Medicine and Health Sciences Commons^™

Expression Of Lpp3 In Bergmann Glia Is Required For Proper Cerebellar Sphingosine-1-Phosphate Metabolism/Signaling And Development, Alejandro Lopez-Juarez, Sara Morales-Lázaro, Roberto Sánchez-Sánchez, Manjula Sunkara, Hilda Lomelí, Iván Velasco, Andrew J. Morris, Diana Escalante-Alcalde

Health & Biomedical Sciences Faculty Publications

Bioactive lipids serve as intracellular and extracellular mediators in cell signaling in normal and pathological conditions. Here we describe that an important regulator of some of these lipids, the lipid phosphate phosphatase-3 (LPP3), is abundantly expressed in specific plasma membrane domains of Bergmann glia (BG), a specialized type of astrocyte with key roles in cerebellum development and physiology. Mice selectively lacking expression of LPP3/Ppap2b in the nervous system are viable and fertile but exhibit defects in postnatal cerebellum development and modifications in the cytoarchitecture and arrangement of BG with a mild non-progressive motor coordination defect. Lipid and gene profiling studies …

Lsuhsc Facilities Daily Updates: April 2011, Lsuhsc Property And Facilities Management

LSUHSC Facilities Daily Updates: 2011

LSUHSC Facilities Daily Updates from April 2011.

April 4, 2011 is listed as a daily update but that page is blank in all seven instances captured by Archive.org

These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Lsuhsc Facilities Biweekly Update: April 2011, Lsuhsc Property And Facilities Management

LSUHSC Facilities Biweekly Updates: 2011

LSUHSC Facilities Biweekly Updates from April 8 and 22, 2011.

These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Implementing An Msn Nursing Program At A Distance Through An Urban-Rural Partnership, Ksenia Zukowsky, Phd, Aprn, Nnp-Bc, Beth Ann Swan, Phd, Crnp, Faan, Mary Powell, Phd, Crnp, Anthony J. Frisby, Phd, Lori Lauver, Phd, Rn, Margaret Mary West, Phd, Cne, Rn, Alexis Marsella, Ba

College of Nursing Faculty Papers & Presentations

Recruiting, retaining, and educating advanced practice nurses is essential to meet the growing need for advanced practice nurses in rural and urban communities. Through the support of Health Resources and Services Administration funding, the urban school of nursing expanded its MSN program and implemented the graduate curriculum on its rural campus by utilizing emerging online and distance education technologies. The purpose of this manuscript is to provide an overview of expanding an existing MSN program offered in an urban, traditional classroom setting to rural graduate nursing students via an online synchronous format. In addition, the article will describe the rural …

Gradenigo's Syndrome: Surgical Management In A Child, Hassan Nabeel Humayun, Shabbir Akhtar, Shakeel Ahmed

Section of General Surgery

Otits media is a common problem. Some of its complications that were seen frequently in the preantibiotic era are rare today. We report a case of an 8 year boy who presented with earache, retro-orbital pain and diplopia secondary to a sixth nerve palsy--Gradenigo's syndrome. In this syndrome infection from the middle ear spreads medially to the petrous apex of the temporal bone. Work-up includes CT scan of the temporal bones. Timely management with intravenous antibiotics (+ surgery) is needed to prevent intra-cranial complications.

Are Scores On The Ppt Useful In Determination Of Risk Of Future Falls In Individuals With Dementia?, Mary K. Farrell, Richard A. Rutt, Michelle M. Lusardi, Ann K. Williams

All PTHMS Faculty Publications

Individuals with dementia or Alzheimer’s disease (AD), exhibit both a progressive decline in cognitive function and accumulating difficulty with physical function.¹ As cognitive impairment begins, individuals will initially demonstrate difficulties with short-term memory and with instrumental activities of daily living. As the dementia progresses, individuals will increasingly demonstrate difficulties with long-term memory, communication, and basic activities of daily living.

