Medicine and Health Sciences Commons^™

Some Permanent Hearing Loss Is Missed When "Switched Ear" Passes Are Used To Determine Screening Results, Beverly G. Lim, Maria Perez-Abalo, Jillian Gerstenberger, Shauna Morales Flowers

Journal of Early Hearing Detection and Intervention

A common practice in Universal Newborn Hearing Screen (UNHS) programs is rolling up non-simultaneous passing results in each ear (SW_EAR) from repeat automated screens into a bilateral pass. This study aims to provide evidence-based criteria for best practices regarding SW_EAR screens. From January 2010 to May 2013, infants with SW_EARs results were prospectively monitored by MEDNAX-Pediatrix’s nationwide UNHS program, which combine inpatient/outpatient screens utilizing automated auditory brainstem response (AABR). The tracked audiologic evaluations of 16,129 refer infants (2,334 due to SW_EAR) out of the total infant population screened (2,492,314) were analyzed retrospectively. A high proportion of hearing loss (354/2334, 15%) …

Measuring Nurses' Knowledge And Understanding Of Universal Newborn Hearing Screenings, Caitlyn Roberts, Alisha L. Jones

Journal of Early Hearing Detection and Intervention

The present study was conducted to investigate the knowledge and understanding of Universal Newborn Hearing Screening (UNHS) in nursing professionals. A group of 15 adult, licensed nurses with varied professional experience participated in the study. Participants completed both objective and subjective measurements to evaluate their current knowledge of training procedures. A free online UNHS training program offered through the National Center for Hearing Assessment and Management (NCHAM) served as both the objective measure and training module. Participants completed pre- and post-surveys as the subjective measure of their UNHS training. Results of these surveys were compared across the participants to determine …

Parental Satisfaction And Objective Test Measurements Associated With Post-Partum Versus Nursery Newborn Hearing Screening, Jennifer E. Bentley, Wenyang Mao, Wendy Timpson, Jane Stewart

Journal of Early Hearing Detection and Intervention

Beth Israel Deaconess Medical Center (BIDMC; Boston, MA) initiated a change to the newborn hearing screening program in 2013 to encourage increased parental presence at the time of screening and support a more family centered hospital environment. Newborn hearing screening program technicians were encouraged to conduct all hearing screens in the parent’s post-partum rooms instead of in the nursery. To measure the effect of this change on the families and screening measures, satisfaction surveys and retrospective data was collected over a 2 year period and compared. Newborn hearing screening program technicians and mother-baby nursing staff were surveyed to determine influence …

Scheduling Hearing Appointments Prior To Hospital Discharge Improves Follow-Up After Failed Newborn Screening, Tri Tran, Lili Schindelar, Terri Ibieta, Jeanette Webb, Wendy Jumonville, Melinda Peat, Susan Berry

Journal of Early Hearing Detection and Intervention

The study aimed to identify if there was a relationship between a follow-up hearing appointment scheduled prior to hospital discharge (hospital scheduled appointment) and follow-up status, including loss to follow-up or loss to documentation (LTF/LTD); early follow-up initiation; and early completion of audiological diagnosis. The study included 4,597 children who were born between January 2015 and June 2016 in Louisiana birthing hospitals and failed newborn hearing screening (NHS) prior to hospital discharge. Of the study population, 56.1% of children were scheduled for a follow-up hearing appointment prior to hospital discharge. Among children without a hospital scheduled appointment, the rate of …

Are Audiologists Directly Referring Children With Hearing Loss To Early Intervention?, Natalie Loyola, Bridget Shanahan, Cailin Shanahan, Kosuke Kawai, Derek J. Stiles

Journal of Early Hearing Detection and Intervention

This article describes the ways that pediatric audiologists are directing infants into Early Intervention, and the related barriers and facilitators. Over one hundred pediatric audiologists responded to an online survey including questions on how audiologists provide direct and indirect referrals to Early Intervention for those infants that are diagnosed with hearing loss. Most respondents agreed that audiologists are the best person to provide this referral, but many audiologists did not make the direct referral. Barriers to direct referral included time constraints and resistance from parents. Opportunities identified to improve referral included online referral systems and national guidelines for what qualifies …

Effectiveness Of Dexmedetomidine For Sedation In Auditory Brainstem Response Testing, Laura Sherry, Eric Levey, Carolyn Gillen, Joseph P. Pillion

