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2015

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Articles 9691 - 9720 of 11981

Full-Text Articles in Medicine and Health Sciences

Effect Of Keratinocyte Growth Factor On Growth And Transdifferentiationof Primary Alveolar Epithelial Type Ii Cells, Xiuxiang Liu, Zhichun Feng, Chunmei Tian, Xiangyong Kong, Yumei Wu, Changjun Lv Jan 2015

Effect Of Keratinocyte Growth Factor On Growth And Transdifferentiationof Primary Alveolar Epithelial Type Ii Cells, Xiuxiang Liu, Zhichun Feng, Chunmei Tian, Xiangyong Kong, Yumei Wu, Changjun Lv

Turkish Journal of Medical Sciences

Background/aim: To investigate the effects of keratinocyte growth factor (KGF) on the growth and transdifferentiation of primary alveolar epithelial type II cells (AECIIs). Materials and methods: The number of primary AECIIs, their viability, and cell cycle and apoptosis were studied under KGF treatment using a hemocytometer, trypan blue exclusion, and flow cytometry, respectively. Positive expressions of surfactant protein C (SP-C), aquaporin 5 (AQP5), and thyroid transcription factor 1(TTF-1) were examined with indirect immunofluorescence; mRNA levels of SP-C, AQP5, and TTF-1 were determined by polymerase chain reaction. Results: In response to KGF treatment, cell numbers were significantly increased, more cells were …

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Protective Effect Of \Beta-Glucan On Acute Lung Injury Induced Bylipopolysaccharide In Rats, Meryem Iraz, Mustafa Iraz, Mukaddes Eşrefoğlu, Mehmet Şeri̇f Aydin Jan 2015

Protective Effect Of \Beta-Glucan On Acute Lung Injury Induced Bylipopolysaccharide In Rats, Meryem Iraz, Mustafa Iraz, Mukaddes Eşrefoğlu, Mehmet Şeri̇f Aydin

Turkish Journal of Medical Sciences

Background/aim: Lipopolysaccharide (LPS)-induced endotoxemia can cause serious organ damage such as acute lung injury and death by triggering the secretion of proinflammatory cytokines and acute-phase reactants. The goal of this study was to evaluate the effects of \beta-glucan on inflammatory mediator levels and histopathological changes in LPS-induced endotoxemia. Materials and methods: Forty-seven male Wistar albino rats were randomly allocated into four groups as follows: control group, LPS group (10 mg/kg LPS), LPS + \beta-glucan group (100 mg/kg \beta-glucan before LPS administration), and \beta-glucan group. Twelve hours after LPS administration, lung and serum samples were collected. Concentrations of IL-6, IL-8, C-reactive …

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Vitamin E Modulates Lung Oxidative Stress, Serum Copper, Zinc, And Iron Levels In Rats With Pulmonary Contusion, Mehmet Sirmali, Okan Solak, Tali̇p Çevi̇k, Rana Sirmali, Bünyami̇n Özaydin, Zeynep Gi̇ni̇ş, Yetki̇n Ağaçkiran, Namik Deli̇baş Jan 2015

Vitamin E Modulates Lung Oxidative Stress, Serum Copper, Zinc, And Iron Levels In Rats With Pulmonary Contusion, Mehmet Sirmali, Okan Solak, Tali̇p Çevi̇k, Rana Sirmali, Bünyami̇n Özaydin, Zeynep Gi̇ni̇ş, Yetki̇n Ağaçkiran, Namik Deli̇baş

Turkish Journal of Medical Sciences

To evaluate the effects of oxidant/antioxidant mechanisms and levels of trace elements on trauma-stimulated moderate pulmonary contusions after vitamin E administration. Materials and methods: Sixty-three male Sprague Dawley rats were used. Animals were studied in 4 groups. Vitamin E (150 mg/kg) was injected intraperitoneally 30 min after trauma and on the first and second days. Blood samples were obtained for nitric oxide (NO) levels and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities. Zinc (Zn^{+2}), copper (Cu^{+2}), and iron (Fe^{+3}) were measured in serum. Results: Lung contusion increased serum and tissue NO levels and SOD activities and decreased GSH-Px activities …

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Beraprost Sodium, A Prostacyclin (Pgi) Analogue, Ameliorateslipopolysaccharide-Induced Cellular Injury In Lung Alveolar Epithelial Cells, Si̇nan Vicil, Suat Erdogan Jan 2015

Beraprost Sodium, A Prostacyclin (Pgi) Analogue, Ameliorateslipopolysaccharide-Induced Cellular Injury In Lung Alveolar Epithelial Cells, Si̇nan Vicil, Suat Erdogan

