Medicine and Health Sciences Commons^™

ความเครียดของนิสิตระดับปริญญาตรี ภาควิชาสถาปัตยกรรมคณะสถาปัตยกรรมศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, ภควัต วงศ์ไทย, ชัยชนะ นิ่มนวล

Chulalongkorn Medical Journal

เหตุผลของการทำวิจัย : การเรียนการสอนในคณะสถาปัตยกรรมศาสตร์ จุฬาฯ นิสิตจะต้องใช้ความสามารถทั้งด้านศิลปะ และวิทยาศาสตร์ เพื่อให้ได้ผลงานที่สมบูรณ์แบบ และในระหว่างที่กำลัง ศึกษายังมีเรื่องของเวลา คณาจารย์และสภาพแวดล้อมต่าง ๆ ของคณะเข้ามาเกี่ยวข้องอีกด้วย ซึ่งทั้งหมดนี้อาจส่งผลต่อความเครียดของนิสิตวัตถุประสงค์ : เพื่อศึกษาระดับและปัจจัยในเรื่องการศึกษาที่เกี่ยวข้องกับความเครียดของนิสิตระดับปริญญาตรี ภาควิชาสถาปัตยกรรม คณะสถาปัตยกรรมศาสตร์ จุฬาลงกรณ์มหาวิทยาลัยรูปแบบการวิจัย : การศึกษาวิจัยเชิงพรรณนา ณ จุดเวลาใดเวลาหนึ่งสถานที่การทำการศึกษา : ภาควิชาสถาปัตยกรรม คณะสถาปัตยกรรมศาสตร์ จุฬาลงกรณ์มหาวิทยาลัยตัวอย่างและวิธีการศึกษา : เก็บรวบรวมข้อมูลจากนิสิตภาควิชาสถาปัตยกรรม คณะสถาปัตยกรรมศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย ชั้นปีที่ 1 - 5 ปีการศึกษา 2557จำนวนทั้งสิ้น 323 คน โดยใช้แบบสอบถาม ข้อมูลทั่วไปและแบบวัดความเครียด สถิติที่ใช้ได้แก่ Descriptive Statistic, Chi-Square Testและ Multiple Logistic Regression Analysisผลการศึกษา : กลุ่มตัวอย่างส่วนใหญ่ (39.7%) มีความเครียดอยู่ในระดับปานกลางมีค่าเฉลี่ยคะแนน ความเครียดรวมเท่ากับ 65.8 และค่า S.D. เท่ากับ31.1 เมื่อวิเคราะห์การถดถอยพหุคูณ ได้พบปัจจัยที่มีผลต่อความเครียดของกลุ่มตัวอย่าง ได้แก่ จำนวนงานที่ได้รับมอบหมาย ในแต่ละรายวิชาที่มาก (OR = 2.16, 95%C.I.= 1.23 - 3.80, p <0.01), จำนวนครั้งของ การตรวจแบบกับอาจารย์ประจำกลุ่มที่น้อย (OR = 0.61,95%C.I.= 0.38 - 0.98, p = 0.04) และอายุที่เพิ่มขึ้นของนิสิต(OR = 1.34, 95%C.I. = 1.11-1.60, p <0.01) ตามลำดับสรุป : นิสิตภาควิชาสถาปัตยกรรม คณะสถาปัตยกรรมศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย ส่วนมากมีความเครียดรวมในระดับปานกลาง และระดับความเครียดสัมพันธ์กับจำนวนงานที่ได้รับมอบหมายที่มากจำนวนการตรวจแบบกับอาจารย์ที่น้อย และอายุของนิสิตที่เพิ่มขึ้น.

Multiple Intussusceptions Associated With Polycythemia In An Anabolic Steroid Abuser , A Case Report And Literature Review, Y. Cavanagh, Nihar Shah Md, A. B. Thomas, A. Gupta

Gastroenterology

Intussusceptions are generally associated with mechanical lead points or localized inflammation that function as foci for intestinal telescoping. We present the case of a patient whose abuse of anabolic steroids resulted in the development of multiple simultaneous intussusceptions. Our patient had no additional identifiable risk factors for intussusception. Consistent with previous reports, corticosteroid induced polycythemia and its consequent hyperviscosity led to intravascular sludging and mesenteric ischemia with associated bowel wall thickening. The localized intestinal induration then served as mechanical foci for intussusception. Due to the illicit nature of anabolic androgenic steroid (AAS) abuse, the physiologic effects of supraphysiologic doses are …

Vulnerability, Preventability, And Responsibility: Exploring Some Normative Implications Of The Human Condition, Daniel E. Wueste

Center for the Study of Ethics in Society Papers

Presented March 17, 2015. Papers presented for the Center for the Study of Ethics in Society Western Michigan University.

