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2017

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Articles 10501 - 10530 of 14524

Full-Text Articles in Medicine and Health Sciences

Effects Of Field Pea Supplementation On Digestibility And Rumen Volatile Fatty Acid Concentration Of Diets Containing High And Low Quality Forages, Hannah L. Greenwell, Jana L. Gramkow, Melissa L. Jolly-Breithaupt Breithaupt, Jim C. Macdonald, Karla Jenkins Jan 2017

Effects Of Field Pea Supplementation On Digestibility And Rumen Volatile Fatty Acid Concentration Of Diets Containing High And Low Quality Forages, Hannah L. Greenwell, Jana L. Gramkow, Melissa L. Jolly-Breithaupt Breithaupt, Jim C. Macdonald, Karla Jenkins

Nebraska Beef Cattle Reports

Five ruminally cannulated steers were used to evaluate the effects of supplementation (no supplement, field peas, or dry rolled corn; 0.43% BW) with high and low quality forages on diet digestibility and rumen volatile fatty acid concentrations. Th e inclusion of field peas increased dry matter intake and organic matter digestibility over dry rolled corn and unsupplemented steers. Propionate proportions were less for field peas and control treatments than dry rolled corn, while acetate proportions increased in field peas, and control treatments as compared to dry rolled corn. As a result, acetate to propionate ratio was reduced when dry rolled …


Effects Of Wintering System On Cow And Calf Performance In A Summer- Calving Intensive Production System, Shelby E. Gardine, Jason M. Warner, Curtis J. Bittner Bittner, Robert G. Bondurant, Karla Jenkins, Richard J. Rasby, Matt K. Luebbe, Galen E. Erickson, Terry J. Klopfenstein Jan 2017

Effects Of Wintering System On Cow And Calf Performance In A Summer- Calving Intensive Production System, Shelby E. Gardine, Jason M. Warner, Curtis J. Bittner Bittner, Robert G. Bondurant, Karla Jenkins, Richard J. Rasby, Matt K. Luebbe, Galen E. Erickson, Terry J. Klopfenstein

Nebraska Beef Cattle Reports

A study evaluated the effects of two wintering systems (cornstalk grazing and drylot feeding) on cow- calf performance in a summer- calving intensively managed cowherd at two locations. Grazing cow- calf pairs on cornstalks resulted in lower ending BW of cows and reduced ADG of calves when compared to drylot cow- calf pairs at weaning. A partial budget of incorporating winter cornstalk grazing into an intensive production system suggests that cows wintered on cornstalks were $136.85 more profitable when compared to cows wintered in the drylot.


Effects Of Modified Distillers Grains And Corn Ratios As Supplements In Diets Varying In Forage Quality On Performance Of Growing Beef Steers, Viviane B. Ferrari, Robert G. Bondurant, Galen E. Erickson Erickson, Terry J. Klopfenstein, Jim C. Macdonald Jan 2017

Effects Of Modified Distillers Grains And Corn Ratios As Supplements In Diets Varying In Forage Quality On Performance Of Growing Beef Steers, Viviane B. Ferrari, Robert G. Bondurant, Galen E. Erickson Erickson, Terry J. Klopfenstein, Jim C. Macdonald

Nebraska Beef Cattle Reports

Distillers grains (DG) have been intensively used for beef production, but prices relative to corn vary such that it may be beneficial to displace a portion of DG with corn in certain circumstances. Four ratios of supplemental energy (40% of diet DM) from modified distillers grains and corn (100:0, 80:20, 60:40, and 40:60) were supplemented in one of 3 forage diets (56% of diet DM) and evaluated for performance. Forages were high (brome hay + sorghum silage) or low quality. Low quality forages were corn residue baled through conventional rake and bale, or by disengaging the spreader on the combine …


Fatty Acid Composition Of Beef Fed Omnigen- Af At Receiving Or Finishing, Katherine I. Domenech, Michael D. Chao, Joe O. Buntyn Buntyn, Ty B. Schmidt, Chris Calkins Jan 2017

