Medicine and Health Sciences Commons^™

Missing Photos, Suffering Withdrawal, Or Finding Freedom? How Experiences Of Social Media Non-Use Influence The Likelihood Of Reversion, Eric P.S. Baumer, Shion Guha Phd, Emily Quan, David Mimno, Geri K. Gay

Health Services and Informatics Research

This article examines social media reversion, when a user intentionally ceases using a social media site but then later resumes use of the site. We analyze a convenience sample of survey data from people who volunteered to stay off Facebook for 99 days but, in some cases, returned before that time. We conduct three separate analyses to triangulate on the phenomenon of reversion: simple quantitative predictors of reversion, factor analysis of adjectives used by respondents to describe their experiences of not using Facebook, and statistical topic analysis of free-text responses. Significant factors predicting either increased or decreased likelihood of reversion …

This Digital Life: A Neighborhood-Based Study Of Adolescents' Lives Online, Jessica Pater Phd, Andrew D. Miller, Elizabeth Mynatt

Health Services and Informatics Research

In Proceedings of the 33rd Annual ACM Conference on Human Factors in Computing Systems.

In this paper, we present the results of a multi-year study of the social computing practices of 179 adolescents (Mage=12.4 years, SD=1.3; range: 10-14) living in a majority-minority lower-income urban neighborhood in the Southeast U.S. We investigate shifting social media practices using annual surveys and focus groups. We describe participants’ social media use and motivations and show how that use has shifted over time. We show how participants identify social pressures and influences as well as specific behaviors including computer-mediated risky behaviors and self-harm. We discuss …

Consanguinity And Pregnancy Outcomes In A Multi-Ethnic, Metropolitan European Population, Rolf Becker, Thomas Keller, Rolf-Dieter Wegner, Heidemarie Neitzel, Markus Stumm, Ute Knoll, Markus Stärk, Heiner Fangerau, Alan Bittles

Research outputs 2014 to 2021

Objective: The aim of the present study was to assess the risk of major anomalies in the offspring of consanguineous couples, including data on the prenatal situation. Methods: Over 20years (1993-2012), 35391 fetuses were examined by prenatal sonography. In 675 cases (1.9%), parents were consanguineous, with 307 couples (45.5%) related as first cousins, 368 couples (54.5%) beyond first cousins. Detailed information was retrieved on 31710 (89.6%) fetuses, (consanguineous 568: 1.8%). Results: Overall prevalence of major anomalies among fetuses with non-consanguineous parents was 2.9% (consanguineous, 10.9%; first cousins, 12.4%; beyond first cousins, 6.5%). Adjusting the overall numbers for cases having been …

Pre-Altitude Serum Ferritin Levels And Daily Oral Iron Supplement Dose Mediate Iron Parameter And Hemoglobin Mass Responses To Altitude Exposure, Daniel A. Galvao, Laura A. Garvican-Lewis,, Chris R. Abbiss, Peter Peeling, Christopher J. Gore

Research outputs 2014 to 2021

Purpose : To investigate the influence of daily oral iron supplementation on changes in hemoglobin mass (Hb_mass) and iron parameters after 2–4 weeks of moderate altitude exposure.Methods :Hematological data collected from 178 athletes (98 males, 80 females) exposed to moderate altitude (1,350–3,000 m) were analysed using linear regression to determine how altitude exposure combined with oral iron supplementation influenced Hb_mass, total iron incorporation (TII) and blood iron parameters [ferritin and transferrin saturation (TSAT)]. Results :Altitude exposure (mean ± s: 21 ± 3 days) increased Hb_mass by 1.1% [-0.4, 2.6], 3.3% [1.7, 4.8], and 4.0% …

Effects Of Estrogens On Adipokines And Glucose Homeostasis In Female Aromatase Knockout Mice, Michelle L. Van Sinderen, Gregory R. Steinberg, Sebastian B. Jørgensen, Jane Honeyman, Jenny D. Chow, Kerrie A. Herridge, Amy L. Winship, Evdokia Dimitriadis, Margaret E.E. Jones, Evan R. Simpson, Wah C. Boon

