Medicine and Health Sciences Commons^™

Pkcε Is An Essential Mediator Of Prostate Cancer Bone Metastasis., Alvaro Gutierrez-Uzquiza, Cynthia Lopez-Haber University Of Pennsylvania, Danielle L. Jernigan, Alessandro Fatatis, Marcelo G. Kazanietz

Kimmel Cancer Center Papers, Presentations, and Grand Rounds

UNLABELLED: The bone is a preferred site for metastatic homing of prostate cancer cells. Once prostate cancer patients develop skeletal metastases, they eventually succumb to the disease; therefore, it is imperative to identify key molecular drivers of this process. This study examines the involvement of protein kinase C epsilon (PKCε), an oncogenic protein that is abnormally overexpressed in human tumor specimens and cell lines, on prostate cancer cell bone metastasis. PC3-ML cells, a highly invasive prostate cancer PC3 derivative with bone metastatic colonization properties, failed to induce skeletal metastatic foci upon inoculation into nude mice when PKCε expression was silenced …

Review Of The Pe Metrics Cognitive Assessment Tool For Fifth Grade Students, Michael Hodges, Chong Lee, Kent A. Lorenz, Daniel Cipriani

Physical Therapy Faculty Articles and Research

Study aim: this study examined the item difficulty and item discrimination scores for the HRFK PE Metrics cognitive assessment tool for 5th-grade students. Materials and methods: ten elementary physical education teachers volunteered to participate. Based on convenience, participating teachers selected two 5th grade physical education classes. Teachers then gave students (N = 633) a 28-question paper and pencil HRFK exam using PE Metrics Standards 3 and 4. Item difficulty and discrimination analysis and Rasch Modeling were used data to determine underperforming items. Results: analysis suggests that at least three items are problematic. The Rasch Model confirmed this …

Less Is More: The Physiological Basis For Tapering In Endurance, Strength, And Power Athletes, Kevin A. Murach, James R. Bagley

Physical Therapy Faculty Publications

Taper, or reduced-volume training, improves competition performance across a broad spectrum of exercise modes and populations. This article aims to highlight the physiological mechanisms, namely in skeletal muscle, by which taper improves performance and provide a practical literature-based rationale for implementing taper in varied athletic disciplines. Special attention will be paid to strength- and power-oriented athletes as taper is under-studied and often overlooked in these populations. Tapering can best be summarized by the adage “less is more” because maintained intensity and reduced volume prior to competition yields significant performance benefits.

Complete Genome Sequence Of Noncytopathic Bovine Viral Diarrhea Virus 1 Contaminating A High-Passage Rk-13 Cell Line, Bora Nam, Ganwu Li, Ying Zheng, Jianqiang Zhang, Kathleen M. Shuck, Peter J. Timoney, Udeni B. R. Balasuriya

Maxwell H. Gluck Equine Research Center Faculty Publications

A high-passage rabbit kidney RK-13 cell line (HP-RK-13[KY], originally derived from the ATCC CCL-37 cell line) used in certain laboratories worldwide is contaminated with noncytopathic bovine viral diarrhea virus (ncpBVDV). On complete genome sequence analysis, the virus strain was found to belong to BVDV group 1b.

Recurrent Streptococcus Equi Subsp. Zooepidemicus Bacteremia In An Infant, Joshua R. Watson, Amy Leber, Sridhar Velineni, John F. Timoney, Monica I. Ardura

Maxwell H. Gluck Equine Research Center Faculty Publications

We describe a case of an infant with recurrent bacteremia caused by Streptococcus equi subsp. zooepidemicus, likely transmitted from mother to infant. Our case highlights the importance of an epidemiological history and molecular diagnostics in ascertaining insights into transmission, pathogenesis, and optimal management.