Fatty Acid Composition Of Beef Fed Omnigen- Af At Receiving Or Finishing, Katherine I. Domenech, Michael D. Chao, Joe O. Buntyn Buntyn, Ty B. Schmidt, Chris Calkins

Nebraska Beef Cattle Reports

Beef fatty acid profiles and superoxide dismutase activity were determined for cattle receiving OmniGen- AF supplementation (a patented nutritional supplement) at receiving (first 28 d at the feedlot) or throughout finishing (all 210 d of finishing) vs. a control group (non- supplemented). Th e most meaningful change in fatty acid composition from inclusion of OmniGen- AF was total poly- unsaturated fatty acid (PUFA) content where beef from the finishing group had more PUFA content in relation to the receiving group and was not different from the control group. Despite this increase in PUFA, cattle supplemented through finishing tended to have …


Effect Of Backgrounding System On Steer Performance And Carcass Characteristics, Jordan L. Cox, Kristin E. Hales, Kristen M. Ulmer Ulmer, Richard J. Rasby, Steven D. Shackleford, Chad Engle, John Rieckman, Harvey C. Freetly, Mary Drewnoski Jan 2017

Effect Of Backgrounding System On Steer Performance And Carcass Characteristics, Jordan L. Cox, Kristin E. Hales, Kristen M. Ulmer Ulmer, Richard J. Rasby, Steven D. Shackleford, Chad Engle, John Rieckman, Harvey C. Freetly, Mary Drewnoski

Nebraska Beef Cattle Reports

The impact of 3 backgrounding systems: grazing corn residue with distillers grains supplementation at 0.86% BW/d, grazing an oats-brassica forage, or feeding a grower ration in a drylot on finishing performance and carcass characteristics were evaluated. Backgrounding phase gains were greatest for steers fed a grower ration in the drylot (3.58 lb/d), intermediate for steers grazing oats-brassica forage and then fed the grower ration for short period (2.65 lb/d), and least for steers grazing corn residue while supplemented distillers grains and then fed the grower ration for short period (2.22 lb/d). These backgrounding treatment differences did not affect ADG during …


Shelf Life Of Ground Beef From Cattle Fed Distillers Grains Containing Different Amounts Of Oil, Faith D. Rasmussen, Chad G. Bower, Gary A. Sullivan Sullivan Jan 2017

Shelf Life Of Ground Beef From Cattle Fed Distillers Grains Containing Different Amounts Of Oil, Faith D. Rasmussen, Chad G. Bower, Gary A. Sullivan Sullivan

Nebraska Beef Cattle Reports

Beef shoulder clods were collected from steers fed one of four finishing diets: no distillers grains and three with distillers grains containing different amounts of oil. Raw ground beef patties were evaluated for changes in objective color, discoloration, and lipid oxidation during simulated retail display (7 days). Cooked beef links in refrigerated (18 days) and frozen storage (198 days) were analyzed for lipid oxidation throughout shelf life. Fatty acid profiles were evaluated in lean, subcutaneous fat, and ground composite samples. All distillers grain diets increased C18:2 and polyunsaturated fatty acids in beef. There were no dietary differences in lipid oxidation …


Rumen Undegradable Protein And Bambermycins Supplementation Of Calves Grazing Corn Residue, Cody A. Welchons, Robert G. Bondurant, F. Henry Hilscher Hilscher, Jim C. Macdonald, Galen E. Erickson Jan 2017

Rumen Undegradable Protein And Bambermycins Supplementation Of Calves Grazing Corn Residue, Cody A. Welchons, Robert G. Bondurant, F. Henry Hilscher Hilscher, Jim C. Macdonald, Galen E. Erickson

Nebraska Beef Cattle Reports

Steer calves grazing non- irrigated corn residue were supplemented with a corn residue and by- product pellet that contained either Soypass, soybean meal, or processed soybean meal at a rate of 4 lb / d. Additionally, a supplement was fed at 1 lb / d that provided 0 or 20 mg / steer daily of bambermycins (Gainpro®). There was no interaction between bambermycins inclusion and pellet type. Likewise, there was no effect of pellet type or bambermycins on ending BW or ADG. In order to maximize gain of calves grazing corn residue it is important to provide a supplement that …


