Medicine and Health Sciences Commons^™

The Hippo Pathway Member Yap Plays A Key Role In Influencing Fate Decisions In Muscle Satellite Cells, Robert Judson, Annie Tremblay, Paul Knopp, Robert White, Roby Urcia, Cosimo De Bari, Peter Zammit, Fernando Camargo, Henning Wackerhage

Research outputs 2012

Satellite cells are the resident stem cells of skeletal muscle. Mitotically quiescent in mature muscle, they can be activated to proliferate and generate myoblasts to supply further myonuclei to hypertrophying or regenerating muscle fibres, or self-renew to maintain the resident stem cell pool. Here, we identify the transcriptional co-factor Yap as a novel regulator of satellite cell fate decisions. Yap expression increases during satellite cell activation and Yap remains highly expressed until after the differentiation versus self-renewal decision is made. Constitutive expression of Yap maintains Pax7+ and MyoD+ satellite cells and satellite cell-derived myoblasts, promotes proliferation but prevents differentiation. In …

A Phenomenological Exploration Of The Childfree Choice In A Sample Of Australian Women, Joanne Doyle, Julie Ann Pooley, Lauren Breen

Research outputs 2012

Choosing not to have children is considered a deviation from cultural norms, particularly the dominant pronatalist discourse; this is especially so for women. However, little research has documented the experience of Australian women who have consciously chosen to remain childless. Ten voluntarily childfree women participated in unstructured interviews about their choice and its ramifications. The data analysis revealed three broad themes – the experiences and processes of making the choice; the ongoing effects of their choice, ranging from support and acceptance to pressure and discrimination; and no regret as the women described engaging in meaningful, generative activities that contributed to …

Crime Prevention: The Role Of Individual Resilience Within The Family, Catherine Ferguson, Craig Harms, Julie Ann Pooley, Lynne Cohen, Stuart Tomlinson

Research outputs 2012

Resilience is context dependent but for resilience to be present, two elements must co-occur: adversity (i.e., high-risk situation/threat) and successful adaptation/competence. An understanding of resilience is important for professionals dealing with at-risk families. This exploratory research investigated how individuals caring for a family member with a mental illness adapted to the role of carer or supporter. Fifteen participants mostly aged 50 years or more were interviewed. Content analysis was used to develop themes from the interview transcripts. Seven themes were elicited from the data. Three of these fit with existing knowledge about challenges faced by offenders’ families. The article concludes …

Posttraumatic Stress And Posttraumatic Growth And Their Relationship To Coping And Self-Efficacy In Northwest Australian Cyclone Communities, Julie Ann Pooley, Lynne Cohen, Moira O'Conner, Myra Taylor

Research outputs 2012

The main focus of disaster research conducted to date has been on providing insights into the negative consequences of experiencing a serious threat or adversity. The present study extends this research endeavor by investigating the positive posttrauma resiliency experiences of 512 survey respondents living in four cyclone-prone communities in Northwest Australia. The findings reveal that disaster stress is often accompanied by disaster growth and, thus, provides an alternative resilience-based way of viewing postdisaster interventions.

The Use Of Naltrexone In Pregnancy In Opiate-Dependent Mothers, Sadie Geraghty, Carly Dixon

Research outputs 2012

There is an absence of sufficient evidence regarding naltrexone use in pregnancy due to the limited range of human studies. Naltrexone implants are being used in Western Australia as a treatment for opioid dependency, and although contraindicated for insertion during pregnancy, there are a number of women who conceive while undergoing treatment. A review of the available data revealed that naltrexone is associated with improved maternal and fetal outcomes. Extensive research into this area in the form of large, multicentre trials is required to confirm the results of the current research.

Inhibition Of Protein Translocation At The Endoplasmic Reticulum Promotes Activation Of The Unfolded Protein Response, Craig Mckibbin, Alina Mares, Michela Piacenti, Helen Williams, Peristera Roboti, Marjo Puumalainen, Anna Callan, Karolina Lesiak-Mieczkowska, Stig Linder, Hanna Harant, Stephen High, Sabine Flitsch, Roger Whitehead, Eileithyia Swanton

