Medicine and Health Sciences Commons^™

Dna Methylation And Its Association With Prenatal Exposures And Pregnancy Outcomes, Jennifer Straughen

USF Tampa Graduate Theses and Dissertations

Altered DNA methylation may lead to suboptimal fetal programming, increasing the risk of adverse pregnancy outcomes such as small for gestational age (SGA); however, few studies have examined the associations between DNA methylation, prenatal exposures, and fetal outcomes. Cross-sectional data from a larger, ongoing study were used to assess the impact of prenatal smoking on gene specific methylation of umbilical cord blood derived DNA and to investigate the association between gene-specific methylation and risk of SGA. The association between gene-specific DNA methylation and birthweight was also assessed. Maternal and infant covariates were abstracted from medical records, cigarette smoke exposure was …

Evaluation Of Common Inherited Variants In Mitochondrial-Related And Microrna-Related Genes As Novel Risk Factors For Ovarian Cancer, Jennifer Permuth Wey

USF Tampa Graduate Theses and Dissertations

Epithelial ovarian cancer (EOC) is a leading cause of morbidity and mortality among women in the United States, and the etiology is incompletely understood. Common, low penetrant genetic variants such as single nucleotide polymorphisms (SNPs) likely contribute to a significant proportion of EOC. We examined whether SNPs in two understudied yet biologically important types of genes, mitochondrial-related and miRNA-related genes, may contribute to EOC susceptibility using data from a large, homogeneous study population of 1,815 EOC cases and 1,900 controls (frequency-matched on age-group and race/ethnicity) genotyped through stage 1 of an ongoing genome-wide association study. Inter-individual variation in genes involved …

Epidemiological Study Of Contributing Factors In The Development Of Peptic Ulcer And Gastric Cancer Initiated By Helicobacter Pylori Infection In India, Rahul Suresh Mhaskar

USF Tampa Graduate Theses and Dissertations

Background: Helicobacter pylori (H. pylori) infection is a significant risk factor for peptic ulcer (PU) and gastric cancer (GC). Apart from the virulent CagA genotype of H. pylori environmental and dietary factors influence disease outcomes. There have been no studies addressing these factors in Western India. Hence, we conducted a case control study enrolling PU, GC patients and controls at Pune, India.

Methods: Risk factors for PU and H. pylori infection were assessed in participant interview. H. pylori status was assessed from stool by monoclonal antigen detection. To understand treatment effect, we followed 100 H. pylori positive patients.

Results: We …

Formalizing A Conceptual Framework Of Work Domain Knowledge, Min Zhu

Dissertations & Theses (Open Access)

Background: The failure rate of health information systems is high, partially due to fragmented, incomplete, or incorrect identification and description of specific and critical domain requirements. In order to systematically transform the requirements of work into real information system, an explicit conceptual framework is essential to summarize the work requirements and guide system design. Recently, Butler, Zhang, and colleagues proposed a conceptual framework called Work Domain Ontology (WDO) to formally represent users’ work. This WDO approach has been successfully demonstrated in a real world design project on aircraft scheduling. However, as a top level conceptual framework, this WDO has not …

Feasibility Study Among Military Personnel With Traumatic Amputation During Military Combat Or Training, Michele (Shelly) R. Burdette-Taylor Phd, Msn, Rn-Bc, Cwcn, Cfcn

Dissertations

Military operations have resulted in a significant number of mangled extremities leading to traumatic amputations. Extremity injuries predominate, representing 50% to 70% of all injuries treated (Melcer, 2010). The majority of injuries sustained in Operation Endearing Freedom/Operation Iraqi Freedom (OEF/OIF) are combined penetrating, burn and blast injuries, traumatic amputation, and infections from the multi-drug resistant organism, Acinetobacter (Melcer, 2010). The purpose of this study was to measure the quality of well-being and impact of events in a group of adults who served in the U.S. armed forces and sustained the loss of one or more limbs during any combat or …

Perceptions Of Maternal Stress And Neonatal Patient Outcomes In A Single Private Room Versus Open Room Neonatal Intensive Care Unit Environment., Lisa M. Smithgall

Electronic Theses and Dissertations

Limited clinical evidence exists regarding whether the single private room Neonatal Intensive Care Unit (NICU) environment of care delivery has a positive, negative, or neutral impact on health outcomes for the high risk neonate and on maternal stress as compared to the open room design. The study purpose was to examine whether a difference exists in health outcomes in the open room versus single private room NICU environment. The factors considered were weight gain, ventilator days, hospital length of stay, incidence and grade of intraventricular hemorrhage (IVH), the number of parental visits, and perceptions of maternal stress. Infants hospitalized in …

