Medicine and Health Sciences Commons^™

The Normal Ranges Of Cardiovascular Parameters Measured Using The Ultrasonic Cardiac Output Monitor, Giles N. Cattermole, P.Y Mia Leung, Grace Y.L Ho, Peach W.S Lau, Cangel P.Y Chan, Stewart S.W Chan, Brendan E. Smith, Colin A. Graham, Timothy H. Rainer

Medical Papers and Journal Articles

The ultrasonic cardiac output monitor (USCOM) is a noninvasive transcutaneous continuous wave Doppler method for assessing hemodynamics. There are no published reference ranges for normal values in adults (aged 18– 60 years) for this device. This study aimed to (1) measure cardiovascular indices using USCOM in healthy adults aged 18–60 years; (2) combine these data with those for healthy children (aged 0–12), adolescents (aged 12–18), and the elderly (aged over 60) from our previously published studies in order to present normal ranges for all ages, and (3) establish normal ranges of USCOM-derived variables according to both weight and age. This …

Be Well: A Systems-Based Wellness Intervention Using Mindfulness In The Workplace – A Case Study, Kate M. Levett, Sharyn Coughlan, Sharon Longridge, Violet Roumeliotis, Jon Adams

Medical Papers and Journal Articles

Introduction: Healthy work environments are essential in determining improved well-being of Australians. Job stress has been identified as a significant factor in psychological distress. This study evaluated the effect of introducing a systems-based workplace wellness programme using mindfulness in the workplace.

Methods: The programme ‘Be Well’ was introduced as part of a systems-based approach to workplace health promotion, and evaluated using sick leave as a proxy for workplace stress, and the stress satisfaction offset score to determine the degree of change in stress and satisfaction.

Results: There was significant reduction in sick leave (2014 vs. 2012) (p<.001), and significant improvement in stress satisfaction offset score (p<.05). Logistic regression analysis identified the programme components most predictive of reduced stress and higher job satisfaction.

Conclusion: The impacts …

Isolated Intractable Nausea And Vomiting With Hiccups Heralds A Neuromyelitis Optica Area Postrema Syndrome, Michal Lubomski, Jacqueline Lubomski, Irene Tan, Michael Hayes

Medical Papers and Journal Articles

No abstract is available for this article.

Beneficial Effects On Pregnancy Outcomes Of Thyroid Hormone Replacement For Subclinical Hypothyroidism, N. Blumenthal, C. Eastman

Medical Papers and Journal Articles

Hypothyroidismand raised thyroid antibody levels have been associated with adverse obstetrical outcomes. Several studies have investigated causal associations, but results have been inconsistent and fewstudies have reported the effects of thyroxine replacement therapy on pregnancy outcomes in hypothyroid patients. Objective.The primary study objective was to determine the outcome of pregnancies in women diagnosed with overt and subclinical hypothyroidism (SCH) (serum TSH > 2.5mIU/L) and those with elevated circulating thyroid autoantibody levels in the first trimester of pregnancy and after the institution of appropriate thyroxine replacement therapy to maintain the serum TSH ≤ 2.5mIU/L. Study Design. This prospective observational study was undertaken …

Knowledge Mobilisation For Policy Development: Implementing Systems Approaches Through Participatory Dynamic Simulation Modelling, Louise Freebairn, Lucie Rychetnik, Jo-An Atkinson, Paul Kelly, Geoff Mcdonnell, Nick Roberts, Christine Whittall, Sally Redman

Medical Papers and Journal Articles

Background: Evidence-based decision-making is an important foundation for health policy and service planning decisions, yet there remain challenges in ensuring that the many forms of available evidence are considered when decisions are being made. Mobilising knowledge for policy and practice is an emergent process, and one that is highly relational, often messy and profoundly context dependent. Systems approaches, such as dynamic simulation modelling can be used to examine both complex health issues and the context in which they are embedded, and to develop decision support tools.

Objective: This paper reports on the novel use of participatory simulation modelling as a …

Perceptions Of Recent Medical Graduates And Their Workplace Supervisors Towards A Medical School Clinical Audit Program, Stephanie Davis, Ilse O'Ferrall, Samuel Hoare, Caroline Bulsara, Donna B. Mak

Medical Papers and Journal Articles

Objectives: This study explores how medical graduates and their workplace supervisors perceive the value of a structured clinical audit program (CAP) undertaken during medical school.