Research outputs 2014 to 2021

The maintenance of glucose homeostasis within the body is crucial for constant and precise performance of energy balance and is sustained by a number of peripheral organs. Estrogens are known to play a role in the maintenance of glucose homeostasis. Aromatase knockout (ArKO) mice are estrogen-deficient and display symptoms of dysregulated glucose metabolism. We aim to investigate the effects of estrogen ablation and exogenous estrogen administration on glucose homeostasis regulation. Six month-old female wildtype, ArKO, and 17β-estradiol (E2) treated ArKO mice were subjected to whole body tolerance tests, serum examination of estrogen, glucose and insulin, ex-vivo muscle glucose uptake, and …

Circulating Melanoma Cell Subpopulations: Their Heterogeneity And Differential Responses To Treatment, Elin S. Gray, Anna L. Reid, Samantha Bowyer, Leslie Calapre, Kelvin Siew, Robert Pearce, Lester Cowell, Markus H. Frank, Michael Millward, Mel R. Ziman Dr

Research outputs 2014 to 2021

Metastatic melanoma is a highly heterogeneous tumor; thus, methods to analyze tumor-derived cells circulating in blood should address this diversity. Taking this into account, we analyzed, using multiparametric flow cytometry, the co-expression of the melanoma markers melanoma cell adhesion molecule and melanoma-associated chondroitin sulphate proteoglycan and the tumor-initiating markers ATP-binding cassette sub-family B member 5 (ABCB5), CD271, and receptor activator of NF-κβ (RANK) in individual circulating tumor cells (CTCs) from 40 late-stage (III-IV) and 16 early-stage (I-II) melanoma patients. CTCs were heterogeneous within and between patients, with limited co-expression between the five markers analyzed. Analysis of patient matched blood and …

South African Hiv-1 Subtype C Transmitted Variants With A Specific V2 Motif Show Higher Dependence On Aα4Β7 For Replication, Simone I. Richardson, Elin S. Gray, Nonhlanhla N. Mkhize, Daniel J. Sheward, Bronwen E. Lambson, Constantinos K. Wibmer, Lindi Masson, Lise Werner, Nigel Garrett, Jo A.S Passmore, Quarraisha A. Karim, Salim S.A. Karim, Carolyn Williamson, Penny L. Moore, L. Morris

Research outputs 2014 to 2021

Background: The integrin aα4β7 mediates the trafficking of immune cells to the gut associated lymphoid tissue (GALT) and is an attachment factor for the HIV gp120 envelope glycoprotein. We developed a viral replication inhibition assay to more clearly evaluate the role of aα4β7 in HIV infection and the contribution of viral and host factors. Results: Replication of 60 HIV-1 subtype C viruses collected over time from 11 individuals in the CAPRISA cohort were partially inhibited by antibodies targeting aα4β7. However, dependence on aα4β7 for replication varied substantially among viral isolates from different individuals as well as over time in some …

The Uyghur Population And Genetic Susceptibility To Type 2 Diabetes: Potential Role For Variants In Cdkal1, Jazf1, And Igf1 Genes, Manshu Song, Feifei Zhao, Longjin Ran, Mamatyusupu Dolikun, Lijuan Wu, Lijuan Ge, Hao Dong, Qing Gao, Yanchun Zhai, Ling Zhang, Yuxiang Yan, Fen Liu, Xinghua Yang, Xiuhua Guo, Youxin Wang, Wei Wang

Research outputs 2014 to 2021

Substantial evidence suggests that type 2 diabetes mellitus (T2DM) is a multi-factorial disease with a strong genetic component. A list of genetic susceptibility loci in populations of European and Asian ancestry has been established in the literature. Little is known on the inter-ethnic contribution of such established functional polymorphic variants. We performed a case-control study to explore the genetic susceptibility of 16 selected T2DM-related SNPs in a cohort of 102 Uyghur objects (51 cases and 51 controls). Three of the 16 SNPs showed significant association with T2DM in the Uyghur population. There were significant differences between the T2DM and control …

Interacting Factors Associated With Adult Male Drowning In New Zealand, James L. Croft, Chris Button