The Effects Of Massage On Perceived Physical Soreness, Pain And Markers Of Inflammation Following High Intensity Unaccustomed Exercise, Courtney Lynn Crow

Master's Theses

Massage is often recommended to athletes to facilitate recovery and attenuate DOMS. The purpose of this study was to investigate the effects of massage on perceived muscle soreness and pain, inflammatory and immune markers, ROM, and mood state. Fourteen, recreationally active, women participated in a randomized crossover design study, consisting of 1) 60 min. full body massage following unaccustomed exercise and 2) 60 min. of rest. following unaccustomed exercise. Perceived muscle soreness and pain, active range of motion (ROM), mood state, along with blood concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), creatine kinase (CK), and neutrophil count (NC), was assessed …

Novel Human Abcc9/Sur2 Brain-Expressed Transcripts And An Eqtl Relevant To Hippocampal Sclerosis Of Aging, Peter T. Nelson, Wang-Xia Wang, Bernard R. Wilfred, Angela Wei, James Dimayuga, Qingwei Huang, Eseosa T. Ighodaro, Sergey C. Artiushin, David W. Fardo

Sanders-Brown Center on Aging Faculty Publications

ABCC9 genetic polymorphisms are associated with increased risk for various human diseases including hippocampal sclerosis of aging. The main goals of this study were 1 > to detect the ABCC9 variants and define the specific 3′ untranslated region (3′UTR) for each variant in human brain, and 2 > to determine whether a polymorphism (rs704180) associated with risk for hippocampal sclerosis of aging pathology is also associated with variation in ABCC9 transcript expression and/or splicing. Rapid amplification of ABCC9 cDNA ends (3′RACE) provided evidence of novel 3′ UTR portions of ABCC9 in human brain. In silico and experimental studies were performed focusing on …

Beyond Normative Ethics: Ethics Of Arts-Based Disability Research = Au-Delà De L’Éthique Normative : Déontologies De La Recherche Provenant Du Disability Arts, Roxanne Mykitiuk, A. Chaplick, C. Rice

Articles & Book Chapters

In Western culture, the pervading medical model of disability has characterized disability as a problem in need of a solution: an unwanted condition that demands a cure. Even the word “disability” is unavoidably negative: structurally it signifies a loss or a lack, a state that exists only because it falls short of something better. Contrary to mainstream thinking, disability is not a natural state of inferiority or a stroke of misfortune; rather, disability is a culturally fabricated narrative of embodiment. As Scully (2008) observes, representations of disability, created in the main by non-disabled people, tell normative bodies what they want …

Reinventing American Health Care: How The Affordable Care Act Will Improve Our Terribly Complex, Blatantly Unjust, Outrageously Expensive, Grossly Inefficient, Error Prone System By E. Emmanuel (Review), Rebecca B. Yarrison

Internal Medicine Faculty Publications

No abstract provided.

We Can Do Better: An Argument For Improved Care Of The Opioid Addicted Mother-Infant Dyad, Michele K. Savin, Msn, Nnp-Bc

College of Nursing Faculty Papers & Presentations

As the number of addicted maternal-infant dyads increases, so does the need for nursing to expand its understanding of the addiction process and the evidencebased interventions that best serve mothers and infants. Nursing attitudes toward the opioid-addicted mother and infant dyad are influenced by knowledge deficits and communication difficulties. Care required encompasses medical, legal, social, and economic perspectives. Professionals and society at large have disagreements regarding whether to approach the phenomenon from a punitive or supportive strategy. Facilities to care for the mother-infant dyad with addiction are limited. Increasing knowledge has great potential for active understanding and ability to impact …

If You’Ve Seen One Worm, Have You Seen Them All? Spatial, Community, And Genetic Variability Of Tubificid Communities In Montana, Nilanjan Lodh, Donna M. Rizzo, Billie L. Kerans, Stephanie Mcginnis, Nikolaos Fytilis, Lori Stevens

Clinical Lab Sciences Faculty Research and Publications

Genetic studies are recognized increasingly as important for understanding naturally occurring disease dynamics and are used to predict host genetic diversity and coevolutionary processes and to identify species composition in ecological communities. Tubifex tubifex, the definitive host of the whirling disease parasite Myxobolus cerebralis, comprises 6 known lineages that vary widely in parasite susceptibility. We used 16S ribosomal DNA (16S rDNA) to identify relationships among genetic variability of 3 oligochaete genera (T. tubifex, Rhyacodrilus spp., and Ilyodrilus spp.; Oligochaeta:Tubificidae), oligochaete assemblage composition, and the presence of whirling disease in 9 locations across 4 watersheds in Montana, …

Nutrinews Volume 9, September 2015, Department Of Nutrition And Dietetics, University Of North Florida

NutriNews

This issue features Graduate Student View, The Fad Finder, The Lunch box, From our faculty, From the Academy

Are Bone Turnover Markers And Vitamin D Levels Associated With Frequency Of Complete Denture Relines?, Shweta Puri

Loma Linda University Electronic Theses, Dissertations & Projects

PURPOSE: To compare groups of subjects with varying frequencies of complete denture relines in terms of their bone turnover markers; C-terminal Telopeptide (C-Tx), Osteocalcin (OCN) and Vitamin D (25 OH-Vit D) levels to determine the presence of and the degree of association between them.

