Medicine and Health Sciences Commons^™

Advertising Exposure And Use Of E-Cigarettes Among Female Current And Former Tobacco Users Of Childbearing Age, Kristin Ashford, Emily Rayens, Amanda T. Wiggins, Mary Kay Rayens, Amanda Fallin-Bennett, Molly Malany Sayre

Nursing Faculty Publications

Objective: The study examined the relationship between exposure to e‐cigarette advertising and e‐cigarette use by pregnancy status, including use of flavored e‐cigarette products, among women of childbearing age.

Design: A cross‐sectional, correlational design was used.

Subjects: Female current or former tobacco users in Central and Eastern Kentucky, 18–45 years old (N = 194, 52% pregnant).

Measures: Demographics, pregnancy status, cigarette and e‐cigarette use, and exposure to e‐cigarette advertising.

Results: Younger age, white non‐Hispanic race, and greater exposure to e‐cigarette advertising were associated with a higher likelihood of ever using e‐cigarettes (p < .05 for each variable). Pregnancy was not associated with ever use (p = .11). Younger age was associated …

Carotid Intima Media Thickness Percentiles For Pakistani Population, Waseem Mirza, Mubashir Aslam Arain, Arif Ali, Vaqar Bari, Mirza Kazim Ali, Kainat Fatima

Department of Radiology

Carotid artery intima media thickness estimation is a well-established way of cardio vascular disease evaluation. The purpose of this cross-sectional study was to develop normal carotid intima media thickness percentile values for a Pakistani cohort. Data was collected at the Departments of Radiology and Family Medicine, The Aga Khan University Hospital, Karachi, from April 2014 to August 2015. High frequency ultrasound of carotid was done in 257 patients [97 male (38%), 160 female (62%)] without any known carotid artery disease. Reference ranges (90% range between 5th and 95th centiles) were constructed for each common carotid and internal carotid artery measurement …

Comparison Of Home Fortification With Two Iron Formulations Among Kenyan Children: Rationale And Design Of A Placebo-Controlled Non-Inferiority Trial, Emily M. Teshome, Walter Otieno, Sofie R. Terwel, Victor Osoti, Ayşe Y. Demir, Pauline E.A. Andango, Andrew M. Prentice, Hans Verhoef

All Peer-Reviewed Publications

Introduction Home fortification powders containing iron and other micronutrients have been recommended by World Health Organisation to prevent iron deficiency anaemia in areas of high prevalence. There is evidence, however, that home fortification at this iron dose may cause gastrointestinal adverse events including diarrhoea. Providing a low dose of highly absorbable iron (3 mg iron as NaFeEDTA) may be safer because the decreased amount of iron in the gut lumen can possibly reduce the burden of these adverse effects whilst resulting in similar or higher amounts of absorbed iron. Objective To show non-inferiority of home fortification with 3 mg iron …

2484: Establishment Of The Tennessee-Sickle Cell Disease Network As A Mechanism For Engaging A Rare Disease Population In Patient Centered Outcomes Research, Tilicia Mayo-Gamble, Velma Mcbride Murry, Michael R. Debaun

Health Policy & Community Health: Faculty Publications

OBJECTIVES/SPECIFIC AIMS: Despite the high prevalence of individuals diagnosed with sickle cell disease (SCD) in Tennessee, comprehensive care and education for patients with SCD is not as widely available as healthcare services for individuals managing other chronic illnesses. We aimed to engage SCD stakeholders in patient-centered outcomes research (PCOR) as a mechanism for advancing care and translational research for this rare disease population. METHODS/STUDY POPULATION: Through a partnership with the Sickle Cell Foundation of Tennessee, we implemented Community Health Ambassadors to systematically engage patient partners with SCD and their caregivers, aged 18–50 from rural and urban communities throughout Tennessee, in …

Effects Of Wire Material, Deflection, And Interbracket Distance On Burstone Bracket Geometry Force Systems, Skyler J. Liatti

Loma Linda University Electronic Theses, Dissertations & Projects

Objective. This paper aims to quantify the effect of wire material, dimension, and deflection on the most identifiable feature of the six-geometries: the moment dissociation point (force system with no moment on the lesser angled bracket), which may or may not occur at the classically defined geometry IV. Materials and Methods. A six-degree of freedom load cell was used to measure the force systems in different combinations of wire materials, wire dimensions, total angle of bracket, and interbracket distance. Brackets were progressively rotated through Burstone and Koenig’s six geometries and the moment on the right bracket was plotted against the …