Turkish Journal of Medical Sciences

Human alveolar epithelial cells play a critical role in the pathogenesis of lung diseases. The objective of this study is to determine the contribution of beraprost sodium, a prostaglandin I_2 (PGI_2) analogue, to inflammatory and oxidative events in response to lipopolysaccharide (LPS) in airway epithelial cells. Materials and methods: Human pulmonary alveolar epithelial cells (A549) were pretreated with 10 µM beraprost sodium 30 min before stimulation with 1 µg/mL LPS for 24 h. The cellular viability assessments were evaluated by quantitative MTT test. Catalase activity and glutathione and lipid peroxidation levels were determined using spectrophotometric techniques. mRNA expression analyses were …

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The First Ptpn11 Mutations In Hotspot Exons Reported In Moroccan Children With Noonan Syndrome And Comparison Of Mutation Rate To The Previous Studies, Ihssane El Bouchikhi, Imane Samri, Mohammed Iraqui Houssaini, Saaid Trhanint, Laila Bouguenouch, Hanane Sayel, Moustapha Hida, Samir Atmani, Karim Ouldim Jan 2015

The First Ptpn11 Mutations In Hotspot Exons Reported In Moroccan Children With Noonan Syndrome And Comparison Of Mutation Rate To The Previous Studies, Ihssane El Bouchikhi, Imane Samri, Mohammed Iraqui Houssaini, Saaid Trhanint, Laila Bouguenouch, Hanane Sayel, Moustapha Hida, Samir Atmani, Karim Ouldim

Turkish Journal of Medical Sciences

Background/aim: Noonan syndrome is an autosomal dominant disorder with an incidence of 1/1000?2500. It results from protein-tyrosine phosphatase, nonreceptor type 11 (PTPN11) mutations in roughly 50% of cases. Mutational screening of PTPN11 has been carried out in different populations. Thus, the aim of this study was to screen, for the first time, PTPN11 mutations in a series of Moroccan Noonan syndrome patients. Materials and methods: We used bidirectional sequencing of exons 3 and 8, considered as PTPN11 mutation hot spots, and then compared the rate of mutational events of these exons between different populations using chi-square and Fisher?s exact tests. …

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Hemodynamic Effects Of Atrial Natriuretic Peptide In Ischemia-Reperfusioninjury That Occurs After Exercise, Selma Arzu Vardar, Orki̇de Palabiyik, Ruhan Deni̇z Topuz, Eli̇f Ezgi̇ Gürel, Semra Çalişkan, Serap Topcu Özen, Necdet Süt, Çeti̇n Hakan Karadağ Jan 2015

Hemodynamic Effects Of Atrial Natriuretic Peptide In Ischemia-Reperfusioninjury That Occurs After Exercise, Selma Arzu Vardar, Orki̇de Palabiyik, Ruhan Deni̇z Topuz, Eli̇f Ezgi̇ Gürel, Semra Çalişkan, Serap Topcu Özen, Necdet Süt, Çeti̇n Hakan Karadağ

Turkish Journal of Medical Sciences

Atrial natriuretic peptide (ANP) is known as a protective agent against ischemia-reperfusion injury for cardiomyocytes. We compared the hemodynamic effects of ANP and isatin, which is known as an ANP receptor blocker, in ischemia followed by reperfusion in exercised rat hearts with nonexercised ones. Materials and methods: Isolated hearts were perfused in 4 exercised (E) groups after a running protocol for 5 days and 4 nonexercised (NE) groups. In the first protocol, ANP was added to the perfusion solution before ischemia in an E and NE group. In the second protocol, different doses of isatin (0.1, 10, 100 µM/L) were …

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Urodynamic Disorders And Renal Scarring In Pediatric Patients With Nonmonosymptomatic Nocturnal Enuresis, Orkun Tolunay, Necla Buyan, Mustafa Özgür Tan, Hüsnü Oğuz Söylemezoğlu, Hati̇ce Ki̇bri̇ya Fi̇dan, Sevcan Azi̇me Bakkaloğlu Ezgü Jan 2015

Urodynamic Disorders And Renal Scarring In Pediatric Patients With Nonmonosymptomatic Nocturnal Enuresis, Orkun Tolunay, Necla Buyan, Mustafa Özgür Tan, Hüsnü Oğuz Söylemezoğlu, Hati̇ce Ki̇bri̇ya Fi̇dan, Sevcan Azi̇me Bakkaloğlu Ezgü