Journal of Early Hearing Detection and Intervention

Sedation is widely used for auditory brainstem response (ABR) testing for infants or young children who are unable to sleep or remain adequately quiet for testing. Because chloral hydrate is no longer readily available, dexmedetomidine has been proposed as an alternative medicinal agent to achieve moderate levels of sedation without risk of respiratory depression. The purpose of the study was to assess the effectiveness of dexmedetomidine in terms of the completeness of the audiologic data obtained in achieving moderate levels of sedation for auditory brainstem response testing. A retrospective chart review was conducted on ninety-nine patients at Kennedy Krieger Institute. …

Using Data To Improve Services For Infants With Hearing Loss: Linking Newborn Hearing Screening Records With Early Intervention Records, Maria Gonzalez, Lori Iarossi, Yan Wu, Ying Huang, Kirsten Siegenthaler

Journal of Early Hearing Detection and Intervention

The purpose of this study was to match records of infants with permanent hearing loss from the New York Early Hearing Detection and Intervention Information System (NYEHDI-IS) to records of infants with permanent hearing loss receiving early intervention services from the New York State Early Intervention Program (NYSEIP) to identify areas in the state where hearing screening, diagnostic evaluations and referrals to the NYSEIP were not being made or documented in a timely manner. Data from 2014-2016 NYEHDI-IS and NYEIS information systems were matched using The Link King. There were 274 infants documented in NYEIS Information System as receiving early …

Decreasing Delirium Through Music (Ddm) In Critically Ill, Mechanically Ventilated Patients In The Intensive Care Unit: Protocol For A Randomized Controlled Trial, Annie Heiderscheit, Sikandar H. Khan, Sophia Wang, Amanda Harrawood, Stephanie Martinez, Linda Chlan, Anthony J. Perkins, Wanzhu Tu, Malaz Boustani, Babar Khan

Faculty Authored Articles

Background

Delirium is a highly prevalent and morbid syndrome in intensive care units (ICUs). Changing the stressful environment within the ICU via music may be an effective and a scalable way to reduce the burden of delirium.

Methods/design

The Decreasing Delirium through Music (DDM) study is a three-arm, single-blind, randomized controlled feasibility trial.

Sixty patients admitted to the ICU with respiratory failure requiring mechanical ventilation will be randomized to one of three arms (20 participants per arm): (1) personalized music, (2) non-personalized relaxing music, or (3) attention-control. Music preferences will be obtained from all enrolled participants or their family caregivers. …

Sex Trafficking: A Toolbox For Apn's, Nissa Berbawy

Graduate Research Projects

Abstract

Objective: As the fastest growing crime in the world (Walker-Rodriguez, & Hill, 2011) and with sex slaves found in all 50 states (Grace et al, 2014), finding a solution to the problem of sex slavery is critical. One study showed 63.3% of sex slave survivors were treated in the emergency department while enslaved, revealing an opportunity for healthcare providers to intervene (The Emergency Nurses Association, 2015). The purpose of this review of literature is to provide evidence based resources to better equip APN’s to identify, intervene, and refer sex slaves for successful rehabilitative services. Methods: Databases searched were …

Best And Worst Nutrition Plan, Lawren Kariuki

Student Scholarship

In this project I chose two fast food restaurants which consisted of 3 meals from each and calculated their nutritional value to compare and contrast the differences.

Assessing The Effect Of Aromatherapy On Fundamental Nursing Student Cognitive Test Anxiety: A Mixed Methods Approach., Regina Lankford

Graduate Research Projects

Abstract

Background and Objectives: Will aromatherapy make a difference on student cognitive test anxiety among fundamental nursing students? The purpose of this literature review was to assess the effect of aromatherapy as a teaching strategy to decrease test anxiety and improve student cognition and academic performance.

Methods: A pilot research study was conducted on eight fundamental nursing students, using a mixed method approach. Phenomenology looked at student perceptions while quantitative used a correlation randomized approach. For every test a pre and posttest anxiety questionnaire and pulse rate was collected. The students were exposed to aromatherapy treatment alternating with no …

Linkage, Whole Genome Sequence, And Biological Data Implicate Variants In Rab10 In Alzheimer's Disease Resilience., Perry G Ridge, Celeste M Karch, Simon Hsu, Ivan Arano, Craig C Teerlink, Mark T W Ebbert, Josue D Gonzalez Murcia, James M Farnham, Anna R Damato, Mariet Allen, Xue Wang, Oscar Harari, Victoria M Fernandez, Rita Guerreiro, Jose Bras, John Hardy, Ronald Munger, Maria Norton, Celeste Sassi, Andrew Singleton, Steven G Younkin, Dennis W Dickson, Todd E Golde, Nathan D Price, Nilüfer Ertekin-Taner, Carlos Cruchaga, Alison M Goate, Christopher Corcoran, Joann Tschanz, Lisa A Cannon-Albright, John S K Kauwe

Articles, Abstracts, and Reports

BACKGROUND: While age and the APOE ε4 allele are major risk factors for Alzheimer's disease (AD), a small percentage of individuals with these risk factors exhibit AD resilience by living well beyond 75 years of age without any clinical symptoms of cognitive decline.