Methods: Medical students at the University of Notre Dame Fremantle complete a structured clinical audit program in their final year of medical school. Semi-structured inter-views were conducted with 12 Notre Dame graduates (who had all completed the CAP), and seven workplace supervisors (quality and safety staff and clinical supervisors). Purposeful sampling was used to recruit participants and data were analysed using thematic analysis.

Results: Both graduates and workplace supervisors perceived the CAP to be valuable. …

Evidence For A Comprehensive Approach To Aboriginal Tobacco Control To Maintain The Decline In Smoking: An Overview Of Reviews Among Indigenous Peoples, Catherine Chamberlain, Susan Perlan, Sue Brennan, Lucie Rychetnik, David Thomas, Raglan Maddox, Noore Alam, Emily Banks, Andrew Wilson, Sandra Eades

Medical Papers and Journal Articles

Background: Tobacco smoking is a leading cause of disease and premature mortality among Aboriginal and Torres Strait Islander (Indigenous) Australians. While the daily smoking prevalence among Indigenous Australians has declined significantly from 49% in 2001, it remains about three times higher than that of non-Indigenous Australians (39 and 14%, respectively, for age ≥15 years in 2014–15). This overview of systematic reviews aimed to synthesise evidence about reducing tobacco consumption among Indigenous peoples using a comprehensive framework for Indigenous tobacco control in Australia comprised of the National Tobacco Strategy (NTS) and National Aboriginal and Torres Strait Islander Health Plan (NATSIHP) principles …

Can Peer Education Improve Beliefs, Knowledge, Motivation And Intention To Engage In Falls Prevention Amongst Community-Dwelling Older Adults?, Linda Khong, Richard G. Berlach, Keith D. Hill, Anne-Marie Hill

IHR Papers and Journal Articles

The aim of the study was to evaluate the effectiveness of delivering a contemporary peer-led falls prevention education presentation on community-dwelling older adults’ beliefs, knowledge, motivation and intention to engage in falls prevention strategies. A two-group quasi-experimental pre-test–post-test study using a convenience sample was conducted. A new falls prevention training package for peer educators was developed, drawing on contemporary adult learning and behaviour change principles. A 1-h presentation was delivered to community-dwelling older adults by peer educators trained with the new package (intervention group). Control group participants received an existing, 1-h falls prevention presentation by trained peer educators who had …

Effectiveness Of Peers In Delivering Programs Or Motivating Older People To Increase Their Participation In Physical Activity: Systematic Review And Meta-Analysis, Elissa Burton, Kaela Farrier, Keith Hill, James Codde, Phil Airey, Anne-Marie Hill

Health Sciences Papers and Journal Articles

The objective of this systematic review and meta-analysis was to evaluate the effectiveness of peers to deliver programs or encourage older people to be physically active and improve physical outcomes. Peer reviewed articles published in English between January 1976 and June 2016, retrieved from six databases according to the predefined inclusion criteria were included. Where possible results were pooled and meta-analyses conducted. Eighteen articles were included in the review, a total of 3,492 intervention participants, average age 66.5 years and 67.1% were female. Overall, study quality was medium to high. Interventions mainly included resistance, flexibility and cardiovascular training, however there …

Physical Determinants Of Division 1 Collegiate Basketball, Women’S National Basketball League And Women’S National Basketball Association Athletes: With Reference To Lower Body Sidedness, T Spiteri, M Binetti, A Scanlan, V Dalbo, F Dolci, C Specos

Health Sciences Papers and Journal Articles

In female basketball the assumed components of success include power, agility, and the proficiency at executing movements using each limb. However, the importance of these attributes in discriminating between playing levels in female basketball have yet to be determined. The purpose of this study was to compare lower body power, change of direction (COD) speed, agility, and lower-body sidedness between basketball athletes participating in Division 1 Collegiate basketball (United States), Women's National Basketball League (WNBL) (Australia), and Women's National Basketball Association (WNBA) (United States). Fifteen female athletes from each league (N = 45) completed a double and single leg counter-movement …

Patient Evaluation Of Emotional Comfort Experienced (Peece): Developing And Testing A Measurement Instrument, A Williams, L Lester, C Bulsara, A Petterson, K Bennett, E Allen, D Joske

Health Sciences Papers and Journal Articles

Objectives: The Patient Evaluation of Emotional Comfort Experienced (PEECE) is a 12-item questionnaire which measures the mental well-being state of emotional comfort in patients. The instrument was developed using previous qualitative work and published literature.

