Medicine and Health Sciences Commons^™

Tatalaksana Terkini Perlemakan Hati Non Alkoholik, Randy Adiwinata, Andi Kristanto, Finna Christianty, Timoteus Richard, Daniel Edbert

Jurnal Penyakit Dalam Indonesia

Perlemakan Hati Non Alkoholik (Non Alcoholic Fatty Liver Disease/NAFLD) merupakan salah satu penyebab utama dari penyakit hati kronis di negara berkembang. NAFLD dapat berkembang menjadi menjadi penyakit hati yang lebih berat seperti Non Alcoholic Steatohepatis (NASH), sirosis hepatis, dan karsinoma hati. Tatalaksana NAFLD terus berkembang, dan saat ini klinisi dihadapkan dengan berbagai pilihan alternatif baik dari segi nonfarmakoterapi maupun farmakoterapi. Tulisan ini akan membahas berbagai pilihan terapi NAFLD terkini tersebut berdasarkan bukti terbaru.

Shining The Spotlight On Diabetes, Rodney Richmond

Faculty Research ​and Publications

No abstract provided.

The Effect Of Quality Of Life And Health Behaviors In Schizotypy, Victoria Giordano

Theses and Dissertations

Individuals diagnosed with schizophrenia are typically found to engage in higher rates of poorer health behaviors, such as higher rates of smoking and poorer nutrition. Along with poorer health behaviors, individuals with schizophrenia tend to report a lower quality of life than an individual without a schizophrenia diagnosis. Our study chose to look at schizotypy, or sub-clinical schizophrenia, and its relation to quality of life and health behaviors. We found that individuals that measure high on the subclinical schizotypy scale tend to mirror the health and quality of life ratings of an individual diagnosed with schizophrenia - they are more …

The Impact Of The Veterans Health Administration's Home Based Primary Care On Health Services Use, Expenditures, And Mortality, Melissa Castora-Binkley

USF Tampa Graduate Theses and Dissertations

Background: Among patients with multiple chronic conditions, care coordination and integration remains one of the major challenges facing the U.S. health care system. A home-based, patient-centered primary care program has been offered through the Veterans Health Administration (VHA) since the 1970s for frail veterans who have difficulty accessing VHA clinics. The VHA Home Based Primary Care (VHA HBPC) aims to integrate primary care, rehabilitation, disease management, palliative care, and coordination of care for frail individuals with complex, chronic diseases within their homes. Early research suggested that VHA HBPC was associated with positive outcomes (e.g., reduced resource use and patient satisfaction). …

Good Fences Make For Good Neighbors But Bad Science: A Review Of What Improves Bayesian Reasoning And Why, W. Trey Hill

Psychology Faculty Publications

Bayesian reasoning, defined here as the updating of a posterior probability following new information, has historically been problematic for humans. Classic psychology experiments have tested human Bayesian reasoning through the use of word problems and have evaluated each participant’s performance against the normatively correct answer provided by Bayes’ theorem. The standard finding is of generally poor performance. Over the past two decades, though, progress has been made on how to improve Bayesian reasoning. Most notably, research has demonstrated that the use of frequencies in a natural sampling framework—as opposed to single-event probabilities—can improve participants’ Bayesian estimates. Furthermore, pictorial aids and …

A Study Examining Practice Style Traits Of Physical Therapists: Do They Explain Practice Behaviors And Knowledge Translation?, Kristen M. Johnson

Student Dissertations

Background: The advancement of evidence-based practice (EBP) has generated a flurry of outcome measures (OMs) and continuing education courses to assist in the creation and tailoring of this knowledge to the clinical environment. Despite the development of these resources, little is known about the attributes and behaviors of the physical therapist for knowledge translation (KT) into clinical practice.

Purpose: To determine the practice style traits of physical therapists who attended an evidence-based continuing education course on Oms and to determine their perceived barriers, facilitators, attitudes, knowledge, behaviors, and prerequisites for KT.

Methods: Seventy-nine physical therapists completed two standardized, validated surveys …

Estimation Du Chargement Lombaire Au Moyen De Modèles Biomécaniques Articulaires : Évaluation Et Application, André Plamondon, Christian Larivière, Navid Arjmand, Denis Gagnon, Zakaria El Ouaaid, Ali Shahvarpour, Aboulfazl Shirazi-Adl

