Medicine and Health Sciences Commons^™

Effective Use Of Probiotic-Glyconutrient Combination As An Adjuvant To Antibiotic Therapy For Diarrhea In Rearing Dairy Calves, Gilberto Lopez Valencia, Octavio Zapata-Ramirez, Lilia Núñez-González, Victor Núñez-Benítez, Heriberto Landeros- López, Maria Lopez-Soto, Alberto Barreras Serrano, Victor Gonzalez-Vizcarra, Alfredo Estrada-Angulo, Richard Zinn, Alejandro Plascencia

Turkish Journal of Veterinary & Animal Sciences

Thirty Holstein calves presented with infectious diarrhea during the second week following birth were utilized to evaluate the effects of a standardized product containing a combination of probiotics, ß-glucans, and glyconutrients (GLY) in support of antibiotic therapy during the early rearing phase (day 7 to day 45 following birth). Treatments were 1) antibiotic therapy (trimethoprim and sulfas; ANTIB), and 2) ANTIB plus 5 g/calf per day GLY. Treatments did not affect diarrhea duration, averaging 16.7 days. However, GLY support decreased (P < 0.05) the mortality rate and increased (P < 0.05) live weight gain. Increased weight gain was attributable to enhanced (P < 0.05) consumption of calf starter. Supplemental GLY increased (P < 0.05) serum glucose and lowered (P < 0.05) serum urea nitrogen, nonesterified fatty acids, and cortisol concentration. We conclude that daily provision of 5 g of a standardized product containing probiotics, ß-glucans, and glyconutrients to diarrheic calves under antibiotic therapy will promote health and enhance early growth performance.

Ua37/6 Faculty Personal Papers L.Y. Lancaster, Wku Archives

WKU Archives Collection Inventories

Records regarding the nomination of Lennie Lancaster for the Kentucky Medical Association and Kentucky Academy of Family Physicians awards. The series is arranged in chronological order. A short biographical sketch by Dr. Jerry W. Martin, who made the nominations, is included. Dr. Lancaster's diplomas are in the collection, as well as an oral history interview conducted in 1973 which tells, among other things, of his work to establish Western's first campus bookstore in the summer of 1921. The collection also includes the KMA and KAFP awards, as well as several other certificates and awards.

New Mechanism Based Approaches For Treating Prostate Cancer, Rayna Rosati

Wayne State University Dissertations

Prostate cancer (PC) is generally dependent on the androgen signaling axis for tumor growth. PC is managed by androgen deprivation therapy (ADT). The tumors then frequently progress by restoring ADT-resistant AR signaling through mechanisms such as intratumoral androgen synthesis, overexpression of AR, expression of splice variants of AR and alteration in the balance of AR co-regulators. This stage of progression is termed castrate recurrent prostate cancer (CRPC). Moreover, ADT has many major undesirable acute and chronic side effects on various normal tissues. Therefore a more strategic therapy approach is one that would disrupt a functional arm of AR signaling critical …

Evaluation Of Program Satisfaction, Quality Of Life, Strength, And Fall Risk Of Community-Dwelling Older Adults Participating In A Community Exercise Program: Part 2, Marissa Adolphson, Roy Nelson, Jenna Wyffels

Physical Therapy Scholarly Projects

Background and Purpose: Bone Builders is an exercise program that incorporates both lower and upper extremities and is specifically designed for the older adult population. It was originally created for those that wanted to reduce their risk of osteoporosis, but currently there is no evidence that demonstrates these effects. However, exercises that are completed in the class are those that target causes of fall risk such as strengthening of hip abductors and balance activities. Participants have also reported that benefits of the class include improved balance, increased energy and mobility, and social support. Our study consisted of testing the …

Perceptions Of The Impact Of An Advanced Training Programme On The Management Skills Of Health Professionals In Gauteng, South Africa, Judith Mutyabule, F. Senkubuge, D. Cameron, V. Pillay, P. Petrucka

School of Nursing & Midwifery, East Africa

Background: South Africa’s health sector spans the private and the public sectors. Within the sectors, health managers take on strategic leadership roles without formal training in management or leadership – a trend more common in the public sector than the private sector. Health managers are selected based on their clinical skills rather than their leadership or management skills.

