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2015

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Articles 2341 - 2370 of 11981

Full-Text Articles in Medicine and Health Sciences

Early Childhood Development And The Social Determinants Of Health Inequities: A Review Of The Evidence, Tim Moore, Myfanwy Mcdonal, Harriet Mchugh-Dillon Sep 2015

Early Childhood Development And The Social Determinants Of Health Inequities: A Review Of The Evidence, Tim Moore, Myfanwy Mcdonal, Harriet Mchugh-Dillon

Mickey Leland Center Information Portal

This report focuses on early childhood development and the social determinants of health inequities. It is one of eight reviews of evidence commissioned by VicHealth to support the use of a planning tool for health promotion policy and practice in Victoria, known as Fair Foundations.


Plasminogen Activator Inhibitor-1 Inhibitors And Methods Of Use Thereof To Modulate Lipid Metabolism, Daniel A. Lawrence, Cory Emal, Jacqueline Cale, Enming Joe Su, Mark Warnock, Shih-Hon Li, Jeanne Ann Cupp Sep 2015

Plasminogen Activator Inhibitor-1 Inhibitors And Methods Of Use Thereof To Modulate Lipid Metabolism, Daniel A. Lawrence, Cory Emal, Jacqueline Cale, Enming Joe Su, Mark Warnock, Shih-Hon Li, Jeanne Ann Cupp

Patents

The invention relates to plasminogen activator-I (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.


Department Of Surgery Update, September 2015, Wright State University Department Of Surgery Sep 2015

Department Of Surgery Update, September 2015, Wright State University Department Of Surgery

Department of Surgery Updates

A three page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, scholarly activity and more.


Towards An Automated Screening Tool For Pediatric Speech Delay, Roozbeh Sadeghian, Stephen A. Zahorian Sep 2015

Towards An Automated Screening Tool For Pediatric Speech Delay, Roozbeh Sadeghian, Stephen A. Zahorian

Faculty Works

Speech delay is a childhood language problem that sometimes is resolved on its own but sometimes may cause more serious language difficulties later. This leads therapists to screen children for detection at early ages in order to eliminate future problems. Using the Goldman-Fristoe Test of Articulation (GFTA) method, therapists listen to a child's pronunciation of certain phonemes and phoneme pairs in specified words and judge the child's stage of speech development. The goal of this paper is to develop an Automatic Speech Recognition (ASR) tool and related speech processing methods which emulate the knowledge of speech therapists. In this paper …


Six Principles To Consider When Working With Roman Catholic Clients, Thomas G. Plante Sep 2015

Six Principles To Consider When Working With Roman Catholic Clients, Thomas G. Plante

Psychology

Although the majority of Americans consider themselves to be Christian and affiliated with various Protestant denominations, a quarter of the American population identify themselves as Roman Catholics who are the largest single religious denomination in the country. Yet, surprisingly, fairly little research has been published in the professional psychology literature about working with this very large and diverse group. Psychologists have an ethical responsibility to be aware of and respectful to diversity including diversity based on religious background, affiliation, and perspectives. The purpose of this brief reflection is to offer 6 important principles to keep in mind for professional psychologists …


Perceived Barriers To Infection Prevention And Control For Nursing Home Certified Nursing Assistants: A Qualitative Study., Jasmine Travers, Carolyn T A Herzig, Monika Pogorzelska-Maziarz, Eileen Carter, Catherine C Cohen, Patricia K Semeraro, Ragnhildur I Bjarnadottir, Patricia W Stone Sep 2015

Perceived Barriers To Infection Prevention And Control For Nursing Home Certified Nursing Assistants: A Qualitative Study., Jasmine Travers, Carolyn T A Herzig, Monika Pogorzelska-Maziarz, Eileen Carter, Catherine C Cohen, Patricia K Semeraro, Ragnhildur I Bjarnadottir, Patricia W Stone

