Medicine and Health Sciences Commons^™

Pubh 9130 - Professional Seminar In Biostatistics, Robert Vogel

College of Public Health: Faculty Syllabi (2014-2021)

This course focuses on study design and sampling methods as well as data analysis of small and large, national and local health surveys and vital statistics in order to gain experience describing data using effective graphical and numerical methods. Students will use statistical software (SAS) to analyze data originating from various survey designs, including data from experimental designs such as parallel, longitudinal studies that involve several treatment or intervention groups. Students will work in groups on data analysis projects and case studies in order to be exposed to others' expertise in different areas of public health and to learn effective …

Pubh 9630 - Public Health Doctoral Seminar, Joseph Telfair

College of Public Health: Faculty Syllabi (2014-2021)

This course is designed to provide doctoral candidates with instruction and practice allowing for the enhancement of knowledge and skills in the areas of critical thinking, information analyses and synthesis, and scientific writing. Give doctoral candidates the opportunity to determine, refine and comprehensively (written, oral) describe their dissertation research topic. Work with doctoral candidates to thoroughly identify, research, screen, then secure commitment from potential dissertation committee members, particularly the chair.

Clinical Profiles And Outcomes Of Children Admitted To The Pediatric Intensive Care Unit From The Emergency Department, Anwarul Haque, Naveed Ur Rehman Siddiqui, Sidra Kaleem Jafri, Mehar Hoda, Surraiya Bano, Asad Mian

Department of Paediatrics and Child Health

The aim of this study was to describe clinical profiles and outcomes of children admitted directly from the Emergency Room (ER) to the Pediatric Intensive Care Unit (PICU) of academic hospital. The medical records of all children (1 month to 16 years) admitted in PICU from ER, from January 2011 to December 2012 were reviewed. Of the 26,774 patients seen in the ER during the study period, 468 (1.7%) were admitted to the PICU which constituted about 41.5% (468/1127) of all the total PICU admissions. Sixty three percent (n=294) were under-five; males were 60.9% (285), 82.3% (385) were in medical …

Isoniazid Induced Acute Pancreatitis In A Young Girl, Ali Faisal Saleem Dr, Saba Arbab, Farah Qamar Naz

Department of Paediatrics and Child Health

Isoniazid (INH) is the mainstay of management against Mycobacterium tuberculosis. INH-induced acute pancreatitis is an uncommon association and with dearth of literature on it. We are reporting a case of an 11 years old girl who developed acute pancreatitis after 2 weeks of antituberculous therapy. An INH free regimen was started. She was discharged and followed without complications.

Introduction To Aims Special Issue “Obesity And Food Intake In Vulnerable Populations”, Junfeng Jiao

Research Collection College of Integrative Studies

With global obesity on the rise, the need for research concerning the complexity of risk factors is more important than ever. While the increase of the high-calorie, low-nutrient food supply correlates with rising weights, new studies across disciplines reveal the intricacy of the environmental and circumstantial phenomena that influence obesity rates and behaviors for at-risk individuals. AIMS Public Health is pleased to present this special issue entitled “Obesity and Food Intake in Vulnerable Populations” in support of this research. This edition contains two research reviews, a research study, and a brief report related to obesity and human behavior.

Pathways Involved In Interleukin-1Β-Mediated Murine Cardiomyocyte Apoptosis, Yi Shen, Jie Qin, Peili Bu

The Texas Heart Institute Journal

Accumulating evidence suggests that interleukin-1 (IL-1) signaling plays an essential role in the pathogenesis of heart failure by inducing cardiomyocyte apoptosis, but the mechanisms of this process are poorly defined. We further explored these molecular pathways.

We isolated cardiomyocytes from neonatal mice and then cultured and stimulated them with murine IL-1β in vitro. Cell apoptotic ratios were measured by means of flow cytometry. Expression of effector molecules was analyzed by means of enzyme-linked immunosorbent assay, Western blotting, and real-time quantitative polymerase chain reaction. The results showed that IL-1β induced murine cardiomyocyte apoptosis through a release of cytochrome c into cytoplasm …

When The Chief Complaint Tells It All, Herbert L Fred

The Texas Heart Institute Journal

No abstract provided.