The Effect Of Sternocleidomastoid Muscle Activation Pattern And Feedback Condition On The Vestibular Evoked Myogenic Potential., Mary Jo Davenport

Electronic Theses and Dissertations

The vestibular evoked myogenic potential (VEMP) has been shown to be clinically useful in providing diagnostic information regarding the function of the otolith receptors, inferior vestibular nerve, and vestibulospinal pathways. The VEMP is a biphasic response elicited by loud clicks or tone bursts and recorded from the tonically contracted sternocleidomastoid (SCM) muscle. Because the VEMP is an inhibitory response, it is important to investigate stimulus and parameter characteristics in order to determine the optimal test protocol and maximize clinical usefulness. The aims of this study were 1) to evaluate the effects of 4 different methods of SCM muscle activation and …

The Influence Of Neurocognitive Impairment On Treatment Outcomes Among Drug-Involved People Living With Hiv/Aids, Ifeoma O. Ezeabogu

Master's Theses

Drug- and sex-related HIV risk behaviors and sub-optimal adherence to HIV medication regimens can jeopardize the health of HIV–infected injection drug users (IDUs) and threaten community health. Findings to date indicate that it is feasible to deliver a brief behavioral risk reduction/medication adherence group intervention to HIV-infected IDUs in a community-based setting. Being adherent to HAART or being able to successfully participate in behavioral interventions targeting adherence and harm reduction often requires a relatively high level of cognitive abilities. HIV infection and substance abuse are known to independently affect the central nervous system and this can result in neuro-cognitive impairment. …

3000 Steps In 30 Minutes, Five Days Per Week Yields Metabolic Improvements Compared To 150 Weekly Minutes, Valerie Ann Lambert

Masters Theses, 2010-2019

The physical activity recommendation for U.S. adults is to engage in moderate-intensity exercise for at least 150 minutes per week. Pedometers have gained popularity as a tool for motivating and estimating daily physical activity. Recently it was suggested 3000 steps in 30 minutes may be equivalent to moderate-intensity walking. To date, this recommendation has yet to be examined over an extended period of time. PURPOSE: To evaluate changes in cardiorespiratory fitness, body composition, blood lipids, blood glucose, and CRP from 150 minutes of free living weekly exercise compared to pedometer measured 3000 steps in 30 minutes, five days per week. …

Mathematical Modeling, Simulation, And Time Series Analysis Of Seasonal Epidemics., Eric Shu Numfor

Electronic Theses and Dissertations

Seasonal and non-seasonal Susceptible-Exposed-Infective-Recovered-Susceptible (SEIRS) models are formulated and analyzed. It is proved that the disease-free steady state of the non-seasonal model is locally asymptotically stable if R_v < 1, and disease invades if R_v > 1. For the seasonal SEIRS model, it is shown that the disease-free periodic solution is locally asymptotically stable when R̅_v < 1, and I(t) is persistent with sustained oscillations when R̅_v > 1. Numerical simulations indicate that the orbit representing I(t) decays when R̅_v < 1 < R_v. The seasonal SEIRS model with routine and pulse vaccination is simulated, and results depict an unsustained decrease …

Von Willebrand Factor Expression In Vascular Endothelial Cells Of Cage Control And Antiorthostatic Cage Suspension Golden Hamster Ovaries., Kristan Provchy

Undergraduate Honors Theses

The hamster estrous cycle lasts four days and is considered to be a physiological model for angiogenesis. Angiogenesis is the formation of new capillaries from preexisting vessels, and it occurs extensively during corpus luteum formation in the estrous cycle. Von Willebrand Factor (vWF) is a glycoprotein that is secreted uniquely in endothelial cells and megakaryocytes. It is frequently used as an endothelial cell marker and it is able to detect vessels within tissues when it is used in immunohistochemical staining techniques. This study explores von Willebrand Factor expression within Golden Hamster ovarian tissue. In particular, this study uses cage control …

African American Adolescents At Risk: Their Stories Revealed Through Dance/Movement Therapy, Alicia Marie Williams

Creative Arts Therapies Theses

The purpose ofthis study was originally to support the voices of African American adolescents and the emergence of their stories through the use of mentors hip, dance/movement therapy, and the production of an artistic performance. But what I truly found was that through parallel processing this study turned into an artistic inquiry that helped me uncover more insight about my own story: a story ofloss, isolation, rejection, recovery, independence, support and acceptance, and confidence.