Turkish Journal of Medical Sciences

Background/aim: In nonmonosymptomatic nocturnal enuresis (NMNE), the incidence of organic abnormality and urodynamic disorder is more frequent than the general population. The aim of this study is to identify urodynamic disorders and renal scarring in children with NMNE. Materials and methods: This study evaluated the urodynamic disorders and renal scarring of a total of 30 patients who were diagnosed with NMNE. A video-urodynamic test and Tc-99m dimercaptosuccinic acid renal scintigraphy were applied. Results: Records of 605 patients who had been diagnosed with enuresis were analyzed, and 215 (33.5%) of them had been diagnosed with NMNE. Thirty patients older than 6 …

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Evaluation Of Children Presenting To The Emergency Room After Electrical Injury, Aslihan Arasli Yilmaz, Ali̇ Osman Köksal, Osman Özdemi̇r, Mehtap Acar, Gülten Küçükkonyali, Yasemi̇n İnan, Si̇bel Çeli̇k, Mi̇ne Güveloğlu, Nesi̇be Andiran, Saci̇t Günbey Jan 2015

Evaluation Of Children Presenting To The Emergency Room After Electrical Injury, Aslihan Arasli Yilmaz, Ali̇ Osman Köksal, Osman Özdemi̇r, Mehtap Acar, Gülten Küçükkonyali, Yasemi̇n İnan, Si̇bel Çeli̇k, Mi̇ne Güveloğlu, Nesi̇be Andiran, Saci̇t Günbey

Turkish Journal of Medical Sciences

Background/aim: To evaluate children who presented to the Pediatric Emergency Department with electrical injury and to discuss the follow-up of these cases and potential precautions that can be taken. Materials and methods: A total of 36 patients presented to the Pediatric Emergency Department with electrical injury between May 2010 and May 2013, and these cases were investigated retrospectively. The patients? age and sex, location and form of exposure to electric current, seasonal distribution, length of hospital stay, musculoskeletal and cardiovascular system complications, renal damage, and treatments were recorded. Results: The majority of the patients were exposed to low-voltage electrical current …

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Efficacy And Safety Of Intralesional Corticosteroid Application For Hemangiomas, Suna Emi̇r, Di̇lek Gürlek Gökçebay, Fatma Demi̇rel, Bahatti̇n Tunç Jan 2015

Efficacy And Safety Of Intralesional Corticosteroid Application For Hemangiomas, Suna Emi̇r, Di̇lek Gürlek Gökçebay, Fatma Demi̇rel, Bahatti̇n Tunç

Turkish Journal of Medical Sciences

Background/aim: There are different modalities for management of infantile hemangiomas (IHs). In this report, our aim is to evaluate whether intralesional corticosteroid treatment is associated with systemic side effects and whether this is an effective treatment modality for IH. Materials and methods: Six children treated with intralesional corticosteroids for problematic hemangiomas were included in the study. Clinical characteristics, response to treatment, weight, height, blood pressure, morning serum cortisol, and adrenocorticotropic hormone levels were recorded. Results: Each child received intralesional triamcinolone at a dose of 2 mg/kg for 2?5 injections at monthly intervals. Subjects were followed for 1 year. All patients …

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Cyp 2d6*4 Polymorphism And Interindividual Response Variation To Metoprolol Instage 1 Hypertensive Patients: No Association In A Rural Indian Population?, Rajagopal Ayyappadhas, Unnikrishnan Dhanalekshmi, Chelliah Jestin Jan 2015

Cyp 2d6*4 Polymorphism And Interindividual Response Variation To Metoprolol Instage 1 Hypertensive Patients: No Association In A Rural Indian Population?, Rajagopal Ayyappadhas, Unnikrishnan Dhanalekshmi, Chelliah Jestin

Turkish Journal of Medical Sciences

Background/aim: Genetic polymorphism of CYP2D6 shows diverse pharmacokinetic and pharmacodynamic variation. Therefore, the present work was designed to study the variation in therapeutic responses to metoprolol (MP) in stage 1 hypertensive patients and also aims to verify the association of CYP2D6*4 polymorphism and response variation in an Indian population for the first time. Materials and methods: Clinically, a total of 119 hypertensive patients and 116 healthy individuals as controls were included. Patients were treated with MP extended release 25 mg tablets once daily for 2 weeks. Reduction in systolic blood pressure, diastolic blood pressure, and pulse rate were recorded before …

