Medicine and Health Sciences Commons^™

Under Recognized Entity: Chronic Inflammatory Demyelinating Polyneuropathy With Lupus, Ali Zohair Nomani, Haris Majid Rajput, Rao Sohail Yasin Khan, Mansoor Iqbal, Zakir Jan, Uzma Jamil, Mazhar Badshah, Muhammad Irshad

Pakistan Journal of Neurological Sciences (PJNS)

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an acquired, autoimmune peripheral neuropathy. It has an insidious disease progression resulting in a debilitating illness. It is a well known neurological disorder. The causative factors are elucidating and it is generally considered idiopathic. However, its’ associations with various systemic disorders is well established albeit under recognized, especially with lupus as evident by few of the case reports/ series published in the recent past. The aim of this report is to highlight this neglected but important aspect of clinical neurology in common practice.

Eight – And - Half Syndrome: A Rare Neuro-Ophthalmic Syndrome “Possible Nine Syndrome”, Muslim Ali Lakhiar, Shaheen Ahmed Mughal

Pakistan Journal of Neurological Sciences (PJNS)

“Eight-and-half” syndrome is “one-and-a-half” syndrome characterized by conjugated horizontal gaze palsy and internuclearopthalmoplegia plus ipsilateral fascicular seventh nerve palsy. We report a case of 50 year old woman who presented with right eight and half syndrome together with contralateral hemiparesis and hemihypesthesia. Non contrast CT scan brain showed hyperdensesignal on right pontine region. MRI brain plain revealed hemorrhagicpontinetegmentuminfarction as well as corticospinal tract and medial meniscus. This spectrum of presentation suggests a possible “Nine syndrome” as a novel neuropthalmicpontine syndrome. The first of its kind ever reported from Pakistan

A 2 ½ Years Old Boy With Squint And Speech Loss, Shaila Ali, Zia Ur Rehman, Tipu Sultan

Pakistan Journal of Neurological Sciences (PJNS)

Tuberculosis of central nervous system is not uncommon in children of developing countries. Tuberculomaswere initially misdiagnosed due to lack of radiological expertise, un availability of CT scans and MRI. For early diagnosis and treatment, they should be kept in differential of space occupying lesions.We had a 2 ½ years old patient had fever, squint, aphasia and loss of motor milestones. On examination he was a malnourished child with right sided hypertonia and involvement of 9th and 10th cranial nerves with hepatospleenomegaly. His CRP was raised and CXRshowed B/L milliary shadowing which helped us to find out the primary focus leading …

Spectrum Of Neuromuscular Injuries In Victims Of Bomb Blasts, Dureshahwar Kanwar, Ambreen Iqrar, Zaitoon Shivji, Sara Khan

Pakistan Journal of Neurological Sciences (PJNS)

Introduction:
Bomb blast (BB) injuries outside war zones were a rare phenomenon until recently. With the spreading wave of terrorism across the globe, BB related trauma is resurfacing. Explosions can produce unique patterns of neuromuscular injury. No recent data exists categorizing such injuries.

Methods:
Medical records and electrodiagnostic findings of 20 patients with BB related neuromuscular injuries (NMI) were reviewed retrospectively.

Results:
Most common site of injury was the lower extremities (55%) with majority presenting clinically with foot drop (40%) or weakness (30%). 9/17 patients (45%) had associated shrapnel or penetrating trauma. 6/20 patients had associated fractures. The most …

An Ode To Neurology, Marina Wazir

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

National Guidelines For Diagnosis And Management Of Parkinson’S Disease In Pakistan, Nadir A Syed, Farwa Ali, Khalid Sher, Amer Ikram, Bashir Soomro, Naila Shahbaz, Mughis Sheerani, Sarwar Jamil, Ahsan Numan, Manzoor Lakhair, Irshad Awan, Saleem Barech, Haroon Basheer

