Medicine and Health Sciences Commons^™

Motor Neuron Apoptosis And Neuromuscular Junction Perturbation Are Prominent Features In A Drosophila Model Of Fus-Mediated Als, Ruohan Xia, Yajuan Liu, Liuqing Yang, Jozsef Gal, Haining Zhu, Jianhang Jia

Markey Cancer Center Faculty Publications

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is progressive neurodegenerative disease characterized by the loss of motor function. Several ALS genes have been identified as their mutations can lead to familial ALS, including the recently reported RNA-binding protein fused in sarcoma (Fus). However, it is not clear how mutations of Fus lead to motor neuron degeneration in ALS. In this study, we present a Drosophila model to examine the toxicity of Fus, its Drosophila orthologue Cabeza (Caz), and the ALS-related Fus mutants.

RESULTS: Our results show that the expression of wild-type Fus/Caz or FusR521G induced progressive toxicity in multiple tissues of the …

Substance Abuse Treatment Stage And Personal Networks Of Women In Substance Abuse Treatment, Elizabeth M. Tracy, Hyunsoo Kim, Suzanne Brown, Meeyoung Oh Min, Min Kyoung Jun, Christopher Mccarty

Social Work Faculty Publications

This study examines the relationship among 4 treatment stages (i.e., engagement, persuasion, active treatment, relapse prevention) and the composition, social support, and structural characteristics of personal networks. The study sample includes 242 women diagnosed with substance dependence who were interviewed within their first month of intensive outpatient treatment. Using EgoNet software, the women reported on their 25 alter personal networks and the characteristics of each alter. With one exception, few differences were found in the network compositions at different stages of substance abuse treatment. The exception was the network composition of women in the active treatment stage, which included more …

Vitamin D Levels In Asymptomatic Adults--A Population Survey In Karachi, Pakistan, Adil Sheikh, Zeb Saeed, Syed Ali Danial Jafri, Iffat Yazdani, Syed Ather Hussain

Section of Nephrology

Background: It is well established that low levels of 25(OH) Vitamin D (/dL) are a common finding world over, affecting over a billion of the global population. Our primary objective was to determine the prevalence of vitamin D deficiency and insufficiency in the asymptomatic adult population of Karachi, Pakistan and the demographic, nutritional and co-morbidity characteristics associated with serum vitamin D levels. Methods: A cross-sectional population survey was conducted at two spaced out densely populated areas of the city. Serum levels of 25OH vitamin D were measured and GFR as renal function was assessed by using 4 variable MDRD formula. …

Reactive Oxygen Species And Mitochondrial Sensitivity To Oxidative Stress Determine Induction Of Cancer Cell Death By P21, Ionica Masgras, Samantha Carrera, Petra J. De Verdier, Paul Brennan, Aneela Majid, Wan Makhtar, Eugene Tulchinsky, George D. Jones, Igor Roninson, Salvador Macip

Faculty Publications

p21(Waf1/Cip1/Sdi1) is a cyclin-dependent kinase inhibitor that mediates cell cycle arrest. Prolonged p21 up-regulation induces a senescent phenotype in normal and cancer cells, accompanied by an increase in intracellular reactive oxygen species (ROS). However, it has been shown recently that p21 expression can also lead to cell death in certain models. The mechanisms involved in this process are not fully understood. Here, we describe an induction of apoptosis by p21 in sarcoma cell lines that is p53-independent and can be ameliorated with antioxidants. Similar levels of p21 and ROS caused senescence in the absence of significant death in other cancer …

Comparison Of Visual Vs. Microscopic Methods To Detect Blood Splatter From An Intravascular Catheter With Engineered Sharps Injury Protection (Esip), Aiysha R. Ansari

USF Tampa Graduate Theses and Dissertations

Intravascular devices with engineered sharps injury protection (ESIP) are designed to reduce sharps injuries, but have not been investigated for blood splatter potential. In this laboratory-based experiment, which did not use human subjects, 100 intravenous catheters of the same type with a retraction mechanism, were tested for blood splatter. Once blood was obtained from a simulated brachial vein containing mock venous blood, the devices were placed in a testing chamber and scientific filters labeled A, B & C were used to capture blood splatter after activation. The blood splatter was examined visually and microscopically, and the filters were weighed pre- …