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Premarital Screening Of 466 Mediterranean Women For Serum Ferritin,Vitamin B12, And Folate Concentrations, Aysun Karabulut, Ömer Tolga Güler, Hati̇ce Tuba Karahan, Sevgi̇ Özkan, Hasan Koyuncu, İbrahi̇m Demi̇rci̇ler Jan 2015

Premarital Screening Of 466 Mediterranean Women For Serum Ferritin,Vitamin B12, And Folate Concentrations, Aysun Karabulut, Ömer Tolga Güler, Hati̇ce Tuba Karahan, Sevgi̇ Özkan, Hasan Koyuncu, İbrahi̇m Demi̇rci̇ler

Turkish Journal of Medical Sciences

Background/aim: Iron, folate, and vitamin B12 serum levels are closely related with dietary habits and have an essential role in the healthy development of a fetus. We aimed to investigate hemoglobin, ferritin, folate, and vitamin B12 levels in preconceptional women in an area where a plant-based diet referred to as Mediterranean cuisine is commonly used. Materials and methods: The study population included 466 women between the ages of 18 and 45 years admitted for thalassemia screening. Sociodemographic variables and history of menometrorrhagia, pica, and dietary habits were collected. Serum vitamin B12, folate, ferritin, and hemoglobin levels were measured. Ferritin of

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Retracted - Quantitative Study Of Epigenetic Signature In Head And Necksquamous Cell Carcinoma, Ayesha Umair, Bassel Tarakji, Alzoghaibi Ibrahim, Azzeghaibi Nasser, Alenzi Fq, Ayesha Shreen Jan 2015

Retracted - Quantitative Study Of Epigenetic Signature In Head And Necksquamous Cell Carcinoma, Ayesha Umair, Bassel Tarakji, Alzoghaibi Ibrahim, Azzeghaibi Nasser, Alenzi Fq, Ayesha Shreen

Turkish Journal of Medical Sciences

Background/aim: The aberrant upregulation of Forkhead box protein M1 (FOXM1) plays a fundamental role in cancer initiation by perturbing stem cell differentiation. This study aims to investigate the role of FOXM1 in epigenetic modification and gene expression of target genes in primary human oral keratinocytes, squamous cell carcinoma cell lines, and head and neck squamous cell carcinoma (HNSCC) tissue biopsies. Materials and methods: A genome-wide promoter methylation microarray was used to compare HNSCC cell line (n = 8), primary human oral keratinocytes (NOK; n = 8) transduced with FOXM1 and EGFP, and HNSCC tissue biopsies (n = 3). Seventeen Foxm1B-induced …

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Two Gastrointestinal Conditions With Similar Symptoms And Endoscopicappearance: Irritable Bowel Syndrome And Microscopic Colitis, Zahi̇de Şi̇mşek, Nazi̇fe Candan Tunçer, Hakan Alagözlü, Fati̇h Karaahmet, Şahi̇n Çoban, Ayşe Dursun Jan 2015

Two Gastrointestinal Conditions With Similar Symptoms And Endoscopicappearance: Irritable Bowel Syndrome And Microscopic Colitis, Zahi̇de Şi̇mşek, Nazi̇fe Candan Tunçer, Hakan Alagözlü, Fati̇h Karaahmet, Şahi̇n Çoban, Ayşe Dursun

Turkish Journal of Medical Sciences

Background/aim: Irritable bowel syndrome (IBS) is a gastrointestinal condition characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any organic cause. This trial investigated the presence of microscopic colitis (MC) and associated factors related to MC in patients diagnosed with IBS. Materials and methods: The study group (group I) consisted of 91 consecutive patients diagnosed with IBS based on the Rome III Criteria for whom colonoscopic examination was requested. The control group (group II) had 41 patients diagnosed with IBS considered as eligible for colonoscopic investigation due to specific conditions, and for whom …

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The Relationship Between Hepatitis Serology Of Ambulance Attendants Andduration Of Education, Ertuğrul Güçlü, Azi̇z Öğütlü, Oğuz Karabay Jan 2015

The Relationship Between Hepatitis Serology Of Ambulance Attendants Andduration Of Education, Ertuğrul Güçlü, Azi̇z Öğütlü, Oğuz Karabay

Turkish Journal of Medical Sciences

Background/aim: Healthcare workers (HCWs) run the risk of hepatitis B virus (HBV) infection. Studies investigating the HBV and hepatitis C virus (HCV) serology of HCWs have been generally conducted in secondary or tertiary hospitals. In this study we aimed to determine the relationships between education level and HBV and HCV serology and HBV vaccination status of ambulance attendants. Materials and methods: The data of this study were obtained by retrospective review of ambulance personnel files in Sakarya Province, Turkey. Results: Out of 314 ambulance attendants, 216 (68.7%; 78 males, 138 females) were enrolled in this study. The mean length of …