A Case Study Of Health Interventions And The Caste System: Addressing The Social Determinants Of Health Through Development At Crhp Jamkhed, Laura Kroart

Independent Study Project (ISP) Collection

In the Southeast Asian country of India, the ancient but in some cases still rigidly intact caste system plays a role in determining health status and outcomes for much of its population of over 1.2 billion people.[1] The Comprehensive Rural Health Project, located in Jamkhed in the state of Maharashtra, India, approaches health interventions from a development standpoint, addressing biomedical needs, structural and environmental concerns, and the social and economic determinants of health that impact the lives of over a million villagers in the surrounding area.[2] This independent study project was designed to analyze how the Comprehensive Rural …

Evaluating Nurses Perceptions Of Family Presence During Resuscitation Efforts And Invasive Procedures Before And After An Educational Intervention., David Cross

Nursing Masters

Background: Since the 1980’s , family presence during resuscitation and invasive procedures has been supported in the literature as being beneficial to health care workers, family and patients. Ongoing controversy related to misconceptions regarding family practice hinder its acceptance and practice in the hospital setting. determine the effects of an educational Purpose : The purpose of this project was to intervention on nurses’ attitudes, beliefs, and intent to practice family presence using the adult learning theory and theory of reasoned action. Methods: Pre and post surveys were used in this study. Nurses in a local emergency department, who volunteered for …

Sunitinib Plus Paclitaxel Versus Bevacizumab Plus Paclitaxel For First-Line Treatment Of Patients With Advanced Breast Cancer: A Phase Iii, Randomized, Open-Label Trial, Nicholas Robert, Mansoor Saleh, Devchand Paul, Daniele Generali, Laurent Gressot, Mehmet Copur, Adam Brufsky, Susan Minton, Jeffrey Giguere, John W. Smith Ii

Haematology and Oncology, East Africa

Introduction: A multicenter, open-label phase III study was conducted to test whether sunitinib plus paclitaxel prolongs progression-free survival (PFS) compared with bevacizumab plus paclitaxel as first-line treatment for patients with HER2− advanced breast cancer.

Patients and Methods: Patients with HER2− advanced breast cancer who were disease free for ≥ 12 months after adjuvant taxane treatment were randomized (1:1; planned enrollment 740 patients) to receive intravenous (I.V.) paclitaxel 90 mg/m2 every week for 3 weeks in 4-week cycles plus either sunitinib 25 to 37.5 mg every day or bevacizumab 10 mg/kg I.V. every 2 weeks.

Results: The trial was terminated early …

Evaluation Of A Novel Non-Penetrating Electrode For Use In Dna Vaccination, Amy Donate, Domenico Coppola, Yolmari Cruz, Richard Heller

Bioelectrics Publications

Current progress in the development of vaccines has decreased the incidence of fatal and non-fatal infections and increased longevity. However, new technologies need to be developed to combat an emerging generation of infectious diseases. DNA vaccination has been demonstrated to have great potential for use with a wide variety of diseases. Alone, this technology does not generate a significant immune response for vaccination, but combined with delivery by electroporation (EP), can enhance plasmid expression and immunity. Most EP systems, while effective, can be invasive and painful making them less desirable for use in vaccination. Our lab recently developed a non-invasive …

Pedaling Alters The Excitability And Modulation Of Vastus Medialis H-Reflexes After Stroke, Dana P. Fuchs, Namita Sanghvi, Jon A. Wieser, Sheila Schindler-Ivens

Physical Therapy Faculty Research and Publications

Objective

Individuals post-stroke display abnormal Group Ia reflex excitability. Pedaling has been shown to reduce Group Ia reflexes and to normalize the relationship between EMG and reflex amplitude in the paretic soleus (SO). The purpose of this study was to determine whether these changes extend to the paretic quadriceps.

Methods

H-reflexes were used to examine Group Ia reflex excitability of the vastus medialis (VM). H-reflexes were elicited in paretic (n = 13) and neurologically intact (n = 13) individuals at 11 positions in the pedaling cycle and during static knee extension at comparable limb positions and levels of …

Effect Of Animal Facility Construction On Basal Hypothalamic-Pituitary-Adrenal And Renin-Aldosterone Activity In The Rat, Hershel Raff, Eric D. Bruder, William E. Cullinan, Dana R. Ziegler, Eric P. Cohen

Biomedical Sciences Faculty Research and Publications

Nearby construction can cause subtle, but important activation of the hypothalamic-pituitary-adrenal axis in laboratory rats.

