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2012

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Articles 481 - 510 of 7308

Full-Text Articles in Medicine and Health Sciences

Further Information: Monitoring And Protecting Groundwater During Oil And Gas Development, University Of Colorado Boulder. Natural Resources Law Center. Intermountain Oil And Gas Bmp Project, Colorado Water And Energy Research Center Nov 2012

Further Information: Monitoring And Protecting Groundwater During Oil And Gas Development, University Of Colorado Boulder. Natural Resources Law Center. Intermountain Oil And Gas Bmp Project, Colorado Water And Energy Research Center

Monitoring and Protecting Groundwater During Oil and Gas Development (November 26)

1 page.

"For Further Information" (URLs):

COGCC

Rules and Proposed Rules from Other Jurisdictions

Sampling Protocols

Impacts


Slides: Overview Of Colorado Aquifer Systems, Christopher J. Sanchez Nov 2012

Slides: Overview Of Colorado Aquifer Systems, Christopher J. Sanchez

Monitoring and Protecting Groundwater During Oil and Gas Development (November 26)

Presenter: Christopher J. Sanchez, P.G., BBA Water Consultants, Bishop-Brogden Associates, Inc.

28 slides


Slides: The Role Of Groundwater Sampling/Monitoring: Cogcc Proposed Rule 609, Gene Florentino Nov 2012

Slides: The Role Of Groundwater Sampling/Monitoring: Cogcc Proposed Rule 609, Gene Florentino

Monitoring and Protecting Groundwater During Oil and Gas Development (November 26)

Presenter: Gene Florentino, PG, Walsh Environmental Scientists and Engineers

14 slides


Slides: Colorado’S Groundwater Protection Program, Andrew Ross Nov 2012

Slides: Colorado’S Groundwater Protection Program, Andrew Ross

Monitoring and Protecting Groundwater During Oil and Gas Development (November 26)

Presenter: Andrew Ross, Colorado Department of Public Health and Environment

22 slides


Slides: Research On Ground Water Monitoring, Matt Samelson Nov 2012

Slides: Research On Ground Water Monitoring, Matt Samelson

Monitoring and Protecting Groundwater During Oil and Gas Development (November 26)

Presenter: Matt Samelson, Natural Resources Law Center and the Donnell-Kay Foundation

12 slides


Slides: Proposed Statewide Baseline Groundwater Sampling And Monitoring Rules, University Of Colorado Boulder. Natural Resources Law Center, Colorado. Oil And Gas Conservation Commission Nov 2012

Slides: Proposed Statewide Baseline Groundwater Sampling And Monitoring Rules, University Of Colorado Boulder. Natural Resources Law Center, Colorado. Oil And Gas Conservation Commission

Monitoring and Protecting Groundwater During Oil and Gas Development (November 26)

Presenter: Kathryn Mutz, Natural Resources Law Center, University of Colorado Law School

16 slides


Pilot Evaluation Of The Text4baby Mobile Health Program, William D. Evans, Jasmine L. Wallace, Jeremy Snider Nov 2012

Pilot Evaluation Of The Text4baby Mobile Health Program, William D. Evans, Jasmine L. Wallace, Jeremy Snider

Prevention and Community Health Faculty Publications

Background

Mobile phone technologies for health promotion and disease prevention have evolved rapidly, but few studies have tested the efficacy of mobile health in full-fledged programs. Text4baby is an example of mobile health based on behavioral theory, and it delivers text messages to traditionally underserved pregnant women and new mothers to change their health, health care beliefs, practices, and behaviors in order to improve clinical outcomes. The purpose of this pilot evaluation study is to assess the efficacy of this text messaging campaign.

Methods

We conducted a randomized pilot evaluation study. All participants were pregnant women first presenting for care …


Rorα, A Potential Tumor Suppressor And Therapeutic Target Of Breast Cancer, Jun Du, Ren Xu Nov 2012

Rorα, A Potential Tumor Suppressor And Therapeutic Target Of Breast Cancer, Jun Du, Ren Xu

Markey Cancer Center Faculty Publications

The function of the nuclear receptor (NR) in breast cancer progression has been investigated for decades. The majority of the nuclear receptors have well characterized natural ligands, but a few of them are orphan receptors for which no ligand has been identified. RORα, one member of the retinoid orphan nuclear receptor (ROR) subfamily of orphan receptors, regulates various cellular and pathological activities. RORα is commonly down-regulated and/or hypoactivated in breast cancer compared to normal mammary tissue. Expression of RORα suppresses malignant phenotypes in breast cancer cells, in vitro and in vivo. Activity of RORα can be categorized into the …


