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Articles 13021 - 13050 of 14527
Full-Text Articles in Medicine and Health Sciences
Effects Of Cold Plasma On Surface, Thermal And Antimicrobial Release Properties Of Chitosan Film, Shashi Kishor Pankaj, Carmen Bueno-Ferrer, N.N. Misra, Luke O'Neill, Paula Bourke, P.J Cullen
Effects Of Cold Plasma On Surface, Thermal And Antimicrobial Release Properties Of Chitosan Film, Shashi Kishor Pankaj, Carmen Bueno-Ferrer, N.N. Misra, Luke O'Neill, Paula Bourke, P.J Cullen
Articles
This work aims to analyze the effects of cold atmospheric air plasma treatment of antimicrobial chitosan film with different levels of thymol. Optical characterization of the dielectric barrier discharge showed the generation of reactive nitrogen and oxygen species by the system. A significant increase in the surface roughness was observed after cold plasma treatment of the films. No significant difference was observed in the thermal profile of the plasma-treated films. A significant increase in the thymol diffusion coefficient was observed after the plasma treatment for all the active films.
Accuracy Of Full-Arch Scans Using Intraoral And Extraoral Scanners: An In Vitro Study Using A New Method Of Evaluation, Jonas Muallah, Christian Wesemann, Roxana Nowak, Jan Robben, James Mah, Peter Pospiech, Axel Bumann
Accuracy Of Full-Arch Scans Using Intraoral And Extraoral Scanners: An In Vitro Study Using A New Method Of Evaluation, Jonas Muallah, Christian Wesemann, Roxana Nowak, Jan Robben, James Mah, Peter Pospiech, Axel Bumann
Dental Medicine Faculty Research
The aim of this study was to compare the accuracy of six intraoral scanners as regards clinically relevant distances using a new method of evaluation. An additional objective was to compare intraoral scanners with the indirect digitization of model scanners. A resin master model was created by 3D printing and drilled in five places to reflect the following distances: intermolar width (IMW), intercanine width (ICW), and arch length (AL). To determine a gold standard, the distances were measured with a coordinate measuring instrument (Zeiss O-Inspect 422). The master model was scanned 37 times with the following intraoral scanners: Apollo DI …
Emotion Learning And Memory In Schizophrenia, M. N. Strong, D. N. Allen
Emotion Learning And Memory In Schizophrenia, M. N. Strong, D. N. Allen
McNair Poster Presentations
• Prior research indicates that processing of emotional information is particularly problematic for individuals with schizophrenia. • An important component of emotional processing is the accurate encoding and recall of emotionally valenced information. • The current study addresses this matter by investigating performance on a task assessing learning, recall, and recognition in patients with schizophrenia. • In this manner, recall of emotionally valenced information may be investigated
Insula Activation And What It May Tell Us About Food Motivation In Anorexia Nervosa: A Systematic Literature Review, Roxana K. Vazquez, Kristen Culbert
Insula Activation And What It May Tell Us About Food Motivation In Anorexia Nervosa: A Systematic Literature Review, Roxana K. Vazquez, Kristen Culbert
McNair Poster Presentations
• Anorexia nervosa (AN) is a severe psychiatric disorder characterized by recurrent refusal of caloric intake, resulting in emaciation. • Identifying whether neural networks that process food-related stimuli are affected in AN is important for understanding the biological basis of this illness, particularly severe food restriction. • The insular cortex is a key area that has been implicated; this brain region is associated with interoceptive awareness and gustation.
Differential Effects Of Child Maltreatment Type And Chronicity Variables On Ptsd Symptoms, Valerie Velasco, Amanda Howard, Christopher Kearney Ph.D
Differential Effects Of Child Maltreatment Type And Chronicity Variables On Ptsd Symptoms, Valerie Velasco, Amanda Howard, Christopher Kearney Ph.D
McNair Poster Presentations
Our interests:The current investigation studied the effect of maltreatment type and chronicity of trauma on posttraumatic stress disorder (PTSD) in a sample of school-aged children aged 6-18 years old. Why we’re interested:PTSD has been associated with serious developmental deficits in children that can lead to struggles with mental health and other adverse outcomes in adulthood (Dunn et al., 2017; Milot et al., 2010; Giaconia R. M. et al., 1995; Gwadz, Nish, Leonard, & Strauss, 2007). The current literature: • Children with exposure to child maltreatment traumas are at a significantly higher risk of developing PTSD than those with other trauma …
Mental Health Needs & Barriers: Assessment Of Latinos In Las Vegas, Vanessa L. Diaz, Janice C. Mcmurray Ph.D
Mental Health Needs & Barriers: Assessment Of Latinos In Las Vegas, Vanessa L. Diaz, Janice C. Mcmurray Ph.D
McNair Poster Presentations
- Research suggests that the prevalence of mental illness in Latinos is not necessarily uncommon and that economic concerns may be an important factor in determining the type of services Latinos are likely to seek (Kouyoumdjian, 2003).