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

ระบบคุณภาพสำหรับการให้บริการทางห้องปฏิบัติการ ณ จุดดูแลผู้ป่วย, ยุวรีย์ พิชิตโชค

Chulalongkorn Medical Journal

การตรวจทางห้องปฏิบัติการ ณ จุดดูแลผู้ป่วย (POCT) ทำให้เพิ่มประสิทธิภาพในการดูแลรักษา การตรวจวิเคราะห์นอกห้องปฏิบัติการดังกล่าวยังต้องให้ความสำคัญ และคำนึงถึงระบบคุณภาพที่เน้นความถูกต้อง แม่นยำ ของการตรวจวิเคราะห์ดังกล่าวด้วย เนื่องจากการใช้ POCT ที่ไม่ได้มีระบบคุณภาพรองรับอาจส่งผลต่อความปลอดภัยในการดูแลผู้ป่วยได้ ความผิดพลาดในการวิเคราะห์อาจเกิดได้ทั้งในขั้นตอน pre-analytic, analytic และ post-analytic มาตรฐานในระดับสากลที่นำมาใช้รับรองคุณภาพของ POCT คือ มาตรฐาน ISO 22870:2006 ซึ่งประกอบด้วยข้อกำหนดด้านการบริหารจัดการ 14 ข้อ และข้อกำหนดด้านวิชาการ 8 ข้อ ซึ่งมาตรฐานการดังกล่าวเพื่อให้สามารถตรวจวิเคราะห์ POCT ได้อย่างถูกต้องปลอดภัย เพื่อเพิ่มคุณภาพการบริการผู้ป่วย.

Factors Affecting Decision Making Of New Graduate Physicians In Choosing Potential Areas Of Practice: A National Survey, Jate Ratanachina, Seelwan Sathitratanacheewin, Sirawit Kollawat, Kittithat Tantitanawat, Krit Pongpirul

Chulalongkorn Medical Journal

Background : In equitable distribution of physicians is a challenge especially in rural areas of developing countries including Thailand. The resignations of newly graduated physicians imply a failure of in comprehensive policy interventions that are not based on real and holistic understanding of the issue. Objective : This study was aimed to empirically explore factors influencing decision making of newly graduated physicians in choosing future practice areas. Design : Descriptive statistics and exploratory factor analysis (EFA) were used for analyzing the responses. Setting : Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University Methods : A national survey …

การใช้ Breast Mri ในการตรวจคัดกรองโรคมะเร็งเต้านม, อภินัทธ์ วงศ์เกียรติขจร, กษยา ตันติผลาชีวะ

Chulalongkorn Medical Journal

โรคมะเร็งเต้านมเป็นมะเร็งที่พบบ่อยเป็นอันดับหนึ่งในสตรีทั่วโลก การตรวจคัดกรองที่ดีขึ้นสามารถลดอัตราการตายได้ ปัญหาการตรวจคัดกรองมะเร็งเต้านมของประเทศไทยในปัจจุบัน คือแบบประเมินความเสี่ยงต่าง ๆ ถูกสร้างจากฐานข้อมูลประชากรผิวขาว ทำให้ไม่มีประสิทธิภาพกับประชากรเอเชีย และปัญหาเทคโนโลยีภาพถ่ายรังสีเต้านมมีข้อจำกัด ในประชากรไทยการนำ breastMRI มาใช้สามารถลดข้อจำกัดการตรวจคัดกรองในปัจจุบันได้ แต่ breast MRI มีข้อเสียเนื่องจากราคาสูงและเกิด false positive ได้ง่าย ดังนั้นจึงควรมีมาตรการการคัดเลือกผู้ที่มีความจำเป็นที่ดีจึงจะเกิดประโยชน์สูงสุด.

Patterns And Predictors Of Local Health Department Accreditation In Missouri, Kate E. Beatty, Jeffrey Mayer, Michael Elliott, Ross C. Brownson, Safina Abdulloeva, Kathleen Wojciehowski

ETSU Faculty Works

Background: The Healthy People 2020 goal for the public health system is “to ensure that Federal, State, Tribal, and local health agencies have the necessary infrastructure to effectively provide essential public health services.” To address this goal, Missouri established the first statewide, voluntary accreditation program of local health departments (LHDs) and began accrediting the LHDs in 2003. The purpose of this study was to identify organizational, structural, and workforce factors related to accreditation status of LHDs in Missouri.

Methods: Using data from the National Association of County & City Health Officials (2010) and the Missouri Department of Health …

State Law Mandates For Reporting Of Healthcare-Associated Clostridium Difficile Infections In Hospitals., Julie Reagan, Carolyn T A Herzig, Monika Pogorzelska-Maziarz, Andrew W Dick, Patricia W Stone, Jd Divya Srinath

Department of Nursing papers and presentations

US state and territorial laws were reviewed to identify Clostridium difficile infection reporting mandates. Twenty states require reporting either under state law or by incorporating federal Centers for Medicare & Medicaid Services' reporting requirements. Although state law mandates are more common, the incorporation of federal reporting requirements has been increasing.

