Medicine and Health Sciences Commons^™

Pulmonary Inflammation Is Regulated By The Levels Of The Vesicular Acetylcholine Transporter, Nathalia M. Pinheiro, Claudia J. C. P. Miranda, Adenir Perini, Niels O. S. Camara, Soraia K. P. Costa, Maria Isabel C. Alonso-Vale, Luciana C. Caperuto, Iolanda F. L. C. Tiberio, Marco A. M. Prado, Milton A. Martins, Vania F. Prado, Carla M. Prado

Anatomy and Cell Biology Publications

Acetylcholine (ACh) plays a crucial role in physiological responses of both the central and the peripheral nervous system. Moreover, ACh was described as an anti-inflammatory mediator involved in the suppression of exacerbated innate response and cytokine release in various organs. However, the specific contributions of endogenous release ACh for inflammatory responses in the lung are not well understood. To address this question we have used mice with reduced levels of the vesicular acetylcholine transporter (VAChT), a protein required for ACh storage in secretory vesicles. VAChT deficiency induced airway inflammation with enhanced TNF-alpha and IL-4 content, but not IL-6, IL-13 and …

Parental Consent Procedures: Impact On Response Rates And Nonresponse Bias, Diana M. Doumas, Susan Esp, Robin Hausheer

Counselor Education Faculty Publications and Presentations

This study examined the impact of passive versus active parental consent procedures on response rates and nonresponse bias when recruiting 9th grade students for a school-based alcohol intervention. Results indicated a significant difference in response rates when using passive parental consent procedures (91.8%) compared to active parental consent procedures (30.4%). Additionally, students recruited with active parental consent procedures reported lower rates of alcohol use and lower levels of alcohol-related consequences than those recruited with passive parental consent procedures. There were no differences in demographic variables between the two groups. Findings indicate active parental consent procedures may result in an underrepresentation …

Vital Sign In Healthcare: Are You Missing It?, Kae Van Engen

Faculty Work Comprehensive List

The ability to listen well, and to be deeply understood, enhances every aspect of our lives. The healthcare field is no different. This Work in Progress seeks to establish an ongoing dialogue.

Communicating With Patients And Their Families About Palliative And End-Of-Life Care: Comfort And Educational Needs Of Nurses, Cheryl Moir, Renee Roberts, Kim Martz, Judith Perry, Laura J. Tivis

Nursing Faculty Publications and Presentations

Introduction: Effectively discussing palliative care with patients and families requires knowledge and skill. The purpose of this study was to determine perceived needs of inpatient nurses for communicating with patients and families about palliative and end-of-life (EoL) care. Method: A non-experimental design was used. In total, 60 inpatient nurses from one hospital in Idaho completed the End of Life Professional Caregiver Survey (EPCS), which examines three domains: patient and family-centered communication, cultural and ethical values, and effective care delivery. Results: The number of years’ experience nurses had (F(9,131.57)=2.22, p=0.0246; Wilk's ^=0.709) and the unit they worked on (F(6,110)=2.49, p=0.0269; Wilk's …

Saving Money While Meeting Quality Targets In Latino Health Disparities: A Reason For Optimism, Claudia P. Santiago Md, Margaret Gallardo-Cochran Md, Luis Lopez Md, Betty Bohorquez Pa, Laura Gutierrez Md Facp Aahivm, Orlando Penaloza Md Facp Aahivm

Department of Medicine

No abstract provided.

Immune Function And Muscle Adaptations To Resistance Exercise In Older Adults: Study Protocol For A Randomized Controlled Trial Of A Nutritional Supplement, Richard A. Dennis, Usha Ponnappan, Ralph L. Kodell, Kimberly K. Garner, Christopher M. Parkes, Melinda M. Bopp, Kalpana P. Padala, Charlotte A. Peterson, Prasad R. Padala, Dennis H. Sullivan

Physical Therapy Faculty Publications

BACKGROUND: Immune function may influence the ability of older adults to maintain or improve muscle mass, strength, and function during aging. Thus, nutritional supplementation that supports the immune system could complement resistance exercise as an intervention for age-associated muscle loss. The current study will determine the relationship between immune function and exercise training outcomes for older adults who consume a nutritional supplement or placebo during resistance training and post-training follow-up. The supplement was chosen due to evidence suggesting its ingredients [arginine (Arg), glutamine (Gln), and β-hydroxy β-methylbutyrate (HMB)] can improve immune function, promote muscle growth, and counteract muscle loss. …

