Medicine and Health Sciences Commons^™

Cellular Retrograde Cardiomyoplasty And Relaxin Therapy For Postischemic Myocardial Repair In A Rat Model, Gabriella Di Lascio, Guy Harmelin, Mattia Targetti, Cristina Nanni, Giacomo Bianchi, Tommaso Gasbarri, Sandro Gelsomino, Daniele Bani, Sandra Zecchi Orlandini, Massimo Bonacchi

The Texas Heart Institute Journal

We sought to determine whether skeletal myoblasts, wild-type or engineered to express relaxin, might improve myocardial viability and performance in a rat model of chronic myocardial infarction. Our purpose was to investigate a potential new therapy for heart failure.

From October 2005 through September 2009, we surgically induced acute myocardial infarction in 80 male Wistar rats. Thirty days after surgery, the rats underwent reoperation for the retrograde coronary venous infusion of skeletal myoblasts, relaxin, or both. The animals were randomly assigned to 4 experimental groups: R1 (the control group, which underwent saline-solution infusion), R2 (systemic relaxin therapy), R3 (myoblast infusion), …

Carotid Artery Stenting Versus Endarterectomy: A Systematic Review, Amir Gahremanpour, Emerson C Perin, Guilherme Silva

The Texas Heart Institute Journal

For about 2 decades, investigators have been comparing carotid endarterectomy with carotid artery stenting in regard to their effectiveness and safety in treating carotid artery stenosis. We conducted a systematic review to summarize and appraise the available evidence provided by randomized trials, meta-analyses, and registries comparing the clinical outcomes of the 2 procedures. We searched the MEDLINE, SciVerse Scopus, and Cochrane databases and the bibliographies of pertinent textbooks and articles to identify these studies.

The results of clinical trials and, consequently, the meta-analyses of those trials produced conflicting results regarding the comparative effectiveness and safety of carotid endarterectomy and carotid …

Apical Hypertrophic Cardiomyopathy: Preliminary Attempt At Palliation With Use Of Subselective Alcohol Ablation, Paolo Angelini, Carlo Uribe, Jorge Monge, Jorge M Escobar, Eduardo Hernandez-Vila

The Texas Heart Institute Journal

We report a case of severe apical hypertrophic cardiomyopathy in order to discuss the nature of this unusual condition and the possibility of using selective alcohol ablation to effectively treat symptomatic hypertrophic cardiomyopathy that presents with apical aneurysm. A 73-year-old woman with severe, progressive dyspnea and intermittent chest pain was found to have localized left ventricular apical dyskinesia distal to an obstructive mid-distal muscular ring. The ring caused total systolic obliteration of the apical left ventricular cavity. Apical cavity pressure was extremely high, up to 330 mmHg-200 mmHg above that in the main left ventricular cavity. Because of the danger …

Intramyocardial Hematoma From Blunt Trauma Mimicking Apical Hypertrophic Cardiomyopathy, Meta Linda Mobula, Sammy Zakaria, Glenn A Hirsch

The Texas Heart Institute Journal

No abstract provided.

Mid-Aortic Syndrome In A 3-Year-Old Girl Successfully Treated By Aorto-Aortic Grafting And Renal Artery Implantation Into The Graft, Tanja Kersnik Levart, Tomislav Klokocovnik

The Texas Heart Institute Journal

Mid-aortic syndrome, an uncommon acquired or congenital condition characterized by segmental narrowing of the abdominal or distal descending thoracic aorta, is frequently accompanied by ostial stenosis of the aorta's branches. If left untreated, it can result in life-threatening complications secondary to severe hypertension.

