Medicine and Health Sciences Commons^™

Tolerance Of Thymine Glycol At The Blunt Dna Double Strand Break For Nonhomologus End Joining Repair And Interference By Base Excision Repair, Sri Lakshmi Chalasani

Theses and Dissertations

Radiotherapy is the clinical application of the ionizing radiation to treat cancer. Ionizing radiation causes multiple modes of damage to the DNA damage such as SSBs, DSBs and modified bases such as thymine glycol. These lesions can exist as clusters in one or two helical turns of DNA. DNA double-strand breaks (DSBs) are extremely toxic to cells because they can lead to genomic rearrangements and even cell death. If base lesions accompany these DSBs, there will be a substantial hindrance for repair.

NHEJ is the primary DSB repair pathway in mammalian cells. HRR repairs single strand breaks (SSBs) or Double …

On-Field Signs And Symptoms Associated With Recovery Duration After Concussion In High School And College Athletes: A Critically Appraised Topic, Jaebin Shim, Deanna H. Smith, Bonnie Van Lunen

Rehabilitation Sciences Faculty Publications

Clinical Scenario: Over the past decade, sport-related concussions have received increased attention due to their frequency and severity over a wide range of athletics. Clinicians have developed return-to-play protocols to better manage concussions in young athletes; however, a standardized process projecting the length of recovery time after concussion has remained an elusive piece of the puzzle. The recovery times associated with such an injury once diagnosed can last anywhere from 1 wk to several months. Risk factors that could lead to protracted recovery times include a history of 1 or multiple concussions and a greater number, severity, and duration of …

Effects Of A Training Program To Enhance Autonomy Supportive Behaviors Among Youth Soccer Coaches, Jody L. Langdon, Robert J. Schlote, Brandonn S. Harris, Glenn P. Burdette Iii, Sara Rothberger

Health Sciences & Kinesiology: Faculty Publications

This study aimed to evaluate the prevalence and implementation of a training emphasizing the use of autonomy supportive coaching behaviors among youth soccer coaches in game-play situations as well as evaluating its effects on motivational processes among athletes. Participants included youth sport soccer coaches and their intact teams. Coaches received a series of autonomy-supportive coaching training interventions based on successful programs in general and physical education (Reeve, Jang, Carrell, Jeon & Barch, 2004; Cheon, Reeve & Moon, 2012). Athletes completed questionnaires to assess perceived autonomy support, basic need satisfaction, and motivation (Harris & Watson, 2011). Observations indicated coaches were not …

Impact Of A Community-Based Perinatal And Newborn Preventive Care Package On Perinatal And Neonatal Mortality In A Remote Mountainous District In Northern Pakistan, Zahid Memon, Gul N Khan, Sajid Bashir Soofi, Imam Y Baig, Zulfiqar Ahmed Bhutta

Centre of Excellence in Women and Child Health

Background: There is limited evidence from community-based interventions to guide the development of effective maternal, perinatal and newborn care practices and services in developing countries. We evaluated the impact of a low-cost package of community-based interventions implemented through government sector lady health workers (LHWs) and community health workers (CHWs) of a NGO namely Aga Khan Health Services on perinatal and neonatal outcomes in a sub-population of the remote mountainous district of Gilgit, Northern Pakistan.
Methods: The package was evaluated using quasi experimental design included promotion of antenatal care, adequate nutrition, skilled delivery and healthy newborn care practices. Control areas …

Validity And Usability Of A Professional Association’S Web-Based Knowledge Translation Portal: American Physical Therapy Association’S Ptnow.Org, Judith E. Deutsch, Wendy Romney, Jan Reynolds, Tara Jo Manal