Genomic Selection And Its Application In Animal Breeding, Fahar Ibtisham, Li Zhang, Mei Xiao, Lilong An, Muhammad Bilal Ramzan, Aamir Nawab, Yi Zhao, Guanghui Li, Yingmei Xu

The Thai Journal of Veterinary Medicine

A significant gap exists between animal production and world’s population demand. Although conventional breeding methods have been effectual for selection of animal populations on many traits of economic importance, with these methods, the accuracy of breeding value always remains questionable. Simulation and experimental results suggest that breeding values can be predicted with high accuracy by genomic selection for young animals without own performance. Genomic selection is a type of marker-assisted selection in which genetic markers covering the whole genome are used so that all quantitative trait loci are in linkage disequilibrium with at least one marker. The possibility to select …

Post-Natal Development Of Some Lymphoid Organs Of West African Dwarf (Wad) Goats: A Histological Perspective, Anietie Francis Udoumoh, Clifford Nwabugwu Abiaezute

The Thai Journal of Veterinary Medicine

The study evaluated the developmental changes in the mesenteric lymph nodes, thymus and spleen of West African Dwarf (WAD) goat using histological techniques. Twenty-seven WAD goats of 1 day, 2 weeks and 1 to 7 months old were used for this study. Results showed that the mesenteric lymph node of the WAD goats had poorly organized cortical and medullary areas at 1 day postnatum, and dense infiltration of lymphocytes in the cortex with a few primary lymphoid follicles at 2 and 3 months. At 1 day old, the thymus exhibited thin cortical parenchyma and extensive medullary areas. The thymic parenchyma …

Identification And Antimicrobial Susceptibility Of Lactic Acid Bacteria From Fecal Samples Of Indigenous And Commercial Pigs, Wandee Sirichokchatchawan, Somboon Tanasupawat, Waree Niyomtham, Nuvee Prapasarakul

The Thai Journal of Veterinary Medicine

Lactic acid bacteria (LAB) are currently applied as probiotics due to their benefit to pig performance. This study aimed to identify candidate LAB from pig feces and determine their antimicrobial susceptibility following an international standard recommendation. A total of 204 LAB isolates from 60 fecal samples of 30 antibiotic-free healthy fattening indigenous pigs and 30 antibiotic-free healthy fattening commercial pigs were initially screened for viability in acidic and bile conditions. Thirty-four of the isolates as acid- and bile-tolerant LAB were selected for identification and determination of antimicrobial susceptibility. They were characterized and identified by a set of 26 phenotypic tests, …

Seropositivity Of Brucellosis In Human And Livestock In Tribal-Kurram Agency Of Pakistan Indicates Cross Circulation, Abdul Qadir Khan, Syed Kashif Haleem, Muhammad Shafiq, Nazir Ahmad Khan, Sadeeq Ur Rahman

The Thai Journal of Veterinary Medicine

Brucellosis is an endemic disease in Pakistan, yet an overall systemic surveillance data of the country is missing. This study aims to determine seroprevalence in domestic livestock population and high and low risk-associated humans of tribal Kurram Agency, Pakistan. A total of 567 random animal blood samples (148 cattle, 105 buffaloes, 154 sheep, and 160 goats), 197 human serum samples (n= 83 from low risk population n= 114 from high risk individuals) and ,in order to establish association between abortion and brucellosis, additional 395 animals with maximum of 4 weeks of foetal-birth history with or without abortion were initially screened …

A Rabbit Model For Evaluating The Efficacy Of Recombinant Adenovirus Vaccine Expressing E0-E2 Antigens Of Classical Swine Fever Virus, Heng Zhang, Yong-Ke Sun, Xiao-Miao Zhang, Hui Zhang, Gen-Cheng Fan, Yu-Lin Yan, Yu-Ai Yang