Delineating Complex Forage Mixtures Using Plant-Wax Markers, Napoleón Vargas Jurado, Hannah C. Hamilton, Ronald M. Lewis Jan 2017

Delineating Complex Forage Mixtures Using Plant-Wax Markers, Napoleón Vargas Jurado, Hannah C. Hamilton, Ronald M. Lewis

Nebraska Beef Cattle Reports

Plant waxes provide a marker profile of individual plants that, when sufficiently distinct, can be used to estimate the diet composition of grazing cattle. They also may provide a tool for reliably predicting feed intake. The traditional method (nonnegative least squares) to use these markers to predict diet composition has limitations. A newer statistical approach (Bayesian linear unmixing) deemed more efficient was tested with simulation. Samples from 8 forage species in Nebraska were analyzed for their plant- wax marker contents. Those concentrations were used to simulate 1000 diets for 4 mixtures containing 2, 3, 5 or 8 plants. The efficiency …


Effect Of Corn Residue Grazing Or Baling On Subsequent Crop Yield And Nutrient Removal, Kristen M. Ulmer, Jordan L. Cox, Manbir K. Rakkar Rakkar, Robert G. Bondurant, Humberto Blanco-Canqui, Mary Drewnoski, Karla H. Jenkins, James C. Macdonald, Rick J. Rasby Jan 2017

Effect Of Corn Residue Grazing Or Baling On Subsequent Crop Yield And Nutrient Removal, Kristen M. Ulmer, Jordan L. Cox, Manbir K. Rakkar Rakkar, Robert G. Bondurant, Humberto Blanco-Canqui, Mary Drewnoski, Karla H. Jenkins, James C. Macdonald, Rick J. Rasby

Nebraska Beef Cattle Reports

A 2- year study evaluated the effect of corn residue baling or grazing on subsequent yields, as well as, nutrient removal by baling at five locations in Nebraska. Three treatments were applied to each field: baled, grazed, and control (no baling and no grazing). Grain and stover yields were measured by hand harvest at maturity. No differences were observed among treatments for corn yield with baled having yields of 234 bu grain / acre, grazed with 239 bu grain / acre and control with 223 bu grain / acre. Th ere was no difference in stover yield among treatments (8,326, …


Timed Insemination Vs. Modified Estrus Detection In Beef Heifers, Benjamin T. Tibbitts, Tonya L. Meyer, Dan J. Kelly Kelly, Richard N. Funston Jan 2017

Timed Insemination Vs. Modified Estrus Detection In Beef Heifers, Benjamin T. Tibbitts, Tonya L. Meyer, Dan J. Kelly Kelly, Richard N. Funston

Nebraska Beef Cattle Reports

Th e objective of this study was to compare a modified estrus detection and fixed time AI vs. no estrus detection and fixed time AI on subsequent pregnancy rates. Yearling heifers were estrus synchronized and AI at 72 ± 2 h after prostaglandin injection. In one group estrus was not detected and all heifers received gonadotropin releasing hormone at the fixed- time AI; in the other group estrus was detected at 58 ± 2 and 70 ± 2 h after prostaglandin and inseminated in the following order at 72 ± 2 h: heifers in estrus at 58 h, heifers in …


Growth And Reproductive Performance Of Yearling Beef Heifers Implanted With Revalor G In The Nebraska Sandhills, Benjamin T. Tibbitts, Hazy Rae Nielson, K. H. Ramsay Ramsay, Richard N. Funston Jan 2017

Growth And Reproductive Performance Of Yearling Beef Heifers Implanted With Revalor G In The Nebraska Sandhills, Benjamin T. Tibbitts, Hazy Rae Nielson, K. H. Ramsay Ramsay, Richard N. Funston

