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College of Public Health: News & Publications

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Predator-Based Fear Conditioning: A Novel Approach To The Study Of The Neurobiology Of Memory, Joshua D. Halonen

USF Tampa Graduate Theses and Dissertations

This series of experiments developed novel paradigms involving the integration of conventional and ethologically relevant forms of reinforcement in the study of fear conditioning in rats. Experiment 1 compared the effects of foot shock, immobilization and predator exposure, alone and in combination, on the expression of conditioned fear memory and extinction. The combination of all 3 reinforcers produced a significantly stronger fear memory and greater resistance to extinction, compared to when each reinforcer was administered alone. Furthermore, whereas conditioning with foot shock, alone, resulted in rapid extinction of the fear memory, the combination of immobilization and cat exposure, or all …

Enhancing The Immune Response Through Ikkbeta-Induced Activation Of Nf-Kappab, Emily Hopewell

USF Tampa Graduate Theses and Dissertations

Nuclear factor-κB (NF-κB) is one of the main regulators of inflammatory and immune responses. It is a family of transcription factors composed of five members: RelA, RelB, cRel, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Homo- and hetero-dimers of family members are inhibited by inhibitor of &klappaB (IκB) family members and activated by IκB kinase (IKK) family members. The IKK family is comprised of IKKα, IKKΒ, and IKKγ. The focus of my dissertation delves into the role of NF-κB activation by IKKΒ in both an immunotherapy setting and its role in T cell mediated anti-tumor immune responses.

A central focus of immunotherapy …

Medical School Watercooler Newsletter - April 8, 2012, Lindsey Lyle

Watercooler Newsletter

This is the April 8, 2012 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Health Services Foundation Announces Customer Service Recognition Program
• USA Libraries Book Drive Ends Friday
• April Med School Café: Evidence-Based Treatments for Autism Spectrum Disorders
• Annual Fund Gift Basket Winner Announced
• Next Week's DSS - Dr. Augustine M.K. Choi

Parallel Lives: Similarities Between The Lived Experiences Of Persons With Cancer And Hiv, Danielle Boyd '12

Honor Scholar Theses

Thave chosen to focus this analysis on the shared experiences of patients with the socially stigmatized and incurable illnesses of cancer and HIV. These people cannot have their patient experience ended by a nice little pill or vaccine. They must blindly put their hopes in painful treatment regimens that can offer only management of their condition. They often undergo the tremendously helpless experience of feeling one’s body decline. As their treatment or the illness itself progresses they must enlist the help of family and friends to help them with daily tasks. Obviously the shared experiences of these two patient populations …

Red Chairs And Green Monsters: The Evolution Of Fan Culture In Boston Baseball, Kristina Mclane '12

Honor Scholar Theses

No abstract provided.

Causes Of The Vietnamese Brain Drain Syndrome, Phuong Nguyen '12

Honor Scholar Theses

In 2010, Vietnam had more than 2 million emigrants residing in countries such as: the United States, Australia, Canada, Germany, France, the Republic of Korea, Japan, and the United Kingdom (World Bank). This number of emigrants accounted for 2.5% of the whole domestic population. Also according to this date, the emigration rate of tertiary-educated population was 27.1% in 2000. Due to relatively high number of emigrants, Vietnam has experienced rapid growth in receipts of remittances recently. Hernandes-Cross (2005) reports that the amount of remittances sent to Vietnam from other countries reached USD $1.2 billion in 1999. By 2003, this number …

Binding Efficacy Of Different Polyphenolic Phytochemicals With Β-Lactoglobulin And Human Serum Albumin: Implication For Therapeutics Against Neurodegenerative Diseases, Rene Duran^, Andres Ortiz^, Mahesh Narayan*, Vladik Kreinovich*

COURI Symposium Abstracts, Spring 2012

No abstract provided.

Safety, Ergonomics And Human Factors Engineering On Biomedical Devices Design, Alejandra Sandoval Vazquez^, Noe Vargas Hernandez*

COURI Symposium Abstracts, Spring 2012

No abstract provided.

Meditation: The Physiological And Psychological Benefits, Karishma Kollipara '12

Honor Scholar Theses

No abstract provided.

Biochemical Characterization Of The Interaction Of The Hiv Cellular Cofactor Ledgf/P75 With The Transcriptional Regulator Fact Complex, Andre F. Perez^, Laura F. Porras, Angelica Lopez, Chang-Soo Seong, Manuel Llano*

COURI Symposium Abstracts, Spring 2012

No abstract provided.

