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Articles 11851 - 11880 of 11981
Full-Text Articles in Medicine and Health Sciences
An Athletic Approach To Studying Perception-Action Integration: Does Sport-Specific Training, And The Impact Of Injury, Influence How Individuals Visually Guide Navigation?, Carmen Baker, Jennifer Campos Ph.D, Michael E. Cinelli Ph.D.
An Athletic Approach To Studying Perception-Action Integration: Does Sport-Specific Training, And The Impact Of Injury, Influence How Individuals Visually Guide Navigation?, Carmen Baker, Jennifer Campos Ph.D, Michael E. Cinelli Ph.D.
Theses and Dissertations (Comprehensive)
The objective of this thesis was to investigate perception-action integration capabilities of individuals during a choice navigation task. This task assessed navigation strategies in open space while individuals avoided colliding with two vertical obstacles that created a body-scaled, horizontal gap, at three varying obstacle distances from the starting location (3m, 5m, 7m). The two studies completed in this thesis employed the same paradigm to assess the hypothesized group differences. Gaze behaviours and kinematics of navigation strategies were compared between: 1) athletes specifically trained in navigating in open space versus non-athletes; and 2) athletes with post-concussion syndrome (PCS) versus non-concussed, specifically …
Transient Trunk Flexion: The Potential To Alleviate Low Back Pain During Prolonged Standing, Danielle M. Stewart
Transient Trunk Flexion: The Potential To Alleviate Low Back Pain During Prolonged Standing, Danielle M. Stewart
Theses and Dissertations (Comprehensive)
The current study examined potential benefits of intermittent, short-term periods of full trunk flexion on the development of low back pain (LBP) over two hours of standing. Sixteen participants completed a 2-hour standing protocol, on two separate days. On one day, participants stood statically for 2 hours; on the other day participants bent forward to full spine flexion for 5 seconds every 15-minutes. During both protocols, participants reported LBP using a 100mm visual analogue scale every 15-minutes. During the flexion trials, erector spinae muscle activation was monitored. Ultimately, intermittent trunk flexion reduced LBP by 36% (10mm) at the end of …
The Effect Of Training Older Adults In Tai Chi And Compensatory Stepping On Balance Control, Hannah L. Moore Miss
The Effect Of Training Older Adults In Tai Chi And Compensatory Stepping On Balance Control, Hannah L. Moore Miss
Theses and Dissertations (Comprehensive)
Abstract
Introduction: In Canadian society, there is a growing prevalence of older adults and one of the main problems facing this generation today is the risk of falling. Tai Chi (TC) is a martial art that has demonstrated improvements in balance control. It uses a series of fluid movements that engage head, neck and trunk rotation while simultaneously reducing base of support. In addition, it has been demonstrated that training older adults by administering unpredictable perturbations to challenge balance better equips them to react successfully in response to balance perturbations. This study aims to determine the potential balance specific benefits …
The Therapeutic Contributions Of Somatosensory Feedback During Exercise For Those With Parkinson's Disease, Matthew T. Lasswell
The Therapeutic Contributions Of Somatosensory Feedback During Exercise For Those With Parkinson's Disease, Matthew T. Lasswell
Theses and Dissertations (Comprehensive)
Previous research has proposed that the somatosensory feedback generated during exercise is a key component in regards to the mechanism underlying the therapeutic effects of exercise on the motor symptoms of Parkinson’s disease (PD). This thesis aimed to further examine the contributions of different forms of somatosensory feedback during exercise in PD in order to understand the mechanism for symptom improvements that certain exercise studies report.
This randomized, controlled exercise study consisted of three treadmill groups, with the RATE and MAGNITUDE groups serving as the experimental conditions, while the CONTROL condition was an active comparator treadmill walking group. The RATE …
Endovascular Repair Of Ruptured Pseudoaneurysm Of Left Internal Mammary Graft Following Redo Aortic Valve Replacement And Coronary Artery Bypass Grafting., Sanjeev U. Nair Md, Nainesh C. Patel Md, David A. Cox Md
Endovascular Repair Of Ruptured Pseudoaneurysm Of Left Internal Mammary Graft Following Redo Aortic Valve Replacement And Coronary Artery Bypass Grafting., Sanjeev U. Nair Md, Nainesh C. Patel Md, David A. Cox Md
Department of Medicine
No abstract provided.