Although loud noise and intense vibration are known to alter the behavior and phenotype of laboratory animals, little is known about the effects of nearby construction. We studied the effect of a nearby construction project on the classic stress hormones ACTH, corticosterone, renin, and aldosterone in rats residing in a barrier animal facility before, for the first 3 months of a construction project, and at 1 month after all construction was completed. During some of the construction, noise and vibrations were not obvious to investigators …

Development And Validation Of Liquid Chromatography Tandem Mass Spectrometry (Lc-Ms/Ms) Methods For The Analysis Of Veterinary Drugs In Various Biological And Feed Matrices Utilizing Efficient Extraction Protocols, Mark Cronly

Doctoral

The transfer of farming practices from low intensity farming systems for livestock production to commercial enterprises which employ intensive practices has resulted in the use of veterinary drugs becoming a critical component of food production. Resulting residues of veterinary drugs occurring in food of animal origin may give rise to potential health risks to consumers. The aim of this research is the development of analytical methods capable of screening and confirming increased number of these residues in more target matrices by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS). Its focus is the analysis of nitroimidazole residues in food of animal origin …

Balancing The Scale: Directions For Future Research For Perinatal Advanced Practice Nurses, Lisa Hanson, Leona Vandevusse, Heidi Paquette

College of Nursing Faculty Research and Publications

No abstract provided.

Quality And Cost Analysis Of Nurse Staffing, Discharge Preparation, And Postdischarge Utilization, Marianne E. Weiss, Olga Yakusheva, Kathleen Bobay

College of Nursing Faculty Research and Publications

Objectives. To determine the impact of unit-level nurse staffing on quality of discharge teaching, patient perception of discharge readiness, and postdischarge readmission and emergency department (ED) visits, and cost-benefit of adjustments to unit nurse staffing.

Data Sources. Patient questionnaires, electronic medical records, and administrative data for 1,892 medical–surgical patients from 16 nursing units within four acute care hospitals between January and July 2008.

Design. Nested panel data with hospital and unit-level fixed effects and patient and unit-level control variables.

Data Collection/Extraction. Registered nurse (RN) staffing was recorded monthly in hours-per-patient-day. Patient questionnaires were completed before discharge. Thirty-day readmission and ED …

Hepatocellular Carcinoma Survival In Uninsured And Underinsured Patients, John A Harvin, George Van Buren, Kuojen Tsao, Putao Cen, Tien C Ko, Curtis J Wray

Faculty, Staff and Student Publications

BACKGROUND: The incidence of hepatitis C virus (HCV) and hepatocellular carcinoma (HCC) is increasing. The purpose of this study is to establish baseline survival in a medically-underserved population and to evaluate the effect of HCV seropositivity on our patient population.

MATERIALS AND METHODS: We reviewed clinicopathologic parameters from a prospective tumor registry and medical records from the Harris County Hospital District (HCHD). Outcomes were compared using Kaplan-Meier survival analysis and log-rank tests.

RESULTS: A total of 298 HCC patients were identified. The median survival for the entire cohort was 3.4 mo. There was no difference in survival between the HCV …

Partial Volume Correction Incorporating Rb-82 Positron Range For Quantitative Myocardial Perfusion Pet Based On Systolic-Diastolic Activity Ratios And Phantom Measurements, Nils P Johnson, Stefano Sdringola, K Lance Gould

Faculty, Staff and Student Publications

BACKGROUND: Quantitative myocardial PET perfusion imaging requires partial volume corrections.

METHODS: Patients underwent ECG-gated, rest-dipyridamole, myocardial perfusion PET using Rb-82 decay corrected in Bq/cc for diastolic, systolic, and combined whole cycle ungated images. Diastolic partial volume correction relative to systole was determined from the systolic/diastolic activity ratio, systolic partial volume correction from phantom dimensions comparable to systolic LV wall thicknesses and whole heart cycle partial volume correction for ungated images from fractional systolic-diastolic duration for systolic and diastolic partial volume corrections.

RESULTS: For 264 PET perfusion images from 159 patients (105 rest-stress image pairs, 54 individual rest or stress images), …

A Behavioral Analysis Of Spatial Neglect And Its Recovery After Stroke, Jennifer Rengachary, Biyu J. He, Gordon L. Shulman, Maurizio Corbetta

Open Access Publications

No abstract provided.

