Medicine and Health Sciences Commons^™

Diagnostic Accuracy Of Clinical Examination In Cervical Spine Injuries In Awake And Alert Blunt Trauma Patients, Manzar Hussain, Gohar Javed

Section of Neurosurgery

Study design: Observational, case series.
Purpose: To determine the sensitivity and specificity of clinical judgment as compared to the use of X-ray images in detecting cervical spine injuries in trauma patients presenting in the emergency department of Aga Khan University Hospital, Karachi.
Overview of literature: Cross-table cervical spine views are important in patients with signs and symptoms relating to cervical spine, but asymptomatic patients constitute a different subgroup. Accuracy of clinical examination in these patients has not been subjected to scrutiny.
Methods: All patients with blunt trauma who presented to the emergency department and underwent cross-table X-rays as part of …

Enhanced Neutralization Potency Of Botulinum Neurotoxin Antibodies Using A Red Blood Cell-Targeting Fusion Protein., Sharad P Adekar, Andrew T Segan, Cindy Chen, Rodney Bermudez, M D Elias, Bernard H Selling, B P Kapadnis, Lance L Simpson, Paul M Simon, Scott K Dessain

Division of Infectious Diseases and Environmental Medicine Faculty Papers

Botulinum neurotoxin (BoNT) potently inhibits cholinergic signaling at the neuromuscular junction. The ideal countermeasures for BoNT exposure are monoclonal antibodies or BoNT antisera, which form BoNT-containing immune complexes that are rapidly cleared from the general circulation. Clearance of opsonized toxins may involve complement receptor-mediated immunoadherence to red blood cells (RBC) in primates or to platelets in rodents. Methods of enhancing immunoadherence of BoNT-specific antibodies may increase their potency in vivo. We designed a novel fusion protein (FP) to link biotinylated molecules to glycophorin A (GPA) on the RBC surface. The FP consists of an scFv specific for murine GPA fused …

Today - March 2, 2011, Loma Linda University

TODAY

Inside this issue:

-- NSF-funded AIM lab opens LLU School of Medicine
-- Zhejiang Provincial People's Government presents friendship award to LLU Global Health Institute associate director
-- Student and future dietitian headed to John Hopkins for clinical practicum
-- Student's love for missions further quickened during Honduras trip
-- School of Pharmacy student wins essay contest for Amazon mission trip
-- Payscale.com names LLU among tops for starting salaries in the nation
-- LLU School of Religion hosts renowned biblical scholar from Scotland
-- Loma Linda University Medical Simulation Center features art exhibit
-- Pharmacy celebrates four years success …

Are Dropped Osteoarticular Bone Fragments Safely Reimplantable In Vivo?, Benjamin Bruce, Shahin Sheibani-Rad, Deborah Appleyard, Ryan P. Calfee, Steven E. Reinert, Kimberle C. Chapin, Christopher W. Digiovanni

Open Access Publications

No abstract provided.

Identification And Characterization Of Low Ph-Triggered Conformational Changes In The Herpes Simplex Virus Glycoprotein B, Stephen Dollery

Theses and Dissertations

Herpesviruses can enter host cells by pH-dependent endocytic pathways in a cell-specific manner. The role of pH in herpesvirus endocytosis is unclear. Herpes simplex virus (HSV) is a paradigm for virus membrane fusion via a complex of glycoproteins. HSV glycoproteins B, D and the heterodimer H-L are necessary and sufficient for membrane fusion. This work analyzes the structure and function of HSV glycoproteins B, D, and H-L at neutral pH, and at the physiological low-pH encountered during endocytic entry. It is demonstrated that mildly acidic low pH triggers specific conformational changes in HSV gB at a pH of 5.7 to …

Loss Of Neuronal Integrity During Progressive Hiv-1 Infection Of Humanized Mice., Prasanta Dash, Santhi Gorantla, Howard Gendelman, Jaclyn Knibbe, George P. Casale, Edward Makarov, Adrian A. Epstein, Harris A. Gelbard, Michael D. Boska, Larisa Y. Poluektova

