Medicine and Health Sciences Commons^™

The Effects Of Rehabilitation Exercises In Community-Dwelling Elderly With Osteoarthritis And Stroke: A Pilot Study, Jia-Ching Chen, Chun-Hsiang Lin, Li-Chun Chen, Yu-Chun Wei, Jung Hsiao, Nan-Yueh Lin, Chung-Chao Liang

Rehabilitation Practice and Science

The prevalence of chronic disease in community-dwelling elderly has increased with the increase in the elderly population in Taiwan. This study investigated the effects of regular rehabilitation exercises provided by rehabilitation professionals in community-dwelling elderly people with osteoarthritis and stroke. A single group with pretest-posttest design was used in this pilot study. A total of 32 elderly people in the community were recruited and classified into two groups, one with osteoarthritis (n=21) and the other with chronic stroke (n=11). The intervention of one consisted of one 3-hour rehabilitation exercise session each week provided by a physical therapist and consultation with …

Carpal Tunnel Syndrome As An Initial Presentation Of Glioblastoma Multiforme: A Casereport, Chih-Hung Tseng, Kun-Lin Wu, Sin-Hao Ho, Su-Ju Tsai

Rehabilitation Practice and Science

A 43-year-old woman was clinically diagnosed as carpal tunnel syndrome due to the presentation of intermittent numbness, tingling and pain in her right thumb and index finger. The symptoms gradually exacerbated together with positive Phalen's test and Tinel's sign. Endoscopic carpal tunnel release procedure failed to relieve her symptoms. Ensuing symptoms developed such as headache, extensive numbness and mild weakness in her right upper and lower limbs. MRI of brain revealed a left thalamic tumor. Stereotactic biopsy confirmed the pathologic diagnosis as glioblastoma. Post-operative radiotherapy and temozolomide chemotherapy were performed to suppress disease progression. She also received comprehensive rehabilitation program, …

Posterior Interosseous Neuropathy Related To Cumulative Trauma Disorder: A Casereport, Cheng-Hao Tseng, Tsung-Cheng Huang, Jen-Wen Hung, Bin-Chi Chang

Rehabilitation Practice and Science

Work related cumulative posterior interosseous neuropathy is a rare cumulative trauma disorder. To the best of our knowledge, a locksmith with this kind of disorder has never been reported. The locksmith was a 57-year-old man, and he had to perform repeated supination and pronation movements when working. He complained of weakness of right third and fourth finger extension when typing on a computer keyboard. Radial deviation was also noted when his wrist was extended. Electromyography was performed and right posterior interosseous neuropathy was suspected. Magnetic resonance imaging (MRI) showed perineural muscle edema, obliteration and fluid accumulation at the level of …

Multiple Heterotopic Ossifications In A Patient With Traumatic Brain Injury And Femoral Fracture: A Casereport, Chun-Sheng Ho, Chein-Wei Chang, Eou-Ting Hsieh, Jen-Li Pan

Rehabilitation Practice and Science

Sporadic heterotopic ossification is a common complication in patients with spinal cord injury, traumatic brain injury, electrical burns, hip fracture, elbow fracture or total hip arthroplasty. However, multiple heterotopic ossifications in a traumatic brain injury case are quite rare. We report a case of a 23 year-old female patient with traumatic brain injury and a right femoral open fracture due to a traffic accident. She started to develop local erythema, swelling, warmth and pain over the left elbow and right hip about two months after the accident. The range of motion of the affected joints decreased and this severely impeded …

Early-Stage Myeloid Sarcoma Presenting As Back Pain In An Adolescent: A Casereport, Chao-Pin Yang, Shih-Chung Wang, Ta-Sen Wei, Sen-Yung Liu, Tsung-Ju Wu, Albert D. Yang