Rapports de recherche scientifique

Les troubles musculosquelettiques (TMS) et tout particulièrement les affections vertébrales constituent un fardeau autant pour la société que pour les personnes qui en sont affectées. Au Québec, le nombre d’affections vertébrales s’établissait en 2011 à 21 228 et elles représentaient près de 30 % de l’ensemble des lésions professionnelles indemnisées. C’est la région lombaire de la colonne vertébrale qui est la zone la plus touchée (60 % des cas d’affections) et l’effort excessif est l’agent causal le plus souvent rapporté (40 %). Selon le National Research Council (2001), il existe une relation claire entre les lésions au dos et la …

Epidemiology News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• Acceptability and Feasibility of Physical Activity Assessment Methods

The Benefits Of Breastfeeding, Helen L. Byers

Senior Honors Theses

It is important to educate women of childbearing age, their families, and society of the benefits that breastfeeding has over bottle-feeding and formula-feeding. The benefits of breastfeeding are in three main categories. First, the developmental, physical, emotional, and spiritual benefits of the baby will be discussed. Then the physical, emotional, and spiritual benefits for the mother will be talked about along with possible contraindications or difficulties. Finally, the financial benefits of breastfeeding over feeding an infant from the bottle will be discussed as it relates to the family and government. The goal is to persuade that breastfeeding is a superior …

Formative Research On An Instructional Design Theory For Virtual Patients In Clinical Education: A Pressure Ulcer Prevention Clinical Reasoning Case, Manon Maitland Schladen

CCAC Theses and Dissertations

Despite advances in health care over the past decades, medical errors and omissions remain significant threats to patient safety and health. A large number of these mistakes are made by trainees, persons who are just beginning to build the case-based experiences that will transform them from novices to expert practitioners. Clinicians use both intuitive and deductive problem-solving skills in caring for patients and they acquire expertise in applying these skills through interaction with many and varied cases.

The contemporary heath care environment, with decreased lengths of stay for patients and reduced duty hours for trainees, makes getting optimal patient exposure …

Focused Ultrasound For Treatment Of Bone Tumours., Dario B. Rodrigues, Paul R. Stauffer, David Vrba, Mark Hurwitz, Md

Department of Radiation Oncology Faculty Papers

PURPOSE: Focused ultrasound (FUS) is a modality with rapidly expanding applications across the field of medicine. Treatment of bone lesions with FUS including both benign and malignant tumours has been an active area of investigation. Recently, as a result of a successful phase III trial, magnetic resonance-guided FUS is now a standardised option for treatment of painful bone metastases. This report reviews the clinical applications amenable to treatment with FUS and provides background on FUS and image guidance techniques, results of clinical studies, and future directions.

METHODS: A comprehensive literature search and review of abstracts presented at the recently completed …

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Acceptability and Feasibility of Physical Activity Assessment Methods

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Acceptability and Feasibility of Physical Activity Assessment Methods

Interaction Pattern For The Complex Of B-Dnafullerene Compounds With A Set Of Known Replication Proteins Using Docking Study, Sumbul Firdaus, Anupam Dhasmana, Vandana Srivastava, Tasneem Bano, Afreen Fatima, Qazi Mohammad Sajid Jamal, Roshan Jahan, Gulshan Wadhwad, Mohtashim Lohani

School of Medicine Publications

Fullerenes have attracted considerable attention due to their unique chemical structure and potential applications which has opened wide venues for possible human exposure to various fullerene types. Therefore, in depth knowledge of how fullerene may interfere with various cellular processes becomes quite imperative. The present study was designed to investigate how the presence of fullerene affect the binding of DNA with different enzymes involved in replication process. Different fullerenes were first docked with DNA and then binding scores of different enzymes was analyzed with fullerene docked DNA. C30, C40 & C50 once docked with DNA, reduced the binding score of …

Direct Current Stimulation To Increase Cerebrovascular Function, V. M. Pulgar

Pharmaceutical Sciences

No abstract provided.

Direct Current Stimulation To Increase Cerebrovascular Function, V. M. Pulgar

Pharmaceutical Sciences

No abstract provided.

What's Happening: March 30, 2015, Maine Medical Center

What's Happening

No abstract provided.

The Emerging Role Of Ng2 In Pediatric Diffuse Intrinsic Pontine Glioma., Sridevi Yadavilli, Joseph Scafidi, Oren J. Becher, Amanda M. Saratsis, Rebecca L. Hiner, Madhuri Kambhampati, Santi Mariarita, Tobey J. Macdonald, Kari-Elise Codispoti, Suresh N. Magge, Jyoti K. Jaiswal, Roger J. Packer, Javad Nazarian

