Medicine and Health Sciences Commons^™

Crizotinib: A Tyrosine Kinase Inhibitor, Graham Mclaren

Honors Theses

Crizotinib is a small molecule tyrosine kinase inhibitor that is currently being marketed by Pfizer under the trade name Xalkori^®. After its development in 2005, an appropriate target was discovered in 2007. By 2011 the FDA had approved crizotinib for use in patients with ALK+ non small cell lung cancer (NSCLC). ALK+ NSCLC is caused by a genetic mutation that truncates and flips a section of the EML4 gene and attaches it to a section of the ALK gene. The result is the EML4-ALK oncogene. The resulting protein from this mutation is capable of undergoing ligand independent dimerization, …

Kromium, Timbal, Dan Merkuri Dalam Air Sumur Masyarakat Di Sekitar Tempat Pembuangan Akhir Sampah, Taufik Ashar, Devi Nuraini Santi, Evi Naria

Kesmas

Tempat pembuangan akhir (TPA) sampah domestik dengan sistem penampungan terbuka sangat berisiko mencemari air tanah milik warga yang bermukim di sekitarnya melalui proses perlindian. Untuk mengetahui kandungan logam berat dalam air tanah di sekitar TPA, sebanyak 68 sampel air sumur gali (45 sumur Dusun I dan 23 sumur Dusun IV) dari Desa Namobintang Kecamatan Pancurbatu Kabupaten Deli Serdang, Sumatera Utara, telah dianalisis dengan inductively couple plasma atomic emission spectroscopy. Hubungan jarak sumur dengan konsentrasi kromium, merkuri, dan timbal diuji dengan Mann-Whitney, Spearman’s Correlation dan analisis regresi linier sederhana. Hasil penelitian menunjukkan konsentrasi kromium, timbal, dan merkuri (rerata ± deviasi standar, …

Deskripsi Sanitasi Lingkungan, Perilaku Ibu, Dan Kesehatan Anak, Kasnodihardjo Kasnodihardjo, Elsa Elsi

Kesmas

Pada tahun 2009, dilakukan penelitian deskriptif di Kecamatan Jatibarang dan Kecamatan Kedokan Bunder untuk mengetahui faktor-faktor sanitasi lingkungan, dan perilaku ibu-ibu dan kejadian penyakit infeksi pada bayi dan anak. Data dikumpulkan menggunakan kuesioner dengan responden ibu rumah tangga yang mempunyai bayi/ anak balita berjumlah 401 orang. Penyakit diare pada bayi/anak disebabkan oleh media tercemar yang masuk ke sistem pencernaan melalui sumber air untuk minum maupun mandi, cuci, kakus (MCK) yang bukan berasal dari ledeng, keluarga yang tidak mempunyai jamban, ibu yang masih jarang mencuci tangan setelah membersihkan kotoran bayi ataupun setelah buang air besar, meminum dan memakan makanan yang tidak …

Perilaku Remaja Putri Menghadapi Menarche Berdasarkan Nilai Budaya Batak, Merida Simanjuntak, Suryani Manurung, Tri Riana Lestari, Payung Hasibuan

Kesmas

Masa remaja merupakan masa transisi dari masa kanak-kanak menuju masa dewasa yang ditandai oleh perubahan fisik, intelektual, seksual, dan emosional. Menarche pada remaja putri menjadi pertanda memasuki tahapan sistem reproduksi dewasa. Sesuai dengan nilai dan budaya masyarakat, peristiwa menstruasi pertama yang fisiologis itu mendapat respons yang berbeda. Tujuan penelitian ini adalah mengembangkan kerangka teoritis tentang pola perilaku remaja putri dalam menghadapi menarche sesuai dengan nilai dan budaya keluarga Batak di Jakarta. Penelitian kualitatif ini dilakukan dengan pendekatan grounded theory dengan metode pengumpulan data melalui wawancara mendalam, observasi, dan studi literatur. Enam orang informan direkrut dengan cara purposive sampling di wilayah …

Promosi Pengetahuan, Sikap, Dan Keterampilan Berpola Hidup Sehat Pada Kelompok Senam, L. Meily Kurniawidjaja, Dadan Erwandi, Ike Pujiriani