Design: Instrument development.

Setting: Acute Care Public Hospital, Western Australia.

Participants: Sample of 374 patients.

Interventions: A multidisciplinary expert panel assessed the face and content validity of the instrument and following a pilot study, the psychometric properties of the instrument were explored.

Main outcome measures: Exploratory and confirmatory factor analysis assessed the underlying dimensions of the PEECE instrument; Cronbach’s α was used to determine the …

Community-Based Prescribing For Impetigo In Remote Australia: An Opportunity For Antimicrobial Stewardship, S Oliver, J Cush, J Ward

Health Sciences Papers and Journal Articles

Background: To support antibiotic prescribing for both hospital and community-based health professionals working in remote North Western Australia, a multidisciplinary Antimicrobial Stewardship (AMS) Committee was established in 2013. This Committee is usually focused on hospital-based prescribing. A troubling increase in sulfamethoxazole/ trimethoprim resistance in Staphylococcus aureus antibiograms from 9 to 18% over 1 year prompted a shift in gaze to community prescribing.

What we did: Finding a paucity of relevant research, we first investigated contextual factors influencing local prescribing. We also designed a systematic survey of experts with experience relevant to our setting using a structured response survey (12 questions) …

Lack Of Evidence For Decreased Protein Stability In The 2397 (Met) Haplotype Of The Leucine Rich Repeat Kinase 2 Protein Implicated In Parkinson’S Disease, Ryan S. Anderton, Lauren Hill, Rhiannon Morris, Frank L. Mastaglia, Wayne Greene, Sherif Boulos

Health Sciences Papers and Journal Articles

Missense mutations in the leucine rich repeat kinase 2 (LRRK2) gene are the leading genetic cause of autosomal dominant familial Parkinson’s disease. We previously reported that two mutations within the ROC domain, namely R1441C and A1442P, exhibit increased protein degradation leading to lowered steady state LRRK2 protein levels in HEK293 cells. More recently, the common WD40 domain LRRK2 haplotype, Met2397, which is a risk factor for Crohn’s disease, has been shown to lower steady state protein levels in HEK293 cells. In view of recent evidence implicating LRRK2 and inflame-mation in PD, we investigated the effects of Met2397 on LRRK2 expression, …

Changes In Fatty Acid Composition Of Human Milk In Response To Cold-Like Symptoms In The Lactating Mother And Infant, Andrew S. Gardner, Ibrahim A. Rahman, Ching T. Lai, Anna Hepworth, Naomi Trengove, Peter E. Hartmann, Donna T. Geddes

Health Sciences Papers and Journal Articles

Infants rely on their innate immune systems to protect them from infection. Human milk (HM) contains fatty acids (FAs) and monoacylglycerols that are known to exhibit antiviral and antibacterial properties in vitro. The specific fat content of HM may potentially affect the efficacy of this antimicrobial activity. This preliminary study investigates whether the proportions of FA in HM change in response to infections, leading to cold-like symptoms in the mother or infant. Milk samples were obtained from mothers (n = 26) when they and their infants were healthy, and when mother, infant, or both suffered cold-like symptoms. The milk was …

Eeg Neurofeedback For Executive Functions In Children With Neurodevelopmental Challenges, Jasmin K. Landes, Corinne L. Reid, Martijn Arns, Nicholas A. Badcock, Tomas Ros, Stefanie Enriquez-Geppert, Max K. Bulsara, Stefano Brini, Sheida Rabipour, Mimma Mason, Neils Birbaumer, Bethanie Gouldthorp, Mike Anderson

Health Sciences Papers and Journal Articles

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To assess the effectiveness of EEG neurofeedback as treatment for inhibition and updating problems in children facing neurodevelopmental challenges.