Prenatal Diagnosis Of Left Pulmonary Artery-To-Pulmonary Vein Fistula And Its Successful Surgical Repair In A Neonate, Oleksii Ostras, Andrii Kurkevych, Lyubomyr Bohuta, Tetyana Yalynska, Tammo Raad, Mark Lewin, Illya Yemets

The Texas Heart Institute Journal

Pulmonary arteriovenous fistula is a rare disease. To the best of our knowledge, prenatal diagnosis of a fistula between the left pulmonary artery and the left pulmonary vein has not been described in the medical literature. We report a case of the prenatal diagnosis of a left pulmonary artery-to-pulmonary vein fistula, followed by successful neonatal surgical repair.

Transcatheter Aortic Valve Implantation Despite Challenging Vascular Access, Angelo Nascimbene, Federico Azpurua, James J Livesay, R David Fish, Zvonimir Krajcer

The Texas Heart Institute Journal

We describe transcatheter aortic valve implantation in a patient who had severe peripheral artery disease. The patient's vascular condition required additional preliminary peripheral intervention to enable adequate vascular access.

A 78-year-old man with severe aortic stenosis, substantial comorbidities, and severe heart failure symptoms was referred for aortic valve replacement. The patient's 20-mm aortic annulus necessitated the use of a 23-mm Edwards Sapien valve inserted through a 22F sheath, which itself needed a vessel diameter of at least 7 mm for percutaneous delivery. The left common femoral artery was selected for valve delivery. The left iliac artery and infrarenal aorta underwent …

Regression Of Left Ventricular Mass After Implantation Of The Sutureless 3f Enable Aortic Bioprosthesis, Giovanni Concistrè, Antonio Miceli, Federica Marchi, Francesca Chiaramonti, Mattia Glauber, Marco Solinas

The Texas Heart Institute Journal

Left ventricular hypertrophy in aortic stenosis is considered a compensatory response for the maintenance of systolic function but a risk factor for cardiac morbidity and death. We investigated the degree of left ventricular mass regression after implantation of the sutureless Medtronic 3f Enable® Aortic Bioprosthesis.

We studied 19 patients who, from May 2010 through July 2011, underwent isolated aortic valve replacement with the 3f Enable bioprosthetic valve, with clinical and echocardiographic follow-up at 6 months. The mean age was 77.1 ± 5.1 years (range, 68–86 yr); 14 patients were women (73.7%); and the mean logistic EuroSCORE was 15.4% ± 11.8%. …

Growing South Dakota (Spring 2015), College Of Agriculture &. Biological Sciences

Growing South Dakota (Publication of the College of Agriculture, Food and Environmental Sciences)

This issue includes the 2014 SDSU Extension Annual Report.

[Page] 2 Committed To South Dakotans: Programs Focus On “Healthy Food, Healthy Families, Healthy Communities”
[Page] 4 Serving South Dakota’s Multi-Cultural Communities: Programs Take Root In Sioux Falls And On Standing Rock Indian Reservation
[Page] 4 Relevant Resource: New Manual Provides Guidance For Farmers Markets
[Page] 6 Food Growers Unite: Formation Of “Food Hub” Being Explored
[Page] 8 Envisioning The Future: Extension Assists Community Leaders With Forward Thinking
[Page] 10 Innovative New Tools: Online Resources Provide Useful Climate Data, Drainage Calculators
[Page] 12 Meeting Producer Needs: Production Knowledge Enhanced With Extension …

Glutalytic Clinical Trial For Normal Consumptionof Gluten Containing Foods, Martin Hudson, Colin King

Faculty Articles

Background
Gluten sensitivity and the incidence of Celiac disease are ever increasing. The aim was to measure the effectiveness of an enzyme based dietary supplement on the reduction of symptoms encountered upon the consumption of gluten.

Results
The data showed a statistically significant improvement when compared to the placebo group in the following categories: pain, bloating, emptying of bowels, hunger pains, rumbling of stomach, lower energy levels, headaches, and food cravings. There was no statistically signficant improvement in the following symptoms: comfort, nausea, and loss of appetite.

Conclusion
Overall, the dietary supplement, Glutalytic, reduced many of the symptoms that are …

Masking Tuberculosis Patients, James Bowen, Austin Greenwood

Graduate Research Projects

Authors proposed a study to determine what effect a non-fit-tested patient-worn surgical mask has on inpatient tuberculosis transmission rates as compared to no mask usage.