Evaluation Of Common Risk Factors For Breast Carcinoma In Females: A Hospital Based Study In Karachi, Pakistan, Saira Naz Sufian, Imrana Masroor, Waseem Mirza, Sehrish Butt, Shaista Afzal, Zafar Sajjad
Evaluation Of Common Risk Factors For Breast Carcinoma In Females: A Hospital Based Study In Karachi, Pakistan, Saira Naz Sufian, Imrana Masroor, Waseem Mirza, Sehrish Butt, Shaista Afzal, Zafar Sajjad
Department of Radiology
Background: Breast malignancies are one of the leading causes of deaths in females worldwide. There are a number of risk factors associated with breast cancer but in Karachi Pakistan there are insufficient data available.
Materials and methods: A case control study was conducted on females in age group between 30-80 years. This study was accomplished by retrospective data collection in Aga Khan University Hospital Karachi, Pakistan. A total of 108 females with primary malignancy of breast were included along with 108 matched controls. Relationship of various factors with disease was studied using logistic regression to calculate odds ratios with 95 …
Fibrodysplasia Ossificans Progressiva Misdiagnosed As Cervical Exostosis, Muhammad Awais, Abdul Rehman, Noor Ul-Ain Baloch
Fibrodysplasia Ossificans Progressiva Misdiagnosed As Cervical Exostosis, Muhammad Awais, Abdul Rehman, Noor Ul-Ain Baloch
Department of Radiology
No abstract provided.
Pseudo-Thyroid Lobe: A Diagnostic Conundrum Caused By Ossified Anterior Longitudinal Ligament On Bone Scan, Maseeh Uz Zaman, Nosheen Fatima, Zafar Sajjad, Unaiza Zaman, Areeba Zaman, Rabia Tahseen
Pseudo-Thyroid Lobe: A Diagnostic Conundrum Caused By Ossified Anterior Longitudinal Ligament On Bone Scan, Maseeh Uz Zaman, Nosheen Fatima, Zafar Sajjad, Unaiza Zaman, Areeba Zaman, Rabia Tahseen
Department of Radiology
Radionuclide bone imaging is one of the most commonly performed nuclear medicine procedure around the world and characterized by its high sensitivity and relatively low specificity. False positive findings on a bone scan are very common; however, dense uptake over unilateral ossified anterior longitudinal ligament appearing as single thyroid lobe on a bone scan has not been described in the literature.
Bmx: A Tool For Computing Bacterial Phyletic Composition From Orthologous Maps, Benard W. Kulohoma
Bmx: A Tool For Computing Bacterial Phyletic Composition From Orthologous Maps, Benard W. Kulohoma
All Peer-Reviewed Publications
Background: New sequencing technologies have made it possible to explore genetic diversity at higher resolution in microbial populations. However, our understanding evolutionary relationships, and comparison of closely and distantly related bacterial genomes from these massive datasets remains a formidable challenge. Numerous clustering algorithms that group genomic data based on homology have been developed, but new tools are still required to analyse the resultant orthologous maps to understand functional genetic similarities and their phyletic patterns (patterns of presence of absence of genes). Findings: Bacterial Makeup eXplorer (BMX) implements an algorithm that swiftly and efficiently facilitates the determination of the number of …
Gender Differences In Low Back Pain And Self-Reported Muscle Strengthening Activity Among U.S. Adults, Albatool H. Alnojeidi
Gender Differences In Low Back Pain And Self-Reported Muscle Strengthening Activity Among U.S. Adults, Albatool H. Alnojeidi
UNF Graduate Theses and Dissertations
Objectives: We sought to examine the gender differences between low back pain (LBP) and muscle strengthening activity (MSA) in U.S. adults (≥20 years of age).