Evidence For Differential Viral Oncolytic Efficacy In An In Vitro Model Of Epithelial Ovarian Cancer Metastasis, Jessica G. Tong, Yudith Ramos Valdes, John W. Barrett, John C. Bell, David Stojdl, Grant Mcfadden, J. Andrea Mccart, Gabriel E. Dimattia, Trevor G. Shepherd

Obstetrics & Gynaecology Publications

Epithelial ovarian cancer is unique among most carcinomas in that metastasis occurs by direct dissemination of malignant cells traversing throughout the intraperitoneal fluid. Accordingly, we test new therapeutic strategies using an in vitro three-dimensional spheroid suspension culture model that mimics key steps of this metastatic process. In the present study, we sought to uncover the differential oncolytic efficacy among three different viruses—Myxoma virus, double-deleted vaccinia virus, and Maraba virus—using three ovarian cancer cell lines in our metastasis model system. Herein, we demonstrate that Maraba virus effectively infects, replicates, and kills epithelial ovarian cancer (EOC) cells in proliferating adherent cells and …

Prevalence And Influences Of Preschoolers’ Sedentary Behaviors In Early Learning Centers: A Cross-Sectional Study, Patricia Tucker, Leigh M. Vanderloo, Shauna M. Burke, Jennifer D. Irwin, Andrew M. Johnson

Occupational Therapy Publications

Background

Recent research has highlighted the need for increased evidence regarding the sedentary activity levels of preschoolers. Given the large proportion of time this population spends in various early learning facilities, the exploration of sedentary behaviors within this particular environment should be a priority. The purpose of the study was two-fold: (1) to compare sedentary time of preschoolers in three different early learning environments (i.e., full-day kindergarten [FDK], center-, and home-based childcare); and (2) to assess which characteristics (i.e., staff behaviors, sedentary environment, fixed play environment, portable play environment, sedentary opportunities) of these early learning environments influence preschoolers’ sedentary time. …

Building Trust: A Critical Component Of Global Health., Obidimma C Ezezika

Health Studies Publications

Trust is a concept that we often take for granted. But as much as it serves as glue for human relationships, trust lies, albeit subtly or sometimes hidden, at the crux of all global health interventions and is critical to their success or failure. The recent Ebola pandemic in West Africa shows how distrust among the community, public health officials and government institutions can lead to a massive failure in the delivery of health care and response to a disease outbreak. Media articles and commentaries attributed the slow response to the Ebola crisis to a lack of trust on many …

Finding The Engram., Sheena A Josselyn, Stefan Köhler, Paul W Frankland

Brain and Mind Institute Researchers' Publications

Many attempts have been made to localize the physical trace of a memory, or engram, in the brain. However, until recently, engrams have remained largely elusive. In this Review, we develop four defining criteria that enable us to critically assess the recent progress that has been made towards finding the engram. Recent 'capture' studies use novel approaches to tag populations of neurons that are active during memory encoding, thereby allowing these engram-associated neurons to be manipulated at later times. We propose that findings from these capture studies represent considerable progress in allowing us to observe, erase and express the engram.