Journal Articles: Radiology

Neuronal damage induced by ongoing human immunodeficiency virus type 1 (HIV-1) infection was investigated in humanized NOD/scid-IL-2Rγ(c)(null) mice transplanted at birth with human CD34-positive hematopoietic stem cells. Mice infected at 5 months of age and followed for up to 15 weeks maintained significant plasma viral loads and showed reduced numbers of CD4(+) T-cells. Prospective serial proton magnetic resonance spectroscopy tests showed selective reductions in cortical N-acetyl aspartate in infected animals. Diffusion tensor imaging revealed structural changes in cortical gray matter. Postmortem immunofluorescence brain tissue examinations for neuronal and glial markers, captured by multispectral imaging microscopy and quantified by morphometric and …

Substance Abuse In Georgia, The Burruss Institute Of Public Service And Research

Georgia Journal of Public Policy

In order to create a snapshot of substance use and abuse in Georgia, the Burruss Institute of Public Service and Research requested access to data from the National Survey on Drug Use and Health conducted on behalf of the Substance Abuse and Mental Health Services Administration (SAMHSA), a unit of the Department of Health and Human Services (HHS).  SAMHSA would not provide access to the raw data; instead, the Institute was given a series of tables with estimates of the average annual number of users of various substances among Georgians ages 12 and older between the years 2002 and 2008. …

Integrative Health Studies Newsletter, Ciis

Integrative Health Studies Newsletter

This is the Spring 2011 issue of the Integrative Health Studies Newsletter at CIIS.

Angiostatin Like Peptides In Milk: Potential Development For Dairy Products Capable Of Cancer Prevention, Erin Stefanutti

Master's Theses

For the past 40 years, antiangiogenic approaches have been of major interest in the development of methods to cure and prevent cancer. Angiogenesis, the development of blood vessels from pre-existing vascularization, is essential for cancer growth and spread of metastasis through the delivery of nutrients and oxygen essential to sustain the metabolic activity of these malignant cells. Blocking access to blood will cause cancerous cells to assume a dormant state creating inactive micro-tumors innocuous to the host. Angiostatin, the internal fragment of the fibrinolytic zymogen plasminogen, has shown great potential in reducing cancer size and number of metastatic colonies in …

In Translation V.1:No.3 (2011:Spring), Matthew J. Cook

UCHC Articles - Research

The Winter-Spring issue features an article on Dr. James Grady, the new director of the Biostatistics Center, and describes the biostatistics services being offered to CICATS investigators. You can also read about a TRIPP Center pilot and planning grant awarded to Dr. Rick Fortinsky and colleagues which helped to support a $400K grant from the National Institute for Nursing Research. Additional stories describe the activities of the Biomedical Informatics Division and the Correctional Health Services Research Core Interest Group (CIG)

Beliefs About Racism And Health Among African American Women With Diabetes: A Qualitative Study, Julie A. Wagner, Lisa M. Budris, Sophia Belay, Howard A. Tennen

UCHC Articles - Research

Exposure to racism has been linked to poor health outcomes. Little is known about the impact of racism on diabetes outcomes. This study explored African American (AA) women’s beliefs about how racism interacts with their diabetes self-management and control. Four focus groups were conducted with a convenience sample of 28 adult AA women with type 2 diabetes who were recruited from a larger quantitative study on racism and diabetes. The focus group discussions were transcribed verbatim and analyzed by the authors. Women reported that exposure to racism was a common phenomenon, and their beliefs did in fact link racism to …

Phagosomal Signaling By Borrelia Burgdorferi In Human Monocytes Involves Toll-Like Receptor (Tlr) 2 And Tlr8 Cooperativity And Tlr8-Mediated Induction Of Ifn-Β, Jorge L. Cervantes, Star M. Dunham-Ems, Carson J. La Vake, Mary M. Petzke, Justin D. Radolf, Juan C. Salazar

UCHC Articles - Research

Phagocytosed Borrelia burgdorferi (Bb) induces inflammatory signals that differ both quantitatively and qualitatively from those generated by spirochetal lipoproteins interacting with Toll-like receptor (TLR) 1/2 on the surface of human monocytes. Of particular significance, and in contrast to lipoproteins, internalized spirochetes induce transcription of IFN-β. Using inhibitory immunoregulatory DNA sequences (IRSs) specific to TLR7, TLR8, and TLR9, we show that the TLR8 inhibitor IRS957 significantly diminishes production of TNF-α, IL-6, and IL-10 and completely abrogates transcription of IFN-β in Bb-stimulated monocytes. We demonstrate that live Bb induces transcription of TLR2 and TLR8, whereas IRS957 interferes with their transcriptional regulation. Using …