External Validity Of Grammatical Word Category Classification Using An Adaptation And Selection Model, Michelle Chatterton

Theses and Dissertations

The process of acquiring language requires children to learn grammatical categories and apply these categories to new words. Researchers have proposed various explanations of this process in the form of algorithms and computational modeling. Recently, adaptation and selection models have been tested and applied as a possible explanation to the process of acquiring grammatical categories. These studies have proven promising, however, the external validity of this approach has not been examined by grammatically coding samples outside the training corpus. The current thesis applies an adaptation and selection model, which pauses the evolution of dictionaries after every thousand cycles to allow …

Modeling Children's Acquisition Of Grammatical Word Categories From Adult Input Using An Adaptation And Selection Algorithm, Nicole Adele Stenquist

Theses and Dissertations

It is understood that children learn the use of grammatical categories in their native language, and previous models have only been partially successful in describing this acquisition. The present study uses an adaptation selection algorithm to continue the work in addressing this question. The input for the computer model is child-directed speech towards three children, ages ranging from 1;1 to 5;1 during the course of sampling. The output of the model consists of the input words labeled with a grammatical category. This output data was evaluated at regular intervals through its ability to correctly identify the grammatical categories of language …

Editorial, Raj Manchanda

Indian Journal of Research in Homoeopathy

No abstract provided.

Homoeopathic Drug Proving: Randomised Double-Blind Placebo-Controlled Trial, Central Council For Research In Homoeopathy Ccrh

Indian Journal of Research in Homoeopathy

Background: The methodology of Drug Proving has evolved considerably since the times of Dr. Hahnemann. Standardisation of a proving process and quality of proving studies has been a major consideration for research over the years. Proving guidelines have been developed by various international bodies such as Homoeopathic Pharmacopoeia Committee of United States (HPCUS), European Commission of Homoeopathy (ECH) and Liga Medicorum Homoeopathica Internationalis (LMHI). Drug proving has been a major research activity of the Central Council for Research in Homoeopathy (CCRH). CCRH had over the years devised its own methodology for drug proving. A protocol for the drug proving program …

An Investigation To Evaluate The Analgesic And Central Nervous System Depressant Activities Of Solanum Nigrum (Linn.) In Homoeopathic Potencies In Experimental Animal Models, Echur Sundaram, Kushal Singh, Pratap Reddy, Kainikkara Raven Nair, Anil Khurana, Hari Singh, Chaturbhuja Nayak

Indian Journal of Research in Homoeopathy

Background and Objective: In Homoeopathy, Solanum nigrum is clinically used in the treatment of ergotism, meningitis, irritation during dentition and some of the symptoms of neurological disorders but its Central Nervous System (CNS) potential has not been explored experimentally yet. Therefore, a preliminary study was conducted with an objective to evaluate the analgesic and CNS depressant effects of homoeopathic potencies of S. nigrum in experimental animal models. Materials and Methods: The study was conducted in Wistar albino rats using a hot plate, ice plate and Randall-Selitto assay for analgesic; rota-rod and open field test for CNS depressant activities. The different …

Clinical Trial For Evaluation Of A Human Immunodeficiency Virus Nosode In The Treatment For Human Immunodeficiency Virus-Infected Individuals, Rajesh Shah

Indian Journal of Research in Homoeopathy

Introduction: Identifying the need for strengthening of the immune system, the investigator has developed new Human Immunodeficiency Virus (HIV) nosode and evaluated its effect on HIV positive individuals through a clinical trial. Methods: Standardized and the scientific method of HIV nosode preparation has been described and documented. Thirty-seven HIV-infected persons were registered for the trial, and ten participants were dropped out from the study, so the effect of HIV nosode 30C and 50C, was concluded on 27 participants under the trial. Results: Out of 27 participants, 7 (25.93%) showed a sustained reduction in the viral load from 12 to 24 …

Evaluation Of Homoeopathic Medicines As Add-On To Institutional Management Protocol In Acute Encephalitis Syndrome: An Exploratory Observational Comparative Study, Raj Manchanda, Praveen Oberai, Varanasi Roja, Supriya Singh, Neha Singh, Tariq Khan, Ramesh Prasad, J Singh

Indian Journal of Research in Homoeopathy

Background: Acute Encephalitis Syndrome (AES) treated according to Institutional Management Protocol (IMP) has considerable mortality and morbidity. The study was undertaken to evaluate the effect of homoeopathic treatment (H) as an add-on to IMP (IMP + H) for children affected with AES. Materials and Methods: This was an exploratory observational study carried out in the IPD setting (epidemic ward) of Baba Rhaghav Das Medical College and Nehru Hospital, Uttar Pradesh (July to November 2012) using convenience sampling. Children whose guardians gave consent were treated with IMP + H and rest remained on IMP only. Glasgow outcome scale was used at …