"You Have To Have Children To Be Happy:" Exploring Beliefs About Reproduction With Burmese Refugee Women In The United States, Kara E. Mcginnis

USF Tampa Graduate Theses and Dissertations

Burmese refugees are entering the US at record speed. Resettlement agencies focus on immediate needs, and ethnic community-based organizations (ECBOs) fill any service gaps through community-driven programs. The Tampa Bay Burmese Council (TBBC) is an ECBO in Tampa, FL dedicated to the Burmese community. This research explores the reproductive beliefs of the women in the community, paying particular attention to any differences that arise due to beliefs specific to their ethnic group. Findings include the importance of menses for women's health, the preference for both male and female children, a lack of knowledge about family planning methods, a tendency to …

Development Of A Tool For Pressure Ulcer Risk Assessment And Preventive Interventions In Ancillary Services Patients, Monica Shutts Messer

USF Tampa Graduate Theses and Dissertations

The incidence of nosocomial pressure ulcers has continued to increase in U.S. hospitals over the past 15 years despite the implementation of national preventive guidelines and the wide-spread use of validated risk assessment tools. The majority of preventive efforts and tools have been focused primarily on patients who are bed-ridden or immobile for extended periods. What has not been well studied or identified is the potential risk for pressure injury to patients undergoing diagnostic procedures in hospital ancillary units where extrinsic risk factors such as high interface pressures on procedure tables and friction and shear from positioning and transport can …

Financial Position And Adoption Of Electronic Health Records: A Retrospective Longitudinal Study, Jay J. Shen, Gregory O. Ginn

School of Public Health Faculty Research

AIM: Financial barriers are a major factor of slow electronic health record (EHR) adoption among US hospitals. All existing literature focuses on relationships between current or short-term financial position and EHR adoption. This study examines relationship between financial position in previous years and the current level of EHR adoption.

METHODS: Retrospective longitudinal data were extracted from (1) the 2009 American Hospital Association (AHA) EHR implementation survey; (2) the 2002 and 2006 Centers for Medicare & Medicaid Cost Reports; and (3) the 2002 and 2006 AHA Annual Survey containing organizational and operational data. The final sample was 2,701 acute care hospitals …

Coronary Artery Bypass Grafting: Quality Of Life Of Patients In Karachi, Rozina Barolia, Fauziya Ali, Salma Jaffar

School of Nursing & Midwifery

In the Third World, cardiac Patients often suffer not only from the nature of their illnesses, but also the insufficiency of the facilities available. Although the effectiveness of coronary artery bypass grafting (CABG) is being evaluated in terms of mortality, complications or recurrence of symptoms, empirical studies assessing the change in Patients' quality of life (QOL) after CABG within the Pakistani cultural context are lacking.
Aims: The aims of the present study are to assess and compare the change in health-related quality of life before and 1 month after CABG and to assess the differences in QOL with respect to …

A Proposed Mediation Model Of The Effects Of Motivation For A Healthy Lifestyle: Impacts On Emotional Exhaustion, Medication Regimens, And Low-Density Lipoprotein, Nathan M. Leuthold

Theses and Dissertations

This research addressed the following question: "How are behavioral indicators related to physiological responses?" Three theories -- Conservation of Resources, Planned Behavior, and Achievement Motivation -- were employed to build a proposed model of the effects that an individual's motivation for a healthy lifestyle would have on his/her emotional exhaustion, daily medication usage, and low-density lipoproteins. Motivation for a healthy lifestyle was hypothesized to have a negative relationship with emotional exhaustion when using body mass index as a partial mediator. Emotional exhaustion was hypothesized to have positive relationships with daily medication usage and low-density lipoproteins. The model was tested using …

Understanding The Public Health Challenges In The Era Of Mass Incarceration. President Travis' Keynote Speech At The Fifth Annual Academic And Health Policy Conference On Correctional Health On March 22, 2012 In Atlanta, Ga., Jeremy Travis

Publications and Research

No abstract provided.

Probabilistic Model For Laser Damage To The Human Retina, David A. Wooddell Jr.