The Thai Journal of Veterinary Medicine

This study investigated the efficacy of a recombinant adenovirus vaccine expressing E0-E2 antigens (rAd-E0-E2) of the classical swine fever virus (CSFV) and determined its minimum effective dose in rabbits. Forty rabbits were randomly divided into five groups. Three groups were immunized intramuscularly with rAd-E0-E2 at doses of 107.0, 106.0 and 105.0 IFU, respectively. CSFV C strain was administered to one group and saline to another group (negative control). Fourteen days after immunization, the animals were challenged intramuscularly with CSFV C strain. Stereotypical thermal responses were monitored to assess the protective efficacy of the vaccine. No typical thermal response was observed …

Diagnostic Value Of Echocardiographic Indices And Cardiac Biomarkers In Dogs With Chronic Mitral Valve Insufficiency, Hyun-Seok Kim, Sang-Il Suh, Changbaig Hyun

The Thai Journal of Veterinary Medicine

Because all dogs having heart diseases are not in symptomatic heart failure stage, it is important to determine the stage of heart failure in dogs with heart diseases. Therefore, this study evaluated the diagnostic value of several echocardiographic parameters and cardiac biomarkers for differentiating dogs with heart disease from healthy dogs and dogs with symptomatic heart failure from dogs with asymptomatic heart failure. The study population consisted of 51 dogs having chronic mitral valvular insufficiency (CMVI) with varying degrees of heart failure and 18 healthy control dogs. Several echocardiographic parameters and cardiac biomarkers were evaluated to achieve the study aims. …

Prevalence And Pathology Of Bovine Coccidiosis In Faisalabad District, Pakista, Riaz Hussain, Fazal Mahmood, Ahrar Khan, Khalid Mehmood

The Thai Journal of Veterinary Medicine

The study aimed to investigate the presence of coccidial oocysts and pathological changes in a dairy herd with the history of coccidial outbreak in Faisalabad District. Fecal samples were collected from 541 animals, including cattle (379) and buffaloes (162), and examined for protozoal infection using flotation techniques. Results revealed 2.9% presence of coccidial oocysts in the samples collected. No significant difference was found in coccidial oocysts count in species of the cattle (2.3%) and buffaloes (4.3%), sex and age group. Necropsy revealed no gross lesions in thoracic organs, however, severe hemorrhages and necrotic ulcers were present in the cecum and …

Ecg Quiz, Chollada Buranakarl, Saikaew Sutayatram

The Thai Journal of Veterinary Medicine

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Covering The Cover, Wei Wu, Jingdi Chen, Qianshan Ding, Dongmei Yang, Honggang Yu, Jun Lin

Department of Medicine

Background/Aims: Endoscopic submucosal dissection has been widely accepted. At present, the number of antiplatelet (APT) users has been growing. Moreover, because of high risks of thromboembolism, some patients need to continuously receive APT agents. The relationship between hemorrhage and continuous therapy with low-dose aspirin (LDA) remains controversial.

Materials and Methods: A systematic search was conducted; studies were screened out- if data of no-anticoagulant/APT drugs use and interrupted and continued-LDA use were reported separately. The Newcastle-scale was chosen to assess the quality of the included studies. Review Manager 5.2 was used for quality assessment statistical analysis, and the odd ratio (OR) …

September 2017, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

No abstract provided.

Results From Application To An Absorbable Synthetic Membrane To Superficial And Deep Second Degree Wounds., Sigrid A. Blome-Eberwein Md, Patrick Pagella Msn, Arnp, Bsn, Rn, Deborah Boorse Rn, Cnp, Hamed Amani Md

Department of Surgery

No abstract provided.

A “Standardized Patient” To Validate The Competency Of Sanes, Amanda Howatt Bsn, Rn, Cen, Devin Kennedy Msn, Rn, Cen, Sandra Sabbatini Msn, Rn-Bc, Cen, Michele Rice Bsn, Rn, Cen

Patient Care Services / Nursing

No abstract provided.

Evaluation Of Die Trim Morphology Made By Cad-Cam Technology, Pratiksha Agrawal, Geoffrey A. Thompson, Seok-Hwan Cho, Gerald J. Ziebert

School of Dentistry Faculty Research and Publications

Statement of problem

The die contour can affect the emergence profile of prosthetic restorations. However, little information is available regarding the congruency between a stereolithographic (SLA) die and its corresponding natural tooth.

Purpose

The purpose of this vitro study was to evaluate the shapes of SLA die in comparison with the subgingival contour of a prepared tooth to be restored with a ceramic crown.