College of Nursing Faculty Papers & Presentations

Healthcare-associated infections, while preventable, result in increased morbidity and mortality in nursing home (NH) residents. Frontline personnel, such as certified nursing assistants (CNAs), are crucial to successful implementation of infection prevention and control (IPC) practices. The purpose of this study was to explore barriers to implementing and maintaining IPC practices for NH CNAs as well as to describe strategies used to overcome these barriers. We conducted a multi-site qualitative study of NH personnel important to infection control. Audio-recorded interviews were transcribed verbatim and transcripts were analyzed using conventional content analysis. Five key themes emerged as perceived barriers to effective IPC …


Family Planning Knowledge, Attitudes, And Practices Among Married Men And Women In Rural Areas Of Pakistan: Findings From A Qualitative Need Assessment Study, Ghulam Mustafa, Syed Khurram Azmat, Waqas Hameed, Safdar Ali, Muhammad Ishaque, Wajahat Hussain, Aftab Ahmed, Erik Munroe Sep 2015

Family Planning Knowledge, Attitudes, And Practices Among Married Men And Women In Rural Areas Of Pakistan: Findings From A Qualitative Need Assessment Study, Ghulam Mustafa, Syed Khurram Azmat, Waqas Hameed, Safdar Ali, Muhammad Ishaque, Wajahat Hussain, Aftab Ahmed, Erik Munroe

Community Health Sciences

This paper presents the findings of a qualitative assessment aimed at exploring knowledge, attitudes, and practices regarding family planning and factors that influence the need for and use of modern contraceptives. A descriptive exploratory study was conducted with married women and men aged between 15 and 40. Overall, 24 focus group discussions were conducted with male and female participants in three provinces of Pakistan. The findings reveal that the majority knew about some modern contraceptive methods, but the overall contraceptive use was very low. Knowledge and use of any contraceptive method were particularly low. Reasons for not using family planning …


Stroke Manifesto - What Must Be Done For Stroke Care In Pakistan, Abdul Malik, Ismail Khatri, Mohammad Wasay Sep 2015

Stroke Manifesto - What Must Be Done For Stroke Care In Pakistan, Abdul Malik, Ismail Khatri, Mohammad Wasay

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.


The Specificity And Sensitivity Of Ultrasonography In The Diagnosis Of Acute Right Lower Quadrant Pain In Women Of Child Bearing Age, Shumaila Arooj, Arfanul Haq, Zafar Amin Sep 2015

The Specificity And Sensitivity Of Ultrasonography In The Diagnosis Of Acute Right Lower Quadrant Pain In Women Of Child Bearing Age, Shumaila Arooj, Arfanul Haq, Zafar Amin

Department of Radiology

Abstract

OBJECTIVE:

To assess the sensitivity and specificity of ultrasonography in differentiating causes of acute right lower quadrant pain in women of child-bearing age by taking surgical outcome as the gold standard.

METHODS:

The descriptive analytical study was conducted at PNS Shifa Hospital, Karachi, from July to December 2008, and comprised female patients of child-bearing age who presented with acute right lower quadrant pain and underwent surgery after ultrasonography. SPSS 10 was used for statistical analysis.

RESULTS:

Of the 75 patients, 54(72%) patients were symptomatically and sonographically positive to have either acutely inflamed non-compressible appendix or focal fluid collection in …


Clinical Significance Of The Integrin Α6Β4 In Human Malignancies, Rachel L Stewart, Kathleen L O'Connor Sep 2015

Clinical Significance Of The Integrin Α6Β4 In Human Malignancies, Rachel L Stewart, Kathleen L O'Connor

Pathology and Laboratory Medicine Faculty Publications

Integrin α6β4 is a cellular adhesion molecule that binds to laminins in the extracellular matrix and nucleates the formation of hemidesmosomes. During carcinoma progression, integrin α6β4 is released from hemidesmosomes, where it can then signal to facilitate multiple aspects of tumor progression including sustaining proliferative signaling, tumor invasion and metastasis, evasion of apoptosis, and stimulation of angiogenesis. The integrin achieves these ends by cooperating with growth factor receptors including EGFR, ErbB-2, and c-Met to amplify downstream pathways such as PI3K, AKT, MAPK, and the Rho family small GTPases. Furthermore, it dramatically alters the transcriptome …


