Medicine and Health Sciences Commons^™

Integrating Basic Research With Prevention/Intervention To Reduce Risky Substance Use Among College Students, Danielle M. Dick, Linda C. Hancock

Psychiatry Publications

Too often basic research on etiological processes that contribute to substance use outcomes is disconnected from efforts to develop prevention and intervention programming. Substance use on college campuses is an area of concern where translational efforts that bring together basic scientists and prevention/intervention practitioners have potential for high impact. We describe an effort at a large, public, urban university in the United States to bring together researchers across the campus with expertise in college behavioral health with university administration and health/wellness practitioners to address college student substance use and mental health. The project “Spit for Science” examines how genetic and …

Altered Protease And Antiprotease Balance During A Copd Exacerbation Contributes To Mucus Obstruction, Shashi Chillappagari, Jenni Preuss, Sebastian Licht, Christian Müller, Poornima Mahavadi, Gaurav Sarode, Claus Vogelmeier, Andreas Guenther, Lutz Narlich, Bruce K. Rubin, Markus O. Henke

Pediatrics Publications

Background

Proteases have been shown to degrade airway mucin proteins and to damage the epithelium impairing mucociliary clearance. There are increased proteases in the COPD airway but changes in protease-antiprotease balance and mucin degradation have not been investigated during the course of a COPD exacerbation. We hypothesized that increased protease levels would lead to mucin degradation in acute COPD exacerbations.

Methods

We measured neutrophil elastase (NE) and alpha 1 protease inhibitor (A1-PI) levels using immunoblotting, and conducted protease inhibitor studies, zymograms, elastin substrate assays and cigarette smoke condensate experiments to evaluate the stability of the gel-forming mucins, MUC5AC and MUC5B, …

Variability In Splanchnic Tissue Oxygenation During Preterm Red Blood Cell Transfusion Given For Symptomatic Anaemia May Reveal A Potential Mechanism Of Transfusion-Related Acute Gut Injury, Sean M. Bailey, Karen D. Hendricks-Muñoz, Pradeep V. Mally

Pediatrics Publications

Background

There is increasing evidence indicating an association between red blood cell (RBC) transfusions and necrotising enterocolitis (NEC) in preterm infants, especially late-onset NEC. This phenomenon is referred to as transfusion-related acute gut injury (TRAGI). One theory as to a pathophysiological mechanism is that transfusion may result in an ischemia-reperfusion injury to intestinal tissue. We tested the hypothesis that there is significantly greater variability during transfusion in splanchnic tissue oxygen saturation (SrSO2) than in cerebral tissue oxygen saturation (CrSO2).

Materials and methods

This was a prospective, observational study using near-infrared spectroscopy to monitor SrSO2 and CrSO2in preterm neonates undergoing RBC …

Stress Reactivity To An Electronic Version Of The Trier Social Stress Test: A Pilot Study, Sage E. Hawn, Lisa Paul, Suzanne Thomas, Stephanie Miller, Ananda B. Amstadter

Psychiatry Publications

Social stressors that rely on the inclusion of confederates (i.e., Trier Social Stress Test, TSST) are often used in clinical laboratory research paradigms to elicit a measurable stress response in participants. Although effective, the TSST is labor intensive and may introduce error variance as a function of confederate race, gender, and/or response characteristics. The present study aimed to develop and validate an electronic version of the TSST (e-TSST). The primary aim was to compare the e-TSST to an e-neutral control condition; the exploratory aim was to compare the magnitude of stress response elicited by the e-TSST to that elicited by …

Distmix: Direct Imputation Of Summary Statistics For Unmeasured Snps From Mixed Ethnicity Cohorts, Donghyun Lee, T. Bernard Bigdeli, Vernell S. Williamson, Vladimir I. Vladimirov, Brien P. Riley, Ayman H. Fanous, Silviu-Alin Bacanu

Psychiatry Publications

Motivation: To increase the signal resolution for large-scale meta-analyses of genome-wide association studies, genotypes at unmeasured single nucleotide polymorphisms (SNPs) are commonly imputed using large multi-ethnic reference panels. However, the ever increasing size and ethnic diversity of both reference panels and cohorts makes genotype imputation computationally challenging for moderately sized computer clusters. Moreover, genotype imputation requires subject-level genetic data, which unlike summary statistics provided by virtually all studies, is not publicly available. While there are much less demanding methods which avoid the genotype imputation step by directly imputing SNP statistics, e.g. Directly Imputing summary STatistics (DIST) proposed …

Stress Reactivity To An Electronic Version Of The Trier Social Stress Test: A Pilot Study, Sage E. Hawn, Lisa Paul, Suzanne Thomas, Stephanie Miller, Ananda B. Amstadler