Material and methods

Twenty extracted human teeth, 10 incisors, and 10 molars, were disinfected and mounted in a typodont model. The teeth were prepared for a ceramic restoration. Definitive impressions were made using an intraoral scanner …

S-100 Negative Granular Cell Tumor (So-Called Primitive Polypoid Non-Neural Granular Cell Tumor) Of The Oral Cavity, Yeshwant B. Rawal, Thomas B. Dodson

School of Dentistry Faculty Research and Publications

Four cases of cutaneous S-100 negative granular cell tumor were described in 1991. Until now, only 3 cases of oral involvement have been documented in English literature. Two additional cases of oral S-100 negative granular cell tumor are described. Immunohistochemical markers were applied to exclude other lesions that may show the presence of granular cells. The clinical findings were correlated with the histopathological and immunohistochemical features to arrive at the appropriate diagnosis. S-100 negative granular cell tumors are erythematous polypoid masses commonly mistaken for granulation tissue or a pyogenic granuloma. Any part of the oral cavity may be affected. Histopathologically, …

Strain Specific Effects Of Low Level Lead Exposure On Associative Learning And Memory In Rats., Megha Verma, J. S. Schneider

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Exposure to lead (Pb) remains a significant public health concern. Lead exposure in early life impairs the normal development of numerous cognitive and neurobehavioral processes. Previous work has shown that the effects of developmental Pb exposure on gene expression patterns in the brain are modulated by various factors including the developmental timing of the exposure, level of exposure, sex, and genetic background. Using gene microarray profiling, we previously reported a significant strain-specific effect of Pb exposure on the hippocampal transcriptome, with the greatest number of differentially expressed transcripts in Long Evans (LE) rats and the fewest in Sprague Dawley (SD) …

Subcutaneous Implantation Of The Light-Activated Pit And Fissure Resin-Based Sealant Prototypes Las-Clear And Las-Opaque Resulted In A Mild Transient Tissue Reaction, Pasutha Thunyakitpisal, Nonglax Thunyakitpisal, Dyna Jeanne D. Godoy, Onusa Saravari, Dujreutai Pongkao Kashima, Benchaphorn Limcharoen, Wijit Banlunara

The Thai Journal of Veterinary Medicine

The objective of this study was to evaluate the biocompatibility of the light-activated pit and fissure resin-based dental sealant prototypes, LAS-clear and LAS-opaque, after subcutaneous implantation in rats for 7, 30, and 60 days. The commercial light-activated resin-based sealants, Delton-clear (DC), Helioseal clear (HC), Helioseal opaque (HO), and Clinpro Sealant (CL) served as control. Twenty-four 8-week-old male Sprague-Dawley rats were used in this study. Two rows of three 5 mm subcutaneous incisions were created on the back of each rat parallel to the midline. The materials were randomly implanted and the incisions were closed using sutures. The implants were left …

Oxidative Stress Biomarkers And Cardiac Troponin I In Arabian Horses With Strangles, Wael M. El-Deeb, Ahmed M. Elmoslemany

The Thai Journal of Veterinary Medicine

In order to investigate the levels of oxidative stress (OS) biomarkers and cardiac troponin I (cTnI) in horses with strangles, fifty horses with strangles and twenty healthy controls were included in this study. Blood and serum samples were tested for levels of cardiac troponin I (cTnI), malondialdehyde (MDA), super oxide dismutase (SOD), glutathione (GSH), nitric oxide (NO) and total antioxidant capacity (TAC). The levels of cTnI were increased in ten diseased cases while normal cTnI levels were found in the others (n=40). The levels of MDA were increased in the horses with strangles when compared with the healthy ones. The …

Ophthalmology Snapshot, Nalinee Tuntivanich

The Thai Journal of Veterinary Medicine

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What Is Your Diagnosis?, Nan Choisunirachon, Chutimon Thanaboonnipat

The Thai Journal of Veterinary Medicine

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Polygenic Hazard Scores In Preclinical Alzheimer's Disease, Chin Hong Tan, Bradley T. Hyman, Jacinth J. X. Tan, Christopher P. Hess, William P. Dillon, Gerard D. Schellenberg, Lilah M. Besser, Walter A. Kukull, Karolina Kauppi, Linda K. Mcevoy, Ole A. Andreassen, Anders M. Dale, Chun Chieh Fan, Rahul S. Desikan

Research Collection School of Social Sciences

Identifying asymptomatic older individuals at elevated risk for developing Alzheimer's disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive decline, even after controlling for APOE e4 carrier status. Older individuals in the highest PHS percentiles showed the highest AD incidence rates. PHS predicted longitudinal clinical decline among older individuals with moderate to high CERAD (amyloid) and Braak (tau) scores at autopsy, even among APOE e4 non-carriers. Beyond APOE, PHS may help identify asymptomatic individuals at highest risk for developing Alzheimer's neurodegeneration.

