Medicine and Health Sciences Commons^™

Relative Associations Of Age, Height, And Weight On Sinus Of Valsalva And Mid-Ascending Aorta: An Imaging And Epidemiology Study, Mirza Nubair Ahmad, Syed Haris Pir, Mirza Mujadil Ahmad, Sharmeen Hussaini, Bijoy K. Khandheria, A. Jamil Tajik, Khawaja Afzal Ammar

Journal of Patient-Centered Research and Reviews

Background: Prior studies show ascending aorta diameter varies with age, height and weight, but they did not evaluate relative influence of these variables on aortic diameter. Since height is genetically determined, and genetic disorders like Marfan syndrome are predominantly associated with sinus of Valsalva (SOV) dilation, we hypothesized height may have stronger association with SOV.

Purpose: Based on anecdotal observation, since age, weight and obesity are acquired attributes, we hypothesized age, weight and body mass index may have greater association with mid-ascending aorta (MAA) diameter, even in normal patients.

Methods: We evaluated echocardiographic studies of patients ≥ 15 years old …

Antibiotic Stewardship: The Role Of Clinical Nurses And Nurse Educators, Sharon Sumner, Sandra Forsyth, Katreena Collette Merrill, Caroline Taylor, Todd Vento, John Veillette, Brandon Webb

Faculty Publications

Within 10 years of the breakthrough development of Penicillin, antibiotic resistance was reported. According to the Centers for Disease Control (CDC) and Prevention (CDC, 2017), each year 2 million cases of antibiotic resistant bacteria occur resulting in approximately 23,000 deaths in the United States. The World Health Organization (WHO) also reports that approximately 25,000 people die from antibiotic resistant organisms annually in the European Union (WHO, 2014). To combat these alarming trends, antibiotic stewardship (AS) programs have been strongly recommended by the WHO, the National Institute for Health and Care Excellence (NICE) Centers for Disease Control and Prevention (CDC), the …

Musical Hallucinations Treated With Atypical Antipsychotics In A Geriatric Population – A Case Series, Adam Schindzielorz Md, D. Scott Murphy Md, Suzanne Holroyd Md

Psychiatry

Musical hallucinations have been likened to the auditory equivalent of Charles Bonnet Syndrome, which involves complex visual hallucinations, most often in the context of visual impairment. Musical hallucination frequently take the form of hymns, carols, and show-tunes and are strongly associated with hearing loss, with some studies suggesting a prevalence of 2.5–3.6% in the hearing impaired. Musical hallucinations are typically treated with anticonvulsant and anticholinesterase medications, with some studies having evaluated the efficacy of sedative hypnotics, antipsychotics and antidepressants in various psychiatric and medical subpopulations suggesting a heterogeneous spectrum of causes for this disorder.

We present two cases of musical …

Medical School Watercooler Newsletter - November 5, 2017, Lindsey Lyle

Watercooler Newsletter

This is the November 5, 2017 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

Physicians Group, College of Medicine Employees Named to USA-Team

USA Medical Students Perform in Top Quartile of Medical Students Across the United States

USA Welcomes New Orthopaedic Surgery Chair

Dr. Bassam Presents at AANEM Annual Meeting

Tobacco's Minor Alkaloids: Effects On Place Conditioning And Nucleus Accumbens Dopamine Release In Adult And Adolescent Rats, Julie A. Marusich, Mahesh Darna, A. George Wilson, Emily D. Denehy, Amanda Ebben, Agripina G. Deaciuc, Linda P. Dwoskin, Michael T. Bardo, Timothy W. Lefever, Jenny L. Wiley, Chad J. Reissig, Kia J Jackson

Pharmaceutical Sciences Faculty Publications

Tobacco products are some of the most commonly used psychoactive drugs worldwide. Besides nicotine, alkaloids in tobacco include cotinine, myosmine, and anatabine. Scientific investigation of these constituents and their contribution to tobacco dependence is less well developed than for nicotine. The present study evaluated the nucleus accumbens dopamine-releasing properties and rewarding and/or aversive properties of nicotine (0.2-0.8 mg/kg), cotinine (0.5-5.0 mg/kg), anatabine (0.5-5.0 mg/kg), and myosmine (5.0-20.0 mg/kg) through in vivo microdialysis and place conditioning, respectively, in adult and adolescent male rats. Nicotine increased dopamine release at both ages, and anatabine and myosmine increased dopamine release in adults, but not …

Memory Care Residents And Indoor Ecotherapy, Robert C. Rados, Jun Kim

ASA Multidisciplinary Research Symposium

The positive benefits of this study support the use of “indoor ecotherapy” as an intervention, and as an alternative to use of medications, for resident residing in a memory care facility.