Psychiatry Publications

Social stressors that rely on the inclusion of confederates (i.e., Trier Social Stress Test, TSST) are often used in clinical laboratory research paradigms to elicit a measurable stress response in participants. Although effective, the TSST is labor intensive and may introduce error variance as a function of confederate race, gender, and/or response characteristics. The present study aimed to develop and validate an electronic version of the TSST (e-TSST). The primary aim was to compare the e-TSST to an e-neutral control condition; the exploratory aim was to compare the magnitude of stress response elicited by the e-TSST to that elicited by …

Genetic Network Properties Of The Human Cortex Based On Regional Thickness And Surface Area Measures, Anna R. Docherty, Chelsea K. Sawyers, Matthew S. Panizzon, Michael C. Neale, Lisa T. Eyler, Christine Fennema-Notestine, Carol E. Franz, Chi-Hua Chen, Linda K. Mcevoy, Brad Verhulst, Ming T. Tsuang, William S. Kremen

Psychiatry Publications

We examined network properties of genetic covariance between average cortical thickness (CT) and surface area (SA) within genetically-identified cortical parcellations that we previously derived from human cortical genetic maps using vertex-wise fuzzy clustering analysis with high spatial resolution. There were 24 hierarchical parcellations based on vertex-wise CT and 24 based on vertex-wise SA expansion/contraction; in both cases the 12 parcellations per hemisphere were largely symmetrical. We utilized three techniques—biometrical genetic modeling, cluster analysis, and graph theory—to examine genetic relationships and network properties within and between the 48 parcellation measures. Biometrical modeling indicated significant shared genetic covariance between size of several …

Soft, Curved Electrode Systems Capable Of Integration On The Auricle As A Persistent Brain–Computer Interface, James J. S. Norton, Dong Sup Lee, Jung Woo Lee, Woosik Lee, Ohjin Kwon, Philip Won, Sung-Young Jung, Huanyu Cheng, Jae-Woong Jeong, Abdullah Akce, Stephen Umunna, Ilyoun Na, Yong Ho Kwon, Xiao-Qi Wang, Zhuangjian Liu, Ungyu Paik, Yonggang Huang, Timothy Bretl, Woon-Hong Yeo, John A. Rogers

Mechanical and Nuclear Engineering Publications

Recent advances in electrodes for noninvasive recording of electroencephalograms expand opportunities collecting such data for diagnosis of neurological disorders and brain–computer interfaces. Existing technologies, however, cannot be used effectively in continuous, uninterrupted modes for more than a few days due to irritation and irreversible degradation in the electrical and mechanical properties of the skin interface. Here we introduce a soft, foldable collection of electrodes in open, fractal mesh geometries that can mount directly and chronically on the complex surface topology of the auricle and the mastoid, to provide high-fidelity and long-term capture of electroencephalograms in ways that avoid any significant …

Stability Of Lidocaine Tested By Forced Degradation And Its Interactions With Serum Albumin, Lindsay Nichols

STAR Program Research Presentations

A concern for future long-term manned space expeditions is the ability to treat illnesses with appropriate pharmaceuticals. However, pharmaceuticals degrade faster in space than on Earth presumably due to an abundance of space radiation. The stability of Lidocaine was investigated because it is a common pain reliever currently used on the International Space Station. One of the most common proteins in blood is serum albumin, which acts as a carrier to distribute drugs throughout the body. It is important to know how well the drug binds to serum albumin so that the rate of distribution of Lidocaine-bound protein in blood …

Detection Of Catecholamines Produced In Planktonic P. Aeruginosa And S. Aureus Treated With Adult Bovine Serum, Jorge A. Serrano, Anil Serrano, Shaleni Singh, Jaime Fuentes, Robert Crawford Dr., Rivkah Isseroff, Thomas Peavy

STAR Program Research Presentations

Bacterial biofilms play a critical role in inducing and sustaining chronic wounds that are serious health threats. Bacterial biofilms can also be found on medical prosthetics and implants that sustain infections in patients and cause life threatening situations. Bacteria self-produce these sticky extracellular substances termed a biofilm which help them to adhere to each other forming a community of microorganisms. One of the major issues is that biofilms have antimicrobial characteristics and provide protection from the immune system; biofilms are found in over 80% of human bacterial infections. Formation of a bacterial biofilm occurs when an individual (planktonic) bacterial cell …

Treatment And Prevention Of Injuries: Content Analysis Running Magazines, Haley C. Russell, Emily J. Houghton

Human Performance Department Publications

Runners often self-diagnose and treat injuries (Russell & Wiese-Bjornstal, under review), and report beliefs about injuries unsubstantiated by research (Saragiotto et al., 2014a). Scheufele and Tewskbury (2007) suggest the way media sources frame a story can influence consumers’ interpretation, for example, what runners read in magazines can influence their beliefs about injury. This study’s purpose was to determine what running magazines present as strategies for injury prevention and treatment. Results of a content analysis revealed summaries of research and advice from coaches as the most common sources of evidence. The most frequent prevention and treatment strategy was stretching. Rarely were …

