Medicine and Health Sciences Commons^™

Lessons Learned From Training Of Promotores De Salud For Obesity And Diabetes Prevention, Erica T. Sosa, Lesli Biediger-Friedman, Zenong Yin

Journal of Health Disparities Research and Practice

Background: Promotores de Salud are impactful in reducing health disparities for Hispanic communities. The purpose of this paper is to present the training process and fidelity of study protocol implementation using a promotora model for community-based diabetes prevention.

Methods: Five Hispanic bilingual promotores were recruited from a Community Health Worker program and received intensive 30-hour promotora training on how to recruit participants, lead group sessions, and support participants making behavior changes. Evaluation of the training included a survey and focus group to assess promotores’ feedback, a post-training knowledge test to assess knowledge acquired during the training and an observational assessment …

Glycosylate Derivatives Of Mithramycin, Method Of Preparation And Uses Thereof, Jürgen Rohr, Irfan Baig, Jose Antonio Salas Fernandez, Alfredo Fernandez Brana, Maria Perez Solares

Pharmaceutical Sciences Faculty Patents

The present invention provides compounds characterized by the formula (I), where each of the substituent radicals is described in the specification. The invention also describes the use of said compounds in the treatment of various diseases, including: cancer or tumoral processes in general, Paget's disease, hypercalcaemia, hypercalciuria and neurological diseases (inter alia, Parkinson's, Alzheimer's, Huntington's).

A Perspective On Multiple Waves Of Influenza Pandemics, Anna Mummert, Howard Weiss, Li-Ping Long, José M. Amigó, Xiu-Feng Wan

CVM Publications

BACKGROUND: A striking characteristic of the past four influenza pandemic outbreaks in the United States has been the multiple waves of infections. However, the mechanisms responsible for the multiple waves of influenza or other acute infectious diseases are uncertain. Understanding these mechanisms could provide knowledge for health authorities to develop and implement prevention and control strategies. MATERIALS AND METHODS: We exhibit five distinct mechanisms, each of which can generate two waves of infections for an acute infectious disease. The first two mechanisms capture changes in virus transmissibility and behavioral changes. The third mechanism involves population heterogeneity (e.g., demography, geography), where …

Divergent Protein Motifs Direct Ef-P Mediated Translational Regulation In Salmonella And Escherichia Coli, Steven J. Hersch, Mengchi Wang, S. Betty Zou, Kyung-Mee Moon, Leonard J. Foster, Michael Ibba, William Wiley Navarre

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Elongation factor P (EF-P) is a universally conserved bacterial translation factor homologous to eukaryotic/archaeal initiation factor 5A. In Salmonella, deletion of the efp gene results in pleiotropic phenotypes, including increased susceptibility to numerous cellular stressors. Only a limited number of proteins are affected by the loss of EF-P, and it has recently been determined that EF-P plays a critical role in rescuing ribosomes stalled at PPP and PPG peptide sequences. Here we present an unbiased in vivo investigation of the specific targets of EF-P by employing stable isotope labeling of amino acids in cell culture (SILAC) to compare the …

Design, Synthesis And Evaluation Of Antimicrobial Activity Of N-Terminal Modified Leucocin A Analogues, Krishna Chaitanya Bodapati, Rania Soudy, Hashem Etayash, Michael Stiles, Kamaljit Kaur

Pharmacy Faculty Articles and Research

Class IIa bacteriocins are potent antimicrobial peptides produced by lactic acid bacteria to destroy competing microorganisms. The N-terminal domain of these peptides consists of a conserved YGNGV sequence and a disulphide bond. The YGNGV motif is essential for activity, whereas, the two cysteines involved in the disulphide bond can be replaced with hydrophobic residues. The C-terminal region has variable sequences, and folds into a conserved amphipathic α-helical structure. To elucidate the structure–activity relationship in the N-terminal domain of these peptides, three analogues (1–3) of a class IIa bacteriocin, Leucocin A (LeuA), were designed and synthesized by …

Attire And Appearance Of Orthodontists: A Survey Of Parent Preferences, Gillian Kelly

