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2015

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Articles 9661 - 9690 of 11981

Full-Text Articles in Medicine and Health Sciences

The Effect Of Bacterial Vaginosis Associated Bacteria On Epithelial Factors Mediating Hiv Transmission, April Nguyen Jan 2015

The Effect Of Bacterial Vaginosis Associated Bacteria On Epithelial Factors Mediating Hiv Transmission, April Nguyen

HIM 1990-2015

Bacterial vaginosis (BV), a common female reproductive tract (FRT) condition characterized by an overgrowth of anaerobic species concurrent with the disappearance of commensal Lactobacilli species, is associated with a 60% increased risk of HIV-1 transmission. However, the role of the FRT epithelia in bacterial vaginosis-associated bacteria (BVAB)-augmented HIV- 1 transmission is unclear. To evaluate the increased risk of HIV-1 acquisition, we treated FRT epithelia with Atopobium vaginae, a prevalent BVAB, to determine the nature of the host response to BVAB exposure. Treatment of endocervical cells with A. vaginae resulted in a 1500-fold increase in the expression of the antimicrobial peptide …

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Sports Massage Research Protocols And Industry Standards, Amber Kest Jan 2015

Sports Massage Research Protocols And Industry Standards, Amber Kest

HIM 1990-2015

The purpose of this study was to determine which MT techniques current licensed massage therapists practicing sports massage are using to treat delayed onset muscle soreness (DOMS) by conducting an anonymous online survey of practicing sports massage therapists. The secondary purpose was to determine if previous sports massage research protocols match current practices in sports massage to treat DOMS. There were 85 anonymous respondents ranging in age from 24 to 74 years with a mean age of 44.5 years. Participants included 55 female (65.5%) and 29 male (34.5%) therapists. Professional experience ranged from 4 years or less to more than …

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Diabetes Phenotypes In Transgenic Pancreatic Cancer Mouse Models, Toya Albury-Warren Jan 2015

Diabetes Phenotypes In Transgenic Pancreatic Cancer Mouse Models, Toya Albury-Warren

Electronic Theses and Dissertations

Protein Kinase B/AKT, a serine/threonine kinase with three isoforms (AKT1-3), is downstream of phosphatidylinositol 3-kinase (PI3K), and signals through the phosphorylation and subsequent activation or inhibition of downstream substrates, such as mammalian target of rapamycin complex 1 (mTORC1) or glycogen synthase kinase 3 beta (GSK-3?), respectively. The AKT1 isoform is predominantly recognized for regulation of cell survival, growth, and proliferation, due to its constitutive activation in pancreatic cancers (e.g., islet cell carcinoma and pancreatic adenocarcinoma). The progression of pancreatic ductal adenocarcinoma (PDAC), the most lethal common cancer, is initiated by activation mutations of the KRas oncogene. This leads to additional …

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Rural Health Clinic Readiness For Patient-Centered Medical Home Recognition: Preparing For The Evolving Healthcare Marketplace [Policy Brief], John A. Gale Ms, Zachariah T. Croll Mph, David Hartley Phd, Mha, Andrew F. Coburn Phd Jan 2015

Rural Health Clinic Readiness For Patient-Centered Medical Home Recognition: Preparing For The Evolving Healthcare Marketplace [Policy Brief], John A. Gale Ms, Zachariah T. Croll Mph, David Hartley Phd, Mha, Andrew F. Coburn Phd

Rural Health Clinics

The patient-centered medical home (PCMH) model reaffirms traditional primary care values including continuity of care, connection with an identified personal clinician, provision of same day- and after-hours access, and positions providers to participate in accountable care and other financing and delivery system models. However, little is known about the readiness of the over 4,000 Rural Health Clinics (RHCs) to meet the PCMH Recognition standards established by the National Council for Quality Assurance (NCQA). The authors present findings from a survey of RHCs that examined their capacity to meet the NCQA PCMH requirements, and discuss the implications of the findings for …

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Rural Health Clinic Readiness For Patient-Centered Medical Home Recognition: Preparing For The Evolving Healthcare Marketplace [Working Paper], John A. Gale Ms, Zachariah T. Croll Mph, David Hartley Phd, Mha Jan 2015

Rural Health Clinic Readiness For Patient-Centered Medical Home Recognition: Preparing For The Evolving Healthcare Marketplace [Working Paper], John A. Gale Ms, Zachariah T. Croll Mph, David Hartley Phd, Mha