Medical School Watercooler Newsletter - November 25, 2012, Lindsey Lyle Nov 2012

Medical School Watercooler Newsletter - November 25, 2012, Lindsey Lyle

Watercooler Newsletter

This is the November 25 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

  • Snapshots: Sandy Worley Dedication Ceremony
  • USA College of Medicine Graduate Featured on National Television Show
  • Eran and N.Q. Adams Neurology Scholarship: Now Accepting Proposals
  • This Week's DSS - Dr. Steven Segal


Determinan Keluhan Muskuloskeletal Pada Tenaga Kerja Wanita, Andi Zulkifli Abdullah, A. Arsunan Arsin, Muhammad Yahya Nov 2012

Determinan Keluhan Muskuloskeletal Pada Tenaga Kerja Wanita, Andi Zulkifli Abdullah, A. Arsunan Arsin, Muhammad Yahya

Kesmas

Insomnia merupakan gangguan tidur yang paling sering ditemukan pada lanjut usia (lansia) dengan prevalensi sekitar 67%. Penelitian ini bertujuan untuk menilai hubungan antara kecemasan, depresi, dukungan keluarga, dan kondisi lingkungan dengan kejadian insomnia pada lansia di Panti Sosial Tresna Werdha Gau Mabaji Kabupaten Gowa. Penelitian ini menggunakan desain studi observasional dengan rancangan cross sectional dan metode exhausive sampling. Data dianalisis dengan uji chi square, koefisien phi (f) dengan a = 0,05. Sebanyak 96 lansia penghuni panti memenuhi kriteria penelitian. Uji chi square menunjukkan bahwa terdapat hubungan antara kecemasan (nilai p = 0,014; f = 0,251), depresi (nilai p = 0,019; …


Reservoir Dan Kasus Leptospirosis Di Wilayah Kejadian Luar Biasa, Tri Ramadhani, Bambang Yunianto Nov 2012

Reservoir Dan Kasus Leptospirosis Di Wilayah Kejadian Luar Biasa, Tri Ramadhani, Bambang Yunianto

Kesmas

Kabupaten Kulonprogo adalah salah satu daerah dengan masalah leptospirosis penyakit zoonosis yang dapat menginfeksi spesies hewan dan manusia. Studi ini bertujuan untuk mengetahui reservoir dan distribusi kasus leptospirosis pascakejadian luar biasa di Kabupaten Kulonprogo. Metode yang digunakan adalah inkriminasi bakteri Leptospira sp. pada tikus dan penegakan diagnosis pada manusia dengan rapid test dan MAT. Sumber data yang digunakan adalah data sekunder dan data primer dengan melakukan screening di Rumah Sakit dan Puskesmas. Penelitian observasional ini menggunakan rancangan studi cross sectional dengan metode analisis data secara distribusi frekuensi dalam bentuk gambar, grafik, dan tabel. Penelitian menemukan jumlah penderita leptospirosis di Kabupaten …


Determinan Insomnia Pada Lanjut Usia, Iwan Muhamad Ramdan, Tiyanpri Bayu Laksmono Nov 2012

Determinan Insomnia Pada Lanjut Usia, Iwan Muhamad Ramdan, Tiyanpri Bayu Laksmono

Kesmas

Gangguan muskuloskeletal merupakan masalah kesehatan dan keselamatan kerja yang penting karena masih berkontribusi pada penurunan produktivitas kerja. Penelitian ini bertujuan untuk mengetahui hubungan umur tenaga kerja, masa kerja, indeks massa tubuh, dan sikap kerja dengan keluhan gangguan muskuloskeletal pada tenaga kerja wanita di unit produksi bagian kupas di PT SSM Kalimantan Timur. Penelitian kuantitatif yang menggunakan desain penelitian cross sectional ini dilakukan pada tenaga kerja wanita bagian pengupasan yang berjumlah 46 orang (total sampling). Variabel bebas penelitian terdiri dari umur, masa kerja, indeks massa tubuh, dan posisi kerja, sementara variabel terikat adalah keluhan gangguan muskuloskeletal. Analisis data yang digunakan adalah …


Analisis Risiko Pajanan Pm2,5 Di Udara Ambien Siang Hari Terhadap Masyarakat Di Kawasan Industri Semen, Randy Novirsa, Umar Fahmi Achmadi Nov 2012