An Evidence-Based Case Of Acoustic/Vestibular Schwannoma, Girish Gupta, Naveen Gupta, Dileep Pandey

Indian Journal of Research in Homoeopathy

A vestibular schwannoma, often called an acoustic neuroma/schwannoma, is a benign primary intracranial tumor of the myelin-forming cells of the vestibulo-cochlear nerve (8 th cranial nerve). This tumor arises from the Schwann cells responsible for the myelin sheath that helps keep peripheral nerves insulated. [1] Approximately, 3000 cases are diagnosed each year in the United States with a prevalence of about 1 in 100,000 worldwide. It comprises 5-10% of all intracranial neoplasms in adults. Incidence peaks in the fifth and sixth decades and both sexes are affected equally. Studies in Denmark published in 2004 show the incidence of 17.4/million. Most …

Old Text Revisited: Ccrh Quarterly Bulletin, Volume 13 (1-4) 1991, Suniti Chugh

Indian Journal of Research in Homoeopathy

No abstract provided.

Changes In Speckle Tracking Echocardiography Measures Of Ventricular Function After Percutaneous Implantation Of The Edwards Sapien Transcatheter Heart Valve In The Pulmonary Position., Shahryar M. Chowdhury, Ziyad M. Hijazi, John F. Rhodes, Saibal Kar, Raj Makkar, Michael Mullen, Qi-Ling Cao, Lazar Mandinov, Jason Buckley, Nicholas P. Pietris, Girish S. Shirali

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Patients with free pulmonary regurgitation or mixed pulmonary stenosis and regurgitation and severely dilated right ventricles (RV) show little improvement in ventricular function after pulmonary valve replacement when assessed by traditional echocardiographic markers. We evaluated changes in right and left ventricular (LV) function using speckle tracking echocardiography in patients after SAPIEN transcatheter pulmonary valve (TPV) placement.

METHODS: Echocardiograms were evaluated at baseline, discharge, 1 and 6 months after TPV placement in 24 patients from 4 centers. Speckle tracking measures of function included peak longitudinal strain, strain rate, and early diastolic strain rate. RV fractional area change, tricuspid annular plane …

Assessing Usual Care In Clinical Trials, Judith A. Erlen, Lisa K. Tamres, Nancy Reynolds, Carol E. Golin, Marc I. Rosen, Robert H. Remien, Julie W. Banderas, Neil Schneiderman, Glenn Wagner, David Bangsberg, Honghu Liu

OHSU-PSU School of Public Health Faculty Publications and Presentations

Researchers designing clinical trials often specify usual care received by participants as the control condition expecting that all participants receive usual care regardless of group assignment. The assumption is that the groups in the study are affected similarly. We describe the assessment of usual care within the 16 studies in MACH 14, a multi-site collaboration on adherence to antiretroviral therapy. Only five of the studies in MACH 14 assessed usual care. Assessment protocols varied as did the timing and frequency of assessments. All usual care assessments addressed patient education focused on HIV, HIV medications, and medication adherence. Our findings support …

Sociocultural And Structural Factors Contributing To Delays In Treatment For Children With Severe Malaria: A Qualitative Study In Southwestern Uganda, Radhika Sundararajan, Juliet Mwanga-Amumpaire, Harriet Adrama, Jackline Tumuhairwe, Sheilla Mbabazi, Kenneth Mworozi, Ryan W. Carroll, David Bangsberg, Yap Boum Ii, Norma C. Ware

OHSU-PSU School of Public Health Faculty Publications and Presentations

Malaria is a leading cause of pediatric mortality, and Uganda has among the highest incidences in the world. Increased morbidity and mortality are associated with delays to care. This qualitative study sought to characterize barriers to prompt allopathic care for children hospitalized with severe malaria in the endemic region of southwestern Uganda. Minimally structured, qualitative interviews were conducted with guardians of children admitted to a regional hospital with severe malaria. Using an inductive and content analytic approach, transcripts were analyzed to identify and define categories that explain delayed care. These categories represented two broad themes: sociocultural and structural factors. Sociocultural …

Ot On College Campuses: Emerging Models Faciltitating Student Success Through Occupation, Lisa Crabtree, Carlin Daley, Jeanne Eichler, Karen Mccarthy, Victoria Schindler

Collected Faculty Scholarship

No abstract available

Vulnerable Road Users Are At Greater Risk During Ramadan -- Results From Road Traffic Surveillance Data., Amber Mehmood, Anoosh Moin, Irum Qamar Khan, Mohammad Umer Mir, Rashid Jooma

Department of Surgery Docs

Abstract

OBJECTIVE:

To assess how the frequency, nature and outcome of road traffic crashes differ during the fasting month of Ramadan.