Openness To Change: Experiential And Demographic Components Of Change In Local Health Department Leaders, Emmanuel D. Jadhav, James W. Holsinger Jr., David W. Fardo Sep 2015

Openness To Change: Experiential And Demographic Components Of Change In Local Health Department Leaders, Emmanuel D. Jadhav, James W. Holsinger Jr., David W. Fardo

Preventive Medicine and Environmental Health Faculty Publications

BACKGROUND: During the 2008-2010 economic recession, Kentucky local health department (LHD) leaders utilized innovative strategies to maintain their programs. A characteristic of innovative strategy is leader openness to change. Leader demographical research in for-profit organizations has yielded valuable insight into leader openness to change. For LHD leaders, the nature of the association between leader demographic and organizational characteristics on leader openness to change is unknown. The objectives of this study are to identify variation in openness to change by leaders' demographic and organizational characteristics and to characterize the underlying relationships.

MATERIALS AND METHODS: The study utilized Spearman rank correlations test …


Game Theory And The Surgeon, Alan P. Marco Sep 2015

Game Theory And The Surgeon, Alan P. Marco

Anesthesiology Faculty Publications

How the controversial study of strategic decision-making plays out in our profession.


Intrapersonal Competencies And Service Leadership, Daniel T. L. Shek, Li Lin Sep 2015

Intrapersonal Competencies And Service Leadership, Daniel T. L. Shek, Li Lin

Pediatrics Faculty Publications

Intrapersonal competencies form the foundation of one’s development, and they are fundamental qualities of leadership competences. Four types of intelligence are highlighted in the literature of positive psychology: intelligence quotient (IQ), emotional intelligence quotient (EQ), adversity quotient (AQ) and spiritual intelligence quotient (SQ). It is argued that these competences are important in a service leader. Through this lecture, it is expected that students will understand the basic concepts and the importance of different intrapersonal competencies (IQ, EQ, AQ and SQ). We also discuss the relationship between these intrapersonal competencies and effective service leadership. Finally, ways to promote different intrapersonal competencies …


การศึกษาวัฒนธรรมองค์การพยาบาล เครือโรงพยาบาลกรุงเทพดุสิตเวชการ กลุ่มภาคตะวันออก, พิมพ์ชนก จามะรี, กัญญดา ประจุศิลป Sep 2015

การศึกษาวัฒนธรรมองค์การพยาบาล เครือโรงพยาบาลกรุงเทพดุสิตเวชการ กลุ่มภาคตะวันออก, พิมพ์ชนก จามะรี, กัญญดา ประจุศิลป