Ppm1a Regulates Antiviral Signaling By Antagonizing Tbk1-Mediated Sting Phosphorylation And Aggregation, Zexing Li, Ge Liu, Liwei Sun, Yan Teng, Xuejiang Guo, Jianhang Jia, Jiahao Sha, Xiao Yang, Dahua Chen, Qinmiao Sun

Markey Cancer Center Faculty Publications

Stimulator of interferon genes (STING, also known as MITA and ERIS) is critical in protecting the host against DNA pathogen invasion. However, the molecular mechanism underlying the regulation of STING remains unclear. Here, we show that PPM1A negatively regulates antiviral signaling by targeting STING in its phosphatase activity-dependent manner, and in a line with this, PPM1A catalytically dephosphorylates STING and TBK1 in vitro. Importantly, we provide evidence that whereas TBK1 promotes STING aggregation in a phosphorylation-dependent manner, PPM1A antagonizes STING aggregation by dephosphorylating both STING and TBK1, emphasizing that phosphorylation is crucial for the efficient activation of STING. Our …

Developing Integrate: A Fast And Frugal Patient-Reported Measure Of Integration In Health Care Delivery, Glyn Elwyn, Rachel Thompson, Roshen John, Stuart W. Grande

Dartmouth Scholarship

Efforts have been made to measure integration in health care delivery, but few existing instruments have adopted a patient perspective, and none is sufficiently generic and brief for administration at scale. We sought to develop a brief and generic patient-reported measure of integration in health care delivery. Drawing on both existing conceptualisations of integrated care and research on patients’ perspectives, we chose to focus on four distinct domains of integration: information sharing, consistent advice, mutual respect and role clarity. We formulated candidate items and conducted cognitive interviews with end users to further develop and refine the items. …

Gene Expression Analysis Of Upregulated Genes By 20-Oh Ecdysone In Brugia Malayi, Monica Lazaro

USF Tampa Graduate Theses and Dissertations

Brugia malayi is a filarial nematode causing lymphatic filariasis in humans characterized by swelling of the lower extremities. The aim of this study was to conduct a real time PCR (qRT-PCR) to verify gene expression levels of Brugia malayi nematodes treated with 20 hydroxyecdysone. Transcriptome analysis was previously performed resulting in the identification of 44 genes that were upregulated by exposure to 20-hydroxyecdysone. Based on transcriptome results, known GO Terms and functions, four genes and one endogenous housekeeping gene were chosen for validation by RT-PCR. Induced samples showed a mean increase of microfilarie by 2.2 fold. Induced wells exhibited a …

Maternal Analgosedation And Breastfeeding: Guidance For The Pediatrician, Karel Allegaert, Johannes N. Van Den Anker

Surgery Faculty Publications

As part of analgosedative treatment modalities after delivery (e.g. caesarean related pain, birth related trauma, pre-existing pain syndromes), mothers are treated with different analgosedatives that may also affect the nursing infant. This review aims to summarize the available knowledge on commonly prescribed analgosedatives (opioids, intravenous and inhalational anesthetics, benzodiazepines, non-opioid analgesics, and local anesthetics) during breastfeeding.

We propose that the use of systemic non-opioid analgesics, local anesthetics, inhalational or intravenous anesthetics is safe when mothers are nursing. When systemic opioids are used, we recommend pediatricians to consider clinical monitoring of the infant for sedation. The duration of maternal exposure ( …

Low Dose Aspirin: An Effective Chemoprophylaxis For Preventing Venous Thromboembolic Events, Javad Parvizi, Md, Frcs, Antonia F. Chen, Md, Mba, Camilo Restrepo, Md, Ronald Huang, Md, Jenny Cal, Bs, William J. Hozack, Md, Jess H. Lonner, Md

Rothman Institute Conference Posters

The available guidelines, endorsed by Surgical Care Improvement Project (SCIP), have advocated that aspirin (ASA) is a safe and eff­ective strategy for venous thromboembolic events (VTE) prophylaxis following total joint arthroplasty (TJA). The optimal dose of aspirin for this purpose is not known. The first guidelines for prevention of VTE that were issued by the American Academy of Orthopedic Surgeons recommended 325 mg Bis in die (twice a day) (bid) for this purpose with the recommendation having a 1C grade (little evidence to support the recommendation). It is known that platelet aggregation inhibition occurs at lower doses. Traditionally, ASA 81mg …