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Trace Elements Levels In The Serum, Urine, And Semen Of Patients With Infertility, Hasan Sali̇h Sağlam, Hüseyi̇n Altundağ, Yavuz Tarik Ati̇k, Mustafa Şahi̇n Dündar, Öztuğ Adsan Jan 2015

Trace Elements Levels In The Serum, Urine, And Semen Of Patients With Infertility, Hasan Sali̇h Sağlam, Hüseyi̇n Altundağ, Yavuz Tarik Ati̇k, Mustafa Şahi̇n Dündar, Öztuğ Adsan

Turkish Journal of Medical Sciences

Background/aim: Studies suggest that trace elements may have an adverse impact on male reproduction, even at low levels. We tried to investigate the relationships between these metals and semen quality in various body fluids among men with infertility. Materials and methods: A total of 255 samples of blood, semen, and urine were collected from 85 men suffering from infertility. Inductively coupled plasma-optical emission spectrometry was used for the determination of 22 trace elements. We compared the results of the semen parameters with the results of the element determinations. Results: Because of the high proportion of samples with values lower than …

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Malondialdehyde And Nitric Oxide Levels And Catalase, Superoxide Dismutase, And Glutathione Peroxidase Levels In Maternal Blood During Different Trimesters Ofpregnancy And In The Cord Blood Of Newborns, Sevda Yüksel, Ayşe Arzu Yi̇ği̇t Jan 2015

Malondialdehyde And Nitric Oxide Levels And Catalase, Superoxide Dismutase, And Glutathione Peroxidase Levels In Maternal Blood During Different Trimesters Ofpregnancy And In The Cord Blood Of Newborns, Sevda Yüksel, Ayşe Arzu Yi̇ği̇t

Turkish Journal of Medical Sciences

Background/aim: To determine whether levels of malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) change during the 3 trimesters of pregnancy, and to compare the third trimester of pregnancy with newborn cord blood in respect to the levels of MDA, NO, and antioxidant enzymes. Materials and methods: Maternal blood samples were collected at 9?13, 22?26, and 36?40 weeks of gestation. Cord blood was collected at the time of delivery. Results: NO levels and GPx activity were higher in the second and third trimesters than in the first trimester. MDA level was lower in the …

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Human Papillomavirus: A Potential Risk Factor For Colorectal Carcinoma?, Ufuk Berber, Alpaslan Tanoğlu, Ahmet Zi̇ya Balta Jan 2015

Human Papillomavirus: A Potential Risk Factor For Colorectal Carcinoma?, Ufuk Berber, Alpaslan Tanoğlu, Ahmet Zi̇ya Balta

Turkish Journal of Medical Sciences

No abstract provided.

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Pandemic H1n1 Igg Levels In Healthcare Workers, Viroj Wiwanitkit Jan 2015

Pandemic H1n1 Igg Levels In Healthcare Workers, Viroj Wiwanitkit

Turkish Journal of Medical Sciences

No abstract provided.

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Effects Of Grape Seed Extract On Oxidative Stress And Antioxidant Defensemarkers In Streptozotocin-Induced Diabetic Rats, Muaz Belvi̇ranli, Hakki Gökbel, Ni̇lsel Okudan, Sadik Büyükbaş Jan 2015

Effects Of Grape Seed Extract On Oxidative Stress And Antioxidant Defensemarkers In Streptozotocin-Induced Diabetic Rats, Muaz Belvi̇ranli, Hakki Gökbel, Ni̇lsel Okudan, Sadik Büyükbaş

Turkish Journal of Medical Sciences

Background/aim: To evaluate the effects of grape seed extract (GSE) supplementation on oxidative stress and antioxidant markers in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Thirty-six male rats were divided into the following four groups: control, GSE-supplemented control, diabetic, and GSE-supplemented diabetic. Beginning on day 7 after STZ injection, the rats were administered GSE (100 mg kg-1 day-1) in drinking water for 6 weeks. At the end of week 6, rats were sacrificed by cardiac puncture. Plasma nitric oxide (NO) levels and xanthine oxidase (XO), adenosine deaminase (ADA), and glutathione peroxidase (GPx) activities were analyzed. Results: Both XO and ADA …

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Toxic Potentials Of Ten Herbs Commonly Used For Aphrodisiac Effect In Turkey, Mahmoud Abudayyak, Ebru Özdemi̇r Nath, Gül Özhan Jan 2015