Research outputs 2012

Selective small-molecule inhibitors represent powerful tools for the dissection of complex biological processes. ESI (eeyarestatin I) is a novel modulator of ER (endoplasmic reticulum) function. In the present study, we show that in addition to acutely inhibiting ERAD (ER-associated degradation), ESI causes production of mislocalized polypeptides that are ubiquitinated and degraded. Unexpectedly, our results suggest that these non-translocated polypeptides promote activation of the UPR (unfolded protein response), and indeed we can recapitulate UPR activation with an alternative and quite distinct inhibitor of ER translocation. These results suggest that the accumulation of non-translocated proteins in the cytosol may represent a novel …

Effects Of Short-Term Training With Uncoupled Cranks In Trained Cyclists, Jack Burns, Jeremiah Peiffer, Chris Abbiss, Greig Watson, Angus Burnett, Paul Laursen

Research outputs 2012

Purpose: Manufacturers of uncoupled cycling cranks claim that their use will increase economy of motion and gross efficiency. Purportedly, this occurs by altering the muscle-recruitment patterns contributing to the resistive forces occurring during the recovery phase of the pedal stroke. Uncoupled cranks use an independentclutch design by which each leg cycles independently of the other (ie, the cranks are not fixed together). However, research examining the efficacy of training with uncoupled cranks is equivocal. The purpose of this study was to determine the effect of short-term training with uncoupled cranks on the performance-related variables economy of motion, gross efficiency, maximal …

Two Maximal Isometric Contractions Attenuate The Magnitude Of Eccentric Exercise-Induced Muscle Damage, Hsin-Lian Chen, Kazunori Nosaka, Alan Pearce, Trevor C Chen

Research outputs 2012

This study investigated whether maximal voluntary isometric contractions (MVC-ISO) would attenuate the magnitude of eccentric exercise-induced muscle damage. Young untrained men were placed into one of the two experimental groups or one control group (n = 13 per group). Subjects in the experimental groups performed either two or 10 MVC-ISO of the elbow flexors at a long muscle length (20° flexion) 2 days prior to 30 maximal isokinetic eccentric contractions of the elbow flexors. Subjects in the control group performed the eccentric contractions without MVC-ISO. No significant changes in maximal voluntary concentric contraction peak torque, peak torque angle, range of …

Lower Extremity Kinematics And Kinetics When Landing From Unloaded And Loaded Jumps, Ina Janssen, Jeremy Sheppard, Andrew Dingley, Dale Chapman, Wayne Spratford

Research outputs 2012

Countermovement jumps loaded with a weighted vest are often used for the training of lower body power to improve jump performance. However, it is currently unknown how this added load affects the lower extremity kinematics and kinetics, in particular whether this results in an increased injury risk. Therefore, the purpose of this investigation was to determine how lower extremity kinematics and kinetics during landing are affected by loaded jumps as demonstrated in a volleyball block jump landing. Ten elite male volleyball players performed block jump landings in an unloaded and loaded (9.89 kg) condition. Kinematic and kinetic landing data from …

Strength Gains: Block Versus Daily Undulating Periodization Weight Training Among Track And Field Athletes, Keith Painter, Guy Haff, Michael Ramsey, Jeff Mcbride, Travise Triplett, William Sands, Hugh Lamont, Margaret Stone, Michael Stone

Research outputs 2012

Recently, the comparison of "periodized" strength training methods has been a focus of both exercise and sport science. Daily undulating periodization (DUP), using daily alterations in repetitions, has been developed and touted as a superior method of training, while block forms of programming for periodization have been questioned. Therefore, the purpose of this study is to compare block to DUP in Division I track and field athletes. Thirty-one athletes were assigned to either a 10-wk block or DUP training group in which sex, year, and event were matched. Over the course of the study, there were 4 testing sessions, which …

Performance Analysis Of A World-Class Sprinter During Cycling Grand Tours, Paolo Menaspà, Chris Abbiss, David Martin

Research outputs 2012

This investigation describes the sprint performances of the highest internationally ranked professional male road sprint cyclist during the 2008-2011 Grand Tours. Sprint stages were classified as won, lost, or dropped from the front bunch before the sprint. Thirty-one stages were video-analyzed for average speed of the last km, sprint duration, position in the bunch, and number of teammates at 60, 30, and 15 s remaining. Race distance, total elevation gain (TEG), and average speed of 45 stages were determined. Head-to-head performances against the 2nd-5th most successful professional sprint cyclists were also reviewed. In the 52 Grand Tour sprint stages the …

To The Heart Of The Problem. Migf-1: Local Effort For Global Impact, Antonio Musaro

Research outputs 2012

No abstract provided.