Rehabilitation Practice and Science

Myeloid sarcoma (MS) is a rare disease. MS is a malignant solid tumor resulting from the extramedullary proliferation of myeloblasts or immature myeloid cells.It is often described in association with acute myeloid leukemia (AML). In the absence of overt leukemia, MS is rarely considered in the differential diagnosis of a soft-tissue mass, and the diagnosis of MS is usually delayed or misdiagnosed. We present the case of a female adolescent who initially complained of back pain. Conservative treatment including medication and rehabilitation was given to her, but in vain, and the symptoms gradually progressed to severe neurological function loss, including …

Juvenile Muscular Amyotrophy Of Distal Upper Limbs: A Casereport, Tzu-Ying Sung, Shu-Fen Sun, Po-Chin Wang, Chiao-Wen Hwang, Jue-Long Wang

Rehabilitation Practice and Science

Juvenile muscular amyotrophy of distal upper limbs (Hirayama disease) is a rare disease predominantly affecting the anterior horn cells of the cervical cord in young men. It is a kind of cervical myelopathy characterized by insidious onset of unilateral distal dominant upper limbs muscle weakness and atrophy due to anterior cervical cord compression. It is difficult to differentiate this disease from other diseases with similar symptoms such as motor neuron disease. Cervical magnetic resonance (MR) study in flexed position is helpful to confirm the diagnosis.We reported a 21-year-old man who complained of slowly progressed muscle atrophy and weakness of right …

Evaluation Of Common Inherited Variants In Mitochondrial-Related And Microrna-Related Genes As Novel Risk Factors For Ovarian Cancer, Jennifer Permuth Wey

USF Tampa Graduate Theses and Dissertations

Epithelial ovarian cancer (EOC) is a leading cause of morbidity and mortality among women in the United States, and the etiology is incompletely understood. Common, low penetrant genetic variants such as single nucleotide polymorphisms (SNPs) likely contribute to a significant proportion of EOC. We examined whether SNPs in two understudied yet biologically important types of genes, mitochondrial-related and miRNA-related genes, may contribute to EOC susceptibility using data from a large, homogeneous study population of 1,815 EOC cases and 1,900 controls (frequency-matched on age-group and race/ethnicity) genotyped through stage 1 of an ongoing genome-wide association study. Inter-individual variation in genes involved …

Epidemiological Study Of Contributing Factors In The Development Of Peptic Ulcer And Gastric Cancer Initiated By Helicobacter Pylori Infection In India, Rahul Suresh Mhaskar

USF Tampa Graduate Theses and Dissertations

Background: Helicobacter pylori (H. pylori) infection is a significant risk factor for peptic ulcer (PU) and gastric cancer (GC). Apart from the virulent CagA genotype of H. pylori environmental and dietary factors influence disease outcomes. There have been no studies addressing these factors in Western India. Hence, we conducted a case control study enrolling PU, GC patients and controls at Pune, India.

Methods: Risk factors for PU and H. pylori infection were assessed in participant interview. H. pylori status was assessed from stool by monoclonal antigen detection. To understand treatment effect, we followed 100 H. pylori positive patients.

Results: We …

Dna Methylation And Its Association With Prenatal Exposures And Pregnancy Outcomes, Jennifer Straughen

USF Tampa Graduate Theses and Dissertations

Altered DNA methylation may lead to suboptimal fetal programming, increasing the risk of adverse pregnancy outcomes such as small for gestational age (SGA); however, few studies have examined the associations between DNA methylation, prenatal exposures, and fetal outcomes. Cross-sectional data from a larger, ongoing study were used to assess the impact of prenatal smoking on gene specific methylation of umbilical cord blood derived DNA and to investigate the association between gene-specific methylation and risk of SGA. The association between gene-specific DNA methylation and birthweight was also assessed. Maternal and infant covariates were abstracted from medical records, cigarette smoke exposure was …

The Mozambique Eyecare Programme – A Partnership Which Addresses Avoidable Blindness In Lusophone Africa, Aoife Phelan, James Loughman, Eva Doyle