METHODS: We used over 200 "AD resilient" individuals and an innovative, pedigree-based approach to identify genetic variants that segregate with AD resilience. First, we performed linkage analyses in pedigrees with resilient individuals and a statistical excess of AD deaths. Second, we used whole genome sequences to identify candidate SNPs in significant linkage regions. Third, we replicated SNPs …

Binge Alcohol Exposure Transiently Changes The Endocannabinoid System: A Potential Target To Prevent Alcohol-Induced Neurodegeneration, Daniel J. Liput, James R. Pauly, Audra L. Stinchcomb, Kimberly Nixon

Pharmaceutical Sciences Faculty Publications

Excessive alcohol consumption leads to neurodegeneration, which contributes to cognitive decline that is associated with alcohol use disorders (AUDs). The endocannabinoid system has been implicated in the development of AUDs, but little is known about how the neurotoxic effects of alcohol impact the endocannabinoid system. Therefore, the current study investigated the effects of neurotoxic, binge-like alcohol exposure on components of the endocannabinoid system and related N-acylethanolamines (NAEs), and then evaluated the efficacy of fatty acid amide hydrolase (FAAH) inhibition on attenuating alcohol-induced neurodegeneration. Male rats were administered alcohol according to a binge model, which resulted in a transient decrease in …

Taking Control: Reorganization Of The Host Cytoskeleton By Chlamydia., Jordan Wesolowski, Fabienne Paumet

Department of Microbiology and Immunology Faculty Papers

Both actin and microtubules are major cytoskeletal elements in eukaryotic cells that participate in many cellular processes, including cell division and motility, vesicle and organelle movement, and the maintenance of cell shape. Inside its host cell, the human pathogen Chlamydia trachomatis manipulates the cytoskeleton to promote its survival and enhance its pathogenicity. In particular, Chlamydia induces the drastic rearrangement of both actin and microtubules, which is vital for its entry, inclusion structure and development, and host cell exit. As significant progress in Chlamydia genetics has greatly enhanced our understanding of how this pathogen co-opts the host cytoskeleton, we will discuss …

Genetic Signatures For Helicobacter Pylori Strains Of West African Origin, Kennady K. Bullock, Carrie L. Shaffer, Andrew W. Brooks, Ousman Secka, Mark H. Forsyth, Mark S. Mcclain, Timothy L. Cover

Veterinary Science Faculty Publications

Helicobacter pylori is a genetically diverse bacterial species that colonizes the stomach in about half of the human population. Most persons colonized by H. pylori remain asymptomatic, but the presence of this organism is a risk factor for gastric cancer. Multiple populations and subpopulations of H. pylori with distinct geographic distributions are recognized. Genetic differences among these populations might be a factor underlying geographic variation in gastric cancer incidence. Relatively little is known about the genomic features of African H. pylori strains compared to other populations of strains. In this study, we first analyzed the genomes of …

Psychometric Evaluation Of The Professional Moral Courage (Pmc) Scale In A Nurse Executive Population, Joanne Connor

Theses & Dissertations

Statement of the Problem The nurse executive must navigate a health care environment with competing priorities and conflicting pressures. The rapid changes and economic demands in healthcare present challenges and ethical dilemmas for the nurse executive. The nurse executive is to be professionally and morally responsible to meet the expectation of the role in accordance with ethical standards of the nursing profession. Professional moral courage is the attribute necessary to influence decisions and actions when advocating for the nurse and the patient, while benefiting the organization. Subsequently, the ability to accurately assess this characteristic is an imperative. The Professional Moral …

Differences In Mental Health Education Across Baby Boomers, Generation X, And Millennials, Ashlyn M. Avera

Honors College Theses

There is no denying that mental illness has gained a strong prevalence in the United States. According to the National Alliance on Mental Illness, approximately one in five adults in the United States experiences a mental illness in any given year. Although mental health stigmas have played a role in the past, it does not mean they must continue to play the same role in the future. Research is now looking toward ways to decrease mental health stigma through increasing mental health knowledge. This study examines the starting point for which a society becomes literate in mental health. Using a …

