homeobox 3) mouse model of placental insufficiency. Dlx3+/− female mice were assigned to 1X (control), 2X, or 4X choline intake levels during gestation. Dams were sacrificed at embryonic days E10.5, 12.5, 15.5, and 18.5. At E10.5, placental weight, embryo weight, and placental efficiency were higher in 4X versus 1X choline. Higher concentrations …

Protection Of Cells From Degeneration And Treatment Of Geographic Atrophy, Jayakrishna Ambati

Ophthalmology and Visual Science Faculty Patents

Therapeutic uses P2X₇ inhibition and inhibition of IRAK1 and/or IRAK4, methods protecting a cell, and screening methods for identifying inhibitors are described herein.

Pixuna Virus Modifies Host Cell Cytoskeleton To Secure Infection, Pedro Ignacio Gil, Guillermo Albrieu-Llinás, Estela Cecilia Mlewski, Marina Monetti, Laura Fozzatti, Cecilia Cuffini, José Fernández-Romero, Patricia Kunda, María Gabriela Paglini

Publications and Research

Pixuna virus (PIXV) is an enzootic member of the Venezuelan Equine Encephalitis Virus complex and belongs to the New World cluster of alphaviruses. Herein we explore the role of the cellular cytoskeleton during PIXV replication. We first identified that PIXV undergoes an eclipse phase consisting of 4 h followed by 20 h of an exponential phase in Vero cells. The infected cells showed morphological changes due to structural modifications in actin microfilaments (MFs) and microtubules (MTs). Cytoskeletonbinding agents, that alter the architecture and dynamics of MFs and MTs, were used to study the role of cytoskeleton on PIXV replication. The …

Apse Employment First Statement, Apse, Green Mountain Self Advocates, Self Advocates Becoming Empowered, Thinkwork! At The Institute For Community Inclusion At Umass Boston

ThinkWork! Publications

These authors worked together to write a statement about what Employment First means and why it’s important. Here is an excerpt from the statement.

All people with disabilities should have opportunities to work. Public dollars should be used to pay for supports for people to work in the community. People with disabilities, their families, and their allies believe that:

• All people should have opportunities for real jobs with real wages. It will get us out of poverty. We will be more independent. We will feel more included. All people, with and without disabilities, can work in jobs together earning minimum …

08-08-2017 Notice Of The Hsc Committee Meeting, Patrice Martin

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Macrophage Type 2 Differentiation In A Patient With Laryngeal Squamous Cell Carcinoma And Metastatic Prostate Adenocarcinoma To The Cervical Lymph Nodes., Michael C. Topf, Madalina Tuluc, Larry A. Harshyne, Adam J. Luginbuhl

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

BACKGROUND: The tumor microenvironment often polarizes infiltrating macrophages towards a type 2, or M2 phenotype, that is characterized by expression of various cysteine-rich, scavenger receptors, including CD163. The primary function of M2 macrophages is to facilitate wound healing. As such, they are capable of providing metabolic support to a growing tumor, neovascularization, as well as protection from cytotoxic T cells. The tumor microenvironment contains a milieu of secreted factors and vesicles, which in certain circumstances can gain access to lymphatic vessels that drain to local lymph nodes.

CASE PRESENTATION: We report a 59-year-old male with recurrent T4 squamous cell carcinoma …

Danshen-Chuanxiong-Honghua Ameliorates Cerebral Impairment And Improves Spatial Cognitive Deficits After Transient Focal Ischemia And Identification Of Active Compounds., Xianhua Zhang, Wan Zheng, Tingrui Wang, Ping Ren, Fushun Wang, Xin-Liang Ma, Jian Wang, Xi Huang

Department of Emergency Medicine Faculty Papers

Previously, we only apply a traditional Chinese medicine (TCM) Danshen-Chuanxiong-Honghua (DCH) for cardioprotection via anti-inflammation in rats of acute myocardial infarction by occluding coronary artery. Presently, we select not only DCH but also its main absorbed compound ferulic acid (FA) for cerebra protection via similar action of mechanism above in animals of the transient middle cerebral artery occlusion (tMCAO). We investigated whether oral administration of DCH and FA could ameliorate MCAO-induced brain lesions in animals. By using liquid chromatography-tandem mass spectrometry (LC-MS/MS), we analyzed four compounds, including tanshinol, salvianolic acid B, hydroxysafflor yellow A and especially FA as the putative …

Weak Relationships Between Three Clinical Assessments And Core Stability Tests, Andy Waldhelm, Li Li

