Medicine and Health Sciences Commons^™

Short Term Results Of Ligament Reconstruction And Tendon Interposition Resection Arthroplasty For Basal Joint Arthritis, Kashif Abbas, Pervaiz Hashmi, Hasnain Raza

Section of Orthopaedic Surgery

Carpometacarpal (CMC) joint of the thumb is the second most common site afflicted by osteoarthritis. Non surgical measures forms the first line of treatment with aim of preventing progression of disease, however, surgery becomes an option when symptoms are refractory to nonsurgical methods. Different procedures have been described in literature. Ligament reconstruction with tendon interposition (LRTI) is the most commonly performed procedure in North America for this problem. The Aim of study was to evaluate early results of ligament reconstruction and tendon interposition for CMC joint arthritis. This is a case series of ten patients operated in a tertiary care …

Expression Of Stem Cell Marker Aldh1 In Cervical Intraepithelial Neoplasia, Ping Gong, Juan Palazzo, Md

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Conclusions:

Cervical dysplasia show positive staining for ALDH1 compared to normal cervical mucosa.

ALDH1 positive cells distribution parallels the dysplastic cells in cervical dysplasia.

CSC, as detected by ALDH1 expression, may play a role in the progression of cervical intraepithelial neoplasia and carcinogenesis.

Aberrant Expression Of Cd56 On Granulocytes And Monocytes In Myeloproliferative Neoplasm And Myelodysplastic Syndrome, Ping Gong, Md, Fernanco Metrebian, Md, Alina Dulau-Florea, Md, Zi-Xuan Wang, Phd, Renu Bajaj, Phd, Stephen C Peiper, Jerald Z. Gong, Md

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Conclusions:

Aberrant CD56 expression on granulocytes is seen in all aubtypes MPN and high grade MDS. CD56 expression in MPN correlated with bone marrow morphology, BCR/ABL transcript, and bone marrow engraftment study following treatment. Identification of abnormal CD56+ granulocytes and monocytes is helpful in both the initial diagnosis and long-term follow up of patients with MPN and MDS.

Loss Of Retinoblastoma (Rb) Tumor Suppressor Expression In Breast Cancer Correlates With Better Response To Neoadjuvant Chemotherapy, Jeanne Mcfalls, Md, Jessica Kline, Ba, Gordon Schwartz, Md, Mba, Facs, Angieszka Witkiewicz, Md

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Conclusions:

Loss of RB tumor suppressor staining in pre-treatment breast cancer biopsies can be used prior to initiation of neoadjuvant chemotherapy to predict good tumor response. This association between RB loss and good neoadjuvant response holds regardless of ER status and across various chemotherapy regimens. Assessment of RB status in the pre-treatment biopsy could be useful clinical tool to define patients who are most likely to benefit from neoadjuvant chemotherapy.

P53 Expression In Oropharyngeal Squamous Cell Carcinoma In Increased In Hpv Positive Smokers, Madalina Tuluc, Voichita Bar-Ad, Zi-Xuan Wang, Joseph Curry

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background and Objectives

High risk HPV is associated with oropharyngeal SCC (OSCC) and is responsible for the increasing incidence of this cancer type among younger patients.

Patients with HPV positive oropharyngeal SCC have a better prognosis when compared with HPV negative, tobacco induced SCC.

HPV E6 inactivates p53 leading to low expression of p53; tobacco induced oropharyngeal SCC is characterized by p53 overexpression, resistance to treatment and poor prognosis. However, in many cases of HPV OSCC, there is a history of current or remote smoking, making this disease a multifactorial process. We expect that smoking will influence the level of …

P16/Rb Correlations In Oropharyngeal Squamous Cell Carcinoma (Oscc), Madalina Tuluc, Voichita Bar-Ad, David Cognetti

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The objective of this study is to explore the patterns of Rb expression in p16 positive and negative OSCC, in relation to patient's smoking history.