Research outputs 2014 to 2021

Objectives: i) to identify factors that contribute to the global trend of the higher incidence of male drowning relative to females, and; ii) to explore relationships between such factors from mortality data in New Zealand. Methods: Drownings from 1983 to 2012 were examined for: Age, Ethnicity, Site, Activity, Buoyancy and Alcohol. Conditional frequency tables presented as mosaic plots were used to assess the interactions of these factors. Results: Alcohol was involved in a high proportion of Accidental Immersion drownings (61%) and was highest for males aged 20-24 years. When alcohol was involved there were proportionally more incidences where a life …

Follow-Up Plasma Apolipoprotein E Levels In The Australian Imaging, Biomarkers And Lifestyle Flagship Study Of Ageing (Aibl) Cohort, Veer B. Gupta, V.B, Andrea C. Wilson, Samantha Burnham, Eugene Hone, Steve Pedrini, Simon M. Laws, Wei L.F. Lim, Alan Rembach, Stephanie Rainey-Smith, David Ames, Lynne Cobiac, S L. Macaulay, Colin L. Masters, Christopher C. Rowe, Ashley I. Bush, Ralph Martins, Aibl Research Group

Research outputs 2014 to 2021

Introduction: Alzheimer's disease (AD) is a growing socioeconomic problem worldwide. Early diagnosis and prevention of this devastating disease have become a research priority. Consequently, the identification of clinically significant and sensitive blood biomarkers for its early detection is very important. Apolipoprotein E (APOE) is a well-known and established genetic risk factor for late-onset AD; however, the impact of the protein level on AD risk is unclear. We assessed the utility of plasma ApoE protein as a potential biomarker of AD in the large, well-characterised Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL) cohort. Methods: Total plasma ApoE levels were …

Mechanisms Contributing To Differential Regulation Of Pax3 Downstream Target Genes In Normal Human Epidermal Melanocytes Versus Melanoma Cells, Danielle Bartlett, Glen M. Boyle, Mel Ziman, Sandra Medic

Research outputs 2014 to 2021

Melanoma is a highly aggressive and drug resistant form of skin cancer. It arises from melanocytes, the pigment producing cells of the skin. The formation of these melanocytes is driven by the transcription factor PAX3 early during embryonic development. As a result of alternative splicing, the PAX3 gene gives rise to eight different transcripts which encode isoforms that have different structures and activate different downstream target genes involved in pathways of cell proliferation, migration, differentiation and survival. Furthermore, posttranslational modifications have also been shown to alter the functions of PAX3.We previously identified PAX3 downstream target genes in melanocytes and melanoma …

Prevalence And Associated Factors Of Myopia In High-School Students In Beijing, Li J. Wu, Qi S. You, Jia L. Duan, Yan X. Luo, Li J. Liu, Xia Li, Qi Gao, Hui P. Zhu, Yan He, Liang Xu, Jost B. Jonas, Wei Wang, Xiu H. Guo

Research outputs 2014 to 2021

Purpose : To evaluate prevalence and associated factors for myopia in high school students in Beijing. Methods : Grade 10 and 11 high school students were randomly selected from nine randomly selected districts of Beijing. The students underwent non-cylcoplegic auto-refractometry and an interview. Results : Out of 4798 eligible students, 4677 (93.4%) students (mean age:16.9±0.7years;range:16–18 years) participated. Mean refractive error of right eyes and left eyes was −2.78±2.29 diopters and −2.59±2.50 diopters, respectively. Prevalence of myopia (defined as ≤ −1.00 diopters in the worse eye) was 80.7% (95% Confidence Interval (CI): 79.6–81.8%). Out of 3773 students with myopia, 1525 (40.4%) …

A Comparative Evaluation Of The Learner Centered Grading Debriefing Method In Nursing Education, Marisa J. Belote

USF Tampa Graduate Theses and Dissertations

The nursing discipline lacks a consensus on a best practice method for debriefing students following simulation-based training. A recognized, standardized method does not exist and various methods are utilized within the domain. The similarities between aviation and healthcare are well documented. Training members of both disciplines require standardization and methods of best practice. The aviation industry through the Federal Aviation Administration has found Learner Centered Grading (LCG) to be a successful educational format. The utilization of the LCG Debriefing method in simulation-based training is the standardized debriefing format for a technologically dynamic industry.

