Medicine and Health Sciences Commons^™

Development And Promotion In Translational Medicine: Perspectives From 2012 Sino-American Symposium On Clinical And Translational Medicine, Mengjia Qian, Duojiao Wu, Ena Wang, Francesco Marincola, Wei Wang, William Rhodes, Michael Liebman, Chunxue Bai, Ching-Wan Lam, Gyorgy Marko-Varga, Thomas Fehniger, Roland Andersson, Xiangdong Wang

Research outputs 2012

Background Clinical translational medicine (CTM) is an emerging area comprising multidisciplinary research from basic science to medical applications and entails a close collaboration among hospital, academia and industry. Findings This Session focused discussing on new models for project development and promotion in translational medicine. The conference stimulated the scientific and commercial communication of project development between academies and companies, shared the advanced knowledge and expertise of clinical applications, and created the environment for collaborations. Conclusions Although strategic collaborations between corporate and academic institutions have resulted in a state of resurgence in the market, new cooperation models still need time to …

The Invisibility Of Covert Bullying Among Students: Challenges For School Intervention, Amy Barnes, Donna Cross, Leanne Lester, Lydia Hearn, Melanie Epstein, Helen Monks

Research outputs 2012

Covert bullying behaviours are at least as distressing for young people as overt forms of bullying, but often remain unnoticed or unacknowledged by adults. This invisibility is increased in schools by inattention to covert bullying in policy and practice, and limited staff understanding and skill to address covert behaviours. These factors can lead to a school culture that appears to tolerate and thus inadvertently encourages covert bullying. This study explores these dynamics in Australian primary and secondary schools, including the attitudes of over 400 staff towards covert bullying, their understanding of covert bullying behaviours, and their perceived capacity to address …

A Theoretically Grounded Exploration Of The Social And Emotional Outcomes Of Transition To Secondary School, Stacey Waters, Leanne Lester, Elizabeth Wenden, Donna Cross

Research outputs 2012

Adolescent development involves a complex interplay between genetics, biology, and social and emotional relationships within multiple contexts of home, school and the broader community. The transition from primary to secondary school, coupled with the onset of puberty, can therefore be a difficult period for young people to negotiate at a critical period of their developmental pathway. Using a social ecological perspective, this article examines the impact of the transition experience on adolescent social and emotional health, both immediately following transition to secondary school and at the end of the first year in this new school environment. This 1-year prospective study …

Internalising Symptoms: An Antecedent Or Precedent In Adolescent Peer Victimisation?, Leanne Lester, Donna Cross, Julian Dooley, Therese Shaw

Research outputs 2012

The transition period from primary to secondary school is a critical time in adolescent development. The high prevalence of adolescent mental health problems makes understanding the causal pathways between peer victimisation and internalising symptoms an important priority during this time. This article utilises data collected from self-completion questionnaires four times over 3 years from 3,459 students’ aged 11–14 to examine directional relationships among adolescents as they transition from primary to secondary school, and investigates gender differences in these associations. The findings suggest depression in males is both a precedent and antecedent for victimisation over the transition period, whereas for females …

Anxiety, Depression And Comorbid Anxiety And Depression: Risk Factors And Outcome Over Two Years, Osvaldo Almeida, Brian Draper, Jane Pirkis, John Snowdon, Nicola Lautenschlager, Gerard Byrne, Moira Sim, Nigel Stocks, Ngaire Kerse, Leon Flicker, Jon Pfaff

Research outputs 2012

Background: This study aimed to determine: (1) the prevalence of depression, anxiety, and depression associated with anxiety (DA); (2) the risk factor profile of depression, anxiety, and DA; (3) the course of depression, anxiety, and DA over 24 months. Methods: Two-year longitudinal study of 20,036 adults aged 60+ years. We used the Patient Health Questionnaire and the Hospital Anxiety and Depression Scale anxiety subscale to establish the presence of depression and anxiety, and standard procedures to collect demographic, lifestyle, psychosocial, and clinical data. Results: The prevalence of anxiety, depression, and DA was 4.7%, 1.4%, and 1.8%. About 57% of depression …