We report the case of a 3-year-old girl with congenital mid-aortic syndrome, who was diagnosed by chance in the course of a viral illness, and whose high blood pressure values were first dismissed as inaccurate. Attempts to achieve medical or endovascular control of her hypertension were unsuccessful. She was thereafter successfully treated by aorto–aortic bypass grafting, resection …

Transcatheter Retrieval And Repositioning Of Embolized Stent From The Right Ventricle In An Infant, Daisuke Kobayashi, Harinder R Singh, Daniel R Turner, Thomas J Forbes, Srinath T Gowda

The Texas Heart Institute Journal

Intracardiac stent embolization is a challenging complication in a small infant. A Palmaz stent was placed across the atrial septum in a 3-month-old boy to relieve symptoms of right-side heart failure. On routine chest radiography one week later, the stent was found to have embolized into the right ventricle. The stent was retrieved and repositioned by means of transcatheter technique, without subsequent complications. We found this method to be a viable alternative to surgery in a high-risk infant. To our knowledge, this is the first report of the successful transcatheter retrieval and repositioning of an expandable intravascular stent from an …

Management Of Intra-Aortic Balloon Pump Entrapment: A Case Report And Review Of The Literature, Gerard J Fitzmaurice, Anton Collins, Haralambos Parissis

The Texas Heart Institute Journal

An intra-aortic balloon pump is one of the most valuable tools in the cardiac surgeon's armament to assist in the management of the failing heart. Despite its widespread use, there are associated risks and complications, one of which is balloon rupture with associated entrapment. Numerous approaches for dealing with this complication have been described; here we review the previous experience with intra-aortic balloon pump entrapment and discuss potential management, with particular reference to a recent case of our own.

Pulmonary Resection In The 21st Century: The Role Of Robotics, Robert J Cerfolio

The Texas Heart Institute Journal

No abstract provided.

The History Of Art Versus The Art Of Surgery, Ugo Filippo Tesler

The Texas Heart Institute Journal

No abstract provided.

Chronic Kidney Disease Is Associated With Increased Coronary Artery Atherosclerosis As Revealed By Multidetector Computed Tomographic Angiography, Sion K Roy, Albert Cespedes, Dong Li, Tae-Young Choi, Matthew J Budoff

The Texas Heart Institute Journal

Chronic kidney disease (CKD) is an independent risk factor for cardiovascular events. We evaluated whether multidetector computed tomographic angiography (MDCTA) revealed a link between pre-dialysis CKD and coronary artery atherosclerosis.

We retrospectively analyzed 549 patients who underwent MDCTA. Patients were divided into 3 groups: normal glomerular filtration rate (GFR) (GFR >90 mL/min/1.73 m2 body surface area), mild CKD (>60GFR≤90 mL/min/1.73 m2), and moderate CKD (>30GFR≤60 mL/min/1.73 m2). Normality testing was performed to determine if continuous variables were modeled in Gaussian distribution before analysis of variance was applied. The χ2 test was used to compare GFR subgroups. Multiple linear …

Aadej Comm 43 1&2 2012

AADEJ - The Communicator

The Communicator is the official journal of the American Association of Dental Editors and Journalists (AADEJ). It is published quarterly, distributed digitally via email to members, and posted on the Association's website, AADEJ.org. Each issue includes regular updates from the editorial team and AADEJ board, as well as feature articles on current issues in the field.

This is a combined issue for 2012, issue 1 and 2.

An Overview Of Avoidant Personality Disorder, Kristin Dehrkoop

All Graduate Theses, Dissertations, and Other Capstone Projects

Avoidant Personality Disorder presents very similarly to other disorders in the Diagnostic and Statistical Manual (DSM-IV). What separates Avoidant Personality Disorder (APD) to other disorders that present similarly?

Headway Emotional Health Services: A Parent Satisfaction Survey And Needs Assessment, Eowyn T. Gatlin

All Graduate Theses, Dissertations, and Other Capstone Projects

Headway Emotional Health Services seeks to transform lives and restore families by providing a variety of quality mental health services to children and families in the Twin Cities Metro Area. The Vision Program is a partnership between Headway and the Bloomington Public School system. The Vision Program serves K-12 students who qualify for level 3 Emotional and/or Behavioral Disability (EBD) services. All students are in a classroom at their mainstream school and receive daily support from the Vision Mental Health Specialist, a special education classroom teacher, and a paraprofessional. Many students are able to participate in some mainstream programing through …

Implementation Of Evidence-Based Practices In Opioid Substance Abuse Treatment, Elizabeth V. Keck

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this capstone project is to begin the implementation of evidence-based practices for opioid substance abuse population in the rural community of Owatonna, MN and the surrounding communities.