Linkage, Whole Genome Sequence, And Biological Data Implicate Variants In Rab10 In Alzheimer’S Disease Resilience, Perry G. Ridge, Celeste M. Karch, Simon Hsu, Ivan Arano, Craig C. Teerlink, Mark T. W. Ebbert, Josue D. Gonzalez Murcia, James M. Farnham, Anna R. Damato, Mariet Allen, Xue Wang, Oscar Harari, Victoria M. Fernandez, Rita Guerreiro, Jose Bras, John Hardy, Ronald G. Munger, Maria Norton, Celeste Sassi, Andrew Singleton, Steven G. Younkin, Dennis W. Dickson, Todd E. Golde, Nathan D. Price, Nilüfer Ertekin-Taner, Carlos Cruchaga, Alison M. Goate, Chris D. Corcoran, Joann T. Tschanz, Lisa A. Cannon-Albright, John S. Kauwe, Alzheimer’S Disease Neuroimaging Initative

Nutrition, Dietetics, and Food Sciences Faculty Publications

Background

While age and the APOE ε4 allele are major risk factors for Alzheimer’s disease (AD), a small percentage of individuals with these risk factors exhibit AD resilience by living well beyond 75 years of age without any clinical symptoms of cognitive decline.

Methods

We used over 200 “AD resilient” individuals and an innovative, pedigree-based approach to identify genetic variants that segregate with AD resilience. First, we performed linkage analyses in pedigrees with resilient individuals and a statistical excess of AD deaths. Second, we used whole genome sequences to identify candidate SNPs in significant linkage regions. Third, we replicated SNPs …

Optimization Of The Hockey Fans In Training (Hockey Fit) Weight Loss And Healthy Lifestyle Program For Male Hockey Fans, Wendy Blunt, Dawn P. Gill, Shannon Sibbald, Brendan Riggin, Roseanne Pulford, Ryan Scott, Karen Danylchuk, Cindy M. Gray, Sally Wyke, Christopher Bunn, Robert Petrella

Lifestyle Research Team

BACKGROUND:

The health outcomes of men continue to be poorer than women globally. Challenges in addressing this problem include difficulties engaging men in weight loss programs as they tend to view these programs as contrary to the masculine narrative of independence and self-reliance. Researchers have been turning towards sports fans to engage men in health promotion programs as sports fans are typically male, and tend to have poor health habits.

METHODS:

Developed from the highly successful gender-sensitized Football Fans in Training program, Hockey Fans in Training (Hockey FIT) recruited 80 male hockey fans of the London Knights and Sarnia Sting …

Honors Seminar In Civic Engagement And Social And Behavioral Science: Citizen Science: Self-Experiments Hpr 392, Julia Lovett

Library Impact Statements

No abstract provided.

Psoas Abscess Masquerading As A Prosthetic Hip Infection: A Case Report, Muhammad Atif, Azeem Tariq Malik, Shahryar Noordin

Section of Orthopaedic Surgery

Introduction: Psoas abscess is an unusual condition and is defined as a collection of pus in the iliopsoas compartment. Due to the unique anatomy of psoas muscle it forms a conduit for spread of infection from upper part of body to hip joint in neglected cases.
Case Presentation: A 67year old lady presented with left groin pain for three weeks. She underwent an uncemented unipolar hemiarthoplasty eight years back. Currently, she developed fever and was unable to do any active left hip range of motion. Passive motion of the left hip was restricted to 30° flexion, no internal rotation, 5° …

Transcriptome-Wide Identification Of The Rna-Binding Landscape Of The Chromatin-Associated Protein Parp1 Reveals Functions In Rna Biogenesis, Manana Melikishvili, Julia H. Chariker, Eric C. Rouchka, Yvonne N. Fondufe-Mittendorf

Molecular and Cellular Biochemistry Faculty Publications

Recent studies implicate Poly (ADP-ribose) polymerase 1 (PARP1) in alternative splicing regulation, and PARP1 may be an RNA-binding protein. However, detailed knowledge of RNA targets and the RNA-binding region for PARP1 are unknown. Here we report the first global study of PARP1–RNA interactions using PAR–CLIP in HeLa cells. We identified a largely overlapping set of 22 142 PARP1–RNA-binding peaks mapping to mRNAs, with 20 484 sites located in intronic regions. PARP1 preferentially bound RNA containing GC-rich sequences. Using a Bayesian model, we determined positional effects of PARP1 on regulated exon-skipping events: PARP1 binding upstream and downstream of the skipped exons …

Cancer Treatment And Monitoring Methods Using Ox40 Agonists, Brendan Curti, Magdalena Kovacsovics-Bankowski, Ed Walker, Josh Walker, Andy Weinberg

Technology Transfer - Patents

OX40 is a potent immune stimulating target . Provided herein are methods for the treatment of cancer patients using ( 3X40 agonists methods to predict clinical outcome of the treatment by correlation of the treatment and an increase in OX40 - induced T cell proliferation .