All PTHMS Faculty Publications

Background: PTNow.org is an evidence-based, on-line portal created by a professional membership association to promote use of evidence in practice and to help decrease unwarranted variation in practice. The site contains synthesis documents designed to promote efficient clinical reasoning. These documents were written and peer-reviewed by teams of content experts and master clinicians. The purpose of this paper is to report on the content and construct validity as well as usability of the site. Methods: Physical therapist participants used clinical summaries (available in 3 formats--as a full summary with hyperlinks, "quick takes" with hyperlinks, and a portable two-page version) on …

The Influence Of Participating In An International Clinical Experience During Baccalaureate Nursing Education On Interprofessional Collaboration And Teamwork For New Registered Nurses, Sherylyn Watson

Nursing Faculty Publications

An increased focus on interprofessional collaboration and teamwork in the healthcare professions had placed demands on nursing education to identify evidence based instructional strategies that bolster the interprofessional competency in prelicensure nursing education. One approach in addressing the call was to explore current educational opportunities for their effectiveness in developing interprofessional collaboration and teamwork. The popular trend in nursing education was to offer international clinical experiences that provide nursing care to impoverished people of developing countries. The current literature on these experiences had primarily focused on short-term outcomes that demonstrate personal growth of the individual, exposing opportunity for research concentrating …

Sex-Specific Genetic Effects In Physical Activity: Results From A Quantitative Genetic Analysis, Vincent P. Diego, Raquel Nichele De Chaves, John Blangero, Daniel Santos, Thayse Natacha Gomes, Fernanda Karina Dos Santos, Rui Garganta, Peter T. Katzmarzyk, José Ar Maia

School of Medicine Publications

Background: The objective of this study is to present a model to estimate sex-specific genetic effects on physical activity (PA) levels and sedentary behaviour (SB) using three generation families.

Methods: The sample consisted of 100 families covering three generations from Portugal. PA and SB were assessed via the International Physical Activity Questionnaire short form (IPAQ-SF). Sex-specific effects were assessed by genotype-by-sex interaction (GSI) models and sex-specific heritabilities. GSI effects and heterogeneity were tested in the residual environmental variance. SPSS 17 and SOLAR v. 4.1 were used in all computations.

Results: The genetic component for PA and SB domains varied from …

Application And Histology-Driven Refinement Of Active Contour Models To Functional Region And Nerve Delineation: Towards A Digital Brainstem Atlas, Nimal Patel, Sharmin Sultana, Tanweer Rashid, Dean Krusienski, Michel A. Audette

Electrical & Computer Engineering Faculty Publications

This paper presents a methodology for the digital formatting of a printed atlas of the brainstem and the delineation of cranial nerves from this digital atlas. It also describes on-going work on the 3D resampling and refinement of the 2D functional regions and nerve contours. In MRI-based anatomical modeling for neurosurgery planning and simulation, the complexity of the functional anatomy entails a digital atlas approach, rather than less descriptive voxel or surface-based approaches. However, there is an insufficiency of descriptive digital atlases, in particular of the brainstem. Our approach proceeds from a series of numbered, contour-based sketches coinciding with slices …

An O'Neill Institute Briefing Paper: Ebola, The World Health Organization, And Beyond: Toward A Framework For Global Health Security, Lawrence O. Gostin, Eric A. Friedman, Daniel Hougendobler

Georgetown Law Faculty Publications and Other Works

The West African Ebola epidemic has demonstrated that the world remains ill-prepared to respond to infectious disease outbreaks. A host of institutions are now reviewing what went wrong, and new institutions are being considered, including an African Centers for Disease Control and Prevention and World Bank-initiated Pandemic Emergency Facility. The World Health Organization itself failed in one of its core functions by allowing a preventable infectious disease to spiral out of control in the world’s poorest region. The 68th World Health Assembly (WHA), held in May 2015, provided an opportunity for the Organization to reflect on what went wrong and …

Indonesia Has It Backward: It's Not E-Cigarettes That's The Problem But Smoking, Lawrence O. Gostin

Georgetown Law Faculty Publications and Other Works

Indonesia has announced it will be banning e-cigarettes. But that would do nothing to reduce smoking, which should be the main target of those interested in reducing tobacco use deaths and harms. Rather than ban e-cigarettes, it makes more sense to regulate them effectively so that they can serve as a useful anti-smoking tool. The availability of e-cigarettes to smokers can also make much more aggressive anti-smoking strategies more practically and politically viable-–perhaps even paving the way for banning cigarettes, instead.