Moving Beyond Tyrosine Hydroxylase To Define Dopaminergic Neurons For Use In Cell Replacement Therapies For Parkinson's Disease, Robert White, Meghan Thomas

Research outputs 2012

Cell replacement therapies are an attractive mode of treatment for neurodegenerative disorders as they have the potential to alleviate or modify disease symptoms and restore function. In Parkinson's disease, the cell type requiring replacement is dopamine-producing neurons of the midbrain. The source of replacement cells is contentious, with opinion still evolving. Clinical trials have previously used fetal brain tissue; however, this will likely be superseded by the use of embryonic or induced pluripotent stem cells, due to their greater availability and homogeneity. One significant caveat in the use of any cell source for therapy is that cells must first be …

Association Between The G-Protein Β3 Subunit C825t Polymorphism With Essential Hypertension: A Meta-Analysis In Han Chinese Population, Jaipeng Lu, Q Guo, Ling Zhang, Wei Wang

Research outputs 2012

We aimed to evaluate the contribution of the G-protein β3 subunit C825T (GNB3-C825T) polymorphism to essential hypertension (EH) in Han Chinese population by performing meta-analysis. A meta-analysis was performed in 12 case–control genetic association studies including 3,020 hypertension patients and 2,790 controls from MEDLINE (PubMed) and the China National Knowledge Infrastructure platforms. The STATA 10.0 software was used in analysis. Overall, there was no significant association between the GNB3-C825T polymorphism and EH in neither additive [TT vs. CC: OR (95 % CI) = 1.11 (0.74–1.69), P = 0.61; TC vs. CC: OR (95 % CI) = 1.08 (0.89–1.31), P = …

Development And Promotion In Translational Medicine: Perspectives From 2012 Sino-American Symposium On Clinical And Translational Medicine, Mengjia Qian, Duojiao Wu, Ena Wang, Francesco Marincola, Wei Wang, William Rhodes, Michael Liebman, Chunxue Bai, Ching-Wan Lam, Gyorgy Marko-Varga, Thomas Fehniger, Roland Andersson, Xiangdong Wang

Research outputs 2012

Background Clinical translational medicine (CTM) is an emerging area comprising multidisciplinary research from basic science to medical applications and entails a close collaboration among hospital, academia and industry. Findings This Session focused discussing on new models for project development and promotion in translational medicine. The conference stimulated the scientific and commercial communication of project development between academies and companies, shared the advanced knowledge and expertise of clinical applications, and created the environment for collaborations. Conclusions Although strategic collaborations between corporate and academic institutions have resulted in a state of resurgence in the market, new cooperation models still need time to …

The Invisibility Of Covert Bullying Among Students: Challenges For School Intervention, Amy Barnes, Donna Cross, Leanne Lester, Lydia Hearn, Melanie Epstein, Helen Monks

Research outputs 2012

Covert bullying behaviours are at least as distressing for young people as overt forms of bullying, but often remain unnoticed or unacknowledged by adults. This invisibility is increased in schools by inattention to covert bullying in policy and practice, and limited staff understanding and skill to address covert behaviours. These factors can lead to a school culture that appears to tolerate and thus inadvertently encourages covert bullying. This study explores these dynamics in Australian primary and secondary schools, including the attitudes of over 400 staff towards covert bullying, their understanding of covert bullying behaviours, and their perceived capacity to address …

A Theoretically Grounded Exploration Of The Social And Emotional Outcomes Of Transition To Secondary School, Stacey Waters, Leanne Lester, Elizabeth Wenden, Donna Cross

Research outputs 2012

Adolescent development involves a complex interplay between genetics, biology, and social and emotional relationships within multiple contexts of home, school and the broader community. The transition from primary to secondary school, coupled with the onset of puberty, can therefore be a difficult period for young people to negotiate at a critical period of their developmental pathway. Using a social ecological perspective, this article examines the impact of the transition experience on adolescent social and emotional health, both immediately following transition to secondary school and at the end of the first year in this new school environment. This 1-year prospective study …

Internalising Symptoms: An Antecedent Or Precedent In Adolescent Peer Victimisation?, Leanne Lester, Donna Cross, Julian Dooley, Therese Shaw