Theses and Dissertations

The objective of this study was to evaluate parents’ preferences of the appearance and attire of orthodontists. Six subjects were asked to pose for photographs wearing various combinations of attire (casual, scrubs, white coat, formal), hairstyle and nametag. Survey participants were presented with choice sets and asked to select the most and least preferred provider photographs. A total of 77 parents of orthodontic patients participated in the computer-based survey. The results indicated that there were significant differences due to provider sex (P = 0.0013), provider age (P < .0001), dress (P < .0001), nametag (P = 0.0065) and hair (P < .0001). The most preferred providers were the younger female and the older male. Formal attire or scrubs was the most preferred style of dress. There was also a preference for the use of a nametag and for the provider to have his/her hair in a controlled style.

To Re-Excise Or Not To Re-Excise: Positive Margins After Excision Of Non-Melanoma Skin Cancers, Ramon Garza, Iii Md, Courtney Edwards Md, Bharat Ranganath Md, Nathan F. Miller Bs, Joshua M. Adkinson Md, Kirsten S. Bellucci Md, Robert X. Murphy Jr, Md, Ms

Department of Surgery

No abstract provided.

Malnutrition And Diseases Affecting The Children Of Uganda, Crystal Brooke Baldwin

Senior Honors Theses

Every day there are children in underdeveloped countries, such as Uganda, who are struggling to survive on minimal food, money, and other resources. These children do not have the opportunity to enjoy the benefits of a normal childhood because their main focus is on survival. Many of these children will die because of preventable disease and starvation that have resulted from the endless cycle of poverty and lack of education. Those who are lucky enough to survive must fight a daily battle to find the nutrients they need and to combat the diseases they may acquire. It is heartbreaking to …

Nurses’ Perspectives On Neonatal Massage Therapy In The Neonatal Intensive Care Unit, Kayla R. Hanson

Senior Honors Theses

Research in neonatal massage therapy has shown many possible benefits to the baby and family. Though there has been a growing trend towards family-centered care, along with a substantial and growing body of research, the practice of neonatal massage therapy is not routine in most NICUs. This study was conducted to evaluate neonatal intensive care nurses’ perspectives and attitudes towards neonatal massage therapy before and after evidence-based education. Willingness to discuss benefits of neonatal massage therapy significantly increased after education on neonatal massage therapy. The findings suggest that with proper training on the techniques and safety monitoring of massage therapy, …

Développement D'Une Procédure De Mesure De L'Efficacité Des Filtres D'Appareils De Protection Respiratoire N95 Contre Les Nanoparticules, Fariborz Haghighat, Ali Bahloul, Jaime Lara, Reza Mostofi, Alireza Mahdavi

Rapports de recherche scientifique

Les risques pour la santé et la sécurité des travailleurs exposés à l’inhalation de nanoparticules (NP) soulèvent de plus en plus d’inquiétudes. Parmi les sources d’émission de nanoparticules en milieu de travail figurent les effluents et les émanations de divers procédés, tels l’ablation et le fraisage laser. Les nanoparticules ont des propriétés potentiellement toxiques, à savoir une surface totale, une concentration en nombre et une réactivité surfacique élevées. Il a été démontré que l’inhalation – la voie d’exposition la plus courante aux nanoparticules – a des effets nocifs sur les fonctions pulmonaires, et que les particules déposées dans les poumons …

Non-Pharmacologic Interventions For Long-Term Chronic Insomnia, Bo Mi You

Nursing Masters

Purpose: To systematically review, analyze and synthesize empirical evidence that has been published regarding the effectiveness of non-pharmacological management for patients with chronic insomnia.