The Metastasis Suppressor Kiss1 Lacks Antimetastatic Activity In The C8161.9 Xenograft Model Of Melanoma., Jean-Marc Navenot, Barry Evans, Shinya Oishi, Shohei Setsuda, Nobutaka Fujii, Stephen C Peiper

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The objective of this study was to use the established xenograft model of human melanoma (C8161.9) to test a pharmacological approach to the effect of the metastasis suppressor KISS1. A KISS1 analog was used to inhibit the metastatic development of C8161.9 cells in nude mice. Further experiments were performed to test the validity of the C8161.9 model and test the connection between KISS1 expression and loss of metastatic potential. New clones of C8161.9 cells were obtained, with or without KISS1 expression, and were tested for metastasis formation. The absence of benefit in survival with the KISS1 analog compared with PBS …

Urine Drug Testing In A Sickle Cell Population Treated With Chronic Opioids, David J. Axelrod, Md, Jd, Elisabeth Congdon-Martin, Lsw, Elizabeth Pulte, Md

Division of Internal Medicine Faculty Papers & Presentations

Purpose: A review of UDT results of patients with sickle cell disease over a three-year period. UDT was conducted on patients who were prescribed long-term opioids for daily use. UDTs were tested at least once a year, and in selected patients more frequently.

The Future Of Nursing: How Important Is Discipline-Specific Knowledge? A Conversation With Jacqueline Fawcett, Janie B. Butts, Karen L. Rich, Jacqueline Fawcett

Faculty Publications

Nurses have long attempted to secure a unique identity for the profession. Many scholars are now promoting an interdisciplinary framework for nursing practice. Fawcett is convinced that interdisciplinary practice poses a danger for nursing to lose its identity and that interdisciplinary practice cannot be successful if members of each discipline do not understand the conceptual models, practice, and research of their own discipline. Dr. Janie Butts and Dr. Karen Rich interviewed Dr. Jacqueline Fawcett about her views related to discipline-specific knowledge and nursing's future. The authors conclude that Fawcett's scientific foundation gives nursing the solidarity and power necessary to determine …

California School Nurses' Knowledge, Attitude, And Intention To Participate In Sexuality Education, Maria G. Matza Phd, Msn, Rnc

Dissertations

A critical need exists to provide adolescents with sexual health education as demonstrated by our nation's position in having the highest adolescent pregnancy rates among all the developed nations. The critical need is further pronounced by California's changing demographic profile of young Latinos who are projected to be the majority in 2042 and continue to demonstrate higher pregnancy and birth rates than other racial and ethnic groups. Currently, there is limited evidence to confirm if California's students are receiving sexual and reproductive health as required by law, nor is there evidence to link school nurses as teachers or consultants in …

We Rock – You Roll: Surgical Staging Unit Propels On-Time First Case Start Initiative, Marlene Mayza Bsn, Rn, Janice Magliane Adn, Rn

Patient Care Services / Nursing

No abstract provided.

Post-Operative Instructions & Information, Maura Diehl Rn, Cpan

Patient Care Services / Nursing

No abstract provided.

Insights To Patient Care Continuum: A Collaborative Approach From To Rehabilitative Care Settings, Holly D. Tavianini Rn, Bsn, Mshsa, Crn, Amber Moyer Rn, Bsn, Cnrn, Carol Domzalski Rn, Crrn, Jolene Klotz Rn,Msn,Crrn

Patient Care Services / Nursing

No abstract provided.

Just Do It—A Just Culture To Move From Blame To True Remediation, Jaclyn Bergstol Rn

Patient Care Services / Nursing

No abstract provided.

Oncology Nurses' Cultural Competence, Knowledge, And Attitudes Toward Cancer Pain, Ayman Alnems Phd, Msn, Rn

Dissertations

Effective pain management requires appropriate knowledge, attitudes, and assessment skills. The purposes of this study were to obtain information about the knowledge and attitudes of oncology nurses related to cancer pain and its management, to evaluate oncology nurses' cultural competence, and to investigate relationships between oncology nurses' cultural competence and their pain management knowledge and attitudes. Ferrell and McCaffery's (2008) Nurses' Knowledge and Attitude Survey Regarding Pain (NKASRP), the Cultural Competence Assessment Survey (CCA) (Doorenbos, Schim, Benkert, & Borse, 2005; Schim, Doorenbos, Miller, & Benkert, 2003), and a demographic questionnaire were used to measure oncology registered nurses' cultural competence and …

Factors And Health Promoting Behaviors That Influence Maternal And Infant Outcomes In Older Pregnant Thai Women, Supawadee Thaewpia Phd, Msn, Rn

Dissertations

This dissertation summarizes research conducted in partial fulfillment of the program requirements for the Doctor of Philosophy in Nursing degree from the Hahn school of Nursing and Health Sciences, University of San Diego. The results of the dissertation research are organized as three discrete papers. Article one is entitled; "Reliability and Validity of Thai Translations of Instruments Measuring Psychosocial Factors and Health Promoting Behaviors among Older Pregnant Thai Women." This article describes the dissertation research study in which the selected instruments were piloted at an antenatal clinic in Thailand. The article determines the instruments' ability to examine perceived benefits, perceived …