Should Suicide Behaviour Be An Outcome Parameter For Mental Disorder, Amresh Srivastava

Data and Test Instruments

Suicide and mental illness are closely related to each other. A high number of people who commit suicide suffer from a mental illness, and a high number of mentally ill patients exhibit suicide behavior. Suicide behavior is a significant aspect of mental illness. It is consistently observed throughout the course of illness, seen in the prodromal stage, during acute phase of remission, in residual phase and whenever illness relapses. A number of times, mental disorder improves but suicide behavior persists. 10-15% patients attempt suicide in the initial phase of an illness. More than half of the patients get hospitalized due …

Rebuilding Postgraduate Medical Education Programmes In Afghanistan, Vivian Mcalister

Data and Test Instruments

Conflict over the last three decades has resulted in profound disruption of the medical system in Afghanistan. The NATO Training Mission–Afghanistan (NTM-A) installed a graduate medical education (GME) advisory team with the mandate to help the Afghan faculty reconstruct modern teaching programs for core specialties including programs for assistant personnel.Le conflit des trois deniers décades a entraîné de très importantes perturbations du système médical en Afghanistan. La Mission de Formation de l'OTAN –Afghanistan (NTM-A) a mis en place une équipe de conseillers en formation médicale (GME) avec la mission d'aider la faculté Afghane a reconstituer des programmes modernes d'enseignement des …

Mobility And Cognition In Seniors. Report From The 2008 Institute Of Aging (Cihr) Mobility And Cognition Workshop, Manuel Montero-Odasso, Louis Bherer, Stephanie Studenski, Karen Gopaul, Afua Oteng-Amoako, Sarah Woolmore-Goodwin, Paul Stoole, Jennie Wells, Timothy Doherty, Aleksandra A. Zecevic, David Galinsky, R. Jane Rylett, Jeffrey Jutai, Susan W. Muir-Hunter, Mark Speechley, Richard Camicioli

Physical Therapy Publications

Background

The annual Scientific Meeting of the Canadian Association on Gerontology was held on October 24 and 25, 2008 in London, Ontario. Prior to the annual meeting, mobility and cognition experts met on October 23, 2008 to engage in a pre-conference workshop.

Methods

Discussions during the workshop addressed novel areas of research and knowledge and research gaps pertaining to the interaction between mobility and cognition in seniors.

Results

Workshop presenters moved from the neuromuscular, biomechanics, and neurology of gait impairments, and falls through the role of cognition and mood on mobility regulation to the whole person in the environment. Research …

The Conserved G-Protein Coupled Receptor Fshr-1 Regulates Protective Host Responses To Infection And Oxidative Stress, Elizabeth V. Miller, Leah N. Grandi, Jennifer A. Giannini, Joseph D. Robinson, Jennifer R. Powell

Biology Faculty Publications

The innate immune system’s ability to sense an infection is critical so that it can rapidly respond if pathogenic microorganisms threaten the host, but otherwise maintain a quiescent baseline state to avoid causing damage to the host or to commensal microorganisms. One important mechanism for discriminating between pathogenic and non-pathogenic bacteria is the recognition of cellular damage caused by a pathogen during the course of infection. InCaenorhabditis elegans, the conserved G-protein coupled receptor FSHR-1 is an important constituent of the innate immune response. FSHR-1 activates the expression of antimicrobial infection response genes in infected worms and delays accumulation …

Promoting Active Living In Rural Communities, Anush Yousefian Hansen Ms, Ma, David Hartley Phd, Mha

Population Health

This brief summarizes current research on elements of the rural built environment that may be related to obesity or physical activity. Much of this research is qualitative in nature, including evidence and conclusions drawn from rural focus groups, PhotoVoice studies, policy statements, observations from the field, and lessons learned from rural active living interventions.

Student Fellows 2015-2016, Place

PLACE Historical Documents

This document provides biographies of PLACE student fellows at Linfield College for 2015-2016.

Discordant Identification Of Pediatric Severe Sepsis By Research And Clinical Definitions In The Sprout International Point Prevalence Study, S. L. Weiss, J. C. Fitzgerald, F. A. Maffei, J. M. Kane, A. Rodriguez-Nunez, Michael C. Spaeder, +260 Additional Authors

Pediatrics Faculty Publications

Introduction

Consensus criteria for pediatric severe sepsis have standardized enrollment for research studies. However, the extent to which critically ill children identified by consensus criteria reflect physician diagnosis of severe sepsis, which underlies external validity for pediatric sepsis research, is not known. We sought to determine the agreement between physician diagnosis and consensus criteria to identify pediatric patients with severe sepsis across a network of international pediatric intensive care units (PICUs).