Objective: To compare self-rated competencies in management and leadership before and after training of the participants; to assess participants’ experience of the training programme; and to evaluate the management and leadership skills of the participants after training.

Methods: A cross-sectional, descriptive analytical …

Aluminum And Phthalates In Calcium Gluconate: Contribution From Glass And Plastic Packaging, Robert A. Yokel, Jason M. Unrine

Pharmaceutical Sciences Faculty Publications

Introduction: Aluminum contamination of parenteral nutrition solutions has been documented for three decades. It can result in elevated blood, bone, and whole body aluminum levels associated with neurotoxicity, reduced bone mass and mineral content, and perhaps hepatotoxicity. The primary aluminum source among parenteral nutrition components is glass-packaged calcium gluconate, in which aluminum concentration the past three decades has averaged~ 4000 [mu]g/L, compared to < 200 [mu]g/L in plastic container-packaged calcium gluconate. A concern about plastic packaging is leaching of plasticizers, including phthalates, which have the potential to cause endocrine (male reproductive system) disruption and neurotoxicity.

Methods: Aluminum was quantified in samples collected periodically over more than two years from three calcium gluconate sources used to prepare parenteral nutrition solutions; two packaged in glass (from France and the US) and one in plastic …

Developmental Toxicity Of Nicotine: A Transdisciplinary Synthesis And Implications For Emerging Tobacco Products, Lucinda J. Enland, Kjersti Aagaard, Michele Bloch, Kevin Conway, Kelly Cosgrove, Rachel Grana, Thomas J. Gould, Dorothy Hatsukami, Frances Jensen, Denise Kandel, Bruce Lanphear, Frances Leslie, James R. Pauly, Jenae Neiderhiser, Mark Rubinstein, Theodore A. Slotkin, Eliot Spindel, Laura Stroud, Lauren Wakschlag

Pharmaceutical Sciences Faculty Publications

While the health risks associated with adult cigarette smoking have been well described, effects of nicotine exposure during periods of developmental vulnerability are often overlooked. Using MEDLINE and PubMed literature searches, books, reports and expert opinion, a transdisciplinary group of scientists reviewed human and animal research on the health effects of exposure to nicotine during pregnancy and adolescence. A synthesis of this research supports that nicotine contributes critically to adverse effects of gestational tobacco exposure, including reduced pulmonary function, auditory processing defects, impaired infant cardiorespiratory function, and may contribute to cognitive and behavioral deficits in later life. Nicotine exposure during …

Opportunities And Challenges In Realizing Universal Access To Obstetric Ultrasound In Sub-Saharan Africa, Sikolia Wanyonyi, Charles Muriuki Mariara, Sudhir Vinayak, William Stones

Obstetrics and Gynaecology, East Africa

The potential benefits of obstetric ultrasound have yet to be fully realized in sub-Saharan Africa (SSA), despite the region bearing the greatest burden of poor perinatal outcomes. We reviewed the literature for challenges and opportunities of universal access to obstetric ultrasound and explored what is needed to make such access an integral component of maternity care in order to address the massive burden of perinatal morbidity and mortality in SSA. Original peer-reviewed literature was searched in various electronic databases using a ‘realist’ approach. While the available data were inconclusive, they identify many opportunities for potential future research on the subject …

Transitioning To Minimal Footwear: A Systematic Review Of Methods And Future Clinical Recommendations, Joe Warne, Allison H. Gruber

Articles

Recent interest in barefoot running has led to the development of minimalist running shoes that are popular in distance runners. A careful transition to these shoes has been suggested and examined in the literature. However, no guidelines based on systematic evidence have been presented.