Acute Pharmacological Treatment Given To Older Adults With Acute Myocardial Infarction: A Nationwide Emergency Department Study, 1992-2010, Maryam S. Alowayesh

Theses and Dissertations

OBJECTIVES: To determine the pattern and predictors of use of antiplatelet agents and beta-blockers given in the emergency department (ED) to older adults with acute myocardial infarction (AMI) and its effects on in-hospital mortality and length of hospital stay (LOS) and to determine the effect of computerized ED guideline reminders on their utilization. METHODS: A cross-sectional study using the National Hospital Ambulatory Medical Care Survey (NHAMCS) ED data for years 1992 to 2010 was conducted. Patients were included if they had an admission diagnosis of AMI (ICD-9-CM code 410.xx) and were ≥55 years. Survey logistic regression was used to examine …

Synthesis Of A Cobalt Complex Of A Sulfonated Binucleating Schiff Base Ligand, Jieun Emily Hwang

Journal of Interdisciplinary Undergraduate Research

Current synthesis of cobalt (II) complexes of sulfonated binucleating Schiff base ligands requires the reaction be run under nitrogen.¹ This research introduces a novel process in which the complex can be prepared in open air. The cobalt (II) complexes are prepared with synthesized 5-sulfosalicylaldehyde, and then analyzed by IR and UV-Vis spectrophotometry.

Vaccination With Human Hookworm Vaccine "Necator Americanus Aspartic Protease-1 M74" Generates Neutralizing Antibodies And A Potent Immune Response In Balb/C Mice, Amar R. Jariwala, Xi Chen, Mark S. Pearson, Brian Keegan, Jill B. Brelsford, Jordan L. Plieskatt, Alex Loukas, Bin Zhan, Peter J. Hotez, Jeffrey M. Bethony

Microbiology, Immunology, and Tropical Medicine Posters and Presentations

Backgound: Human Hookworm Infection, a neglected tropical disease infects more than 600 million people around the world. Hookworms ingest hemoglobin containing erythrocytes and Necator americanus Aspartic Protease-1 wild type (Na-APR-1wt) a hemoglobinase cleaves hemoglobin to form Heme and Globin. Globin is further digested by other gut enzymes and the nutritional end products are absorbed by the hookworm’s gut wall. Also, Heme which is toxic to hookworm is detoxified by the Necator americanus Glutathione Transferase-1 (Na-GST-1) a detoxification enzyme secreted by the gut of the hookworm. Necator americanus Aspartic Protease-1 M74 (Na-APR-1 M74) is the …

Global Budgets, Payment Reform And Single Payer: Understanding Vemont's Health Reform, Trish Riley

Population Health & Health Policy

The Muskie School of Public Service hosted two health policy colloquia this April to promote informed discussion throughout the state regarding MaineCare coverage options under the ACA and the implications of Vermont’s move toward a single-payer system.The series, sponsored by the Muskie School Board of Visitors, offers community conversations in which experts from various disciplines and perspectives inform and engage the broader public to explore and debate critical policy issues. On April 22, community and sector leaders joined for Global Budgets, Payment Reform, and Single Payer: Understanding Vermont's Health Reform. Participants discussed Vermont's recent movie toward single payer health …

What's Happening: April 22, 2013, Maine Medical Center

What's Happening

No abstract provided.

Healthy Skin Is In: Effects Of A Multifaceted Sun Safety Program For Adolescents, Lindsay A. Munden

Evidence-Based Practice Project Reports

Skin cancer is a common, potentially life threatening disease notably on the rise among young Americans. A substantial portion of lifetime exposure to ultraviolet (UV) radiation, the greatest modifiable risk factor for skin cancer development, occurs during childhood and adolescence. Schools infrequently integrate sun safety education into the classroom and many lack essential sun safety policies. The purpose of this EBP project was to implement a multifaceted educational intervention providing middle school students with the knowledge behavioral skills needed to minimize the risk of developing skin cancer. The Health Belief Model and ACE Star Model of evidence-based practice guided this …

The Pluripotency Proposition: A Biological And Ethical Case For The Utilization Of Hipscs In Place Of Hescs, Drew Dickson

Senior Honors Theses

Human embryonic stem cell (hESC) research has spurred ethical controversy ever since it became feasible in 1998. The reason for this is due to the fact that hESC research requires the destruction of a human embryo, thereby causing the cessation of life for that developing human. Despite this unavoidable consequence, many advocates of hESC research hold to the belief that the embryo is not actually a human person, and therefore deem the destruction of the embryo as justifiable. Many advocates of hESC research also have pointed to the unprecedented medical potential of hESCs to argue in favor of their case. …

Complementary And Alternative Medicine: The History, Current Prevalence, And Future Projections, Melissa J. De Nijs

Senior Honors Theses

Complementary and alternative medicine (CAM) has been used for centuries. Common methods include chiropractic, diet, yoga, and prayer. Though some methods have proven more successful than others, many have insufficient data to support claims of effectiveness.