The aim of this research was to …

Sound Attenuation Performance Of Fiber-Reinforced Polymer Composite Circumaural Hearing Protection Devices, Steven Christopher Augustine

USF Tampa Graduate Theses and Dissertations

Personnel who work on the flight deck of an aircraft carrier are exposed to extreme levels of jet engine noise often in excess of 140 decibels (dB). The current circumaural hearing protective devices (CAHPD) employed by flight deck crewmen are inadequate for the level of protection required for these extreme levels of noise. Fiber-reinforced thermoset polymer composite (FRPC) materials such as aramid fibers used in body armor, have high theoretical values of acoustic impedance due to a fundamentally high modulus of elasticity and may offer a superior level of hearing protection over original equipment (OE) thermoplastic CAHPDs. The objective of …

Anticipatory Coarticulation And Stability Of Speech In Typically Fluent Speakers And People Who Stutter Across The Lifespan: An Ultrasound Study, Alissa Joy Belmont

USF Tampa Graduate Theses and Dissertations

This study uses ultrasound to image onset velar stop consonant articulation in words. By examining tongue body placement, the extent of velar closure variation across vowel contexts provides for the measurement of anticipatory coarticulation while productions within the same vowel context provide measurement of extent of token-to-token variation. Articulate Assistant Advanced 2.0 software was used to semi-automatically generate midsagittal tongue contours at the initial point of maximum velar closure and was used to fit each contour to a curved spline. Patterns of lingual coarticulation and measures of speech motor stability, based on curve-to-curve distance (Zharkova, Hewlett, & Hardcastle, 2011), are …

Validity Testing Of A Preschool Reading Screening Device For Pediatricians, Erika Elaine Blue

USF Tampa Graduate Theses and Dissertations

Despite efforts to improve access to early literacy intervention in the United States, there are still children entering kindergarten that are not adequately prepared for school and are unlikely to catch up to their peers (National Education Association, 2014). Preschool programs are actively involved in screening their students for potential literacy difficulties; however, there are children who do not attend preschool and may not have their literacy development assessed. One solution to this problem is to involve other individuals who routinely see preschool age children. Pediatricians are one such group as children come to them for their wellness visits and …

Sleep, Depressive Symptoms And Cognition In Older Adults And Caregivers Of Persons With Dementia, Glenna Shemida Brewster

USF Tampa Graduate Theses and Dissertations

Caregivers of persons with dementia, who are often older adults, report sleep disturbance, high rates of depressive symptoms and may be at risk for impaired cognition. This dissertation examined sleep, depressive symptoms, and cognition in older adults and caregivers of persons with dementia. The aims of the review of literature were to understand, in community dwelling adults 60 years and older, the relationships among sleep parameters (sleep onset latency, wake after sleep onset, sleep efficiency, total sleep time, and general sleep complaints), and the domains of cognition (Executive Function, Attention, Episodic Memory, Working Memory, Processing Speed), and global cognition. Based …

Sigma Receptor Activation Mitigates Toxicity Evoked By The Convergence Of Ischemia, Acidosis And Amyloid-Beta, Adam Alexander Behensky

USF Tampa Graduate Theses and Dissertations

Stroke is the fifth leading cause of death in the United States and a major cause of long-term disability in industrialized countries. The core region of an ischemic stroke dies within minutes due to activation of necrotic pathways. Outside of this core region is the penumbral zone, where some perfusion is maintained via collateral arteries. Delayed cell death occurs in this area due to the triggering of apoptotic mechanisms, which expands the ischemic injury over time. The cellular and molecular events that produce the expansion of the ischemic core continue to be poorly understood. The increases in the amyloid precursor …

Exploring The Underlying Mechanisms Of Comorbid Adhd And Eating Disorders, Jennifer Rebecca Bleck

USF Tampa Graduate Theses and Dissertations

Evidence suggests comorbidity of ADHD and eating disorders (EDs) among females. Capitalizing on the comorbidity of ADHD and EDs and subsequent obesity could lead to improved prevention and treatment of all three conditions. However, additional information regarding the comorbidity is necessary to develop such interventions, as little is known about how or why this co-occurrence exists. A comprehensive model of the underlying mechanisms associated with comorbid ADHD and EDs is needed to improve understanding of the development of the comorbidity. Moreover, while there are gender differences within each disorder, literature is limited regarding to the comorbidity among males, leading to …