Effectiveness Of Two Various Types Of School-Based Instruction Methods In Relation To Bmi, Physical Activity, And Nutrition Outcomes, Sherri Bakland, Elizabeth Moore-Jones

Graduate Research Projects

No abstract provided.

Transcriptomic Identification Of Adh1b As A Novel Candidate Gene For Obesity And Insulin Resistance In Human Adipose Tissue In Mexican Americans From The Veterans Administration Genetic Epidemiology Study (Vages), Deidre A. Winnier, Marcel Fourcaudot, Luke Norton, Muhammad A. Abdul-Ghani, Shirley L. Hu, Thomas D. Dyer, Joanne E. Curran, John Blangero, Ravi Duggirala, Harald H. H. Goring

School of Medicine Publications

Type 2 diabetes (T2D) is a complex metabolic disease that is more prevalent in ethnic groups such as Mexican Americans, and is strongly associated with the risk factors obesity and insulin resistance. The goal of this study was to perform whole genome gene expression profiling in adipose tissue to detect common patterns of gene regulation associated with obesity and insulin resistance. We used phenotypic and genotypic data from 308 Mexican American participants from the Veterans Administration Genetic Epidemiology Study (VAGES). Basal fasting RNA was extracted from adipose tissue biopsies from a subset of 75 unrelated individuals, and gene expression data …

Influence Of Depression, Anxiety And Stress On Cognitive Performance In Community-Dwelling Older Adults Living In Rural Ecuador: Results Of The Atahualpa Project, Oscar H. Del Brutto, Robertino M. Mera, Victor J. Del Brutto, Gladys Maestre, Hannah Gardener, Mauricio Zambrano, Clinton B. Wright

School of Medicine Publications

Aim:

To assess the relationship between cognitive status and self-reported symptoms of depression, anxiety and stress of older adults living in an underserved rural South American population.

Methods:

Community-dwelling Atahualpa residents aged ≥60 years were identified during a door-to-door census, and evaluated with the Depression Anxiety Stress Scale-21 (DASS-21) and the Montreal Cognitive Assessment (MoCA). We explored whether positivity in each of the DASS-21 axes was related to total and domain-specific MoCA performance after adjustment for age, sex and education.

Results:

A total of 280 persons (59% women; mean age, mean age 70 ± 8 years) were included. Based on …

Diffusion Of Inclusion: Measuring Willingness, Janet A. Levey

Dissertations (1934 -)

The purpose of the study was to: (1) examine psychometric properties of the Willingness to Adopt Inclusive Teaching Strategies (ITSinNE) instrument and (2) measure factors influencing a nurse educator's willingness to adopt inclusive teaching strategies based in universal design for instruction (UDI). Universal design for instruction (UDI) is one approach to facilitate multiple ways of learning and evaluation in various learning environments for all learners; however, it is not well known or researched in nursing education. Diffusion of innovation theory (Rogers, 2003) and universal design for instruction (McGuire & Scott, 2006) provided the theoretical framework for the study. A cross-sectional …

Effect Of Perceived Stress On Cytokine Production In Healthy College Students, Vorachai Sribanditmongkol, Jeremy L. Neal, Laura A. Szalacha, Donna O. Mccarthy

College of Nursing Faculty Research and Publications

Chronic psychological stress impairs antibody synthesis following influenza vaccination. Chronic stress also increases circulating levels of proinflammatory cytokines and glucocorticoids in elders and caregivers, which can impair antibody synthesis. The purpose of this study was to determine whether psychological stress increases ex vivo cytokine production or decreases glucocorticoid sensitivity (GCS) of peripheral blood leukocytes from healthy college students. A convenience sample of Reserve Officer Training Corps (ROTC) students completed the Perceived Stress Scale (PSS). Whole blood was incubated in the presence of influenza vaccine and dexamethasone to evaluate production of interleukin-6 (IL-6), interleukin-1-beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and interferon-gamma …

Comparison Of Nurse Staffing Based On Changes In Unit-Level Workload Associated With Patient Churn, Ronda G. Hughes, Kathleen Bobay, Nicholas A. Jolly, Chrysmarie Suby

College of Nursing Faculty Research and Publications

Aim

This analysis compares the staffing implications of three measures of nurse staffing requirements: midnight census, turnover adjustment based on length of stay, and volume of admissions, discharges and transfers.

