Medicine and Health Sciences Commons^™

Breastfeeding And Motor Development: A Longitudinal Cohort Study, T Grace, W Oddy, M Bulsara, B Hands

Health Sciences Papers and Journal Articles

Background: While there is a large body of work supporting the importance of early feeding practices on cognitive, immunity, behavioural and mental outcomes, few longitudinal studies have focused on motor development. The relationship between duration of breast feeding and motor development outcomes at 10, 14, and 17 years were examined.

Methods: Data were obtained from the Western Australian Pregnancy (Raine) Study. There were 2868 live births recorded and children were examined for motor proficiency at 10 (M = 10.54, SD = 2.27), 14 (M = 14.02, SD = 2.33) and 17 (M = 16.99, SD = 2.97) years using the …

Idiopathic Pulmonary Fibrosis And A Role For Autoimmunity, G Hoyne, H Elliott, S Mutsaers, C Prele

Health Sciences Papers and Journal Articles

Idiopathic Pulmonary Fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias. It is typically associated with extensive and progressive fibrosis, is fatal and has limited treatment options. Characteristically IPF patients display large lymphocyte aggregates composed of CD3+ T cells and CD20+ B cells within the lung tissue that are located near sites of active fibrosis. In addition, IPF patients can have autoantibodies to a range of host antigens, suggesting a breakdown in immunological tolerance. In this review we examine the role of T and B cells in IPF pathogenesis and discuss how loss of self- tolerance to lung …

The Relationship Between Repeated Kicking Performance And Maximal Aerobic Capacity In Elite Junior Australian Football, J Joseph, C Woods, C Joyce

Health Sciences Papers and Journal Articles

Australian football (AF) is a physically demanding game, requiring players to engage in a range of anaerobic activities interspersed with prolonged aerobic exercise. Coupled, players have to perform a range of technical skills, the most fundamental of which being to effectively kick (dispose) the ball. The aim of this study was to ascertain the extent to which aerobic capacity influenced kicking performance in AF. Twenty four elite U18 players competing in the same U18 competition performed the Australian Football Kicking test (AFK) three times with the yo-yo IR2 completed twice (between each AFK), with no rest between all three AFKs. …

The Association Between Secondary Mathematics And First Year University Performance In Health Sciences, C Joyce, G Hine, R Anderton

Health Sciences Papers and Journal Articles

In recent years, there has been a significant decline in the rate of participation in secondary school mathematics courses within Australia, particularly in advanced or higher level mathematics. The aim of this study was to investigate how grade point average (GPA) differed between five health science degrees at an Australian university. The association between Australian Tertiary Admission Ranking (ATAR), the level of mathematics completed at secondary school and GPA was also investigated. Results showed that students studying Biomedical Sciences and Physiotherapy had significantly higher GPA and ATAR than students studying Exercise and Sports Science, Physical Education, and Nursing. A higher …

Excisional Treatment In Women With Cervical Adenocarcinoma In Situ (Ais): A Prospective Randomised Controlled Noninferiority Trial To Compare Ais Persistence/Recurrence After Loop Electrosurgical Excision Procedure With Cold Knife Cone Biopsy: Protocol For A Pilot Study, Paul A. Cohen, Alison Brand, Peter Sykes, David C.H. Wrede, Orla Mcnally, Lois Eva, Archana Rao, Michael Campion, Martin Stockler, Aime Powell, Jim Codde, Max Bulsara, Lyndal Anderson, Yee Leung, Louise Farrell, Pennie Stoyles

Health Sciences Papers and Journal Articles

Introduction: Adenocarcinoma in situ (AIS) of the uterine cervix is the precursor to invasive endocervical adenocarcinoma. An excisional biopsy such as a cold knife cone biopsy (CKC) should be performed to exclude invasive adenocarcinoma. Loop electrosurgical excision procedure (LEEP) is an alternative modality to CKC but is controversial in AIS. There is a perception that there is a greater likelihood of incomplete excision of AIS with LEEP because the depth of excised tissue tends to be smaller and the tissue margins may show thermal artefact which can interfere with pathology assessment. In the USA, guidelines recommend that any treatment modality …

Analysis Of Platelet-Rich Plasma Extraction Variations In Platelet And Blood Components Between 4 Common Commercial Kits, J. Fitzpatrick, Max Bulsara, M. Richardson, M. Zheng

Health Sciences Papers and Journal Articles

Background: Platelet-rich plasma (PRP) has been extensively used as a treatment in tissue healing in tendinopathy, muscle injury, and osteoarthritis. However, there is variation in methods of extraction, and this produces different types of PRP.