Rural Health Clinics

The patient-centered medical home (PCMH) model reaffirms traditional primary care values including continuity of care, connection with an identified personal clinician, provision of same day- and after-hours access, and positions providers to participate in accountable care and other financing and delivery system models. However, little is known about the readiness of the over 4,000 Rural Health Clinics (RHCs) to meet the PCMH Recognition standards established by the National Council for Quality Assurance (NCQA). The authors present findings from a survey of RHCs that examined their capacity to meet the NCQA PCMH requirements, and discuss the implications of the findings for …

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Gender-Biased Sex Selection In South Asia: The Situation And Promising Approaches To Restore Balance, Population Council Jan 2015

Gender-Biased Sex Selection In South Asia: The Situation And Promising Approaches To Restore Balance, Population Council

Poverty, Gender, and Youth

This project summary indicates that sex ratios at birth in South Asia vary considerably. While the sex ratios at birth in Bangladesh and Pakistan have been normal at the country level (103 and 102.5 males per 100 females, respectively), Nepal is showing signs of disturbed sex ratios at birth, with a sex ratio of 106 males per 100 females, and the situation in India is particularly adverse, with a sex ratio at birth of 110 males per 100 females. In all of these countries, preconditions for a deterioration of the sex ratio at birth are evident. Preferences are expressed for …

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Burnout: Absence Of Binding Diagnostic Criteria Hampers Prevalence Estimates, Renzo Bianchi, Irvin Sam Schonfeld, Eric Laurent Jan 2015

Burnout: Absence Of Binding Diagnostic Criteria Hampers Prevalence Estimates, Renzo Bianchi, Irvin Sam Schonfeld, Eric Laurent

Publications and Research

Comments on an article by Jef Adriaenssens et al. (see record 2015-00662-015). In a recent review paper, Adriaenssens et al. concluded that about 26% of emergency nurses (EN) suffer from burnout and described their results as alarming. While commentators applaud Adriaenssens et al. efforts to provide a clearer picture of ill-health in EN, they thought that these authors' conclusions were weakened by a fundamental fact, namely, the absence of consensual, clinically valid diagnostic criteria for burnout. Trying to determine the prevalence of a condition that has no binding diagnostic criteria is problematic. Indeed, depending on how researchers decide to …

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2-Dimension Analysis Of Frontal Plane Projection Angle In Female Soccer Athletes, Kylee M. Tuchfarber Jan 2015

2-Dimension Analysis Of Frontal Plane Projection Angle In Female Soccer Athletes, Kylee M. Tuchfarber

Undergraduate Distinction Papers

Research has found a variety of mechanisms for ACL injuries. One mechanism that has been found is a decreased valgus control at the knee. One study found that that “the decreased active and passive controls of knee alignments may destabilize the knee and are purported to be measures related to increased risk of ACL injury in female athletes, as they mature” (Myer, Ford, Khoury, Succop, & Hewett, 2011, 248). The age of the subjects (12-16) is important because maturation may be a contributing cause of knee abduction moments (KAM). Three-dimensionalanalysis has been said to be the “gold standard” when analyzing …

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Are E-Cigarettes An Optimal Choice For Harm Reduction For Tobacco Smokers?, Brenda Talley, Deborah Allen, Kathryn H. Anderson Jan 2015

Are E-Cigarettes An Optimal Choice For Harm Reduction For Tobacco Smokers?, Brenda Talley, Deborah Allen, Kathryn H. Anderson

Nursing: Faculty Presentations (1990-2022)

This presentation was given at the Sigma Theta Tau International Congress.

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Protective Effects Of Erdosteine, Vitamin E, And Vitamin C On Renal Injury Induced By The Ischemia-Reperfusion Of The Hind Limbs In Rats, Rana Sirmali, Abdullah Armağan, Faruk Öktem, Efkan Uz, Aynur Kirbaş, Soner Dönmez, Haci Ramazan Yilmaz, Mesrur Selçuk Silay, Mehmet Sirmali Jan 2015

Protective Effects Of Erdosteine, Vitamin E, And Vitamin C On Renal Injury Induced By The Ischemia-Reperfusion Of The Hind Limbs In Rats, Rana Sirmali, Abdullah Armağan, Faruk Öktem, Efkan Uz, Aynur Kirbaş, Soner Dönmez, Haci Ramazan Yilmaz, Mesrur Selçuk Silay, Mehmet Sirmali

Turkish Journal of Medical Sciences

To compare the protective efficacy of erdosteine and vitamins C and E against renal injury caused by hind limb ischemia-reperfusion (I/R). Materials and methods: Rats were split into 4 groups: group I as the control, group II as I/R, group III as I/R + erdosteine, and group IV as I/R + vitamins C and E. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) tissue levels were determined. Results: MDA levels were found comparable with the control group in groups II and III. However, they were considerably decreased in group IV when compared to group II …