Conference Papers

According to the WHO about 831 million people are visually impaired worldwide, 45 million of them are blind. Most people with visual impairment are older, and females are more at risk at every age, in every part of the world. Uncorrected Refractive Error accounts for over half of all visual impairment. About 87% of the worlds visually impaired live in developing countries. The Mozambique Eyecare Programme (MEP) is a cross institutional collaboration between governments, higher education institutions, non-governmental organisations and corporations. The aims of this Programme are to collaborate to provide a sustainable solution to the problem of avoidable blindness …

Pegylated Interferon Α-2b Up-Regulates Specific Cd8+ T Cells In Patients With Chronic Hepatitis B, Ji Chen, Yan Wang, Jun Li, Feng-Qin Hou, Gui-Qiang Wang

Pharmacology and Toxicology Faculty Publications

AIM: To investigate the effect of pegylated interferon (IFN) α-2b on specific CD8+ T lymphocytes in patients with chronic hepatitis B (CHB). METHODS: Twenty-one patients with CHB were treated with pegylated IFN α-2b. Periphery blood mononuclear cells were isolated from fresh heparinized blood by Ficoll-Hypaque density gradient centrifugation (density: 1.077 g/L, Pharmingen) at weeks 0, 4, 8, 12, and 24, respectively. Frequency of circulating hepatitis B virus (HBV) epitope-specific CD8 T cells was detected by flow cytometry. Cytokines were detected by cytometric bead assay. RESULTS: The frequency of circulating HBV core or env-specific CD8 T cells was higher (P …

Stem Cells For Spinal Cord Regeneration: Current Status, Zain A. Sobani, Syed A. Quadri, Ather Enam

Section of Neurosurgery

Background: Nearly 11,000 cases of spinal cord injury (SCI) are reported in the United States annually. Current management options give a median survival time of 38 years, however, no rehabilitative measures are available. Stem cells have been under constant research given their ability to differentiate into neural cell lines replacing non functional tissue. Efforts have been made to establish new synapses and provide a conducive environment, by grafting cells from autologous and fetal sources, including embryonic or adult stem cells, Schwann cells, genetically modified fibroblasts, bone stromal cells, and olfactory ensheathing cells and combinations/ variants thereof.
Methods: In order to …

Gangguan Akibat Kekurangan Yodium Pada Wanita Usia Subur Di Kecamatan Baturaden Kabupaten Banyumas, Jawa Tengah, Endo Dardjito, Setiyowati Rahardjo

Kesmas

Gangguan Akibat Kekurangan Yodium (GAKY) merupakan salah satu masalah gizi di Kabupaten Banyumas. GAKY disebabkan oleh defisiensi kronik asupan yodium, konsumsi goitrogenik, penggunaan kontrasepsi KB hormonal, faktor genetik, dan pengetahuan penderita. Prevalensi penyakit gondok di Kecamatan Baturaden, Kabupaten Banyumas, terus meningkat mencapai 35,38% pada tahun 2007 sehingga daerah ini tergolong endemis berat GAKY. Untuk menganalisis faktor-faktor risiko GAKY di Kecamatan Baturaden, suatu penelitian penjelasan dengan desain kasus kontrol telah dilakukan dengan melibatkan 30 orang wanita usia subur (15-45 tahun) yang menderita GAKY sebagai kasus dan 30 orang WUS lain yang tidak menderita GAKY sebagai sebagai kontrol. Kedua kelompok adalah penduduk …

Kontaminasi Bakteri Escherichia Coli Pada Makanan Pedagang Kaki Lima Di Sepanjang Jalan Margonda Depok, Jawa Barat, Dewi Susanna, Yvonne M. Indrawani, Zakianis Zakianis