Purpose: To determine the composition of PRP obtained from 4 commercial separation kits, which would allow assessment of current classification systems used in cross-study comparisons.

Study Design: Controlled laboratory study.

Methods: Three normal adults each donated 181 mL of whole blood, some of which served as a control and the remainder of which was processed through 4 PRP separation kits: GPS III (Biomet Biologics), Smart-Prep2 …

Optimizing Patient Risk Stratification For Colonoscopy Screening And Surveillance Of Colorectal Cancer: The Role For Linked Data, David B. Preen, Iris Lansdorp-Vogelaar, Hooi C. Ee, Cameron Platell, Dayna R. Cenin, Lakkhina Troeung, Max Bulsara, Peter O'Leary

Health Sciences Papers and Journal Articles

No abstract available for this article.

Assessment Of R18, Cog1410, And App96-110 In Excitotoxicity And Traumatic Brain Injury, Li Shan Chiu, Ryan S. Anderton, Jane L. Cross, Vince W. Clark, Adam B. Edwards, Neville W. Knuckey, Bruno P. Meloni

Health Sciences Papers and Journal Articles

Cationic arginine-rich and poly-arginine peptides (referred to as CARPs) have potent neuroprotective properties in in vitro excitotoxicity and in vivo models of stroke. Traumatic brain injury (TBI) shares many pathophysiological processes as stroke, including excitotoxicity. Therefore, we evaluated our lead peptide, poly-arginine R18, with the COG1410 and APP96-110 peptides, which have neuroprotective actions following TBI. In an in vitro cortical neuronal glutamic acid excitotoxicity injury model, R18 was highly neuroprotective and reduced neuronal calcium influx, while COG1410 and APP96-110 displayed modest neuroprotection and were less effective at reducing calcium influx. In an impact-acceleration closed-head injury model (Marmarou model), R18, COG1410, …

Study Protocol For A Randomised Controlled Trial Evaluating The Effect Of Prenatal Omega-3 Lcpufa Supplementation To Reduce The Incidence Of Preterm Birth: The Orip Trial, Shao J. Zhou, Karen Best, Robert Gibson, Andrew Mcphee, Lisa Yelland, Julie Quinlivan, Maria Makrides

Health Sciences Papers and Journal Articles

Introduction: Preterm birth accounts for more than 85% of all perinatal complications and deaths. Seventy-five per cent of early preterm births (EPTBs) occur spontaneously and without identifiable risk factors. The need for a broadly applicable, effective strategy for primary prevention is paramount. Secondary outcomes from the docosahexaenoic acid (DHA) to Optimise Mother Infant Outcome trial showed that maternal supplementation until delivery with omega-3 (ω-3) long chain polyunsaturated fatty acid (LCPUFA), predominantly as DHA, resulted in a 50% reduction in the incidence of EPTB and an increase in the incidence of post-term induction or post-term prelabour caesarean section due to extended …

Middle School And High School Students Who Stutter: A Qualitative Investigation Of School Experiences, Tiffany Cobb

Wayne State University Dissertations

ABSTRACT

MIDDLE SCHOOL AND HIGH SCHOOL STUDENTS WHO STUTTER: A QUALITATIVE INVESTIGATION OF SCHOOL EXPERIENCES

by

TIFFANY COBB

MAY 2017

Advisor: Dr. Derek Daniels

Major: Speech-Language Pathology

Degree: Doctor of Philosophy

Purpose: The purpose of this study was to explore and further understand the ways in which middle school and high school students perceive their school experiences within the school environment.