METHODS:

The retrospective study was conducted in Karachi and comprised data from the Road Traffic Injury Surveillance Project which entailed information on all road traffic injury victims presenting to Emergency Departments in the city between September 2006 and September 2011. Data was analysed to find the frequency of road traffic crashes according to time of incident, road user group and survival. Ramadan and Non-Ramadan groups were compared with respect to time and frequency of incidents, road user group and …

Pharmacognostic Study Of Chamaecyparis Lawsoniana (Murr.) Parl.: A Drug Used In Homoeopathy, Anshu Rathi, D Baburaj, E Sundaram, Sunil Kumar, Anil Khurana, Raj Manchanda

Indian Journal of Research in Homoeopathy

The pharmacognostic profile of crude drug has a key role in standardization for quality, purity and drug identification. The present study deals with pharmacognostic evaluation of aerial part of Chamaecyparis lawsoniana (Murr.) Parl. a drug used in homoeopathic system of medicine for diverse clinical uses such as terrible pain in stomach, tumors, keloid, warts and lipoma of thigh. The study includes collection, identification, macroscopy, microscopy and organoleptic characteristics of aerial part of Chamaecyparis lawsoniana. Anatomically the leaf is distinguishable into a layer of the epidermis followed by parenchymatous mesophyll and resin duct in the parenchymatous cortex. Powder microscopy shows the …

Research Highlights: Latest Homoeopathic Research Synopsis During October - December 2014, Subhranil Saha, Munmun Koley

Indian Journal of Research in Homoeopathy

No abstract provided.

Role Of Homoeopathic Mother Tinctures In Rheumatoid Arthritis: An Experimental Study, Surender Singh, Ritu Karwasra, Prerna Kalra, Rohit Kumar, Shalu Rani, Debadatta Nayak, Y Gupta

Indian Journal of Research in Homoeopathy

Objectives: The objective of present preliminary study was to assess the anti-inflammatory, analgesic and anti-arthritic effect of some homoeopathic mother tinctures viz. Ricinus communis (RCMT), Rauwolfia serpentina (RSMT), Bellis perennis (BPMT), Curcuma longa (CLMT), Terminalia arjuna (TAMT) and Tribulus terresteris (TTMT). Materials and Methods: Paw oedema was induced by administration of 0.1ml 1% carrageenan in normal saline into right hind paw. Degree of inflammation was evaluated according to paw swelling. Arthritis was induced by Complete Freund′s Adjuvant (CFA) injection in metatarsal footpad of Wistar albino rats. Result: Curcuma longa and Tribulus terresteris mother tinctures reduced hind paw swelling decreased the …

Reliance On Auditory Feedback In Children With Childhood Apraxia Of Speech, Jenya Iuzzini-Seigel, Tiffany P. Hogan, Anthony J. Guarino, Jordan R. Green

Speech Pathology and Audiology Faculty Research and Publications

Children with childhood apraxia of speech (CAS) have been hypothesized to continuously monitor their speech through auditory feedback to minimize speech errors. We used an auditory masking paradigm to determine the effect of attenuating auditory feedback on speech in 30 children: 9 with CAS, 10 with speech delay, and 11 with typical development. The masking only affected the speech of children with CAS as measured by voice onset time and vowel space area. These findings provide preliminary support for greater reliance on auditory feedback among children with CAS.

Learning outcomes: Readers of this article should be able to (i) …

Environmental Microbes And Uveitis: Is Microbial Exposure Always Bad?, Chandirasegaran Massilamany, A. Gangaplara, J. Reddy

School of Veterinary and Biomedical Sciences: Faculty Publications

The eye generally is considered to be an immune-privileged organ, but this notion is being increasingly challenged as ocular antigens can be expressed in the generative lymphoid organs, resulting in attainment of self-tolerance. What triggers a break in this tolerant state is a fundamental question in autoimmunity research. The general belief is that exposure to environmental microbes can break self-tolerance in genetically susceptible individuals, leading to the induction of autoimmune responses. The molecular mimicry hypothesis has been proposed as one major mechanistic, pathway through which microbes, by generating crossreactive immune responses, can induce ocular damage of the kind that might …