A survey of medical professionals involving twenty-seven CAM methods was conducted in order to evaluate modern perceptions of complementary and alternative medicine. They were asked their experience with CAM, their personal opinion regarding its effectiveness, and how likely they would be to recommend a CAM treatment to a patient.

It has been hypothesized that more CAM treatments will be utilized in the future. This …

Providing Holistic And Spiritual Nursing Care, Jessika D. Gore

Senior Honors Theses

Holistic nursing is care of the whole person, which addresses physical, mental, emotional, spiritual, and relational aspects of health. Historically, nursing has always integrated these aspects into providing care. Nursing developed out of religious orders and was predominantly a way to serve God by serving the poor and the sick. Florence Nightingale believed that nursing was her calling from God and her faith and spirituality influenced every aspect of her care. Nurses today are often fearful of addressing the spiritual needs of their patients, despite research that demonstrates the importance of providing care in these areas. Nurses can use interventions …

Body Image And Disordered Eating Patterns In African-American College Women, Amazing Grace L. Danso

Senior Honors Theses

Currently, increasing scholarly attention is being given to eating disorders such as anorexia nervosa, bulimia, and binge eating. A bulk of the research on the issue has focused on Caucasian women. As a result, the body of research may be limited in its generalization to other racial and ethnic groups. This study, therefore, sought to study disordered eating among African-American college women. Two models based on research questions were tested. The first focused on how body mass index (BMI) impacted disordered eating, while the second focused on how the difference between perceived actual and ideal body image impacted disordered eating. …

The Influence Of Active Reminders On Oral Hygiene Compliance In Orthodontic Patients, Matthew Eppright

Theses and Dissertations

Text message reminders have proven effective for positive behavioral changes in medicine, but their influence on oral hygiene compliance has never been tested. This study aimed to determine if text message reminders about oral hygiene have an influence on the level of compliance. In this prospective randomized controlled clinical trial, 42 orthodontic patients were assigned to a text message or control group. Parents of patients assigned to the text message group received a reminder text message one weekday each week. Oral hygiene compliance was measured using bleeding index, modified gingival index, plaque index, and visual examination of white spot lesion …

The Role Of Alginate In The Inhibition Of Macrophage Phagocytosis Of Mucoid Pseudomonas Aeruginosa, Warren Rowe Iii

Theses and Dissertations

During colonization of the cystic fibrosis airway Pseudomonas aeruginosa converts from non-mucoid to a mucoid phenotype, characterized by the production of the exopolysaccharide alginate. Alginate production has been shown to enhance survival by promoting biofilm formation, evading complement killing, and resisting phagocytosis. The mechanism by which alginate protects P. aeruginosa from phagocytosis is unclear. To investigate the role of alginate in the inhibition of phagocytosis, a human monocytic cell line (THP-1) and a murine alveolar macrophage cell line (MH-S) were used to determine the effects of alginate on macrophage binding, signaling, and phagocytosis. Phagocytosis assays using the mucoid cystic fibrosis …

Medical School Watercooler Newsletter - April 21, 2013, Lindsey Lyle

Watercooler Newsletter

This is the April 21, 2013 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler

Content Includes

• May 2nd DSS to Feature Dr. David Walker
• COM Class of 2013 to Host Skit Night

• Biotech Company Affiliated with USA College of Medicine Advances in Alabama Launchpad Competition

• USA Autism Interest Group to Host Autism Grand Rounds

• Dr. Marc E. Mitchell to Present Frazer/Leigh Memorial Lecture

Shared Neural Substrates Of Emotionally Enhanced Perceptual And Mnemonic Vividness, Rebecca M. Todd, Taylor W. Schmitz, Josh Susskind, Adam K. Anderson