Journal of Nursing Research, Innovation, and Health

วัตถุประสงค์: เพื่อศึกษาวัฒนธรรมองค์การพยาบาล เครือโรงพยาบาลกรุงเทพดุสิตเวชการ กลุ่มภาคตะวันออก\n \nรูปแบบการวิจัย: การวิจัยเชิงพรรณนา โดยใช้เทคนิคการวิจัยเชิงอนาคต\n \nวิธีดำเนินการวิจัย: กลุ่มตัวอย่าง คือ ผู้เชี่ยวชาญ จำนวน 17 คน ประกอบด้วย ผู้เชี่ยวชาญกลุ่มผู้บริหารโรงพยาบาล และผู้เชี่ยวชาญกลุ่มผู้บริหารทางการพยาบาล เครือโรงพยาบาลกรุงเทพดุสิตเวชการ ผู้เชี่ยวชาญกลุ่มอาจารย์พยาบาล และผู้เชี่ยวชาญในองค์กรวิชาชีพ การดำเนินการวิจัยประกอบด้วย 3 ขั้นตอน คือ ขั้นตอนที่ 1 สัมภาษณ์ความคิดเห็นเกี่ยวกับวัฒนธรรมองค์การพยาบาล เครือโรงพยาบาลกรุงเทพดุสิตเวชการ กลุ่มภาคตะวันออก ขั้นตอนที่ 2 นำข้อมูลที่ได้มาวิเคราะห์เนื้อหาแล้วนำมาสร้างแบบสอบถามวัฒนธรรมองค์การพยาบาล เครือโรงพยาบาลกรุงเทพดุสิตเวชการ กลุ่มภาคตะวันออก เพื่อให้ผู้เชี่ยวชาญแสดงความเห็นเกี่ยวกับระดับความน่าจะเป็นของวัฒนธรรมองค์การพยาบาล เครือโรงพยาบาลกรุงเทพดุสิตเวชการ กลุ่มภาคตะวันออก และขั้นตอนที่ 3 นำความคิดเห็นของผู้เชี่ยวชาญทั้ง 17 คน มาคำนวณค่ามัธยฐาน ค่าพิสัยระหว่างคลอไทล์ และให้ผู้เชี่ยวชาญยืนยันความเห็นอีกครั้ง แล้วนำข้อมูลที่ได้จากการยืนยันมาคำนวณหาค่ามัธยฐานและค่าพิสัยระหว่างควอไทล์ เพื่อสรุปผลการวิจัย\n\nผลการวิจัย: วัฒนธรรมองค์การพยาบาล เครือโรงพยาบาลกรุงเทพดุสิตเวชการ กลุ่มภาคตะวันออก ประกอบด้วย 2 ด้าน จำนวน 40 ข้อรายการ ได้แก่ 1) วัฒนธรรมองค์การด้านบุคลากรพยาบาล และ 2) วัฒนธรรมองค์การด้านผู้รับบริการ\n\nสรุป: ผู้บริหารทางการพยาบาลสามารถนำผลการวิจัยไปเป็นแนวทางในการจัดทำนโยบาย กลยุทธ์และแนวทางปฏิบัติที่สอดคล้องกับบริบทวัฒนธรรมขององค์การพยาบาล\n


การแสดงออกทางด้านปัญหาพฤติกรรมของเด็กที่เรียนกวดวิชาชั้นประถมศึกษาตอนปลาย เขตกรุงเทพมหานคร, นิชนันท์ เนตรสง่า, ปริชวัน จันทร์ศิร Sep 2015

การแสดงออกทางด้านปัญหาพฤติกรรมของเด็กที่เรียนกวดวิชาชั้นประถมศึกษาตอนปลาย เขตกรุงเทพมหานคร, นิชนันท์ เนตรสง่า, ปริชวัน จันทร์ศิร