As a result of the artistic inquiry I was able to see the value of my knowledge from integrating my experiences. I developed confidence in my …

A Stakeholder Generated Conceptualization For Successful Return To Work Outcome Evaluation: A Concept Mapping Approach, Rhysa Leyshon

Electronic Thesis and Dissertation Repository

Measurement of return to work (RTW) lacks attention to outcomes of relevance to all stakeholders. The objective of this thesis was to define what constitutes a successful RTW outcome from a stakeholder perspective and determine how to best measure it. A concept mapping method was used to create a conceptualization of successful RTW outcome based on indicators of interest and importance to various stakeholders. RTW researchers were questioned and the literature was searched for measures that mapped to the conceptualization and concepts. Stakeholders, made up of RTW consumers and providers, generated 48 indicators of successful RTW which were subsequently grouped …

Improvements In Cardiac Spect/Ct For The Purpose Of Tracking Transplanted Cells, Eric Sabondjian

Electronic Thesis and Dissertation Repository

Regenerative therapy via stem cell transplantation has received increased attention to help treat the myocardial injury associated with heart disease. Currently, the hybridisation of SPECT with X-ray CT is expanding the utility of SPECT. This thesis compared two SPECT/CT systems for attenuation correction using slow or fast-CT attenuation maps (mu-maps). We then developed a method to localize transplanted cells in relation to compromised blood flow in the myocardium following a myocardial infarction using SPECT/CT. Finally, a method to correct for image truncation was studied for a new SPECT/CT design that incorporated small field-of-view (FOV) detectors. Computer simulations compared gated-SPECT reconstructions …

Cigar Crisis: The Need For Community Based Practices, Christopher D. Watson

Public Health Theses

Considerable evidence exists that little cigars and cigarillos are popular among young adults and that the prevalence is higher among African American young adults.1,2,4 Two brands of little cigars appear most appealing to young smokers - Swisher Sweets and Black and Mild.2,3 This cigar product have been designed by the tobacco industry to appeal specifically for African Americans. In a survey of tobacco use among freshman at a historically black university, there were high rates of little cigar use.4 Little cigar sales have also benefited from the high visibility offered by many celebrities quoted and photographed with cigars, and the …

Mapping The Flip Angle In Magnetic Resonance Imaging Using The Accelerated 3d Look-Locker Sequence, Trevor P. Wade

Electronic Thesis and Dissertation Repository

In the ongoing quest to extract more information from MRI images, there has arisen a need to rapidly map the flip angle. This has been primarily driven by the shift to stronger main field strengths, which bring with them improved SNR, but also new difficulties. In particular, the radio frequency field used to excite the magnetization can no longer be assumed uniform at field strengths of 3 Tesla and above. New rapid quantitative imaging techniques, such as DESPOT1 and DESPOT2, rely on accurate knowledge of the flip angle, and while this could safely be assumed to be the prescribed value …

A Geographical Examination Of Social, Behavioral, And Demographic Determinants Association With Hepatitis C Viral Infection In The State Of Georgia, Terran A. Terrell

Public Health Theses

Background: Approximately 170 million persons are infected with the hepatitis C viral infection (HCV), globally. Of this number, 3.2 – 4 million persons in the U. S. are infected with HCV. Although previous research has indicated a decrease in the rates of Hepatitis C in the U.S. approximately 12,000 deaths occur annually from those who suffer from chronic liver disease, as a result of being chronic carriers of HCV. Being a recipient of blood transfusions prior to 1992, intravenous drug users (IDUs), or persons with multiple sex partners are associated with increased risk for HCV infection. IDUs constitute the largest …

The Effect Of Different Interfaces On Aerosol Delivery In Simulated Spontaneously Breathing Adult With Tracheostomy, Alaa Ahmed Bugis

Respiratory Therapy Theses

Background: The delivery of an aerosol via a tracheostomy tube has been previously described with both a tracheostomy collar and a T-piece, but not with a Wright mask, or aerosol mask. The primary purpose of this study was to quantify lung doses using different interfaces: tracheostomy collar, Wright mask, and aerosol mask. The secondary purposes were to compare albuterol delivery between an opened vs. a closed fenestration hole and also to determine the effect of inspiratory time:expiratory time (I:E) ratio on aerosol delivery.