Kesmas

Pendirian grup senam masyarakat perkotaan sering dipicu oleh ancaman penyakit jantung koroner dan stroke (penyakit kardiovaskular). Banyak diantara mereka masih berisiko tinggi penyakit kardiovaskular antara lain berat badan lebih dan kadar kolesterol tinggi serta faktor umur dan genetik, tetapi faktor risiko penyakit kardiovaskular dapat diturunkan dengan pola hidup sehat. Tujuan penelitian ini adalah menilai pengaruh metode promosi kesehatan dengan pendekatan siklus rekognisi, analisis, perencanaan, komunikasi, persiapan, implementasi, evaluasi, dan kelanjutan dapat meningkatkan pengetahuan, sikap dan praktik ibu-ibu pesenam tentang pola hidup sehat. Penelitian ini menggunakan pretest and posttest design untuk menilai hasil intervensi pada 60 orang berusia rata-rata 58,26 tahun …

Cavin1; A Regulator Of Lung Function And Macrophage Phenotype., Praveen Govender, Freddy Romero, Dilip Shah, Jesus Paez, Shi-Ying Ding, Libin Liu, Adam Gower, Elizabeth Baez, Sherif Shawky Aly, Paul Pilch, Ross Summer

Center for Translational Medicine Faculty Papers

Caveolae are cell membrane invaginations that are highly abundant in adipose tissue, endothelial cells and the lung. The formation of caveolae is dependent on the expression of various structural proteins that serve as scaffolding for these membrane invaginations. Cavin1 is a newly identified structural protein whose deficiency in mice leads to loss of caveolae formation and to development of a lipodystrophic phenotype. In this study, we sought to investigate the functional role of Cavin1 in the lung. Cavin1 deficient mice possessed dramatically altered distal lung morphology and exhibited significant physiological alterations, notably, increased lung elastance. The changes in distal lung …

The Quality Of Life Of Families Of Children With Cerebral Palsy, Jill A. Wippermann

Senior Honors Theses

Cerebral palsy, the most common cause of physical childhood disability, is a non-progressive disorder that results from an anoxic brain injury to the fetal or newborn brain. Because this disorder can cause disability, ranging from mild to severe effects on motor and cognitive functioning, the diagnosis can vary from one child to another, causing family stress due to vague and unknown predicted outcomes of the disorder. Because the diagnosis of cerebral palsy affects families in different ways depending on coping mechanisms, support systems, and the age and level of functioning of the child, among other factors, it is important to …

Identifikasi Vektor Malaria, Solikhah Solikhah

Kesmas

Kabupaten Kulonprogo merupakan salah satu daerah endemis malaria di Daerah Istimewa Yogyakarta dan Jawa Tengah. Lonjakan jumlah kasus malaria terjadi hampir dua kali lipat sejak tahun 2010 hingga bulan Agustus 2011. Penelitian ini bertujuan untuk mengetahui jenis Plasmodium pada penyakit malaria. Penelitian eksplorasi ini menggunakan desain studi cross sectional. Diagnosis kasus malaria diperiksa menggunakan pemeriksaan darah tebal secara mikroskopis dan untuk mengetahui faktor sosiodemografi dilakukan wawancara menggunakan kuesioner. Populasi studi adalah penduduk di wilayah Kabupaten Kulonprogo yang diambil secara proporsional pada bulan Januari sampai bulan Juni 2012. Data dianalisis secara univariat dalam bentuk grafik dan tabulasi. Hasil penelitian ini adalah …

Understanding Molecular Interactions: Application Of Hint-Based Tools In The Structural Modeling Of Novel Anticancer And Antiviral Targets, And In Protein-Protein Docking, Hardik Parikh

Theses and Dissertations

Computationally driven drug design/discovery efforts generally rely on accurate assessment of the forces that guide the molecular recognition process. HINT (Hydropathic INTeraction) is a natural force field, derived from experimentally determined partition coefficients that quantifies all non-bonded interactions in the biological environment, including hydrogen bonding, electrostatic and hydrophobic interactions, and the energy of desolvation. The overall goal of this work is to apply the HINT-based atomic level description of molecular systems to biologically important proteins, to better understand their biochemistry – a key step in exploiting them for therapeutic purposes. This dissertation discusses the results of three diverse projects: i) …

A Key New Ally In The Search For Huntington’S Disease Treatments, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Bryant University Research And Engagement Day Program

Bryant REDay (Research and Engagement Day)

No abstract provided.