Maternal Nicotine Exposure Leads To Impaired Disulfide Bond Formation And Augmented Endoplasmic Reticulum Stress In The Rat Placenta, Michael Wong, Catherine J. Nicholson, Alison C. Holloway, Daniwl Hardy

Physiology and Pharmacology Publications

Maternal nicotine exposure has been associated with many adverse fetal and placental outcomes. Although underlying mechanisms remain elusive, recent studies have identified that augmented endoplasmic reticulum (ER) stress is linked to placental insufficiency. Moreover, ER function depends on proper disulfide bond formation-a partially oxygen-dependent process mediated by protein disulfide isomerase (PDI) and ER oxidoreductases. Given that nicotine compromised placental development in the rat, and placental insufficiency has been associated with poor disulfide bond formation and ER stress, we hypothesized that maternal nicotine exposure leads to both placental ER stress and impaired disulfide bond formation. To test this hypothesis, female Wistar …

Red Cell Distribution Width: An Unacknowledged Predictor Of Mortality And Length Of Stay Following Revision Arthroplasty, Pouya Alijanipour, Md, Snir Heller, Md, Fatih Kucukdurmaz, Md, Benjamin Zmistowski, Md, Maryam Rezapoor, Ms, Javad Parvizi, Md, Frcs

Rothman Institute Conference Posters

Introduction

Red blood cell distribution width (RDW), a measure of variability in size of circulating erythrocytes, is routinely reported in complete blood cell analysis, and together with mean cell volume (MCV) has conventionally been used to distinguish the cause of anemia. It is calculated by (Standard deviation of MCV÷ mean MCV) x 100, with normal range being 11.5%-14.5%. Several recent publications have described RDW as an independent predictor of adverse outcome and mortality in patients with different underlying medical conditions such as acute and chronic heart failure, peripheral artery disease, chronic pulmonary disease and acute kidney injury1. The purposes of …

Radiation Exposure To The Eye With Mini C-Arm Use During Hand Surgery, Mark L. Wang, Md, Phd, C. Edward Hoffler, Md, Phd, Frederick E. Liss, Md, Asif Ilyas, Md, Charles Leinberry, Md, Pedro Beredjiklian, Md

Rothman Institute Conference Posters

Introduction:

Fluoroscopic radiation exposure is a potential occupational health risk to the Hand Surgeon, given operator proximity and the relative lack of eye shielding. The association of eye radiation exposure and the early development of cataracts have been previously reported. Mini C-arm fluoroscopy is commonly utilized during routine Hand Surgery. At present, the amount of radiation exposure to the eye, associated with the routine use of mini C-arm fluoroscopy, is unknown, thus warranting further investigation. The purpose of this study is to test the hypothesis that eye radiation exposure, sustained during routine mini C-arm use, does not exceed that of …

Connecting Preparedness Science With The National Health Security Preparedness Index: Research Translation Opportunities, Glen P. Mays

Health Management and Policy Presentations

The National Health Security Preparedness Index is a mechanism for applying advances in preparedness measurement and analysis from Hurricane Sandy research projects to advance policies and practices in preparing for, responding to, and recovering from disasters and other health emergencies

The National Health Security Preparedness Index: Harnessing Evidence & Experience To Drive Improvement, Glen P. Mays

Health Management and Policy Presentations

This presentation profiles the National Health Security Preparedness Index as a mechanism for measuring preparedness and resiliency levels across the U.S. Forthcoming enhancements in measurement and analytic methodologies will allow the Index to play heightened roles in informing policies and practices that protect the U.S. population from a broad range of hazards.

The Use Of Teamstepps® In The Development And Implementation Of Staff Nurse Councils, Katreena Collette Merrill

Journal of Undergraduate Research

1. TeamSTEPPS training: As a result of this project, 395 number of students received training on TeamSTEPPS. Students created case studies and role play videos about communication in healthcare.
2. In addition to the effect on the senior undergraduate nursing students and family nurse practitioner graduate students, we were able to implement TeamSTEPPS into a new interprofessional education course STDEV 214R.
3. As a result of this project, we were contacted by the Agency for Healthcare Research Quality for an interview on how we have applied TeamSTEPPS. Results of the interview will be posted on the web site in 2015 citing Brigham Young …