METHODS: This study was designed as a cross-sectional study wherein a retrospective chart review of three hundred twenty four edentulous subjects with history of complete denture use for at least a year was performed to determine history and frequency of their complete denture relines. A total of 100 patients were enrolled. After consent was obtained, each …

The Effects Of A Novel Therapeutic Intervention In Diabetic Peripheral Neuropathy Patients, Adel M. Alshahrani

Loma Linda University Electronic Theses, Dissertations & Projects

Diabetes mellitus (DM) is a common disorder affecting individuals in the United States and in the world. The prevalence of DM has increased noticeably over the last three decades with an estimated 380 million people currently diagnosed with this disease. DM is associated with numerous systemic complications that affect the retina, heart, brain, kidneys, and nerves. The most common complication of DM is diabetic peripheral neuropathy. Diabetic peripheral neuropathy causes reduced sensation, reflexes, proprioception, and strength in lower limbs that leads to balance problems. Various manual therapy techniques have not approached a pilot study for the efficacy of a manual …

Developing Dyadic Measurements In Marriage And Family Therapy: The Dyadic Supervision Evaluation, Adrian Avila

Loma Linda University Electronic Theses, Dissertations & Projects

This study applies integrative developmental theory and a common factors approach in evaluating and describing how Marital and Family Therapy trainee’s progress in mastering the core competencies set forth by the Commission on Accreditation for Marriage and Family Therapy Education (COAMFTE) through the process of clinical supervision. More specifically, this project evaluates the internal reliability, construct validity, and predictive validity of the Dyadic Supervision Evaluation (DSE). The important role and influence of clinical supervision as well as the next steps for validating and evaluating dyadic, developmental, core competencies and common factors measurements in clinical supervision are discussed.

The Lived Experience Of Aging: Listening To The Oldest-Old, Julia A. Pusztai

Loma Linda University Electronic Theses, Dissertations & Projects

Although embraced as desirable by most, living into very old age is largely unexplored as a distinct season of life, with increased, varied, and cumulative changes during a unique time of vulnerability and frailty. The purpose of this study was to listen to the oldest-old, and to explore their lived experience of growing old. This hermeneutic phenomenology study examines the experience of finding meaning and living with losses and gains in advanced old age. This study design included three separate interviews one month apart with participants over 85 years of age. Purposive sampling resulted in 13 participants, 5 being male …

Tooth Size Ratio In Orthodontic Patients With Varied Sagittal Skeletal Patterns; A Cbct Study, James Barra

Loma Linda University Electronic Theses, Dissertations & Projects

Objective: Maxillomandibular tooth size ratio (TSR) is an important aspect in achieving a satisfactory orthodontic outcome. The purpose of this study is to compare TSR among orthodontically treated patients with different skeletal anteroposterior (AP) patterns. Methods and Materials: The post-treatment (T2) cone beam computed tomograms (CBCTs) of patients treated orthodontically without extraction and finished with canine and molar class I occlusion were evaluated. The subjects were categorized into class I, class II and class III skeletal pattern by analyzing A point-Nasion-B point (ANB) at T2. Overbite (OB), overjet (OJ), TSR for canine to canine (TSR3-3) and molar to molar (TSR6-6), …

The Effect Of Scan Settings On The Identification Of Tooth Socket Lamina Dura Surface: A Cbct Study, Erick Carlucci

Loma Linda University Electronic Theses, Dissertations & Projects

Aim: Cone-beam computed tomography (CBCT) is becoming a common adjunct in orthodontic diagnosis and treatment, however several questions remain about the impact of surrounding anatomical structures and varying scan settings on the ability to delineate buccal bone and overall diagnostic quality of images produced. The aim of this study was to determine if adjacent structures with similar radiodensity and variable scan settings (field of view and voxel size) significantly impact the ability to accurately identify the tooth socket facial lamina dura, facial bone surface, facial bone margin, as well as the facial bone thickness measurement. Materials & Methods: CBCT scans …

Tooth Length Measurements On 3t Mr Images: A Retrospective Study, Kevin G. Murray

