Medicine and Health Sciences Commons^™

A Matter Of Choice: Perceptions Of Personal Mastery And Control After Giving Birth, Melissa A. Dalton-Richardson, Dr. Lynn Callister

Journal of Undergraduate Research

Within recent years, there has been a steady increase of births attended by midwives in the United States. The reemergence of midwives to the medical scene provides pregnant women with alternative methods of birth. In order to provide women with the most information possible about these two options of maternity care, there has been a good deal research done in the area of comparisons between obstetricians and certified nurse-midwives (CNM). Thus far, the research has done much in demarcating the differences in treatment and satisfaction of pregnant women. My research question took the next step in the research comparison. I …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Barber-Administered Health Education

Community Health News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Barber-Administered Health Education

Research Brief: "Predictors Of Psychiatric Disorders In Combat Veterans", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This brief is about the predictors of mental health diagnoses within a sample of Marines who experienced combat in Iraq and Afghanistan. In policy and practice, support networks should be implemented for servicemembers to share with their peers, clinicians should give female servicemembers and others who have a higher likelihood of developing a mental health disorder after combat information on how to prevent certain psychiatric disorders, and families should know the signs of psychiatric disorders to help servicemembers in their re-adjustment period after deployment. Military branches and policymakers could improve counseling for servicemembers returning from combat and encourage servicemembers to …

An Evidence-Based Intervention To Improve Vaccination Rates For Seasonal Influenza Among Registered Nurses, Debra A. Maitre

Regis University Student Publications (comprehensive collection)

Executive Summary An Evidence-Based Intervention to Improve Vaccination Rates for Seasonal Influenza Among Registered Nurses Problem Seasonal influenza continues to cause the hospitalizations and deaths of tens of thousands every year in the U.S. (National Foundation for Infectious Diseases, 2008). Vaccination of healthcare workers for influenza has been recommended for more than 30 years (Willis & Wortley, 2007) and reports of transmission of influenza by registered nurses (RNs) to patients are well documented. In spite of these facts, RN vaccination rates remain below the recommended target of 90% (U.S. Department of Health and Human Services, 2012). The evidence suggests that …

Intracellular Reprogramming Of Expression, Glycosylation, And Function Of A Plant-Derived Antiviral Therapeutic Monoclonal Antibody., Jeong-Hwan Lee, Da-Young Park, Kyung-Jin Lee, Young-Kwan Kim, Yang-Kang So, Jae-Sung Ryu, Seung-Han Oh, Yeon-Soo Han, Kinarm Ko, Young-Kug Choo, Sung-Joo Park, Robert Brodzik, Kyoung-Ki Lee, Doo-Byoung Oh, Kyung-A Hwang, Hilary Koprowski, Yong Seong Lee, Kisung Ko

Department of Cancer Biology Faculty Papers

Plant genetic engineering, which has led to the production of plant-derived monoclonal antibodies (mAb(P)s), provides a safe and economically effective alternative to conventional antibody expression methods. In this study, the expression levels and biological properties of the anti-rabies virus mAb(P) SO57 with or without an endoplasmic reticulum (ER)-retention peptide signal (Lys-Asp-Glu-Leu; KDEL) in transgenic tobacco plants (Nicotiana tabacum) were analyzed. The expression levels of mAb(P) SO57 with KDEL (mAb(P)K) were significantly higher than those of mAb(P) SO57 without KDEL (mAb(P)) regardless of the transcription level. The Fc domains of both purified mAb(P) and mAb(P)K and hybridoma-derived mAb (mAb(H)) had similar …

Oncogenes And Inflammation Rewire Host Energy Metabolism In The Tumor Microenvironment: Ras And Nfκb Target Stromal Mct4., Ubaldo E. Martinez-Outshoorn, Md, Joseph Curry, Md, Ying-Hui Ko, Md, Zhao Lin, Md, Madalina Tuluc, Md, David Cognetti, Md, Ruth Birbe, Md, Edmund A. Pribitkin, Md, Alessandro Bombonati, Richard Pestell, Md, Anthony Howell, Federica Sotgia, Michael P. Lisanti, Md

Kimmel Cancer Center Faculty Papers

Here, we developed a model system to evaluate the metabolic effects of oncogene(s) on the host microenvironment. A matched set of "normal" and oncogenically transformed epithelial cell lines were co-cultured with human fibroblasts, to determine the "bystander" effects of oncogenes on stromal cells. ROS production and glucose uptake were measured by FACS analysis. In addition, expression of a panel of metabolic protein biomarkers (Caveolin-1, MCT1, and MCT4) was analyzed in parallel. Interestingly, oncogene activation in cancer cells was sufficient to induce the metabolic reprogramming of cancer-associated fibroblasts toward glycolysis, via oxidative stress. Evidence for "metabolic symbiosis" between oxidative cancer cells …