- For Latinos, mental health disorders such as depression and anxiety have higher rates than the general population but the rate at which Latinos seek treatment is strikingly lower (Barrio, 2008).
- Observations regarding treatment engagement rates conclude that Latinos also have significantly higher probability of terminating treatments prematurely (Kouyoumdjian, 2003).
- Aim: to examine the mental health needs and barriers to treatment present in the Latino …
Pulmonary Hypertensive Crisis And Its Efficient Management. A Case Report And Literature Review, Karima Karam Khan, Fazal Hameed Khan
Pulmonary Hypertensive Crisis And Its Efficient Management. A Case Report And Literature Review, Karima Karam Khan, Fazal Hameed Khan
Department of Anaesthesia
Perioperative anaesthetic management of patients with pulmonary hypertensive crisis is complex and challenging because of limited window period and treatment options. This case report describes the successful management of a patient with severe valvular heart disease superimposed by severe pulmonary hypertension, who developed pulmonary hypertensive crisis soon after induction of general anaesthesia for cardiac surgery. Pulmonary hypertensive crisis is not a usual phenomenon in these patients, but if it occurs it can be fatal. Anticipatory care of the patient to prevent crisis is the mainstay of treatment, otherwise it adds additional morbidity to such patients. Fortunately our patient survived the …
Unlv Title Iii Aanapisi & Mcnair Scholars Institute Research Journal, Nir Herscovici, Joyce Hsu, Matthew Khumnark, Joy Lamug, Jeong Lim Lee, Kendall Lyons, Andrea Mandril, Niroshini Moodley, Eric Ng, Timothy Ogburn, Andrew A. Ortiz, Emily Khanh Pham, Nha Trang Vivian Sam, Devlynn Scarpati, Olivia Tsang, Termaine Antonio Turner Ii, Pang Kou Vang, Kanisha Wilson, Shannon Zayas, Claudia Chiang-Lopez, Victoria Copeland, Andrea Darby, Bridgett Giordmaina, Briceida Hernandez-Toledo, Mark Larubio, Ana Lesquives, Yessenia Madrigal, Summer Millwood, Angel Mims, Blaine Pennock, Katie Randolph, Amber K. Stephens, Sarah Werman, Eben-Ezer Arias-Garcia, Ernesto H. Bedoy, Royale Cannon, Irma De Santiago, Lorraine Louise K. Francisco, Imani A. Gayden, Jeffrey Gonzalez, Isaiah Shornell Henry, Ashley C. Lee, Marielle Leo, Elizabeth Ochoa, Bernajane Palisoc, Sean Tanzey, Howard Yanxon
Unlv Title Iii Aanapisi & Mcnair Scholars Institute Research Journal, Nir Herscovici, Joyce Hsu, Matthew Khumnark, Joy Lamug, Jeong Lim Lee, Kendall Lyons, Andrea Mandril, Niroshini Moodley, Eric Ng, Timothy Ogburn, Andrew A. Ortiz, Emily Khanh Pham, Nha Trang Vivian Sam, Devlynn Scarpati, Olivia Tsang, Termaine Antonio Turner Ii, Pang Kou Vang, Kanisha Wilson, Shannon Zayas, Claudia Chiang-Lopez, Victoria Copeland, Andrea Darby, Bridgett Giordmaina, Briceida Hernandez-Toledo, Mark Larubio, Ana Lesquives, Yessenia Madrigal, Summer Millwood, Angel Mims, Blaine Pennock, Katie Randolph, Amber K. Stephens, Sarah Werman, Eben-Ezer Arias-Garcia, Ernesto H. Bedoy, Royale Cannon, Irma De Santiago, Lorraine Louise K. Francisco, Imani A. Gayden, Jeffrey Gonzalez, Isaiah Shornell Henry, Ashley C. Lee, Marielle Leo, Elizabeth Ochoa, Bernajane Palisoc, Sean Tanzey, Howard Yanxon
McNair Journal
Journal articles based on research conducted by undergraduate students in the AANAPISI and McNair Scholars Programs
Table of Contents
About AANAPISI
Biography of Dr. Ronald E. McNair
Statements
Dr. Len Jessup, UNLV President
Dr. Juanita P. Fain, Vice President for Student Affairs
Dr. William W. Sullivan, Associate Vice President for Retention and Outreach
Mr. Keith Rogers, Deputy Executive Director of the Center for Academic Enrichment and Outreach
Title III AANAPISI and McNair Scholars Institute Staff
Ms. Terri Bernstein, Director for College Programs
Dr. Matthew Della Sala, Assistant Director for Undergraduate Research