Analisis Risiko Pajanan Pm2,5 Di Udara Ambien Siang Hari Terhadap Masyarakat Di Kawasan Industri Semen, Randy Novirsa, Umar Fahmi Achmadi

Kesmas

Salah satu dampak negatif industri pabrik semen terhadap kesehatan masyarakat adalah peningkatan risiko penyakit saluran pernapasan. Risiko tersebut banyak disebabkan oleh pajanan partikulat di udara, khususnya partikulat berukuran di bawah 2,5 mikron (PM2,5). Penelitian ini bertujuan menganalisis risiko pajanan PM2,5 di udara ambien siang hari pada masyarakat di kawasan industri semen. Risiko dihitung dengan metode Analisis Risiko Kesehatan Lingkungan berdasarkan metode Louvar yang menghasilkan nilai Intake pajanan yang diterima individu per hari berdasarkan nilai konsentrasi pajanan, pola aktivitas individu, dan nilai antropometri. Konsentrasi PM2,5 di lingkungan diukur pada 10 titik dengan radius 500 meter antartitik dari pusat pabrik, sedangkan pola …


Perilaku Seks Pranikah Remaja, Komang Yuni Rahyani, Adi Utarini, Siswanto Agus Wilopo, Mohammad Hakimi Nov 2012

Perilaku Seks Pranikah Remaja, Komang Yuni Rahyani, Adi Utarini, Siswanto Agus Wilopo, Mohammad Hakimi

Kesmas

Hubungan seksual sebelum nikah pada remaja merupakan masalah yang serius, berhubungan dengan peningkatan penularan penyakit menular seksual, mempunyai pasangan lebih dari satu, dan kehamilan dini. Suatu kerangka kerja model perilaku terintegrasi (Integrated Behavioral Model, IBM) digunakan untuk menilai berbagai faktor prediktor hubungan seksual prematur pada remaja. Tujuan penelitian ini adalah mengeksplorasi inisiasi hubungan seksual sebelum nikah pada remaja level 10 dan 11 berdasarkan kerangka kerja IBM, meliputi komunikasi tentang seks kelompok peers, orang tua, paparan perilaku pornografi, kepercayaan normatif, agen personal, dan keinginan hubungan seksual. Metode yang digunakan adalah menyertakan 626 responden dalam survei awal. Responden adalah siswa sekolah menengah …


Model Pemberdayaan Masyarakat Bidang Kesehatan, Studi Program Desa Siaga, Endang Sutisna Sulaeman, Ravik Karsidi, Bhisma Murti, Drajat Tri Kartono, Waryana Waryana, Rifai Hartanto Nov 2012

Model Pemberdayaan Masyarakat Bidang Kesehatan, Studi Program Desa Siaga, Endang Sutisna Sulaeman, Ravik Karsidi, Bhisma Murti, Drajat Tri Kartono, Waryana Waryana, Rifai Hartanto

Kesmas

Sejak tahun 2006, Departemen Kesehatan meluncurkan kebijakan program Desa Siaga. Tampaknya, kebijakan tersebut tidak mampu memberdayakan masyarakat dalam mengidentifikasi dan memecahkan masalah kesehatan pada level komunitas (desa). Penelitian ini bertujuan merumuskan model pemberdayaan masyarakat bidang kesehatan pada program Desa Siaga. Sasaran penelitian adalah Forum Kesehatan Desa dan Pos Kesehatan Desa Siaga di 30 desa di Kabupaten Karanganyar, Jawa Tengah. Metode yang digunakan dalam penelitian ini adalah survei dan studi kasus. Hasil penelitian menunjukkan faktor-faktor yang berhubungan dengan kemampuan masyarakat dalam mengidentifikasi masalah kesehatan dan kemampuan masyarakat dalam memecahkan masalah kesehatan. Model pemberdayaan masyarakat bidang kesehatan meliputi kemampuan mengidentifikasi dan memecahkan …


Allogeneic Stem Cell Transplantation In Acute Myeloid Leukemia, Natasha Bahadur Ali, Salman Adil, Mohammad Usman Shaikh, Nehal Masood Nov 2012

Allogeneic Stem Cell Transplantation In Acute Myeloid Leukemia, Natasha Bahadur Ali, Salman Adil, Mohammad Usman Shaikh, Nehal Masood

Department of Pathology and Laboratory Medicine

We report a case series of 12 patients with acute myeloid leukemia who underwent allogeneic stem cell transplant with a matched related donor. Male to female ratio was 1:1. The main complication post-transplant was graft-versus-host disease (n=7 patients). Transplant-related mortality involved one patient; cause of death was multi-organ failure. After a median follow up of 36.0±11.3 months, overall survival was 16%.