School has an important impact on the social development of children (Milsom, 2006). Learning is not done individually as classrooms are inherently social places. This suggests that students do not learn alone, but rather in the presence of many …

Clinicopathology And Molecular Determinants Underlying Benign Breast And Breast Cancer Lesions, Andreana Holowatyj Holowatyj

Wayne State University Dissertations

Despite converging incidence rates for breast cancers by race, disparities in mortality persist where black women suffer from poorer prognosis compared to white counterparts. To understand the clinical, demographic, and molecular characteristics underlying these disparities, we examined differences among patients with breast cancer to understand the role of human epidermal growth factor receptor 2 (HER2) status, age, and race/ethnicity among women diagnosed with hormone receptor-positive breast cancer, and disparities in surgical therapy among female patients with early stage young-onset breast cancer. Benign breast disease, another known risk factor for breast cancer, includes a histological spectrum of lesions, could contribute to …

Understanding The Mechanism Of Oxidative Stress Generation By Oxidized Dopamine Metabolites: Implications In Parkinson's Disease, Nihar Mehta

Wayne State University Dissertations

Oxidation of dopamine to toxic metabolites is considered to be one of the prime factors involved in the death of dopaminergic neurons in Parkinson’s disease. Some dopamine oxidation products have the capability to redox cycle in the presence of molecular oxygen, further contributing to oxidative stress. Therefore, our aim here was to study the redox cycling of dopamine oxidized metabolites and elucidate the underlying mechanism by which they cause oxidative stress.

Redox reactions involve transfer of one or more electrons between two compounds

resulting in either oxidation or reduction. In redox cycling, a compound undergoes

alternate oxidation and reduction, transferring …

Analysis Of The Secondary Neurodegenerative Consequences Of Primary Oligodendrocyte Stress Through The Use Of The Novel Obiden Mouse Model, Daniel Zdzislaw Radecki

Wayne State University Dissertations

The work of this project was to develop, test and characterize a potential novel mouse model of the neurodegenerative disease Multiple Sclerosis (MS). Historically, MS has been identified as a primary autoimmune disease of the central nervous system (CNS). However, treatments based on this view have met with limited success, and in most cases, fail to prevent progression of MS from mild to moderate and severe forms. Original observations regarding axonal and neuronal pathology in the white and gray matter of the CNS were rediscovered in the 1990s. These observations indicated that even in the absence of the immune system, …

Estimating The Variables Of The Nonlinear Dynamical Theory Of Acute Cell Injury, Fika Tri Anggraini

Wayne State University Dissertations

This Dissertation is the first to estimate the variables D and S of the nonlinear theory of acute cell injury in hippocampal regions CA1 and CA3 using a rat model of global brain ischemia and reperfusion (I/R). D was estimated by quantifying protein aggregates using ubiquitin Western blotting. S was estimated by quantifying changes in polysomal mRNAs as measured by microarray chips. D and S time courses were sampled at 0.5, 8, 16, 24, 48, and 72 hrs of reperfusion after 10 min brain ischemia. CA1 dies and CA3 survives. The theory predicts D will be larger in CA1 and …

Pet Imaging Of Early Therapeutic Response In Solid Tumors, Stephanie J. Blocker

Wayne State University Dissertations

An important pillar of precision medicine for oncology is the ability to identify patients who respond to treatment early into their therapy. Positron emission tomography (PET) allows physicians and researchers to measure changes in tumor behavior prior to noticeable differences in morphology.

Objective: Determine the utility of multiple tracers for PET in assessing early changes in tumor activity that result from treatment.

Methods: Two tracers for PET were studied. 64Cu-labeled liposomes were used to assess changes in liposome delivery two solid colon tumors early into treatment with bevacizumab (Bev). 18F-FMAU thymidine analog (1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)thymine), was utilized to detect early response to …

Effects Of Conjugated Linoleic Acid And Metformin On Insulin Sensitivity In Obese Children: Randomized Clinical Trial, Nayely Garibay-Nieto, Gloria Queipo-García, Flor Alvarez, Mayra Bustos, Erendira Villanueva, Fernando Ramírez, Mireya León, Estibalitz Laresgoiti-Servitje, Juan Carlos Lopez Alvarenga, Ravi Duggirala

School of Medicine Publications

Context: Insulin resistance precedes metabolic syndrome abnormalities and may promote cardiovascular disease and type 2 diabetes in children with obesity. Results of lifestyle modification programs have been discouraging, and the use of adjuvant strategies has been necessary.