Methods: A teaching mannequin (Medical Plastic Labs, Gatesville, TX) with a tracheostomy opening was used. Two of …

Effectiveness Of A Pre-Release Planning Program For Hiv-Positive Offenders Exiting Georgia Prisons: A Qualitative Evaluation Approach, Claire A. Willeford

Public Health Theses

Background: Two-year nationwide prison recidivism rates stand at over 60%, and minorities and the poor are at greatest risk both of first-time incarceration and of offending repeatedly over time. Initiatives that may address prison inmates’ lack of resources and increase their success in their communities after release are now an important topic in the study of criminal justice policy. Over the course of the past two decades, the public health concern of HIV/AIDS has increasingly become a part of this discourse on re-entry, as the disease disproportionately affects minority communities both in and outside of prisons. Affected reentrants face not …

Elevated Bmi-Associated Characteristics Of Patients With Invasive Mrsa Infection In The Atlanta, Georgia Metro Area, 2005-2008, Lauren R. Lorentzson

Public Health Theses

INTRODUCTION: National obesity rates are leading to higher rates of Type 2 Diabetes, increasing the number of people at risk of invasive infections with Methicillin Resistant Staphylococcus aureus (iMRSA) upon onset of ESRD and hemodialysis. However, an association between adiposity and risk of iMRSA has not been researched. AIM: The purpose of this study is to describe the epidemiological characteristics of an iMRSA cohort in the Atlanta metro area between 2005-2008; to examine BMI-related health outcomes within the cohort; and to compare proportions of BMI categories in this cohort to BRFSS data. METHODS: Surveillance data collected by the CDC EIP …

The Effects Of A Single Session Of Dance/Movement Therapy With Adults In Crisis Stabilization: A Mixed Methods Study, Ashley Duquette

Creative Arts Therapies Theses

The purpose of this thesis is to identify the effects of a single session of dance/movement therapy (DMT) for crisis stabilization with adults in a short-term residential facility. Over the course of 14 weeks (14 sessions) surveys were administered before and after each session to participants who were new to the group. These surveys, along with the researcher’s observations and written notes about the group were collected in order to gain information about the participants’ experience of symptoms and wellbeing before and after the group. The change in symptoms and wellbeing was analyzed quantitatively and qualitatively through the use of …

Comparison Of Albuterol Delivery Between High Frequency Oscillatory Ventilation And Conventional Mechanical Ventilation In A Simulated Adult Lung Model Using Different Compliance Levels, Waleed A. Alzahrani

Respiratory Therapy Theses

COMPARISON OF ALBUTEROL DELIVERY BETWEEN HIGH FREQUENCY OSCILLATORY VENTILATION AND CONVENTIONAL MECHANICAL VENTILATION IN A SIMULATED ADULT LUNG MODEL USING DIFFERENT COMPLIANCE LEVELS By Waleed A. Alzahrani, BSRT BACKGROUND: Delivery of aerosol by pMDI has been described with conventional mechanical ventilation (CMV) but not with high frequency oscillatory ventilation (HFOV). The purpose of this study was to compare aerosol delivery to a simulated 75 kg adult with low compliance during both CMV and HFOV. Since actuation of pMDI with inspiration is not feasible with HFOV, we investigated the impact of actuation timing only during CMV. METHOD: CMV (Respironics Esprit) and …

A Systematic Review Examining The Added Value Of Water, Sanitation, And Hygiene Interventions For Preventive Chemotherapy Programs On Reducing The Prevalence Of Trachoma, Anyess R. Travers

Public Health Theses

BACKGROUND: Trachoma is a leading cause of avoidable blindness. Currently, trachoma is endemic in 57 countries, infects approximately 84 million people globally, and continues to threaten over 10 % of the world’s population with the risk of blindness. Caused by the bacteria Chlamydia trachomatis, blindness due to trachoma is caused by repeated eye infection resulting in the inflammation of the upper eyelid eventually leading the upper lid to pull inward scratching and tearing the cornea causing it to become opaque resulting in loss of vision. The World Health Organization recommends eliminating trachoma as a public health problem using the SAFE …

A Proposal For Enhancing And Measuring Infant-Directed Maternal Utterances And Incidental Teaching Within The Safecare® Parent-Infant Interaction Module, Megan O. Smith

Public Health Theses

Child maltreatment is a serious and pervasive public health problem in the United States. In 2008, there were 772,000 children who were substantiated victims of maltreatment and 1,740 children died as a result of maltreatment. Approximately 33 percent of maltreatment victims were under the age of four. Among numerous other negative sequelae, children who have been maltreated have an elevated incidence of language delay and poor cognitive functioning, both strong predictors of literacy skills and later academic achievement. Further, maternal language input is critical to a child’s cognitive development and language acquisition. Maltreating mothers provide their children with far less …

The Effects Of Age And Heterochromatin On Frequencies Of Acquired Chromosomal Aneuploidy In Uncultured Human Leukocytes, Noran Aboalela