Over Prescription Of Antibiotics For Adult Pharyngitis Is Prevalent In Developing Countries But Can Be Reduced Using Mcisaac Modification Of Centor Scores: A Cross-Sectional Study., Amber Hanif Palla, Rafeeq Alam Khan, Anwar H. Gilani, Fawziah Marra Nov 2012

Over Prescription Of Antibiotics For Adult Pharyngitis Is Prevalent In Developing Countries But Can Be Reduced Using Mcisaac Modification Of Centor Scores: A Cross-Sectional Study., Amber Hanif Palla, Rafeeq Alam Khan, Anwar H. Gilani, Fawziah Marra

Department of Biological & Biomedical Sciences

Background

Although Group A beta hemolytic streptococcus (GABHS) can cause bacterial pharyngitis, the most common etiology is viral; despite this viral etiology, antibiotics are commonly prescribed for this infection in industrialized countries. We investigated the prevalence of GABHS in adult pharyngitis patients from lower socioeconomic settings in Karachi, Pakistan, how often antibiotics are prescribed for pharyngitis and if appropriate agents were used in a developing world setting. Finally, we wanted to see the usefulness of modified McIsaac scores in predicting positive cultures.

Methods

Adult patients were recruited from three local hospital outpatient dispensaries (OPDs). All patients aged 14–65 years who …


Art In Occupational Therapy: An Introduction To Occupation And The Artist, Molly Bathje Nov 2012

Art In Occupational Therapy: An Introduction To Occupation And The Artist, Molly Bathje

The Open Journal of Occupational Therapy

No abstract provided.


Diagnostic Statistical Manual 5 Changes To The Autism Diagnostic Criteria: A Critical Moment For Occupational Therapists, Rondalyn Varney Whitney, Heather Miller-Kuhaneck Nov 2012

Diagnostic Statistical Manual 5 Changes To The Autism Diagnostic Criteria: A Critical Moment For Occupational Therapists, Rondalyn Varney Whitney, Heather Miller-Kuhaneck

The Open Journal of Occupational Therapy

Changes in the soon to be released Diagnostic Statistical Manual (DSM) – 5 (American Psychiatric Association, 2012) bring new opportunities for occupational therapy, but the profession must prepare for the impact these changes forecast. While well positioned to capitalize on newly defined specifications of Autism Spectrum Disorders (ASD) and the elevation of sensory processing difficulties to a core feature of the disorder, the profession must be alert to the potential downside of the pending changes. The more stringent diagnostic rubric will likely exclude a significant number of individuals currently eligible for therapeutic and academic services. Autism will be defined as …


Ot-Pep: Development Of A Professional Education Paradigm For Occupational Therapy, Christine E. Wright Nov 2012

Ot-Pep: Development Of A Professional Education Paradigm For Occupational Therapy, Christine E. Wright

The Open Journal of Occupational Therapy

This study aims to determine the fundamental tenets that define the occupational therapy education process, and to develop a professional education paradigm that corresponds to those principles. Interpretive phenomenology with Heideggerian hermeneutic philosophy was used to explicate the paradigmatic themes embedded in the occupational therapy body of knowledge. The results yielded the Occupational Therapy Professional Education Paradigm (OT-PEP), which is organized around three core concepts: Adaptive thinking, reflection, and creation of meaning. The OT-PEP is important to occupational therapy because it addresses the elements of the education process that are reflective of the philosophical underpinnings of the profession and brings …


Examining The Sensory Profiles Of At-Risk Youth Participating In A Pre-Employment Program, Chi-Kwan Shea, Robyn Wu Nov 2012

Examining The Sensory Profiles Of At-Risk Youth Participating In A Pre-Employment Program, Chi-Kwan Shea, Robyn Wu

The Open Journal of Occupational Therapy

The purpose of this study is to use Dunn’s model of sensory processing to investigate the sensory profiles of youth participating in a community-based occupational therapy pre-employment program. The youth participants had been involved in the juvenile justice system and were placed on probation. The study analyzed data from the Adolescent/Adult Sensory Profile (AASP) questionnaires (Brown & Dunn, 2002) completed by 79 youth participants. Analysis of the participants’ scores on the AASP showed statistically significant differences from the norm in two quadrants; the delinquent youth scored lower in Sensation Seeking and higher in Sensation Avoiding. The delinquent youth participants demonstrated …