Cholesterol Levels And Cardiovascular Health Indicator Changes In A Holistic Health Treatment Program: An Archival Study, Carolyn Taylor

Capstone Research Projects

Approximately 16.3% of the adult population in the United States maintains elevated levels of total cholesterol, and the components of the cholesterol profile—HDL, LDL, and triglyceride levels, among others—are particular determinants of cardiovascular disease risk. High levels of LDL in particular are associated with coronary atherosclerosis and cardiovascular disease. Conversely, high levels of HDL remove cholesterol from the blood and aid in metabolism. The HDL/LDL ratio is considered a marker of carotid plaque and is specifically used as an indicator for cardiovascular disease risk. Traditional cholesterol control treatment utilizes statin therapy and antihypertensive medication; however, recent trends toward alternative methods …

Instituting An Oral Health Preventive Service Program, Including Fluoride Varnish, For Preschool Children Birth To Five Years In A Rural Health Clinic: A Clinical Scholarship Project, Carol Ann Berger

Dissertations

Abstract This project was designed to institute an oral health preventive program in a rural health clinic, in a dental provider shortage area, promoting oral health in preschool children birth to five years by: (a) instituting a program that supports the Missouri preventive service program in oral health, (b) promoting oral screenings and fluoride varnish twice yearly, (c) assessing the risk of caries, (d) referring to appropriate dental services and (e) educating parents or guardian about the importance of oral health and how to maintain oral health at home with children birth to five years. This project sought to answer …

Development Of An Advanced Practice Registered Nurse Primary Care Telephone Clinic, Linda G. Kaiser

Dissertations

Abstract Development of an Advanced Practice Registered Nurse Primary Care Telephone Clinic This pilot project developed and implemented a telephone clinic based on established Veterans Affairs telephone policy and procedures and determined patient acceptability of this new visit type as an alternative to face to face visits. The review of the literature produced research that indicates telephone clinics are a viable visit option for patients. Telephone visits provide access to the primary care provider while being convenient and economical for patients. Research studies demonstrate that patients are satisfied with this visit option. The pilot project was successfully implemented in a …

Closing The Loop: Integrating Snapps Into An Outpatient Morning Report To Foster Self-Directed Learning And Encourage Use Of Evidence Based Medicine, Julia Magana, Jimmy Beck

E-Learning Modules

This resources describes a novel approach to outpatient morning report. This format encourages self-directed learning as well as teaches residents to use the clinical literature to ensure they were providing optimal patient care. Each resident daily chooses a clinical question from that day's patient care, investigates and brings the answer back to the group during morning report. This resource includes a description of the integration and implementation of this format as well as the handout used by the residents.

Since the implementation of our new morning report format, our residents have consistently read about their patients on a nightly basis. …

Genetic Association Studies Of Copy-Number Variation: Should Assignment Of Copy Number States Precede Testing?, Patrick Breheny, Prabhakar Chalise, Anthony Batzler, Liewei Wang, Brooke L. Fridley

Biostatistics Faculty Publications

Recently, structural variation in the genome has been implicated in many complex diseases. Using genomewide single nucleotide polymorphism (SNP) arrays, researchers are able to investigate the impact not only of SNP variation, but also of copy-number variants (CNVs) on the phenotype. The most common analytic approach involves estimating, at the level of the individual genome, the underlying number of copies present at each location. Once this is completed, tests are performed to determine the association between copy number state and phenotype. An alternative approach is to carry out association testing first, between phenotype and raw intensities from the SNP array …

Regulation Of Natural Killer Cells: Ship-1, 2b4, And Immunomodulation By Lenalidomide, Nicole Renee Fortenbery

USF Tampa Graduate Theses and Dissertations

Natural Killer cells (NK) are critical components of the innate immune system. Often referred to by their morphology, these large granular lymphocytes (LGLs) are bone marrow-derived lymphocytes and can be found throughout the body. NK cells reside in the liver, lymph nodes, spleen, thymus, and mucosal-associated lymphoid tissues (MALT). Importantly, NK cells also circulate throughout the blood where they function as surveyors of the body and are armed to eliminate malignant, infected, damaged, or foreign cells.