Theses and Dissertations

While age-related sex chromosomal aneuploidy is a well-characterized phenomenon, the relationship between autosomal loss and age remains unclear. The emergence of the specific and highly sensitive fluorescence in situ hybridization (FISH) technology has enabled investigators to study interphase cells, thereby overcoming problems inherent with the study of metaphase spreads for acquired aneuploidy assessment. Despite all the advantages of this technique, there are some limitations that could be misleading when scoring interphase autosomal aneuploidy. In this study we show that sex chromosomal hypoploidy is correlated with age. By using a twin study design, we evaluated Y chromosome hypoploidy frequencies and found …

Gastroesophageal Reflux Disease In Neonates And Infants: A Systematic Review To Identify Best Practice For Treatment, Kristen M. Mckinnon

Regis University Student Publications (comprehensive collection)

Many infants have some form of gastroesophageal reflux (GER) characterized by occasional spitting up with burps. Symptomatic reflux called gastroesophageal reflux disease (GERD) affects infants and causes a variety of symptoms and observable events. The diagnosis of GER or GERD appears to be increasing in the infant population including healthy newborns and those infants hospitalized for a variety of reasons. The purpose of this systematic review is to identify evidence-based practice guidelines for the treatment of GERD, including pharmacologic and non-pharmacologic interventions in the neonatal/infant population. The results of this study show that conservative therapies should be used initially in …

Personal Factors, Perceptions, Influences And Their Relationship With Adherence Behaviors In Patients With Diabetes, Glenn E. Hagerstrom

Nursing Dissertations (PhD)

Problem and significance: Adherence to health-promoting behaviors in a diabetes self-care regimen is essential for individuals with diabetes and can assist providers and individuals with diabetes management. The purpose of this research was to explore the relationship between personal factors (age, length of diabetes diagnosis, perceived health status, weight), perceived barriers to action (number of barrier days), interpersonal influences (social support), situational influences (depressive symptoms), and patient adherence to health-promoting behaviors (blood glucose monitoring, diet, and exercise) and health outcomes ( A1c and body mass index) in a diabetes self-care regimen.

Methods: A descriptive correlational analysis was performed using baseline …

The Relationship Of Personal Characteristics, Behavorial Capability, Environmental Factors, And Hypertension Medication Adherence In African American Adults With Metabolic Syndrome, Karen Andrea Armstrong

Nursing Dissertations (PhD)

Disparities in medication adherence (MA) associated with African American (AA) adults may be related to a dynamic interplay between personal factors, behavioral capability, and environmental factors. The purpose of the study was to examine this relationship in AA adults with metabolic syndrome (MetS). A cross-sectional, correlational analysis was conducted from baseline data from a larger intervention study. Constructs from the Social Cognitive Theory were used to predict MA. The sample of 91 AA adults with MetS was primarily middle-aged (age range 45-70 years old; M 53, SD 6.3), female (79%), relatively well-educated, and married. Despite being on antihypertensive medications, 53% …

The Effects Of Pattern Recognition Based Simulation Scenarios On Symptom Recognition Of Myocardial Infarction, Critical Thinking, Clinical Decision-Making, And Clinical Judgment In Nursing Students, Susan A. Walsh

Nursing Dissertations (PhD)

In the United States nearly 1 million annual new and recurrent myocardial infarctions (MI) occur with 10% of patients hospitalized with MI having unrecognized ischemic symptoms. Inexperienced nurses are expected to accurately interpret cardiac symptom cues, possibly without ever having experienced care of patients with MI, yet have been shown to be less able to classify symptom cues and reach accurate conclusions than experienced nurses. The purpose of this study was to test an educational intervention using theories of pattern recognition to develop CT in MI and improve nursing students’ clinical decision-making and clinical judgment using high fidelity patient simulation. …

An Evaluation Of Cardiorespiratory Responses And Ventilatory Efficiency During Treadmill And Cycling Exercise In Overweight Adolescents, Amanda Scheps

Theses and Dissertations

The assessment of ventilatory efficiency (VE/VCO2 slope) is increasingly being utilized to complement traditional cardiorespiratory fitness testing during graded exercise. The purpose of this study was to compare cardiorespiratory responses and ventilatory efficiency in obese children during a progressive exercise test to volitional fatigue performed on a treadmill and a cycle ergometer. Fifteen obese male (N=3) and female (N=12) adolescents aged 10 to 18 years were recruited in the study and completed both the treadmill and cycle ergometer trials. Mean age and BMI of the sample was 13.3 years and 38.0 kg/m2, respectively. Maximal oxygen consumption (VO2max) and ventilatory efficiency …