Enhancing Social Skills In Adolescents With High Functioning Autism Using Motor-Based Role-Play Intervention, Sharon A. Gutman, Emily I. Raphael-Greenfield, Neal Carlson, Rachel Friedman, Amanda Iger Nov 2012

Enhancing Social Skills In Adolescents With High Functioning Autism Using Motor-Based Role-Play Intervention, Sharon A. Gutman, Emily I. Raphael-Greenfield, Neal Carlson, Rachel Friedman, Amanda Iger

The Open Journal of Occupational Therapy

The purpose of this pilot study was to collect pilot data evaluating whether a motor-based role-play intervention using a canine animal assistant can enhance social skill use in two adolescents with HFA. A single subject ABA design across two participants was used. The intervention consisted of four 1-hour sessions over 4 weeks. The quality of social interaction was measured by the Evaluation of Social Interaction (ESI) administered at baseline and the 3-month probe. Frequency of targeted social skill use was measured during baseline, intervention, and probe phases. Participant 1 experienced statistically significant increases in both ESI scores (p = …


The Effects Of A Summer Camp Experience On Factors Of Resilience In At-Risk Youth, Marybeth Merryman, Amanda Mezei, Jill A. Bush, Marcie Weinstein Nov 2012

The Effects Of A Summer Camp Experience On Factors Of Resilience In At-Risk Youth, Marybeth Merryman, Amanda Mezei, Jill A. Bush, Marcie Weinstein

The Open Journal of Occupational Therapy

This pilot study addressed the impact of a summer camp experience on at-risk middle school youth by exploring self-reported growth in skill development and resilience. Campers who attended a five-week summer day camp were compared to a control group who maintained typical activities throughout the summer. Results showed statistically significant differences in the campers’ belief of a good future for themselves (U = 179.40, P = 0.05). Campers reported sustained or positive growth in domains of social skills and positive values from the baseline to a six-month follow up. Three significant themes emerged from individual in-depth interviews including: (a) engagement …


Associations Of Physiological Factors, Age, And Sensory Over-Responsivity With Food Selectivity In Children With Autism Spectrum Disorders, Michelle A. Suarez, Nickola W. Nelson, Amy B. Curtis Nov 2012

Associations Of Physiological Factors, Age, And Sensory Over-Responsivity With Food Selectivity In Children With Autism Spectrum Disorders, Michelle A. Suarez, Nickola W. Nelson, Amy B. Curtis

The Open Journal of Occupational Therapy

PURPOSE: The aim of this study was to investigate the relationship among physiological factors, age, sensory over-responsivity (SOR) and food selectivity in children with autism spectrum disorders (ASD).

METHODS: One hundred forty-one parents of children with ASD were recruited through a national autism organization, Autism Speaks, to fill out a survey regarding their child’s mealtime behavior. Survey contained items to measure the severity of food selectivity behavior, the presence of physiological factors (i.e., reflux, constipation, food allergies and the need for a specialized diet) and sensory over-responsivity (SOR). Results were analyzed using Chi Square, ANOVA and logistic regression.

RESULTS: No …


Letter From The Editor: Welcome To Ojot!, Diane Powers Dirette Nov 2012

Letter From The Editor: Welcome To Ojot!, Diane Powers Dirette

The Open Journal of Occupational Therapy

No abstract provided.


Transfusion Of Cxcr4-Primed Endothelial Progenitor Cells Reduces Cerebral Ischemic Damage And Promotes Repair In Db/Db Diabetic Mice, Ji Chen, Jianying Chen, Shuzhen Chen, Cheng Zhang, Liangqing Zhang, Xiang Xiao, Avik Das, Yuhui Zhao, Bin Yuan, Mariana Morris, Bin Zhao, Yanfang Chen Nov 2012

Transfusion Of Cxcr4-Primed Endothelial Progenitor Cells Reduces Cerebral Ischemic Damage And Promotes Repair In Db/Db Diabetic Mice, Ji Chen, Jianying Chen, Shuzhen Chen, Cheng Zhang, Liangqing Zhang, Xiang Xiao, Avik Das, Yuhui Zhao, Bin Yuan, Mariana Morris, Bin Zhao, Yanfang Chen