Brain and Mind Institute Researchers' Publications

It is well known that emotionally salient events are remembered more vividly than mundane ones. Our recent research has demonstrated that such memory vividness is due in part to the subjective experience of emotional events as more perceptually vivid, an effect we call emotion-enhanced vividness, or EEV. The present study built on previously reported research in which fMRI data were collected while participants rated relative levels of visual noise overlaid on emotionally salient and neutral images. Ratings of greater EEV were associated with greater activation in the amygdala, visual cortex, and posterior insula. In the present study, we measured BOLD …

The Development Of A Public Optometry System In Mozambique: A Cost Benefit Analysis, Stephen Thompson, James Loughman

Articles

The economic burden of uncorrected refractive error (URE) is thought to be high in Mozambique, largely as a consequence of the lack of resources and systems to tackle this largely avoidable problem. The Mozambique Eyecare Project (MEP) has established the first optometry training and human resource deployment initiative to address the burden of URE in Lusophone Africa. The nature of the MEP programme provides the opportunity to determine, using Cost Benefit Analysis (CBA), whether investing in the establishment and delivery of a comprehensive system for optometry human resource development and public sector deployment is economically justifiable for Lusophone Africa.

Mccormack, Joseph Nathaniel, 1847-1922 (Sc 1005), Manuscripts & Folklife Archives

Manuscript Collection Finding Aids

Finding aid and full-text scan (Click on "Additional Files" below) for Manuscripts Small Collection 1005. Letter addressed to “Dear Doctor”, sent by secretary Joseph Nathaniel McCormack of the Kentucky State Board of Health, Bowling Green, Kentucky, extolling the merit of the Rosenow-Mayo vaccine for the prevention of influenza and pneumonia. Dr. Lillian South is noted as the one in charge of the vaccine distribution.

Considerations In The Design Of An Eye Health Programme For Nampula, Mozambique, Aoife Phelan, Lisa O'Donoghue, Kovin Naidoo, Kathryn Saunders, James Loughman

Conference Papers

Introduction/Purpose:

There are almost twelve million children (<18 >years) in Mozambique with minimal access to eye care. [1] Annual screening of school children by teachers for uncorrected refractive error is one of the most cost effective health interventions in Sub Saharan Africa.[2] The International Agency for the Prevention of Blindness (IAPB) has recommended that child eye health interventions be incorporated into National School Health Initiatives.[3]

In view of the IAPB position this presentation sets out to identify and discuss the main considerations in the design of a child eye health strategy, for the province of Nampula, Mozambique, which aligns itself …

On The Role Of Abnormal Dl(Co) In Ex-Smokers Without Airflow Limitation: Symptoms, Exercise Capacity And Hyperpolarised Helium-3 Mri, Miranda Kirby, Amir Owrangi, Sarah Svenningsen, Andrew Wheatley, Harvey O Coxson, Nigel A M Paterson, David G Mccormack, Grace Parraga

Medical Biophysics Publications

BACKGROUND: The functional effects of abnormal diffusing capacity for carbon monoxide (DLCO) in ex-smokers without chronic obstructive pulmonary disease (COPD) are not well understood.

OBJECTIVE: We aimed to evaluate and compare well established clinical, physiological and emerging imaging measurements in ex-smokers with normal spirometry and abnormal DLCO with a group of ex-smokers with normal spirometry and DLCO and ex-smokers with Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage I COPD.

METHODS: We enrolled 38 ex-smokers and 15 subjects with stage I COPD who underwent spirometry, plethysmography, St George's Respiratory Questionnaire (SGRQ), 6 min Walk Test (6MWT), x-ray CT and …

Considerations In The Design Of An Eye Health Programme For Nampula, Mozambique, Aoife Phelan, Lisa O'Donoghue, Kovin Naidoo, Kathryn Saunders, James Loughman

Other

Introduction/Purpose:

There are almost twelve million children (years) in Mozambique with minimal access to eye care. [1] Annual screening of school children by teachers for uncorrected refractive error is one of the most cost effective health interventions in Sub Saharan Africa.[2] The International Agency for the Prevention of Blindness (IAPB) has recommended that child eye health interventions be incorporated into National School Health Initiatives.[3]

In view of the IAPB position this presentation sets out to identify and discuss the main considerations in the design of a child eye health strategy, for the province of Nampula, Mozambique, which aligns itself with …