Co-Colonisation With Aspergillus Fumigatus And Pseudomonas Aeruginosa Is Associated With Poorer Health In Cystic Fibrosis Patients: An Irish Registry Analysis, Emma Reece, Ricardo Segurado, Abaigeal Jackson, Siobhan Mcclean, Julie Renwick, Peter Greally

Articles

Pulmonary infection is the main cause of death in cystic fibrosis (CF). Aspergillus fumigatus (AF) and Pseudomonas aeruginosa (PA) are the most prevalent fungal and bacterial pathogens isolated from the CF airway, respectively. Our aim was to determine the effect of different colonisation profiles of AF and PA on the clinical status of patients with CF.

Hypoxia Reduces The Pathogenicity Of Pseudomonas Aeruginosa By Decreasing The Expression Of Multiple Virulence Factors, Bettina Schaible, Javier Rodriguez, Amaya Garcia, Alexander Von Kriegsheim, Siobhan Mcclean, Caitríona Hickey, Ciara E. Keogh, Eric Brown, Kirsten Schaffer, Alexis Broquet, Cormac T. Taylor

Articles

Our understanding of how the course of opportunistic bacterial infection is influenced by the microenvironment is limited. We demonstrate that the pathogenicity of Pseudomonas aeruginosa strains derived from acute clinical infections is higher than that of strains derived from chronic infections, where tissues are hypoxic. Exposure to hypoxia attenuated the pathogenicity of strains from acute (but not chronic) infections, implicating a role for hypoxia in regulating bacterial virulence. Mass spectrometric analysis of the secretome of P. aeruginosa derived from an acute infection revealed hypoxia-induced repression of multiple virulence factors independent of altered bacterial growth. Pseudomonas aeruginosa lacking the Pseudomonas prolyl-hydroxylase …

Sequential Burkholderia Cenocepacia Isolates From Siblings With Cystic Fibrosis Show Increased Lung Cell Attachment, Louise Cullen, Andrew O'Connor, Pavel Drevinek, Kirsten Schaffer, Siobhan Mcclean

Articles

No abstract available

The Running Performance Profile Of Elite Gaelic Football Match-Play, Shane Malone, Barry Solan, Kieran Collins

Articles

The current study examined (a) the match running performance of Gaelic football and (b) the decrement in match running performance with respect to position. Global positioning satellite system technologies (4-Hz; VX Sport) were used with 3 elite intercounty teams across 3 full seasons with 250 full game data sets collected. Game movements were classified according to game actions and distance covered across speed zone thresholds (total distance [TD], high-speed running distance [HSRD; ≥17 km·h], sprint distance [SD; ≥22 km·h]; accelerations [n]; peak speed [km·h]). The influence of running performance in each quarter on the subsequent quarter was analyzed across all …

Effect Of Game Design, Goal Type, And Player Numbers On The Physiological And Physical Demands Of Hurling-Specific Small-Sided Games, Shane Malone, Kieran Collins

Articles

The current study examined the effect that game design modification, goal type, and player numbers on the running performance and physiological demands of small-sided hurling games (SSG). Forty-eight hurling players (age, 25.5 ± 3.2 years; height, 178.9 ± 3.2 cm; body mass, 78.5 ± 4.5 kg) performed 4 types of SSG (possession [P], normal play [NP], regular goals [RG] and small goals [SG]) in 4-a-side, 5-a-side, and 6-a-side formats. Heart rate (Polar Electro Oy) and global positioning system technology (VX Sport, 4-Hz, Lower Hutt) were used to analyze the physical and physiological differences between SSG. Total distance (m), high-speed running …

The Influence Of Pitch Size On Running Performance And Physiological Responses During Hurling-Specific Small-Sided Games, Shane Malone, Kieran Collins