Encouraging Student Access To And Use Of Pastoral Care Services In Schools, Patricia Cardoso, Laura Thomas, Robyn Johnston, Donna Cross

Research outputs 2012

School-based health services (SBHS) including pastoral care can play a pivotal role in addressing adolescent health and wellbeing; including their tobacco and other drug use. To maximise the benefits of these services, they need to be accessible, useful for, and acceptable to students. This formative, qualitative study involved 12 focus groups within nine lower socio-economic Western Australian Government secondary schools. The purpose was to identify student (n = 59) perceptions of the availability and usefulness of SBHS (and other identified caring staff) to reduce students' harm associated with tobacco and other drug use. The findings suggest students were aware of …

Early Diet Quality In A Longitudinal Study Of Australian Children: Associations With Nutrition And Body Mass Index Later In Childhood And Adolescence, Claire Meyerkort, Wendy H. Oddy, Therese O'Sullivan, J Henderson, Craig Pennell

Research outputs 2012

Obesity has origins extending to antenatal and early postnatal periods; however, the relationship between early postnatal diet and subsequent obesity is not well defined. The aims of this study were to determine whether early childhood dietary quality was associated with (a) infant and adolescent nutrition and (b) body mass index (BMI) in childhood and adolescence. The degree to which early nutrition and growth factors determine BMI throughout childhood and adolescence was also explored. This research was conducted using the Raine Study, a longitudinal survey of Australian children assessed from mid-gestation to 17 years of age. A dietary quality index, the …

Maternal Work Hours In Early To Middle Childhood Link To Later Adolescent Diet Quality, Jianghong Li, Therese O'Sullivan, Sarah Johnson, Fiona Stanley, Wendy H. Oddy

Research outputs 2012

Objective: Previous studies on maternal work hours and child diet quality have reported conflicting findings possibly due to differences in study design, lack of a comprehensive measure of diet quality and differing ages of the children under investigation. The present study aimed to prospectively examine the impact of parental work hours from age 1 year to age 14 years on adolescent diet quality.

Design: Multivariate linear regression models were used to examine independent associations between parents' work hours at each follow-up and across 14 years and adolescent diet quality at age 14 years. A diet quality index was based on …

Anxiety, Depression, And Comorbid Anxiety And Depression: Risk Factors And Outcome Over Two Years, O P Almeida, B Draper, J Pirkis, J Snowdon, N T Lautenschlager, G Byrne, Moira Sim, N Stocks, N Kerse, L Flicker, J J Pfaff

Research outputs 2012

Background: This study aimed to determine: (1) the prevalence of depression, anxiety, and depression associated with anxiety (DA); (2) the risk factor profile of depression, anxiety, and DA; (3) the course of depression, anxiety, and DA over 24 months. Methods: Two-year longitudinal study of 20,036 adults aged 60+ years. We used the Patient Health Questionnaire and the Hospital Anxiety and Depression Scale anxiety subscale to establish the presence of depression and anxiety, and standard procedures to collect demographic, lifestyle, psychosocial, and clinical data. Results: The prevalence of anxiety, depression, and DA was 4.7%, 1.4%, and 1.8%. About 57% of depression …

Lifestyle And Late Life Cognitive Health: Sufficient Evidence To Act Now?, Bruce Barber, D Ames, Kathryn Ellis, Ralph Martins, C Masters, C Szoeke

Research outputs 2012

No abstract provided.