Immunogenicity And Smoking Cessation Outcomes For A Novel Nicotine Immunotherapeutic, Cheryl A. Oncken

UCHC Articles - Research

NicVAX^®, a nicotine vaccine (3’AmNic-rEPA), has been clinically evaluated to determine if higher antibody concentrations are associated with higher smoking abstinence rates and if doses and frequency of administration are associated with increased antibody response. This randomized, double-blinded, placebo-controlled multicenter clinical trial (N=301 smokers) tested 200 and 400 µg doses administered 4 or 5 times over 6 months compared to placebo. 3’AmNic-rEPA recipients with the highest serum anti-nicotine antibody response (top 30% by AUC) were significantly more likely to attain 8 weeks continuous abstinence from weeks 19 through 26 than the placebo recipients (24.6% vs. 12.0%, p=0.024, OR=2.69, …

Medical Education Digest, Vol. 13 No. 2 (March/April 2011), Nova Southeastern University

Medical Education Digest

No abstract provided.

The Joseph Leiter Nlm/Mla Lecture At Mla '11, Anne Linton

Himmelfarb Library Faculty Publications

Description of the 2011 Joseph Leiter NLM/MLA Lecture.

Enhance And "Mobilize" The Library Catalog With Cloud Services, Jolinda Thompson

Himmelfarb Library Faculty Publications

Explores new products and services that make it possible to enhance and mobilize traditional library catalogs.

International Society Of Sports Nutrition Position Stand: Meal Frequency, Paul M. La Bounty, Bill I. Campbell, Jacob Wilson, Elfego Galvan, John Berardi, Susan M. Kleiner, Richard B. Kreider, Jeffrey R. Stout, Tim Ziegenfuss, Marie Spano, Abbie Smtih, Jose Antonio

Department of Health and Human Performance Faculty Articles

Position Statement: Admittedly, research to date examining the physiological effects of meal frequency in humans is somewhat limited. More specifically, data that has specifically examined the impact of meal frequency on body composition, training adaptations, and performance in physically active individuals and athletes is scant. Until more research is available in the physically active and athletic populations, definitive conclusions cannot be made. However, within the confines of the current scientific literature, we assert that:1. Increasing meal frequency does not appear to favorably change body composition in sedentary populations.2. If protein levels are adequate, increasing meal frequency during periods of hypoenergetic …

Active Movement Warm-Up Routines, Kim Fischer, Teri Walter

Health and Sport Sciences Faculty Scholarship

No abstract provided.

Second-Hand Smoke In A University Campus: Attitudes And Perceptions Of Faculty, Staff And Students, Cecilia M. Watkins, Sandeep Mishra, Herpreet Kaur Thind, Srinivasa B. Gokarakonda, Grace Lartey, Monia Chahal

Public Health Faculty Publications

Purpose: To examine the attitudes and perceptions of faculty, staff and students concerning tobacco policies at a university campus in a tobacco producing state. Methods: A questionnaire was administered to faculty, staff and students to assess knowledge, attitudes and beliefs related to smoking and exposure to second-hand smoke on campus. A 3-wave e-mailing was used to send the questionnaire. Results: A total of 2,914 individuals responded to the questionnaire. Majority (60%) of the participants believed a smoke free policy would be a positive move and could possibly improve the quality of life for the campus community, while not negatively affecting …

2011 March 1 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Topscholar® Creating Opportunities [2011 Brochure], Connie Foster, Jennifer Wilson

TopSCHOLAR® Presentations and Reports

No abstract provided.

The Effects Of Carbohydrate, Caffeine, And Protein On Endurance Performance, Tony Zapata

Kinesiology and Public Health

No abstract provided.

Alzheimer's Disease, Sophie Walsh

Kinesiology and Public Health

No abstract provided.

Mapping Cortical Morphology In Youth With Velocardiofacial (22q11.2 Deletion) Syndrome, Wendy R. Kates, Ravi Bansal, Wanda Fremont, Xuejun Hao, Anne Marie Higgins, Jun Liu, Robert J. Shprintzen, Bradley S. Peterson

Communication Disorders Faculty Publications

Objective: Velo-cardio-facial syndrome (VCFS; 22q11.2 deletion syndrome) represents one of the highest known risk factors for schizophrenia. Insofar as up to thirty percent of individuals with this genetic disorder develop schizophrenia, VCFS constitutes a unique, etiologically homogeneous model for understanding the pathogenesis of schizophrenia.