Kesmas

Menteri Kesehatan menetapkan bahwa makanan dan minuman tidak boleh mengandung bakteri Escherichia coli (E. coli). Namun, kebanyakan pemerintah daerah tidak menindaklanjutinya dengan menerapkan peraturan yang lebih teknis untuk mencegah penyakit-penyakit yang ditularkan lewat makanan. Penelitian ini bertujuan untuk mengukur kontaminasi E. coli dalam makanan yang dijual oleh pedagang kaki lima (PKL). Seratus PKL di sepanjang Jalan Margonda Kota Depok, Jawa Barat, dipilih secara acak sebagai sampel. Sebanyak 100 PKL, E. coli pada sampel berbagai jenis makanan diukur dengan metode most probable number, sementara sanitasi PKL dan kehigienisan penjamah makanan diamati. Ditemukan secara umum bahwa air bersih yang digunakan untuk memasak, …

Analisis Ketahanan Hidup Lima Tahun Penderita Kanker Ovarium Epithelial Di Rumah Sakit Kanker Dharmais Jakarta, Indang Trihandini, Dieta Nurrika

Kesmas

Kanker ovarium merupakan salah satu penyebab utama kematian wanita. Dalam kasus kanker, jumlah serum albumin adalah indikator prognostik bertahan hidup yang penting, sementara probabilitas global pasien kanker ovarium dengan serum albumin ³ 3,6 g/dL dan ² 3,5 g/dL untuk bertahan hidup lima tahun masing-masing 23% and 10%. Namun di Indonesia, ketahanan hidup pasien-pasien kanker ovarium epithelial belum diteliti secara intensif. Penelitian yang dilaporkan ini bertujuan untuk menentukan probabilitas ketahanan hidup pasien-pasien kanker ovarium epithelial menurut tingkat serum albumin tertentu. Dengan menggunakan rancangan studi kohort retrospektif dan analisis ketahanan hidup, 48 orang pasien Rumah Sakit Kanker Dharmais Jakarta diamati sejak pertama …

Kualitas Hidup Anak Remaja Pada Keluarga Dengan Hiv/Aids Di Indonesia, Toha Muhaimin

Kesmas

Epidemi HIV/AIDS mempunyai dampak pada sosial ekonomi keluarga, terutama terhadap kualitas hidup anak remaja (12-18 tahun). Untuk melihat dampak HIV/AIDS dalam keluarga terhadap kualitas hidup remaja dan untuk mengidentifikasi berbagai faktor yang mempengaruhi besar dampak itu, telah dilakukan penelitian dengan menggunakan data survei tentang AIDS yang dikumpulkan tahun 2007 oleh Pusat Penelitian Kesehatan Universitas Indonesia. Variabel komposit yang terdiri variabel pendidikan, lingkungan sosial, dan aktivitas fisik, yang dikategorikan menjadi kurang baik dan baik, digunakan untuk mengukur kualitas hidup. Variabel-variabel ini kemudian dianalisis dengan regresi logistik untuk melihat besar dampak HIV/AIDS dalam keluarga, rumah tangga, dan anak terhadap kualitas hidup remaja. …

The Best Christmas Gift Of All, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Physician’S Ability To Manually Detect Isolated Elevation In Leg Intracompartmental Pressure., Franklin D. Shuler Md, Matthew J. Dietz

Orthopaedics

Background: Serial physical examination is recommended for patients for whom there is a high index of suspicion for compartment syndrome. This examination is more difficult when performed on an obtunded patient and relies on the sensitivity of manual palpation to detect compartment firmness—a direct manifestation of increased intracompartmental pressure. This study was performed to establish the sensitivity of manual palpation for detecting critical pressure elevations in the leg compartments most frequently involved in clinical compartment syndrome.

Methods: Reproducible, sustained elevation of intracompartmental pressure was established in fresh cadaver leg specimens. Pressures tested included 20 and 40 mm Hg (negative controls) …

Cast-Saw Burns: Evaluation Of Skin, Cast, And Blade Temperatures Generated During Cast Removal, Franklin D. Shuler Md, Frank N. Grisafi

Orthopaedics

Background: The use of an oscillating saw for cast removal creates a potential for iatrogenic injury and patient discomfort. Burns and abrasions can occur from the heat created by frictional forces and direct blade contact. With use of a cadaver model system, skin temperature measurements were recorded during cast removal with an oscillating saw.