Predictors Of Rapid Cognitive Decline In Alzheimer's Disease: Results From The Australian Imaging, Biomarkers And Lifestyle (Aibl) Study Of Ageing, A Sona, P Zhang, D Ames, A I Bush, N T Lautenschlager, Ralph Martins, C L Masters, C C Rowe, C Szoeke, Kevin Taddei, Kathryn A Ellis

Research outputs 2012

Background: The AIBL study, which commenced in November 2006, is a two-center prospective study of a cohort of 1112 volunteers aged 60+. The cohort includes 211 patients meeting NINCDS-ADRDA criteria for Alzheimer's disease (AD) (180 probable and 31 possible). We aimed to identify factors associated with rapid cognitive decline over 18 months in this cohort of AD patients.

Methods: We defined rapid cognitive decline as a drop of 6 points or more on the Mini-Mental State Examination (MMSE) between baseline and 18-month follow-up. Analyses were also conducted with a threshold of 4, 5, 7 and 8 points, as well as …

Is The Construction Induction Training Scheme In The Housing And Civil Construction Industries Of Western Australia Effective In Improving Safety Culture?, Susanne Bahn, Llandis Barratt-Pugh

Research outputs 2012

This paper presents the findings of a 2011 study that evaluated the effectiveness of the Construction Induction Training (CIT) scheme (White Card) in the housing and civil construction sectors. This mixed method study collected data in three phases through: the segregated statistics of the Lost Time Injuries and Diseases (LTI/Ds), a broad industry questionnaire, and 82 interviews with managers and construction workers working in metropolitan and regional areas. The main findings indicate that there is broad acceptance of the benefits of the training across all stakeholder groups. The statistics show that there was a slight rise in LTI/Ds in the …

Hard Or Soft? The Relationship Between Power And Organisational Incident Rates, Susanne Bahn, Llandis Barratt-Pugh

Research outputs 2012

This paper examines the power that managers have to impact on workplace safety and how in mixed method studies our preconceptions about the hardness and softness of the relevant data may be misplaced. The civil construction industry (CCI) in WA provides the case for this discussion. Workers in this industry are constantly battling between safety compliance and production pressures in an era of economic boom. The examination of 3,882 incident reports, upon which this paper’s conclusions are drawn, revealed that these ‘‘hard’’ data may often obscure incidents that occur as organisations may be pressured into providing reportable incident figures that …

Construction Induction Training: Does Mandatory Training Work?, Susanne Bahn

Research outputs 2012

Reducing the high level of deaths and injuries in the construction industry is a continual challenge. It is a specific challenge in Western Australia (WA), where the industry is adapting to the additional pressures of a resources-led development boom. In 2006, Worksafe WA responded by introducing mandatory certification in basic safety training for all employees, before they could set foot on a work site. This paper reviews the impact of this training initiative on the commercial sector of the construction industry, the training organisations, and the construction employees. The mixed methodology study collects both the perceptions of the stakeholders and …

The Impact Of Management Styles Upon Organisational Change And Safety Cultures, Susanne Bahn, Llandis Barratt-Pugh

Research outputs 2012

In this paper we discuss the findings of two large studies conducted during 2005/06 that illuminated the role of managers as change agents. We draw the findings together to conceptualise and model the leadership styles and behaviours that appear to be successful in reshaping organisational safety culture. The first study identified the instrumental influence that managers have on the safety culture within organisations. The second study revealed the influential role of managers as change agents during a cultural change initiative when they applied a flexible approach using formal and informal agencies of change. The paper situates these two studies in …

Workplace Hazard Identification: What Do Workers In Mining Know?, Susanne Bahn

Research outputs 2012

This paper presents the findings of a study conducted in 2011/2012 that investigated the skills of new entrants to the mining industry’s skills in identifying workplace hazards from photographs of their work areas and strategies to improve these practices identified by health and safety managers. The findings of phase one of the study indicated that there was a greater ability to identify the hazards by those with 6–10 years experience and aged 34–45 years. Phase two of the study, which is the topic of this paper, identified training, communication and documentation as important to improve hazard identification skills. Other strategies …

An Investigation Of Health Problems Among Female Hairdressers In Western Australia, Mary O'Loughlin, Jacques Oosthuizen