Toxic Potentials Of Ten Herbs Commonly Used For Aphrodisiac Effect In Turkey, Mahmoud Abudayyak, Ebru Özdemi̇r Nath, Gül Özhan

Turkish Journal of Medical Sciences

Background/aim: Sexual dysfunction is a serious problem worldwide. In Turkey, herbal products are used by some people suffering from sexual dysfunction. Despite their therapeutic advantages, some constituents of herbs are potentially toxic and pose health risks because they can be bought from the market without a prescription. Therefore, we aimed to determine the safety of herbs possessing aphrodisiac effects, chosen on the basis of their frequency of medicinal use and commercial importance in Turkey. Materials and methods: Ten herbs (Anethum graveolens, Carthamus tinctorius, Citrus aurantium, Cocos nucifera, Glycyrrhiza glabra, Melissa officinalis, Nigella arvensis, Pinus pinea, Prunus mahaleb, and Zingiber officinale) …

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Prevention Of Methotrexate-Induced Nephrotoxicity By Concomitantadministration Of Garlic Aqueous Extract In Rat, Walaa Ahmed, Amr Zaki, Taghred Nabil Jan 2015

Prevention Of Methotrexate-Induced Nephrotoxicity By Concomitantadministration Of Garlic Aqueous Extract In Rat, Walaa Ahmed, Amr Zaki, Taghred Nabil

Turkish Journal of Medical Sciences

Background/aim: Methotrexate (MTX) has been widely used for treatment of cancer and rheumatoid arthritis, but its use has been limited by its nephrotoxicity. This study was carried out to determine whether garlic exerts a protective effect against MTX-induced nephrotoxicity. Materials and methods: Nephrotoxicity was induced in rats after a single i.p. injection of MTX (20 mg/kg). Garlic extract (1 mL/100 g b.w.) was given orally for 7 days before and after MTX administration. Serum samples were collected to evaluate urea, creatinine, sodium, phosphorous, potassium, and calcium. Reduced glutathione, catalase, adenosine deaminase, nitric oxide, and malondialdehyde were measured in renal tissue. …

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The Effect Of Vitamin E And L-Carnitine Against Methotrexate-Induced Injury In Rat Testis, Mehmet Yüncü, Nezahat Bükücü, Nuray Bayat, Leman Sencar, Mehmet Tarakçioğlu Jan 2015

The Effect Of Vitamin E And L-Carnitine Against Methotrexate-Induced Injury In Rat Testis, Mehmet Yüncü, Nezahat Bükücü, Nuray Bayat, Leman Sencar, Mehmet Tarakçioğlu

Turkish Journal of Medical Sciences

Background/aim: Methotrexate (MTX), used commonly as an antimetabolite drug in cancer therapy, leads to acute toxic side effects in tissues or organs containing rapidly dividing cells, such as bone marrow, gastrointestinal mucosa, and seminiferous tubules. In this study, we investigated the protective effects of vitamin E and L-carnitine against MTX-induced injury in rat testis. Materials and methods: Rats were divided into 4 groups, including the control group. The study took 17 days and the animals received daily doses of 0.5 mL/kg saline, 250 mg/kg vitamin E, or 500 mg/kg L-carnitine intraperitoneally. The experimental groups received 20 mg/kg methotrexate intraperitoneally on …

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Caffeic Acid Phenethyl Ester Protects Lung Alveolar Epithelial Cellsfrom Cigarette Smoke-Induced Damage, Firat Bariş Barlas, Suat Erdogan Jan 2015

Caffeic Acid Phenethyl Ester Protects Lung Alveolar Epithelial Cellsfrom Cigarette Smoke-Induced Damage, Firat Bariş Barlas, Suat Erdogan

Turkish Journal of Medical Sciences

Background/aim: To evaluate the influence of caffeic acid phenethyl ester (CAPE) on cigarette smoke (CS)-induced cell damage, oxidative stress, and inflammation in human alveolar epithelial cells. Materials and methods: A549 alveolar epithelial cells were divided into control, CS exposure, CAPE, and CS+CAPE treatment groups. Undiluted CS-exposed medium (100%) and three dilutions (50%, 25%, and 10%) of CS-exposed media were applied to cultured A549 cells, which were analyzed after 3 h of incubation. Viability was measured by MTT assay, the gene expressions were evaluated by real-time PCR, and spectrophotometric techniques were used for biochemical assessments. Results: While CS exposure markedly reduced …