Pharmacology and Toxicology Faculty Publications

This study investigated the role of stromal cell-derived factor-1α (SDF-1α)/CXC chemokine receptor 4 (CXCR4) axis in brain and endothelial progenitor cells (EPCs), and explored the efficacy of CXCR4 primed EPCs in treating ischemic stroke in diabetes. The db/db diabetic and db/+ mice were used in this study. Levels of plasma SDF-1α and circulating CD34+CXCR4+ cells were measured. Brain SDF-1α and CXCR4 expression were quantified at basal and after middle cerebral artery occlusion (MCAO). In in vitro study, EPCs were transfected with adenovirus carrying null (Ad-null) or CXCR4 (Ad-CXCR4) followed with high glucose (HG) treatment for 4 days. For pathway block …


Strike Mechanics Of An Ambush Predator: The Spearing Mantis Shrimp, M. Devries, E. Murphy, S. Patek Nov 2012

Strike Mechanics Of An Ambush Predator: The Spearing Mantis Shrimp, M. Devries, E. Murphy, S. Patek

Faculty Publications, Biological Sciences

Ambush predation is characterized by an animal scanning the environment from a concealed position and then rapidly executing a surprise attack. Mantis shrimp (Stomatopoda) consist of both ambush predators (‘spearers’) and foragers (‘smashers’). Spearers hide in sandy burrows and capture evasive prey, whereas smashers search for prey away from their burrows and typically hammer hard-shelled, sedentary prey. Here, we examined the kinematics, morphology and field behavior of spearing mantis shrimp and compared them with previously studied smashers. Using two species with dramatically different adult sizes, we found that strikes produced by the diminutive species, Alachosquilla vicina, were faster (mean peak …


'Everything I Love Is Illegal, Immoral Or Against The Advice Of The Surgeon General', Roberto Hugh Potter Nov 2012

'Everything I Love Is Illegal, Immoral Or Against The Advice Of The Surgeon General', Roberto Hugh Potter

UCF Forum

The recent situation of TV anchor Jennifer Livingston in La Crosse, Wisc., offers a glimpse into how external indicators of health are becoming stigmatized in the public-health efforts to battle the “epidemic of obesity.”


Today - November 21, 2012, Loma Linda University Nov 2012

Today - November 21, 2012, Loma Linda University

TODAY

Inside this issue:

-- Seeds of Hope event raises more than $119,000 in support of services provided by LLU Behavioral Medical Center
-- School of Pharmacy welcomes new students with ceremony
-- Domestic Violence and Sexual Assault Task Force reaches out to students
-- Public health alumni gather national conference
-- Medical Center named 2012-2013 Consumer Choice Award winner
-- Grant will help save babies from nicotine
-- LLU professor teaches course on desert snakes at Joshua Tree National Park
-- Spiritual life & wholeness leadership banquet honors 55 employees
-- Tenth annual Senior Wellness and Fitness Fair jointly held …


Joint Effect Of Genetic And Lifestyle Risk Factors On Type 2 Diabetes Risk Among Chinese Men And Women, Raquel Villegas, Ryan Delahanty, Yu-Tang Gao, Jirong Long, Scott M. Williams, Yong-Bing Xiang, Hui Cai, Hong-Lan Li, Frank Hu, Qiuyin Cai, Wei Zheng, Xiao-Ou Shu Nov 2012

Joint Effect Of Genetic And Lifestyle Risk Factors On Type 2 Diabetes Risk Among Chinese Men And Women, Raquel Villegas, Ryan Delahanty, Yu-Tang Gao, Jirong Long, Scott M. Williams, Yong-Bing Xiang, Hui Cai, Hong-Lan Li, Frank Hu, Qiuyin Cai, Wei Zheng, Xiao-Ou Shu

Dartmouth Scholarship

More than 40 genetic susceptibility loci have been reported for type 2 diabetes (T2D). Recently, the combined effect of genetic variants has been investigated by calculating a genetic risk score. We evaluated 36 genome-wide association study (GWAS) identified SNPs in 2,679 T2D cases and 3322 controls in middle-age Han Chinese. Fourteen SNPs were significantly associated with T2D in analysis adjusted for age, sex and BMI. We calculated two genetic risk scores (GRS) (GRS1 with all the 36 SNPs and GRS2 with the 14 SNPs significantly associated with T2D). The odds ratio for T2D with each GRS point (per risk allele) …