Navigating Veterans With An Abnormal Prostate Cancer Screening Test: A Quasi-Experimental Study, Melissa A. Simon, Narissa J. Nonzee, June M. Mckoy, Dachao Liu, Thanh Ha Luu, Peter Byer, Elizabeth A. Eklund, Elizabeth A. Richey

Dartmouth Scholarship

Prostate cancer disproportionately affects low-income and minority men. This study evaluates the impact of a patient navigation intervention on timeliness of diagnostic resolution and treatment initiation among veterans with an abnormal prostate cancer screen.MethodsParticipants were enrolled between 2006 and 2010. The intervention involved a social worker and lay health worker navigation team that assisted patients in overcoming barriers to care. For navigated (n = 245) versus control (n = 245) participants, we evaluated rates of diagnostic resolution and treatment and adjusted for race, age, and Gleason score.

Exploring Online Community Among Rural Medical Education Students: A Case Study, Ryan Tyler Palmer

Dissertations and Theses

There is a severe shortage of rural physicians in America. One reason physicians choose not to practice, or persist in practice, in rural areas is due to a lack of professional community, i.e., community of practice (CoP). Online, "virtual" CoPs, enabled by now common Internet communication technology can help give rural physicians the CoP experience they traditionally have lacked, despite their remote practice locations. Therefore, it is important for rural medical education programs to provide technological experiences that give students the skills needed to create virtual CoPs in future rural practice contexts.

The Oregon Rural Scholars Program (ORSP) provides such …

Exploring Tissue Engineering: Vitamin D3 Influences On The Proliferation And Differentiation Of An Engineered Osteoblast Precursor Cell Line During Early Bone Tissue Development, Shelley S. Mason

Dissertations and Theses

Most of the load-bearing demand placed on the human body is transduced by skeletal tissue, and the capacity of the skeleton to articulate in various opposing directions is essential for body movement and locomotion. Consequently, cartilage and bone defects due to trauma, disease, and developmental abnormalities result in disabling pain and immobility for millions of people worldwide. A novel way of promoting cartilage and bone regeneration is through the incorporation of either primary cells or multipotent progenitor cells in a three-dimensional (3D) biomaterial scaffold, and/or the addition of exogenous growth and differentiation factors. The first part of this study reports …

Extrauterine Listeriosis In The Gravid Mouse Influences Embryonic Growth And Development, M. M. Suyemoto, T. S. Hamrick, P. A. Spears, J. R. Horton, I. M. Washington, E. A. Havell, L. B. Borst, P. E. Orndorff

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.

Immunopathology Of Cd4+ T Cell-Mediated Autoimmune Responses To Central Nervous System Antigens: Role Of Il-16, Harley Y. Tse, Dusanka S. Skundric, William W. Cruikshank, Paul C. Montgomery, Robert P. Lisak

Neurology Faculty Publications

Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating and degenerative disease of the central nervous system (CNS). While etiology of the disease remains unknown, genetic susceptibility and autoimmune mechanisms in the initiation and progression of the disease have been strongly suggested. Experimental autoimmune encephalomyelitis (EAE) is commonly used to study immune regulation of MS. Infiltration by CD4⁺ T cells, through blood-brain barrier (BBB), precedes the onset and relapses of MS. CNS migration and homing patterns of T cells are tightly synchronized by astrocyte and microglia derived cytokines and chemokines. Autoimmune, CNS antigenreactive, infiltrating T cells produce and locally release …

Postpartum Depression And Help-Seeking Behaviors In Immigrant Hispanic Women, Glauco Souza, Dr. Lynn Clark Callister

Journal of Undergraduate Research

The purpose of this qualitative descriptive study was to describe the experience of having symptoms of postpartum depression (PPD) and identify help seeking behaviors in immigrant Hispanic women.

The Experiences Of Siblings Of Children With Autism, Elizabeth Ward, Dr. Barbara Mandleco

Journal of Undergraduate Research

The social and behavioral issues of autism are very unique and have a deep impact on families, particularly siblings, as they learn to cope and live with a child with autism (CWA). However, there is limited information in the literature relative to the experience of the sibling, and the information that does exist is often conflicting. The research shows that siblings of CWA experience stress, frightening behavior, and violence in the home (Benderix & Sivberg, 2007). Furthermore, some researchers found that siblings demonstrated less intimacy in sibling relationships, and were negatively affected socially and emotionally (Hastings, 2003; Kaminsky & Dewey, …

Information From The Experts Themselves: What Children With Diabetes Need And Desire, Corinne Jackman, Dr. Barbara Mandleco

Journal of Undergraduate Research

The purposes of this research are to 1) discover perceptions children/adolescents with diabetes have about their lives/illness and 2) develop appropriate interventions based on these perceptions. A number of youth diagnosed with type 1 diabetes face difficult challenges concerning their care and causing great stress on their family. Asking youth about their perceptions of living with type 1 diabetes can be useful in developing interventions that are exactly what the youth need/desire as they cope with their chronic illness. Hopefully, adjustment to the illness will be smoother and the family unit helped as the needed interventions are provided.