Metformin Prevents Aggressive Ovarian Cancer Growth Driven By High-Energy Diet: Similarity With Calorie Restriction, Zaid Al-Wahab, Ismail Mert, Calvin Tebbe, Jasdeep Chhina, Miriana Hijaz, Robert T. Morris, Rouba Ali-Fehmi, Shailendra Giri, Adnan Munkarah, Ramandeep Rattan

Department of Obstetrics and Gynecology Research Publications

Caloric restriction (CR) was recently demonstrated by us to restrict ovarian cancer growth in vivo. CR resulted in activation of energy regulating enzymes adenosine monophosphate activated kinase (AMPK) and sirtuin 1 (SIRT1) followed by downstream inhibition of Akt-mTOR. In the present study, we investigated the effects of metformin on ovarian cancer growth in mice fed a high energy diet (HED) and regular diet (RD) and compared them to those seen with CR in an immunocompetent isogeneic mouse model of ovarian cancer. Mice either on RD or HED diet bearing ovarian tumors were treated with 200 mg/kg metformin in drinking …

If We Knew Then What We Know Now: Lessons Learned In Managing Two Academic Health Science Institutional Repositories, Daniel G. Kipnis, Msi, Lisa A. Palmer, Msls, Ahip

Academic Commons and Scott Memorial Library Staff Papers and Presentations

Poster presented at ACRL annual conference in Portland Oregon.

Time: 2:00 PM - 3:00 PM

Location: Exhibit Hall - Poster 27

Evidence For The Inhibition Of Dengue Virus Binding In The Presence Of Silver Nanoparticles, Kelley J. Williams

Theses and Dissertations

Dengue is an emerging hemorrhagic fever virus and widely considered the most important arbovirus in the world. Dengue virus (DENV) is a positive-sense RNA virus that exists in 4, potentially 5, antigenic serotypes. Currently, no vaccines or treatments are approved for DENV infections. Unsuccessful vaccine trials open the door for non-traditional treatments such as silver nanoparticles. Silver nanoparticles (AgNP) are known to inhibit viral replication of numerous viruses but have never before been tested for inhibition of dengue virus type 2 (DENV2, ATCC® VR-1584^TM). For the first time, this research presents up to a 96% reduction in DENV2 …

Enhanced Light Trapping By Metallic Nanorod Arrays For Organic Photovoltaic Cells, Rosure Borhanalden Abdulrahman

Theses and Dissertations

Metallic nanostructures can exhibit different optical properties compared to bulk materials mainly depending on their shape, size, and separation. Vertically aligned arrays of aluminum (Al) nanorods of different lengths and morphologies were fabricated by DC sputtering using the glancing angle deposition (GLAD) method. Detailed structural and optical properties of GLAD Al nanorod were investigated and compared to those of conventional flat Al thin film coatings. Optical characterization results show that total reflectance is inversely proportional to nanorod length in the wavelength range 200-1800 nm, due to the enhanced surface plasmon resonance and light trapping among the nanorods. In addition, we …

The ‘Ohana Mana Challenge: An Intervention Study On Native Hawaiian And Pacific Islander Nutrition And Activity, Jane H. Lassetter

Journal of Undergraduate Research

In our recent study, 84.4% of Native Hawaiian and Pacific Islanders (NHPIs) in Hawaii and Utah were overweight or obese, which puts them at increased risk for obesity-related diseases, including cardiovascular disease, diabetes, and some cancers. Pre-colonization NHPI diets were rich in fresh fruits and vegetables and fish, but research indicates current NHPI diets consist largely of processed and fast foods. Along with this change in NHPI diet came a change in activity, from fishing and farming to more sedentary jobs. The changes in diet and activity likely contribute to high NHPI overweight and obesity prevalence. People can make wise …

The Significance Of Whole Grain Teff For Improving Nutrition: From Injera To Ready To Eat Porridge By Using Extrusion Cooking Technology, Helen T. Zewdie, Mammo Muchie

International Journal of African Development

Teff (EragrostisTef) is a fascinating grain, ancient, minute in size, packed with nutrition and used for centuries as the principal ingredient of the Ethiopian population diet. The micro- and macronutrients level of teff grainis apparently higher than that of barley, wheat and sorghum and the amino acid composition comparable to that of egg protein, except for its lower lysine content. In Ethiopia, it has been using as a staple food by making flat bread called Injera. Teff can be diversified from its current provision of Injera to other forms like instant porridge to improve the nutritional quality and it may …

Rear-Facing Child Car Seats: Are Laws Requiring Them Effective?, Eli Friedman, Henry J. Carretta, Joshua Jordan, Leslie M. Beitsch

Frontiers in Public Health Services and Systems Research

Introduction: Motor vehicle crashes are a leading cause of death in children aged ≤ 2 years in the U.S. The American Academy of Pediatrics advised that children should remain in rear-facing child car seats to mitigate injury from the most common type of severe collision (frontal). Several states have passed laws following these recommendations.