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An In Vitro And In Vivo Investigation Of The Cytotoxic Effects Of Caffeic Acid (3,4-Dihydroxycinnamic Acid) Phenethyl Ester And Bortezomib In Multiple Myeloma Cells, Ertan Altayli, Özgür Koru, Önder Öngürü, Tayfun İde, Cengi̇zhan Açikel, Meral Sarper, Mualla Pinar Elçi̇, Rahşan Ilikçi Sağkan, Erhan Astarci, Duran Tok, Sali̇m Özenç, Ali̇ Uğur Ural, Feri̇t Avcu Jan 2015

An In Vitro And In Vivo Investigation Of The Cytotoxic Effects Of Caffeic Acid (3,4-Dihydroxycinnamic Acid) Phenethyl Ester And Bortezomib In Multiple Myeloma Cells, Ertan Altayli, Özgür Koru, Önder Öngürü, Tayfun İde, Cengi̇zhan Açikel, Meral Sarper, Mualla Pinar Elçi̇, Rahşan Ilikçi Sağkan, Erhan Astarci, Duran Tok, Sali̇m Özenç, Ali̇ Uğur Ural, Feri̇t Avcu

Turkish Journal of Medical Sciences

In this study, the in vitro and in vivo effectiveness of caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) in combination with bortezomib, a proteasome inhibitor, was explored in multiple myeloma (MM) cells. Materials and methods: The cytotoxic effects of CAPE and bortezomib were determined by XTT cell proliferation assay. Apoptosis levels were analyzed with annexin V-fluorescein isothiocyanate, nuclear factor kappa beta (NF-\kappaB) was analyzed with electrophoretic mobility-shift assay, and interleukin (IL)-6 levels were analyzed with enzyme-linked immunosorbent assay to evaluate CAPE's mechanism of action. To investigate the in vivo effectiveness of CAPE and bortezomib, an experimental plasmacytoma model was induced …

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Effects On Quinolone Resistance Due To The Biofilm Formation Activity In Ureaplasma Urealyticum, Chunyan Feng, Ya Huang, Yunsong Yu, Guorong Duan, Yuying Dai, Ke Dong, Qingtian Li Jan 2015

Effects On Quinolone Resistance Due To The Biofilm Formation Activity In Ureaplasma Urealyticum, Chunyan Feng, Ya Huang, Yunsong Yu, Guorong Duan, Yuying Dai, Ke Dong, Qingtian Li

Turkish Journal of Medical Sciences

To detect the effects on quinolone resistance due to biofilm formation activity in Ureaplasma urealyticum. Materials and methods: An improved checkerboard dilution susceptibility test was used to analyze the quinolone resistance of clinical Ureaplasma isolates and a postbiofilm formation susceptibility assay was used to compare the effects on the quinolone susceptibility between pre- and postbiofilm formations. Several important functional gene expressions were detected to evaluate their roles in the process of the quinolone resistance mechanism. Results: The quinolone-resistant isolates produced more biofilms than the sensitive isolates. In both the quinolone-resistant and -sensitive groups, the minimal inhibitory concentrations after biofilm formation …

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Comparative Study Of Virulence Factors Among Esβl-Producing And Nonproducing Pseudomonas Aeruginosa Clinical Isolates, Maha Abd El Fattah Khalil, Fatma Ibrahim Sonbol, Abdelfattah Badr, Samh Samir Ali Jan 2015

Comparative Study Of Virulence Factors Among Esβl-Producing And Nonproducing Pseudomonas Aeruginosa Clinical Isolates, Maha Abd El Fattah Khalil, Fatma Ibrahim Sonbol, Abdelfattah Badr, Samh Samir Ali

Turkish Journal of Medical Sciences

\beta-Lactamase production is considered one of the most important resistance mechanisms among virulent Pseudomonas aeruginosa isolates. The aim of this study was to compare the production and antimicrobial resistance patterns of some virulence factors in extended spectrum \beta-lactamase (ES\betaL)-producing and nonproducing P. aeruginosa clinical isolates. Materials and methods: Out of 183 different clinical specimens, 104 Pseudomonas aeruginosa isolates were recovered. The isolates were screened for ESbL production using the double disk diffusion test and phenotypic confirmatory disk diffusion test. All isolates were tested for susceptibility to 25 antimicrobials, as well as for expression of various virulence factors including pigment, hemolysin, …

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Distribution Of Viral Genotypes And Extrahepatic Manifestations In Patients With Chronic Hepatitis C In Eastern Turkey, Si̇bel İba Yilmaz, Serpi̇l Erol, Ahmet Özbek, Mehmet Parlak Jan 2015