Health Sciences & Kinesiology: Faculty Publications

Core stability measurements are commonly used to identify individuals who may be at risk for athletic injuries. However, the relationship between core stability tests and other clinical assessments used to assess injury risk are not well established. The purpose if this study is to determine the relationships between three clinical assessments and core stability tests. We anticipate the relationships between the three clinical assessments and core stability tests will be low and not significant. Participants included 36 college-aged males and females. The three clinical assessments consisted of the Star Excursion Test and the Frontal Plane Projection Angel (FPPA) of the …

Cellular And Molecular Targets Of Menthol Actions, Murat Oz, Eslam G. El Nebrisi, Keun Hang S. Yang, Frank C. Howarth, Lina T. Al Kury

All Works

© 2017 Oz, El Nebrisi, Yang, Howarth and Al Kury. Menthol belongs to monoterpene class of a structurally diverse group of phytochemicals found in plant-derived essential oils. Menthol is widely used in pharmaceuticals, confectionary, oral hygiene products, pesticides, cosmetics, and as a flavoring agent. In addition, menthol is known to have antioxidant, anti-inflammatory, and analgesic effects. Recently, there has been renewed awareness in comprehending the biological and pharmacological effects of menthol. TRP channels have been demonstrated to mediate the cooling actions of menthol. There has been new evidence demonstrating that menthol can significantly influence the functional characteristics of a number …

Cellular And Molecular Targets Of Menthol Actions, Murat Oz, Eslam El Nebrisi, Keun-Hang Susan Yang, Frank Christopher Howarth, Lina T. Al Kury

Mathematics, Physics, and Computer Science Faculty Articles and Research

Menthol belongs to monoterpene class of a structurally diverse group of phytochemicals found in plant-derived essential oils. Menthol is widely used in pharmaceuticals, confectionary, oral hygiene products, pesticides, cosmetics, and as a flavoring agent. In addition, menthol is known to have antioxidant, anti-inflammatory, and analgesic effects. Recently, there has been renewed awareness in comprehending the biological and pharmacological effects of menthol. TRP channels have been demonstrated to mediate the cooling actions ofmenthol. There has been new evidence demonstrating thatmenthol can significantly influence the functional characteristics of a number of different kinds of ligand and voltage-gated ion channels, indicating that at …

Assessing The Utility Of Phenylene Ethynylenes Against Candida Species Pathogens, Rina Sylejmani

Biomedical Engineering ETDs

Candida species are the cause of many bloodstream infections through contamination of indwelling medical devices. These infections account for a 40% mortality rate, posing a significant risk to immunocompromised patients. Traditional treatments against Candida infections include amphotericin B and various azole treatments. Unfortunately, these treatments are associated with high toxicity, and resistant strains have become more prevalent. As a new frontier, light-activated phenylene ethynylenes have shown promising biocidal activity against Gram-positive and -negative bacterial pathogens, as well as the environmental yeast, Saccharomyces cerevisiae. In this thesis, we monitored the viability of Candida species after treatment with a cationic conjugated …

What's Happening: July 17, 2017, Maine Medical Center

What's Happening

No abstract provided.

Wine Flavor Perception In A Person With Isolated Congenital Aglossia, Naïve Wine Taster, And Sommelier, Kristin Mahood, Long Wang, Betty Mcmicken, Cheryl Rock

Communication Sciences and Disorders Faculty Articles and Research

Objective: This study aimed to augment previous research that investigated flavor perception in isolated congenital aglossia by a whole food/beverage approach. Isolated congenital aglossia is the rare condition of absence of a tongue at birth without the presence of other symptoms. Previous studies confirmed taste perception in isolated congenital aglossia using single taste solutions including sour, salty, sweet, bitter, and umami.

Methods: The current randomized, double-blinded study age- and sex-matched a naïve wine taster and sommelier to the 46 year-old female with isolated congenital aglossia. A Nose and Palate Survey with 54 variables created based on the Court …

The Effect Of Undergraduate Exposure And Experience On Choosing To Pursue A Pharmacy Degree, Erica M. Mcgovern, Ms, Andrew Stacy, Bs, Elena Schmidt, Phd, Ma, Elena Umland, Pharmd

College of Pharmacy Posters

BACKGROUND

• Shortage of pharmacists identified by Department of Health and Human Services in 20001
• Despite investment of significant recruitment resources to achieve optimum enrollment, fewer applications are being submitted for consideration to pharmacy school, and the number of students pursuing pharmacy school continues to decline2
• American Association of Colleges of Pharmacy (AACP) Recruitment Admissions Task Force speculates that qualified candidates may be pursuing other healthcare professions due to lack of awareness of and limited exposure to the expanding role of the pharmacist2
• Limited studies have been conducted to evaluate the primary factors motivating students to pursue a career in pharmacy …

Protocol Adherence For Continuously Titrated Interventions In Randomized Trials: An Overview Of The Current Methodology And Case Study., F Lauzier, N K Adhikari, A Seely, K K Y Koo, E P Belley-Côté, K E A Burns, D J Cook, F D'Aragon, B Rochwerg, M E Kho, S J W Oczkowksi, E H Duan, M O Meade, A G Day, F Lamontagne

Articles, Abstracts, and Reports

BACKGROUND: The standard definition for protocol adherence is the proportion of all scheduled doses that are delivered. In clinical research, this definition has several limitations when evaluating protocol adherence in trials that study interventions requiring continuous titration.