A Home-Based Exercise Program For The Foot And Ankle To Improve Balance, Muscle Performance And Flexibility In Community Dwelling Older Adults: A Pilot Study, Laurel Long, Kurt Jackson, Lloyd L. Laubach

Physical Therapy Faculty Publications

Background and purpose: Strength and range of motion of the foot and ankle have been shown to be related to measures of balance and fall risk in older adults. The primary purpose of this pilot investigation was to evaluate the feasibility of a 6-week home-based exercise program focusing on the foot and ankle and any associated changes in balance, muscle performance and range of motion in older adults. Methods: This single-group repeated measures study involved a convenience sample of 21 healthy communitydwelling older adults age 60-90. Nineteen participants completed all phases of the testing and training. The intervention was a …

A Community-Based Oral Health Self-Care Intervention For Hispanic Families, Pamela C. Hull, Michelle C. Reece, Marian Patton, Janice Williams, Bettina M. Beech, Juan R. Canedo, Roger J. Zoorob

Dental Hygiene Faculty Research

Objectives

A community-based intervention is described that targets oral health self-care practices among Hispanic children in the United States and is being tested in an ongoing trial. Descriptive results of baseline oral health variables are presented.

Methods

As of January 2013, 284 Hispanic children of ages 5–7 enrolled in the Healthy Families Study in Nashville, TN, USA. Families are randomized to one of two culturally appropriate interventions.

Results

At baseline, 69.6 % of children brushed at least twice daily, and 40.6 % brushed before bed daily. One-third of parents did not know if their children’s toothpaste contained fluoride.

Conclusions

This …

April 24, 2013, Communication Disorders & Sciences

Faculty Meeting Minutes & Agendas

Meeting minutes of the April 24, 2013 Faculty Committee meeting.

Our Diversity Is What Will Drive New Levels Of Excellence, Lisa Barkley

UCF Forum

Diversity has changed and the face of America has changed. As a nation, we have to come to grips with the reality that our melting pot has never had so many ingredients mixed in – and we are never going back to what it used to be.

The Effects Of Question Placement On Reading Comprehension Scores Of High Comprehenders, Katharine Beideck, Kristen Bartlett, Jessica Kuiphoff, Jane Biedron, Shemika Cookbey, Thomas Sutherlin, Katelyn Staples

Symposium on Research and Creative Expression (SORCE)

Previous research has shown that embedded questions hurt the reading comprehension of high comprehenders. All participants had high reading comprehension skills scoring at or above 66 percent on the ACT/SAT. Participants either read a packet with questions embedded about every paragraph or a packet where questions were all located at the end of the reading. Participants answered the questions as they came to them. After a week of delay, the participants came back and took a test with questions that were either: target, non-target, or related. For all of the dependent variables, people who had taken a statistics course before …

Opinions About Smoking, Secondhand Smoke Exposure, And Smoking Behaviors Of Freshmen College Students, Nathan Matejczyk, Nina Tu, Michelle De Young, Nicole Arena

Symposium on Research and Creative Expression (SORCE)

The purpose of this project was to assess first semester freshman college students’ opinions about smoking, secondhand smoke exposure, and smoking behaviors on a smoke-free campus. This research used an online cross-sectional survey. For two years, surveys were emailed via Zoomerang to all first semester freshmen students at Valparaiso University. Survey questions contained 60 forced-choice or open-ended options. Data were analyzed using descriptive statistics. A total of 630 students responded. Subjects were primarily female (58.4%) and Caucasian (84.9%). Twenty-five percent of the respondents reported being exposed to secondhand smoke in their environments. Twenty-nine percent were unaware that the campus is …

Health Literacy: Understanding Medication Labels, Jennifer Sechrist, Brittany O’Reilly, Katherine Jankauski, Emily Czekala, Lily Salinas

Symposium on Research and Creative Expression (SORCE)

Introduction: According to the Institute of Medicine (IOM), over 90 million people in the U.S. have difficulty understanding and using health information including medication labels. Purpose: To determine how individuals interpret medication labels and the relationship between medication label interpretation and level of health literacy. Method: Participants were recruited from a student-run health fair and a University Relay for Life. After securing consent, participants completed demographic information and the Rapid Estimate of Adult Literacy in Medicine (REALM). Participants were asked to blindly choose three medication containers from a bag. The labels were prepared by a registered pharmacist and affixed to …

The Stethoscoop, March 22, 2013, Mennonite College Of Nursing

The Stethoscoop

The Stethoscoop is the newsletter for Mennonite College of Nursing students.

Effects Of Perinatal Oxycodone Exposure On The Cardiovascular Response To Acute Stress In Male Rats At Weaning And In Young Adulthood, Thitinart Sithisarn, Henrietta S. Bada, Richard J. Charnigo, Sandra J. Legan, David C. Randall

Pediatrics Faculty Publications

Oxycodone (OXY) is one of the most commonly abused opiates during pregnancy. Perinatal opiate exposure (POE) is associated with neurobehavioral and hormone changes. Little is known about the effects of perinatal OXY on the cardiovascular (CV) responses to stress.