Nebraska Beef Cattle Reports

Th is study evaluated effects of a single stocker implant (Revalor G) on growth and reproductive performance of yearling beef heifers in the Nebraska Sandhills. Crossbred heifers, grazing native Sandhills range, were randomly assigned to either be implanted 82 ± 2 days prior to estrus synchronization, or not implanted, to determine the effects of growth implants on heifer performance. Heifers were bred via artificial insemination followed with clean- up bulls. Implanted heifers gained more and were heavier at the end of the trial, but had a reduced pregnancy rate than non- implanted heifers. Implanted heifers also had a lower pregnancy …


Impact Of Heifer Development System In Two Different Breeding Seasons, Shelby A. Springman, Hazy Rae Nielson, Jacqueline A. Musgrave Musgrave, John Nollette, Andy Applegarth, Richard N. Funston Jan 2017

Impact Of Heifer Development System In Two Different Breeding Seasons, Shelby A. Springman, Hazy Rae Nielson, Jacqueline A. Musgrave Musgrave, John Nollette, Andy Applegarth, Richard N. Funston

Nebraska Beef Cattle Reports

Replacement heifers from March and May calving herds were offered ad libitum meadow hay and 4 lb/d supplement or grazed meadow and offered 1 lb/d supplement from mid- January to mid- April. Heifers fed hay gained more during the treatment; however, heifers grazing meadow experienced compensatory gain, resulting in similar body weight at pregnancy diagnosis in both calving herds. Pregnancy rates were similar between treatment groups in March and May heifers. A reduced input winter management system is a viable option to maintain pregnancy rates in early and late summer breeding seasons.


Effects Of Distillers Grains Or Fiber On Enterohemorrhagic Escherichia Coli In Steers, Liesel G. Schneider, Curtis J. Bittner, Jordan E. Burhoop Burhoop, F. Henry Hilscher, Galen E. Erickson, Terry J. Klopfenstein, Rodney A. Moxley, David R. Smith Jan 2017

Effects Of Distillers Grains Or Fiber On Enterohemorrhagic Escherichia Coli In Steers, Liesel G. Schneider, Curtis J. Bittner, Jordan E. Burhoop Burhoop, F. Henry Hilscher, Galen E. Erickson, Terry J. Klopfenstein, Rodney A. Moxley, David R. Smith

Nebraska Beef Cattle Reports

Increased probability for fecal shedding and colonization by Escherichia coli O157:H7 has been observed in previous studies when steers are fed increased inclusions of distillers grains. A feeding study was conducted to determine if distillers grains or fiber from distillers grains in the finishing ration of feedlot steers affected fecal shedding prevalence of seven serogroups of enterohemorrhagic Escherichia coli (EHEC- 7). For EHEC O45 and EHEC O103, the greatest prevalence of shedding occurred when steers were fed increased distillers grains For all EHECs except for O111, fecal shedding prevalence was similar between the corn control and either of the corn …


Effect Of Long- Term Corn Residue Grazing On Soil Properties, Manbir K. Rakkar, Humberto Blanco, Mary E. Drewnoski Drewnoski, Jim C. Macdonald, Terry J. Klopfenstein Jan 2017

Effect Of Long- Term Corn Residue Grazing On Soil Properties, Manbir K. Rakkar, Humberto Blanco, Mary E. Drewnoski Drewnoski, Jim C. Macdonald, Terry J. Klopfenstein

Nebraska Beef Cattle Reports

An experiment was conducted to evaluate the effect of long- term (16 years) corn residue grazing with cattle on soil compaction, soil structure, soil organic matter, and nutrients. Three treatments: 1) fall grazing (November through January; 1.8 to 2.5 AUM/ac), 2) spring grazing (February to middle April; 2.3 to 3.1 AUM/ac), and 3) control (no grazing) under a no- till irrigated corn- soybean system in eastern Nebraska were studied. Crop yields were increased and soil bulk density and cone index (parameters of soil compaction), wet soil aggregate stability (parameter of soil structural quality), and organic matter content were not affected …