Objective: This study aimed to evaluate the effects of metformin and conjugated linoleic acid (CLA) on insulin sensitivity, measured via euglycemic-hyperinsulinemic clamp technique and insulin pathway expression molecules in muscle biopsies of children with obesity.

Design: A randomized, double-blinded, placebo-controlled clinical trial was conducted.

Setting: Children with obesity were randomly assigned to receive metformin, CLA, or placebo.

Results: Intervention had a …

Effect Of Pulse Shaping On Subharmonic Aided Pressure Estimation In Vitro And In Vivo., Ipshita Gupta, John R. Eisenbrey, Maria Stanczak, Anush Sridharan, Jaydev K. Dave, Ji-Bin Liu, Christopher Hazard, Xinghua Wang, Ping Wang, Huiwen Li, Kirk Wallace, Flemming Forsberg

Department of Radiology Faculty Papers

OBJECTIVES: Subharmonic imaging (SHI) is a technique that uses the nonlinear oscillations of microbubbles when exposed to ultrasound at high pressures transmitting at the fundamental frequency ie, f

METHODS: Eight waveforms with different envelopes were optimized with respect to acoustic power at which the SHAPE study is most sensitive. The study was run with four input transmit cycles, first in vitro and then in vivo in three canines to select the waveform that achieved the best sensitivity for detecting changes in portal pressures using SHAPE. A Logiq 9 scanner with a 4C curvi-linear array was used to acquire 2.5 MHz …

Development Of The Clinical Teaching Effectiveness Questionnaire In The United States, Michelle E. Wormley, Wendy Romney, Anna E. Greer

All PTHMS Faculty Publications

The purpose of this study was to develop a single valid measure for assessing clinical teaching effectiveness within the field of physical therapy. Pilot testing with CIs from both universities were purposively sampled to complete the questionnaire. The CI databases yielded 1,001 potential respondents, recruited via e-mail. The questionnaire and two follow-up reminders were sent. Respondents consented by clicking a link which redirected them to the SurveyMonkey® questionnaire. Two hundred five CIs completed the questionnaire, a 20.5% response rate. The 205 respondents were mostly female (68.4%) with an average age of 40.54 years (SD=10.22). CI experience was distributed as follows: …

Professional Nursing Value Development In Nursing Students Who Participate In International Service Learning, Heather Ferrillo

Nursing Faculty Publications

Background: International Service Learning (ISL) is becoming widely used in nursing education as a means to provide global learning opportunities. Concrete outcomes for these experiences have not been clearly supported in previous research. Determining if ISL experience facilitate the development of Professional Nursing Values (PNV) can support the use of ISL as a viable pedagogy. Purpose: The purpose of the study was to determine if there were a difference in PNV development in students who participate in ISL as part of their clinical experiences compared to those who do not. The hypothesis was that there was a difference in the …

Empowerment Of Home Health Care Case Managers, Linda B. Melodia, Barbara Penprase, Linda L. Strong

Nursing Faculty Publications

Background: Job satisfaction and feelings of empowerment positively impact home health care nurses by improving patient safety and patient outcomes. The project objective determined whether an empowerment educational module improved the feelings of empowerment and job satisfaction of registered nurses at a home health care agency. Methods: A quantitative, pre-test/post-test research study was conducted to measure the success of an empowerment educational module. Laschinger’s (2008) Nursing Worklife questionnaire was administered to 92 participating nurses, 46 were assigned to an experimental group and 46 were assigned to a control group. Participants in the experimental group were queried about their perceptions towards …

The Immediate Effects Of A Seated Versus Supine Upper Thoracic Spine Thrust Manipulation Compared To Sham Manipulation In Individuals With Subacromial Pain Syndrome – A Randomized Controlled Trial, Jason K. Grimes