Perspectives Of Executives And Students On Leadership Characteristics For Healthcare Managers: Does A Gap Exist?, Marcea Walter

ASA Multidisciplinary Research Symposium

Preparing healthcare managers for the complexity of the healthcare industry poses a heavy challenge on healthcare organizations, CEOs, managers, and educational institutions. In order to ensure that future healthcare managers are prepared to enter the workforce, it is important that the characteristics and skills deemed important by current CEOs in the field are similar to those of undergraduate healthcare management students that will be entering the workforce.

Individual And Community Well-Being In Nonmetropolitan Nebraska: 2017 Nebraska Rural Poll Results, Rebecca J. Vogt, Cheryl A. Burkhart-Kriesel, Randolph L. Cantrell, Bradley Lubben, L. J. Mcelravy, T. L. Meyer

Rural Futures Institute: Publications

Conclusion

By many different measures, rural Nebraskans are positive about their community. Many rural Nebraskans rate their community favorably on its social dimensions: as friendly, trusting and supportive. Most rural Nebraskans say it would be difficult to leave their community and have a positive attachment to their community. And, most rural Nebraskans disagree that their community is powerless to control its future.

Across all years of this study, rural Nebraskans’ views about the change in their community have generally been positive. The proportion believing their community has changed for the better during the past year has usually been greater than …

Borders And Blood Pressure: Understanding The Role Of Acculturation In A Hypertension Diagnosis Among Hispanic Americans: 2014 California Health Interview Survey, Lia Scalzo, Mph, Hee-Soon Juon, Phd, Msn, Russell K. Mcintire, Phd, Mph

College of Population Health Posters

Background:

In the U.S. Hispanic population overall, heart disease is the leading cause of death. The prevalence of hypertension among Mexican American immigrants is lower than the general population, yet it is on the rise. Health risks among Hispanics vary depending on their length of stay in the US (as proxy measure of acculturation). The purpose of this study was to examine the association between acculturation and the individual's likelihood of being diagnosed with hypertension among Hispanic Americans.

Methods:

We used data from the 2014 California Health Interview Survey (CHIS) and performed univariate analysis to examine racial differences in prevalence …

Climate Change And Resulting Floods: Using Social Capital To Strengthen Community Resilience In Eastwick, Philadelphia A Known Floodplain, Natasha Bagwe, Md, Mph, Richard Pepino, Phd, Mss, Erin Johnson, Mph, Msn, Rn, Julie Becker, Phd, Mph

College of Population Health Posters

• Climate change will produce intense weather events like increased precipitation and flooding

• Based on climate projections, Philadelphia will be hotter and wetter, and will experience more frequent and intense weather events (OOS, 2016)

•Floods are the second most common hazards in our city (OEM, 2017)

• Vulnerable population such as children, people of color, elderly population and people with disability are severely impacted by climate change

Poster presented at AHPA conference in Atlanta Georgia, United States.

Deficiency Of Klf4 Compromises The Lung Function In An Acute Mouse Model Of Allergic Asthma, Jeanette A. Nimpong, Wintana Gebregziabher, Udai P. Singh, Prakash Nagarkatti, Mitzi Nagarkatti, Johnie Hodge, Chunming Liu, Daping Fan, Walden Ai