Effect Of Increasing Supplemental Rumen Undegradable Protein (Rup) On Performance Of Calves Fed A Silage Growing Diet, Colton R. Oney, F. Henry Hilscher, Robert G. Bondurant Bondurant, Andrea K. Watson, Galen E. Erickson, Terry J. Klopfenstein Jan 2017

Effect Of Increasing Supplemental Rumen Undegradable Protein (Rup) On Performance Of Calves Fed A Silage Growing Diet, Colton R. Oney, F. Henry Hilscher, Robert G. Bondurant Bondurant, Andrea K. Watson, Galen E. Erickson, Terry J. Klopfenstein

Nebraska Beef Cattle Reports

A growing study evaluated the effects of increasing supplemental rumen undegradable protein (RUP) on performance of calves fed an 85% corn silage diet. Five levels of supplementation were evaluated with 12 individually fed steers per level of supplement. Supplement levels consisted of 0, 3.25, 6.5, 9.75 and 13% supplemental RUP (% of diet DM) fed as a blend of 60% Soypass and 40% Empyreal. Increasing supplemental RUP in the diet increased ending body weight and average daily gain linearly, and decreased F:G linearly while DMI remained constant among treatments. As cattle grew from 600 to 730 lb, F:G was improved …


2017 Nebraska Beef Cattle Report (Complete) Jan 2017

2017 Nebraska Beef Cattle Report (Complete)

Nebraska Beef Cattle Reports

Contents

Cow/Calf: Effect of Heifer Development System on Reproduction and Subsequent Gain as a Pregnant Heifer • Impact of Heifer Development System in Two Breeding Seasons • Timed Insemination vs. Modifi ed Estrus Detection in Beef Heifers • Growth and Reproductive Performance of Yearling Beef Heifers Implanted with Revalor G in the Nebraska Sandhills • Development of Terminal and Maternal Economic Selection Indices in Beefmaster Cattle • Effects of Wintering System on Cow and Calf Performance in a Summer- Calving Intensive Production System • Methods to Increase Productivity of Spring Calving Production Systems in the Nebraska Sandhills

Growing: Effect of …


Complications Of In-Patient Cerebral Angiography: Comparison Between Patients With And Without Sub Arachnoid Haemorrhage, Yaseen Rauf, Usman Tariq Siddiqui, Gohar Javed Jan 2017

Complications Of In-Patient Cerebral Angiography: Comparison Between Patients With And Without Sub Arachnoid Haemorrhage, Yaseen Rauf, Usman Tariq Siddiqui, Gohar Javed

Section of Neurosurgery

Objective: To compare complications of cerebral angiography among patients with and without subarachnoid haemorrhage.
Methods: This retrospective study was conducted at the Aga Khan University Hospital, Karachi, and comprised records of patients undergoing inpatient therapeutic and diagnostic cerebral angiographies from 2001 to 2010. The patients were divided into subarachnoid and non-subarachnoid haemorrhage groups. During the study period no modifications were made to the operational protocol and all patients were subjected to the same procedure and prophylactic care.
Results: Of the 93 patients, 42(45.2%) were women and 51(54.8%) were men. The overall mean age was 45.27±16.15 years (range: 4-80 years). The …


Attitude Towards Gender Roles And Violence Against Women And Girls (Vawg): Baseline Findings From An Rct Of 1752 Youths In Pakistan, Tazeen S. Ali, Rozina Karmaliani, Judith Mcfarlane, Hussain M. A. Khuwaja, Yasmeen Somani, Esnat D. Chirwa, Rachel Jewkes Jan 2017

Attitude Towards Gender Roles And Violence Against Women And Girls (Vawg): Baseline Findings From An Rct Of 1752 Youths In Pakistan, Tazeen S. Ali, Rozina Karmaliani, Judith Mcfarlane, Hussain M. A. Khuwaja, Yasmeen Somani, Esnat D. Chirwa, Rachel Jewkes