NK cells function by a dual receptor system. That is, NK receptors are broadly categorized as inhibitory or activating. It is a fine balance, …

Adjunct Primer For The Use Of National Comprehensive Cancer Network Guidelines For The Surgical Management Of Cutaneous Malignant Melanoma Patients., Edibaldo Silva

Journal Articles: Oncology and Hematology

Recently, a Surveillance Epidemiology and End Results (SEER) survey of melanoma patterns of care by the Mayo Clinic, Scottsdale showed remarkable deviations from best practice patterns throughout the country. The study, which analyzed the SEER records of 35,126 stage I to III cutaneous malignant melanoma patients treated from 2004 to 2006, showed that adherence to National Comprehensive Cancer Network (NCCN) therapeutic resection margins occurred in less than 36% of patients. Similarly, considerable variation in the quality of melanoma care in the United States when assessed using 26 quality indicators drawn by a panel of melanoma experts was independently reported. These …

Proceedings - Wright State University Boonshoft School Of Medicine Fourth Annual Medical Student Research Symposium: Celebrating Medical Student Scholarship, Office Of Research Affairs, Boonshoft School Of Medicine

Medical Student Research Symposium Proceedings

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Fourth Annual Boonshoft School of Medicine Medical Student Research Symposium held on April 5, 2012.

Genome-Wide Microrna Profiling Of Mantle Cell Lymphoma Reveal A Distinct Subgroup With Poor Prognosis, Javeed Iqbal, Yulei Shen, Yanyan Liu, Kai Fu, Elaine Jaffe, Cuiling Liu, Zhongfeng Liu, Cynthia Lachel, Karen Deffenbacher, Timothy Greiner, Julie Vose, Sharathkumar Bhagavathi, Louis Staudt, Lisa Rimsza, Andreas Rosenwald, German Ott, Jan Delabie, Elias Campo, Rita Braziel, James Cook, Raymond Tubbs, Randy Gascoyne, James Armitage, Dennis Weisenburger, Timothy Mckeithan, Wing Chan

United States Public Health Resources

MicroRNA (miRNA) deregulation has been implicated in the pathogenesis of mantle cell lymphoma (MCL). Using a high-throughput quantitative real-time PCR platform, we performed miRNA profiling on cyclin D1- positive MCL (n=30) and cyclin D1-negative MCL (n=7) and compared them with small lymphocytic leukemia/lymphoma (SLL, n=12), aggressive B-cell lymphomas (n=138), normal B-cell subsets and stromal cells. We identified a 19-miRNA classifier which included six upregulated miRNAs (miR-135a, miR-708, miR-150, miR-363, miR-184, miR-342-5p) and 13 downregulated miRNAs, that was able to distinguish MCL from other aggressive lymphomas with >90% probability. Some of these upregulated miRNAs are highly expressed in naïve B-cells. MicroRNA …

Data Sharing In Neuroimaging Research, Jean-Baptiste Poline, Janis L. Breeze, Satrajit Ghosh, Krzysztof Gorgolewski, Yaroslav O. Halchenko

Dartmouth Scholarship

Significant resources around the world have been invested in neuroimaging studies of brain function and disease. Easier access to this large body of work should have profound impact on research in cognitive neuroscience and psychiatry, leading to advances in the diagnosis and treatment of psychiatric and neurological disease. A trend toward increased sharing of neuroimaging data has emerged in recent years. Nevertheless, a number of barriers continue to impede momentum. Many researchers and institutions remain uncertain about how to share data or lack the tools and expertise to participate in data sharing. The use of electronic data capture (EDC) methods …

Evaluating Effectiveness Of A Public Mental Health Re-Entry Program: Strategic Statewide Partnerships, Stephanie Hartwell

Office of Community Partnerships Posters

This study is the first ever initiative to merge administrative data base in Massachusetts to evaluate an important public mental health program. It examines post-incarceration outcome of adults with serious mental illness (SMI) enrolled in the Massachusetts Department of Mental Health (DMH) Forensic Transition Team (FTT) program. The Program began in 1998 with the goal of transitioning offenders with SMI released from state and local correctional facilities utilizing a core set of transition activities. In this study we evaluate the program's effectiveness using merged administrative data from various state agencies for the years 2007 - 2011, comparing FTT clients to …

Honduras: Local, Regional And Global Partnerships To Improve Health In Olancho, Lisa Kennedy Sheldon, Hasan Bailey, Carlo Najera, Mary Roy

Office of Community Partnerships Posters

The Honduran Mission Team-New Hampshire (HMT-NH) in partnership with the Olancho Aid Foundation (OAF), works in the Olancho department to improve the health and education of the Honduran people. The HMT-NH 2012 Healthcare Team included UMass Boston faculty and a nursing student working with American and Honduran doctors and nurses to provide culturally-appropriate healthcare and collect data about the needs of the Honduran people in Olancho.