Method: Using a longitudinal, case-control design, we acquired anatomic magnetic resonance images to investigate both cross-sectional and longitudinal alterations in surface cortical morphology in a cohort of adolescents with VCFS and age-matched typical controls. All participants were scanned at two time points.

Results: Relative to controls, youth with VCFS exhibited alterations in inferior frontal, dorsal frontal, …

Chhs March 2011 E-Newsletter, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor, Wku College Of Health & Human Services

College of Health & Human Services Publications

No abstract provided.

Improving The Tracking And Removal Of Retrievable Inferior Vena Cava Filters., Anthony D Goei, Shellie C Josephs, Thomas B Kinney, Charles E Ray, David Sacks

Reading Hospital Interventional Radiology

Therapeutic and prophylactic inferior vena cava (IVC) filters should be placed based on currently accepted indications to prevent a fatal pulmonary embolism (PE). The protective effect of filters is offset by the potential for lower extremity deep venous thrombosis (DVT), caval thrombosis, and possible otherwise unnecessary life-long anticoagulation (AC). The duration of treatment for most DVTs or PEs is 3 to 6 months of AC/filter. Filters should be retrieved when duration of treatment for a DVT/PE has been met, the risk of a PE is no longer high, and/or there is no longer a contraindication to AC. An effective system …

Three Rs Approaches In The Production And Quality Control Of Fish Vaccines, Paul J. Midtlyng, Coenraad F.M. Hendriksen, Elisabeth Balks, Lukas Bruckner, Lawrence Elsken, Øystein Evensen, Kjetil Fyrand, Allison Guy, Marlies Halder, Penny Hawkins, Gunn Kisen, Anne Berit Romstad, Kira Salonius, Patrick Smith, Lynne U. Sneddon

Veterinary Science and Medicine Collection

The workshop on Three Rs Approaches in the Production and Quality Control of Fish Vaccines aimed a) to identify animal tests currently stipulated for the production and quality control of fish vaccines and to highlight animal welfare concerns associated with these tests; b) to identify viable options to replace, reduce, and refine animal use for fish vaccine testing; and c) to discuss the way forward and set out how the Three Rs may be implemented without jeopardizing the quality of the vaccines. The workshop participants -- experts from academia, regulatory authorities, a scientific animal welfare organization, and the fish vaccine …

The Use Of Non-Steroidal Anti-Inflammatory Drugs (Nsaids) In Treating Delayed Onset Muscle Soreness (Doms), Tiffany Windju

Kinesiology and Public Health

No abstract provided.

Perceived Benefits Of Yoga Participants Enrolled In Different Yoga Styles, Jennifer Lovas

Recreation, Parks, and Tourism Administration

Yoga affects the lifestyles of many individuals ranging from child and teen to senior. The Yoga Centre studios in San Luis Obispo and Arroyo Grande provide a variety of classes conducive to the yoga practice for all ages and levels. The purpose of this study was to examine the perceived benefits of participants enrolled in different styles of yoga at the Yoga Centre. The 163 participants completed the survey using self-administered and electronic questionnaires distributed in January of 2011. Stress relief was the highest perceived benefit. Most participants started yoga for health and fitness reasons and most were fearful of …

Correlation Of P16ink4a Expression And Hpv Copy Number With Cellular Ftir Spectroscopic Signatures Of Cervical Cancer Cells, Kamila Ostrowska, Amaya Garcia, Aidan Meade, Alison Malkin, Ifeoluwapo Okewumi, John O’Leary, Cara Martin, Hugh Byrne, Fiona Lyng

Articles

Cervical cancer, a potentially preventable disease, has its main aetiology in infection by high risk human papillomavirus (HR-HPV). Approaches to improving cervical cancer screening and diagnostic methodologies include molecular biological analysis, targeting of biomarker proteins, but also exploration and implementation of new techniques such as vibrational spectroscopy. This study correlates the biomarker protein p16^INK4A expression levels dependent on HPV copy number with the infrared absorption spectral signatures of the cervical cancer cell lines, HPV negative C33A, HPV-16 positive SiHa and CaSki and HPV-18 positive HeLa. Confocal fluorescence microscopy demonstrated that p16^INK4A is expressed in all investigated cell lines …