School of Nursing & Midwifery

Background: Violence against women is driven by gender norms that normalize and justify gender inequality and violence. Gender norms are substantially shaped during adolescence. Programs offered through schools offer an opportunity to influence gender attitudes toward gender equity if we understand these to be partly shaped by peers and the school environment.
Objective
: We present an analysis of the baseline research conducted for a randomized controlled trial with 1752 grade 6 boys and girls and their attitudes toward gender roles, VAWG, and associated factors.
Methods
: We used baseline data from a cluster randomised control study. Interviews were …


Cultural Practices Of Rearing Preterm Infants: A Qualitative Study In A Tertiary Care Hospital, Karachi, Pakistan, Salima Sulaiman Gulamani, Ambreen Tharani, Sharifa Bashir Lalani, Kiran Shaikh Jan 2017

Cultural Practices Of Rearing Preterm Infants: A Qualitative Study In A Tertiary Care Hospital, Karachi, Pakistan, Salima Sulaiman Gulamani, Ambreen Tharani, Sharifa Bashir Lalani, Kiran Shaikh

School of Nursing & Midwifery

The research work explores the cultural practices of feeding and hygiene of preterm infants in the Pakistani context. A Qualitative descriptive-exploratory design has been used. Purposive sampling was utilized to recruit 17 mothers, who met inclusion criteria from a largest government tertiary care hospital in Karachi, Pakistan. The semi-structured interview was used to collect the data, which lasted for approximately 45-60 minutes. Thematic analysis was conducted to analyze the key findings of the study. Welcoming newborn with 'honey' and herbal remedies were reported as a common ritual among mothers. Findings revealed differences in the time period of initial bath given …


Association Of Awareness About Hepatitis C Infection With Patterns Of Health Seeking Behavior Among Hepatitis C Patients In Karachi, Pakistan, Shahina S. Pirani, Saleema Allana, Tazeen S. Ali, Faisal Wasim Ismail Jan 2017

Association Of Awareness About Hepatitis C Infection With Patterns Of Health Seeking Behavior Among Hepatitis C Patients In Karachi, Pakistan, Shahina S. Pirani, Saleema Allana, Tazeen S. Ali, Faisal Wasim Ismail

School of Nursing & Midwifery

Background: Hepatitis C infection is one of the significant causes of morbidity and mortality throughout the world. In Pakistan, hepatitis C infection rate is 4.8%, which is the second highest prevalence rate among all developing countries. This study aimed to identify the association between awareness about hepatitis C infection and pattern of health seeking behavior among patients living with hepatitis C in Karachi, Pakistan.
Methods: A descriptive, cross-sectional study was conducted among 250 hepatitis C patients who were recruited from the Aga Khan University Hospital and the Civil Hospital Karachi, Pakistan between March and May 2013. Data were …


Exploring The Impact Of Gender Inequities On The Promotion Of Cardiovascular Health Of Women In Pakistan, Rubina Barolia, Alexander M. Clark, Gina M. Higginbottom Jan 2017

Exploring The Impact Of Gender Inequities On The Promotion Of Cardiovascular Health Of Women In Pakistan, Rubina Barolia, Alexander M. Clark, Gina M. Higginbottom

School of Nursing & Midwifery

Cardiovascular disease exerts an enormous burden on women's health. The intake of a healthy diet may reduce this burden. However, social norms and economic constraints are often factors that restrain women from paying attention to their diet. Underpinned by critical realism, this study explores how gender/sex influences decision-making regarding food consumption among women of low socioeconomic status (SES). The study was carried out at two cardiac facilities in Karachi, Pakistan, on 24 participants (male and female from different ethnic backgrounds), who had received health education. Using an interpretive descriptive approach, the study identified major barriers to a healthy diet: proscribed …


Studies On Antihyperlipidemic And Endothelium Modulatory Activities Of Polyherbal Formulation (Pol4) And Its Ingredients In High Fat Diet-Fed Rats, Abdul Malik, Malik H Mehmood, Muhammad S Akhtar, Anwar Gilani Jan 2017

Studies On Antihyperlipidemic And Endothelium Modulatory Activities Of Polyherbal Formulation (Pol4) And Its Ingredients In High Fat Diet-Fed Rats, Abdul Malik, Malik H Mehmood, Muhammad S Akhtar, Anwar Gilani