Theses and Dissertations

Understanding how lasers interact with media during propagation is a premiere field of physics. The subject area known as laser bioeffects explores laser interactions with biological cells, tissues, organs, and bodies. This research includes laser applications used in medicine, establishes safe exposure limits for industry and academia, and generally studies the many effects of laser light on living creatures. The bioeffects community relies heavily on deterministic modeling and simulation tools to support experimental research into damage thresholds and laser effects. However, recent laser applications require a probabilistic approach to support risk management and analyses methodologies. Some probabilistic models exist, but …

Comparative Analysis Of Two Biological Warfare Air Samplers Using Live Surrogate Agents, James C. Enderby

Theses and Dissertations

The United States Air Force has several high-volume biological air samplers, including the XMX/2L-MIL and the Biocapture 650. Limited information is available on either in terms of its collection of viruses and bacteria. However, previous research on the XMX/2L-MIL has determined that modifications to the secondary flow rate and the use of a virus preserving collection media may provide improved virus collection rates. In this thesis, these modifications were investigated to determine their impact on the collection of viral and bacterial aerosols. Additionally, relative collection rates were compared against those for the Biocapture 650. MS2 bacteriophage was the viral surrogate …

Influence Of Ph On The Transport Of Silver Nanoparticles In Saturated Porous Media: Laboratory Experiments And Modeling, Jason R. Flory

Theses and Dissertations

Given the ubiquity of silver nanoparticles (AgNPs), the largest and fastest growing category of nanomaterials, and their potential for toxic effects to both humans and the environment, it is important to understand their environmental fate and transport. The purpose of this study is to gain information on the transport properties of unmodified AgNP suspensions in a glass bead-packed column under saturated flow conditions at different solution pH levels. Commercial AgNPs were characterized using high resolution transmission spectroscopy (HRTEM), dynamic light scattering (DLS) and ultraviolet (UV) visible spectroscopy. Transport data were collected at different pH levels (4, 6.5 and 9) at …

The Effects Of Cognitive-Behavioral Motivation For Health Improvement On Anthropometric Measurements In High Risk Individuals, Aimee T. Kirchner

Theses and Dissertations

Unhealthy lifestyles cost businesses, governmental organizations, and the United States military billions of dollars every year. To fight this rising cost as well as potentially save lives this study sought to understand if a cognitive-behavioral motivation treatment could positively affect the cognitive variables (attitude, self-efficacy, and locus of control) that induce long term behavior change. Anthropometric measurements, specifically body mass index, abdominal circumference, and abdominal height, were used to determine if long term behavior change resulted from the treatment. The Theory of Planned Behavior was the basis of this thesis' model, while the Valence, Instrumentality, and Expectancy (VIE) theory was …

Individual And Social Determinants Of Multiple Chronic Disease Behavioral Risk Factors Among Youth, Arsham Alamian, Gilles Paradis

ETSU Faculty Works

BACKGROUND: Behavioral risk factors are known to co-occur among youth, and to increase risks of chronic diseases morbidity and mortality later in life. However, little is known about determinants of multiple chronic disease behavioral risk factors, particularly among youth. Previous studies have been cross-sectional and carried out without a sound theoretical framework.

METHODS: Using longitudinal data (n = 1135) from Cycle 4 (2000-2001), Cycle 5 (2002-2003) and Cycle 6 (2004-2005) of the National Longitudinal Survey of Children and Youth, a nationally representative sample of Canadian children who are followed biennially, the present study examines the influence of a set of …

Testing A Model Of Bacterial Vaginosis Among Black Women, Jessica Brumley

USF Tampa Graduate Theses and Dissertations

Bacterial Vaginosis is an inbalance of vaginal flora which has been associated with increased risk of numerous gynecological and obstetric morbidities including increased risk of acquisition of HIV from an infected partner and increased risk of preterm delivery. Black race has been consistently identified as a risk factor for BV. Black women also suffer from significant disparities in most of the morbidities also associated with BV when compared to women of other ethnicities and races. Traditional predictors of BV such as douching practices and sexual behaviors do not fully account for the racial disparities in BV prevalence. Researchers have begun …

Instructions For Authors

Journal of Health Disparities Research and Practice

The Journal of Health Disparities Research and Practice (JHDRP) is an on-line journal that explores the problems and challenges of health disparities among the diverse populations of the United States. Our mission is to publish research that will guide the development of evidence based solutions, policy, and programs in an effort to reduce and ultimately eliminate health disparities. The JHDRP welcomes submissions of original papers from researchers, public health practitioners, and students researching and working on health disparities research, practice, policy, evaluation, and/or solutions. Questions about the suitability of a topic should be directed to the editor.