Articles

The current study examined how the impact of pitch dimensions influences physiological and running performance during 4-minute small-sided games (SSGs). Twenty-four (n = 24) hurling players were monitored with global positioning system and heart rate monitors during the in-season training period. Total distance (in meters), high-speed running distance (in meters) (≥17 km·h), very high-speed running distance (≥22 km·h) (in meters), total accelerations (n), acceleration distance (in meters), and peak and mean velocity (in kilometers per hour) were calculated. Additionally, SSGs rate of perceived exertion (RPESSG; AU), % maximum heart rate, and individualized training impulse (iTRIMP; AU) were collected. The current …

The Relationship Between Technical Performance Indicators And Running Performance In Elite Gaelic Football, Shane Mangan, Martin Ryan, Simon Devenney, Aidan Shovlin, Jason Mcgahan, Shane Malone, Cian O'Neill, Con Burns, Kieran Collins

Articles

The aim of the current study was to assess whether technical performance relates to positional running demands of elite Gaelic football players. Over a period of three years (2014–2016), four elite Gaelic football teams were monitored using GPS technologies. Four hundred and thirty-two individual player samples were collected from 52 competitive matches. Video analysis software was used to code technical performance indicators in all games. Pearson’s correlations were performed between all technical variables and total distance (m) and high-speed distance (≥17 km h−1). Total ball in play time had small to medium effects (r = .233 to .390, p …

A Contemporary Multi-Modal Mechanical Approach To Training Monitoring In Elite Professional Soccer, Adam Owen, Leo Djaoui, Matthew Newton, Shane Malone, Bruno Mendes

Articles

Objectives: Understanding movements and mechanical demands of elite soccer players during training and competitive stressors is important for the support provision of player performance. Continued appreciation to quantify and monitor training load (TL) is apparent, however reporting multi-modal approaches in-line with competitive match-play demands remain limited. The investigation aimed to highlight a multimodal training monitoring method and its relationship to match-play. Subjects: 29 elite European soccer players participated were assessed (26.7 ± 4.07 years, height 183.4 ± 5.87 cm, body mass 78.4 ± 8.03 kg, 57.55 ± 5.32 ml.kg⁻¹.min⁻¹ and body composition 54.12 ± 13.65 mm) with daily …

Gender Differences In Parents' Assessment Of Language Development, Michelle Lacroix

Honors Theses and Capstones

This study aims to determine if there is a statistically significant difference between genders in the reporting of their child’s communication abilities. Possible variances between men and women are important to consider because parent-based questionnaires are often used to help identify children who are in need and eligible for the services of a speech-language pathologist. Literature surrounding parental stereotypes and the impact of the parent in development, as well as stigma in relation to the need for speech therapy services is explored. A survey based off of the Ages and Stages Questionnaire, Third Edition was distributed to parents of children …

Characterizing Food Selectivity In Children With Autism, Samantha H. Wohlmacher

Honors Theses and Capstones

Food selectivity or “picky eating” affects a large percentage of children on the autism spectrum and as a result can have negative impacts on a child’s health and nutritional status (Cermak, Curtin, & Bandini, 2010). Few studies compare food selectivity in children on the autism spectrum to children with other developmental issues. Such a comparison may reveal how food selectivity presents itself uniquely in children on the autism spectrum. This study examined data from past health records collected from the Seacoast Childhood Development Center (SCDC). Thirty-eight children whose parents were concerned about their diets were taken from a larger sample …

Comparison Of Environmental Supports To A Healthy Lifestyle On The Unh Campus With Student Behaviors, Mary Hammar

Honors Theses and Capstones

Background: Environmental factors play a large role in shaping diet and lifestyle behaviors. Creating a college campus environment conducive to healthy dietary choices and physical activity may promote student health.

Objective: The objective of this study was to explore and describe the availability of environmental supports for a healthy lifestyle on the UNH campus and student behaviors.