Background

Midnight census is commonly used to determine registered nurse staffing. Unit-level workload increases with patient churn, the movement of patients in and out of the nursing unit. Failure to account for patient churn in staffing allocation impacts nurse workload and may result in adverse patient outcomes.

Method(s)

Secondary data analysis of unit-level data from 32 hospitals, where nursing units are grouped into three unit-type categories: intensive care, intermediate care, …

Spectropathology For The Next Generation: Quo Vadis?, Hugh Byrne, Malgorzata Baranska, Gerwin J. Pupples, Nick Stone, Bayden Wood, Kathleen M. Gough, Peter Lasch, Phil Heraud, Josep Sulé-Suso, Ganesh Sockalingum

Articles

Although the potential of vibrational spectroscopy for biomedical applications has been well demonstrated, translation into clinical practice has been relatively slow. This Editorial assesses the challenges facing the field and the potential way forward. While many technological challenges have been addressed to date, considerable effort is still required to gain acceptance of the techniques among the medical community, standardise protocols, extend to a clinically relevant scale, and ultimately assess the health economics underlying clinical deployment. National and international research networks can contribute much to technology development and standardisation. Ultimately, large-scale funding is required to engage in clinical trials and instrument …

Multicountry Prospective Clinical Evaluation Of Two Enzyme-Linked Immunosorbent Assays And Two Rapid Diagnostic Tests For Diagnosing Dengue Fever, Subhamoy Pal, Allison Dauner, Andrea Valks, Brett M. Forshey, Kanya C. Long, Butsaya Thaisomboonsuk, Gloria Sierra, Victor Picos, Sara Talmage, Amy C. Morrison, Eric S. Halsey, Guillermo Comach, Chadwick Yasuda, Michael Loeffelholz, Richard G. Jarman, Stefan Fernandez, Ung Sam An, Tadeusz J. Kochel, Louis E. Jasper, Shuenn-Jue L. Wu

Faculty Publications

We evaluated four dengue diagnostic devices from Alere, including the SD Bioline Dengue Duo (nonstructural [NS] 1 Ag and IgG/IgM), the Panbio Dengue Duo Cassette (IgM/IgG) rapid diagnostic tests (RDTs), and the Panbio dengue IgM and IgG capture enzyme-linked immunosorbent assays (ELISAs) in a prospective, controlled, multicenter study in Peru, Venezuela, Cambodia, and the United States, using samples from 1,021 febrile individuals. Archived, well-characterized samples from an additional 135 febrile individuals from Thailand were also used. Reference testing was performed on all samples using an algorithm involving virus isolation, in-house IgM and IgG capture ELISAs, and plaque reduction neutralization tests …

Medical Students In Microscopic Anatomy And Pathology Laboratories: Design Of An E-Learning Histology And Histopathology Atlas, Alexandra Mills, Michelle Davis, Donald Karcher, Patricia S. Latham, Janet Krum, Gisela Butera, Rosalyn A. Jurjus

GW Research Days 2015

Computer-assisted learning, also known as e-learning, has been successfully implemented to educate students in anatomical knowledge as well as transferable skills, such as critical analysis, teamwork, leadership and communication. E-learning allows students to self-teach material at their own paces and provides a platform for team-based laboratory approaches.

Several institutions have already integrated histology and physiology in team based laboratory approaches, but integration of histology and pathology instruction has been done to a lesser extent. Our aim was to develop an e-learning atlas that integrates microanatomy and pathology laboratory for an interdisciplinary pre-clinical medical curriculum.

A multidisciplinary team of teaching faculty …

Kolaborasi Tata Laksana Dan Pengendalian Tuberkulosis Dan Diabetes Melitus, Anna Ujainah

Jurnal Penyakit Dalam Indonesia

Pada akhir tahun 2014, diabetes mellitus (DM) diperkirakan menjadi kontributor 15% kasus tuberkulosis (TB) di dunia. Ancaman kesehatan akibat TB potensial meningkat seiring dengan peningkatan angka penyandang DM.