Methods

We conducted a point prevalence study involving 128 PICUs in 26 countries across 6 continents. Over the course of 5 study days, 6925 PICU patients <18 years of age were screened, and 706 with severe sepsis defined either by physician diagnosis or on the basis of 2005 International Pediatric Sepsis Consensus Conference consensus criteria were enrolled. The primary endpoint was agreement of pediatric severe sepsis between physician diagnosis and consensus criteria as measured using Cohen’s κ. Secondary endpoints included characteristics and clinical outcomes for patients identified using physician diagnosis versus consensus criteria.

Results

Of the …

Csf And Blood Levels Of Gfap In Alexander Disease(1,2,3)., Paige L Jany, Guillermo E Agosta, William S Benko, Jens C Eickhoff, Stephanie R Keller, Adeline Vanderver, +13 Additional Authors

Neurology Faculty Publications

Alexander disease is a rare, progressive, and generally fatal neurological disorder that results from dominant mutations affecting the coding region of GFAP, the gene encoding glial fibrillary acidic protein, the major intermediate filament protein of astrocytes in the CNS. A key step in pathogenesis appears to be the accumulation of GFAP within astrocytes to excessive levels. Studies using mouse models indicate that the severity of the phenotype correlates with the level of expression, and suppression of GFAP expression and/or accumulation is one strategy that is being pursued as a potential treatment. With the goal of identifying biomarkers that indirectly reflect …

Himmelfarb Library Liaison Letter - September 2015, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Impact Of Dietary Components On Nk And Treg Cell Function For Cancer Prevention, Young S. Kim, Thomas J. Sayers, Nancy H. Colburn, John A. Milner, Howard A. Young

United States Public Health Resources

An important characteristic of cancer is that the disease can overcome the surveillance of the immune system. A possible explanation for this resistance arises from the ability of tumor cells to block the tumoricidal activity of host immune cells such as natural killer (NK) cells by inducing the localized accumulation of regulatory T (Treg) cells. Evidence exists that components in commonly consumed foods including vitamins A, D, and E, water-soluble constituents of mushrooms, polyphenolics in fruits and vegetables, and n-3 fatty acids in fish oil can modulate NK cell activities, Treg cell properties, and the interactions between those two cell …

Longitudinal Analysis Of Electronic Health Records On Staffing Mix In Community Health Centers, Bianca K. Frogner, Xiaoli Wu, Jeongyoung Park, Patricia Pittman

Health Workforce Research Center Publications

Community health centers (CHCs) have long faced clinical staffing challenges especially in rural areas of the US due to providers perceiving a lack of socioeconomic opportunities. A recent study found that CHCs are adaptable and manage to maintain productivity levels across different staffing configurations by leveraging the clinical staff available. What is unknown is how two major changes in the health care landscape—adoption of an electronic health record (EHR) system and recognition of being a patient-centered medical home (PCMH)—have impacted staffing in CHCs, which may in turn have productivity implications.

An Overview Of Acute Myeloid Leukemia, Ryan Durkee

Honors Projects

Acute Myeloid Leukemia is a rare disease with an estimated 20,830 new cases in the U.S. in 2015.4 Although it is a rare disease it is crucial to understand the history, pathophysiology, and epidemiology of AML. Comprehending the steps behind treating AML is another crucial aspect in appreciating the care that must be put into AML and the patients that suffer from it. A comprehensive look into these two aspects of AML will give a better understanding for what causes AML, how it is treated, and what these patients experience. Through this comprehensive study the future of this field will …

Development Of A Technology-Based Behavioral Vaccine To Prevent Adolescent Depression: A Health System Integration Model, Benjamin W. Van Voorhees, Tracy Gladstone, Stephanie Cordel, Monika Marko-Holguin, William Beardslee, Sachiko Kuwabara, Mark Allan Kaplan, Joshua Fogel, Anne Diehl, Chris Hansen, Carl Bell

Publications and Research

Efforts to prevent depression have become a key health system priority. Currently, there is a high prevalence of depression among adolescents, and treatment has become costly due to the recurrence patterns of the illness, impairment among patients, and the complex factors needed for a treatment to be effective. Primary care may be the optimal location to identify those at risk by offering an Internet-based preventive intervention to reduce costs and improve outcomes. Few practical interventions have been developed. The models for Internet intervention development that have been put forward focus primarily on the Internet component rather than how the program …