Design: The Healthy Campus Environmental Audit (HCEA), a comprehensive tool developed by a USDA multi-state research team led by Syracuse University, was implemented to measure the availability of healthy options in dining establishments (n=12) and the adequacy of recreation facilities (n=3) and walking/biking …

Language Of Intervention In A Bilingual Child With Autism, Amelie Muzza

Open Access Theses & Dissertations

This study was conducted to address language of intervention for the rapidly-growing bilingual population of children with Autism Spectrum Disorder (ASD) in the United States. The purpose of this study was to determine whether a monolingual English or bilingual Spanish/English condition would yield a greater number of request types in a 3-year-old bilingual participant with autism. A single-subject, rapid alternating treatments design with baseline and a final maintenance phase was used to alternate between monolingual English and bilingual Spanish/English interventions. Results did not meet the criteria set for continuation of treatment in either condition; therefore, both monolingual and bilingual interventions …

Evaluation Of Pertussis Knowledge Within The Child Daycare Staff And Management In The El Paso, Texas, Diana Jaqueline Gomez

Open Access Theses & Dissertations

BACKGROUND: Child daycare centers have an enormous influence on the children's health, which is important to maintain daycare staff and management informed on how to prevent communicable diseases, such as pertussis. Bordetella pertussis (Bp), the causative agent of whooping cough, is a small gram-negative bacterium that infects the nasopharynx of humans, which are the only reservoir. Bp is a highly contagious respiratory disease, which continues to be a severe disease in infants. The disease affects all ages and is easily transmitted from person to person, through respiratory droplets. Even though there is a vaccine available for all ages there are …

An Overview Of Dissolved Organic Carbon In Groundwater And Implications For Drinking Water Safety, S. Regan, Paul Hynds, R. Flynn

Articles

Dissolved organic carbon (DOC) is composed of a diverse array of compounds, predominantly humic substances, and is a near ubiquitous component of natural groundwater, notwithstanding climatic extremes such as arid and hyper-arid settings. Despite being a frequently measured parameter of groundwater quality, the complexity of DOC composition and reaction behaviour means that links between concentration and human health risk are difficult to quantify and few examples are reported in the literature. Measured concentrations from natural/unpolluted groundwater are typically below 4 mg C/l, whilst concentrations above these levels generally indicate anthropogenic influences and/or contamination issues and can potentially compromise water safety. …

Evaluation Of Levels Of Antibiotic Resistance In Groundwater-Derived E. Coli Isolates In The Midwest Of Ireland And Elucidation Of Potential Predictors Of Resistance, Jean O'Dwyer, Paul Hynds, Matthieu Pot, Catherine Adley, Michael Ryan

Articles

Antibiotic-resistant (pathogenic and non-pathogenic) organisms and genes are now acknowledged as significant emerging aquatic contaminants with potentially adverse human and ecological health impacts, and thus require monitoring. This study is the first to investigate levels of resistance among Irish groundwater (private wells) samples; Escherichia coli isolates were examined against a panel of commonly prescribed human and veterinary therapeutic antibiotics, followed by determination of the causative factors of resistance. Overall, 42 confirmed E. coli isolates were recovered from a groundwater-sampling cohort. Resistance to the human panel of antibiotics was moderate; nine (21.4%) E. coli isolates demonstrated resistance to one or more …

Geospatial Drivers Of The Groundwater Δ18o Isoscape In A Temperate Maritime Climate (Republic Of Ireland), S. Regan, R. Goodhue, O. Naughton, Paul Hynds

Articles

In recent years, the concept of “isoscapes” has been used to describe spatiotemporal stable isotope distributions within natural environments including groundwater systems at multiple scales. This study presents an updated groundwater δ18O isoscape for the Republic of Ireland and describes the climatic and geological drivers influencing 18O composition. In all, 142 geographically and geologically representative groundwater installations were sampled and analysed, in addition to 35 samples from six nested boreholes. Geospatially, Irish groundwater exhibits high δ18O values in southern and western coastal regions, becoming progressively depleted inland before reaching lowest measured values along the eastern coast, equating to a national …

Differentiating Responses Of Lung Cancer Cell Lines To Doxorubicin Exposure: In Vitro Raman Micro Spectroscopy, Oxidative Stress And Bcl-2 Protein Expression, Zeineb Farhane, Franck Bonnier, Marcus A. Maher, Jane Bryant, Alan Casey, Hugh Byrne