Molecular and Cellular Biochemistry Faculty Publications

Asthma is a chronic inflammatory disease of the airways and the mechanisms are not fully understood. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of monocytes, granulocyte and myeloid cells at early stage of differentiation. They possess phenotypic plasticity and regulate airway inflammation. We recently reported that Kruppel-like factor 4 (KLF4) regulates MDSC differentiation into fibrocytes, emerging effectors in chronic inflammation. However, the role of KLF4 in asthma is not known. Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine and a key initiator of allergic airway inflammation. Given the fact that TSLP promotes Th2 cytokine production that increases MDSC …

Time In Therapeutic Range, As A Determinant Of All-Cause Mortality In Patients With Hypertension., Michael Doumas, Costas Tsioufis, Ross Fletcher, Richard Amdur, Charles Faselis, Vasilios Papademetriou

Medicine Faculty Publications

BACKGROUND: Accumulating evidence indicates that reducing systolic blood pressure (BP) tooutcomes; however, an optimal level has not yet been determined. Many population studies or post hoc analyses suggest a target systolic BP between 120 and 140 mm Hg with increased risk above and below that range. We tested the hypothesis that consistent control of systolic BP between 120 and 140 mm Hg-time in therapeutic range-is a strong determinant of all-cause mortality among US veterans.

METHODS AND RESULTS: A total of 689 051 individuals from 15 Veterans Administration Medical Centers were followed over a 10-year period. Participants were classified as hypertensive, …

How Did I Get Here? Testing The Translation Of The Morris Water Maze And The Influence Of Hemoglobin A1c On Spatial Navigation Performance, Colleen Pappas

USF Tampa Graduate Theses and Dissertations

Changes in cognitive status occur with aging and significant attention has been placed on developing interventions to possibly delay cognitive decline and identifying risk factors that exacerbate cognitive deficits. One issue that arises when studying interventions is that they do not always effectively translate from animal models to human subjects. When testing potentially modifiable risk factors related to cognitive impairment, more sensitive metrics could help in identifying targets for intervention at earlier time-points. Therefore, the aims of the current dissertation were twofold. The first study examined the ability to translate between species using a common behavioral paradigm, the Morris water …

Environmental Health News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• Georgia Southern Student Wins Presentation Award at Southeast SETAC
• Georgia Southern Examines Aerosolized Bacteria and Microbial Activity in Dental Clinics

The Need For A Network To Establish And Validate Predictive Biomarkers In Cancer Immunotherapy., Giuseppe V Masucci, Alessandra Cesano, Alexander Eggermont, Bernard A Fox, Ena Wang, Francesco M Marincola, Gennaro Ciliberto, Kevin Dobbin, Igor Puzanov, Janis Taube, Jennifer Wargo, Lisa H Butterfield, Lisa Villabona, Magdalena Thurin, Michael A Postow, Paul M Sondel, Sandra Demaria, Sanjiv Agarwala, Paolo A Ascierto

Articles, Abstracts, and Reports

Immunotherapies have emerged as one of the most promising approaches to treat patients with cancer. Recently, the entire medical oncology field has been revolutionized by the introduction of immune checkpoints inhibitors. Despite success in a variety of malignancies, responses typically only occur in a small percentage of patients for any given histology or treatment regimen. There are also concerns that immunotherapies are associated with immune-related toxicity as well as high costs. As such, identifying biomarkers to determine which patients are likely to derive clinical benefit from which immunotherapy and/or be susceptible to adverse side effects is a compelling clinical and …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern Assesses Training Needs and Competency Gaps In Food Protection Staff
• Georgia Southern Student Wins Presentation Award at Southeast SETAC
• Georgia Southern Examines Aerosolized Bacteria and Microbial Activity in Dental Clinics

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Georgia Southern Assesses Training Needs and Competency Gaps in Food Protection Staff

Extra-Pleural Dermal Solitary Fibrous Tumor On The Posterior Shoulder: A Case Report., Sean J. Wallace Md, Robert Teixeira Md, Nathan F. Miller, Hina A. Sheikh, Genevieve Guzman, Rohit Sharma Md

Department of Surgery

No abstract provided.