Erbb3-Erbb2 Complexes As A Therapeutic Target In A Subset Of Wild-Type Braf/Nras Cutaneous Melanomas., Claudia Capparelli, Sheera Rosenbaum, Lisa D. Berman-Booty, Amel Salhi, Nadège Gaborit, Tingting Zhan, Inna Chervoneva, Jason Roszik, Scott E. Woodman, Michael A. Davies, Yulius Y. Setiady, Iman Osman, Yosef Yarden, Andrew E. Aplin

Department of Cancer Biology Faculty Papers

The treatment options remain limited for patients with melanoma who are wild-type for both BRAF and NRAS (WT/WT). We demonstrate that a subgroup of WT/WT melanomas display high basal phosphorylation of ErbB3 that is associated with autocrine production of the ErbB3 ligand neuregulin-1 (NRG1). In WT/WT melanoma cells displaying high levels of phospho-ErbB3, knockdown of NRG1 reduced cell viability and was associated with decreased phosphorylation of ErbB3, its coreceptor ErbB2, and its downstream target, AKT. Similar effects were observed by targeting ErbB3 with either siRNAs or the neutralizing ErbB3 monoclonal antibodies huHER3-8 and NG33. In addition, pertuzumab-mediated inhibition of ErbB2 …

Rac1 P29s Regulates Pd-L1 Expression In Melanoma., Ha Linh Vu, Sheera Rosenbaum, Timothy J. Purwin, Michael A. Davies, Andrew E. Aplin

Department of Cancer Biology Faculty Papers

Whole exome sequencing of cutaneous melanoma has led to the detection of P29 mutations in RAC1 in 5-9% of samples, but the role of RAC1 P29 mutations in melanoma biology remains unclear. Using reverse phase protein array analysis to examine the changes in protein/phospho-protein expression, we identified cyclin B1, PD-L1, Ets-1, and Syk as being selectively upregulated with RAC1 P29S expression and downregulated with RAC1 P29S depletion. Using the melanoma patient samples in TCGA, we found PD-L1 expression to be significantly increased in RAC1 P29S patients compared to RAC1 WT as well as other RAC1 mutants. The finding that PD-L1 …

Expression Of The Il-11 Gene In Metastatic Cells Is Supported By Runx2-Smad And Runx2-Cjun Complexes Induced By Tgfβ1., Xuhui Zhang, Hai Wu, Jason R. Dobson, Gillian Browne, Deli Hong, Jacqueline Akech, Lucia R. Languino, Gary S. Stein, Jane B. Lian

Department of Cancer Biology Faculty Papers

In tumor cells, two factors are abnormally increased that contribute to metastatic bone disease: Runx2, a transcription factor that promotes expression of metastasis related and osteolytic genes; and IL-11, a secreted osteolytic cytokine. Here, we addressed a compelling question: Does Runx2 regulate IL-11 gene expression? We find a positive correlation between Runx2, IL-11 and TGFβ1, a driver of the vicious cycle of metastatic bone disease, in prostate cancer (PC) cell lines representing early (LNCaP) and late (PC3) stage disease. Further, like Runx2 knockdown, IL-11 knockdown significantly reduced expression of several osteolytic factors. Modulation of Runx2 expression results in corresponding changes …

Reduced Toxicity Conditioning And Allogeneic Hematopoietic Progenitor Cell Transplantation For Recessive Dystrophic Epidermolysis Bullosa, Mark B. Geyer, Kavita Radhakrishnan, Roger Giller, Noriko Umegaki, Sivan Harel, Maija Kiuru, Kimberly D. Morel, Nicole Leboeuf, Jessica Kandel, Anna Bruckner, Sandra Fabricatore, Mei Chen, David Woodley, John Mcgrath, Leeann Baxter-Lowe, Jouni Uitto, Angela M. Christiano, Mitchell S. Cairo

NYMC Faculty Publications

Recessive dystrophic epidermolysis bullosa is a severe, incurable, inherited blistering disease caused by COL7A1 mutations. Emerging evidence suggests hematopoietic progenitor cells (HPCs) can be reprogrammed into skin; HPC-derived cells can restore COL7 expression in COL7-deficient mice. We report two children with recessive dystrophic epidermolysis bullosa treated with reduced-toxicity conditioning and HLA-matched HPC transplantation.