Development Of A Theory-Informed Implementation Intervention To Improve The Triage, Treatment And Transfer Of Stroke Patients In Emergency Departments Using The Theoretical Domains Framework (Tdf): The T3 Trial, Louise E. Craig, Natalie Taylor, Rohan Grimley, Dominique A. Cadilhac, Elizabeth Mcinnes, Rosemary Phillips, Simon Dale, Denise O'Connor, Chris Levi, Mark Fitzgerald, Julie Considine, Jeremy M. Grimshaw, Richard Gerraty, N. Wah Cheung, Jeanette Ward, Sandy Middleton

Health Sciences Papers and Journal Articles

Background: Theoretical frameworks and models based on behaviour change theories are increasingly used in the development of implementation interventions. Development of an implementation intervention is often based on the available evidence base and practical issues, i.e. feasibility and acceptability. The aim of this study was to describe the development of an implementation intervention for the T3 Trial (Triage, Treatment and Transfer of patients with stroke in emergency departments (EDs)) using theory to recommend behaviour change techniques (BCTs) and drawing on the research evidence base and practical issues of feasibility and acceptability.

Methods: A stepped method for developing complex interventions based …

Neuromuscular Training Improves Movement Competency And Physical Performance Measures In 11-13 Year Old Female Netball Athletes, A Hopper, E Haff, O Barley, C Joyce, R Lloyd, G Haff

Health Sciences Papers and Journal Articles

The purpose of this study was to examine the effects of a neuromuscular training program on movement competency and measures of physical performance in youth female netball players. It was hypothesized that significant improvements would be found in movement competency and physical performance measures following the intervention. Twenty-three junior female netball players (age, 12.17 ± 0.94 yrs; height, 1.63 ± 0.08 m; weight, 51.81 ± 8.45 kg) completed a test battery before and after a six-week training intervention. 13 of these athletes underwent six weeks of neuromuscular training, which incorporated plyometrics and resistance training. Trained athletes showed significant improvements in …

Reducing Falls After Hospital Discharge: Protocol For A Randomised Controlled Trial Evaluating An Individualised Multi-Modal Falls Education Program For Older Adults, A. Hill, C. Etherton-Beer, S. Mcphail, M. Morris, L. Flicker, R. Shorr, M. Bulsara, D. Lee, J. Francis-Coad, N. Waldron, A. Boudville, T. Haines

Health Sciences Papers and Journal Articles

Introduction: Older adults frequently fall after discharge from hospital. Older people may have low self-perceived risk of falls and poor knowledge about falls prevention. The primary aim of the study is to evaluate the effect of providing tailored falls prevention education in addition to usual care on falls rates in older people after discharge from hospital compared to providing a social intervention in addition to usual care.

Methods and analyses: The ‘Back to My Best’ study is a multisite, single blind, parallel-group randomised controlled trial with blinded outcome assessment and intention-to-treat analysis, adhering to CONSORT guidelines. Patients (n=390) (aged 60 …

Birth Experience Of Fathers In The Setting Of Teenage Pregnancy: Are They Prepared?, Simeon Ngweso, Rodney W. Petersen, Julie Quinlivan

Health Sciences Papers and Journal Articles

Aim: To explore the birth experiences of teenage fathers and determine the extent to which they are prepared for childbirth.

Methods: A mixed methods observational study was undertaken comparing the birth experience of 50 fathers in the setting of teenage pregnancy (teenage) compared to a group of 50 older fathers. Fathers were recruited in the antenatal period and completed structured questionnaires following the birth of their child. Quantitative and qualitative analysis was undertaken.

Results: Teenage fathers were younger, less educated and less likely to attend prenatal childbirth education classes (P < 0.0001). During birth, they were less prepared and consulted by attending staff (both P < 0.05). They reported limited roles in intrapartum decision-making (< 20%). In multivariate analysis being a father in the setting of teenage pregnancy remained significantly associated with feeling unprepared for birth. The major themes in qualitative analysis were feeling unprepared, shock, fear, a sense of detachment, happiness, pride, love of the baby and satisfaction with fertility.

Conclusion: Teenage fathers are less prepared for the …

Patient Predictors Of Poor Drug Sensitive Tuberculosis Treatment Outcomes In Kyiv Oblast, Ukraine, Omowunmi Aibana, Andrej Slavuckij, Mariya Bachmaha, Viatcheslav Krasiuk, Natasha Rybak, Timothy P Flanigan, Vasyl Petrenko, Megan B Murray

Faculty, Staff and Student Publications

Background: Ukraine has high rates of poor treatment outcomes among drug sensitive tuberculosis (DSTB) patients, while global treatment success rates for DSTB remain high.

We evaluated baseline patient factors as predictors of poor DSTB treatment outcomes.