Development And Reliability Testing Of A Survey: Measuring Trusting And Deference Behaviors In Microethical Nursing Practice, Lorretta Krautscheid, Justin Britton, Carol Craig

Faculty Publications - College of Nursing

Novice post-licensure nurses are frequently exposed to microethical nursing practice problems during their first 24 months of formative practice. Often, novice nurses trust the advice of experienced nurse coworkers, deferring to such advice even when they know the advice contradicts evidence-based practice. This study revealed the prevalence of deference behaviors and associated rationale. Study findings emphasize the importance of incorporating conflict management, effective communication techniques, ethical frameworks, and EBP standards within pre- and post-licensure education.

Front Matter, Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

Faculty And Mid-Level Providers, Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

Fellows, Chiefs And Residents, Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

Physical Therapy Faculty, Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

Division Of Research, Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

Letter From The Chief Of The Division Of Physical Therapy, Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

Severely Deformed Extraarticular Fractures Of The Scapula: A Review, Sean B. Kuehn

UNM Orthopaedic Research Journal

Nonoperative treatment of severely deformed fractures of the scapula was historically common. However, the findings of newer research have challenged the notion that conservatively managing these fractures results in the most successful outcomes. In an attempt to possibly reveal important indicators for surgical treatment, I reviewed studies on scapula fractures involving scapular anatomy; associated injuries; technological advances that have helped with fracture evaluation; and treatment outcomes between nonsurgical and surgical methods. Although a universally accepted classification scheme of scapula fractures does not exist, use of 3D reconstruction with computed tomography can help define the level and category of fracture deformity. …

Learning The Laprade Technique For Reconstruction Of The Posterolateral Corner Of The Knee, Dustin L. Richter

UNM Orthopaedic Research Journal

No abstract provided.

Treatment Of Full Circumferential Segmental Bone Loss Of The Tibia Resulting From Acute Traumatic Injuries And Complications: A Review, Gregory C. Strohmeyer

UNM Orthopaedic Research Journal

Full circumferential segmental bone loss of the tibia presents a challenge to orthopaedic surgeons. These open fractures often involve extensive soft-tissue damage, which can contribute to poor long-term outcomes even if the tibia is successfully reconstructed. Although amputation was historically used to treat full circumferential segmental bone loss of the tibia because of the severity of the injury, the development of new reconstruction procedures has provided the option of limb salvage techniques. I reviewed studies on treatment of traumatic tibia bone loss, focusing particularly on full circumferential bone loss of greater than 3 cm. Treatment options included amputation, allograft replacement, …

Open Reduction And Internal Fixation For Treatment Of Proximal Humerus Fractures: A Review, Heather K. Woodin

UNM Orthopaedic Research Journal

Fractures of the proximal humerus are common in older patients, and the incidence of these fractures in the United States is expected to notably increase with the aging population. Nonoperative procedures have been preferred in elderly patients with stable fracture patterns to avoid complications associated with osteoporotic bone. However, more complex and unstable fracture patterns often necessitate operative techniques to allow for more anatomical healing. Although proximal humerus fractures have been thoroughly examined, systemized, and studied, no clear method to choosing an appropriate surgical treatment or candidate has been accepted. I reviewed the role of the following factors on successful …

Third Extensor Compartment Disruption And The Biomechanics Of Thumb Extension, Christina Salas, Drew K. Newhoff, Zainab Cheema, Allison A. Richards, Deana M. Mercer, Amanda K. Medoro, Ahmed M. Afifi, Moheb S. Moneim, John M. Veitch

UNM Orthopaedic Research Journal

Background: Procedures involving release of the third dorsal wrist compartment have been thought to transpose the extensor pollicis longus (EPL) tendon from its anatomical position. Few studies, however, have reported on the effects this might have on function and mechanics of the thumb. We analyzed the impacts of intact extensor retinaculum, release of the third dorsal compartment, and removal of Lister’s tubercle on thumb extension.