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Effect Of Pioglitazone, Quercetin, And Hydroxy Citric Acid On Vascular Endothelial Growth Factor Messenger Rna (Vegf Mrna) Expression In Experimentally Induced Nonalcoholic Steatohepatitis (Nash)*, Surapaneni Krishna Mohan, Vishnu Priya Veeraraghavan, Mallika Jainu Jan 2015

Effect Of Pioglitazone, Quercetin, And Hydroxy Citric Acid On Vascular Endothelial Growth Factor Messenger Rna (Vegf Mrna) Expression In Experimentally Induced Nonalcoholic Steatohepatitis (Nash)*, Surapaneni Krishna Mohan, Vishnu Priya Veeraraghavan, Mallika Jainu

Turkish Journal of Medical Sciences

Background/aim: Vascular endothelial growth factor (VEGF) is associated with various ischemic and inflammatory diseases, and plays an important role in the development of liver fibrosis and hepatocarcinogenesis in nonalcoholic steatohepatitis (NASH). In this study, the comparative effect of pioglitazone, quercetin, and hydroxy citric acid on VEGF mRNA in experimentally induced NASH was investigated. Materials and methods: The experimental protocol consisted of five groups: control, NASH, NASH + pioglitazone, NASH + quercetin, and NASH + hydroxy citric acid. The VEGF mRNA expression was evaluated by reverse transcription polymerase chain reaction (RT-PCR) analysis for all experimental groups, and the levels of VEGF …

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Characterization Of Hcv Genotype 4d Infections In Kayseri, Turkey*, Tuba Kayman, Ceylan Polat, Gül Ergör, Yusuf Hakan Abacioğlu Jan 2015

Characterization Of Hcv Genotype 4d Infections In Kayseri, Turkey*, Tuba Kayman, Ceylan Polat, Gül Ergör, Yusuf Hakan Abacioğlu

Turkish Journal of Medical Sciences

Background/aim: The frequency of genotype 4 hepatitis C virus (HCV) infections is significantly higher in Kayseri compared to other provinces in Turkey. We aimed to characterize genotype 4 infections in Kayseri by analyzing the demographic and laboratory data of 218 HCV RNA-positive, treatment-naive patients admitted to the Kayseri Training and Research Hospital in 2010 and 2011. Materials and methods: The distributions of sex, age, and viral loads of these patients with respect to HCV genotypes were analyzed. We also characterized the type 4 sequences at the subtype level. Randomly selected sera from 32 of the 72 genotype 4 patients from …

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Clinical Characteristics Of 75 Pandemic H1n1 Influenza Patientsfrom Turkey; Risk Factors For Fatality, Hati̇ce Kiliç, Asi̇ye Kanbay, Ayşegül Karalezli̇, Hati̇ce Canan Hasanoğlu, Can Ateş Jan 2015

Clinical Characteristics Of 75 Pandemic H1n1 Influenza Patientsfrom Turkey; Risk Factors For Fatality, Hati̇ce Kiliç, Asi̇ye Kanbay, Ayşegül Karalezli̇, Hati̇ce Canan Hasanoğlu, Can Ateş

Turkish Journal of Medical Sciences

Background/aim: The 2009 influenza A (H1N1) pandemic caused mild to severe illnesses and led to death in some cases. In this study, we aimed to evaluate the relationship between the serum D-dimer levels, CURB-65 scores, and the severity of pneumonia among patients with H1N1 infections. Materials and methods: Sixty-eight patients who had probable H1N1 infections were evaluated by clinical, radiological, and laboratory methods. The H1N1 strain was specified by reverse transcription-polymerase chain reaction. Of 55 patients diagnosed with pneumonia, 18 exhibited H1N1 positivity and 37 patients did not. Results: CURB-65 scores of pneumonia patients with H1N1 (group 1) were higher …

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Correlation Between Antibiotic Resistance And Virulence Ofpseudomonas Aeruginosa Clinical Isolates, Fatma Ibrahim Sonbol, Maha Abd El Fattah Khalil, Abdelfattah Badr Mohamed, Sameh Samir Ali Jan 2015

Correlation Between Antibiotic Resistance And Virulence Ofpseudomonas Aeruginosa Clinical Isolates, Fatma Ibrahim Sonbol, Maha Abd El Fattah Khalil, Abdelfattah Badr Mohamed, Sameh Samir Ali