Differences In Risk-Adjusted Outcome Of Road Traffic Injuries In Urban Tertiary Care Centers Of Pakistan, Amber Mehmood, Junaid Abdul Razzak, Mohammed Umer Mir, Rashid Jooma

Department of Emergency Medicine

Objective: To assess the differences in road injury survival in three tertiary care hospitals in an urban setting.
Methods: The study was conducted in and comprised all road traffic injury victims presenting to the three state-run tertiary care centres in Karachi from September 2006 to October 2009. Patients' age, gender, mode, and delay in arrival, severity of injury were noted. Data was stratified by hospital of presentation. A logistic regression model was developed and probability of survival was assessed after adjusting for various risk factors, including patient characteristics and injury severity.
Results: There were 93,657victims in the study, but complete …

Eating Disorder Risk, Exercise Dependence, And Body Weight Dissatisfaction Among Female Nutrition And Exercise Science University Majors, Natalie Harris, David Gee, Debra D'Acquisto, Dana Ogan, Kelly Pritchett

All Faculty Scholarship for the College of the Sciences

Background and Aims: Past research has examined eating disorder risk among college students majoring in Nutrition and has suggested an increased risk, while other studies contradict these results. Exercise Science majors, however, have yet to be fully examined regarding their risk for eating disorders and exercise dependence. Based on pressures to fit the image associated with careers related to these two disciplines, research is warranted to examine the potential risk for both eating disorder and exercise dependence. The purpose of this study is to compare eating disorder risk, exercise dependence, and body weight dissatisfaction (BWD) between Nutrition and Exercise Science …

Challenging The Efficacy Of Different Dental Bleaching Protocols, A. Koniaris, Vasileios Margaritis

Walden Faculty and Staff Publications

No abstract provided.

Human Ips Cell-Derived Astrocyte Transplants Preserve Respiratory Function After Spinal Cord Injury., Ke Li, Elham Javed, Daniel Scura, Tamara J. Hala, Suneil Seetharam, Aditi Falnikar, Jean-Philippe Richard, Ashley Chorath, Nicholas J. Maragakis, Megan C. Wright, Angelo C. Lepore

Department of Neuroscience Faculty Papers

Transplantation-based replacement of lost and/or dysfunctional astrocytes is a promising therapy for spinal cord injury (SCI) that has not been extensively explored, despite the integral roles played by astrocytes in the central nervous system (CNS). Induced pluripotent stem (iPS) cells are a clinically-relevant source of pluripotent cells that both avoid ethical issues of embryonic stem cells and allow for homogeneous derivation of mature cell types in large quantities, potentially in an autologous fashion. Despite their promise, the iPS cell field is in its infancy with respect to evaluating in vivo graft integration and therapeutic efficacy in SCI models. Astrocytes express …

Nurturing University Students To Be Social Entrepreneurs: Relevance Of Service Leadership Education, Daniel T. L. Shek, Li Lin

Pediatrics Faculty Publications

When the concept of social entrepreneurship becomes more popular, many universities explicitly claim that they wish to nurture social entrepreneurs. In this paper, the concept of social entrepreneurship and the successful attributes of social entrepreneurs are outlined. With reference to the question of how university students can be nurtured to be social entrepreneurs, it is suggested that the service leadership model proposed by the Hong Kong Institute of Service Leadership and Management is a good framework to be considered. In the framework, it is asserted that there are three attributes of a successful service leader – leadership competence, moral character, …

Method And System For Diagnosis Of Lawsonia Intracellularis, Harold F. Stills Jr., David W. Horohov, Allen E. Page

Microbiology, Immunology and Molecular Genetics Faculty Patents

A method, system, and kit are provided for diagnosing L. intracellularis infection or exposure in a subject. The method includes purifying whole L. intracellularis from host cells and host debris produced in or on a suitable medium and adhering the purified whole L. intracellularis on a suitable material to form an antigen substrate for determining whether a subject produces L. intracellularis-specific antibodies against the antigen to thereby indicate L. intracellularis exposure or infection in the subject. The kit includes purified whole L. intracellularis produced from host cells and host debris adhered to a suitable material to form an antigen …