DISCUSSION: Building upon a specific case study, we analyzed a recent trial of a continuously titrated intervention to assess the impact of different definitions of protocol deviations on the interpretation of protocol adherence. The OVATION pilot trial was an open-label randomized controlled trial of higher (75-80 mmHg) versus lower (60-65 mmHg) mean arterial pressure (MAP) targets for vasopressor therapy in shock. In this …

Patients And Nurses And Doctors Oh My!: Nurse Retention From A Multi-Foci Aggression Perspective, Kevin Oliver Novak

Dissertations and Theses

Attrition is a serious issue in the nursing industry. One factor influencing rates of attrition in nursing is aggression victimization at work (Estryn-Behar et al., 2010). However, there is little research in the aggression literature that examines how aggression from different sources affects attrition (both job and career turnover) differently. This study attempts to better understand the linkages between aggression victimization and nursing attrition; specifically how aggression from different sources (i.e. patients/patients’ families, coworkers, and licensed independent practitioners) differentially affects retention factors (i.e. job satisfaction, turnover intentions, and career commitment). This study also attempts to understand the role that prosocial …

Alzheimer's Disease Genetics And Abca7 Splicing, Jared B. Vasquez, James F. Simpson, Ryan Harpole, Steven Estus

Physiology Faculty Publications

Both common and rare polymorphisms within ABCA7 have been associated with Alzheimer’s disease (AD). In particular, the rare AD associated polymorphism rs200538373 was associated with altered ABCA7 exon 41 splicing and an AD risk odds ratio of ∼1.9. To probe the role of this polymorphism in ABCA7 splicing, we used minigene studies and qPCR of human brain RNA. We report aberrant ABCA7 exon 41 splicing in the brain of a carrier of the rs200538373 minor C allele. Moreover, minigene studies show that rs200538373 acts as a robust functional variant in vitro. Lastly, although the ABCA7 isoform with an extended …

“That Pain Is Genuine To Them”: Provider Perspectives On Chronic Pain In University Student Populations, Alexandra C.H. Nowakowski, Kaitlyn E. Barningham, Charlyn D. Buford, Martin Laguerre, J. E. Sumerau

The Qualitative Report

We explored provider attitudes about and experiences in chronic pain management for university student populations. Our central question was: “What do providers at a large university campus health care center experience in the process of offering pain management services?” We explored instrumental, behavioral, emotional, and attitudinal dimensions of our participants’ experiences using a qualitative case study approach. Data were gathered through semi-structured interviews with 10 health care providers at the student health center for a large research university in Florida. Interviews captured providers’ background and experiences in providing pain management to student patients with diverse needs. We used grounded theory …

Perceptions Of Athletes In Disabled And Non-Disabled Sport Contexts: A Descriptive Qualitative Research Study, Sheryl L. Chatfield, Michael Cottingham Ii

The Qualitative Report

The term supercrip suggests extraordinary feats but is sometimes applied to any proficiency demonstrated by an athlete with a disability. This use of the term potentially undermines spectator appreciation for achievements of the upper echelon of disability sports participants. Prior disability sport researchers have suggested that a comparison of individuals’ perceptions of athletic heroes with and without disabilities has potential to help disability sport marketers counter the supercrip stereotype. The purpose of this research was to explore differences in perceptions by comparing participant descriptions of role models with and without disabilities. Research participants, who consisted of undergraduate students at a …

Design And Implementation Of An Elective Career Planning Course For Pharmacy Students, Jennifer K. Grundey, Kelly Shields

Pharmacy Faculty Scholarship

Objective: The Accreditation Council for Pharmacy Education Standards 2016 encourage student pharmacists to examine and reflect on attributes necessary for professional and personal growth. Data from an AACP survey of recent graduates also indicated perceived deficiencies in career planning. Therefore, an elective course was created for 5^th year students (0-6 program) to encourage self-assessment and preparation for post-graduate employment and personal development. The objective of this poster is to describe important elements of this course to aid faculty at other intuitions.