The Normative Authority Of The World Health Organization, Lawrence O. Gostin, Devi Sridhar, Daniel Hougendobler

Georgetown Law Faculty Publications and Other Works

The World Health Organization (WHO) was born after the devastation of World War II, as a normative agency endowed with unprecedented constitutional powers. But even as it has achieved stunning successes, such as the eradication of smallpox, it has failed to live up to the exalted expectations of the postwar health and human rights movement e exemplified most recently by its inadequate response to the Ebola epidemic. Our aim is to offer innovative ideas for restoring the Organization to its leadership position by exercising its normative authority, even as it faces a crowded and often chaotic global health architecture. Before …

Creating A Foundation For The Causal Relationship Between Libraries And Learning: A Proposed Application Of Nursing And Public Health Research Methods, Marcia A. Mardis, Sylvia K. Norton, Gail K. Dickinson, Shana Pribesh, Allison Cline, Sue Kimmel, Jody Howard

Teaching & Learning Faculty Publications

Thomas Cook, a renowned causal research expert and professor of sociology, psychology, education, and social policy at Northwestern University (USA), called for school library researchers to parallel causality determination efforts in health-related fields. In this paper, we respond to Dr. Cook’s challenge with a proposed research design centered on Mixed Research Synthesis (MRS) as part of process validated by the U.S. Department of Education and National Science Foundation’s Common Guidelines for Education Research and Development. MRS studies, often used in nursing and public health research to develop causal theories, enable researchers to develop evidence summaries; identify and adjudicate rival and …

The Use Of Geographic Information Systems And Ecological Niche Modeling To Map Transmission Risk For Visceral Leishmaniasis In Bahia, Brazil, Moara De Santana Martins

LSU Doctoral Dissertations

Leishmaniasis is a public health problem in Brazil, and despite the control programs in place, Bahia remains one of the states with the highest incidence rates of cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL). This study proposed to develop and evaluate the applicability of ecological niche models (ENM) for leishmaniasis, to determine the influence of environmental and socioeconomic factors on the incidence of these diseases at three geographic scales: national, statewide and community. Water availability, garbage collection, precipitation and temperature were the most important variables in predicting areas suitable for VL and CL in the country. The extensive geography of …

Nanoparticle Measurement, Control And Characterization: Procedure Applied To Machining Processes And Mechanical Friction, Victor Songmene, Riad Khettabi, Martin Viens, Jules Kouam, Stéphane Hallé, François Morency, Jacques Masounave, Abdelhakim Djebara

Rapports de recherche scientifique

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Alors que les nanotechnologies émergentes ouvrent des voies prometteuses dans plusieurs secteurs d’activité, des études suggèrent que les nanoparticules (NP) qu’elles génèrent pourraient avoir des effets négatifs, notamment sur la santé et sur l’environnement. Celles-ci peuvent être générées lors de la fabrication, de la manutention et de l’assemblage de pièces métalliques ordinaires et de celles à base de nanomatériaux. D’autres activités quotidiennes, telles que le freinage des automobiles, peuvent aussi produire des NP. Il est donc urgent de trouver des moyens de contrôler ces risques. Cependant, les techniques et méthodes usuelles …

Correlation Of Ultrasonographic Small Intestinal Wall Layering With Histology In Normal Dogs, Alexandre Benjamin Le Roux