Distribution Of Viral Genotypes And Extrahepatic Manifestations In Patients With Chronic Hepatitis C In Eastern Turkey, Si̇bel İba Yilmaz, Serpi̇l Erol, Ahmet Özbek, Mehmet Parlak

Turkish Journal of Medical Sciences

To investigate the distribution of viral genotypes, the extrahepatic manifestations, and the relationship between genotypes and extrahepatic manifestations in patients with chronic hepatitis C. Materials and methods: The study included 62 treatment-naive patients with chronic hepatitis C infection. Genotype determination was performed by DNA sequencing analysis. To investigate extrahepatic manifestations, the patients' data, recorded prospectively during the pretreatment period, were analyzed. Results: Genotype determination was successful in 74.2% of the cases. All patients were infected with hepatitis C virus (HCV) genotype 1b. At least 1 extrahepatic manifestation was identified in 37.1% of the patients. The most frequent clinical manifestations were …

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A Molecular Epidemiological Investigation Of Multistate Outbreaks Of Salmonella Enteritidis From Clinical And Environmental Samples In Turkey, 2000-2010, Sümeyra Acar, Belkis Levent, Ekrem Atalan Jan 2015

A Molecular Epidemiological Investigation Of Multistate Outbreaks Of Salmonella Enteritidis From Clinical And Environmental Samples In Turkey, 2000-2010, Sümeyra Acar, Belkis Levent, Ekrem Atalan

Turkish Journal of Medical Sciences

To analyze interrelated Salmonella Enteritidis strains isolated in Turkey. Fifty-five S. Enteritidis surveillance strains were isolated from human feces and environmental samples from different regions in Turkey between 2000 and 2010. Materials and methods: Clinical isolates were selected from different outbreaks in the Turkish National Reference Laboratory. All isolates were submitted to antimicrobial susceptibility test, plasmid profile analysis, and XbaI-digested pulsed-field gel electrophoresis. Results: The strains were scanned against 20 antibiotics and for 3 of them (amikacin, ciprofloxacin, gentamicin), all strains were found to be sensitive. Five isolates had no plasmid. Most of test strains carried the 57-kb plasmid in …

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Prognostic Value Of Hemostasis-Related Parameters For Prediction Of Organ Dysfunction And Mortality In Sepsis, Dunja Mihajlovic, Dajana Lendak, Gorana Mitic, Tatjana Cebovic, Biljana Draskovic, Aleksandra Novakov, Snezana Brkic Jan 2015

Prognostic Value Of Hemostasis-Related Parameters For Prediction Of Organ Dysfunction And Mortality In Sepsis, Dunja Mihajlovic, Dajana Lendak, Gorana Mitic, Tatjana Cebovic, Biljana Draskovic, Aleksandra Novakov, Snezana Brkic

Turkish Journal of Medical Sciences

Clinical manifestations of sepsis are not caused directly by the invading pathogens, but rather mostly by systemic inflammation that leads to activation of the coagulation system. The aim of this study was to determine whether levels of hemostasis-related parameters measured in intensive care unit admissions are associated with mortality and severity in patients with sepsis. Materials and methods: Eighty-five patients who fulfilled criteria for a diagnosis of sepsis were included in our study. Platelet count, activated partial thromboplastin time (aPTT), prothrombin time (PT), thrombin time, D-dimer, and fibrinogen levels were determined within the first 24 h from sepsis onset. Differences …

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A New Utilization Area For Hyperbaric Oxygen? Improving Quality Of Stored Blood, Hakan Ay, Ramazan Yüksel, Kemal Şi̇mşek, Turgut Topal, Özgür Yeşi̇lyurt, Şükrü Öter, Ahmet Korkmaz, Mehmet Özler, Bülent Uysal, Hali̇l Yaman, Orhan Bedi̇r, Hayati̇ Bi̇lgi̇ç Jan 2015

A New Utilization Area For Hyperbaric Oxygen? Improving Quality Of Stored Blood, Hakan Ay, Ramazan Yüksel, Kemal Şi̇mşek, Turgut Topal, Özgür Yeşi̇lyurt, Şükrü Öter, Ahmet Korkmaz, Mehmet Özler, Bülent Uysal, Hali̇l Yaman, Orhan Bedi̇r, Hayati̇ Bi̇lgi̇ç

Turkish Journal of Medical Sciences

Since blood bags have the ability for diffusion of gases, we investigated whether hyperbaric oxygen (HBO) exposure affects several vital parameters of stored blood. Materials and methods: Bloods obtained from the same persons were used as both control and HBO groups and stored in pediatric bags with citrate-phosphate-dextrose solution. HBO administration was performed at 2.5 atm for 90 min, started 1 day after blood collection and repeated every 2 days for a total of 10 times. The study was terminated on the 21st day. Complete blood count, glucose, pH, and osmotic fragility values were measured every week. Results: Glucose and …