Risk Factors For Recurrent Central Line-Associated Bloodstream Infections In Apediatric Intensive Care Unit, Rana İşgüder, İlker Devri̇m, Gökhan Ceylan, Ahu Kara, Gamze Gülfi̇dan, Hasan Ağin
Risk Factors For Recurrent Central Line-Associated Bloodstream Infections In Apediatric Intensive Care Unit, Rana İşgüder, İlker Devri̇m, Gökhan Ceylan, Ahu Kara, Gamze Gülfi̇dan, Hasan Ağin
Turkish Journal of Medical Sciences
Background/aim: It is recommended that a central venous catheter (CVC) be removed if central line-associated bloodstream infection (CLABSI) has been diagnosed. The objective of this retrospective study was to evaluate the risk factors for recurrent CLABSI in reinserted catheters in a pediatric intensive care unit. Materials and methods: Patients with recurrent and nonrecurrent CLABSI were compared in terms of the catheter exchange interval, the interval between negative blood culture and reinsertion of the CVC, and the pre-/reinsertion treatment duration. Results: Thirty-one patients with initial CLABSI had reinserted CVCs, and 12 (38.7%) of these patients were diagnosed with recurrent CLABSI. In …
Sex-Related Differences In The Efficacy Of Dexamethasone Pretreatmentfor Postoperative Analgesia In Patients Undergoing Laparoscopiccholecystectomy: A Randomized Controlled Study, Choel Lee, Jae-Yoon Chung, Myeongjong Lee
Sex-Related Differences In The Efficacy Of Dexamethasone Pretreatmentfor Postoperative Analgesia In Patients Undergoing Laparoscopiccholecystectomy: A Randomized Controlled Study, Choel Lee, Jae-Yoon Chung, Myeongjong Lee
Turkish Journal of Medical Sciences
Background/aim: Sex-related differences in response to pain have become a topic of increasing interest. However, sex-related differences in the efficacy of dexamethasone for postoperative analgesia have not been previously addressed. Materials and methods: The study included 196 men and 196 women, aged between 18 and 45 years, who were scheduled for laparoscopic cholecystectomy. The patients were randomly allocated into dexamethasone (M/F: 98/98) and control (normal saline; M/F: 98/98) groups. Patients in the study group received intravenous dexamethasone at 0.1 mg/kg (dexamethasone group) 1 h before induction of anesthesia. Patients in the control group received normal saline. Changes in cumulative morphine-containing, …
Obstructive Sleep Apnea Characteristics In Patients With Well-Controlled Acromegaly And Their Compliance With Positive Airway Pressure Therapy, Mehmet Sezai̇ Taşbakan, Özen Kaçmaz Başoğlu, Ilgin Yildirim Şi̇mşi̇r, Lütfi̇ye Füsun Saygili
Obstructive Sleep Apnea Characteristics In Patients With Well-Controlled Acromegaly And Their Compliance With Positive Airway Pressure Therapy, Mehmet Sezai̇ Taşbakan, Özen Kaçmaz Başoğlu, Ilgin Yildirim Şi̇mşi̇r, Lütfi̇ye Füsun Saygili
Turkish Journal of Medical Sciences
Background/aim: Acromegaly is often associated with obstructive sleep apnea syndrome (OSAS) with a frequency between 40% and 80%. The aim of the present study was to evaluate the clinical and polysomnographic characteristics of acromegaly patients with sleep apnea symptoms and to identify positive airway pressure (PAP) adherence in acromegaly patients with OSAS diagnosis.Materials and methods: Twenty-eight well-controlled acromegaly patients (17 males, mean age 48.7 $\pm$ 10.1 years) with sleep apnea symptoms were included in this prospective study. Demographic data, anthropometric measurements, and medical history were evaluated. Full-night in-laboratory polysomnography was performed.Results: Polysomnography results showed that 25 patients (89.3%) had OSAS …
Comparison Of Nutritional Risk Screening Tools For Predictingsarcopenia In Hospitalized Patients, Mehmet Yürüyen, Hakan Yavuzer, Serap Yavuzer, Mahi̇r Cengi̇z, Fi̇li̇z Demi̇rdağ, Zehra Kara, Suna Avci, Nurgül Özgür Yurttaş, Mehmet Sami̇ İslamoğlu, Eren İmre, Afrodi̇ta Zeynep Taşkin, Alper Döventaş, Ülev Deni̇z Erdi̇nçler