Research outputs 2012

The transition period from primary to secondary school is a critical time in adolescent development. The high prevalence of adolescent mental health problems makes understanding the causal pathways between peer victimisation and internalising symptoms an important priority during this time. This article utilises data collected from self-completion questionnaires four times over 3 years from 3,459 students’ aged 11–14 to examine directional relationships among adolescents as they transition from primary to secondary school, and investigates gender differences in these associations. The findings suggest depression in males is both a precedent and antecedent for victimisation over the transition period, whereas for females …

Anxiety, Depression And Comorbid Anxiety And Depression: Risk Factors And Outcome Over Two Years, Osvaldo Almeida, Brian Draper, Jane Pirkis, John Snowdon, Nicola Lautenschlager, Gerard Byrne, Moira Sim, Nigel Stocks, Ngaire Kerse, Leon Flicker, Jon Pfaff

Research outputs 2012

Background: This study aimed to determine: (1) the prevalence of depression, anxiety, and depression associated with anxiety (DA); (2) the risk factor profile of depression, anxiety, and DA; (3) the course of depression, anxiety, and DA over 24 months. Methods: Two-year longitudinal study of 20,036 adults aged 60+ years. We used the Patient Health Questionnaire and the Hospital Anxiety and Depression Scale anxiety subscale to establish the presence of depression and anxiety, and standard procedures to collect demographic, lifestyle, psychosocial, and clinical data. Results: The prevalence of anxiety, depression, and DA was 4.7%, 1.4%, and 1.8%. About 57% of depression …

Encouraging Student Access To And Use Of Pastoral Care Services In Schools, Patricia Cardoso, Laura Thomas, Robyn Johnston, Donna Cross

Research outputs 2012

School-based health services (SBHS) including pastoral care can play a pivotal role in addressing adolescent health and wellbeing; including their tobacco and other drug use. To maximise the benefits of these services, they need to be accessible, useful for, and acceptable to students. This formative, qualitative study involved 12 focus groups within nine lower socio-economic Western Australian Government secondary schools. The purpose was to identify student (n = 59) perceptions of the availability and usefulness of SBHS (and other identified caring staff) to reduce students' harm associated with tobacco and other drug use. The findings suggest students were aware of …

Early Diet Quality In A Longitudinal Study Of Australian Children: Associations With Nutrition And Body Mass Index Later In Childhood And Adolescence, Claire Meyerkort, Wendy H. Oddy, Therese O'Sullivan, J Henderson, Craig Pennell

Research outputs 2012

Obesity has origins extending to antenatal and early postnatal periods; however, the relationship between early postnatal diet and subsequent obesity is not well defined. The aims of this study were to determine whether early childhood dietary quality was associated with (a) infant and adolescent nutrition and (b) body mass index (BMI) in childhood and adolescence. The degree to which early nutrition and growth factors determine BMI throughout childhood and adolescence was also explored. This research was conducted using the Raine Study, a longitudinal survey of Australian children assessed from mid-gestation to 17 years of age. A dietary quality index, the …

Maternal Work Hours In Early To Middle Childhood Link To Later Adolescent Diet Quality, Jianghong Li, Therese O'Sullivan, Sarah Johnson, Fiona Stanley, Wendy H. Oddy

Research outputs 2012

Objective: Previous studies on maternal work hours and child diet quality have reported conflicting findings possibly due to differences in study design, lack of a comprehensive measure of diet quality and differing ages of the children under investigation. The present study aimed to prospectively examine the impact of parental work hours from age 1 year to age 14 years on adolescent diet quality.

Design: Multivariate linear regression models were used to examine independent associations between parents' work hours at each follow-up and across 14 years and adolescent diet quality at age 14 years. A diet quality index was based on …

Anxiety, Depression, And Comorbid Anxiety And Depression: Risk Factors And Outcome Over Two Years, O P Almeida, B Draper, J Pirkis, J Snowdon, N T Lautenschlager, G Byrne, Moira Sim, N Stocks, N Kerse, L Flicker, J J Pfaff

Research outputs 2012

Background: This study aimed to determine: (1) the prevalence of depression, anxiety, and depression associated with anxiety (DA); (2) the risk factor profile of depression, anxiety, and DA; (3) the course of depression, anxiety, and DA over 24 months. Methods: Two-year longitudinal study of 20,036 adults aged 60+ years. We used the Patient Health Questionnaire and the Hospital Anxiety and Depression Scale anxiety subscale to establish the presence of depression and anxiety, and standard procedures to collect demographic, lifestyle, psychosocial, and clinical data. Results: The prevalence of anxiety, depression, and DA was 4.7%, 1.4%, and 1.8%. About 57% of depression …

Lifestyle And Late Life Cognitive Health: Sufficient Evidence To Act Now?, Bruce Barber, D Ames, Kathryn Ellis, Ralph Martins, C Masters, C Szoeke

Research outputs 2012

No abstract provided.