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Serum Vegf Levels In Gastric Cancer Patients: Correlation With Clinicopathological Parameters, Celal İsmai̇l Bi̇lgi̇ç, Mesut Tez Jan 2015

Serum Vegf Levels In Gastric Cancer Patients: Correlation With Clinicopathological Parameters, Celal İsmai̇l Bi̇lgi̇ç, Mesut Tez

Turkish Journal of Medical Sciences

To evaluate the predictive role of the circulating levels of vascular endothelial growth factor (VEGF) in gastric cancer patients. Materials and methods: This study is a case-control study. We measured serum VEGF levels of 30 patients aged between 34 and 83 years with gastric cancer and 30 patients without malignant pathology, operated on for benign pathologies, with ages ranging from 18 to 69. Results: Serum levels of VEGF were correlated with the tumor type classification (signet cell adenocarcinoma) and the presence of adjacent tissue invasion. There was also a positive correlation between serum VEGF and carcinoembryonic antigen levels. Conclusion: In …

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Clinicopathological Importance Of Ki-67, P27, And P53 Expression In Gastric Cancer, Muhammet Çalik, Eli̇f Demi̇rci̇, Eren Altun, İlknur Çalik, Özge Beyza Gündoğdu, Nesri̇n Gürsan, Betül Gündoğdu, Mevlüt Albayrak Jan 2015

Clinicopathological Importance Of Ki-67, P27, And P53 Expression In Gastric Cancer, Muhammet Çalik, Eli̇f Demi̇rci̇, Eren Altun, İlknur Çalik, Özge Beyza Gündoğdu, Nesri̇n Gürsan, Betül Gündoğdu, Mevlüt Albayrak

Turkish Journal of Medical Sciences

To assess the prognostic value of Ki-67, p27, and p53 immunoreactivity in human gastric cancer. Materials and methods: A total of 84 patients with gastric cancer participated in our study. We categorized tumors as intestinal and diffuse types, with reference to Lauren's classification. Ki-67, p27, and p53 immunoreactivity were correlated with patient's age, tumor type, grade, lymph node status, extent of invasion, tumor-node-metastasis (TNM) stage, and survival. Results: Decreased expression of p27 (50% positivity of cells) were determined in 41 (48.8%) and 29 (36.9%) tumor specimens, respectively, and were connected with both the TNM stage (P = 0.007 and P …

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Evaluation Of Autoinflammatory Disease Genes In Nasal Polyposis, Sabri̇ Köseoğlu, Kürşat Murat Özcan, Aykut İki̇nci̇oğullari, Mehmet Ali̇ Çeti̇n, Tali̇h Özdaş, Si̇bel Özdaş, Serdar Ensari̇, Haci Hüseyi̇n Dere Jan 2015

Evaluation Of Autoinflammatory Disease Genes In Nasal Polyposis, Sabri̇ Köseoğlu, Kürşat Murat Özcan, Aykut İki̇nci̇oğullari, Mehmet Ali̇ Çeti̇n, Tali̇h Özdaş, Si̇bel Özdaş, Serdar Ensari̇, Haci Hüseyi̇n Dere

Turkish Journal of Medical Sciences

To investigate cold-induced autoinflammatory syndrome 1 (CIAS1) gene polymorphisms that cause autoinflammatory diseases in patients with nasal polyposis (NP). Materials and methods: The study included 30 patients diagnosed with NP and 30 healthy age-matched individuals as a control group. CIAS1 polymorphisms were assessed by DNA sequence analysis. Patients with nasal polyps and the control group were compared in terms of gene polymorphisms. Each of the 8 polymorphisms of the CIAS1 gene was analyzed separately in the patient group. Results: The most frequently observed polymorphisms in the patient group were c.732G > A in 83%, c.663C > T in 23%, and c.1308C > A …

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Stress-Responsive Factor Regulation In Patients Suffering From Type 2 Diabetes And Myocardial Infarction, Sobia Mushtaq, Tahir Ali, Farhana Altaf, Muhammad Abdullah, Iram Murtaza Jan 2015

Stress-Responsive Factor Regulation In Patients Suffering From Type 2 Diabetes And Myocardial Infarction, Sobia Mushtaq, Tahir Ali, Farhana Altaf, Muhammad Abdullah, Iram Murtaza