LSU Master's Theses

Five intestinal layers are commonly described ultrasonographically in dogs. However, current high-frequency endosonography allows the identification of 9 layers in people. The aim of this study was to describe ex vivo small intestinal layering in dogs and correlate ultrasonographic layering with histological layers. Our hypothesis was that, similar to findings in humans, discrepancies exist in thickness and visibility of intestinal layers between histology and ultrasound in dogs. Twelve adult dogs were included in the study. They were euthanized for reasons unrelated to gastrointestinal disease, but extensive medical history was unavailable. Duodenum, jejunum and ileum samples were resected immediately after euthanasia. …

Mechanisms Controlling Stem Cell Differentiation, Tran Doan Ngoc Tran

LSU Doctoral Dissertations

Mesenchymal stem cells are multipotent cells that can differentiate into many cell types. However, the molecular mechanism controlling this process remains unclear. We utilized rat dental follicle stem cells (rDFSCs) and human adipose derived stem cells (hASCs) to study the mechanisms controlling osteogenesis and adipogenesis. Elevations in the intracellular Ca2+ concentration are a phenomenon commonly observed during stem cell differentiation but cease after the process is complete. The Transient Receptor Potential Melastatin 4 (TRPM4) is an ion channel that controls Ca2+ signals in excitable and non-excitable cells. However, there are no studies on TRPM4 in stem cells. In another study, …

Investigating The Effect Of Photographic Representations On Scores Of The Stroke And Aphasia Quality Of Life Scale-39 For People With Moderate To Severe Aphasia, Samantha Studrawa

LSU Master's Theses

Background: The Stroke and Aphasia Quality of Life-39 (SAQOL-39) is a valid and reliable measure of quality of life (QOL) for stroke survivors and people with mild-to-moderate aphasia However, it could not be validated for people with severe aphasia due to their language deficits. Research has shown that combining pictures with written text can support communication effectiveness of people with aphasia. Combining language modalities in this way is a form of alternative or augmentative communication (AAC). The use of AAC has been explored as a possibility to improve communication for people with severe aphasia (Dietz, McKelvey & Beukelman, 2006). Aim: …

Treatment Efficacy Of Manual Therapy On Speech Outcomes In Children With Spastic Cerebral Palsy: A Single-Subject Experimental Design, Chantelle B. Varnado

LSU Doctoral Dissertations

ABSTRACT Objective – The present study aimed to determine if a treatment effect is present on speech outcomes in children with spastic cerebral palsy (CP) given 5 sessions of a manual therapy treatment protocol. Methods – A single-subject experimental design (ABAB) study was devised to establish the treatment efficacy of a manual therapy protocol on speech outcomes in children with spastic CP. The protocol was administered to 5 participants, 4-6 years old. It included five intercostal stretches administered in 15-minute sessions for five sessions. During the withdrawal phase, a sham treatment was administered that included an equal dosage of treatment. …

Toll-Like Receptor 4 (Tlr4) In Acute And Chronic Renal Diseases, Anand R. Nair

LSU Doctoral Dissertations

Despite advances in its treatment, the incidence of renal diseases has been consistently increasing. Hence, there is a need to understand the underlying molecular mechanisms of the progression of kidney diseases. Recent research implicates inflammation as an important mediator of renal injury. We hypothesized that inhibiting Toll-like receptor 4 (TLR4), an upstream modulator of several inflammatory pathways, would prevent the progression of renal diseases. First, we determined the mechanism by which AngiotensinII (AngII)-induced inflammation is modulated by TLR4 using an in vitro model of rat tubulo-epithelial cells. We blocked TLR4 using gene silencing strategy in NRK52E cells. In TLR4-silenced cells, …

Do People With Aphasia Interpret Road Signs Differently Than People Without Aphasia?, Caitlin Elise Brown

LSU Master's Theses

Purpose: This study increased our understanding of how aphasia may affect interpretation of road signs. Background: Despite aphasia’s theoretical effects on road sign comprehension and promising initial findings in studies that investigated driving and aphasia, the literature examining aphasia and road signs has been sparse. Research has shown that aphasia may have some effect on road sign interpretation. However, more study is needed regarding both accuracy and response time to road sign interpretation, which are equally important for safe driving. Methods: This was a prospective, between group study that used data collected from a larger study by Donovan, Savage, Varnado, …