Moving An Incisor Across The Midline: A Treatment Alternative In An Adolescent Patient, Jose A. Bosio, T. Gerard Bradley, Arthur F. Hefti

School of Dentistry Faculty Research and Publications

A 13-year-old sought treatment for a severely compromised maxillary left central incisor and an impacted fully developed left canine. Extraction of both teeth became necessary. As the key component of the revised comprehensive treatment plan, the right maxillary central incisor was moved into the position of the left central incisor. All other maxillary teeth were moved mesially to close any gaps. Active orthodontic treatment was completed after 34 months. Frenectomy, minor periodontal surgeries, and bonded lingual retainers were used to improve aesthetics and stabilize the tooth positions. The patient was pleased with the treatment outcome. Cone-beam computed tomography provided evidence …

Adoption Of Electronic Health Records By Admitting Physicians: A Heuristic Model, John Sharon Hudson

Health Services Research Dissertations

Background: Although hospital electronic health records (EHRs) are generally perceived to improve care, physician resistance may hinder EHR adoption.

Purpose: This study uses constructs from diffusion of innovations and resource dependence theories to predict adoption and rate of adoption of an EHR by admitting physicians from three of ten hospitals in a highly integrated health system in Virginia. Functions evaluated: computerized physician order entry (CPOE), electronic history and physical (EH&P) and electronic discharge summary (EDS). The study tested hypotheses that adoption would be associated with: working at larger, academic hospitals; financial alignment; larger physician groups; office EHR; youth; males; medical …

La Operación Y Estructura De Salud Familiar Comunitaria Intercultural En El Caso De Achocalla, Dominic Strada

Independent Study Project (ISP) Collection

Esta investigación se centra en la nueva política sanitaria del programa Salud Familiar Comunitaria Intercultural, su nueva administración y su aplicación en Bolivia. La Salud Familiar Comunitaria Intercultural es una política de salud social que décadas después del proceso de descentralización del poder ha puesto la responsabilidad sanitaria en manos de las comunidades. Este estudio se centra en las estructuras de Salud Familiar Comunitaria Intercultural desde el nivel municipal, hasta un total de ocho estructuras, en el municipio de Achocalla. Achocalla es un caso interesante ya que es a la vez una localidad urbana, por formar parte de los suburbios …

Riesgo De Exposición A Los Plaguicidas En Familias Con Niños Menores De 6 Años De Azapa Y Lluta, Andrew Wilbur

Independent Study Project (ISP) Collection

This study aims to characterize the risk of pesticide exposure for children under the age of 6 who live in the rural, agricultural communities of the Azapa and Lluta valleys in Region Arica and Parinacota in northern Chile. To achieve this objective, it seeks to understand current perceptions held by parents or guardians with respect to risk of pesticide exposure within their families and identify practices and living circumstances that contribute to this risk. In environmental health, children are an especially vulnerable population as a result of their distinct characteristics. Their exploratory behavior and naivety contribute to their risk of …

Reflexiones Sobre La Tristeza Y La Preocupación En Las Personas Aymara De Putre, Chile, Jordana Laks

Independent Study Project (ISP) Collection

Background: In the past decade, the issue of cultural competance has emerged as an important strategy for improving quality of health care. In northern Chile, home of the vast majority of the country’s Aymara indigenous population, efforts to promote cultural competance have led to greater recognition of traditional medicine and cooperation between Aymara healers and Chilean care providers. Success in this area depends on a comprehensive understanding of current health beliefs and practices in the Aymara community. While the traditional Aymara medical system has been well-researched, there is a lack of understanding of how the Aymara people perceive and treat …

Healing South Africa: The Institute For Healing Of Memories As A Lens For Post-Conflict Trauma Initiatives, Rachael C. Ward

Independent Study Project (ISP) Collection

This paper investigates how South Africa is attempting to deal with its violent past and present, by way of helping individuals cope with trauma. The Institute for Healing of Memories was examined through a case study and the Trauma Centre for Victims of Violence and Torture was also researched. I inquired first, what is most successful about these organizations’ work, and second, whether these successful approaches could be exported to help a larger percentage of traumatized people in South Africa. My research found that the entire Healing of Memory workshop methodology is successful and would need to be exported as …