Comparison Of Nutritional Risk Screening Tools For Predictingsarcopenia In Hospitalized Patients, Mehmet Yürüyen, Hakan Yavuzer, Serap Yavuzer, Mahi̇r Cengi̇z, Fi̇li̇z Demi̇rdağ, Zehra Kara, Suna Avci, Nurgül Özgür Yurttaş, Mehmet Sami̇ İslamoğlu, Eren İmre, Afrodi̇ta Zeynep Taşkin, Alper Döventaş, Ülev Deni̇z Erdi̇nçler
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to assess the risk of malnutrition in hospitalized patients with three different tests and to compare these tests in terms of long hospitalization periods and sarcopenia. Materials and methods: Hospitalized patients in an internal medicine clinic were enrolled in this cross-sectional study. Patients were grouped as under 65 years (Group 1 = G1) and over 65 years old (Group 2 = G2). The nutritional status of the patients was evaluated with the Nutritional Risk Screening (NRS) 2002, Universal Malnutrition Screening Tool (MUST), Mini Nutritional Assessment Short Form (MNA-SF), and total Mini Nutritional Assessment …
How To Manage Pseudoangiomatous Stromal Hyperplasia: Our Clinical Experience, Emi̇ne Kurt, Sevi̇m Turanli, Fatma Markoç, Ali̇ Uğur Berberoğlu
How To Manage Pseudoangiomatous Stromal Hyperplasia: Our Clinical Experience, Emi̇ne Kurt, Sevi̇m Turanli, Fatma Markoç, Ali̇ Uğur Berberoğlu
Turkish Journal of Medical Sciences
Background/aim: Pseudoangiomatous stromal hyperplasia (PASH) is a rare and benign mesenchymal proliferative breast lesion. Our aim is to review the clinical and radiological features of PASH and define a standard approach for its diagnosis and management. Materials and methods: Clinical records of 35 consecutive patients with PASH were retrospectively reviewed between 2009 and 2015. Patients with clinically or radiologically detected mass and patients who underwent biopsy for other indications and were diagnosed incidentally were included in the study. Results: There were 34 female patients and one male patient with gynecomastia. Twenty-three patients had palpable masses, and 16 of them were …
Polymorphisms Of Cancer-Related Genes And Risk Of Multipleprimary Malignancies Involving Colorectal Cancer, Peiguo Cao, Li Yu, Anshan Wu, Jingjing Li, Ling Liu, Chunlan Liu, Jianda Zhou, Ke Cao, Chengxian Guo
Polymorphisms Of Cancer-Related Genes And Risk Of Multipleprimary Malignancies Involving Colorectal Cancer, Peiguo Cao, Li Yu, Anshan Wu, Jingjing Li, Ling Liu, Chunlan Liu, Jianda Zhou, Ke Cao, Chengxian Guo
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) of cancer-related genes and the risk of multiple primary malignancies involving colorectal cancer.Materials and methods: We collected tissue samples from 22 multiple primary cancer patients with primary colorectal cancer and performed genotyping assay for 116 SNP loci from 62 genes encoding peptides functioning in various signaling pathways using the DNA MassARRAY system. The chi-square test was used to compare the differences in base frequencies between patients and a control Chinese population from HapMap through the NCBI database.Results: No significant differences in frequencies were detected for 81 SNPs …
Dna Methylation Of The Prestin Gene And Outer Hair Cell Electromotileresponse Of The Cochlea In Salicylate Administration*, Erdoğan Bulut, Meti̇n Budak, Levent Öztürk, Mehmet Turgay Türkmen, Cem Uzun, Tammam Si̇pahi̇
Dna Methylation Of The Prestin Gene And Outer Hair Cell Electromotileresponse Of The Cochlea In Salicylate Administration*, Erdoğan Bulut, Meti̇n Budak, Levent Öztürk, Mehmet Turgay Türkmen, Cem Uzun, Tammam Si̇pahi̇
Turkish Journal of Medical Sciences