Measuring Cultural Competence In Nursing: A Qualitative Comparison Of Education And Workforce Measures, Robin Ellis, Dr. Erin Maughan

Journal of Undergraduate Research

The most recently published United States census indicates that nearly one fourth of the United States population is non-Caucasian (“Race and Ethnic Distribution,” 2001). Unlike the general population, nearly 90% of registered nurses identify themselves as primary Caucasian. Consequently, cultural awareness in health care has become an imperative issue.

Perceptions Of Single Parents Raising A Child With Disabilities: A Pilot Study, Dr. Barbara Mandleco, Danielle Nyholm

Journal of Undergraduate Research

Parents raising a child with disabilities (CWD) are subject to a unique experience that is often accompanied by many challenges not experienced by a parent raising normally developing children. The experience requires extensive time and money, and the parents endure many stressors resulting in exhaustion (Green, 2007). In addition, Kelso, French, and Fernandez (2005) found stressors for two-parent families of a CWD include the process of diagnosis, treatment decisions, the ability to function spontaneously as a family, schooling for their child, and lack of professional attention to their CWD. If two-parent families experience these difficulties, single-parent families will likely have …

A Gene-Positive Dad’S Reflections On Huntington’S Disease, Parenthood, And The Fragility Of Life, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Parental Perceptions: Religiosity And Depression In Families Raising A Child With Diabetes, Caitlin Herrmann Peterson, Dr. Barbara Mandleco

Journal of Undergraduate Research

Parents raising children with disabilities (CWD) experience a number of situations and stresses parents not raising a CWD experience. How families adapt to the situation of raising a CWD may be related to a number of variables including the parent’s religiosity and the depression level of the parents. Clearly, religion serves as an important resource to families; however, it may also act as a resource for families who are raising a CWD. In fact, qualitative and empirical studies alike show religious practices and spiritual beliefs predict relational outcomes (Richards & Bergin, 1997). There is minimal literature examining differences in religiosity …

Relationship Between Grief And Sleep Among Grief Group Members, Diana Snyder, Beth Cole

Journal of Undergraduate Research

Grief and bereavement can be defined as experiences created by responses to the loss of a family member or close friend. Such distressing experiences can be amplified by sleep dysfunction because of the devastating effects poor sleep quality has in healthy functioning. In a study done by Richardson, Lund, Caserta, Dudley, and Obray (2003), it was noted that 50 % of a group of 192 bereaved widows and widowers reported sleep disturbance within the first few months after the death of a spouse. Sleep disturbances have been highly correlated with problems such as depression, emotional lability, anger, loss of control, …

Nursing Students’ Perceptions Of Learning Outcomes Throughout Simulation Experiences, Christina Hunter, Dr. Patricia Ravert

Journal of Undergraduate Research

Identified learning outcomes when using high-fidelity simulators in a nursing lab are 1) improving communication, 2) increasing psychomotor skills, 3) understanding classroom material, 4) developing critical thinking, and 5) facilitating teamwork (Bambini, Washburn, & Perkins, 2009; McGaghie, Issenberg, Petrusa, & Scalese, 2006). Nursing students in each semester develop different learning outcomes. Communication, improving nursing skills, and developing critical thinking are outcomes of simulation for novice students (Bambini et al.). However, data is limited on outcomes of simulation for other levels of nursing students. The purpose of this study is to determine students’ perceptions regarding learning outcomes and their development throughout …

The Experiences Of Siblings Living With A Child With Type 1 Diabetes Mellitus, Mckenzie Miller, Dr. Barbara Mandleco

Journal of Undergraduate Research

Up to 40% of children in the United States require health related services above those needed by other children due to a chronic condition or illness, and as the majority of these children live at home, their presence greatly affects family members living with them (Mandleco, 2009). Although several chronic illnesses are seen in children, type 1 diabetes is one of the most common and the number of new cases is increasing each year (Lowes, Gregory, & Lyne, 2005). With the increasing frequency of this disease, it is critical that health-care providers know the effects it has on the diagnosed …

The Effects Of Prenatal Education On Maternal Perceptions Of Labor Experience, Christie Sue Henrichsen, Cassidy Tomao

Journal of Undergraduate Research

This qualitative descriptive study examined the perceptions of the birth experience for primaparous women who had received prenatal education classes (PNEC) compared with those who did not. The researchers surveys 20 women who had received PNEC and 20 who had not. Women were surveyed on the postpartum unit within 72 hours of giving birth and briefly interviewed about their experience.