Neurology Faculty Publications

Diffuse intrinsic pontine gliomas (DIPGs) have a dismal prognosis and are poorly understood brain cancers. Receptor tyrosine kinases stabilized by neuron-glial antigen 2 (NG2) protein are known to induce gliomagenesis. Here, we investigated NG2 expression in a cohort of DIPG specimens (n= 50). We demonstrate NG2 expression in the majority of DIPG specimens tested and determine that tumors harboring histone 3.3 mutation express the highest NG2 levels. We further demonstrate that microRNA 129-2 (miR129-2) is downregulated and hypermethylated in human DIPGs, resulting in the increased expression of NG2. Treatment with 5-Azacytidine, a methyltransferase inhibitor, results in NG2 downregulation in DIPG …

The Role Of Zinc And Iron-Folic Acid Supplementation On Early Child Temperament And Eating Behaviors In Rural Nepal: A Randomized Controlled Trial, Pamela J. Surkan, Mary Katherine Charles, Joanne Katz, Emily H. Siegel, Subarna K. Khatry, Steven C. Leclerq, Rebecca J. Stoltzfus, James M. Tielsch

Global Health Faculty Publications

Child eating behaviors play an important role in nutrient intake, ultimately affecting child growth and later outcomes in adulthood. The study assessed the effects of iron-folic acid and zinc supplementation on child temperament and child eating behaviors in rural Nepal. Children (N = 569) aged 4–17 months in Sarlahi district, southern Nepal were randomized to receive daily supplements of placebo, iron-folic acid, zinc, or zinc plus iron-folic acid and followed for approximately 1 year. At baseline and four follow-up visits mothers completed questionnaires including information on demographic characteristics and child temperament and eating behaviors. The main effects of zinc and …

Preliminary Analysis Of In Utero Low-Level Arsenic Exposure And Fetal Growth Using Biometric Measurements Extracted From Fetal Ultrasound Reports, Matthew A. Davis, John Higgins, Zhigang Li, Diane Gilbert-Diamond, Emily R. Baker, Amar Das, Margaret R. Karagas

Dartmouth Scholarship

Background: Early life exposure to arsenic is associated with decreased birth weight in highly exposed populations but little is known about effects of low-level arsenic exposure on growth in utero.

Methods: Using a sample of 272 pregnancies from New Hampshire we obtained biometric measurements directly from fetal ultrasound reports commonly found in electronic medical records. We used information extraction methods to develop and validate an automated approach for mining biometric measurements from the text of clinical reports. As a preliminary analysis, we examined associations between in utero low-level arsenic exposure (as measured by maternal urinary arsenic concentration) and fetal growth …

G9a Is Essential For Emt-Mediated Metastasis And Maintenance Of Cancer Stem Cell-Like Characters In Head And Neck Squamous Cell Carcinoma, Shuli Liu, Dongxia Ye, Wenzheng Guo, Wenwen Yu, Yue He, Jingzhou Hu, Yanan Wang, Ling Zhang, Yueling Liao, Hongyong Song, Shuangshuang Zhong, Dongliang Xu, Huijing Yin, Beibei Sun, Xiaofei Wang, Jingyi Liu, Yadi Wu, Binhua P. Zhou, Zhiyuan Zhang, Jiong Deng

Markey Cancer Center Faculty Publications

Head and neck squamous cell carcinoma (HNSCC) is a particularly aggressive cancer with poor prognosis, largely due to lymph node metastasis and local recurrence. Emerging evidence suggests that epithelial-to-mesenchymal transition (EMT) is important for cancer metastasis, and correlated with increased cancer stem cells (CSCs) characteristics. However, the mechanisms underlying metastasis to lymph nodes in HNSCC is poorly defined. In this study, we show that E-cadherin repression correlates with cancer metastasis and poor prognosis in HNSCC. We found that G9a, a histone methyltransferase, interacts with Snail and mediates Snail-induced transcriptional repression of E-cadherin and EMT, through methylation of histone H3 lysine-9 …

A Study Of Low Weight Bearing Exercise And Its Effect On Bone Density, Elizabeth Markle

Undergraduate Honors Thesis Projects

Exercise has been a proven key to maintaining overall good health. There are many benefits of exercise: improved blood flood and overall heart strength, stronger muscles, improved cardiovascular system and it actively works to prevent superfluous fat storage on the body (Bassuk, 2013). Among these benefits is also the improvement and strengthening of bones (Bassuk, 2013). Bone strength can also be referred to as bone density and is very important to a person’s overall health because it relates directly to skeletal strength, posture, factors that affect falling and consequentially the fracturing of bones (Mayo Clinic Health Letter, 2011). A higher …

Medical School Watercooler Newsletter - March 29, 2015, Lindsey Lyle

Watercooler Newsletter

This is the March 29, 2015 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

Mark Your Calendar: Sickle Cell Regional Conference

USA Obstetrics and Gynecology Employees Recognized for Customer Service

USA Welcomes Certified Nurse Midwife

April Med School Café - 'Choose Healthy'