Turkish Journal of Medical Sciences

Pro-free radical oxidative stresses, as well as regulatory factors, are believed to be the key players in the development of diabetes and heart-related disorders such as myocardial infarction. The aim of the present study was to highlight the role of oxidative stress-responsive factors (reactive oxygen species [ROS], super oxide dismutase [SOD], and calpain-1) in type 2 diabetes and myocardial infarction. Materials and methods: A total of 100 type 2 diabetes patients with myocardial infarction and 50 normal individuals were selected for this analysis. The levels of ROS and activities of SOD in the serum were determined. Serum calpain-1 expression was …

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Pregnancy-Associated Plasma Protein A And Procalcitonin As Markers Of Myocardial Injury In Patients With Acute Coronary Syndrome, Ayşegül Bayir, Hasan Kara, Aysel Kiyici, Bahadir Öztürk, Abdullah Si̇vri̇kaya, Fi̇kret Akyürek Jan 2015

Pregnancy-Associated Plasma Protein A And Procalcitonin As Markers Of Myocardial Injury In Patients With Acute Coronary Syndrome, Ayşegül Bayir, Hasan Kara, Aysel Kiyici, Bahadir Öztürk, Abdullah Si̇vri̇kaya, Fi̇kret Akyürek

Turkish Journal of Medical Sciences

To evaluate pregnancy-associated plasma protein A (PAPP-A), ischemia-modified albumin (IMA), procalcitonin, and troponin I levels as diagnostic markers of acute coronary syndrome in patients admitted to the emergency department. Materials and methods: The serum PAPP-A, IMA, procalcitonin, and troponin I levels were measured in 100 patients with acute coronary syndrome admitted to the emergency department and 100 healthy control subjects. Results: Patients with acute coronary syndrome had significantly greater mean serum PAPP-A (patients, 10 ± 10 mIU/L; control subjects, 6 ± 10 mIU/L; P =< 0.001), procalcitonin (patients, 2 ± 10 µg/L; control subjects, 0.4 ± 2 µg/L; P =< 0.001), and troponin I levels (patients, 6 ± 8 µg/L; control subjects, 0.2 ± 0.3 µg/L; P =< 0.001) than control subjects. There was no difference in mean IMA levels between patients and control subjects. There were no significant correlations between PAPP-A levels and IMA, procalcitonin, or troponin I levels in patients with acute coronary syndrome. Conclusion: The PAPP-A, procalcitonin, and troponin I levels were increased in patients with acute coronary syndrome. Therefore, elevated PAPP-A and procalcitonin levels, in addition to troponin I levels, may be useful markers of myocardial injury on admission to the emergency department.

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Investigation Of Tnf-Alpha Gene (G308a) And Gstp1 Gene (Ile105val) Polymorphisms In Turkish Patients With Retinopathy Of Prematurity, Mehmet Türe, Meral Yildiz, Mutlu Karkucak, Emi̇ne Tuna Gülten, Deni̇z Siğirli, Ahmet Tuncer Özmen, Tahsi̇n Yakut Jan 2015

Investigation Of Tnf-Alpha Gene (G308a) And Gstp1 Gene (Ile105val) Polymorphisms In Turkish Patients With Retinopathy Of Prematurity, Mehmet Türe, Meral Yildiz, Mutlu Karkucak, Emi̇ne Tuna Gülten, Deni̇z Siğirli, Ahmet Tuncer Özmen, Tahsi̇n Yakut

Turkish Journal of Medical Sciences

Retinopathy of prematurity (ROP) is one of the most frequent causes of blindness in newborn babies. Currently, its etiology is not fully understood. In this study we aimed to investigate the correlation between a patient group with ROP and a control group in terms of the tumor necrosis factor-alpha (TNF-alpha) (G308A) gene and glutathione-S-transferase P1 (GSTP1) (Ile105Val) gene polymorphism. Materials and methods: Sixty-two patients diagnosed with ROP and 58 control subjects were included in this study. For TNF-alpha (G308A) gene and GSTP1 (Ile105Val) gene polymorphisms, the polymerase chain reaction-restriction fragment length polymorphism method was used. In statistical analysis the significance …

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Hypo- And Hypervolemic Edema In Children With Steroid Sensitive Nephrotic Syndrome, Mehmet Aki̇f Büyükavci, Mahmut Çi̇vi̇li̇bal, Murat Elevli̇, Hati̇ce Ni̇lgün Selçuk Duru Jan 2015

Hypo- And Hypervolemic Edema In Children With Steroid Sensitive Nephrotic Syndrome, Mehmet Aki̇f Büyükavci, Mahmut Çi̇vi̇li̇bal, Murat Elevli̇, Hati̇ce Ni̇lgün Selçuk Duru