Background: Low back pain is a well-known medical condition that has been shown to impact quality of life and professional productivity. It also adds to the financial burden of our healthcare system by augmenting medical treatment costs. Muscle strengthening activity is a recognized method to prevent and treat LBP. Studies analyzing the relationship between MSA and LBP by gender have produced mixed results.
Methods: The sample (n=12,721) included participants in the 1999-2004 National …
A New Obesity Model Reveals The Hypophagic Properties Of Pacap Involve The Regulation Of Homeostatic Feeding In The Ventromedial Hypothalamic Nucleus And Hedonic Feeding In The Nucleus Accumbens, Matthew M. Hurley, Brian Maunze, Jon M. Resch, Mogen M. Frenkel, M. J. Reilley, Megan E. Block, David A. Baker, Sujean Choi
A New Obesity Model Reveals The Hypophagic Properties Of Pacap Involve The Regulation Of Homeostatic Feeding In The Ventromedial Hypothalamic Nucleus And Hedonic Feeding In The Nucleus Accumbens, Matthew M. Hurley, Brian Maunze, Jon M. Resch, Mogen M. Frenkel, M. J. Reilley, Megan E. Block, David A. Baker, Sujean Choi
Biomedical Sciences Faculty Research and Publications
Binge eating in humans is a complex disorder that often involves discrete, compulsive feeding sessions of highly palatable foods even in the absence of a deprivation state or hunger. Binging can be effectively modeled in rodents by providing subjects with limited access to a palatable food source (Western Diet; WD) as an adjunct to ad lib access to normal chow (Standard Chow; SC). Although this design recapitulates several fundamental characteristics observed in binge eating disorder, the binge eating observed in this paradigm is likely a product of both hedonic and homeostatic drives with the need to balance energy stores still …
Breast-Feeding And Postpartum Maternal Weight Trajectories, Laura Mullaney, Amy O'Higgins, Shona Cawley, Rachel Kennedy, Daniel Mccartney, Michael J. Turner
Breast-Feeding And Postpartum Maternal Weight Trajectories, Laura Mullaney, Amy O'Higgins, Shona Cawley, Rachel Kennedy, Daniel Mccartney, Michael J. Turner
Articles
We examined whether breast-feeding, and in particular exclusive breast-feeding, was associated with maternal weight and body composition changes at 4 months postpartum independently of other maternal variables.
Stories Of Contaminated Waste Dump Sites In Amskapi Pikuni Blackfeet Country, Kimberly L. Paul
Stories Of Contaminated Waste Dump Sites In Amskapi Pikuni Blackfeet Country, Kimberly L. Paul
Graduate Student Theses, Dissertations, & Professional Papers
Abstract:
Significant health disparities affect much of the American Indian/Alaska Native (AI/AN) and Native Hawaiian (NH) populations of America.3,6,10,11,14 Inequalities in health care and delivery of services for these populations are a contributing factor to disparate health conditions.2 Lack of equity in areas such as social services18, education, environmental contaminants5,7,8,17, historical trauma1 and acute poverty[a1] [KP2] 16, 19 strongly influence health conditions4. People residing within the remaining tribal lands of the Northern Plains experience markedly higher incidence of disease than other ethnicities within this nation10, ultimately …
A Needs Assessment: Barriers To Wildland Firefighter Fitness Training, Aria E. Mangan
A Needs Assessment: Barriers To Wildland Firefighter Fitness Training, Aria E. Mangan
Graduate Student Theses, Dissertations, & Professional Papers
Abstract:
Mangan, Aria, M.S, Spring 2015 Health and Human Performance
A Needs Assessment: Barriers to Wildland Firefighters Fitness Training
Chairperson: Dr. Annie Sondag
Introduction: Working on a wildland fire can be physically and mentally taxing. Given the physical demands of the job, fitness is a key component in keeping wildland firefighters (WLFFs) healthy and safe from injury. Unfortunately little is known about physical training (PT) programs of WLFFs.