Chulalongkorn Medical Journal

เหตุผลของการทำวิจัย : การใช้เวลาเรียนที่มากเกินไปของเด็กที่อยู่ในช่วงวัยประถมศึกษาตอนปลายเป็นปัจจัยสำคัญประการหนึ่งที่ส่งผลต่อสุขภาพจิตของเด็กซึ่งมีการแสดงออกผ่านพฤติกรรม ดังนั้น จึงได้ทำการศึกษาการแสดงออกด้านปัญหาพฤติกรรมของเด็กโดยทำการศึกษาในเด็กที่เรียนกวดวิชาและไม่เรียนกวดวิชาวัตถุประสงค์ : เพื่อศึกษาการแสดงออกทางด้านปัญหาพฤติกรรมของเด็กประถมศึกษาตอนปลาย ศึกษาความแตกต่างของการแสดงออกทางด้านปัญหาพฤติกรรมของเด็กที่เรียนกวดวิชากับเด็กที่ไม่เรียนกวดวิชา รวมถึงศึกษาปัจจัยที่เกี่ยวข้องกับการแสดงออกทางด้านปัญหาพฤติกรรมของเด็กที่เรียนกวดวิชาชั้นประถมศึกษาตอนปลายรูปแบบการวิจัย : การศึกษานี้เป็นการวิจัยเชิงพรรณนาศึกษา ณ เวลาใดเวลาหนึ่งสถานที่ทำการศึกษา : โรงเรียนในสังกัดสำนักงานคณะกรรมการการศึกษาขั้นพื้นฐาน (สพฐ.)เขตกรุงเทพมหานครตัวอย่างและวิธีการ : ประชากรที่ศึกษาคือ เด็กที่กำลังศึกษาอยู่ในระดับชั้นประถมศึกษาตอนปลาย ในโรงเรียนในสังกัดสำนักงานคณะกรรมการศึกษาขั้นพื้นฐานเขตกรุงเทพมหานคร จำนวน 422 คน ทำการเก็บข้อมูลโดยใช้แบบสอบถามข้อมูลส่วนบุคคล แบบสอบถามพฤติกรรมการกวดวิชาและแบบประเมินการแสดงออกทางพฤติกรรม (The strengths and difficultiesquestionnaire (SDQ) ฉบับภาษาไทย) และวิเคราะห์ข้อมูลโดยใช้Pearson correlation, independent t-test, one way ANOVA และMultiple Regression Analysis ตามความเหมาะสมผลการศึกษา : จากการประเมินการแสดงออกทางพฤติกรรม (The strengthsanddifficulties questionnaire: SDQ) โดยผู้ปกครองและเด็กพบความชุกของปัญหาพฤติกรรมร้อยละ 17.5 และ 25.8 ตามลำดับ เมื่อใช้เกณฑ์การเรียนกวดวิชาพบว่าเด็กที่เรียนกวดวิชากับเด็กที่ไม่เรียนกวดวิชามีปัญหาพฤติกรรมไม่แตกต่างกัน และพบว่าความชุกของปัญหาพฤติกรรมมีค่าใกล้เคียงกับความชุกของปัญหาพฤติกรรมในเด็กทั่วไป แสดงให้เห็นว่าการเรียนกวดวิชาไม่ได้เป็นปัจจัยทีสำคัญของการเกิดปัญหาพฤติกรรมในเด็ก และปัจจัยที่มีความสัมพันธ์กับปัญหาพฤติกรรมจากการประเมินของเด็ก ได้แก่ เพศ (p <0.05) และผลการเรียน (p <0.05) จากการประเมินของผู้ปกครอง ได้แก่ สถานภาพสมรสของบิดามารดา (p <0.01) การศึกษาของบิดามารดา (p <0.01) และผลการเรียน (p<0.01)สรุป : ปัญหาพฤติกรรมของเด็กชั้นประถมศึกษาตอนปลายโดยรวมอยู่ในระดับใกล้เคียงกับปัญหาพฤติกรรมของเด็กทั่วไป และเด็กที่เรียนกวดวิชากับเด็กที่ไม่เรียนกวดวิชามีปัญหาพฤติกรรมที่ไม่แตกต่างกัน โดยมีปัจจัยที่เกี่ยวข้องคือ เพศ สถานภาพสมรสของบิดามารดาการศึกษาของบิดามารดาและผลการเรียน.


Pharmacy Newsletter : September 2015, Pharmacy Department Sep 2015

Pharmacy Newsletter : September 2015, Pharmacy Department

Department of Pharmacy Archives

Content

  • Advancement in Pharmacotherapy
  • Auxiliary Labels
  • How to Take Oral Diabetic Medications with Food, Nutrient/Herb and other Medications?
  • Proud to Report


Today - September 2015, Loma Linda University Health Sep 2015

Today - September 2015, Loma Linda University Health

TODAY

Inside this issue:

-- Anonymous donor honors three long-time Loma Linda physicians
-- LLUMC - Murrieta accredited as chest pain center
-- SAC Health System granted new status by federal government
-- Nursing dean attends executive training at Wharton School
-- Congressman tours Children's Hospital and research facilities
-- Leadership team from Naval Hospital Twentynine Palms visits Medical Center
-- LLUMC - Murrieta to hold Family Health Fair on Sept. 27
-- School of Public Health presents 'Asthma Theatre' program at Riverside County Office of Education Head Start training
-- End-of-life issues explored and discussed during screening of the PBS …


Child Eye Health In Nampula, Mozambique And Ireland, Aoife Phelan Sep 2015

Child Eye Health In Nampula, Mozambique And Ireland, Aoife Phelan

Masters

To examine child eye health, in particular, visual impairment (VI), uncorrected refractive error (URE) and strabismus in two targeted cohorts of children in Mozambique and Ireland.