Institute For Community Inclusion (Ici) Leadership Education In Neurodevelopmental Disabilities (Lend) Partners With Community-Based Organizations (Cbos), David Helm, Institute For Community Inclusion, University Of Massachusetts Boston

Office of Community Partnerships Posters

This Interdisciplinary Leadership Education in Neurodevelopmental and Related Disabilities (LEND) and Maternal and Child Health Bureau (MCHB) funded-program aims at providing long-term, graduate level interdisciplinary training to health professionals and family members. The purpose of this project is to develop leadership potential to improve the health status of infants, children, and adolescents with or at risk for neurodevelopmental and related disabilities and to enhance the systems of care for these children and their families.

Working Together: Recruiting African American Female Caregivers And Pre-Adolescent Girls For Longitudinal Study, Teri Aronowitz, Wendy Pavlovich

Office of Community Partnerships Posters

The aim of this project is to implement an enhanced sexual communication intervention with mother-pre adolescent girls. It also aims to maintain the short term enhanced sexual communication intervention and evaluate the long term efficacy (9 months) of an enhanced sexual communication intervention with mothers and pre-adolescent girls. Finally the project aims to determine whether the constructs of the Information-Motivation-Behavioral skills (IBM) Model can account for variability in enhancing sexual communication intervention of mother and pre-adolescent girls.

Community Health Nursing Service Learning, Joyce K. Edmonds, Diane Coste

Office of Community Partnerships Posters

Through the Service Learning Course, College of Nursing and Health Sciences, RN-BS Online Program, Senior Level Course, Community Health for RN’s and NU 461, 6 credits Student Body Registered Nurses (70-105 each semester) throughout the state seeking to obtain a Bachelor in Science of Nursing. The Institute of Medicine, Future of Nursing Report recommends increasing the proportion of nurses with a baccalaureate degree to 80% by 2020. Instructional Aim Students obtain a better understanding of public health and nursing theory and practice as they further develop their professional and civic identities through meaningful service to their communities. Service Learning Requirement …

Gokids Boston Youth Fitness, Training, And Research Center, Meghan Feeley, Sarah Camhi, Dana Commesso, Gokids Boston, University Of Massachusetts Boston

Office of Community Partnerships Posters

GoKids Boston embodies innovation and leadership in youth health through life-changing programs, groundbreaking research, exceptional training opportunities, and dedication to the community with a focus on eliminating health disparities.

Increasing Physical Activity In Inner City Youth Using Novel Interactive Gaming, Sd De Ferranti, Sk Steltz, Scott Crouter, A Kim, Sk Osganian, Jessica Whiteley, H Feldman, Laura L. Hayman, Gokids Boston, University Of Massachusetts Boston

Office of Community Partnerships Posters

The aim of this project was to assess the feasibility of participation in an afterschool physical activity program incorporating novel exercise technologies on changing physical activity level and physical fitness, compared to a nutrition education intervention alone. A second objective was to assess whether this type of intervention could modify cardiovascular risk factors and anthropometrics.

Give Us Your Poor: A National Public Education Campaign Addressing Homelessness, Barbara L. Graceffa, Center For Social Policy, University Of Massachusetts Boston

Office of Community Partnerships Posters

The objective of this campaign to create awareness that the Government alone cannot solve homelessness. The campaign also creates awareness that corporations need to be involved to help bring to scale solutions as well as promote innovation. The aim of the project is to create an awareness that collaboration between government, non-profits, academia, corporations, faith communities, and individuals is key to solving the issue.

Inclusive National And Community Service: Bringing Together Service And Disability Communities, Paula Sotnik, Jewel Bazilio-Bellegarde, George Jesien, Felicia L. Wilczenski, Gayann Brandenburg, Debra Hart, Sheila Fesko, Stephan Hamlin-Smith, Alice Krueger

Office of Community Partnerships Posters

National service and volunteer programs, seeking to reflect the diversity of their communities, are increasing the participation of individuals with disabilities as members, volunteers, and leaders and working to ensure each individual has a meaningful service experience. In order to support their inclusive efforts, the National Service Inclusion Project (NSIP) brings together the national service and disability communities at a local, state, and national level. Through partnership building, strategic planning, and resource sharing, there have been measureable increases in numbers of service participants with disabilities and the quality of their experience.