Articles

The potential of Raman micro spectroscopy as an in vitro, non-invasive tool for clinical applications has been demonstrated in recent years, specifically for cancer research. To further illustrate its potential as a high content and label free technique, it is important to show its capability to elucidate drug mechanisms of action and cellular resistances. In this study, cytotoxicity assays were employed to establish the toxicity profiles for 24 hr exposure of lung cancer cell lines, A549 and Calu-1, to the commercially available drug, doxorubicin (DOX). Raman spectroscopy, coupled with Confocal Laser Scanning Microscopy and Flow Cytometry, was used to track …

Bayesian Exponential Random Graph Modelling Of Interhospital Patient Referral Networks, Alberto Caimo, Francesca Pallotti, Alessandro Lomi

Articles

Using original data that we have collected on referral relations between 110 hospitals serving a large regional community, we show how recently derived Bayesian exponential random graph models may be adopted to illuminate core empirical issues in research on relational coordination among healthcare organisations. We show how a rigorous Bayesian computation approach supports a fully probabilistic analytical framework that alleviates well-known problems in the estimation of model parameters of exponential random graph models. We also show how the main structural features of interhospital patient referral networks that prior studies have described can be reproduced with accuracy by specifying the system …

The Use Of Oral Appliances For Obstructive Sleep Apnea-Hypopnea Syndrome (Osahs ), You-Ning Gao, Jenny Zwei-Chieng Chang, Ming-Hsien Lan, Wen-Chung Chang, Yuan-Yi Tung

Taiwanese Journal of Orthodontics

The obstructive sleep apnea–hypopnea syndrome (OSAHS) is a common sleep-related breathing disorder characterized by repetitive obstructions of the upper airway during sleep. Nasal continuous positive airway pressure (CPAP) is the primary choice of treatment for OSAHS, but many patients are unable or unwilling to comply with the treatment. The modification of pharyngeal patency by oral appliances (OA) is an alternative treatment for OSAHS. This article provides a brief review and information of the oral appliance application in treating OSAHS.

Non-Surgical Treatment For A Patient With Angle Class Ii Division 2 Malocclusion With Severe Deep Bite: A Case Report, Yuan-Jung Wang, Jia-Iin Chang, Aaron Yu-Jen Wu, Ren-Jye Chen, Shiu-Shiung Lin, Te-Ju Wu

Taiwanese Journal of Orthodontics

This report describes a non-surgical orthodontic treatment for a 36-year-old male patient who had Class II division 2 malocclusion (Class II/2) with deep bite more than 100%, gingival recession, and periodontal abscess in the mandibular anterior region. Patient had history of trauma in region. The surgical intervention was once suggested but was refused by the patient. The compromised but acceptable final results were achieved by nonsurgical approach. The treatment plan included periodontal control, maxillary incisor intrusion and restoration of the collapsed occlusion. The total treatment duration was 43 months. The patient was satisfied with the treatment outcomes via interdisciplinary approach …

The Orthodontic Treatment Of Bilateral Impacted Maxillary Canines - A Case Report, Yu-Hsuan Chang-Chien, Li-Tyng Sun, Te-Ju Wu, Chia-Ling Tsai, Wei-Yung Hsu, Shiu-Shiung Lin

Taiwanese Journal of Orthodontics

The maxillary canine impaction is a specific topic in orthodontic treatment. Because of its important role in esthetics and occlusal function, preservation and alignment of the impacted canine would always be the priority in teenage orthodontics. In addition to the routine analysis of the space distribution for the impacted canines, orthodontists should also consider the growth potential to achieve proper treatment outcome. This case report presents the orthodontic treatment of a 14-year-old boy with bilateral maxillary canine impaction. With fixed orthodontic appliance, the bilaterally impacted canines were successfully aligned into maxillary dentition with good interdigitation. The prevalence, etiology and the …