Purpose: The purpose of this study was to examine motivators and barriers to PT in WLFFs. Personal, interpersonal, organizational and environmental factors that influence PT were identified. Strategies for overcoming barriers were …
The Personal And The Professional: Buddhist Practice And Systemic Therapists, Joanne R. Grassia
The Personal And The Professional: Buddhist Practice And Systemic Therapists, Joanne R. Grassia
Antioch University Dissertations & Theses
This dissertation consists of two articles. The first article presents a literature review of research on therapists’ personal and professional lives as practitioners of Buddhist meditation and psychotherapy in the past ten years. Nineteen articles were reviewed that met the inclusion criteria of a) between 2004 and 2014; b) exploring meditation; and c) studies related to therapist personal or professional lives. The results of the review identified four broad themes: a) presence and acceptance; b) empathy; c) countertransference; and d) self-care/compassion and gratitude. The content analysis indicated a positive association between therapist meditation practice and therapist qualities, both for personal …
Behavioral Adjustment In Children With Life Threatening Illness A Qualitative Study, E. Joseph Becher Jr.
Behavioral Adjustment In Children With Life Threatening Illness A Qualitative Study, E. Joseph Becher Jr.
Antioch University Dissertations & Theses
This study investigated factors that affect adjustment in children with life-threatening illness from the viewpoint of the parents/caregivers. The data were collected from parents/caregivers whose children have a life threatening diagnosis. Parents/caregivers were interviewed and asked to complete the Parent Request Questionnaire (PRQ) which was given to them after the in-person interview. This newly developed PRQ was utilized into prior research to predict the levels of adjustment in children. It includes age, whether the child has been informed of the diagnosis, whether the child engages in age-appropriate activities, the child's prior experience with death, the child's family's involvement in treatment, …
A Phenomenological Study: Marriage And Family Therapists' And Clinician's Perceptions Of How Secondary Traumatic Stress Affects Them And Their Families, Norja Elizabeth Cunningham
A Phenomenological Study: Marriage And Family Therapists' And Clinician's Perceptions Of How Secondary Traumatic Stress Affects Them And Their Families, Norja Elizabeth Cunningham
Antioch University Dissertations & Theses
Multiple facets of clinicians' lives are influenced by compassion fatigue including physiological well-being, the perspective of clinicians in relation to the world, and psychological and emotional reactions to trauma triggers (Figley, 1998). Work stress research considers the systemic effects of stress on workers' relationships. Research also shows that romantic relationships are negatively influenced by work stress (Sanz-Vergel, Rodriguez, Bakker & Demerouti, 2012). This phenomenological study investigated the lived experience of three clinicians and how compassion fatigue was experienced in their relationships with their partners and children. Clinicians completed the Professional Quality of Life assessment and those with a score of …
A Narrative Inquiry: Case Leaders' Perspectives On Resilience In Hospice Care, Gail Renee Ahern
A Narrative Inquiry: Case Leaders' Perspectives On Resilience In Hospice Care, Gail Renee Ahern
Antioch University Dissertations & Theses
This study is a qualitative inquiry examining the perspective of team leaders within hospice organizations on resilience. The goal of this study was to examine how hospice leaders build resilience for themselves and within the interdisciplinary teams they lead. A framework of three key theories of leadership—servant, spiritual and authentic—was used to help in understanding the similarities and differences of the interviewed leaders and their key themes and practices. The eight leaders interviewed were from a range of hospices in diverse settings and all were directly responsible for leading interdisciplinary teams. In-depth phenomenological interviewing was undertaken until the study reached …