A Novel Compact Microwave Radiometric Sensor To Noninvasively Track Deep Tissue Thermal Profiles, Paolo F. Maccarini, Ankur Shah, Sharmila Y. Palani, Donald V. Pearce, Madhurima Vardhan, Paul R. Stauffer, Dario B. Rodrigues, Sara Salahi, Tiago R. Oliveira, Doug Reudink, Brent W. Snow Sep 2015

A Novel Compact Microwave Radiometric Sensor To Noninvasively Track Deep Tissue Thermal Profiles, Paolo F. Maccarini, Ankur Shah, Sharmila Y. Palani, Donald V. Pearce, Madhurima Vardhan, Paul R. Stauffer, Dario B. Rodrigues, Sara Salahi, Tiago R. Oliveira, Doug Reudink, Brent W. Snow

Department of Radiation Oncology Faculty Papers

Drawing from space technology to measure star temperature, we developed a noninvasive sensor to passively track thermal profiles in tissues well below the skin (>5cm). Ultra-low noise amplifiers combined with ultralow-loss switches in the 1- 2GHz band produce a high sensitivity multiband microwave radiometer. Due to the complex multilayer anatomy of human head, multiple sensing bands are needed to reconstruct the temperature of deep brain tissue. This is achieved by using a digitally controlled filter bank. To study its accuracy, the sensor was calibrated and tested in a multilayer phantom model of the human head with differential scalp and …


Upper Airway Stimulation For Treatment Of Obstructive Sleep Apnea, Maurits Boon, Md Sep 2015

Upper Airway Stimulation For Treatment Of Obstructive Sleep Apnea, Maurits Boon, Md

Department of Otolaryngology - Head and Neck Surgery Presentations and Grand Rounds

  • What is OSA-Consequences of untreated OSA
  • CPAP Therapy
  • Why do we need alternatives to positive airway pressure (PAP) therapy
  • How do we evaluate for alternative treatments
  • Who is a candidate
  • What are the alternatives


Borrelia Burgdorferi Reva Significantly Affects Pathogenicity And Host Response In The Mouse Model Of Lyme Disease, Rebecca Byram, Robert A. Gaultney, Angela M. Floden, Christopher Hellekson, Brandee L. Stone, Amy Bowman, Brian Stevenson, Barbara J. B. Johnson, Catherine A. Brissette Sep 2015

Borrelia Burgdorferi Reva Significantly Affects Pathogenicity And Host Response In The Mouse Model Of Lyme Disease, Rebecca Byram, Robert A. Gaultney, Angela M. Floden, Christopher Hellekson, Brandee L. Stone, Amy Bowman, Brian Stevenson, Barbara J. B. Johnson, Catherine A. Brissette

Microbiology, Immunology, and Molecular Genetics Faculty Publications

The Lyme disease spirochete, Borrelia burgdorferi, expresses RevA and numerous outer surface lipoproteins during mammalian infection. As an adhesin that promotes bacterial interaction with fibronectin, RevA is poised to interact with the extracellular matrix of the host. To further define the role(s) of RevA during mammalian infection, we created a mutant that is unable to produce RevA. The mutant was still infectious to mice, although it was significantly less well able to infect cardiac tissues. Complementation of the mutant with a wild-type revA gene restored heart infectivity to wild-type levels. Additionally, revA mutants led to increased evidence of arthritis, …


Muscle Weakness During Aging: A Deficiency State Involving Declining Angiogenesis, Charles T. Ambrose Sep 2015

Muscle Weakness During Aging: A Deficiency State Involving Declining Angiogenesis, Charles T. Ambrose