Risk Factors Associated With Helicobacter Pylori Infection Treatment Failure In A High Prevalence Area., Javed Yakoob, Wasim Jafri, Z Abbas, Shahab Abid, S Naz, Khan R, A. B. Khalid

Section of Gastroenterology

Triple therapy is commonly used for the treatment of Helicobacter pylori infection. We determined risk factors associated with its failure in compliant patients focusing on H. pylori density, virulence marker and 23S ribosomal RNA (rRNA) point mutations associated with clarithromycin resistance. H. pylori infection was diagnosed by 14C urea breath test (14C UBT) and rapid urease test or histology. Triple therapy with esomeprazole 20 mg b.i.d., amoxicillin 1 g b.i.d. and clarithromycin 500 mg b.i.d. was prescribed for 10 days. 14C UBT was repeated 4 weeks after treatment. In total, 111 patients [69 (62%) males] with a mean age of …

Human Papillomavirus Genotype Concordance Within Zambian Couples, Kgomotso Makhaola

School of Biological Sciences: Dissertations, Theses, and Student Research

Human Papillomavirus (HPV) is strongly associated with the development of cervical cancer, and has also been identified in other anogenital cancers such as penile, oral, and anal cancers. In regions like Sub Saharan Africa where the prevalence of HIV/AIDS is high,   increased rates of HPV infections have also been observed, however the effect of HIV/AIDS on the transmission of HPV is not yet well understood.  In this study specimens for HIV, HPV testing and pathology were collected from male participants and their female partners at a Urology department in Lusaka University Teaching Hospital, Zambia. Seventy four samples were collected but …

Development Of Social Learning Program For Students In Undergraduate Deaf Rehabilitation Program Undergraduate Deaf Rehabilitation Program, Sandra Hansmann, Shawn P. Saladin, Sonia Quintero

School of Rehabilitation Services & Counseling Faculty Publications

Service-learning models have long since provided students the opportunities to connect with the community they will serve upon graduation. Valley-ICAN (Independent, Confident, Activities, Network) was developed to supplement a capstone practicum requirement for an undergraduate rehabilitation program with a concentration in services to individuals who are deaf or hard of hearing and to help reinforce the curriculum,by connecting the students to the deaf community and the service providers.This article describes the program and its benefits to the students and the community.

Triage In The Emergency Department: Role Challenges, Satisfaction, And Perceptions Of Staff, Jaclyn Gardner

Undergraduate Theses and Capstone Projects

The goal of this study is to describe staff satisfaction and role challenges among Registered Nurses (RN’s) and Emergency Department technicians in a 43 bed Emergency Department (ED) at a community hospital. This is an exploratory study to determine the factors that create an efficient ED, from staffs perspective, to facilitate improvement for other Emergency Departments. Four RN’s were interviewed, including at least one manager, and ED staff completed a survey to determine role challenges involved in the triage process, perceptions of qualifications needed for triage, and overall satisfaction with the comprehensive triage method used in this setting. Surveys were …

Access To Dental Care In Two Long-Term Refugee Camps In Western Tanzania; Programme Development And Assessment, Toni M. Roucka

School of Dentistry Faculty Research and Publications

Objective:  To analyse the demographics surrounding and the sustainability of a course in Emergency Dental Care and Health Promotion developed and taught by a team of dentists from the United States to refugee camp health-care workers in two long-term refugee camps in Western Tanzania.

Methods:  Refugee camp dental patient log books from Mtabila and Nyarugusu camps Kigoma, Tanzania were analysed and demographic data collected on each patient visit from the programme inception in November 2007 until August 2009. Data collection included information relevant to 1961 patient visits. Data were entered into SPSS Statistics 17.0 using the Freq application.

Outcomes:  Patient …

The Lived Experience Of Ovarian Cancer, Jennifer Tyll

Nursing Masters

It was estimated that in 2009,21,550 women would be diagnosed with ovarian cancer and 14.600 women would die from it. There are approximately 176,007 women living with ovarian cancer in the US. While there is extant quantitative - literature surrounding quality of life of women with ovarian cancer, there are significantly less qualitative studies. The purpose of this study was to explore the lived experience of how women with ovarian cancer perceived their quality of life. I Five women were interviewed. Interviews were tape recorded and transcribed, then I read for overall impression and general themes. Three major themes were …