A Pilot Study Of The Evidence Based Practice Training Program For Filipino Physiotherapists: Emerging Evidence On Outcomes And Acceptability, Janine Margarita R. Dizon, Karen Grimmer-Somers, Saravana Kumar

Internet Journal of Allied Health Sciences and Practice

Background: The use of evidence to guide clinical practice has been challenging for health professionals across the globe. Issues of implementing the evidence become even more challenging among health professionals in developing countries because of cultural and contextual issues which compound the existing implementation barriers reported in the literature. An evidence based practice (EBP) training was developed for physiotherapists in a developing country (the Philippines) based on the literature and preliminary exploratory studies. The training program aimed to address issues of barriers to EBP and the nature of practice in a developing country. This study reports the process and findings …

Corticomotor Excitability During A Noxious Stimulus And Following Exercise In Women With Fibromyalgia, Marie K. Hoeger Bement, Andy Weyer, Tejin Yoon, Sandra K. Hunter

Physical Therapy Faculty Research and Publications

No abstract provided.

Synergistic Effect Of Subnanosecond Pulsed Electric Fields And Temperature On The Viability Of Biological Cells, James Thomas Camp

Electrical & Computer Engineering Theses & Dissertations

Pulsed electric fields have been used to induce a biological response in cells, and at sufficient energy, can cause cell death. By reducing the pulse duration from presently used nanosecond to subnanosecond ranges, the electric field can be delivered to biological tissue non-invasively by the use of an antenna instead of electrodes, such as needles. Studies have previously been completed in which the aim was to determine the energy density (electric field strength, number of pulses) required to induce cell death with 800 ps pulses. Based on this data, it was concluded that for pulse durations of 200 ps, with …

Recession Proof Pills: An Examination Of The Relationship Between Recession Economics And Pharmaceutical Expenditures, Kevin Gray

Annual Undergraduate Conference on Health and Society

The first decade of the 21st century proved to be a time of turbulence and volatility in the worldwide economy. Oddly enough, even as Americans’ disposable income decreased, spending on health care steadily increased. Americans spent $249.9 billion on prescription drugs in 2009, contrasted against $120.9 billion in 2000—a 105% increase.1 We may question the overall ramifications of such increases in pharmaceutical sales and the correlation to other economic factors. That is, how was the pharmaceutical sector able to boast gains when the housing market collapsed? One answer is that people place a priority on their health, even with limited …

Sick With Fear: Popular Challenges To Scientific Authority In The Vaccine Controversies Of The 21st Century, Ellen Watkins

Annual Undergraduate Conference on Health and Society

In the 20th century, vaccines were heralded as one of the greatest medical inventions in history. In the late 1990’s, however, the myth of vaccine-caused autism caught fire. Despite mountains of evidence disproving the link, panicking Americans eschewed vaccines and turned against their physicians. Why did Americans turn their backs on doctors, scientists, and the health industry? This paper follows the vaccine controversy of the last thirty years, looking in particular at the relationship between science and the media. This paper analyzes the contrast between discussion of the hypothesized link in scientific circles and in popular news sources, seeking to …

Sorry Buddy, But Your Name Isn't On The List: Fear And The Ethics Of Organ Donation In Film, Ted Callis

Annual Undergraduate Conference on Health and Society

The fear of death and illness is a powerful motivator. When taking into account the ethical reasoning that drives organ transplantation and procurement practices, it is persuasive enough to sway minds and corrupt pure reason. And so this paper will uncover how fear of illness and death shape answers to the ethical questions that arise in transplant debates and how these debates are in turn raised in the ethical dilemmas portrayed by popular American films. This paper will examine recent films such as The Island, and Never Let Me Go to illustrate how the ethical dilemmas associated with organ …

Facing An Epidemic: An Analysis Of Hiv/Aids, Antiretroviral Drug, And International Response To The Aids Pandemic, Michael Tate

Annual Undergraduate Conference on Health and Society

More than 33 million people are living with HIV/AIDS around the globe with 68% of all cases occurring in sub-Saharan Africa. The global prevalence rate is shocking considering that the disease was relatively unknown just 30 years ago. After reviewing medical, health policy, and health statistical journals, I will argue in this paper that international aid to nations struggling with AIDS needs to be redirected and refocused on supplying antiretroviral therapy to afflicted nations because ARV has been proven to be effective in managing the disease in countries that can afford the costs of treatment. International aid to countries that …