Objectives: to determine the effects of POE on: (1) CV responses to acute stress and ability to discriminate using a classical conditioning paradigm; (2) changes in CV response to the paradigm and retention of the ability to discriminate from postnatal day (PD) 40 to young adulthood.

Methods: Pregnant rats were given i.v. OXY or vehicle (CON) daily. OXY and CON males …

Automatic Block-Matching Registration To Improve Lung Tumor Localization During Image-Guided Radiotherapy, Scott Robertson

Theses and Dissertations

To improve relatively poor outcomes for locally-advanced lung cancer patients, many current efforts are dedicated to minimizing uncertainties in radiotherapy. This enables the isotoxic delivery of escalated tumor doses, leading to better local tumor control. The current dissertation specifically addresses inter-fractional uncertainties resulting from patient setup variability. An automatic block-matching registration (BMR) algorithm is implemented and evaluated for the purpose of directly localizing advanced-stage lung tumors during image-guided radiation therapy. In this algorithm, small image sub-volumes, termed “blocks”, are automatically identified on the tumor surface in an initial planning computed tomography (CT) image. Each block is independently and automatically registered …

Stemming The Global Trade In Falsified And Substandard Medicines, Lawrence O. Gostin, Gillian J. Buckley, Patrick W. Kelley

Georgetown Law Faculty Publications and Other Works

Drug safety and quality is an essential assumption of clinical medicine, but there is growing concern that this assumption is not always correct. Poor manufacturing and deliberate fraud occasionally compromises the drug supply in the United States, and the problem is far more common and serious in low- and middle-income countries with weak drug regulatory systems. An Institute of Medicine consensus committee report identified the causes and possible solutions to the problem of falsified and substandard drugs around the world.

The vocabulary people use to discuss the problem is itself a concern. The word counterfeit is often used innocuously to …

Microwave Imaging For Neoadjuvant Chemotherapy Monitoring: Initial Clinical Experience, Paul M. Meaney, Peter A. Kaufman, Lori S. Muffly, Michael Click, Stephen P. Poplack, Wendy A. Wells, Gary N. Schwartz, Roberta M. Di Florio-Alexander, Tor Tosteson, Zhongze Li, Shireen D. Geimer, Margaret W. Fanning, Tian Zhou, Neil R. Epstein, Keith D. Paulsen

Dartmouth Scholarship

Introduction:

Microwave tomography recovers images of tissue dielectric properties, which appear to be specific for breast cancer, with low-cost technology that does not present an exposure risk, suggesting the modality may be a good candidate for monitoring neoadjuvant chemotherapy.

Methods:

Eight patients undergoing neoadjuvant chemotherapy for locally advanced breast cancer were imaged longitudinally five to eight times during the course of treatment. At the start of therapy, regions of interest (ROIs) were identified from contrast-enhanced magnetic resonance imaging studies. During subsequent microwave examinations, subjects were positioned with their breasts pendant in a coupling fluid and surrounded by an immersed antenna …

The Nordinet® International Outcome Study And Novonet® Answer Program®: Rationale, Design, And Methodology Of Two International Pharmacoepidemiological Registry-Based Studies Monitoring Long-Term Clinical And Safety Outcomes Of Growth Hormone Therapy (Norditropin®)., Charlotte Höybye, Lars Sävendahl, Henrik Thybo Christesen, Peter Lee, Birgitte Tønnes Pedersen, Michael Schlumpf, John Germak, Judith Ross

Department of Pediatrics Faculty Papers

OBJECTIVE: Randomized controlled trials have shown that growth hormone (GH) therapy has effects on growth, metabolism, and body composition. GH therapy is prescribed for children with growth failure and adults with GH deficiency. Carefully conducted observational study of GH treatment affords the opportunity to assess long-term treatment outcomes and the clinical factors and variables affecting those outcomes, in patients receiving GH therapy in routine clinical practice.

DESIGN: The NordiNet® International Outcome Study (IOS) and the American Norditropin® Studies: Web Enabled Research (ANSWER Program®) are two complementary, non-interventional, observational studies that adhere to current guidelines for pharmacoepidemiological data.