Creating Space For An Indigenous Approach To Digital Storytelling: "Living Breath" Of Survivance Within An Anishinaabe Community In Northern Michigan, Brenda K. Manuelito
Creating Space For An Indigenous Approach To Digital Storytelling: "Living Breath" Of Survivance Within An Anishinaabe Community In Northern Michigan, Brenda K. Manuelito
Antioch University Dissertations & Theses
As Indigenous peoples, we have a responsibility to our global community to share our collective truths and experiences, but we also deserve the respect to not be objectified, essentialized, and reified. Today, we are in a period of continual Native resurgence as many of us (re)member our prayers, songs, languages, histories, teachings, everyday stories and our deepest wisdom and understanding as Indigenous peoples--we are all “living breath” and we are “all related.” For eight years, Carmella Rodriguez and I have been nDigiStorytelling across the United States and have co-created over 1,200 digital stories with over 80 tribes for Native survivance, …
Common Psychosocial And Spiritual Factors Among Individuals Who Have Healed From Chronic Lyme Disease, Frederick Green
Common Psychosocial And Spiritual Factors Among Individuals Who Have Healed From Chronic Lyme Disease, Frederick Green
Antioch University Dissertations & Theses
This dissertation examined the subjective experience of individuals who have healed from Chronic Lyme Disease (CLD). Despite significant attention paid to the controversy over CLD diagnosis and treatment, scholarly research has neglected the psychosocial and/or spiritual factors that facilitate healing from the perspective of CLD sufferers. This study addressed this research gap by using Interpretive Phenomenological Analysis (IPA) to explore the barriers and facilitators of healing among those who have healed from CLD. Six participants who had suffered from CLD and considered themselves healed from the disease were recruited and interviewed. The qualitative data was reduced to meaning units, which …
Toward Transforming Health Systems: A Practice Study Of Organizing And Practical Inquiry In Academic Medicine, Thomas A. Ellison
Toward Transforming Health Systems: A Practice Study Of Organizing And Practical Inquiry In Academic Medicine, Thomas A. Ellison
Antioch University Dissertations & Theses
Transformation of health care systems will be grounded in new professional relations and collective, cross-disciplinary actions to impact care delivery. Organizing such relations and actions involves practical inquiry rather than applying professional knowledge. This dissertation presents an exploratory, performative study of the initial organizing of the Health Systems Innovation and Research (HSIR) Program in Health Sciences at the University of Utah. The HSIR program was conceived principally to catalyze cross-disciplinary innovation and health services research and enhance care delivery changes by documenting care improvements and publishing research. This study includes a composite narrative of the organizing and practical inquiry work …
Instead Of Suspension: Alternative Strategies For Effective School Discipline, Jenni Owen, Jane Wettach, Katie Claire Hoffman
Instead Of Suspension: Alternative Strategies For Effective School Discipline, Jenni Owen, Jane Wettach, Katie Claire Hoffman
Faculty Scholarship
No abstract provided.
Evaluation Of Pediatric Manual Wheelchair Mobility Using Advanced Biomechanical Methods, Brooke A. Slavens, Alyssa J. Schnorenberg, Christine M. Aurit, Adam Graf, Joseph J. Krzak, Kathryn Reiners, Lawrence C. Vogel, Gerald F. Harris
Evaluation Of Pediatric Manual Wheelchair Mobility Using Advanced Biomechanical Methods, Brooke A. Slavens, Alyssa J. Schnorenberg, Christine M. Aurit, Adam Graf, Joseph J. Krzak, Kathryn Reiners, Lawrence C. Vogel, Gerald F. Harris
Biomedical Engineering Faculty Research and Publications
