Medicine and Health Sciences Commons^™

Von Willebrand Factor Expression In Vascular Endothelial Cells Of Cage Control And Antiorthostatic Cage Suspension Golden Hamster Ovaries., Kristan Provchy

Undergraduate Honors Theses

The hamster estrous cycle lasts four days and is considered to be a physiological model for angiogenesis. Angiogenesis is the formation of new capillaries from preexisting vessels, and it occurs extensively during corpus luteum formation in the estrous cycle. Von Willebrand Factor (vWF) is a glycoprotein that is secreted uniquely in endothelial cells and megakaryocytes. It is frequently used as an endothelial cell marker and it is able to detect vessels within tissues when it is used in immunohistochemical staining techniques. This study explores von Willebrand Factor expression within Golden Hamster ovarian tissue. In particular, this study uses cage control …

3000 Steps In 30 Minutes, Five Days Per Week Yields Metabolic Improvements Compared To 150 Weekly Minutes, Valerie Ann Lambert

Masters Theses, 2010-2019

The physical activity recommendation for U.S. adults is to engage in moderate-intensity exercise for at least 150 minutes per week. Pedometers have gained popularity as a tool for motivating and estimating daily physical activity. Recently it was suggested 3000 steps in 30 minutes may be equivalent to moderate-intensity walking. To date, this recommendation has yet to be examined over an extended period of time. PURPOSE: To evaluate changes in cardiorespiratory fitness, body composition, blood lipids, blood glucose, and CRP from 150 minutes of free living weekly exercise compared to pedometer measured 3000 steps in 30 minutes, five days per week. …

The Influence Of Neurocognitive Impairment On Treatment Outcomes Among Drug-Involved People Living With Hiv/Aids, Ifeoma O. Ezeabogu

Master's Theses

Drug- and sex-related HIV risk behaviors and sub-optimal adherence to HIV medication regimens can jeopardize the health of HIV–infected injection drug users (IDUs) and threaten community health. Findings to date indicate that it is feasible to deliver a brief behavioral risk reduction/medication adherence group intervention to HIV-infected IDUs in a community-based setting. Being adherent to HAART or being able to successfully participate in behavioral interventions targeting adherence and harm reduction often requires a relatively high level of cognitive abilities. HIV infection and substance abuse are known to independently affect the central nervous system and this can result in neuro-cognitive impairment. …

Perceptions Of Maternal Stress And Neonatal Patient Outcomes In A Single Private Room Versus Open Room Neonatal Intensive Care Unit Environment., Lisa M. Smithgall

Electronic Theses and Dissertations

Limited clinical evidence exists regarding whether the single private room Neonatal Intensive Care Unit (NICU) environment of care delivery has a positive, negative, or neutral impact on health outcomes for the high risk neonate and on maternal stress as compared to the open room design. The study purpose was to examine whether a difference exists in health outcomes in the open room versus single private room NICU environment. The factors considered were weight gain, ventilator days, hospital length of stay, incidence and grade of intraventricular hemorrhage (IVH), the number of parental visits, and perceptions of maternal stress. Infants hospitalized in …

Mathematical Modeling, Simulation, And Time Series Analysis Of Seasonal Epidemics., Eric Shu Numfor

Electronic Theses and Dissertations

Seasonal and non-seasonal Susceptible-Exposed-Infective-Recovered-Susceptible (SEIRS) models are formulated and analyzed. It is proved that the disease-free steady state of the non-seasonal model is locally asymptotically stable if R_v < 1, and disease invades if R_v > 1. For the seasonal SEIRS model, it is shown that the disease-free periodic solution is locally asymptotically stable when R̅_v < 1, and I(t) is persistent with sustained oscillations when R̅_v > 1. Numerical simulations indicate that the orbit representing I(t) decays when R̅_v < 1 < R_v. The seasonal SEIRS model with routine and pulse vaccination is simulated, and results depict an unsustained decrease …

The Effect Of Sternocleidomastoid Muscle Activation Pattern And Feedback Condition On The Vestibular Evoked Myogenic Potential., Mary Jo Davenport

Electronic Theses and Dissertations

The vestibular evoked myogenic potential (VEMP) has been shown to be clinically useful in providing diagnostic information regarding the function of the otolith receptors, inferior vestibular nerve, and vestibulospinal pathways. The VEMP is a biphasic response elicited by loud clicks or tone bursts and recorded from the tonically contracted sternocleidomastoid (SCM) muscle. Because the VEMP is an inhibitory response, it is important to investigate stimulus and parameter characteristics in order to determine the optimal test protocol and maximize clinical usefulness. The aims of this study were 1) to evaluate the effects of 4 different methods of SCM muscle activation and …

African American Adolescents At Risk: Their Stories Revealed Through Dance/Movement Therapy, Alicia Marie Williams

Creative Arts Therapies Theses

The purpose ofthis study was originally to support the voices of African American adolescents and the emergence of their stories through the use of mentors hip, dance/movement therapy, and the production of an artistic performance. But what I truly found was that through parallel processing this study turned into an artistic inquiry that helped me uncover more insight about my own story: a story ofloss, isolation, rejection, recovery, independence, support and acceptance, and confidence.