The Relation Between Adiposity And Anxiety In Youth: Analysis Of Peer Victimization, Teasing, Sociocultural Influences, And Internalization Of Appearance Ideals As Explanatory Variables, Natasha L. Burke

USF Tampa Graduate Theses and Dissertations

The purpose of the current study was to examine putative mediators and moderators in the association between adiposity and anxiety in a sample of overweight and obese youth. In addition, anxiety was examined as a potential moderator between adiposity and health-related quality of life (HRQOL). Participants were youth (N = 137) between 8 and 17 years old (M = 13.09, SD = 2.61) and their legal caregivers recruited from four medical clinics affiliated with the University of South Florida. Youth were primarily overweight (28.5%) or obese (64.2%) and ethnically diverse. Data were analyzed by path analysis. Weight-related teasing significantly mediated …

Genome-Wide Scans Detect Adaptation To Aridity In A Widespread Forest Tree Species, Dorothy A. Steane, Brad M. Potts, Elizabeth Mcclean, Suzanne M. Prober, William D. Stock, René E. Vaillancourt, Margaret Byrne

Research Datasets

Patterns of adaptive variation within plant species are best studied through common garden experiments, but these are costly and time-consuming, especially for trees that have long generation times. We explored whether genome-wide scanning technology combined with outlier marker detection could be used to detect adaptation to climate and provide an alternative to common garden experiments. As a case study, we sampled nine provenances of the widespread forest tree species, Eucalyptus tricarpa, across an aridity gradient in southeastern Australia. Using a Bayesian analysis we identified a suite of 94 putatively adaptive (outlying) sequence-tagged markers across the genome. Population-level allele frequencies of …

Latino Immigrant Workers’ Search For Justice After Occupational Injury, Carla Gabriela Castillo

USF Tampa Graduate Theses and Dissertations

Latino immigrants encounter an entanglement of rights and policies after occupational injury or illness. In collaboration with an immigrant worker center, ethnographic research and a survey are used to analyze injured workers’ experiences. The center uses survey results to identify common threads and systematic problems, and to explore potential direct action. Through interviews with workers and medical and legal professionals, I investigate the barriers Latino immigrants face following occupational injury or illness, how their lived experiences relate to the greater medicolegal frameworks that demarcate most formal processes of compensation and treatment, and the experiences of professionals who mediate these structures. …

Script Training: The Role Of Written Cues, Hallie Cohen

USF Tampa Graduate Theses and Dissertations

Script training is a technique that allows persons with acquired speech and language disorders, such as nonfluent aphasia, to have islands of fluent speech during which they can speak about a topic without pausing or having word-finding errors. Scripts relevant to specific functional situations are written and practiced until memorized. Script training delivered verbally has been effective with clients with aphasia but the role of written cues in the training has not been explored. Therefore the purpose of this study was to compare the effectiveness of script training taught verbally, or verbally with a written script, in persons with aphasia. …

Strategies For Preventing Age And Neurodegenerative Disease-Associated Mitochondrial Dysfunction, Vedad Delic

USF Tampa Graduate Theses and Dissertations

Mitochondrial dysfunction plays a pivotal role in the development of aging phenotypes and aging-associated neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Amyotrophic lateral sclerosis (ALS). Strategies that restore mitochondrial dysfunction may rescue the deficits of central metabolism in these disorders and improve cell survival. For example, we found that modulating the mTOR signaling pathway in a tissue culture model of aging-induced mitochondrial DNA mutation enhanced mitochondrial function as evidenced by increased oxygen consumption. Our previous melatonin studies also led us to hypothesize that caloric restriction and the hormone melatonin would reverse brain mitochondrial dysfunction in animal …

Effects Of Occupational Stressors On Nurses’ Safety Performance And Well-Being: A Within-Individual Study, Xinxuan Che

USF Tampa Graduate Theses and Dissertations

Occupational stressors have been extensively studied as predictors of safety performance and employee well-being in previous research. However, many newly introduced organizational constructs that have the characteristics of an occupational stressor have rarely been studied as such, especially from a within-person perspective. The current study focused on three occupational stressors in relation to safety performance. Based on previous literature, I proposed that within individuals, compulsory citizenship behavior, illegitimate tasks, and interpersonal conflict at work as occupational stressors would have negative effects on employees well-being and safety performance through negative emotions (anger), job attitudes (job satisfaction and organizational commitment) and role …