Needs Assessment Of Emergency Department Social Workers In Southwestern Minnesota In Relation To Emergency Department Expansion, Gina Marie Njugunah

All Graduate Theses, Dissertations, and Other Capstone Projects

Expansion of a hospital emergency department will affect the role of the emergency department social worker. This research project was conducted to assess the needs, concerns, and strengths of the social workers working in the emergency department of a regional medical center. The study included 13 participants who completed an on-line survey. Results showed that participants were concerned with the increase in patient volume as well as the possible increase in wait time for patients. Participants also expressed how concerns could be addressed. The most common solution was to track information about the cases, including wait times for patients, in …

Mental Health Inpatient Hospitalization And Smoking Cessation, Susan Warring

All Graduate Theses, Dissertations, and Other Capstone Projects

Forty- four percent of cigarettes purchased, are by persons with serious mental illness. This population dies approximately twenty- five years earlier than the general population. In 1993, American hospitals were mandated to become smokefree. At that time, psychiatric facilities requested variances amid concerns that their patients may present adverse behaviors due to nicotine withdrawal. Within the last five years, smoking bans have become more prevalent, resulting in many psychiatric facilities adhering to a no smoking policy. The Owatonna Mental Health Unit at the Owatonna hospital currently has a variance to allow smoking breaks for their mentally ill inpatients.

Research Questions: …

Survey Of Emergency Department Patients' Perceived Barriers To Accessing Services And Community Resource Utilization, Kelsey Ann Wilke

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this project is to describe the patients being served by Avera McKennan’s emergency department (ED) and to explore perceived barriers to accessing services and current community resource utilization in order to prevent further non-emergent visits.

Research Questions: 1) What are the demographic characteristics of emergency department patients that are referred to the emergency department social worker? 2) What are the perceived barriers that emergency department patient’s encounter when trying to access services and community resources?

Aligning Network Quality Goals: Mammography Metrics, Michael Sheinberg Md

Department of Obstetrics & Gynecology

No abstract provided.

Acute Hypotensive Transfusion Reaction: A Case Report, Waleed Shah, Elia S. Elia

Department of Anesthesiology Faculty Papers

Introduction:

Acute hypotensive transfusion reactions are characterized by an abrupt and early onset of hypotension. This is often severe and lacks other signs of symptoms associated with more common causes of hypotension or transfusion reactions. Once the transfusion is stopped, the hypotension rapidly resolves, usually without the need for therapy.

Case Report detailed in poster.

Teaching Statistical Research Methods To Graduate Students: Lessons Learned From Three Different Degree Programs, Ozgur Ekmekci, Adrienne Hancock, Susan S. Swayze

Clinical Research and Leadership Faculty Publications

This paper examines the challenge of teaching statistical research methods in three master’s degree programs at a private university based in Washington, DC. We, as three professors teaching at this university, discuss the way we employ innovative approaches to deal with this challenge. We ground our discussion within the theoretical framework of problem-based learning and adult learning principles. We provide brief descriptions of our research methods courses to demonstrate how an instructor can facilitate learning of new knowledge and applications in a content area often considered intimidating by students. We also highlight similarities across the three different courses we teach …

Increasing The Efficiency Of Medical Research With Dynamic Research Summaries For Researchers And Consumers, Perry W. Payne