Faktor-Faktor Yang Berkorelasi Dengan Status Nutrisi Pada Pasien Continuous Ambulatory Peritoneal Dialysis (Capd), Mira Yulianti, Suhardjono Suhardjono, Triyani Kresnawan, Kuntjoro Harimurti

Jurnal Penyakit Dalam Indonesia

Pendahuluan: Perubahan status nutrisi dikaitkan dengan tingginya mortalitas pada kelompok pasien penyakit ginjal tahap akhir (PGTA). Berbagai penelitian menunjukkan tingginya prevalensi malnutrisi pada pasien dialisis kronik, namun hingga saat ini, penelitian lebih banyak dilakukan pada pasien yang menjalani hemodialisis. Dengan latar belakang berkembangnya CAPD di Indonesia, perlu diteliti faktor-faktor yang berkaitan dengan kesintasan pasien CAPD untuk menekan tingginya morbiditas dan mortalitas pada kelompok pasien tersebut, salah satunya adalah faktor nutrisi.

Metode: Penelitian ini merupakan studi potong lintang pada kelompok pasien PGTA yang menjalani CAPD yang kontrol ke RSCM dan RS Satelit. Dilakukan pengumpulan data denga wawancara, pemeriksaan fisik, …

Profil Pasien Kaki Diabetes Yang Menjalani Reamputasi Di Rumah Sakit Cipto Mangunkusumo Tahun 2008 -2012, Yohana Sitompul, Budiman Budiman, Suharko Soebardi, Murdani Abdullah

Jurnal Penyakit Dalam Indonesia

Pendahuluan. Prevalensi diabetes global diprediksi akan meningkat sebesar dua kali lipat pada tahun 2030 dari 2,8% menjadi 4,4% (berkisar 366 juta) dengan angka komplikasi kaki diabetes berkisar 10%. Ulkus diabetes dan amputasi ekstremitas bawah merupakan komplikasi diabetes yang akan meningkatkan mortalitas dan morbiditas Setelah lima tahun amputasi pertama, 28-51% pasien akan menjalani amputasi kedua. Penelitian ini dilakukan untuk mengetahui proporsi dan profil pasien yang mengalami reamputasi di Rumah Sakit Cipto Mangunkusumo tahun 2008-2012.

Metode. Disain studi ini adalah potong lintang dengan 80 subjek pasien kaki diabetes yang dirawat di RSCM tahun 2008 sampai 2012. Dilakukan pencatatan data yang …

Serokonversi Hepatitis C Pada Pasien Hemodialisis Di Rumah Sakit Cipto Mangunkusumo, Alvina Widhani, Aida Lydia, Rino A. Gani, Siti Setiati

Jurnal Penyakit Dalam Indonesia

Pendahuluan. Pasien hemodialisis (HD) tergolong kelompok risiko tinggi terinfeksi virus hepatitis C. Penelitian mengenai serokonversi hepatitis C di RS Cipto Mangunkusumo belum pernah dilakukan. Agar transmisi hepatitis C dapat diturunkan, faktor risiko serokonversi hepatitis C penting diketahui. Penelitian ini bertujuan mengetahui proporsi dan faktor risiko serokonversi hepatitis C pada pasien yang menjalani HD di RS Cipto Mangunkusumo.

Metode. Penelitian potong lintang terhadap pasien yang menjalani HD di RS Cipto Mangunkusumo pada bulan Juni-Juli 2011. Pemeriksaan anti-HCV menggunakan Roche Elecsys ECLIA, Analisis multivariat menggunakan regresi logistik.

Hasil. Pada bulan Juni-Juli 2011 terdapat 135 pasien HD yang memenuhi kriteria …

Perubahan Status Fungsi Hati, Status Nutrisi, Kadar 3-Β-Hidroksi Butiran Darah, Dan Keseimbangan Nitrogen Pada Pasien Sirosis Hari Yang Menjalankan Puasa Ramadhan, Azzaki Abubakar, Irsan Hasan, Murdani Abdullah, Hamzah Shatri