Research outputs 2012

Female hairdressers in Western Australia were surveyed to determine the occurrence of health problems that may be associated with their work environment. The cohort of 238 hairdressers reported poor health behaviours including a poor dietary and fluid intake; a high prevalence of smoking; and a low level of glove usage when undertaking wet work and handling non-discolouring chemicals. Younger hairdressers were found to be most at risk of increased respiratory illness, musculoskeletal problems, skin conditions, bowel issues and general poor health. When compared with data obtained from the Australian Longitudinal Study on Women’s Health (ALSWH), younger hairdressers reported a higher …

Limitations Associated With The Pooling Of Historical Data Sets: An Analysis Of Dust Monitoring Data Collected At A Typical Remote Australian Mine 2004 - 2008, Jacques Oosthuizen

Research outputs 2012

Dust monitoring data collected over a period of 5 years at a remote Australian mine site were pooled in order to create a large data set for analysis. Results adjusted for a 12-hour shift were compared to exposure standards and 90% of the respirable and 97% of the inhalable dust samples were found to be within the exposure standards. Median values appear to better describe exposures than the mean which is influenced by outliers. There was a declining trend in respirable dust results over time. However, inhalable dust levels remained fairly constant over the sampling period. Inhalable dust levels were …

A Theory Of The Mind As A Complex System, Craig Speelman, Kim Kirsner, Stephan Halloy

Research outputs 2012

Five principles of skill acquisition are presented based on a review of research on human learning and expertise. Essentially these principles state that practice leads to faster and more efficient uses of knowledge. This enables faster performance and results in less demand on mental resources. In turn these outcomes enable higher level behaviours to be attempted. Ultimately skills are developed through refinement of many component processes. A theory of the mind is proposed that borrows from theories of complex adaptive systems. In this theory, the mind is conceived of as consisting of agents that compete for resources associated with processing …

The Development Of An Interdisciplinary Research Agenda At Ngala: An Innovative Case Study, E Bennett, Y Hauck, S Bindahneem, Vicki Banham, M Owens, L E Priddis, G Wells, W Sinclair, L Shields

Research outputs 2012

Background Ngala is an early parenting, not-for-profit organisation in Western Australia (WA). Research academics from three universities in Perth had been involved in separate research activities over recent years at Ngala. During 2007, a strategic decision was made to forge formal links and articulate an interdisciplinary research framework to promote a research culture amongst Ngala practitioners. Aim To describe an organisational case study of the development of an interdisciplinary research agenda within Ngala. Methods Collaborative methods were used. An action learning project was undertaken over a two-year period with the involvement of researchers, managers and practitioners across the five disciplines …

The International Effort: Building The Bridge For Translational Medicine: Report Of The 1st International Conference Of Translational Medicine (Ictm), Xiaoming Chen, Roland Andersson, William Cs Cho, David Christiani, Richard Coico, Jeffery Drazen, Markus Ege, Thomas Fehniger, Hongwei Gao, Kunlin Jin, Michael N. Liebman, Elena Lopez, Giuseppe Marraro, Gyorgy Marko-Varga, Francesco M. Marincola, Laurentiu M. Popescu, Claudio Spada, Aamir Shahzad, Ena Wang, Wei Wang, Xiangdong Wang, Yong-Xiao Wang, Jinglin Xia, Jia Qu

Research outputs 2012

Background : Supported by the International Society for Translational Medicine (ISTM), Wenzhou Medical College and the First Affiliated Hospital of Wenzhou Medical College, the International Conference on Translational Medicine (ICTM) was held on October 22–23, 2011 in Wenzhou, China. Nearly 800 registrants attended the meeting, primarily representing institutes and hospitals in Europe, The United States of America, And Asia, and China. The meeting was chaired and organized by Dr. Xiangdong Wang, Xiaoming Chen, Richard Coico, Jeffrey M. Drazen, Richard Horton, Francesco M. Marincola, Laurentiu M. Popescu, Jia Qu and Aamir Shahzad.