There is minimal research of upper extremity joint dynamics during pediatric wheelchair mobility despite the large number of children using manual wheelchairs. Special concern arises with the pediatric population, particularly in regard to the longer duration of wheelchair use, joint integrity, participation and community integration, and transitional care into adulthood. This study seeks to provide evaluation methods for characterizing the biomechanics of wheelchair use by children with spinal cord injury (SCI). Twelve subjects with SCI underwent motion analysis while they propelled their wheelchair at a self-selected speed and propulsion pattern. Upper extremity joint kinematics, forces, and moments were computed using …
The Impact Of Climate Change On Human Health, Mary Snow, Richard Snow
The Impact Of Climate Change On Human Health, Mary Snow, Richard Snow
Publications
Climate change is impacting human health. An obvious effect of a warmer environment is more frequent and severe heat waves. During the European heat wave of 2003, there were an estimated 35,000 more deaths than normal in the first two weeks of August. Many of the deaths resulted from cardiovascular complications among the elderly. As heat waves become more commonplace in the future, so will the number of heat strokes and the onset of other cardiovascular problems. Higher summertime temperatures also increase tropospheric ozone concentrations which in turn affects people with asthma and causes lung and heart damage. Increases in …
Missing Photos, Suffering Withdrawal, Or Finding Freedom? How Experiences Of Social Media Non-Use Influence The Likelihood Of Reversion, Eric P.S. Baumer, Shion Guha Phd, Emily Quan, David Mimno, Geri K. Gay
Missing Photos, Suffering Withdrawal, Or Finding Freedom? How Experiences Of Social Media Non-Use Influence The Likelihood Of Reversion, Eric P.S. Baumer, Shion Guha Phd, Emily Quan, David Mimno, Geri K. Gay
Health Services and Informatics Research
This article examines social media reversion, when a user intentionally ceases using a social media site but then later resumes use of the site. We analyze a convenience sample of survey data from people who volunteered to stay off Facebook for 99 days but, in some cases, returned before that time. We conduct three separate analyses to triangulate on the phenomenon of reversion: simple quantitative predictors of reversion, factor analysis of adjectives used by respondents to describe their experiences of not using Facebook, and statistical topic analysis of free-text responses. Significant factors predicting either increased or decreased likelihood of reversion …
This Digital Life: A Neighborhood-Based Study Of Adolescents' Lives Online, Jessica Pater Phd, Andrew D. Miller, Elizabeth Mynatt
This Digital Life: A Neighborhood-Based Study Of Adolescents' Lives Online, Jessica Pater Phd, Andrew D. Miller, Elizabeth Mynatt
Health Services and Informatics Research
In Proceedings of the 33rd Annual ACM Conference on Human Factors in Computing Systems.
In this paper, we present the results of a multi-year study of the social computing practices of 179 adolescents (Mage=12.4 years, SD=1.3; range: 10-14) living in a majority-minority lower-income urban neighborhood in the Southeast U.S. We investigate shifting social media practices using annual surveys and focus groups. We describe participants’ social media use and motivations and show how that use has shifted over time. We show how participants identify social pressures and influences as well as specific behaviors including computer-mediated risky behaviors and self-harm. We discuss …
Consanguinity And Pregnancy Outcomes In A Multi-Ethnic, Metropolitan European Population, Rolf Becker, Thomas Keller, Rolf-Dieter Wegner, Heidemarie Neitzel, Markus Stumm, Ute Knoll, Markus Stärk, Heiner Fangerau, Alan Bittles
Consanguinity And Pregnancy Outcomes In A Multi-Ethnic, Metropolitan European Population, Rolf Becker, Thomas Keller, Rolf-Dieter Wegner, Heidemarie Neitzel, Markus Stumm, Ute Knoll, Markus Stärk, Heiner Fangerau, Alan Bittles
Research outputs 2014 to 2021