Breast Cancer Screening Practices Among American Indians And Alaska Natives In The Midwest, Christine M. Daley, Melissa Filippi, Aimee S. James, Sarah Brokenleg, Stacy Braiuca, K. A. Greiner, Won S. Choi

Journal of Health Disparities Research and Practice

American Indian and Alaska Native (AI/AN) women currently have some of the highest mortality rates from breast cancer for any racial/ethnic group in the United States and some of the lowest screening rates. However, current data are not available for regional differences in screening, which can result in dramatically different stage at diagnosis and mortality. We conducted surveys with 120 focus group participants in a needs assessment of mammography among AI/AN in the greater Kansas City metropolitan area and parts of Northeast Kansas. We found that among women under age 40, for whom recommended screenings include only annual clinical breast …

Race And Hepatitis C Management Within The Veterans Administration, Joahd Toure, Joshua Metlay, Sandford Schwartz, Knashawn Morales, David Kaplan, Peter Groeneveld

Journal of Health Disparities Research and Practice

Objective: To examine black-white differences in hepatitis C treatment within the Veterans Administration (VA) and determine whether racial variation in specialty consultation explains differences in hepatitis C treatment between blacks and whites.

Methods: We performed a retrospective cohort study of 1040 veterans meeting VA eligibility criteria for hepatitis C treatment. We used multiple imputation to handle missing race data. Specialty consultation was determined from the VA outpatient medical dataset and hepatitis C treatment was determined from the VA decision support system. Conditional logistic regression was used to examine the association between race and hepatitis C treatment as well as race …

Spiritual Care Within Oncology Care: Development Of A Spiritual Care Program At An Indian Health Service Hospital, Catherine Witte, Tamana D. Begay, Kathryn Coe

Journal of Health Disparities Research and Practice

Spiritual care is essential in providing quality health care for patients and their families and is supported in the mission of the Indian Health Service (IHS). Their mission is to raise the physical, mental, social and spiritual health of American Indians and Alaska Natives to the highest level. This paper will describe the spiritual care programs at the Phoenix Indian Medical Center, an IHS hospital located in Phoenix, Arizona. Two hospital committees, the Volunteer Chaplains’ Association and the Traditional Cultural Advocacy Committee, provide spiritual care for the medical center and work to sustain a presence of spiritual and cultural awareness …

Poverty And Mortality Disparities In Central Appalachia: Mountaintop Mining And Environmental Justice, Michael Hendryx

Journal of Health Disparities Research and Practice

Objectives. This study investigated the associations between poverty rates, Appalachian mountaintop coal mining, and age-adjusted total mortality rates to determine if persons exposed to this form of mining experience greater poverty and higher death rates compared to other types of mining or other areas of Appalachia.

Methods. Mortality rates, poverty rates, Appalachian designation and mining activity were examined for counties in Kentucky, Tennessee, Virginia and West Virginia (N=403). Linear least squares models tested for annual group differences from 2000-2007 in total and child poverty, and total mortality, based on mining type and Appalachian location. Nested linear models accounting for state-level …

T-Scores In African American Women, Catherine Meyer, Brooke L. Griffin, Kathy Komperda, Jill Borchert

Journal of Health Disparities Research and Practice

Many older bone densitometer (DXA) machines are programmed to calculate T-scores for African- American patients using peak African-American bone mass as reference standard.

This presents a problem because most data regarding fracture risk has been derived using Caucasian data (Binkley 2002). If the T-score for an African-American woman is calculated using a race-adjusted reference, the same absolute bone density will yield a lower T-score for an African- American than for a Caucasian woman. For this reason, the International Society for Clinical Densitometry has recommended that T-scores for all women, regardless of ethnicity, be calculated from Caucasian reference standards (ISCD 2007).