Clinical Research and Leadership Faculty Publications

Literature reviews are usually the first step in conducting medical research projects.They often lead to the creation of a useful research question. However, this initialstep in medical research contains inefficiencies, which if removed, could speedup the research process and thereby enhance development of innovative healthrelated products. In addition, existing research article databases offer informationwhich is inaccessible to most lay consumers. This article proposes an alternativeapproach for allowing researchers to assess the state of research in a particulararea called “dynamic research summaries.” These summaries would offer a regularlyupdated narrative of existing research in any given area. They could increasethe speed at …

Perceived Partner Support In Pregnancy Predicts Lower Maternal And Infant Distress, Lynlee R. Tanner Stapleton, Christine Dunkel Schetter, Erika Westling, Christine Rini, Laura M. Glynn, Calvin J. Hobel, Curt A. Sandman

Psychology Faculty Articles and Research

Maternal postpartum emotional distress is quite common and can pose significant risk to mothers and infants. The current study investigated mothers' relationships with their partners during pregnancy and tested the hypotheses that perception of prenatal partner support is a significant predictor of changes in maternal emotional distress from midpregnancy to postpartum, and contributes to maternal ratings of infant distress to novelty. Using a prospective longitudinal design, 272 adult pregnant women were interviewed regarding their partner support, relationship satisfaction, and interpersonal security (attachment style and willingness to seek out support), and they completed standardized measures of prenatal symptoms of depression and …

Increasing Parity Is Associated With Cumulative Effects On Memory, Laura M. Glynn

Psychology Faculty Articles and Research

BACKGROUND: The purpose of this investigation was to determine if reproductive experience is associated with cumulative effects on human memory performance during pregnancy and if these effects persist into the postpartum period.

METHODS: Verbal recall memory performance was assessed in 254 women four times during pregnancy and at 3 months postpartum. The relation between parity and memory function was evaluated with hierarchical linear modeling and analysis of covariance (ANCOVA).

RESULTS: The data indicate that the previously documented adverse effects of pregnancy on memory performance are compounded with successive pregnancies. During gestation and postpartum, multiparity was associated with poorer memory function, …

A Complex Systems Science Perspective For Whole Systems Of Complementary And Alternative Medicine Research, Mary Koithan, Iris R. Bell, Kathryn Niemeyer, David Pincus

Psychology Faculty Articles and Research

Whole systems complementary and alternative medicine (WS-CAM) approaches share a basic worldview that embraces interconnectedness; emergent, non-linear outcomes to treatment that include both local and global changes in the human condition; a contextual view of human beings that are inseparable from and responsive to their environments; and interventions that are complex, synergistic, and interdependent. These fundamental beliefs and principles run counter to the assumptions of reductionism and conventional biomedical research methods that presuppose unidimensional simple causes and thus dismantle and individually test various interventions that comprise only single aspects of the WS-CAM system. This paper will demonstrate the superior fit …

Self-Organizing Biopsychosocial Dynamics And The Patient-Healer Relationship, David Pincus

Psychology Faculty Articles and Research

The patient-healer relationship has an increasing area of interest for complementary and alternative medicine (CAM) researchers. This focus on the interpersonal context of treatment is not surprising as dismantling studies, clinical trials and other linear research designs continually point toward the critical role of context and the broadband biopsychosocial nature of therapeutic responses to CAM. Unfortunately, the same traditional research models and methods that fail to find simple and specific treatment-outcome relations are similarly failing to find simple and specific mechanisms to explain how interpersonal processes influence patient outcomes. This paper presents an overview of some of the key models …

In Vitro Antimicrobial Effect Of A Cold Plasma Jet Against Enterococcus Faecalis Biofilms, Chunqi Jiang, Christoph Schaudinn, David E. Jaramillo, Paul Webster, J. William Costerton

Bioelectrics Publications

The hypothesis that a cold plasma jet has the antimicrobial effect against Enterococcus faecalis biofilms was tested in vitro. 27 hydroxyapatite discs were incubated with E. faecalis for six days to form a monoculture biofilm on the disc surface. The prepared substrata were divided into three groups: the negative control, the positive control (5.25% NaOCl solution), and the plasma treatment group. Resultant colony-forming unit counts were associated with observations of bacterial cell morphology changes using scanning electron microscopy (SEM). Treatment of E. faecalis biofilm with the plasma and 5.25% NaOCl for 5min resulted in 93.1% and 90.0% kill (P < 0.0001), respectively. SEM detected that nearly no intact bacteria were discernible for the plasmaexposed HA disc surfaces. The demonstrated bactericidal effect of the plasma with direct surface contact may be due to the enhanced oxidation by the locally produced reactive plasma species.