Microbiology, Immunology, and Molecular Genetics Faculty Publications

This essay begins by proposing that muscle weakness of old age from sarcopenia is due in large part to reduced capillary density in the muscles, as documented in 9 reports of aged persons and animals. Capillary density (CD) is determined by local levels of various angiogenic factors, which also decline in muscles with aging, as reported in 7 studies of old persons and animals. There are also numerous reports of reduced CD in the aged brain and other studies showing reduced CD in the kidney and heart of aged animals. Thus a waning angiogenesis throughout the body may be …


Oncolog, Volume 60, Number 09, September 2015, Sarah Bronson, Bryan Tutt, K. Nair Sep 2015

Oncolog, Volume 60, Number 09, September 2015, Sarah Bronson, Bryan Tutt, K. Nair

OncoLog MD Anderson's Report to Physicians (All issues) Archives

  • Enhanced Surgical Recovery Programs Improve Perioperative Outcomes for Cancer Patients: For patients undergoing cancer surgery, potential complications and long recovery times can delay the delivery of additional life-saving therapy. To improve patients' perioperative outcomes and clear the way for timely administration of additional therapies, several surgical teams at The University of Texas MD Anderson Cancer Center gave begun using enhanced surgical recovery programs (ESRPs).
  • New Treatments for Respiratory Viruses in Immunocompromised Patients: Viral respiratory infections are a major concern for immunocompromised patients, in whom such infections are difficult to treat and can lead to pneumonia and even death. Although few …


Trim21 Regulates Nmi-Ifi35 Complex-Mediated Inhibition Of Innate Antiviral Response, Anshuman Das, Phat X. Dinh, Asit K. Pattnaik Sep 2015

Trim21 Regulates Nmi-Ifi35 Complex-Mediated Inhibition Of Innate Antiviral Response, Anshuman Das, Phat X. Dinh, Asit K. Pattnaik

School of Veterinary and Biomedical Sciences: Faculty Publications

In this study, using an immunoprecipitation coupled with mass spectrometry approach, we have identified the E3 ubiquitin ligase Trim21 as an interacting partner of IFI35 and Nmi. We found that this interaction leads to K63-linked ubiquitination on K22 residue of Nmi, but not IFI35. Using domain deletion analysis, we found that the interaction is mediated via the coiled-coil domain of Nmi and the carboxyl-terminal SPRY domain of Trim21. Furthermore, we show that depletion of Trim21 leads to significantly reduced interaction of Nmi with IFI35, which results in the abrogation of the negative regulatory function of the Nmi-IFI35 complex on innate …


Constructing A Dynamic Model Of Concussion, Erin S. Kenzie, Elle L. Parks, Wayne W. Wakeland Sep 2015

Constructing A Dynamic Model Of Concussion, Erin S. Kenzie, Elle L. Parks, Wayne W. Wakeland

Complex Systems Faculty Publications and Presentations

Aim: To construct a causal-loop diagram and corresponding system dynamics model of concussion pathology and recovery at the individual scale. These models will contribute to a greater understanding of the factors involved in concussion recovery and will inform the development of a new classification system for traumatic brain injury.


Impact Of An Antimicrobial Stewardship Intervention On Urinary Tract Infection Treatment In The Emergency Department, Kelly M. Percival, Kristine M. Valenti, Stacy E. Scmittling, Brandi D. Strader, Rebecka R. Lopez, Scott Bergman Sep 2015

Impact Of An Antimicrobial Stewardship Intervention On Urinary Tract Infection Treatment In The Emergency Department, Kelly M. Percival, Kristine M. Valenti, Stacy E. Scmittling, Brandi D. Strader, Rebecka R. Lopez, Scott Bergman

SIUE Faculty Research, Scholarship, and Creative Activity

STUDY OBJECTIVE:

The study objective is to assess changes in treatment of uncomplicated urinary tract infections (UTIs) after implementation of recommendations based on national guidelines and local resistance rates.