Background/aim: Activity of the prestin gene may have a role in the pathogenesis of salicylate-induced ototoxicity. We investigated DNA methylation for prestin gene exon 1 in salicylate-injected guinea pigs.Materials and methods: Fifteen guinea pigs (30 ears) underwent audiological evaluation including 1000 Hz probe-tone tympanometry and a distortion product otoacoustic emission (DPOAE) test. The animals were randomly divided into three groups. Groups 2 (8 ears) and 3 (14 ears) were injected with intramuscular saline and sodium salicylate (200 mg/kg), respectively twice daily for 2 weeks. Group 1 (8 ears) received no injection. DPOAE measurements were performed at baseline; after 1, 2, …
Plasma Urotensin Ii Levels In Primary Raynaud's Phenomenon And Systemic Sclerosis, Nevzat Gözel, Ahmet Karataş, Meltem Yardim, Mesude Seda Aydoğdu, Ramazan Ulu, Fati̇h Demi̇rcan, Faruk Kilinç, Burak Öz, Emi̇r Dönder, Süleyman Aydin, Süleyman Serdar Koca
Plasma Urotensin Ii Levels In Primary Raynaud's Phenomenon And Systemic Sclerosis, Nevzat Gözel, Ahmet Karataş, Meltem Yardim, Mesude Seda Aydoğdu, Ramazan Ulu, Fati̇h Demi̇rcan, Faruk Kilinç, Burak Öz, Emi̇r Dönder, Süleyman Aydin, Süleyman Serdar Koca
Turkish Journal of Medical Sciences
Background/aim: The pathogenesis of Raynaud's phenomenon (RP) has not yet been fully elucidated. RP is characterized by exaggerated cold-induced vasoconstriction. Urotensin II (UII) is a potent vasoconstrictor. The aim of the present study was to evaluate plasma UII levels in both primary RP and secondary RP associated with systemic sclerosis (SSc).Materials and methods: Fifteen patients with primary RP, 30 patients with RP secondary to SSc, and 30 healthy controls (HC) were included in the study. Raynaud condition scores (RCS) were determined in the primary RP and SSc groups. Modified Rodnan skin score (MRSS) was determined for the SSc patients. Plasma …
An Examination Of Healthcare-Associated Infections In Elderly Patients, Serap İskender, Gürdal Yilmaz, İftahar Köksal
An Examination Of Healthcare-Associated Infections In Elderly Patients, Serap İskender, Gürdal Yilmaz, İftahar Köksal
Turkish Journal of Medical Sciences
Background/aim: Healthcare-associated infections (HCAIs) are increasing due to the growing numbers of elderly people requiring long-term care and immunosuppressive therapies. The purpose of this study was to examine HCAIs occurring in elderly inpatients in our hospital.Materials and methods: This study prospectively investigated HCAIs developing in all patients hospitalized over a 1-year period. Diagnosis was based on Centers for Disease Control criteria. The results were subjected to statistical analysis between patients aged over and under 65.Results: A total of 24,692 patients were evaluated and 894 HCAIs were identified. Of these infections, 214 were seen in patients aged 65 or over. The …
Evaluation Of Ambulatory Arterial Stiffness Index In Hyperthyroidism, Özlem Turhan İyi̇di̇r, Mehmet Muhi̇tti̇n Yalçin, Alev Eroğlu Altinova, İsmai̇l Emre Arslan, Bahar Uncu Ulu, Ceyla Konca Değerteki̇n, Füsun Saadet Törüner
Evaluation Of Ambulatory Arterial Stiffness Index In Hyperthyroidism, Özlem Turhan İyi̇di̇r, Mehmet Muhi̇tti̇n Yalçin, Alev Eroğlu Altinova, İsmai̇l Emre Arslan, Bahar Uncu Ulu, Ceyla Konca Değerteki̇n, Füsun Saadet Törüner
Turkish Journal of Medical Sciences
Background/aim: Hyperthyroidism causes hemodynamic changes that are associated with adverse cardiovascular outcomes. Twenty-four-hour ambulatory blood pressure monitoring recordings provide us with some essential data: BP variability and ambulatory arterial stiffness index (AASI). In this study, we aimed to investigate AASI and short-term BP variability in both overt and subclinical hyperthyroidism and their relationship with thyroid hormones. Materials and methods: We enrolled 36 patients with subclinical hyperthyroidism, 23 patients with overt hyperthyroidism, and 25 healthy euthyroid controls. ABPM recording was performed for 24 h for all patients. Results: There were no statistically significant differences among the overt hyperthyroidism, subclinical hyperthyroidism, and …