Findings : The meeting focused on the communication of …

Lsk Derived Lsk– Cells Have A High Apoptotic Rate Related To Survival Regulation Of Hematopoietic And Leukemic Stem Cells, Cong Peng, Yaoyu Chen, Yi Shan, Haojian Zhang, Zhiru Guo, Dongguang Li, Shaoguang Li

Research outputs 2012

A balanced pool of hematopoietic stem cells (HSCs) in bone marrow is tightly regulated, and this regulation is disturbed in hematopoietic malignancies such as chronic myeloid leukemia (CML). The underlying mechanisms are largely unknown. Here we show that the Lin⁻Sca-1⁺c-Kit^- (LSK⁻) cell population derived from HSC-containing Lin⁻Sca-1⁺c-Kit⁺ (LSK) cells has significantly higher numbers of apoptotic cells. Depletion of LSK cells by radiation or the cytotoxic chemical 5-fluorouracil results in an expansion of the LSK⁻ population. In contrast, the LSK⁻ population is reduced in CML mice, and …

Biomedical Image Signal Processing For Reflection-Based Imaging, Paul Jansz, Steven Richardson, Graham Wild, Steven Hinckley

Research outputs 2012

Optical coherence tomography (OCT), ultrasound and other reflection based biomedical imaging technologies involve image signal processing that is primarily a filtering, digitizing and summing process so that the tissue cross-section can be visualized. In particular, in OCT, a series of adjacent one dimensional in-vivo axial interferograms (A-scan) are summed to form a two dimensional (B-scan) reflection map or reflectogram. Further graphical combinations can add adjacent B-scan together to form three dimensional C-scans. A physician can make a subjective interpretation and evaluation from the B and/or C-scans that may lead to actions impacting on the patient’s prognosis. More objective information can …

The Fate Of Frozen Human Embryos When Transferred Either On The Day Ofthawing Or After Overnight Culture, Yanhe Liu, Kellie Peirce, Kailin Yap, Kate Mckenzie, Jay Natalwala, Vince Chapple, Margo Norman, Phillip Matson

Research outputs 2012

Objective: To study the performance of thawed zygotes and cleavage stage embryos transferred either on the day of thaw or after overnight culture. Methods: A retrospective study of 864 frozen embryo transfer cycles. Cryosurvival rates per thawed embryo and implantation rates were analysed for embryos frozen on Day 1, Day 2 or Day 3 relative to oocyte collection (Day 0) and transferred on the day of thaw or after overnight culture, together with clinical pregnancy rates and prevalence of multiple gestations. Results: Survival of Day 3 embryos was significantly lower than those frozen on Day 1 (P=0.017) or Day 2 …

Human Semen Can Be Air-Dried Prior To Testing For Sperm Dna Fragmentation With The Halosperm® G2 Kit, Kailin Yap, Phillip Matson

Research outputs 2012

Objective: To explore a method of semen storage prior to assessment of sperm DNA fragmentation. Methods: This study examined a simplified alternative of air-drying semen on a microscope slide and reconstituting in seminal plasma prior to assessment of sperm DNA fragmentation using the halosperm® G2 kit. Results: It showed that semen could be air-dried and stored overnight at room temperature with no detrimental effect on DNA quality. A significant correlation between results existed for 20 semen samples both air-dried and snap-frozen in liquid nitrogen (r=0.982, P=0.000). A mean difference between the results of only −1.98% confirmed the effectiveness of air-drying …

Changes In Upper Body Concentric Mean Power Output Resulting From Complex Training Emphasizing Concentric Muscle Actions, Daniel Baker