Predictors Of Rapid Cognitive Decline In Alzheimer's Disease: Results From The Australian Imaging, Biomarkers And Lifestyle (Aibl) Study Of Ageing, A Sona, P Zhang, D Ames, A I Bush, N T Lautenschlager, Ralph Martins, C L Masters, C C Rowe, C Szoeke, Kevin Taddei, Kathryn A Ellis

Research outputs 2012

Background: The AIBL study, which commenced in November 2006, is a two-center prospective study of a cohort of 1112 volunteers aged 60+. The cohort includes 211 patients meeting NINCDS-ADRDA criteria for Alzheimer's disease (AD) (180 probable and 31 possible). We aimed to identify factors associated with rapid cognitive decline over 18 months in this cohort of AD patients.

Methods: We defined rapid cognitive decline as a drop of 6 points or more on the Mini-Mental State Examination (MMSE) between baseline and 18-month follow-up. Analyses were also conducted with a threshold of 4, 5, 7 and 8 points, as well as …

Is The Construction Induction Training Scheme In The Housing And Civil Construction Industries Of Western Australia Effective In Improving Safety Culture?, Susanne Bahn, Llandis Barratt-Pugh

Research outputs 2012

This paper presents the findings of a 2011 study that evaluated the effectiveness of the Construction Induction Training (CIT) scheme (White Card) in the housing and civil construction sectors. This mixed method study collected data in three phases through: the segregated statistics of the Lost Time Injuries and Diseases (LTI/Ds), a broad industry questionnaire, and 82 interviews with managers and construction workers working in metropolitan and regional areas. The main findings indicate that there is broad acceptance of the benefits of the training across all stakeholder groups. The statistics show that there was a slight rise in LTI/Ds in the …

Hard Or Soft? The Relationship Between Power And Organisational Incident Rates, Susanne Bahn, Llandis Barratt-Pugh

Research outputs 2012

This paper examines the power that managers have to impact on workplace safety and how in mixed method studies our preconceptions about the hardness and softness of the relevant data may be misplaced. The civil construction industry (CCI) in WA provides the case for this discussion. Workers in this industry are constantly battling between safety compliance and production pressures in an era of economic boom. The examination of 3,882 incident reports, upon which this paper’s conclusions are drawn, revealed that these ‘‘hard’’ data may often obscure incidents that occur as organisations may be pressured into providing reportable incident figures that …

Construction Induction Training: Does Mandatory Training Work?, Susanne Bahn

Research outputs 2012

Reducing the high level of deaths and injuries in the construction industry is a continual challenge. It is a specific challenge in Western Australia (WA), where the industry is adapting to the additional pressures of a resources-led development boom. In 2006, Worksafe WA responded by introducing mandatory certification in basic safety training for all employees, before they could set foot on a work site. This paper reviews the impact of this training initiative on the commercial sector of the construction industry, the training organisations, and the construction employees. The mixed methodology study collects both the perceptions of the stakeholders and …

The Impact Of Management Styles Upon Organisational Change And Safety Cultures, Susanne Bahn, Llandis Barratt-Pugh

Research outputs 2012

In this paper we discuss the findings of two large studies conducted during 2005/06 that illuminated the role of managers as change agents. We draw the findings together to conceptualise and model the leadership styles and behaviours that appear to be successful in reshaping organisational safety culture. The first study identified the instrumental influence that managers have on the safety culture within organisations. The second study revealed the influential role of managers as change agents during a cultural change initiative when they applied a flexible approach using formal and informal agencies of change. The paper situates these two studies in …

Workplace Hazard Identification: What Do Workers In Mining Know?, Susanne Bahn

Research outputs 2012

This paper presents the findings of a study conducted in 2011/2012 that investigated the skills of new entrants to the mining industry’s skills in identifying workplace hazards from photographs of their work areas and strategies to improve these practices identified by health and safety managers. The findings of phase one of the study indicated that there was a greater ability to identify the hazards by those with 6–10 years experience and aged 34–45 years. Phase two of the study, which is the topic of this paper, identified training, communication and documentation as important to improve hazard identification skills. Other strategies …