Turkish Journal of Medical Sciences

The mechanism of edema formation in nephrotic syndrome is still poorly understood. We aimed to evaluate the volume status in children with steroid-sensitive nephrotic syndrome (SSNS) and to emphasize the importance of echocardiography in demonstrating of volume changes. Materials and methods: Thirty-two SSNS patients and 30 healthy children were enrolled in this study. The volume statuses of patients were evaluated by clinical and laboratory features, including fractional sodium excretion (FENa) and distal sodium/potassium exchange (UK/UNa+K ratio). Inferior vena cava collapsibility index (IVCCI), left atrial diameter (LAD), aortic diameter (AD), and left ventricular mass index (LVMI) were measured using conventional echocardiographic …

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The Long-Term Changes In Pain-Related Symptomatology Of Inguinal Hernia Following 2 Different Herniorrhaphy Techniques, Sali̇h Erpulat Özi̇ş, Işin Ünal Çevi̇k, Hati̇m Yahya Uslu, Süleyman Özdemi̇r, Kami̇l Gülpinar, Hasan Turgut Aydin Jan 2015

The Long-Term Changes In Pain-Related Symptomatology Of Inguinal Hernia Following 2 Different Herniorrhaphy Techniques, Sali̇h Erpulat Özi̇ş, Işin Ünal Çevi̇k, Hati̇m Yahya Uslu, Süleyman Özdemi̇r, Kami̇l Gülpinar, Hasan Turgut Aydin

Turkish Journal of Medical Sciences

To compare the changes in pain-related symptoms of inguinal hernias from initial admission to postoperative month 6 following 2 herniorrhaphy techniques. Materials and methods: Patients with unilateral inguinal hernias were scheduled for either Lichtenstein or self-gripping polypropylene mesh repair. Patients were preoperatively evaluated with a visual analog scale (VAS) and a Turkish version of the Douleur Neuropathique 4 (DN4) questionnaire and the complaints related to pain were noted. After surgery, patients were discharged without early complications. Patients were reassessed at postoperative month 6. The late-term complaints of pain as well as neurological findings were evaluated using the VAS and the …

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Structural Chromosomal Abnormalities In Couples With Recurrent Abortion In Egypt, Nagwa E.A. Gaboon, Ahmed Ramy Mohamed, Solaf M. Elsayed, Osama K. Zaki, Mohamed A. Elsayed Jan 2015

Structural Chromosomal Abnormalities In Couples With Recurrent Abortion In Egypt, Nagwa E.A. Gaboon, Ahmed Ramy Mohamed, Solaf M. Elsayed, Osama K. Zaki, Mohamed A. Elsayed

Turkish Journal of Medical Sciences

To evaluate the incidence of chromosomal abnormalities in couples who experience recurrent abortion and identify additional factors that may be predictive of abortion, such as parental age and unfavorable obstetric or abnormal semen analysis. Materials and methods: The present study examined 125 couples who had experienced recurrent abortion. All subjects provided a detailed personal medical history and ancestral history and underwent a physical examination. Women in the study group underwent biochemical testing and pelvic ultrasound examinations, and men underwent a semen analysis. Results: Among the 125 couples tested, 8 couples (6.4%) displayed a balanced translocation, among which 7 (5.6%) showed …

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Aberrant Expression Of Leukemia Inhibitory Factor Receptor (Lifr) And Leukemia Inhibitory Factor (Lif) Is Associated With Tubal Pregnancy Occurrence, Yong Li, Lizhou Sun, Denmei Zhao, Jun Ouyang, Mei Xiang Jan 2015

Aberrant Expression Of Leukemia Inhibitory Factor Receptor (Lifr) And Leukemia Inhibitory Factor (Lif) Is Associated With Tubal Pregnancy Occurrence, Yong Li, Lizhou Sun, Denmei Zhao, Jun Ouyang, Mei Xiang

Turkish Journal of Medical Sciences

Tubal pregnancy is a major cause of maternal death in the first trimester and exploration of its underlying molecular mechanism is of great importance. This study aimed to explore the association of tubal pregnancy with leukemia inhibitory factor (LIF) and leukemia inhibitory factor receptor (LIFR) expression in oviduct tissues. Materials and methods: Immunohistochemistry was performed to probe the differential expression of LIF and LIFR in oviduct tissues among a control group (including NP group, n = 11; and IP group, n = 12), tubal pregnancy group (Ect-N group, n = 31; and Ect-A group, n = 40), and chronically inflamed …