Mp24- 19- Cost Savings Achieved Through Introduction Of Holep And Care Pathway., James Johannes Md, Andrew Lai, Angelo A. Baccala Md, Joseph Feliciano Md, Clifford Georges Md, Melvin Steinbook Md, Maria Voznesensky Md

Department of Medicine

No abstract provided.

Celiprolol: A Unique Selective Adrenoceptor Modulator, James Nawarskas, Angela Cheng-Lai, William H. Frishman

NYMC Faculty Publications

Celiprolol is a β-blocker with a unique pharmacologic profile: it is a β1-andrenoceptor antagonist with partial β2 agonist activity. Given this combination of effects, celiprolol may be better described as a selective adrenoreceptor modulator. It has antihypertensive and antianginal properties and is indicated for those uses in various countries around the world. In the United States, however, the proposed indication for this drug will be for the treatment of vascular type Ehlers-Danlos syndrome, a rare connective tissue disorder characterized by fragile arterial structure and an increased risk of life-threatening vascular complications. By reducing heart rate and pulsatile pressure, celiprolol may …

Incidence, Risks, And Types Of Infections In Pediatric Long-Term Care Facilities, Lisa Saiman, Philip Maykowski, Meghan Murray, Bevin Cohen, Natalie Neu, Gordon R. Hutcheon, Elaine Larson

NYMC Faculty Publications

Importance: The population of infants, children, and adolescents cared for at pediatric long-term care facilities is increasing in complexity and size and thus consumes substantial health care resources. Infections are a significant cause of morbidity and mortality in this population, but few recent data describe their incidence and effects.

Objectives: To describe the types of infections diagnosed in residents of pediatric long-term care facilities, calculate infection rates, and identify risk factors for respiratory tract infections (RTIs).

Design, Setting, and Participants: This prospective cohort study, which was part of a larger trial called Keep It Clean for Kids, was conducted from …

Borrelia Infection And Risk Of Celiac Disease, A Alaedini, B Lebwohl, Gary P. Wormser, P Green, J Ludvigsson

NYMC Faculty Publications

BACKGROUND: Environmental factors, including infectious agents, are speculated to play a role in the rising prevalence and the geographic distribution of celiac disease, an autoimmune disorder. In the USA and Sweden where the regional variation in the frequency of celiac disease has been studied, a similarity with the geographic distribution of Lyme disease, an emerging multisystemic infection caused by Borrelia burgdorferi spirochetes, has been found, thus raising the possibility of a link. We aimed to determine if infection with Borrelia contributes to an increased risk of celiac disease. METHODS: Biopsy reports from all of Sweden's pathology departments were used to …

Amlexanox Enhances Premature Termination Codon Read-Through In Col7a1 And Expression Of Full Length Type Vii Collagen: Potential Therapy For Recessive Dystrophic Epidermolysis Bullosa., Velina S. Atanasova, Qiujie Jiang, Marco Prisco, Christina Gruber, Josefina Piñón Hofbauer, Mei Chen, Cristina Has, Leena Bruckner-Tuderman, John A. Mcgrath, Jouni Uitto, Andrew P. South

Department of Dermatology and Cutaneous Biology Faculty Papers

Recessive dystrophic epidermolysis bullosa (RDEB) is a rare monogenic blistering disorder caused by the lack of functional type VII collagen, leading to skin fragility and subsequent trauma-induced separation of the epidermis from the underlying dermis. A total of 46% of patients with RDEB harbor at least one premature termination codon (PTC) mutation in COL7A1, and previous studies have shown that aminoglycosides are able to overcome RDEB PTC mutations by inducing "read-through" and incorporation of an amino acid at the PTC site. However, aminoglycoside toxicity will likely prevent widespread clinical application. Here the FDA-approved drug amlexanox was tested for its ability …