Method: The course was designed after review of publications regarding career advancement and life-skills. Additionally, business …

Medical School Watercooler Newsletter - July 16, 2017, Lindsey Lyle

Watercooler Newsletter

This is the July 16, 2017 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

USA Medical Student Lauren Nelson Attends American Academy of Pediatrics Meeting

Pediatrics Hosting Grand Rounds July 21

USA Welcomes Dr. Meir Mizrahi

Alterations In Gene Expression Of Components Of The Renin-Angiotensin System And Its Related Enzymes In Lung Cancer., Benjamin Goldstein, Malav Suchin Trivedi, Robert Charles Speth

Faculty Articles

Objectives. The study assessed the existence and significance of associations between the expression of fifteen renin-angiotensin system component genes and lung adenocarcinoma. Materials and Methods. NCBI’s built-in statistical tool, GEO2R, was used to calculate Student’s -tests for the associations found in a DNA expression study of adenocarcinoma and matched healthy lung tissue samples. The raw data was processed with GeneSpring™ and then used to generate figures with and without Sidak’s multiple comparison correction. Results. Ten genes were found to be significantly associated with adenocarcinoma. Seven of these associations remained statistically significant after correction for multiple comparisons. Notably, AGTR2, which encodes …

Challenges And Solutions In Library And Information Sciences: Formulating A Pharmacy Collection Without A Prescription, Kristin Laughtin-Dunker

Library Presentations, Posters, and Audiovisual Materials

Librarians, pharmacists, and scientists encounter diverse challenges relating to knowledge management, the creation, organization, and retrieval of information. This session will highlight current challenges faced in this area by colleagues from across the Academy. Participants will have the opportunity to engage in two roundtable discussions. By the end of the session, participants will be able to describe current challenges faced in Library and Information Science, and bring solutions back to their academic program.

These slides include the "Formulating a Pharmacy Collection Without a Prescription" portion of the panel, which discussed the collection development process for a group of non-health science …

Estimating The Impact Of Assessment And Treatment Fidelity On Aphasia Treatment Outcomes, Trisha L. Tanaka

Speech and Hearing Sciences ETDs

Purpose: Calls for treatment and assessment fidelity strongly suggest the need to reduce treatment provider and assessor variance surrounding intervention research. The extent to which these sources of variance influence treatment outcomes in aphasia treatment research has yet to be examined. This simulation study sought to explore the relationships between quality of fidelity methods, sample size, power to detect treatment effects, and aphasia treatment effect sizes.

Methods: Individual participant outcomes collected from previous aphasia treatment research studies were used to simulate 200,000 participant outcomes, from which 8,000 sample treatment trials were simulated. Effect sizes were calculated for treatment outcomes related …

Mdm2 Is Required For Survival And Growth Of P53-Deficient Cancer Cells., Kyle P Feeley, Clare M. Adams, Ramkrishna Mitra, Christine M. Eischen

Department of Cancer Biology Faculty Papers

p53 deletion prevents the embryonic lethality of normal tissues lacking Mdm2, suggesting that cells can survive without Mdm2 if p53 is also absent. Here we report evidence challenging this view, with implications for therapeutically targeting Mdm2. Deletion of Mdm2 in T-cell lymphomas or sarcomas lacking p53 induced apoptosis and G₂ cell-cycle arrest, prolonging survival of mice with these tumors. p53^-/- fibroblasts showed similar results, indicating that the effects of Mdm2 loss extend to pre-malignant cells. Mdm2 deletion in p53^-/- cells upregulated p53 transcriptional target genes that induce apoptosis and cell-cycle arrest. Mdm2 deletion also increased levels of …

Data For High-Throughput Estimation Of Specific Activities Of Enzyme/Mutants In Cell Lysates Through Immunoturbidimetric Assay Of Proteins, Yiran Feng, Xiaolan Yang, Huimin Chong, Deqiang Wang, Xiaolei Hu, Chang-Guo Zhan, Fei Liao

Molecular Modeling and Biopharmaceutical Center Faculty Publications

Data in this article are associated with the research article “Highthroughput estimation of specific activities of enzyme/mutants in cell lysates through immunoturbidimetric assay of proteins” (Yang et al., 2017) [1]. This article provided data on how to develop an immunoturbidimetric assay (ITA) of enzyme/mutants as proteins in cell lysates in high-throughput (HTP) mode together with HTP assay of their activities to derive their specific activities in cell lysates for comparison, with Pseudomonas aeruginosa arylsulfatase (PAAS) and Bacillus fastidious uricase (BFU) plus their mutants as models. Data were made publicly available for further analyses.