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: The purpose of this study was to determine if MRI can be used to accurately measure tooth lengths. Methods: MRI tooth length measurements were compared with “actual tooth lengths” as measured on CBCT scans. Twenty three subjects received two scans (one CBCT and one MRI). Tooth length was measured and compared between the resultant images. Intraclass correlations were used for statistical analysis. Results: Tooth length measurements made on MRI scans showed moderate to almost perfect agreement with tooth length measurements made on CBCT scans. Higher levels of agreement were present in the maxillary arch compared to the mandibular arch. …

Dietary Intake And Bio-Activation Of Nitrite And Nitrate In Newborn Infants, Jesica Ann Jones

Loma Linda University Electronic Theses, Dissertations & Projects

Nitrate and nitrite are commonly thought of as inert end products of nitric oxide (NO) oxidation, possibly carcinogenic food additives, or well-water contaminants. However, recent studies have shown that nitrate and nitrite play an important role in cardiovascular and gastrointestinal homeostasis through conversion back into NO via a physiological system involving enterosalivary recirculation, bacterial nitrate reductases, and enzyme-catalyzed or acidic reduction of nitrite to NO. The diet is a key source of nitrate in adults; however, infants ingest significantly less nitrate due to low concentrations in breast milk. In the mouth, bacteria convert nitrate to nitrite, which has gastro-protective effects. …

Effect Of Diamond Bur And Root Canal Irrigants On Retention Of Fiber Posts, Rami Jekki

Loma Linda University Electronic Theses, Dissertations & Projects

Esthetic glass fiber-reinforced posts are being used more often. The most commonly reported complication associated with these posts is debonding. Dentine conditioning with solutions such as EDTA or MTAD results in removal of smear layer and might improve the retention of posts to root canal dentin. Therefore, the purpose of this study was to investigate the effect of cleansing the post space with MTAD or EDTA on the bond strength of glass fiber-reinforced posts, when a diamond roughening instrument is used prior to cementation with self-adhesive resin cement. Forty-five (n=15) extracted human premolar teeth were sectioned at the cemento-enamel junction …

Program Evaluation And Guideline Development For Psychological Treatment Of The Adolescent And Young Adult Population With Cancer, Kayla R. Kraich

Loma Linda University Electronic Theses, Dissertations & Projects

The adolescent and young adult (AYA) cancer population suffers from many unique medical and mental health challenges. Both medical, psychological and support services play an important role in the lack of improvement in survival rates of this population. The purpose of this project was to identify the unique mental health challenges and treatment needs of the Adolescent and Young Adult (AYA) Oncology population and to evaluate current oncology programs available to this population at Loma Linda University. The project provides guideline recommendations for implementing a comprehensive and developmentally appropriate AYA oncology program at Loma Linda University.

Music Listening As Therapy, David M. Rosenblatt

Loma Linda University Electronic Theses, Dissertations & Projects

Music is a universal phenomenon and is a real, physical thing. It is processed in neural circuits that overlap with language circuits, and it exerts cognitive, emotional, and physiological effects on humans. Many of those effects are therapeutic, such as reduced symptoms of physical and mental ailments. Music is the result of the elements rhythm, melody, harmony, timbre, dynamics, and form. Rhythm is the focus of pop music, and melody is the focus of classical music. The mind perceives and organizes music in learned, consistent ways in order to generate predictions and extract meaning. There are perceptual laws and information …

Palmitic Acid Activation Of Dendritic Cells: Implications For Type 2 Diabetes, Dequina Angelina Nicholas

Loma Linda University Electronic Theses, Dissertations & Projects

Infiltration of immune cells into visceral adipose tissue is observed in type 2 diabetes development. Monocytes are recruited to obese visceral adipose tissue in large numbers and retain the ability to differentiate into dendritic cells, important antigen presenting cells in the immune system. Differentiation of monocytes into dendritic cells likely accounts for the increased number of dendritic cells observed in the adipose tissue of type 2 diabetic patients. We have demonstrated this differentiation process is regulated in part by a major reduction of linker histone proteins. In adipose tissue, dendritic cells are exposed to high levels of saturated fatty acids. …

Treatment Outcomes Of Patients With Unilateral Class Ii Malocclusions: A Cbct Study, Brent Leggett