Medical Students In Microscopic Anatomy And Pathology Laboratories: Design Of An E-Learning Histology And Histopathology Atlas As An Evolving Response To Interdisciplinary Pre-Clinical Curricular Needs, Michelle S. Davis, Alexandra Mills, Gisela Butera, Donald S. Karcher, Patricia S. Latham, Janette Krum, Rosalyn A. Jurjus

Anatomy and Regenerative Biology Faculty Publications

E-learning, also known as computer-assisted learning, successfully bridges anatomical knowledge and transferrable skills, such as critical analysis, teamwork, leadership and communication. Several institutions have already integrated histology and physiology in team based laboratory approaches, but integration of histology and pathology instruction has been done to a lesser extent. Our aim was to develop an e-learning atlas that integrates microanatomy and pathology laboratory for an interdisciplinary pre-clinical medical curriculum.

A multidisciplinary team of teaching faculty and students developed an online atlas (microanatomyatlas.com) that includes a library of histology and histopathology images. Traditional laboratory manual instructions and study objectives were added onto …

Finding A Foal Amongst The Zebras: An Uncommon Presentation Of Lemierre’S Syndrome, Saisho Mangla Do, Claudia F. Busse Md, Liborio Larussa Md

Department of Pediatrics

No abstract provided.

45rd Annual Wku Student Research Conference, Student Research Council

Student Research Conference Select Presentations

See document below for project abstracts

Impact Of Incremental Perfusion Loss On Oxygen Transport In A Capillary Network Mathematical Model., Graham M Fraser, Michael D Sharpe, Daniel Goldman, Christopher G Ellis

Medical Biophysics Publications

OBJECTIVES: To quantify how incremental capillary perfusion loss, such as that seen in experimental models of sepsis, affects tissue oxygenation using a computation model of oxygen transport.

METHODS: A computational model was applied to capillary networks with dimensions 84x168x342 (NI) and 70x157x268 (NII) μm, reconstructed in vivo from rat skeletal muscle. Functional capillary density (FCD) loss was applied incrementally up to ~40% and combined with high tissue oxygen consumption to simulate severe sepsis.

RESULTS: A loss of ~40% FCD loss decreased median tissue PO2 to 22.9 and 20.1 mmHg in NI and NII compared to 28.1 and 27.5 mmHg under …

Effects Of Periodontal Therapy On White Blood Cell Count And Levels Of Transforming Growth Factor Beta In Serum Of Subjects With Severe Periodontitis, A. C. E. Leite, V. M. A. Carneiro, Ana Carolina Morandini, Erivan Schnaider Ramos-Junior, M. C. M. Guimarães

All Dugoni School of Dentistry Faculty Articles

This study aimed to investigate the effects of nonsurgical periodontal therapy on white blood cell (WBC) count and levels of transforming growth factor beta (TGF—β) in serum from subjects with severe periodontitis. Serum from 28 subjects with periodontitis (mean age: 34.36±6.24; 32% men) and 27 healthy controls (mean age: 33.18±6.42; 33% men) were collected prior to therapy. Blood samples were obtained from 23 subjects who completed therapy (9—12 months). A well—controlled periodontal treatment protocol was established in three stages: mechanical periodontal therapy (scaling and root planning), reinstrumentation of dental sites, and supportive periodontal therapy. Periodontal and systemic parameters such as …

Burden Of Periprosthetic Joint Infection And Its Treatment On Kidney Function

Rothman Institute Conference Posters

Introduction:

Patients with periprosthetic joint infection (PJI) are subjected to several potentially nephrotoxic conditions such as acute and chronic systemic inflammatory reactions, multiple surgical procedures and noxious antibiotics. This study aims to investigate 1) the incidence and severity of kidney injury in patients undergoing surgical treatment for PJI, 2) whether the number of surgeries affects renal function in PJI patients and 3) the potential risk factors for kidney injury.

Fearless Friday: Sarah Van De Weert, Christina L. Bassler

SURGE

Sarah Van De Weert ’16 has been fearlessly striving to eliminate the stigma surrounding mental health disorders. As the current president of Active Minds, Secretary of APO, and a member of the Honor Commission Sarah works toward a more inclusive campus community, especially for those suffering from mental illnesses. Sarah also conducts research for Dr. Berenson and works for a non-profit called Libero Network. Sarah’s participation in Active Minds on campus focuses on spreading awareness of mental illnesses and reducing the stigmas surrounding them, along with advocating for Gettysburg College to be a safe and open environment for discussions about …