Physical Therapy Faculty Publications

Background: Individuals with Subacromial Pain Syndrome (SPS) often present with a variety of contributing factors. It is possible that a subgroup exists within SPS that has primary impairments of scapular mobility and/or muscle strength. In an attempt to better identify scapular contributions in SPS, the Scapular Assistance Test (SAT) and Scapula Reposition Test (SRT) have been described. Additionally, thoracic spine thrust manipulation has been shown to be effective for shoulder pain. Problem Statement: It is currently unknown whether or not there are impairments in scapulothoracic muscle force generation or scapular mobility in individuals with SPS who have positive results on …

The Intracranial Aneurysm Gene Thsd1 Connects Endosome Dynamics To Nascent Focal Adhesion Assembly, Yan-Ning Rui, Zhen Yu, Xiaoqian Fang, Miriam R. Menezes, Julien Balzeau, Airu Niu, John P. Hagan, Dong H. Kim

School of Medicine Publications

Background/aims: We recently discovered that harmful variants in THSD1 (Thrombospondin type-1 domain-containing protein 1) likely cause intracranial aneurysm and subarachnoid hemorrhage in a subset of both familial and sporadic patients with supporting evidence from two vertebrate models. The current study seeks to elucidate how THSD1 and patient-identified variants function molecularly in focal adhesions.

Methods: Co-immunostaining and co-immunoprecipitation were performed to define THSD1 subcellular localization and interacting partners. Transient expression of patient-identified THSD1 protein variants and siRNA-mediated loss-of-function THSD1 were used to interrogate gene function in focal adhesion and cell attachment to collagen I in comparison to controls.

Results: THSD1 is …

Multiethnic Genome-Wide Meta-Analysis Of Ectopic Fat Depots Identifies Loci Associated With Adipocyte Development And Differentiation, Audrey Y. Chu, Xuan Deng, Virginia A. Fisher, Alexander Drong, Yang Zhang, Mary F. Feitosa, Ching-Ti Liu, Olivia Weeks, Audrey C. Choh, Qing Duan, Thomas D. Dyer

School of Medicine Publications

Variation in body fat distribution contributes to the metabolic sequelae of obesity. The genetic determinants of body fat distribution are poorly understood. The goal of this study was to gain new insights into the underlying genetics of body fat distribution by conducting sample-size weighted fixed-effects genome-wide association meta-analyses in up to 9,594 women and 8,738 men for six ectopic fat traits in European, African, Hispanic, and Chinese ancestry populations, with and without sex stratification. In total, 7 new loci were identified in association with ectopic fat traits (ATXN1, UBE2E2, EBF1, RREB1, GSDMB, GRAMD3 and ENSA; PATXN1 and UBE2E2 …

The Genetic Basis Of The Comorbidity Between Cannabis Use And Major Depression, Karen Hodgson, Laura Almasy, Emma E. M. Knowles, Jack W. Kent Jr., Joanne E. Curran, Thomas D. Dyer, Harald H. H. Goring, Rene L. Olvera, Mary D. Woolsey, Ravindranath Duggirala, Peter T. Fox, John Blangero, David C. Glahn

School of Medicine Publications

Background and aims—While the prevalence of major depression is elevated amongst cannabis users, the role of genetics in this pattern of comorbidity is not clear. This study aimed to estimate the heritability of cannabis use and major depression, quantify the genetic overlap between these two traits, and localize regions of the genome that segregate in families with cannabis use and major depression.

Design—Family-based univariate and bivariate genetic analysis.

Setting—San Antonio, Texas, USA

Participants—Genetics of Brain Structure and Function study (GOBS) participants: 1,284 Mexican-Americans from 75 large multi-generation families and an additional 57 genetically unrelated spouses.