Association Between Deep Neck Space Abscesses And Internal Carotid Artery Narrowing In Pediatric Patients, Betül Emi̇ne Deri̇nkuyu, Öznur Boyunağa, Meltem Polat, Çağri Damar, Anil Tapisiz, Ayşe Gül Alimli, Çi̇ğdem Öztunali, Soner Sertan Kara, Murat Uçar, Hasan Tezer
Association Between Deep Neck Space Abscesses And Internal Carotid Artery Narrowing In Pediatric Patients, Betül Emi̇ne Deri̇nkuyu, Öznur Boyunağa, Meltem Polat, Çağri Damar, Anil Tapisiz, Ayşe Gül Alimli, Çi̇ğdem Öztunali, Soner Sertan Kara, Murat Uçar, Hasan Tezer
Turkish Journal of Medical Sciences
Background/aim: Our aim was to interpret the effects of deep neck space abscesses on the adjacent carotid artery according to abscess location, as well as to determine narrowing by calculating the mean stenosis ratios.Materials and methods: Neck computed tomography scans and clinical data of 45 children with neck abscesses were evaluated retrospectively for abscess location and internal carotid artery narrowing. The lumen areas of the carotid arteries were measured from standard levels, and stenosis ratios were calculated with two different techniques. The mean stenosis ratios of each group according to abscess location were then compared with the control group.Results: Among …
Three-Dimensional Evaluation Of Pelvic Posture In Adolescents With And Without A History Of Low Back Pain, Seher Özyürek, Arzu Genç, Hayri̇ye Kul Karaali̇, Zeli̇ha Candan Algun
Three-Dimensional Evaluation Of Pelvic Posture In Adolescents With And Without A History Of Low Back Pain, Seher Özyürek, Arzu Genç, Hayri̇ye Kul Karaali̇, Zeli̇ha Candan Algun
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the three-dimensional (3D) profile of pelvic posture and postural displacements of the pelvis in adolescents with and without a history of low back pain (LBP). Materials and methods: Thirty-two adolescents participated in this study. Participants were asked if they had ever suffered LBP at some point in their lives. Participants were divided into two groups: with a history of LBP (LBP group) and without a history of LBP (control group). For 3D evaluation of pelvic posture, the PosturePrint system was used. Three digital photographs were obtained in an upright stance (anteroposterior, left-right lateral) and …
Synthesis Of Ag10 Analogs And Optimization Of Ttr Ligands For Half-Life Enhancement (Tlhe) Of Peptides, Raghavendra Jampala
Synthesis Of Ag10 Analogs And Optimization Of Ttr Ligands For Half-Life Enhancement (Tlhe) Of Peptides, Raghavendra Jampala
University of the Pacific Theses and Dissertations
The misassembly of soluble proteins into toxic aggregates, including amyloid fibrils, underlies a large number of human degenerative diseases. Cardiac amyloidosis, which is most commonly, caused by aggregation of Immunoglobulin (Ig) light chains or transthyretin (TTR) in the cardiac muscle, represent an important and often underdiagnosed cause of heart failure. TTR-mediated amyloid cardiomyopathies are chronic and progressive conditions that lead to arrhythmias, biventricular heart failure, and death. As no Food and Drug Administration-approved drugs are currently available for treatment of these diseases, the development of therapeutic agents that prevent TTR-mediated cardiotoxicity is desired. AG10 is a potent and selective kinetic …
Using The Medication Cabinet To Predict Fall Risk In Elderly Adults, Jessica Lopez
Using The Medication Cabinet To Predict Fall Risk In Elderly Adults, Jessica Lopez
University of the Pacific Theses and Dissertations
Background: In the United States, 30-60% of older adults fall each year; 10-20% of these falls result in injury, hospitalization, or even death. Better prevention of falls in this population may be facilitated by broader identification of risk factors. The use of statins has emerged as a potential risk factor, but the data provide conflicted results.