PATIENTS: The studies …

A Case Study Exploring Restraint And Seclusion Use In School-Age Children On An Inpatient Psychiatric Unit, Michelle Buckman Phd

Dissertations

Perceptions of children restrained and secluded (R&S) were explored using Yin's methodology and critical theory. The literature presented reviewed proponent's and opponent's views of the R&S intervention used on inpatient psychiatric units for the containment of violent patients. Despite reports of physical and emotional injury to staff and patient during restraining and secluding children, the intervention is still in use. Using Machover's framework, a semi-structured interview and drawings were used to illicit information from a 12 year old boy about his perceptions of R&S. Then, a presentation of barriers to conducting research is made. Results of the child's perceptions included …

Sociodemographic Characteristics, Distance To The Clinic, And Breast Cancer Screening Results, Seijeoung Kim, Beverly Chukwudozie, Elizabeth Calhoun

Journal of Health Disparities Research and Practice

Timely detection and follow-up of abnormal cellular changes can aid in early diagnosis of breast cancer, thus leading to better treatment outcomes. However, despite substantial breast cancer screening initiatives, the proportion of female breast cancer cases diagnosed at late stages remains high. Distance to screening clinics may affect access to care, particularly for women living in impoverished areas with limited means of reliable transportation. Utilizing breast cancer screening data collected by the Illinois Breast and Cervical Cancer Program between 1996 and 2010, we examined the effect of travel distance to the clinic from which women received breast cancer screening tests …

The Effect Of Race/Ethnicity On The Age Of Colon Cancer Diagnosis, Matthew Katz, Maryann E. Parrish, Ellen Li, Yuanhao Zhang, Wei Zhu, Kenneth Shroyer, Roberto Bergamaschi, Jennie L. Williams

Journal of Health Disparities Research and Practice

ABSTRACT

BACKGROUND: Colorectal cancer is the third most commonly diagnosed cancer in the United States. Notably, racial/ethnic disparities exist in both incidence and mortality.

PURPOSE: The aim of this case study was to investigate the impact of race/ethnicity on age at diagnosis of colorectal cancer in a defined population in Suffolk County, NY.

METHODS: Data were retrospectively collected on race/ethnicity, health insurance status, age at diagnosis, stage at diagnosis, gender, smoking status, alcohol intake, tumor location, and body mass index for colorectal cancer patients with medical records in the Stony Brook University Medical Center database (2005-2011). Population-based data on Hispanic …

The Normative Dimensions Of Health Disparities, Andrew Ward, Pamela Jo Johnson, Mollie O'Brien

Journal of Health Disparities Research and Practice

Understanding what conditions must be satisfied for a health inequality to be a health inequity (disparity) is crucial for health policy makers. The failure to understand what constitutes a health inequity, and confusing health inequalities with health inequities threatens the successful creation of health policies by diverting needed attention and resources away from addressing health inequalities that are health inequities. More generally, the failure threatens to undercut our ability to tell what research is relevant to the creation of health policies that aim to mitigate or eliminate health inequities. With this in mind, the principal aim of the present paper …

Discrimination In Medical Settings And Attitudes Toward Complementary And Alternative Medicine: The Role Of Distrust In Conventional Providers, Tetyana Shippee, Carrie Henning-Smith, Nathan Shippee, Jessie Kemmick Pintor, Kathleen T. Call, Donna Mcalpine, Pamela Jo Johnson

Journal of Health Disparities Research and Practice

This study examines the relationship between racial/ethnic discrimination in medical settings, distrust in conventional medicine, and attitudes toward complementary and alternative medicine (CAM) among a racially/ethnically diverse sample. We also investigate how this relationship differs by nativity. Data are from a 2008 statewide stratified sample of publicly insured adults in Minnesota (N=2,194). Discrimination was measured as self-reported unfair treatment in medical settings due to race, ethnicity, and/or nationality. Outcomes are trust in conventional providers/medicine and attitudes toward CAM modalities. Discrimination in medical settings was positively associated with 1) distrust in conventional providers and 2) favorable attitudes toward CAM. Foreign-born …

A Diabetes Prevention Program Provided By Home Care Nurses To Residents Of Public Housing Communities, Robin Whittemore Phd, Alana Rosenberg Mph, Sangchoon Jeon Phd

Journal of Health Disparities Research and Practice

The purpose of this pilot study was 1) to modify the Diabetes Prevention Program protocol collaboratively with home care nurses, health professionals, and residents of public housing: 2) to evaluate the feasibility (reach and implementation) and the preliminary efficacy of the modified diabetes prevention program (mDPP) provided by home care nurses to adults at-risk for T2D on clinical, behavioral, and psychosocial outcomes compared to an enhanced standard care control group. A mixed-method sequential design was used. The sample (n=67) was primarily female (79%), with a mean age of 40 years, and of diverse race and ethnicity (76% non-White). Home care …