Medicine and Health Sciences Commons^™

A Case Of Hemoglobinopathy-Thalassemia Syndrome, Michele C. Khurana, B.S., Gene Gulati, Ph.D

Department of Pathology Honors Program Student Research Symposium

Patient Presentation

• 43 year-old African American female presents with left lower extremity pain
• Physical exam: unremarkable
• Past medical history:

Anemic since childhood

Avascular necrosis of left hip

DVT

Chronic illnesses: asthma, depression

Surgical history: appendectomy, tubal ligation, splenectomy, cholecystectomy, L hip replacement

• Family history: mother has lupus

Thoracic Dissecting Aneurysm And The Importance Of Genetics, Dan Kramer, Ba, Anthony Prestipino, M.D.

Department of Pathology Honors Program Student Research Symposium

Patient Presentation

• 28 year old white male with a past medical history significant for untreated hypertension
• Presents with 3 day history of chest discomfort, lower extremity weakness, bowel and bladder dysfunction, near-syncopal episodes
• Absent pulse in right femoral artery, weak pulse in left femoral artery
• Echosonography showed acute Type A dissecting aortic aneurysm
• Treatment

Immediately taken to surgery for repair of aorta with a graft and replacement of the aortic valve

• Outcome

Unstable after surgery

Biventricular heart failure

Persistent bleeding into mediastinum due to DIC

Required massive transfusion of RBCs, FFP, Cryoprecipitate, and Platelets

Became anuric and acidotic

Became fluid …

Adenoid Cystic Carcinoma In Unusual Locations – Differential Diagnosis Difficulties, Heather A. Mcmahon, B.S., Madalina Tuluc, Md

Department of Pathology Honors Program Student Research Symposium

Adenoid Cystic Carcinoma (ACC) is an uncommon malignant salivary gland tumor, representing 1% of all malignant tumors of the oral and maxillofacial region and 22% of all salivary gland malignancies. Although in the majority of cases ACC manifests in the major salivary glands, in rare instances it can be found in locations such as the esophagus, larynx, trachea, lacrimal gland, breast, prostate, lungs, or auditory canal. These unusual locations of ACC often pose a diagnostic challenge to the clinician and are associated with poorer outcomes for patients as compared to those ACC of a more typical presentation. In this study …

Correlations Between Gene Amplification And Protein Expression Of Topoisomerase 2a (Top2a) In Squamous Cell Carcinoma Of The Lung, Anita Modi, Msii, Charalambos C. Solomides, Md

Department of Pathology Honors Program Student Research Symposium

Background: While DNA topoisomerase 2A (TOP2A) plays an essential role in maintaining the structural integrity of the double helix during replication and recombination, excessive expression of this enzyme may promote malignant cell transformations. In fact, increased levels of TOP2A have been observed in various cancer cell lines including squamous cell carcinoma of the lung. This study sought to identify correlations between genotypic and phenotypic evidence of TOP2A obtained via in situ hybridization (ISH) and immunohistochemistry (IHC) techniques.

Methods Tissue microarrays created from 29 samples of Stage I Squamous Cell Carcinoma of the lung were stained with VENTANA BenchMark ULTRA platform …

Temporal Lobe Ganglioglioma In An Epilepsy Patient With Worsening Seizures: Case Study And Future Directions, Adam M. Olszewski, Mark Curtis, Md Phd.

Department of Pathology Honors Program Student Research Symposium

Gangliogliomas are rare brain tumors that have both neuronal and glial components. They hold a better prognosis than other infiltrative glial tumors, but differentiating between them can be challenging. While molecular markers are being studied, it is currently a histologic diagnosis.

In this case, the patient presented with epilepsy and worsening seizures secondary to a medial temporal lobe mass. Radiology report was inconclusive. Surgical resection was achieved and based on histologic examination the lesion was diagnosed as ganglioglioma, WHO grade I.