Purpose: To examine the relationship between statin use and falls among community-dwelling older adults.
Methods: We evaluated the patient registry of a Level 1 trauma center. All patients aged > 50 years who were admitted for falls in 2015 were included (n=615). Many of these …
The Influence Of The Supernumerary Clinical Nurse Educator Role On Advancing Graduate Nurses’ Quality Of Patient Care: A Mixed-Methods Study In A Private Western Australian Health Service, Tracey Coventry
Theses
Theoretical and anecdotal evidence suggests that the presence of the supernumerary clinical nurse educator (CNE) in the acute care hospital clinical environment will positively affect patient quality outcomes. However, the supernumerary role suffers from scrutiny in response to the financial constraints of healthcare organisations, and is questioned regarding sustainability. The lack of empirical research diminishes the CNE role and its benefit for patient quality of care. This research focuses on newly qualified graduate registered nurses (GRNs) employed in a graduate programme and supported by the CNE in the clinical environment in order to articulate the effect of the supernumerary CNE …
Exploring The Concept Of Receptivity To Bereavement Support: Implications For Palliative Care Services In Rural, Regional And Remote Western Australia, Pippa Blackburn
Exploring The Concept Of Receptivity To Bereavement Support: Implications For Palliative Care Services In Rural, Regional And Remote Western Australia, Pippa Blackburn
Theses
Background: Palliative care services are primary organisations that provide bereavement support in Australia and aim to mitigate potential adverse outcomes of grief and bereavement The success of bereavement services depends, in part, on how ‘receptive’ the bereaved are to receiving support. Although palliative care services provide support services for bereaved carers and families, there still remains a discord between what is delivered, what is needed and factors that deter or encourage a person’s receptiveness to support.
Purpose: The aim of this research was to examine utilisation of bereavement support through the ‘lens’ of receptivity. Bereavement and receptivity are complex multifactorial …
Bioimpedance Spectroscopy - Can It Be Used As A Tool For Monitoring Fluid Shifts In Burns?, Pippa Kenworthy
Bioimpedance Spectroscopy - Can It Be Used As A Tool For Monitoring Fluid Shifts In Burns?, Pippa Kenworthy
Theses
Large fluid shifts and oedema are features of burn injuries. Oedema hampers burn wound healing and is directly related to the size and depth of the burn. The degree of oedema in burns covers a broad spectrum: Minor burns cause localised or peripheral oedema, whilst major burns may result in a systemic inflammatory response which can be life threatening and necessitates formal fluid resuscitation. Acute burn fluid resuscitation is paramount in decreasing patient morbidity and mortality but can contribute to already large amounts of oedema. There is currently no single clinically applicable, non-invasive and accurate outcome measure to titrate fluid …
Assessment Of The Neuroprotective Potential Of Poly-Arginine Peptides In Stroke Models, Diego Milani
Assessment Of The Neuroprotective Potential Of Poly-Arginine Peptides In Stroke Models, Diego Milani
Theses
Currently, there is no available neuroprotective treatment for reducing acute brain injury following stroke. Recent studies have demonstrated that poly-arginine and arginine-rich peptides (e.g. R18; R = arginine residues) exhibit potent neuroprotective properties in both in vitro and in vivo stroke models, and therefore have the potential to be developed into a neuroprotective treatment for stroke.