Spina Bifida Subtypes And Sub-Phenotypes By Maternal Race/Ethnicity In The National Birth Defects Prevention Study, A J Agopian, Mark A Canfield, Richard S Olney, Philip J Lupo, Tunu Ramadhani, Laura E Mitchell, Gary M Shaw, Cynthia A Moore

Faculty, Staff and Student Publications

Spina bifida refers to a collection of neural tube defects, including myelomeningocele, meningocele, and myelocele (SB(M) ), as well as lipomyelomeningocele and lipomeningocele (SB(L) ). Maternal race/ethnicity has been associated with an increased risk for spina bifida among offspring. to better understand this relationship, we evaluated different spina bifida subtypes (SB(M) vs. SB(L) ) and sub-phenotypes (anatomic level or presence of additional malformations) by maternal race/ethnicity using data from the National Birth Defects Prevention Study. This study is a large, multisite, population-based study of nonsyndromic birth defects. Prevalence estimates were obtained using data from spina bifida cases (live births, fetal …

Horizontal Violence And The Quality And Safety Of Patient Care: A Conceptual Model, Christina Purpora, Mary A. Blegen

Nursing and Health Professions Faculty Research and Publications

For many years, nurses in international clinical and academic settings have voiced concern about horizontal violence among nurses and its consequences. However, no known framework exists to guide research on the topic to explain these consequences. This paper presents a conceptual model that was developed from four theories to illustrate how the quality and safety of patient care could be affected by horizontal violence. Research is needed to validate the new model and to gather empirical evidence of the consequences of horizontal violence on which to base recommendations for future research, education, and practice.

Cervical Human Papillomavirus Infection Among Young Women Engaged In Sex Work In Phnom Penh, Cambodia: Prevalence, Genotypes, Risk Factors And Association With Hiv Infection, Marie-Claude Couture, Kimberly Page, Ellen S. Stein, Neth Sansothy, Keo Sichan, John Kaldor, Jennifer L. Evans, Lisa Maher, Joel Palefsky

Nursing and Health Professions Faculty Research and Publications

Background

Although cervical cancer is the leading cancer in Cambodia, most women receive no routine screening for cervical cancer and few treatment options exist. Moreover, nothing is known regarding the prevalence of cervical HPV or the genotypes present among women in the country. Young sexually active women, especially those with multiple sex partners are at highest risk of HPV infection. We examine the prevalence and genotypes of cervical HPV, as well as the associated risk factors among young women engaged in sex work in Phnom Penh, Cambodia.

Methods

We conducted a cross-sectional study among 220 young women (15–29 years) engaged …

Distress During The Menopause Transition: A Rich Contextual Analysis Of Midlife Women's Narratives, Marcianna Nosek, Holly Powell Kennedy, Maria Gudmundsdottir

Nursing and Health Professions Faculty Research and Publications

In 2010, nearly 400 million women worldwide were of menopause age (45-54). Although many women transition through menopause with ease, some experience distress and a subsequent decrease in quality of life. The purpose of this qualitative study was to examine the experiences of distress in women during the menopause transition. A narrative analysis methodology was used maintaining participants’ complete narratives when possible. In-person interviews of 15 midlife women were digitally audio recorded and transcribed verbatim. Women shared narratives of distress related to menstrual changes, emotional instability, vaginal dryness, and decreased libido affected by their relationships with self, partners, work, and …