In this patient, pathological diagnosis of ganglioglioma offers a favorable prognosis and low risk of recurrence. In the future, …

Diagnostic Yield Of Endobronchial Ultrasound-Guided Fine Needle Aspiration (Ebus-Fna) In Lung Cancer Staging, Subtyping And Diagnosis Of Unexplained Mediastinal Lymphadenopathy, Rino Sato, Rossitza Draganova-Tacheva, Md

Department of Pathology Honors Program Student Research Symposium

INTRODUCTION

• Lung cancer (LC) is the most commonly diagnosed cancer worldwide and the most frequent cause of cancer death in both men and women in the US (more deaths than the next three most common cancers combined)¹
• Clinical staging of LC is an integral part of patient care because it directs therapy and has prognostic value

Patients are routinely investigated with a conventional workup (medical history, PE, lab tests, bronchoscopy), CT and integrated whole-body PET-CT, followed by mediastinal tissue staging for enlarged or PET-positive intrathoracic nodes²

• Mediastinal tissue staging has been classically performed by mediastinoscopy, but they can …

Melanocytoma Of The Cerebellopontine Angle, Pranay Soni, M.D, Lawrence C. Kenyon, Md, Phd

Department of Pathology Honors Program Student Research Symposium

Ms. M.G. is a 46-year-old woman with a history of hypertension and prior bilateral laser eye surgery. In 2009, she presented with vertigo, tinnitus, and decreased hearing in the left ear. An MRI scan revealed an enhancing mass in the posterior fossa that was thought to be an acoustic neuroma. In May of 2009, she underwent gamma-knife radiotherapy for the 2.7 cm mass.

In September of 2012, M.G. noted progressive change in her voice quality as well as a swallowing disturbance and left facial spasms. A subsequent MRI showed significant enlargement of the tumor to a maximal size of 3.7 …

The Value Of Public Health Financial Data, Glen P. Mays

Health Management and Policy Presentations

Effective policy and administrative decision-making in public health requires reliable information on the amount of resources invested in governmental public health programs and how these resouces are allocated and used across the U.S. public health system. This session examines current and potential uses of public health financial data in the U.S., and considers expanded roles for research in informing policy and administrative decisions.

Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (Dipnech) To Carcinoid: Exploring The Link, Jacob D. Mcfadden Msii, Jeffrey P. Baliff Md

Department of Pathology Honors Program Student Research Symposium

Neuroendocrine cells (NECs) play important roles in normal lung development, autonomic regulation of lung function, and response to hypoxia or injury. They are located between the respiratory epithelium and the basement membrane of bronchi and bronchioles (below), often as single cells or small clusters.

NEC proliferation is a common pathologic occurrence, well established as a reactive response to chronic lung injury. Much less commonly, NEC proliferation is observed in the absence of apparent inciting factors. This neoplastic phenomenon is termed “diffuse idiopathic pulmonary neuroendocrine cell hyperplasia” (DIPNECH).

DIPNECH is recognized as a precursor lesion for carcinoid tumors. While the progression …

Ocular Manifestations Of Rosai-Dorfman Disease, Phoebe L. Mellen, B.S., Ralph C. Eagle Jr., M.D.

Department of Pathology Honors Program Student Research Symposium

History of Rosai-Dorfman Disease

In 1969, Dr. Juan Rosai and Dr. Ronald F. Dorfman reported four cases of an entity that previously had puzzled pathologists and clinicians. The four cases had failed to fit under any diagnosis, but shared a few common characteristics. Each patient presented with painless, massive lymphadenopathy, most commonly of the cervical lymph nodes¹. Other locations included the inguinal, intra-parotid, and axillary lymph nodes. The patients all presented with fever and leukocytosis¹. The differential diagnosis included malignant lymphoma, malignant histiocytosis, reticuloendotheliosis, and chronic inflammation. However, the histopathological characteristics of the cases did not …

The Effects Of A Violence Assessment Checklist On The Incidence Of Violence For Emergency Department Nurses, Sarah Knapp

Evidence-Based Practice Project Reports

Workplace violence (WV) is commonplace in American culture, and nurses working in emergency departments (ED) are not immune to its effects. Violence against emergency department nurses is prominent in current nursing literature, and a cause for major concern. Regrettably there is no consistent tool being used to assess for potential patient violence specific to the emergency department. Current assessment tools have been developed and are commonly used in the mental health arena. This evidence-based practice project concentrated on answering the clinical question of whether or not a violence risk assessment checklist reduced the incidence of violence and increased perception of …