Methods: We conducted a retrospective analysis of new drug sensitive pulmonary TB patients treated in Kyiv Oblast, Ukraine between November 2012 and October 2014. We defined good treatment outcomes as cure or completion and poor outcomes as death, default (lost to follow up) or treatment failure. We performed logistic regression analyses, using routine program data, to identify baseline patient factors associated with poor outcomes. …

Genetic Diversity And Population Structure Of The African Catfish, Clarias Gariepinus (Burchell, 1822) In Kenya: Implication For Conservation And Aquaculture, James E. Barasa, Sinebongo Mdyogolo, Romulus Abila, Johannes Paul Grobler, Robert A. Skilton, Hesmari Bindeman, Moses Ndotono Njahira, Emily J. Chemoiwa, Otto G. Dangasuk, Boaz Kaunda-Arara, Erik Verheyen

All Peer-Reviewed Publications

African catfish, Clarias gariepinus, is an important species in aquaculture and fisheries in Kenya. Mitochondrial D-loop control region was used to determine genetic variation and population structure in samples of C. gariepinus from 10 sites including five natural populations (Lakes Victoria (LVG), Kanyaboli (LKG), Turkana (LTA), Baringo (LBA) and Jipe (LJP), and five farms (Sangoro Aquaculture Center (SAN), Sagana Aquaculture Centre (SAG), University of Eldoret Fish Farm (UoE), Kibos Fish Farm (KIB), and Wakhungu Fish Farm (WKU)) in Kenya. Similarly, samples from eight localities (four natural populations: LVG/LKG, LTA, LBA, and four farmed: SAN, SAG, KIB, UoE) were genotyped using …

Telehealth And Ehealth In Nurse Practitioner Training: Current Perspectives, Carolyn M. Rutledge, Karen Kott, Rebecca Poston, Christianne Fowler, Tina S. Haney

Ellmer School of Nursing Faculty Publications

Telehealth is becoming a vital process for providing access to cost-effective quality care to patients at a distance. As such, it is important for nurse practitioners, often the primary providers for rural and disadvantaged populations, to develop the knowledge, skills, and attitudes needed to utilize telehealth technologies in practice. In reviewing the literature, very little information was found on programs that addressed nurse practitioner training in telehealth. This article provides an overview of both the topics and the techniques that have been utilized for training nurse practitioners and nurse practitioner students in the delivery of care utilizing telehealth. Specifically, this …

Dna Methylation Patterns In Cord Blood Of Neonates Across Gestational Age Association With Cell-Type Proportions, Susan M. Braid, Kwame Okrah, Amol Shetty, Hector Corrada Bravo

Ellmer School of Nursing Faculty Publications

Background: A statistical methodology is available to estimate the proportion of cell types (cellular heterogeneity) in adult whole blood specimens used in epigenome-wide association studies (EWAS). However, there is no methodology to estimate the proportion of cell types in umbilical cord blood (also a heterogeneous tissue) used in EWAS.

Objectives: The objectives of this study were to determine whether differences in DNA methylation (DNAm) patterns in umbilical cord blood are the result of blood cell type proportion changes that typically occur across gestational age and to demonstrate the effect of cell type proportion confounding by comparing preterm infants exposed and …

A Decade Of Diabetes Hospitalizations: Meaningful Information For Community-Based Health Services Administrators For Identifying And Assessing Risk, Jewel Shepherd, Koren Goodman, Manasi Sheth-Chandra

Ellmer School of Nursing Faculty Publications

The American Diabetes Association has established that the largest contributor of expenditures related to the cost of care for diabetes is inpatient hospital care. Research has shown that when multiple hospitalizations have been examined, patients diagnosed with diabetes have higher same year readmission rates. Medicare-enrolled patients with coronary artery disease and diabetes who participated in a diabetes management intervention that included self-care behavior instructions and nurse management had fewer emergency room visits and hospitalizations for diabetes related care. In the US, an aging population and expected changes in the ethnic composition prompts an alert to actively address the need for …

Holistic Self-Care: Tai Chi, Qigong Training For Caregivers At An Alzheimer Disease Assisted Living Facility, Sunny Alperson, Christianne Fowler

Ellmer School of Nursing Faculty Publications

With the growing number of older persons with chronic illnesses, the demand for professionals who can provide complex care is increasing as well. However, evidence shows that health professionals’ burnout rate has been consistently increasing for the last 3 decades. In an effort to alleviate some of the issues associated with caregiver burnout, we conducted mind-body training of self-compassion for professional caregivers at an Alzheimer disease (AD) specialty center for 5 weeks. The intervention combined seven simple centering movements of tai chi and qigong in a context of mettā (loving kindness meditation) language mindfulness. Data showed significant improvements in caregiver …