Objective: The aim of the present study was to assess the risk of major anomalies in the offspring of consanguineous couples, including data on the prenatal situation. Methods: Over 20years (1993-2012), 35391 fetuses were examined by prenatal sonography. In 675 cases (1.9%), parents were consanguineous, with 307 couples (45.5%) related as first cousins, 368 couples (54.5%) beyond first cousins. Detailed information was retrieved on 31710 (89.6%) fetuses, (consanguineous 568: 1.8%). Results: Overall prevalence of major anomalies among fetuses with non-consanguineous parents was 2.9% (consanguineous, 10.9%; first cousins, 12.4%; beyond first cousins, 6.5%). Adjusting the overall numbers for cases having been …
Pre-Altitude Serum Ferritin Levels And Daily Oral Iron Supplement Dose Mediate Iron Parameter And Hemoglobin Mass Responses To Altitude Exposure, Daniel A. Galvao, Laura A. Garvican-Lewis,, Chris R. Abbiss, Peter Peeling, Christopher J. Gore
Pre-Altitude Serum Ferritin Levels And Daily Oral Iron Supplement Dose Mediate Iron Parameter And Hemoglobin Mass Responses To Altitude Exposure, Daniel A. Galvao, Laura A. Garvican-Lewis,, Chris R. Abbiss, Peter Peeling, Christopher J. Gore
Research outputs 2014 to 2021
Purpose : To investigate the influence of daily oral iron supplementation on changes in hemoglobin mass (Hbmass) and iron parameters after 2–4 weeks of moderate altitude exposure.Methods :Hematological data collected from 178 athletes (98 males, 80 females) exposed to moderate altitude (1,350–3,000 m) were analysed using linear regression to determine how altitude exposure combined with oral iron supplementation influenced Hbmass, total iron incorporation (TII) and blood iron parameters [ferritin and transferrin saturation (TSAT)]. Results :Altitude exposure (mean ± s: 21 ± 3 days) increased Hbmass by 1.1% [-0.4, 2.6], 3.3% [1.7, 4.8], and 4.0% …
Effects Of Estrogens On Adipokines And Glucose Homeostasis In Female Aromatase Knockout Mice, Michelle L. Van Sinderen, Gregory R. Steinberg, Sebastian B. Jørgensen, Jane Honeyman, Jenny D. Chow, Kerrie A. Herridge, Amy L. Winship, Evdokia Dimitriadis, Margaret E.E. Jones, Evan R. Simpson, Wah C. Boon
Effects Of Estrogens On Adipokines And Glucose Homeostasis In Female Aromatase Knockout Mice, Michelle L. Van Sinderen, Gregory R. Steinberg, Sebastian B. Jørgensen, Jane Honeyman, Jenny D. Chow, Kerrie A. Herridge, Amy L. Winship, Evdokia Dimitriadis, Margaret E.E. Jones, Evan R. Simpson, Wah C. Boon
Research outputs 2014 to 2021
The maintenance of glucose homeostasis within the body is crucial for constant and precise performance of energy balance and is sustained by a number of peripheral organs. Estrogens are known to play a role in the maintenance of glucose homeostasis. Aromatase knockout (ArKO) mice are estrogen-deficient and display symptoms of dysregulated glucose metabolism. We aim to investigate the effects of estrogen ablation and exogenous estrogen administration on glucose homeostasis regulation. Six month-old female wildtype, ArKO, and 17β-estradiol (E2) treated ArKO mice were subjected to whole body tolerance tests, serum examination of estrogen, glucose and insulin, ex-vivo muscle glucose uptake, and …
Circulating Melanoma Cell Subpopulations: Their Heterogeneity And Differential Responses To Treatment, Elin S. Gray, Anna L. Reid, Samantha Bowyer, Leslie Calapre, Kelvin Siew, Robert Pearce, Lester Cowell, Markus H. Frank, Michael Millward, Mel R. Ziman Dr
Circulating Melanoma Cell Subpopulations: Their Heterogeneity And Differential Responses To Treatment, Elin S. Gray, Anna L. Reid, Samantha Bowyer, Leslie Calapre, Kelvin Siew, Robert Pearce, Lester Cowell, Markus H. Frank, Michael Millward, Mel R. Ziman Dr
Research outputs 2014 to 2021
Metastatic melanoma is a highly heterogeneous tumor; thus, methods to analyze tumor-derived cells circulating in blood should address this diversity. Taking this into account, we analyzed, using multiparametric flow cytometry, the co-expression of the melanoma markers melanoma cell adhesion molecule and melanoma-associated chondroitin sulphate proteoglycan and the tumor-initiating markers ATP-binding cassette sub-family B member 5 (ABCB5), CD271, and receptor activator of NF-κβ (RANK) in individual circulating tumor cells (CTCs) from 40 late-stage (III-IV) and 16 early-stage (I-II) melanoma patients. CTCs were heterogeneous within and between patients, with limited co-expression between the five markers analyzed. Analysis of patient matched blood and …