Plasma Brain-Derived Neurotrophic Factor Levels In Newborn Infants With Neonatal Abstinence Syndrome, Lochan Subedi, Hong Huang, Amrita Pant, Philip M. Westgate, Henrietta S. Bada, John A. Bauer, Peter J. Giannone, Thitinart Sithisarn

Pediatrics Faculty Publications

Background: Brain-derived neurotrophic factor (BDNF) is a type of growth factor that promotes growth and survival of neurons. Fetal exposure to opiates can lead to postnatal withdrawal syndrome, which is referred as neonatal abstinence syndrome (NAS). Preclinical and clinical studies have shown an association between opiates exposure and alteration in BDNF expression in the brain and serum levels in adult. However, to date, there are no data available on the effects of opiate exposure on BDNF levels in infant who are exposed to opiates in utero and whether BDNF level may correlate with the severity of NAS.

Objective: To compare …

Predicting Hand Surface Area From A Two-Dimensional Hand Tracing, Myles O'Mara

USF Tampa Graduate Theses and Dissertations

Recent occupational health studies have focused on dermal exposure at the hands, but have been unable to accurately express dose without knowing the HSA. There is no standard method to calculate HSA, though some researchers have derived HSA formulas based on dimensions from a Taiwanese population. This research paper describes a shortcut method to estimate the hand surface area (HSA) of a human hand from a two-dimensional hand tracing, and repeated a Taiwanese HSA study in order to explore the viability of its HSA formula in an American university population. A sample of nine adult men and nine adult women, …

An Exploration Of Social Determinants Of Health Constructs As Potential Mediators Between Disability And Condom Usage, Karina Pineda

USF Tampa Graduate Theses and Dissertations

There is limited knowledge on the sexual health behaviors of young adults with physical disabilities, as people with disabilities have traditionally been treated homogenously without acknowledgement of the potential differences between disability types. The objective of this study was twofold. The first goal was to take a novel approach by guidance of the Social Determinants of Health (SDOH) framework to compare how young adults with physical disabilities compare against those without physical disabilities in: 1) vaginal sexual activity, 2) condom usage, and 3) the effect of SDOH factors as potential mediators in predicting unprotected vaginal sex. Relatedly, the second goal …

College Students, Experiences On Smart Phone Technology Usage: A Qualitative Content Analysis Study, Fatemeh Jafarzadeh-Kenarsari, Parand Pourghane

The Qualitative Report

Besides many benefits of the cell phone technology, numerous arguments are raised on the different and important negative effects of such a technology. This qualitative content analysis study explored the common usages of smart phone technology, its challenges, and benefits among Iranian college students. Participants were 32 bachelor degree students who were recruited using purposive sampling method with maximum variation. Data were collected through 11 individual semi-structured interviews and 3 focus group discussions (5-8 students in each group). Data analysis was done based on a conventional content analysis approach. Data analysis resulted in 3 main themes and 12 sub-themes. The …

Research Brief: "Service Delivery Experiences And Intervention Needs Of Military Families With Children With Asd", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This study describes the service delivery challenges and intervention needs of military families that include children with autism spectrum disorder (ASD) who have relocated. In practice and policy, military families with children with ASD living on a military base should consider serving as a mentor to new families on the base to offer information on schools and community resources, and would also benefit from the increased accessibility of resources by the Department of Defense (DoD). More research is needed to learn the best practices of service delivery for military families with children with ASD, and future studies on service delivery …

Association Between Ideal Cardiovascular Health Metrics And Suboptimal Health Status In Chinese Population, Youxin Wang, Xiaoxue Liu, Jing Qiu, Hao Wang, Di Liu, Zhongyao Zhao, Manshu Song, Qiaofeng Song, Xizhu Wang, Yong Zhou, Wei Wang

Research outputs 2014 to 2021

Suboptimal health status (SHS) is a physical state between health and illness, and previous studies suggested that SHS is associated with majority components of cardiovascular health metrics defined by American Heart Association (AHA). We investigated the association between SHS and cardiovascular health metrics in a cross-sectional analysis of China suboptimal health cohort study (COACS) consisting of 4313 participants (60.30 % women) aged from 18 to 65 years old. The respective prevalence of SHS is 7.10 %, 9.18 %, 10.04 % and 10.62 % in the first, second, third and fourth quartiles of ideal cardiovascular health (CVH) metrics (P for …

Post-Pericardiotomy Syndrome Disguised As Fever Of Unknown Origin, Ida Micaily, Md, Bilal Lashari, Md, Aditya Munshi, Md, Zulfiqar Arif, Md

Division of Internal Medicine Faculty Papers & Presentations

Introduction:

Post -Pericardiotomy syndrome (PPS) is a clinical diagnosis characterized by fever, pericardial or pleural effusions, and a pericardial friction rub occurring over several days after cardiac surgery.