Research outputs 2012

Contrasting resistance complex (CRC) training is the alternating of sets of heavier and lighter resistances in an effort to evoke an acute increase in power output while lifting the lighter resistance. The effectiveness of CRC has been well established in elite athletes when researchers utilize an optimal manipulation of training variables but equivocal for other studies that have used a very heavy resistance to “stimulate” the neuro-muscular system. It was theorized that very heavy resistances could conceivably fatigue the processes associated with the stretch-shorten cycle (SSC). The purpose of this study was to determine the effects of CRC when utilizing …

Anthropometric Characteristics, Upper-Body Strength, And Sprint Paddling Performance In Competitive Surfers, Jeremy Sheppard, Mark Osborne, Dale Chapman, Mark Andrews

Research outputs 2012

The present study examined the potential differences in anthropometric characteristics, upper-body strength, and sprint paddling performance between youth and senior competitive surfers. Twenty competitive male surfers (19.1±6.8 years, 168.2±11.3 cm, 61.7±13.6 kg) were assessed for stature, mass, arm-span, ∑ 7 site skinfold thickness, Lean-Mass Ratio (LMR, ∑ 7 site skinfold/kg body-mass), pronated pull-up 1 repetition maximum (1 RM) and sprint paddling performance from a stationary start to 15 m. Independent t-tests were used to compare potential differences between youth (n:10) and senior group (n:10) of competitive surfers, with Cohen’s Effect Size (d) applied to reflect the magnitude of any differences …

Acute Effects Of Three Different Stretching Protocols On The Wingate Test Performance, B L Franco, G R Signorelli, Gabriel Trajano, P B Costa, C G De Oliveira

Research outputs 2012

The purpose of this study was to examine the acute effects of different stretching exercises on the performance of the traditional Wingate test (WT). Fifteen male participants performed five WT; one for familiarization (FT), and the remaining four after no stretching (NS), static stretching (SS), dynamic stretching (DS), and proprioceptive neuromuscular facilitation (PNF). Stretches were targeted for the hamstrings, quadriceps, and calf muscles. Peak power (PP), mean power (MP), and the time to reach PP (TP) were calculated. The MP was significantly lower when comparing the DS (7.7 ± 0.9 W/kg) to the PNF (7.3 ± 0.9 W/kg) condition (p < 0.05). For PP, significant differences were observed between more comparisons, with PNF stretching providing the lowest result. A consistent increase of TP was observed after all stretching exercises when compared to NS. The results suggest the type of stretching, or no stretching, should be considered by those who seek higher performance and practice sports that use maximal anaerobic power.

Practicing Field Hockey Skills Along The Contextual Interference Continuum: A Comparison Of Five Practice Schedules, Jadeera Cheong, Brendan Lay, J. Robert Grove, Nikola Medic, Rizal Razman

Research outputs 2012

To overcome the weakness of the contextual interference (CI) effect within applied settings, Brady (2008) recommended that the amount of interference be manipulated. This study investigated the effect of five practice schedules on the learning of three field hockey skills. Fifty-five pre-university students performed a total of 90 trials for each skill under blocked, mixed or random practice orders. Results showed a significant time effect with all five practice conditions leading to improvements in acquisition and learning of the skills. No significant differences were found between the groups. The findings of the present study did not support the CI effect …

Evidence For A Non-Genomic Action Of Testosterone In Skeletal Muscle Which May Improve Athletic Performance: Implications For The Female Athlete, J R Dent, D K Fletcher, Michael Mcguigan

Research outputs 2012

This review will focus on the proposed second mode of testosterone action (now termed non-genomic) that appears to occur independently of the traditional transcriptional mechanism in mammalian skeletal muscle cells which may enhance skeletal muscle contractile properties. This mechanism of testosterone action differs from the traditional pathway, originating at the cell membrane, having a rapid onset of action, requiring second messengers to execute its effects and is insensitive to inhibitors of traditional androgen receptor action, transcription and protein synthesis. Importantly, unlike the traditional action of testosterone in skeletal muscle, this non-genomic pathway is shown to have a direct acute effect …