Educational Strategies For Preventing And Managing Coronary Artery Disease (Cad), Anna M. Mills

The University Honors Program

Coronary artery disease (CAD) is a leading cause of death in the United States and many older people suffer from this disease (Luisi et al., 2015). It is vital that nurses understand the importance of education, good nursing care, and support in improving patient outcomes. Nurses care for patients with heart disease every day and it is important that nurses have a good understanding of the disease process, how to effectively educate patients, and how to care for them in hospital and community settings. The purpose of this project is to (1) perform a comprehensive literature review regarding prevention, education, …

The Effectiveness Of Non-Stimulants For The Treatment Of Attention Deficit Hyperactivity Disorder In The Pediatric Population, Rebecca Gonzalez

Nursing Capstones

No abstract provided.

Language Proficiency And Academic Success Of Bilingual Hispanic Nursing Students, Cristina Dominguez

Nursing Theses and Dissertations

The United States (U.S.) experienced recent growth in its minority population. This requires an increase of culturally diverse healthcare providers. English as a second language (ESL) students face challenges such as overcoming their inability to write, comprehend, and communicate in a language different from their native tongue. The study explored the role of language proficiency on academic success among bilingual nursing students on the U.S. and Mexico border.

Cummins Language Proficiency Model guided the study, which aimed to answer whether the dimensions of language proficiency or language acculturation predicted self - assessed language proficiency and academic success. The relationship between …

Challenges In Characterizing The Environmental Fate And Effects Of Carbon Nanotubes And Inorganic Nanomaterials In Aquatic Systems, Peter Laux, Christian Riebeling, Andy M. Booth, Joseph D. Brain, Josephine Brunner, Cristina Cerrillo, Otto Creutzenberg, Irina Estrela-Lopis, Thomas Gebel, Gunnar Johanson, Harald Jungnickel, Heiko Kock, Jutta Tentschert, Ahmed Tlili, Andreas Schäffer, Adriënne J. A. M. Sips, Robert A. Yokel, Andreas Luch

Pharmaceutical Sciences Faculty Publications

The current lack of commonly used protocols for dispersion, characterization, and aquatic toxicity testing of nanomaterials (NMs) has resulted in inconsistent results, which make meaningful comparisons difficult. The need for standardized sample preparation procedures that allow the reproducible generation of relevant test conditions remains a key challenge for studies of the environmental fate and aquatic toxicity of NMs. Together with the further development of optimized and cost-effective analytical techniques for physicochemical characterization that depend on reproducible sample preparation, such methods have the potential to overcome the current uncertainties with regard to NM dispersion properties, effective dose, and particle dissolution. In …

12-05-2017 Hsc Committee Agenda, Patrice Martin

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Recurrent Renal Cancer In Birt-Hogg-Dube Syndrome: A Case Report, Hammad Ather, Nida Zahid

Department of Surgery Docs

Introduction: Birt-Hogg-Dube syndrome (BHDS) is a rare autosomal dominant disease. It is caused by constitutional mutations in the FLCN gene. Since BHDS is a rare syndrome therefore it is unknown to many physicians. However, it is important to identify this rare syndrome at early stages because incidence of renal cancer in BHD patients is very high and its detection at early stages can prevent its metastasis. Hence, we want to present a case of BHDS and draw the attention of the treating physician to this rare inherited disorder and discuss its appropriate diagnosis and management.CASE PRESENTATION: We present a case …

Site-Specific Selection Reveals Selective Constraints And Functionality Of Tumor Somatic Mtdna Mutations., Deyang Li, Xiaohong Du, Xu Guo, Lei Zhan, Xin Li, Chun Yin, Cheng Chen, Mingkun Li, Bingshan Li, Hushan Yang, Jinliang Xing

Department of Medical Oncology Faculty Papers

BACKGROUND: Previous studies have indicated that tumor mitochondrial DNA (mtDNA) mutations are primarily shaped by relaxed negative selection, which is contradictory to the critical roles of mtDNA mutations in tumorigenesis. Therefore, we hypothesized that site-specific selection may influence tumor mtDNA mutations.

METHODS: To test our hypothesis, we developed the largest collection of tumor mtDNA mutations to date and evaluated how natural selection shaped mtDNA mutation patterns.

RESULTS: Our data demonstrated that both positive and negative selections acted on specific positions or functional units of tumor mtDNAs, although the landscape of these mutations was consistent with the relaxation of negative selection. …