Methods: A total of 15 fresh-frozen cadaveric upper extremities (eight male, seven female; mean age, 52 years; range, 38-59 years) were used. For each specimen, three phases of testing were analyzed: the extensor retinaculum was …

Nonunion After Hybrid Plating With Locking And Nonlocking Screws In Radius And Ulna Shaft Fractures: Report Of Two Cases, Zainab Cheema, Nathan E. Huff, Deana M. Mercer

UNM Orthopaedic Research Journal

Conventional compression plating has been found effective in treating forearm diaphyseal fractures, providing stability as well as resistance to axial, torsional, and bending forces. Locked plating has provided stability without frictional force between the bone-plate interface, which may help preserve periosteal blood supply, and is useful in treating metaphyseal, comminuted, and osteoporotic fractures. Hybrid plating has been used in an attempt to combine the strengths of these two techniques; however, in the context of simple forearm diaphyseal fractures with healthy bone, its effectiveness is only theoretical. We describe two patients in whom open reduction and internal fixation with hybrid plating …

Isolated Traumatic Subscapularis Tear In A 12-Year-Old Male Gymnast: A Case Report, Katherine J. Gavin, Gehron P. Treme

UNM Orthopaedic Research Journal

Isolated avulsion fractures of the lesser tuberosity are rarely encountered in younger and older populations. However, because the tendon of the subscapularis insertion is stronger in skeletally immature individuals, isolated tears to the tendon occur more commonly in adults than children and adolescents. Most studies have been limited to case reports that mainly describe traumatic subscapularis tears in adolescent athlete-patients. We present a 12-year-old male gymnast who reported to our clinic with pain and weakness in the right shoulder at 2 months after the initial injury. We performed open repair with suture anchor fixation for treatment of an isolated subscapularis …

Carpal Tunnel Syndrome Associated With A Palmaris Profundus Tendon: A Case Report, Andrea B. Lese, Kristin M. Loker, Moheb S. Moneim

UNM Orthopaedic Research Journal

Carpal tunnel syndrome (CTS) is often found in adults and may be associated with rare anatomical abnormalities in the hand, such as the presence of a palmaris profundus tendon. Although the muscle was originally thought to be a variant of the palmaris longus muscle, some case studies have described both structures during operative treatment with open carpal tunnel release. We present a case of a 51-year-old woman who underwent open carpal tunnel release to treat CTS of the right hand. Preoperatively, results of electrodiagnostic tests and clinical examinations, respectively, were normal and equivocal. Intraoperatively, a palmaris profundus tendon was found …

Severe Ischemia Of The Finger After Use Of Compressive Self-Adherent Wrap: Report Of Two Cases, Andrea B. Lese, Elizabeth A. Mikola, Deana M. Mercer

UNM Orthopaedic Research Journal

Use of Coban compressive self-adherent wraps (3M, St Paul, MN) has been found helpful in treating various conditions and injuries of the extremities, including lymphedema, edema in burned hands, and sprains or strains. However, the availability and easy application of the wrap have resulted in its common usage with or without adequate instructions. We report two cases in which severe pain and ischemia developed after this bandage was circumferentially applied to a finger to stop bleeding from a simple laceration. One patient required amputation at the level of the proximal interphalangeal joint; the other had resolution of venous congestion symptoms …

Surgical Treatment Of Chronic Dislocation Of A Posterior Tibial Tendon In A Collegiate Athlete: A Case Report, Tony G. Pedri, Richard A. Miller

UNM Orthopaedic Research Journal

Traumatic dislocation of the posterior tibial tendon (PTT) is a rare and often misdiagnosed injury. The limited number of cases, ambiguous results of initial imaging studies, and presence of symptoms similar to medial ankle sprains can contribute to unsuccessful long-term treatment. Current studies, although limited, report high rates of failure in nonoperative compared with operative treatment. We describe a 21-year-old male baseball player who experienced pain and mild swelling in his ankle after falling while running at full speed. After 5 months of continuous pain in the medial ankle, the patient was referred to our clinic and underwent suture anchor …

Unicameral Bone Cyst Of The Pelvis In A 13-Yearold Boy Treated With Cannulated Screw Decompression After Open Curettage And Grafting: A Case Report, Reilly J. Kuehn, David H. Chafey

UNM Orthopaedic Research Journal

Although studied for more than a century, the cause of unicameral bone cyst (UBC) remains uncertain. UBC of the pelvis in younger patients has been particularly problematic because its rarity often results in misdiagnosis and improper treatment. Surgical treatment has typically involved percutaneous or open curettage and bone grafting; however, some studies have described the use of a continuous decompression device to address high recurrence rates of the lesion. We present a 13-year-old male patient in whom, after two unsuccessful operations, open curettage and grafting and insertion of a cannulated screw led to resolution of pain caused by a large, …

Scaphoid Stress Fracture In A 65-Year-Old Man With Low Bone Mineral Density: A Case Report, Dean W. Smith

UNM Orthopaedic Research Journal

Although commonly reported in women and less commonly in younger athletes, no studies have reported stress fractures of the scaphoid in older, sedentary men. Because of its rarity, osteoporosis in older men is often unrecognized and only diagnosed after the fracture. I describe a previously sedentary 65-year-old man who presented to my clinic with pain in the right wrist after his first day of intense physical activity and underwent 8 weeks of splinting and bracing for treatment of a fracture of the waist of the scaphoid. Ten weeks after the pain began, a computed tomography image revealed healing of the …