Reliability Of Subjective Endoscopic Parameters In The Differentiation Of Essential Voice Tremor And Adductor Spasmodic Dysphonia Using High-Speed Videoendoscopy, Lindsey A. Parker

LSU Master's Theses

Certain neurogenic voice disorders present with similar or overlapping audio perceptual voice characteristics. Developing reliable and standardized perceptual measures of vocal fold vibratory characteristics for such voice disorders can enable accurate diagnosis and lead to faster, targeted treatment. In this study, subjective perceptual vocal fold vibratory characteristics and the presence and absence of supraglottic events during phonation were investigated to differentiate between Adductor Spasmodic Dysphonia (ADSD) and Essential Vocal Fold Tremor (EVT) using high-speed videoendoscopy (HSV). The specific aims of the study were to 1) assess which subjective endoscopic vocal fold vibratory measures differentiate EVT from AdSD; and 2) assess …

Conditioned Pain Modulation Predicts Exercise-Induced Hypoalgesia In Healthy Adults, Kathy J. Lemley, Sandra K. Hunter, Marie K. Hoeger Bement

Exercise Science Faculty Research and Publications

Introduction: Conditioned pain modulation (CPM) is the concept that pain inhibits pain and has potential rehabilitation implications for exercise prescription. The purpose of this study was to determine whether changes in pressure pain perception after a thermal conditioning stimulus (i.e., CPM) was attenuated with aging and whether CPM predicted pain relief after exercise (exercise-induced hypoalgesia (EIH)) in healthy young and older adults.

Methods: Twenty young (21.9 ± 3.3 yr, 10 men) and 19 older (72.0 ± 4.5 yr, 10 men) adults participated in three sessions: one familiarization and two experimental (EIH and CPM) sessions. Pressure pain perception was assessed using …

Citrate Anticoagulation: Are Blood Donors Donating Bone?, Walter Bialkowski, Roberta Bruhn, Gustaf Edgren, Paula E. Papanek

Exercise Science Faculty Research and Publications

An estimated 2.4 million volunteer apheresis blood donation procedures were performed in the United States in 2010, and increases in the proportion of transfused blood products derived from apheresis blood collections have been consistently reported. Anticoagulation is required during apheresis and is achieved with citrate. Donor exposure to citrate causes an acute physiological response to maintain serum mineral homeostasis. Some data are available on the sequelae of this acute response in the days and weeks following exposure, raising questions about bone mineral density in regular apheresis donors. New research is emerging that addresses the potential long-term health outcomes of repeated …

Domestic Violence Against Women In Bangladesh: A Review Of The Literature And The Gaps To Fill-In By Future Interventions, Anisur Rahman Khan

Khazar Journal of Humanities and Social Sciences

Although Bangladesh maintains inadequate records of the various forms of violence against women, it is clear that domestic violence against women is the most insidious problem for women in Bangladesh. For many Bangladeshi women, home is a place of pain and humiliation and violence is an integral part of everyday life. Domestic violence against women, perpetrated by their husbands, is a multi-faceted problem in Bangladesh. The efforts of the scholars to empirically investigate the problem are inadequate and a lot of issues are yet to be explored. This review is an attempt to present the findings of the major empirical …

Slavery, Agriculture, And Malaria In The Arabian Peninsula, Benjamin Reilly

Ohio University Press Open Access Books

In Slavery, Agriculture, and Malaria in the Arabian Peninsula, Benjamin Reilly illuminates a previously unstudied phenomenon: the large-scale employment of people of African ancestry as slaves in agricultural oases within the Arabian Peninsula. The key to understanding this unusual system, Reilly argues, is the prevalence of malaria within Arabian Peninsula oases and drainage basins, which rendered agricultural lands in Arabia extremely unhealthy for people without genetic or acquired resistance to malarial fevers. In this way, Arabian slave agriculture had unexpected similarities to slavery as practiced in the Caribbean and Brazil.