METHODS:

This preintervention and postintervention study included patients discharged home from the emergency department (ED) with an uncomplicated UTI at a 439-bed teaching hospital. Emergency department prescribers were educated on how local antimicrobial resistance rates impact UTI practice guidelines. Empiric treatment according to recommendations was assessed as the primary outcome. Agreement between chosen therapy and isolated pathogen susceptibility was compared before and after education. Reevaluation in the ED or hospital admission …


Albumin Administration In Acute Ischemic Stroke: Safety Analysis Of The Alias Part 2 Multicenter Trial, Michael D. Hill, Renee H. Martin, Yuko Y. Palesch, Claudias S. Moy, Diego Tamariz, Karla J. Ryckborst, Elizabeth B. Jones, David Weisman, L. Creed Pettigrew, Myron D. Ginsberg Sep 2015

Albumin Administration In Acute Ischemic Stroke: Safety Analysis Of The Alias Part 2 Multicenter Trial, Michael D. Hill, Renee H. Martin, Yuko Y. Palesch, Claudias S. Moy, Diego Tamariz, Karla J. Ryckborst, Elizabeth B. Jones, David Weisman, L. Creed Pettigrew, Myron D. Ginsberg

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Albumin treatment of ischemic stroke was associated with cardiopulmonary adverse events in previous studies and a low incidence of intracranial hemorrhage. We sought to describe the neurological and cardiopulmonary adverse events in the ALIAS Part 2 Multicenter Trial.

METHODS: Ischemic stroke patients, aged 18-83 and a baseline NIHSS ≥ 6, were randomized to treatment with ALB or saline control within 5 hours of stroke onset. Neurological adverse events included symptomatic intracranial hemorrhage, hemicraniectomy, neurological deterioration and neurological death. Cardiopulmonary adverse events included pulmonary edema/congestive heart failure, acute coronary syndromes, atrial fibrillation, pneumonia and pulmonary thromboembolism.

RESULTS: …


Occupational Therapy: Meeting The Needs Of Families Of People With Autism Spectrum Disorder, Heather Miller-Kuhaneck, Renee Watling Sep 2015

Occupational Therapy: Meeting The Needs Of Families Of People With Autism Spectrum Disorder, Heather Miller-Kuhaneck, Renee Watling

Occupational Therapy Faculty Publications

Occupational therapy has much to offer to families of people with autism spectrum disorder (ASD). However, people outside the profession may be unaware of occupational therapy’s breadth and scope. It is our responsibility and our duty to express the full range of occupational therapy services through research, clinical practice, advocacy, and consumer education. This special issue of the American Journal of Occupational Therapy, with its focus on autism, embarks on this endeavor by highlighting research and theoretical articles that address the various aspects of occupational therapy practice that can help to fully meet the needs of people with ASD and …


The Role Of Pharmacists In Lgbtq Health, Cecilia M. Plaza, Jennifer Mathews, Tari Hanneman Sep 2015

The Role Of Pharmacists In Lgbtq Health, Cecilia M. Plaza, Jennifer Mathews, Tari Hanneman

Pharmacy Faculty/Staff Publications

Pharmacists are one of the most accessible healthcare providers and often can serve as the first point of contact for patients with the healthcare system. This session explored the role of that pharmacist on the healthcare team related to LGBTQ health. The new Center for the Advancement of Pharmacy Education (CAPE) Educational Outcomes were discussed as well as current efforts within pharmacy education in LGBTQ health education. The speakers also addressed barriers to LGBTQ education and practice along with potential solutions.


Medical Marijuana And Pharmacy Practice, Karl G. Williams Sep 2015

Medical Marijuana And Pharmacy Practice, Karl G. Williams

Pharmacy Faculty/Staff Publications

By way of the Compassionate Care Act of 2014, New York has become the 23rd state to create a process that will permit patients suffering from a “serious condition” to receive medical marijuana (or “cannabis”). Among those, it is the second state to prohibit the crude delivery system of smoking (Minnesota), and the third to involve pharmacists in the dispensing process (Connecticut and Minnesota). Because virtually every practicing pharmacist in New York will be caring for patients receiving some form of cannabinoid therapy, it is important to discuss the basic outlines established by the law and regulations.