Results Of Universal Prenatal Screening For Hepatitis C Infection In A Remote American Indian Primary Care Population, Christine Dubray, John T. Redd, Cecile M. Town, Kathy K. Byrd, Supriya Janakiraman, Anindya K. De, James E. Cheek

Journal of Health Disparities Research and Practice

BACKGROUND: Although chronic liver disease remains a major area of health disparity for American Indian (AI) people, the epidemiology of hepatitis C virus (HCV) infection among AI people is poorly documented. Because of suspected high local prevalence, two remote AI clinics in the Northern Plains implemented universal prenatal HCV screening in 2005. When this screening program reported an unexpectedly high prenatal anti-HCV (anti-HCV antibody) positivity rate, we conducted a case-control study to determine risks for infection and opportunities for community intervention.

MAIN FINDINGS: The clinics screened a total of 205 pregnant women (median age, 22 years). Of these 205 women, …

Responding To American Indian Communities: Southwest American Indian Collaborative Network (Saicn) Cancer Educational Activities, Naomi A. Lane, Kathleen Evans, Agnes Attakai, Catherine Witte, Maylynn Riding In-Warne, Kathryn Coe

Journal of Health Disparities Research and Practice

Developing educational materials and providing trainings in American Indian communities is a highly rewarding activity. However, to do so successfully a number of complex issues must be faced and cultural-tailored strategies to promote awareness must be developed based on the unique traditions of each tribe. In this paper we describe the educational activities conducted over a four year period by the Southwest American Indian Collaborative Network, a project funded by the National Cancer Institute’s Center to Reduce Cancer Health Disparities. Activities fell into two broad areas: dissemination of cancer information through trainings and workshops and development of culturally-tailored educational materials.

Value Of Community Partnership For Understanding Stress And Coping In Rural Yup’Ik Communities: The Canhr Study, Inna D. Rivkin, Ellen Lopez, Tonie M. Quaintance, Joseph Trimble, Scarlett Hopkins, Candace Fleming, Eliza Orr, Gerald V. Mohatt

Journal of Health Disparities Research and Practice

Stress and trauma can compromise physical and mental health. Rural Alaska Native communities have voiced concern about stressful and traumatic events and their effects on health. The goal of the Yup’ik Experiences of Stress and Coping Project is to develop an in-depth understanding of experiences of stress and ways of coping in Yup’ik communities. The long-range goal is to use project findings to develop and implement a community-informed and culturally grounded intervention to reduce stress and promote physical and mental health in rural Alaska Native communities. This paper introduces a long-standing partnership between the Yukon-Kuskokwim Regional Health Corporation, rural communities …

Advances In Ultrafast Time Resolved Fluorescence Physics For Cancer Detection In Optical Biopsy, R. R. Alfano

Publications and Research

We discuss the use of time resolved fluorescence spectroscopy to extract fundamental kinetic information on molecular species in tissues. The temporal profiles reveal the lifetime and amplitudes associated with key active molecules distinguishing the local spectral environment of tissues. The femtosecond laser pulses at 310 nm excite the tissue. The emission profile at 340 nm from tryptophan is non-exponential due to the micro-environment. The slow and fast amplitudes and lifetimes of emission profiles reveal that cancer and normal states can be distinguished. Time resolved optical methods offer a new cancer diagnostic modality for the medical community.

Outcome Of Revision Anterior Cruciate Ligament Reconstruction: A Systematic Review, Rick W. Wright, Corey S. Gill, Ling Chen, Robert H. Brophy, Matthew J. Matava, Matthew V. Smith, Nathan A. Mall

Open Access Publications

No abstract provided.

2012 March 20 - Medical Student Education Committee Minutes Called Meeting, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

The Graded Redefined Assessment Of Strength Sensibility And Prehension: Reliability And Validity., Sukhvinder Kalsi-Ryan, Dorcas Beaton, Armin Curt, Susan Duff, Milos R Popovic, Claudia Rudhe, Michael G Fehlings, Mary C Verrier

Department of Physical Therapy Faculty Papers

Abstract With the advent of new interventions targeted at both acute and chronic spinal cord injury (SCI), it is critical that techniques and protocols are developed that reliably evaluate changes in upper limb impairment/function. The Graded Redefined Assessment of Strength Sensibility and Prehension (GRASSP) protocol, which includes five subtests, is a quantitative clinical upper limb impairment measure designed for use in acute and chronic cervical SCI. The objectives of this study were to: (1) establish the inter-rater and test-retest reliability, and (2) establish the construct and concurrent validity with the International Standards of Neurological Classification of Spinal Cord Injury (ISNCSCI), …