Methods: Casts of uniform thickness were applied to cadavers equilibrated to body temperature. The casts were removed by a single individual while simultaneously measuring temperatures at the skin-padding interface, cast-padding interface, and the blade. Variables tested include two removal techniques, two casting materials (fiberglass and plaster), …

Phosphorylation Meets Nuclear Import: A Review., Jonathan D Nardozzi, Kaylen Lott, Gino Cingolani

Department of Biochemistry and Molecular Biology Faculty Papers

Phosphorylation is the most common and pleiotropic modification in biology, which plays a vital role in regulating and finely tuning a multitude of biological pathways. Transport across the nuclear envelope is also an essential cellular function and is intimately linked to many degeneration processes that lead to disease. It is therefore not surprising that phosphorylation of cargos trafficking between the cytoplasm and nucleus is emerging as an important step to regulate nuclear availability, which directly affects gene expression, cell growth and proliferation. However, the literature on phosphorylation of nucleocytoplasmic trafficking cargos is often confusing. Phosphorylation, and its mirror process dephosphorylation, …

The Impact Of An Aac Device, Using The Lamp Approach, Mary Hannah Pulliam

Student Theses and Dissertations

This investigation examined both the initial and renewed impact of an augmentative and alternative communication (AAC) device, using the Language Acquisition through Motor Planning (LAMP) approach, on an individual with autism spectrum disorder (ASD). A within subject research design was utilized and consisted of a multiple baseline across behavior design in combination with a multiple baseline across device research design.This investigation included one child with ASD, and utilized an observation checklist of video recordings (Appendix A) to assess the communication behaviors of the participant. The behaviors in question were communication acts per obligatory context per minute, the percent of total …

The Pseudomonas Aeruginosa Magnesium Transporter Mgte Inhibits Transcription Of The Type Iii Secretion System, Gregory G. Anderson, Timothy L. Yahr, Rustin R. Lovewell, George A. O'Toole

Dartmouth Scholarship

Pseudomonas aeruginosa is an opportunistic pathogen that causes life-long pneumonia in individuals with cystic fibrosis (CF). These long-term infections are maintained by bacterial biofilm formation in the CF lung. We have recently developed a model of P. aeruginosa biofilm formation on cultured CF airway epithelial cells. Using this model, we discovered that mutation of a putative magnesium transporter gene, called mgtE, led to increased cytotoxicity of P. aeruginosa toward epithelial cells. This altered toxicity appeared to be dependent upon expression of the type III secretion system (T3SS). In this study, we found that mutation of mgtE results in increased T3SS …

Mir-17* Suppresses Tumorigenicity Of Prostate Cancer By Inhibiting Mitochondrial Antioxidant Enzymes, Yong Xu, Fang Fang, Jiayou Zhang, Sajni Josson, William H. St. Clair, Daret K. St. Clair

Toxicology and Cancer Biology Faculty Publications

Aberrant micro RNA (miRNA) expression has been implicated in the pathogenesis of cancer. Recent studies have shown that the miR-17-92 cluster is overexpressed in many types of cancer. The oncogenic function of mature miRNAs encoded by the miR-17-92 cluster has been identified from the 5' arm of six precursors. However, the function of the miRNAs produced from the 3' arm of these precursors remains unknown. The present study demonstrates that miR-17* is able to suppress critical primary mitochondrial antioxidant enzymes, such as manganese superoxide dismutase (MnSOD), glutathione peroxidase-2 (GPX2) and thioredoxin reductase-2 (TrxR2). Transfection of miR-17* into prostate cancer PC-3 …

Self-Insurance And The Potential Effects Of Health Reform On The Small-Group Market, Kathryn Linehan