Jurnal Penyakit Dalam Indonesia

Pendahuluan: Prevalensi sirosis cukup tinggi di Indonesia yang mayoritas populasinya adalah muslim. Pada saat menjalani puasa Ramadhan yang merupakan kewajiban umat muslim terjadi berbagai proses metabolik seperti penurunan glikokogenesis, peningkatan glukoneogenesis dan ketogenesis, dapat mempengaruhi keadaan klinis, nutrisi dan bokimiawi pasien sirosis hati yang juga mengalami proses hiperkatabolik. Penelitian tentang pengaruh puasa Ramadhan pada pasien sirosis hati di Indonesia belum pernah dilakukan. Berdasarkan kenyataan diatas perlu diteliti bagaimana perubahan terhadap status nutrisi, status fungsi hati, pembentukan badan keton dan keseimbangan nitrogen pada pasien sirosis hati yang menjalankan puasa Ramadhan.

Metode: Penelitian ini merupakan studi pre dan post, yang …

Hubungan Albumin Serum Awal Perawatan Dengan Perbaikan Klinis Infeksi Ulkus Kaki Diabetik Di Rumah Sakit Di Jakarta, Hendra Dwi Kurniawan, Em Yunir, Pringgodigdo Nugroho

Jurnal Penyakit Dalam Indonesia

Latar Belakang: Ulkus kaki diabetik terinfeksi merupakan kasus DM yang paling banyak dirawat di RS, berhubungan dengan morbiditas, mortalitas, biaya yang tinggi dan bersifat multifaktorial. Salah satu faktor yang berpengaruh adalah albumin. Belum ada penelitian yang secara langsung menghubungkan konsentrasi albumin serum awal perawatan dengan perbaikan klinis infeksi ulkus kaki diabetik. Belum ada batasan mengenai konsentrasi albumin yang dapat mempengaruhi perbaikan klinis infeksi ulkus kaki diabetik. Penelitian ini bertujuan Mendapatkan data mengenai konsentrasi albumin serum awal perawatan dan hubungannya dengan perbaikan klinis infeksi ulkus kaki diabetik. Metode: Penelitian dengan desain kohort prospektif terhadap 71 pasien diabetes dengan ulkus kaki terinfeksi …

Hipoglikemia: Sindrom Paraneoplastik Pada Karsinoma Hepatoselular, Hari Sutanto, Andra Aswar, N Soebijanto

Jurnal Penyakit Dalam Indonesia

Karsinoma hepatoselular (KHS) merupakan tumor ganas hati primer yang menempati urutan ketiga penyebab mortalitas akibat keganasan di seluruh dunia, karena acapkali terdiagnosis pada stadium lanjut. Tidak jarang manifestasi ekstrahepatik mucul pada KHS di antaranya hipoglikemia yang dapat muncul di akhir perjalanan penyakit ketika terjadi kegagalan fungsi hati; namun juga dapat muncul sebagai gejala awal sebelum ditemukan nodul pada hepar. Hipoglikemia dapat meningkatkan morbiditas, menurunkan kualitas hidup, dan menurunkan kesintasan. Pemahaman mengenai patogenesis, kewaspadaan serta diagnosis dini, dan penanganan yang tepat merupakan kunci tatalaksana utama.

Determinan Diagnostik Klinis Defisiensi Vitamin D Pada Wanita Berusia Lebih Dari 50 Tahun, Vera Vera, Siti Setiati, Arya Govinda

Jurnal Penyakit Dalam Indonesia

Pendahuluan: Prevalensi deifisiensi vitamin D pada wanita 50 tahun ke atas di Indonesia cukup tinggi namun pemeriksaan kadar vitamin D serum sangat mahal. Oleh karena itu, diperlukan alat penyaring defisiensi vitamin D yang cukup ekonomis dan sederhana untuk dikerjakan di layanan kesehatan primer. Metode: Penelitian ini merupakan penelitian diagnostik, menggunakan desain potong lintang (cross-sectional) sehubungan dengan pengambilan data hanya dilakukan sewaktu saja. Penelitian ini dilakukan di Kotamadia Bandung selama Agustus–Oktober 2012. Pada 240 subjek, dilakukan pengumpulan data berupa karakteristik responden, diabetes mellitus, penyakit ginjal kronik, riwayat jatuh, riwayat fraktur setelah menopause, nyeri tulang, skor paparan sinar matahari, skor proteksi sinar …