Disseminating Evidence: Global Health And Nursing Column, Christina Bohn, Dr. Lynn Clark Callister

Journal of Undergraduate Research

The purpose of this project was to (1) disseminate evidence about global initiatives and individual nurses who are making a difference in the health of women and children worldwide, and (2) identify how nurses can become involved in global efforts. This evidence is published in MCN: The American Journal of Maternal Child Nursing and was presented at the Brigham Young University College of Nursing annual research conference on October 25, 2010.

Aryl Hydrocarbon Receptor Ligands Inhibit Igf-Ii And Adipokine Stimulated Breast Cancer Cell Proliferation, Travis B. Salisbury, Gary Z. Morris, Justin K. Tomblin, Ateeq R. Chaudhry, Carla Cook, Nalini Santanam

Pharmaceutical Science and Research

Obesity increases human cancer risk and the risk for cancer recurrence. Adipocytes secrete paracrine factors termed adipokines that stimulate signaling in cancer cells that induce proliferation. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that plays roles in tumorigenesis, is regulated by exogenous lipophilic chemicals, and has been explored as a therapeutic target for cancer therapy. Whether exogenous AHR ligands modulate adipokine stimulated breast cancer cell proliferation has not been investigated. We provide evidence that adipocytes secrete insulin-like growth factor 2 (IGF-2) at levels that stimulate the proliferation of human estrogen receptor (ER) positive breast cancer cells. Using …

August 13, 2013, Communication Disorders & Sciences

Faculty Meeting Minutes & Agendas

The August 13, 2013 "Welcome Back" faculty meeting.

Deficits In Retrospective And Prospective Components Underlying Prospective Memory Tasks In Amnestic Mild Cognitive Impairment, Ting Zhou, Lucas S. Broster, Yang Jiang, Feng Bao, Huali Wang, Juan Li

Behavioral Science Faculty Publications

OBJECTIVES: By use of purer indices of PM and RM components than previous studies and adoption of three PM task types, the present study aimed to investigate the deficits of these two components underlying global impairment at a PM task in individuals with amnestic mild cognitive impairment (aMCI).

METHODS: Nineteen aMCI patients and 22 normal controls were examined on event-, time- and activity-based PM tasks. Separate scores were obtained for initiation of intentions (i.e. PM component) and for the content of the intentions (i.e. RM component).

RESULTS: Individuals with aMCI achieved lower PM component (but not RM component) scores than …

What Attributes Of Patients Affect Their Involvement In Safety? A Key Opinion Leaders’ Perspective, Stephen Buetow, Rachel E. Davis, Kathleen Callaghan, Susan Dovey

Faculty Publications

OBJECTIVE: Little is known about which attributes the patients need when they wish to maximise their capability to partner safely in healthcare. We aimed to identify these attributes from the perspective of key opinion leaders. DESIGN: Delphi study involving indirect group interaction through a structured two-round survey. SETTING: International electronic survey. PARTICIPANTS: 11 (65%) of the 17 invited internationally recognised experts on patient safety completed the study. OUTCOME MEASURES: 50 patient attributes were rated by the Delphi panel for their ability to contribute maximally to safe health care. RESULTS: The panellists agreed that 13 attributes are important for patients who …

Causes, Consequences, And Treatment Of Osteoporosis In Men, Jameela Banu

Health & Biomedical Sciences Faculty Publications

Men undergo gradual bone loss with aging, resulting in fragile bones. It is estimated that one in five men will suffer an osteoporotic fracture during their lifetime. The prognosis for men after a hip fracture is very grim. A major cause is reduction of free testosterone. Many other factors result in secondary osteoporosis, including treatment for other diseases such as cancer and diabetes. Patients should be screened not only for bone density but also assessed for their nutritional status, physical activity, and drug intake. Therapy should be chosen based on the type of osteoporosis. Available therapies include testosterone replacement, bisphosphonates, …

Diffusion Of Innovation Across A National Local Health Department Network: A Simulation Approach To Policy Development Using Agent-Based Modeling, Mark Orr, Jacqueline Merrill

Frontiers in Public Health Services and Systems Research

The network that local health officials use to communicate about professional issues is sparsely connected, which may limit the spread of innovative practices. We used agent-based simulation modeling to find out if a policy to promote more connections improved the network’s capability to diffuse innovation. We found that unanticipated effects could result, depending on the requirements of the policy and the proportion of health officials involved. With carefully crafted assumptions and reliable data it is possible to untangle complex processes using simulation modeling. The results represent how the world might actually work which may provide useful decision support for policymakers …