National Health Policy Forum

The Patient Protection and Affordable Care Act (PPACA) as amended by the Health Care Education Reconciliation Act of 2010 makes landmark changes to health insurance markets. Individual and small-group insurance plans and markets will see the biggest changes, but PPACA also affects large employer and self-insured plans by imposing rules for benefit design and health plan practices. Over half of workers—most often those in very large firms—are covered by self-insured health plans in which employers (or employee groups) bear all or some of the risk of providing insurance coverage to a defined population of workers and their dependents. As PPACA …

Formalizing A Conceptual Framework Of Work Domain Knowledge, Min Zhu

Dissertations and Theses (Open Access)

Background: The failure rate of health information systems is high, partially due to fragmented, incomplete, or incorrect identification and description of specific and critical domain requirements. In order to systematically transform the requirements of work into real information system, an explicit conceptual framework is essential to summarize the work requirements and guide system design. Recently, Butler, Zhang, and colleagues proposed a conceptual framework called Work Domain Ontology (WDO) to formally represent users’ work. This WDO approach has been successfully demonstrated in a real world design project on aircraft scheduling. However, as a top level conceptual framework, this WDO has not …

Feasibility Study Among Military Personnel With Traumatic Amputation During Military Combat Or Training, Michele (Shelly) R. Burdette-Taylor Phd, Msn, Rn-Bc, Cwcn, Cfcn

Dissertations

Military operations have resulted in a significant number of mangled extremities leading to traumatic amputations. Extremity injuries predominate, representing 50% to 70% of all injuries treated (Melcer, 2010). The majority of injuries sustained in Operation Endearing Freedom/Operation Iraqi Freedom (OEF/OIF) are combined penetrating, burn and blast injuries, traumatic amputation, and infections from the multi-drug resistant organism, Acinetobacter (Melcer, 2010). The purpose of this study was to measure the quality of well-being and impact of events in a group of adults who served in the U.S. armed forces and sustained the loss of one or more limbs during any combat or …

What Americans Can Learn From Sports Day In Canada?, Rick Burton, Norm O'Relly

Sport Management - All Scholarship

No abstract provided.

Perceptions Of Athletic Training Services At Ncaa Division Ii And Naia Institutions, Lawrence Antwan Reynolds

Student Theses and Dissertations

The purpose of this study was to evaluate satisfaction levels between injured collegiate student-athletes, their athletic trainers, and the services they provide during rehabilitation of musculoskeletal injuries. A secondary purpose was to determine the effect demographics and patient variables have on patient satisfaction within athletic environments. Exactly 82 collegiate student athletes competing in NAIA and NCAA Division II athletics completed an online survey used to assess levels of patient satisfaction with athletic trainers and athletic training. The findings of the study revealed that collegiate student-athletes attitudes towards athletic trainers and the services they provide were favorable across six components of …

Anxiety And Depression Among Outpatients With Type 2 Diabetes: A Multi-Centre Study Of Prevalence And Associated Factors., Ali Khan Khuwaja, Saima Lalani, Raheem Dhanani, Iqbal Syed Azam, Ghazala Rafique, Franklin White

Department of Family Medicine

Background: Anxiety and depression contribute to poor disease outcomes among individuals with diabetes. This study aimed to assess the prevalence of anxiety and depression and to identify their associated factors including metabolic components among people with type 2 diabetes. Methods: We conducted a cross-sectional, multi-center study in four out-Patient clinics in Karachi, Pakistan. In all, 889 adults with type-2 diabetes were included in this study. Anxiety and depression were measured by using the Hospital Anxiety and Depression Scale (HADS). Multivariable analysis using multiple logistic regression was carried out to evaluate the combined effect of various factors associated with anxiety and …

Medical School Watercooler Newsletter - December 19, 2010, Lindsey Lyle

Watercooler Newsletter

This is the December 19, 2010 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• North Drive Closed Through Jan. 2
• Students Donate Books to USA Pediatric Clinics Through Reach Out and Read Program
• Mark Your Calendars: Gumbo Chili Showdown
• USA Library Hosts "DepARTmental" Art Exhibition
• USA Neurologist Speaks at AANEM 57th Annual Meeting in Quebec City