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: The purposes of this study were to determine the prevalence of Class II (Cl II) subdivision patients, to quantify the change in TMJ complex, and mandibular length after treatment was accomplished. Materials and Methods: Records of consecutive patients who sought orthodontic treatment at Loma Linda University (LLU) were screened. Only patients with dental Cl II subdivision that had completed treatment with pre- (T1) and post-treatment (T2) cone beam computed tomograms (CBCTs) available were evaluated for changes in the TMJ complex position related to Foramen Rotundum (TMJ-FR), joint spaces and mandibular length (condylion to genial tubercles). Comparisons were made between …

Physical Therapy After Triangular Fibrocartilage Injuries And Ulnar Wrist Pain, Mohamed A. Abdelmegeed

Loma Linda University Electronic Theses, Dissertations & Projects

Background: The ulnar side of the wrist has been referred to as the “black box” of the wrist because of its complex structures and sophisticated anatomy, disorders at this anatomical site have been compared to those of low back pain

Purposes: The purpose of this study was to apply the Brief International Classification of Functioning (ICF) Core Set for Hand Conditions to the physical therapy outcome measures, and to evaluate the contribution of these measures to overall health in subjects with ulnar wrist pain. A secondary purpose was to investigate the effect of wrist orthotics and strengthening exercise on …

Morphological Changes In Alveolar Bone Following Orthodontic Space Closure, Ninette Hacopian

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: Changes occurring in anterior alveolar bone following orthodontic tooth movement are controversial. Some research has shown that orthodontic tooth movement results in the adaptation of cortical bone; others have shown that it results in dehiscence and fenestrations.

Purpose: The purpose of this study was to evaluate the alveolar bone changes around maxillary anterior teeth following orthodontic space closure.

Materials and Methods: Cone beam computed tomograms (CBCTs) of non-growing patients who received orthodontic treatment with bilateral maxillary premolar extraction were evaluated. Only patients with at least 5 degrees of changes in maxillary incisor (U1) to palatal plane angle were included …

Comparison Of Maxillary Anterior Teeth Width To Facial Dimensions Among Three Races, Ewa Parciak

Loma Linda University Electronic Theses, Dissertations & Projects

Dental esthetics and tooth proportions have become increasingly relevant in dentistry, as the cosmetic demands of patients increase. Determining the appropriate esthetic dimensions of the maxillary anterior teeth is an important aspect in fixed and removable prosthodontics. The proportion of facial structures and the relationship between facial measurements and natural teeth could provide additional guidance in selecting denture teeth as well as in determining ideal teeth size for fixed restorations. There have been many publications on this topic, however, the subjects in these studies have been mostly selected from the Caucasian race. With the increasing diversity of the American population …

Unconditional Cash Transfers For Assistance In Humanitarian Disasters: Effects On The Use Of Health Services And Health Outcomes In Low- And Middle-Income Countries, Frank Pega, Sze Yan Liu, Stefan Walter, S K. Lhachimi

Department of Public Health Scholarship and Creative Works

BACKGROUND:

Unconditional cash transfers (UCTs) are a common social protection intervention that increases income, a key social determinant of health, in disaster contexts in low- and middle-income countries (LMICs).

OBJECTIVES:

To assess the effects of UCTs in improving health services use, health outcomes, social determinants of health, health care expenditure, and local markets and infrastructure in LMICs. We also compared the relative effectiveness of UCTs delivered in-hand with in-kind transfers, conditional cash transfers, and UCTs paid through other mechanisms.

SEARCH METHODS:

We searched 17 academic databases, including the Cochrane Public Health Group Specialised Register, the Cochrane Database of Systematic Reviews …

Modifiable Risk Factors In Patients With Cerebrovascular Accident, Sher Ali Khan, Mir Jalal-Ud-Din, Raheel Ahangir Jadoon, Shawana Asad, Rashid Ali, Muhammad Saqib Saeed

Pakistan Journal of Neurological Sciences (PJNS)

To determine the frequency of modifiable risk factors of stroke. Study Design: Descriptive Case series. Place and duration of study: Ayub Teaching Hospital, Abbottabad from March to December 2012. Methodology: 106 cases of cerebrovascular accident (CVA) above 20 years of age and of either sex admitted in medical units of Ayub Teaching Hospital, Abbottabad were included in this study. The patients below 20 years of age, those with recurrent history of CVA, patients not fulfilling the required criteria of risk factors set in operational definitions and patients having intracranial space occupying lesion such as tumors or brain abscess or neurological …