Chromosome-Specific Telomere Length In Women With Breast Cancer: Their Relationship To Chemotherapy And Acquired Psychoneurological Symptoms, Areej Alhareeri

Theses and Dissertations

Breast cancer (BC) is one of the most common diagnosed malignancies in females. Although 90% of early diagnosed women are expected to survive for at least 5 years, their quality of life is adversely affected by a cluster of symptoms which we collectively named “psychoneurological symptoms’’ (PN). Given that acquired telomere attrition has been speculated to be a causal factor in chronic diseases and the lack in the literature of mechanisms giving rise to PN symptoms, this study was performed to assess telomere length using a chromosome-specific telomere assay before receiving chemotherapy and at the first chemotherapy. We showed significant …

Effects Of Short-Term Minocycline Treatments On Inflammatory Cell Response In The Acute Stage Following Tbi, Henna Ayub

Theses and Dissertations

Following traumatic brain injury (TBI), neuroinflammation contributes to the secondary injury. Microglia are the resident immune cells of the central nervous system (CNS), and when activated can exert either protective or detrimental effects on surrounding tissue. They are often segregated into subpopulations based on their type of activation, either pro- inflammatory (M1, classically activated), or anti-inflammatory (M2, alternatively activated). Minocycline, an anti-inflammatory drug, is known to be neuroprotective and to have effect on microglia. However, the effect of minocycline on subpopulations of inflammatory cells in the acute stage following injury is unclear. It is also unclear whether minocycline has a …

Connecting Public Libraries With Community Emergency Responders, Michelle Malizia, Karen Vargas, Rebecca Hamilton, Deborah Littrell, Cynthia Olney

Library Staff Publications

No abstract provided.

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Risk Factors for Childhood blindness

The Path To Health Information Technology Adoption: How Far Have We Reached?, Pranav Gokhale

Muskie School Capstones and Dissertations

Health Information Technology (HIT) is an overarching framework that describes the management of health information across various computerized systems and the secure exchange between consumers, providers, government, and insurers. It has been viewed as a promising tool for improving the overall quality, safety and efficiency of the health delivery system (Chaudhry et al., 2006). This capstone examines the problem of urban rural divide in the process of Health IT adoption especially with regard to Electronic Health Records (EHRs). This paper also tracks the progress made during years 2009 to 2013 to the process of Electronic Health Record adoption in the …

Upper Extremity Vertical Ground Reaction Forces During The Back Handspring Skill In Gymnastics: A Comparison Of Various Braced Vs. Unbraced Techniques, Salina Halliday

Master's Theses and Doctoral Dissertations

High, overuse injury rates to the wrist have been associated with the common mechanism of repetitive hyperextension in weight bearing among gymnasts of all ages. Many gymnasts use wrist supports as prevention; however, literature regarding their ability to reduce injury is not well described. The purpose of this study is to evaluate the effects of Tiger Paw wrist guards and circumferential wrist taping techniques on the kinetics of the wrist during the performance of a back handspring. Vertical Ground Reaction Forces (VGRF) sustained at the hand, time to peak VGRF, and total time of hand contact on the force plate …

Small Changes Now, Big Impact Later: “Non -Attendance” For Appointments In A Patient Centered Medical Home Model--Impact Of A Personalized Appointment Reminder In A Vulnerable Population, Veronica Sanchez-Medina, Sheyla M. Torres, Orlando J. Penaloza Md, Facp

Department of Medicine

No abstract provided.

Research Brief: "A Randomized Controlled Trial Of Supported Employment Among Veterans With Post-Traumatic Stress Disorder", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This brief focuses on some analyses of veterans with PTSD concerning supported employment programs, the Individual Placement and Support (IPS) program, and the evidence-based IPS program. This study's results showed IPS programs to be almost three times more effective than the traditional VRP, and they have a significant impact on employment outcomes for veterans with mental health diagnoses. Suggestions for future research include using a diverse, national sample of veterans to examine the success of the VRP program with different criteria.

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Risk Factors for Childhood Blindness

Reducing Slips In Patient Information Transfers, Melanie R. Francis

USF-LVHN SELECT

No abstract provided.