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The Effect Of Extracorporeal Shock Wave Lithotripsy On Distribution Of Interstitial Cells Of Cajal In Rabbit Renal Pelvis And Proximal Ureter, Özlem Boybeyi̇, Mi̇ne Fedakar Şenyücel, Ebru Şebnem Ayva, Tutku Soyer, Mustafa Kemal Aslan, Mehmet Murad Başar, Ahmet Murat Çakmak Jan 2015

The Effect Of Extracorporeal Shock Wave Lithotripsy On Distribution Of Interstitial Cells Of Cajal In Rabbit Renal Pelvis And Proximal Ureter, Özlem Boybeyi̇, Mi̇ne Fedakar Şenyücel, Ebru Şebnem Ayva, Tutku Soyer, Mustafa Kemal Aslan, Mehmet Murad Başar, Ahmet Murat Çakmak

Turkish Journal of Medical Sciences

An experimental study was performed to evaluate the effect of extracorporeal shock wave lithotripsy (ESWL) on the distribution of interstitial cells of Cajal (ICC) in rabbit renal pelvis and proximal ureter. Materials and methods: Six New Zealand rabbits were included. Right kidneys were exposed to a total of 3000 shock waves (14 kV) by using an electrohydraulic-type ESWL device. Right sides were allocated as the ESWL group (EG, n = 6) and left sides as the control group (CG, n = 6). Tissues were harvested on day 7. Tissues were examined histopathologically for the presence of edema, inflammation, congestion, hemorrhage, …

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Is There An Association Between Histopathological Changes In The Lower Ureter And Renal Functions? Evaluation Of Patients Who Underwent Ureteroneocystostomy For Ureterovesical Obstruction Or Vesicoureteral Reflux, Müjdem Nur Azili, Doğuş Güney, Ayper Kaçar, Hüseyi̇n Tuğrul Ti̇ryaki̇ Jan 2015

Is There An Association Between Histopathological Changes In The Lower Ureter And Renal Functions? Evaluation Of Patients Who Underwent Ureteroneocystostomy For Ureterovesical Obstruction Or Vesicoureteral Reflux, Müjdem Nur Azili, Doğuş Güney, Ayper Kaçar, Hüseyi̇n Tuğrul Ti̇ryaki̇

Turkish Journal of Medical Sciences

We aimed to assess the relationship between the histological changes of the ureterovesical junction (UVJ) and renal functions. Therefore, we evaluated histological changes of the lower ureter and renal scintigraphy findings of patients for whom ureteroneocystostomy was performed because of vesicoureteral reflux (VUR) or ureterovesical junction obstruction (UVO). Materials and methods: UVJ specimens were obtained from 18 children. We investigated the changes in neuronal innervation, muscular morphology, extracellular matrix, and apoptosis rate with renal scintigraphy findings. Results: Seven UVO and 11 VUR patients were treated. Alpha-actin expression in smooth muscle cells was found to be lower (P < 0.001) while neuronal defect was more prominent in the UVO group (P = 0.002). The renal functions decreased as the smooth muscle structural defect increased in the VUR group (P < 0.05). Conclusion: Neuronal tissue and muscle tissue were more defective in the UVO group. The decrease in neuronal fibers and muscle cells explains the pathogenesis of the obstructive group, but no difference was observed regarding the accumulation of collagen type 3 and cellular apoptosis between the VUR and UVO groups. In the VUR group, renal functions decreased while the smooth muscle defect at the distal end of the ureter increased.

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Comparison Of Perioperative Oxidative Stress In Endovascular And Open Repair Of Abdominal Aortic Aneurysm, Orhan Veli̇ Doğan, Ümi̇t Menteşe, Süheyla Doğan, Sefer Usta, İbrahi̇m Turan, Ergün Hali̇loğlu, Süleyman Caner Karahan Jan 2015

Comparison Of Perioperative Oxidative Stress In Endovascular And Open Repair Of Abdominal Aortic Aneurysm, Orhan Veli̇ Doğan, Ümi̇t Menteşe, Süheyla Doğan, Sefer Usta, İbrahi̇m Turan, Ergün Hali̇loğlu, Süleyman Caner Karahan

Turkish Journal of Medical Sciences

To investigate the differences in perioperative oxidative stress (OS) in abdominal aortic aneurysm (AAA) patients treated with either endovascular repair (EVAR) or open repair (OR). Materials and methods: Twenty patients (11 OR, 9 EVAR) treated for AAA with no known malignant or inflammatory disease and an aneurysm diameter of over 5 cm and no rupture were included in the study. Blood samples were obtained preoperatively, during aortic occlusion, and 1 h and 24 h after reperfusion. Total antioxidant status (TAS), total oxidative stress (TOS), and malondialdehyde (MDA) levels were measured and oxidative stress index (OSI) was calculated. Results: OSI at …

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