Consequently, the aim of this thesis was to further assess the neuroprotective efficacy of several poly-arginine and arginine-rich peptides in permanent and transient middle cerebral artery occlusion (MCAO) stroke models in the rat.
The poly-arginine peptides R12, R15, R18 and the arginine-rich peptide protamine …
Public Health Briefs: The 15th Annual Michigan Epidemiology Conference
Public Health Briefs: The 15th Annual Michigan Epidemiology Conference
Michigan Journal of Public Health
This conference was designed to “foster communication and collaboration between epidemiologists in Michigan, and to promote epidemiology and public health through training, research and advocacy." Presenters at the 2105 Epidemiology Conference were invited to submit their abstracts for publication in the Michigan Journal of Public Health.
Abstracts include:
ROADMAP TO ELIMINATE HAIS
Dianne McCagg, APRN, B.C., MSN, MPRO
DISPARITIES IN HIV INFECTION AND CARE: FOCUS ON HISPANICS
Janae Wilson, M.S., Michigan Department of Health and Human Services
IS RISK OF CANNABIS DEPENDENCE LOWER FOR ‘CANNABIS ONLY’ USERS?
Karl Alcover, BA, Michigan State University
ESTIMATING FUTURE HEAT-RELATED MORTALITY DUE TO EXTREME …
Chemoselective And Stereoselective Exploration Of The Chemical Reactivity Space Of Castagnoli-Cushman-Derived Allylic Lactamoyl Esters: Application To The Synthesis Of Aza-Polycyclic Architectures, Brandon Joseph Mansker
Chemoselective And Stereoselective Exploration Of The Chemical Reactivity Space Of Castagnoli-Cushman-Derived Allylic Lactamoyl Esters: Application To The Synthesis Of Aza-Polycyclic Architectures, Brandon Joseph Mansker
All Master's Theses
The synthesis and evaluation of structure-activity relationships of saturated nitrogen heterocycles is the focal point of various pharmaceutical companies thanks to the high biological activity of previously isolated azacycles. Here, we describe an operationally simple and highly efficient approach to macrocyclic lactams bearing vicinal stereocenters and a challenging cycloalkyne motif. The outcomes are achieved through a novel [4 + 2] cycloaddition reaction between an N-iodoarylated-1,3-azadiene and cyclic anhydrides, followed by interception of the cycloadducts in cross-coupling manifolds (e.g., Sonogashira coupling) and concomitant lithiation-cyclization of the tethered alkyne. An unprecedented example of a hydroamino alkylation that is transition …
Effect Of A Sliding Scale Vitamin D Supplementation Protocol On 25(Oh)D Status In Elite Athletes With Spinal Cord Injury, Lauren Stark, Kelly Pritchett, Robert Pritchett, Elizabeth Broad
Effect Of A Sliding Scale Vitamin D Supplementation Protocol On 25(Oh)D Status In Elite Athletes With Spinal Cord Injury, Lauren Stark, Kelly Pritchett, Robert Pritchett, Elizabeth Broad
All Master's Theses
Recent studies suggest that a substantial proportion of elite athletes with SCI (spinal cord injury) have insufficient 25(OH)D status which may be associated with decreased muscle strength. This study: 1) examined the effects of a 16-week sliding scale Vitamin D supplementation protocol on 25(OH)D concentration and 2) determined whether subsequent 25(OH)D status impacts muscle performance in elite athletes with SCI. Thirty-four members of the US Olympic Committee Paralympic program, and the Canadian Wheelchair Sports Association from outdoor sports participated. Serum 25(OH)D concentrations, lifestyle and dietary factors were assessed during the Winter and Spring. Participants were assigned a 16-week sliding scale …
Just World Beliefs, Identity Development, And Social Justice Advocacy Of Counselor Trainees, Sara Rundlett
Just World Beliefs, Identity Development, And Social Justice Advocacy Of Counselor Trainees, Sara Rundlett
All Master's Theses
This was the first study exploring the relationship between the belief in a just world, identity development, and social justice advocacy (SJA). A mixed methods design was conducted using a nationwide sample of ninety-seven counselor-in-training participants. Hypotheses included positive correlation between identity development and SJA, negative correlation between belief in a just world and SJA, and negative correlation between belief in a just world and identity development. Results were not significant but provided implications for future research and counselor training programs.