Methods: In 2013 publicly available statutes and comprehensive motor vehicle fatality data from the National Highway Traffic Safety Administration’s Fatality Analysis Reporting System database were used to investigate whether there is a relationship between motor vehicle crash fatality rates for children under 1 year of age …

Answering The Call To Integrate: Simple Strategies From Public Health And Healthcare Executives In One Urban County, Erik L. Carlton, Paul C. Erwin

Frontiers in Public Health Services and Systems Research

Background: As the Affordable Care Act transforms the practice of both public health and health care, it also provides opportunity for both to become more closely linked through improved integration and collaboration. Yet, while public health agencies are increasingly called to work with healthcare partners to address population health needs, both public health leaders and their healthcare counterparts may not be well equipped to answer that call. Although recent studies have begun exploring the collaborative strategies and capacity of public health system partners, there is still much to learn. The purpose of this study was to identify, through the perspective …

Accreditation Intent, Community Health Assessments, And Local Health Department–Hospital Collaboration, Erik L. Carlton, Simone Singh

Frontiers in Public Health Services and Systems Research

Background: Community health assessments (CHAs) are among the most core of activities conducted by local health departments (LHDs), and many LHDs have been conducting CHAs on a regular basis for years. More recently, completing a CHA has also become a prerequisite for LHDs seeking accreditation by the Public Health Accreditation Board (PHAB). Similarly, under the Affordable Care Act, tax-exempt hospitals are required to conduct periodic community health needs assessments. Opportunities thus exist for LHDs and tax-exempt hospitals to engage in collaborations related to CHAs. Yet, it remains unclear whether interest in PHAB accreditation provides incentive to LHDs to engage in …

The Purpose And Value For Students Of Pbl Groups For Learning, Vicki J. Skinner, Annette Braunack-Mayer, Tracey A. Winning

Interdisciplinary Journal of Problem-Based Learning

Groups are central to problem-based learning (PBL) and educational and professional outcomes relevant to clinical education. However, PBL groups in practice may differ from theoretical conceptions of groups. Therefore, this study explored students’ understandings of the purpose and value of PBL groups for their learning. We conducted a naturalistic study with novice (first-year) students at two dental schools (Australia, Ireland), using observation and interviews analyzed thematically. Students constructed PBL learning as individual knowledge gain, and group purpose as information gathering and exchange; few students acknowledged the learning potential of group processes. Group value depended on assessment and curriculum context. Findings …

The Use Of Pbl In An Interprofessional Education Course For Health Care Professional Students, Kristine M. L'Ecuyer, David Pole, Sheila A. Leander

Interdisciplinary Journal of Problem-Based Learning

A problem-based learning (PBL) framework was utilized in a series of six interprofessional team seminars (IPTS) for postbaccalaureate students from seven health professions. The goal of IPTS was to develop a collaborative practice-ready workforce prepared to respond to patient care needs through use of concrete examples, skills development, critical thinking, and problem solving in safe, faculty-facilitated small groups. The collaborative nature of PBL closely correlates with teaching methodologies of the IPTS series. This study analyzed critical reflection assignments of nursing students in accelerated programs to determine the effectiveness of IPTS at preparing students for interprofessional collaborative practice. Findings indicated that …

Guest Editors’ Introduction: Special Issue On Problem-Based Learning In Health Professions Education/Toward Advancement Of Problem-Based Learning Research And Practice In Health Professions Education: Motivating Learners, Facilitating Processes, And Supporting With Technology, Xun Ge, Lourdes G. Planas, Kun Huang

Interdisciplinary Journal of Problem-Based Learning

No abstract provided.

Sincerely, The Quiet Girl, Brianna Dipanni

SURGE

When I was younger, I used to think there was something horribly wrong with me, as if I had this mortal flaw. Some nights I used to lie awake in bed and just stare at the flickering red numbers of my bedside clock, wondering to myself when things would change. How long would it take to overcome my quiet phase? When will I finally be normal? [excerpt]