Maternal Stress, Breastmilk Igf-1, And Offspring Growth Among Breastfeeding Mothers-Infant Pairs In The Tampa Bay Area, Lauren Michelle Gottfredson

USF Tampa Graduate Theses and Dissertations

Background: Maternal stress during utero has been shown to have negative health consequences on the offspring, including low birth weight and increased risk of adult disease. Variation in breastmilk may act as an environmental cue of maternal stress and continue to program the infant during early life. This research aimed to explore the role of breastmilk on developmental programming of the infant. Specifically, to examine how breastmilk may act as a medium for the exposure of stress between the mother and the offspring, and see if variation in insulin like growth factor-1 (IGF-1) a potential mechanism for the relationship.

Methods: …

Mmv Malaria Box Activity Screening In Dormant Plasmodium Falciparum Phenotypes, Sandra Galusic

USF Tampa Graduate Theses and Dissertations

The causative agent of malignant tertian malaria, Plasmodium falciparum undergoes an arrested growth phenotype of its erythrocytic stage when under drug-stress. Recent artemisinin treatment failures seem to be indicative of such induction followed by recrudescence rather than actual therapeutic failure. Likewise, P. vivax hypnozoites are the prototypic dormants and the latent infections for which they are responsible prove most difficult to treat. Dihydroartemisinin, an artemisinin-derivative, can be used to exploit this mechanism by inducing a dormant state in ring-stage P. falciparum parasites and in turn, their recovery may be used as a screening period for compounds that inhibit or foster …

Mindfulness Attributes As Predictors Of Treatment Outcomes In Children Who Stutter, Jenna Lee Graepel

USF Tampa Graduate Theses and Dissertations

A recent U.S.-based survey (Boyle et al,. 2011) estimated stuttering prevalence in American children ages 3-17 years at 1.6% or 1 in 63 children. In comparison to the reported 1 in 68 school age children living with Autism Spectrum Disorder (Centers for Disease Control and Prevention, 2010), stuttering affects nearly as many. These estimates suggest that Speech-Language Pathologist (SLPs) should increasingly develop their skill sets for identifying and providing interventions for children who stutter.

The evidence base for school-age fluency intervention, while promising, leaves much room for further development (Nippold, 2011). The majority of current interventions revolve around the traditional …

Minocycline Treatment And The Necessity To Develop A Novel Outcome Measure For Children With Angelman Syndrome, Joseph Christopher Grieco

USF Tampa Graduate Theses and Dissertations

Angelman syndrome (AS) is a rare genetic disorder affecting 1/10,000 to 1/20,000 births. This disorder arises through the genetic disruption of the maternal UBE3A allele, which when coupled with epigenetic silencing of the paternal allele UBE3A allele, gives rise to an absence of UBE3A protein in the central nervous system. Clinical manifestations of the syndrome vary in severity and include poor motor function, deficits in language and severe intellectual impairments. Previous research in the Angelman syndrome mouse model revealed abnormalities in dendritic spine density and morphology of hippocampal pyramidal cells. As seen in humans with AS, mice show abnormal behavioral …

Immunological Characterization Of Duffy Binding Protein Of Plasmodium Vivax, Miriam Thankam George

USF Tampa Graduate Theses and Dissertations

Plasmodium vivax Duffy binding protein (DBP) is an essential ligand for reticulocyte invasion making it a premier asexual blood stage vaccine candidate. However, strain-specific immunity due to DBPII allelic variation may complicate vaccine efficacy, suggesting that an effective DBPII vaccine needs to target immune responses to conserved epitopes that are potential targets of strain-transcending neutralizing immunity. Anti DBPII monoclonal antibodies, which were previously characterized by COS7 cell binding assay as inhibitory and non-inhibitory to DBPII-erythrocyte binding, were mapped to DBPII gene fragment libraries using phage display. Inhibitory mAb 3C9 binds to a conserved conformation-dependent epitope in subdomain 3 while non-inhibitory …