The infrequency of PPS can cause delay in recognition and management, thus leading to significant morbidity.

We present a case of fever of unknown origin, pericardial and pleural effusion secondary to postpericardiotomy syndrome 10 days after an Aortic Valve Replacement (AVR)

Poster presented at: American College of Physicians Southeast Regional Meeting on October 15th, 2016

Medical Response Times And Their Effect On Prehospital Care, Storm Santos

Scholars Week

Medical Response Times and Their Effect on Prehospital Care

Storm J. Santos, Rural Health Scholar

Dr. Naber, Faculty Advisor

Department of Health Sciences

Abstract

Medical emergencies happen in a variety of different environments. Each environment comes with unique challenges that emergency medical responders must work through to safely alleviate any given medical emergency. This study examines the effect of medical team response times on the overall care of the patient as well as if population density (rural vs urban) further affects the overall care of the patient. This study was inspired by works that compared various environmental factors and their …

The Santa Clara, 2017-11-02, Santa Clara University

The Santa Clara

No abstract provided.

Suicide Behavior Among Guyanese Orphans: Identification Of Suicide Risk And Protective Factors In A Low-Middle-Income-Country, Ellen-Ge Denton, George Musa, Christina Hoven

Publications and Research

Objective: Suicide is the leading cause of death among youth in Guyana, a low- and middle-income country (LMIC), which globally ranks first in female adolescent suicides over the last decade. Worldwide, Guyana has experienced the largest increase in youth suicide, despite focused public health efforts to reduce suicide. Further, youth in Guyana, who are clients of the orphanage system and have faced early childhood trauma, may have an additive risk for suicide. Guided by an ideation-to-action theoretical framework for suicide prevention, the goal of the proposed research study is to describe and identify risk and protective factor correlates of …

Computational Study Targeting Anti-Fungal Tavaborole Analogs And Anti-Cancer Braco19, Babitha Machireddy

Theses and Dissertations

This thesis comprises of three computer aided drug design studies utilizing molecular docking and molecular dynamic simulations: (i) a lead optimization study virtually screening an initial library of ~120000 lead compounds targeting fungal leucyl tRNA synthetase, (ii) an exploratory study to understand the binding pathway of BRACO19 to a parallel telomeric DNA G-quadruplex by MD simulations and compare with experimentally solved X-ray crystal structure (iii) a comparative study to understand the lack of selectivity of BRACO19 to various topologies of human telomeric DNA G-quadruplex over DNA duplex.

The first chapter provides the background information required to understand the molecular docking …

Moonlighting Newborn Screening Markers: The Incidental Discovery Of A Second-Tier Test For Pompe Disease, Silvia Tortorelli, Jason S. Eckerman, Joseph J. Orsini, Colleen Stevens, Jeremy Hart, Patricia L. Hall, John J. Alexander, Dimitar Gavrilov, Devin Oglesbee, Kimiyo Raymond, Dietrich Matern, Piero Rinaldo

Pathology and Laboratory Medicine Faculty Publications

Purpose: To describe a novel biochemical marker in dried blood spots suitable to improve the specificity of newborn screening for Pompe disease.

Methods: The new marker is a ratio calculated between the creatine/creatinine (Cre/Crn) ratio as the numerator and the activity of acid α-glucosidase (GAA) as the denominator. Using Collaborative Laboratory Integrated Reports (CLIR), the new marker was incorporated in a dual scatter plot that can achieve almost complete segregation between Pompe disease and false-positive cases.

Results: The (Cre/Crn)/GAA ratio was measured in residual dried blood spots of five Pompe cases and was found to be elevated (range 4.41–13.26; 99%ile …