Measurements …

Vitamin D Receptor Gene Bsm1 Polymorphism And Risk Of Breast Cancer, Sana Raza, Roshan Jahan, Anupam Dhasmana, Madan Lal Brahma Bhatt, Mohtashim Lohani, Jamal M. Arif

School of Medicine Publications

Breast cancer is a leading cause of death among women, around the world. It is a multifactorial disease involving genetic and environmental factors. Vitamin D is known to modulate biological processes like immune response, bone metabolism, cell growth regulation. The protective actions of vitamin D in cancer development are only sparsely understood, however, evidence shows that vitamin D participates in cell growth regulation, apoptosis and cell differentiation. It has also been implicated in the suppression of cancer cell invasion, angiogenesis and metastasis. The cellular effects of Vitamin D are mediated via Vitamin D receptor (VDR), which is a member of …

Interhospital Transfer Before Thrombectomy Is Associated With Delayed Treatment And Worse Outcome In The Stratis Registry (Systematic Evaluation Of Patients Treated With Neurothrombectomy Devices For Acute Ischemic Stroke), Michael T. Froehler, Jeffrey L. Saver, Osama O. Zaidat, Reza Jahan, Ameer E. Hassan

School of Medicine Publications

BACKGROUND: Endovascular treatment with mechanical thrombectomy (MT) is beneficial for patients with acute stroke suffering a large-vessel occlusion, although treatment efficacy is highly time-dependent. We hypothesized that interhospital transfer to endovascular-capable centers would result in treatment delays and worse clinical outcomes compared with direct presentation.

METHODS: STRATIS (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke) was a prospective, multicenter, observational, single-arm study of real-world MT for acute stroke because of anterior-circulation large-vessel occlusion performed at 55 sites over 2 years, including 1000 patients with severe stroke and treated within 8 hours. Patients underwent MT with or …

Medical Humanities: Using Medhum To Promote The Goal Of Professional Identity In Ume, Michael P.H. Stanley

MaineHealth Maine Medical Center

No abstract provided.

Determining Risk Of Falls In Community-Dwelling Older Adults: A Systematic Review And Meta-Analysis Using Posttest Probability, Michelle M. Lusardi, Stacy Fritz, Addie Middletown, Leslie Allison, Mariana Wingood, Emma Phillips, Michelle Criss, Sangita Verma, Jackie Osborne, Kevin Chui

All PTHMS Faculty Publications

BACKGROUND:

Falls and their consequences are significant concerns for older adults, caregivers, and health care providers. Identification of fall risk is crucial for appropriate referral to preventive interventions. Falls are multifactorial; no single measure is an accurate diagnostic tool. There is limited information on which history question, self-report measure, or performance-based measure, or combination of measures, best predicts future falls.

PURPOSE:

First, to evaluate the predictive ability of history questions, self-report measures, and performance-based measures for assessing fall risk of community-dwelling older adults by calculating and comparing posttest probability (PoTP) values for individual test/measures. Second, to evaluate usefulness of cumulative …

Green Jobs In Quebec: Definition And Assessment Of Potential Chemical And Biological Risks To Workers' Health, Erwan Cheneval, Marc-Antoine Busque, Claude Ostiguy, Jacques Lavoie, Robert Bourbonnais, France Labrèche, Joseph Zayed

Rapports de recherche scientifique

Les emplois générés par les efforts d’écologisation de l’économie sont en pleine croissance. Ces emplois, couramment appelés « emplois verts », étaient estimés en 2010 à plus de 155 000 au Québec et à 682 000 au Canada. Ces chiffres dépendent bien entendu des définitions données aux termes « écologie » et « environnement », mais donnent une idée de l’importance de ce secteur en croissance. Plusieurs nouvelles technologies se développent et il est impératif d’en apprécier les risques potentiels pour la santé des travailleurs.

L’objectif de cette recherche est de tracer le portrait québécois des emplois verts et d’apprécier …

Defining Physician Burnout, And Differentiating Between Burnout And Depression—I, Bianchi Renzo, Irvin Sam Schonfeld

Publications and Research

A redefinition of burnout as a depressive condition is called for so that the harmful effects of unresolvable job stress can be more accurately and comprehensively assessed. As research compellingly suggests, reducing the harmful effects of unresolvable job stress to the experience of burnout's dimensions of emotional exhaustion, depersonalization, and reduced personal accomplishment is mistaken in that it denies the depressive core of the syndrome referred to as “burnout.” Replacing the notion of burnout by the concept of job-induced depression would help us be more effective in the management of occupational adversity.