This book synthesizes for the first time a body of …

Investigation Of Low Back And Shoulder Demand During Cardiopulmonary Resuscitation: The Effect Of Different Compression-Ventilation Ratios, Richard Scott Dainty

Theses and Dissertations (Comprehensive)

Background: The current American Heart Association (AHA) standard cardiopulmonary resuscitation (CPR) is performed with a compression-ventilation ratio of 30:2 (standard CPR), meaning 30 compressions are applied to the chest followed by the administration of two breaths to the victim. Some evidence has shown that performing continuous chest compressions rather than standard CPR with breaks in chest compressions for administering breaths, may increase survival rates after cardiac arrest. Cont-CPR has been shown to be very fatiguing in nature, with a significant drop in chest compression force within the first two minutes of CPR. The purpose of this study was to examine …

Influence Of Planning Resources On Gait Control In Parkinson’S Disease, Frederico P. Faria

Theses and Dissertations (Comprehensive)

Movement disturbances in individuals with Parkinson’s disease (PD) have been associated with difficulties to plan complex actions. Performance of simple and complex actions overloads resources for individuals with Parkinson’s disease (PD). However, it is unclear if central resources required to plan gait adjustments while walking exacerbate gait disturbances of patients with PD. More specifically, it is unclear how gait impairments, sensory processing, and the dopaminergic system influence the load on processing resources (e.g. cognitive load) during the planning of step modifications. In order to investigate the relative influence of these factors on cognitive load and its impact on gait control, …

The Lived Experiences Of Sandwich Generation Women And Their Health Behaviours, Allison Steiner

Theses and Dissertations (Comprehensive)

Sandwich generation caregivers simultaneously provide care to their aging parents/in-laws and at least one child under 18 years living in the home (Sinha, 2013). In 2012, 2.23 million Canadians were considered sandwiched caregivers. This group is expected to grow as individuals are delaying marriage, resulting in delayed childrearing (Robinson, Barbee, Martin, Singer, Yegidis, 2003). Further, the government has been advocating for caregiving to move from formal to informal caregiving. Although this would help the government immensely, this creates challenges for middle-aged adults occupying multiple roles. The purpose of this study was to explore the lived experiences of sandwich generation women …

Ems Use By The Young Adult Population In The Region Of Waterloo, Karen J. Totzke

Theses and Dissertations (Comprehensive)

Anecdotal evidence suggests that university students are accessing local Emergency Medical Services (EMS) more frequently, usually as a result of alcohol consumption. In doing so, they endanger their personal health and create challenges for EMS and local hospitals. This study examined EMS use by young adults (ages 16-24 years) to identify differences between university students and youth in the Region of Waterloo, and to determine predictors of transport to hospital. This cross-sectional study used retrospective data collected during a six-year period (2006-2011) from a large, mixed urban and rural municipal ambulance service located in southwestern Ontario. Data were extracted from …

The Felt Sense Of Interconnectedness: A Qualitative Analysis Of Perceptions On Finding Resilience In The Aftermath Of Trauma Using The Mind-Body Connections Of Yoga, Ashley Collette

Theses and Dissertations (Comprehensive)

Members and veterans of the military are at an increased risk of exposure to traumatic experiences due to the very nature of their occupation. The most recent statistics on Canada’s deployment to Afghanistan show that 13.2% of the (Canadian Armed Forces (CAF) members deployed have been diagnosed with a mental injury within a five year follow up period of redeployment from the theatre of operations. The present preliminary study was designed to examine Yoga as a therapeutic intervention for trauma in a population of CAF members and veterans. The author interviewed 4 service providers and 2 service users of Yoga-based …