Download Entire Issue- Jefferson Interprofessional Education And Care Newsletter, Spring, 2013, Volume 4, Issue 1

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Entire Spring 2013, Volume 4, No. 1 JCIPE newsletter

Upcoming Faculty And Staff Development Programs

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Interprofessional Geriatric Education and Practice Institute

Eastern Pennsylvania‐Delaware Geriatric Education Center : Interprofessional Geriatric Practice

Collaborating Across Borders (CAB IV) An American‐Canadian Dialogue on Interprofessional Health Education & Practice

From The Editors, Elizabeth Speakman, Edd, Rn, Anef, Christine A. Arenson, Md

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Welcome to the latest edition of the Jefferson Interprofessional Education and Care Newsletter. In our past newsletter we described a meeting that took place February 2011 that previewed the core competencies presented by IPEC. We are pleased to announce that TJU has adopted four IPE core competencies for Interprofessional Collaborative Practice, they are; Values/Ethics‐ Respect the unique cultures, values, roles/responsibilities and expertise of other health professionals; Roles/ Responsibilities‐ Explain the roles and responsibilities of other health/healthcare providers and how the team works together to provide care; Interprofessional Communication‐ Work to ensure common understanding of information, treatment, and health/healthcare decisions by …

Jeff-Chat Offers Students An Interprofessional Forum To Discuss Experiences, Danielle Elliot, Md, Scott Schmidt, Md, Claire Hoppenot, Md, Maria Hervada-Page, Mss

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Feelings of frustration, loss, and exhaustion are common among healthcare workers. Students placed among new experiences and in a dependent learning role are not shielded from these emotions but often experience them differently from other members of the healthcare team. In addition to the systematic and individual support available through TJUH, for the past year and a half Jeff‐ CHAT (Compassion, Humanism, Altruism, Trust) has provided a forum for students to discuss and reflect on difficult emotions and situations.

Six Sigma Methodology Applied To Immediate Use Sterilization At Thomas Jefferson University Hospital, Beth-Ann Schauer, Mba, Pmp, Ssgb, Lori Szymonowicz, Cpam, Ssgb, Precil Varghese, Pharmd

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Immediate use sterilization, also known as flash sterilization, is an expedited sterilization process used for surgical equipment needed in emergent clinical situations. Immediate use sterilization is a procedure used by Operating Room staff members to sterilize instrumentation on an as needed or just in time basis when instruments needed for a particular case are not immediately available or become contaminated in the course of the case. If instrumentation is not sterilized appropriately, the patient’s safety is possibly put at risk from the potential of surgical site infections. No specific literature data directly correlates immediate use sterilization with surgical site infection. …

The Santa Clara, 2013-04-25, Santa Clara University

The Santa Clara

No abstract provided.

Relationship Of Cellular Topoisomerase Iiα Inhibition To Cytotoxicity And Published Genotoxicity Of Fluoroquinolone Antibiotics In V79 Cells, Gary M. Williams, Klaus D. Brunnemann, Daniel J. Smart, David Molina, Alan M. Jeffrey, Jian-Dong Duan, Niels Krebsfaenger, Andreas Kampkoetter, Gabriele Schmuck

NYMC Faculty Publications

Fluoroquinolone (FQ) antibiotics are bacteriocidal through inhibition of the bacterial gyrase and at sufficient concentrations in vitro, they can inhibit the homologous eukaryotic topoisomerase (TOPO) II enzyme. FQ exert a variety of genotoxic effects in mammalian systems through mechanisms not yet established, but which are postulated to involve inhibition of TOPO II enzymes. To assess the relationship of inhibition of cell nuclear TOPO II to cytotoxicity and reported genotoxicity, two FQ, clinafloxacin (CLFX) and lomefloxacin (LOFX), having available genotoxicity data showing substantial differences with CLFX being more potent than LOFX, were selected for study. The relative inhibitory activities of these …

The Role Of Nurses In Pediatric Pain Assessment And Interventions, Katie Pfannenstein

Honors Capstones

Capstone submitted as a graduation requirement for the BSU Honors Program.

2013 - The Eighteenth Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Eighteenth Annual Symposium of Student Scholars, held on April 25, 2013. Includes abstracts from the presentations and posters.