Turkish Journal of Medical Sciences

Background/aim: Virulent Pseudomonas aeruginosa is frequently life-threatening and often challenging to treat, and the emergence of multidrug-resistant isolates presents a critical problem for patients. The aim of the study was concerned with molecular analysis of the virulence factors and antimicrobial resistance profile of multidrug-resistant P. aeruginosa (MDRPA). Materials and methods: Out of 44 MDRPA isolates, 12 isolates representing different resistance profiles and sources of samples were selected for further molecular studies. Polymerase chain reaction (PCR) approaches were applied to identify the genes implicated in antimicrobial resistance or virulence factors in the selected MDRPA isolates. Results: Multidrug-resistance (pstS), ß-lactamase (IMP7, IMP10, …

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Comparison Of The Contamination Rates Of Culture Media Used For Isolation And Identification Of Dermatophytes, Ramazan Gümral, Ayli̇n Döğen, Mehmet Maci̇t İlki̇t Jan 2015

Comparison Of The Contamination Rates Of Culture Media Used For Isolation And Identification Of Dermatophytes, Ramazan Gümral, Ayli̇n Döğen, Mehmet Maci̇t İlki̇t

Turkish Journal of Medical Sciences

Background/aim: Mycological media that promote spore production are essential for the diagnosis of dermatophytosis. However, these culture media frequently become contaminated by multiple fungal or bacterial species during culture. The aim of this study was to compare the contamination rates of 6 culture media used for the isolation and identification of dermatophytes, including Borelli's lactritmel agar (BLA), brain-heart infusion agar (BHIA), Lowenstein-Jensen agar (LJA), malt extract agar (MEA), potato dextrose agar (PDA), and Sabouraud glucose agar (SGA). Materials and methods: Agar plates were inoculated with 43 well-characterized dermatophyte strains, belonging to the genera Arthroderma, Epidermophyton, Microsporum, or Trichophyton. The agar …

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Elevated Serum Matrix Metalloproteinase-2 And -9 And Their Correlationswith Severity Of Disease In Patients With Community-Acquired Pneumonia, Haci Ahmet Bi̇rcan, Müni̇re Çakir, İlkay Yilmazer Kapulu, Recep Sütcü, Selçuk Kaya, Önder Öztürk Jan 2015

Elevated Serum Matrix Metalloproteinase-2 And -9 And Their Correlationswith Severity Of Disease In Patients With Community-Acquired Pneumonia, Haci Ahmet Bi̇rcan, Müni̇re Çakir, İlkay Yilmazer Kapulu, Recep Sütcü, Selçuk Kaya, Önder Öztürk

Turkish Journal of Medical Sciences

Background/aim: To determine the role of matrix metalloproteinases (MMPs) and their relationship with the clinical course of community-acquired pneumonia (CAP). Materials and methods: Sixty-two consecutively hospitalized patients with CAP were enrolled and their pneumonia severity index (PSI), time to clinical stability (TCS), treatment response, and complications were recorded. The pre- and posttreatment serum concentrations of MMPs and their inhibitors were analyzed by ELISA. The activities of MMPs were evaluated by gelatin zymography. Results: MMP-2 and -9 serum levels and their activities were higher in CAP patients than controls (P < 0.001 and P < 0.001, respectively). Low-risk patients had lower levels of MMP-2 and TIMP-1 than high-risk patients (P = 0.044, P = 0.001, respectively). Pretreatment serum TIMP-1 level was higher in patients with TCS of >3 days (P = 0.004) and was correlated with oxygenation and …

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Correlation Between Serum Levels Of Vitamin B12 And Anti-Helicobacter Pyloriiga Antibodies In Vitamin B12 Deficient Palestinian Patients, Rasmi Abu Hilu, Osama Dudeen, Sameer Abdullatif Barghouthi Jan 2015

Correlation Between Serum Levels Of Vitamin B12 And Anti-Helicobacter Pyloriiga Antibodies In Vitamin B12 Deficient Palestinian Patients, Rasmi Abu Hilu, Osama Dudeen, Sameer Abdullatif Barghouthi

Turkish Journal of Medical Sciences

Background/aim: H. pylori infection and vitamin B12 (vB12) deficiency have high prevalence rates among Palestinians. It was observed that most people who suffered from vB12 deficiency were positive for H. pylori. Materials and methods: The correlation between H. pylori infection and vB12 deficiency was investigated in a representative segment of the Palestinian population. ELISA was used to determine levels of vitamin B12 (vB12) and anti-H. pylori IgA in sera from 238 participants from Al-Khalil district (Hebron), Palestine. Results: There was a strong negative Pearson's correlation coefficient (r = -0.45; P = 0.00001) between levels of anti-H. pylori IgA and vB12 …

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