Department of Biological & Biomedical Sciences

A compound herbal formulation (POL4) is used traditionally in interior parts (Distt. Badin) of Sindh, Pakistan, for the treatment of metabolic disorders like diabetes and hyperlipidemia. This study is aimed to determine the effectiveness of POL4 and its ingredients in hyperlipidemia and associated endothelial dysfunction and hypertension. POL4 is composed of equal proportion of Nigella sativa, Cichorium intybus, Trigonella foenum graecum and Gymnema sylvestre mixed in powdered form. Chronic (6 to 7 weeks) administration of POL4 and its ingredients mixed in diet caused a notable attenuation in total cholesterol, low density lipoprotein cholesterol, triglycerides, atherogenic index, C-reactive protein and glucose, …


Dialectics Of Imagination And Experimentation: Basic Science Research In Developing Countries, Hr Ahmad, Na Khan Jan 2017

Dialectics Of Imagination And Experimentation: Basic Science Research In Developing Countries, Hr Ahmad, Na Khan

Department of Biological & Biomedical Sciences

No abstract provided.


Engineered Peptides For Applications In Cancer-Targeted Drug Delivery And Tumor Detection, R. Soudy, N. Byeon, Y. Raghuwanshi, S. Ahmed, A. Lavasanifar, Kamaljit Kaur Jan 2017

Engineered Peptides For Applications In Cancer-Targeted Drug Delivery And Tumor Detection, R. Soudy, N. Byeon, Y. Raghuwanshi, S. Ahmed, A. Lavasanifar, Kamaljit Kaur

Pharmacy Faculty Articles and Research

Cancer-targeting peptides as ligands for targeted delivery of anticancer drugs or drug carriers have the potential to significantly enhance the selectivity and the therapeutic benefit of current chemotherapeutic agents. Identification of tumor-specific biomarkers like integrins, aminopeptidase N, and epidermal growth factor receptor as well as the popularity of phage display techniques along with synthetic combinatorial methods used for peptide design and structure optimization have fueled the advancement and application of peptide ligands for targeted drug delivery and tumor detection in cancer treatment, detection and guided therapy. Although considerable preclinical data have shown remarkable success in the use of tumor targeting …


Burden Of Illness And Pharmacoeconomic Evaluation Of Lumacaftor/Ivacaftor In Cystic Fibrosis, Pratyusha Vadagam Jan 2017

Burden Of Illness And Pharmacoeconomic Evaluation Of Lumacaftor/Ivacaftor In Cystic Fibrosis, Pratyusha Vadagam

Electronic Theses and Dissertations

Objectives: (1) To estimate the burden of illness in cystic fibrosis (CF) using 2010-2014 Medical Expenditure Panel Survey (MEPS) data, and (2) to conduct a pharmacoeconomic evaluation of lumacaftor/ivacaftor in the treatment of CF.

Methods: The study was conducted in two parts. Part 1 involved a retrospective analysis using individuals in MEPS database with an International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) diagnosis code of 277.00 for a principal diagnosis of CF. Dependent variables were cumulative and out-of-pocket (OOP) expenditures and independent variables included patient demographics and clinical characteristics. Unweighted and weighted estimates of expenditure in CF group, …


Retention And Attrition In Bariatric Surgery Research: A Qualitative Study, William F. Gourash Jan 2017

Retention And Attrition In Bariatric Surgery Research: A Qualitative Study, William F. Gourash

Electronic Theses and Dissertations

Problem: Longitudinal bariatric surgical research studies often lack information on retention and attrition of study participants and the strategies utilized to optimize these. The potential for attrition bias with adverse effects on validity, reliability, and generalizability increases over time. The many factors potentially affecting retention and attrition in research, have been under studied.