Medicines That Kill, Lina Ahmed Abushouk

Annual Undergraduate Conference on Health and Society

The prevalence of counterfeit drugs on the African continent has been increasing at an alarming rate. “Medicines that Kill” is a research paper that attempts to analyze the factors that make African countries particularly susceptible to this global threat. Nigeria, a country that has had some of the highest rates of counterfeit drugs in the world, is the main case study for this paper. Its efforts to combat the issue are compared and contrasted with those of Tanzania and Kenya in an attempt to understand what aspects of the issue are unique to Africa and the methods that have been …

Human Papillomavirus: How Social Ideologies Influence Medical Policy And Care, Fadi Hachem

Annual Undergraduate Conference on Health and Society

The purpose of this paper is to discuss the ways in which new advances in the production of a vaccine against human papillomavirus (HPV) have been received by both the general public and the medical community. Despite its high prevalence in the general population, as a sexually transmitted infection, there is a great deal of shame and stigma associated with contracting the virus (Waller, et. al. 2007). HPV is a disease of disparities in that ethnic and sexual minorities are disproportionately affected. Since the HPV vaccine is most effective at both a younger age, and before the first sexual experience, …

Sacrée Et Inviolable: The Hiv+ Mother In Ivoirian Health Policy, Amber Alaniz

Annual Undergraduate Conference on Health and Society

« La personne humaine est sacrée (2)… Le domicile est inviolable. Les atteintes ou restrictions ne peuvent y être apportées que par la loi. (4) La famille constitue la cellule de base de la société. L'État assure sa protection. (5)» Constitution of La Côte d’Ivoire, Articles 2,4,5[1]

The Ivoirian national constitution, authored and enacted in July of 2000, while expressing a devotion to democratic thought (Preamble) and to the sovereignty of the individual (Article 2), also acknowledges the primacy of the Ivoirian family and collective identity as the basis of society and advances a moral duty on the part …

The Pregnancy Project: Impact Of Ultrasound Use During Pregnancy Care, Paige Ricci

Annual Undergraduate Conference on Health and Society

Use of ultrasounds during pregnancy continues to increase and there is much debate as to what the best practice is regarding their use, for what types of patients, at what volume level. Current evidence suggests, the extended routine use of ultrasound technology should be for all women that present complications to screen for structural anomalies during pregnancy. However, others have suggested that excessive ultrasound use may be both unnecessary, costly and potentially harmful. Evidence further suggests that mothers find the use of technology to be security enhancing during pregnancy and through the process of care, and that ultrasound use is …

The Influence Of Neighborhood Characteristics On The Existence Of Asthma In Children, Elizabeth Adejuyigbe

Annual Undergraduate Conference on Health and Society

Asthma is one of the leading chronic diseases in children 17 years of age and under with nine million American children suffering from it. Previous studies to understand causal factors of disease including asthma tend to focus on the individual and sociocultural characteristics but there is little to no research using neighborhood characteristics, a factor that does influence health. Research shows that other community‐level environmental factors like collective efficacy, community structural factors, and neighborhood safety can affect a persons’ psychosocial well-being, and in turn increase morbidity. For this reason, researchers suggest that the need to understand asthma and its associated …

To Live Means To Suffer: Exploring The Identity Of Chronic Pain Conditions, Gabriela Harris

Annual Undergraduate Conference on Health and Society

This paper examines the necessary identity reconstruction for chronic pain patients through the use of illness narratives. The biographical interruption of a chronic illness, partnered with the patients’ inability to discuss embodiment and pain wholly (because language failures to capture the essence of pain and suffering) creates a devastating chasm between the world of the healthy and the world of the sick. Psychosomatic pain, and illnesses without diagnosis, are all the more divisive conditions, because these factors rob the patient further, disallowing them from constructing even an illness identity. Utilizing published patient interviews, sociological and anthropological texts, as well as …

Hiv/Aids: Ayurvedic Medicine's Impact On India's Social Stigma, Shawn Francis

Annual Undergraduate Conference on Health and Society

Ayurvedic medicine is an ancient form of treatment that has existed in India through scriptures and generations for thousands of years. It is practiced by “indigenous medical practitioners” or natural medical practitioners that assume the role of healers and use various forms of herbal remedies to treat individuals that have a form of illness. (Kakar DN. 1983) According to the C.D.L. College of Ayurveda, Ayurvedic medicine focuses on viewing the individual holistically through the body, mind, food, and environment to produce a medicinal recipe to meet the needs of the individual. In addition, the college has also mentioned that they …