Heme Oxygenase 1 Expression After Traumatic Brain Injury And Effect Of Pharmacological Manipulation On Functional Recovery., Nicholas H. Russell

Theses and Dissertations

Traumatic Brain Injury (TBI) is an increasingly diagnosed constellation of injuries derived from acute mechanical trauma to the brain. With the rise of advanced neuroimaging techniques recent focus has oriented primarily towards the mild-moderate range of TBI which previously was missed diagnostically. Characteristically, these advances have shown increasing areas of micro-hemorrhage in susceptible areas of the brain and to date there are no treatment modalities targeting micro-hemorrhages or their sequelae. This dissertation explores the effects of the resulting heme processing response in the days following injury with a particular focus on inducing early heme clearance from the parenchyma using a …

Implementing Integrated Care In Family Medicine: Description And Outcomes In An Underserved Population, Zach Radcliff

Theses and Dissertations

Introduction: Family physicians provide access to medical and behavioral healthcare for many underserved populations. Integrating behavioral health clinicians into primary care practices has been proposed as one of the most effective ways to increase access to necessary behavioral health services for many Americans. Integrated behavioral healthcare (IBHC) has begun to be implemented in family medicine practices but there is limited research examining the impact for patients and clinic staff. This study begins to fill this gap in the literature by examining the effects of implementing integrated behavioral healthcare in an urban family medicine clinic in a medically underserved area.

Objective: …

The Relationships Between Fluoride Intake Levels And Fluorosis Of Late‐Erupting Permanent Teeth, Pradeep Bhagavatula, Alexandra Curtis, Barbara Broffitt, Karin Weber-Gasparoni, John J. Warren, Steven M. Levy

School of Dentistry Faculty Research and Publications

Objectives

To examine the relationships between fluoride intake levels and fluorosis of late‐erupting permanent teeth.

Methods

The current study used information collected from 437 children in the longitudinal Iowa Fluoride Study. Participants' fluoride intake information was collected using questionnaires from birth to age 10 years. Estimated mean daily fluoride intake was categorized into low, moderate, and high intake tertiles for each age interval (2‐5, 5‐8, and 2‐8 years). Bivariate analyses were performed to study the relationships between self‐reported fluoride intake levels during three age intervals and dental fluorosis.

Results

For canines and second molars, the prevalence of mostly mild fluorosis …

Role Of Translation Initiation In Regulation Of Epithelial Junctions And Cell Motility, Fahda Fawaz Alsharief

Theses and Dissertations

The integrity and barrier properties of intestinal epithelium are determined by specialized adhesive structures known as intercellular junctions; composed of adherens junctions (AJs), tight junctions (TJs) and focal adhesions that mediate cell-cell and cell matrix interactions, respectively. These two types of epithelial cell adhesions regulate each other during disruption and restitution of the epithelial barrier. Inflammatory cytokines such as interferon gamma (IFNγ) and tumor necrosis factor alpha (TNFα) are elevated during intestinal inflammation. The most notable effects of IFNγ and TNFα on intestinal epithelial homeostasis involve disruption of apical junctions and attenuation of cell migration. Although molecular mechanisms underlying these …

Investigation Of Anticoagulation Properties Of Sulfated Glycosaminoglycan Mimetics, Elsamani I. Abdelfadiel

Theses and Dissertations

Abstract

INVESTEGATION OF ANTICOAGULATION PROPERTIES OF SULFATED

GLYCOSAMINOGLYCAN MIMETICS

By Elsamani Ismail Abdelfadiel, MS

A thesis submitted in partial fulfillment of the requirements for the degree of Master of

Science at Virginia Commonwealth University

Virginia Commonwealth University, 2017.

Supervisor: Umesh R Desai

Professor, Department of Medicinal Chemistry

The existence of thrombosis in numerous pathophysiological situations formed a vast necessity for anticoagulation therapy. Thrombin and factor Xa are the only two factors of the entire coagulation cascade that have been major targets for regulation of clotting via the direct and indirect mechanism of inhibition. Our recent discovery of sulfated non-saccharide glycosaminoglycan …