Purpose: The purpose was to explore factors affecting research participation of bariatric surgical patients who are subjects in the Longitudinal Assessment of Bariatric Surgery (LABS) study. The research questions explored research participants’ perceptions, motivations, and attitudes concerning participation in the study, specifically participation in annual in-person visits …


Comparing Cmaq Forecasts With A Neural Network Forecast Model For Pm2.5 In New York, Samuel D. Lightstone, Fred Moshary, Barry Gross Jan 2017

Comparing Cmaq Forecasts With A Neural Network Forecast Model For Pm2.5 In New York, Samuel D. Lightstone, Fred Moshary, Barry Gross

Publications and Research

Human health is strongly affected by the concentration of fine particulate matter (PM2.5). The need to forecast unhealthy conditions has driven the development of Chemical Transport Models such as Community Multi-Scale Air Quality (CMAQ). These models attempt to simulate the complex dynamics of chemical transport by combined meteorology, emission inventories (EI’s), and gas/particle chemistry and dynamics. Ultimately, the goal is to establish useful forecasts that could provide vulnerable members of the population with warnings. In the simplest utilization, any forecast should focus on next day pollution levels, and should be provided by the end of the business day (5 p.m. …


Consumers, Clergy, And Clinicians In Collaboration: Ongoing Implementation And Evaluation Of A Mental Wellness Program, Glen Milstein, Dennis Middel, Adriana Espinosa Jan 2017

Consumers, Clergy, And Clinicians In Collaboration: Ongoing Implementation And Evaluation Of A Mental Wellness Program, Glen Milstein, Dennis Middel, Adriana Espinosa

Publications and Research

As a foundation of most cultures, with roots in persons’ early development, religion can be a source of hope as well as denigration. Some religious institutions have made attempts to help persons with mental health problems, and some mental health professionals have sought to engage religion resources. These programs have rarely been sustained. In 2008, the Mental Health Center of Denver (MHCD) developed a program to assess the utility of religion resources within mental health care. In response to positive feedback, MHCD appointed a director of Faith and Spiritual Wellness who facilitates community outreach to faith communities and spiritual integration …


Catastrophes And Complicated Intraoperative Events During Robotic Lung Resection., Brian E Louie Jan 2017

Catastrophes And Complicated Intraoperative Events During Robotic Lung Resection., Brian E Louie

Articles, Abstracts, and Reports

Intraoperative complications and catastrophes are an accepted and perhaps inevitable aspect of all surgeries. Anatomic pulmonary resection puts in close proximity the tracheal-bronchial tree, pulmonary vasculature, heart and great vessels within the small volume area of the chest. Fortunately, major complications and catastrophes are uncommon regardless of surgical approach. Pulmonary arterial injury is the most frequently reported. Most injuries necessitate a thoracotomy for definitive management though novel techniques are emerging for minimally invasive management. This section focuses on intraoperative pulmonary artery and vein injuries, major airway injuries and transections, injuries to major abdominal organs and effects of carbon dioxide insufflation …


The Feasibility Of Implementing The Ichom Standard Set For Hip And Knee Osteoarthritis: A Mixed-Methods Evaluation In Public And Private Hospital Settings., Ilana N Ackerman, Bernarda Cavka, Jacob Lippa, Andrew Bucknill Jan 2017

The Feasibility Of Implementing The Ichom Standard Set For Hip And Knee Osteoarthritis: A Mixed-Methods Evaluation In Public And Private Hospital Settings., Ilana N Ackerman, Bernarda Cavka, Jacob Lippa, Andrew Bucknill

Articles, Abstracts, and Reports

Background: There is growing international momentum for standardising patient outcome assessment and using patient-reported outcome measures (PROMs) to capture outcomes that matter to patients. The International Consortium for Health Outcomes Measurement (ICHOM) Standard Sets were developed to capture the outcomes of care for costly conditions including osteoarthritis. This study evaluated the feasibility of implementing the ICHOM Standard Set for Hip and Knee Osteoarthritis in 'real world' public and private hospital settings.

Methods: A mixed-methods design was used to capture comprehensive data on patient outcomes, implementation costs, and the implementation experiences of patients, clinicians and administrative staff. The ICHOM Standard Set …