As a result of the artistic inquiry I was able to see the value of my knowledge from integrating my experiences. I developed confidence in my …

Today - December 17, 2010, Loma Linda University

TODAY

Inside this issue:

-- Camp Good Grief offers bereaved kids and teens a chance to heal
-- Study takes ischemic pre-conditioning to new heights
-- Nutrition students granted Nestlé Foundation research funds
-- The study of forensic bite marks
-- Public health alumna appointed to air pollution agency
-- Faculty from allied health and medicine honored as Harvard Macy Scholars
-- Medicine professor discusses AIDS with community group
-- 'Conversations with authors' continues with December program
-- School of Public Health partners with United Way
-- Loma Linda University opens Center for Dentistry and Orthodontics
-- Physical therapy students begin …

Racial Disparities In Healthcare: Challenges Faced By Hispanic Populations, Kaitlin Mcdowell

Honors Projects

No abstract provided.

H-Ns Binding And Repression Of The Ctx Promoter In Vibrio Cholerae, Emily A. Stonehouse, Robin R. Hulbert, Melinda B. Nye, Karen Skorupski, Ronald K. Taylor

Dartmouth Scholarship

Expression of the ctx and tcp genes, which encode cholera toxin and the toxin coregulated pilus, the Vibrio cholerae O1 virulence determinants having the largest contribution to cholera disease, is repressed by the nucleoid-associated protein H-NS and activated by the AraC-like transcriptional regulator ToxT. To elucidate the molecular mechanism by which H-NS controls transcription of the ctxAB operon, H-NS repression and binding were characterized by using a promoter truncation series, gel mobility shift assays, and DNase I footprinting. Promoter regions found to be important for H-NS repression correlated with in vitro binding. Four main H-NS binding regions are present at …

Psychiatric Comorbidity In Transformed Migraine: Presentation, Treatment, Impact And Outcome, Muhammad A. Abbas M.D, Haseeba Ismaiel, M.D, William B. Young M.D., Mary Hopkins, Stephen D. Silberstein, M.D

Jefferson Journal of Psychiatry

Transformed migraine is one of the subtypes of chronic daily headache (CDH), and is similar to chronic migraine, described in the new International Headache Society (IHS) classification 2004. The term CDH refers to the Headache disorders experienced 15 or more days a month and includes headaches associated with medication overuse. CDH can be divided into primary and secondary varieties. Primary CDH is not related to a structural or systemic illness. It includes diseases such as Transformed migraine (TM). Chronic tension-type headache (CTTH), new daily persistent headache (NDPH), and hemicrania continua (HC). Secondary CDH has an identifiable underlying cause, including post-traumatic …

Resident Teaching Expectations And Medical Student Feedback, Michael Ignatowski

Jefferson Journal of Psychiatry

Objective Much of resident teaching of medical students occurs in an informal manner, with bedside teaching a common focus. Hence, the ability to monitor such teaching is limited. Feedback about how students perceive the teaching is perhaps one way to more effectively monitor and influence resident teaching.

Ten Year Follow Up Of A Psychiatry Residency Program Merger, Alvi A. Azad, Julianne Flynn, Thomas Matthews, Kenneth Matthews, Joseph Chozinski

Jefferson Journal of Psychiatry

Objective: To report on the successful merger of a civilian and military psychiatry residency. Methods: The reasons for and the history of the merger between the University of Texas Health Science Center at San Antonio and Wilford Hall Air Force Medical Center psychiatry residencies is described. Results: After some false starts, a bottom-up approach was implemented by first merging seminars, then rotations. Conclusions: Combining two psychiatry residencies in order to capitalize on both their strengths can yield a product even greater than the sum of their two programs and the key to a lasting merger is to start with two …

2010 Newsmakers: Celebrating Our Own, Paul Mayne, Jason Winders

Data and Test Instruments

How will we remember 2010? Probably through these faces. This year, the Western News starts a new, if not wholly original, tradition. Our Newsmakers 2010 section celebrates the best of research, academia and volunteer spirit that we have to offer on this campus. We spotlight, in brief words and striking images, the accomplishments of some of our favourites from the last year. One of the most powerful women in Canada. A student with an eye for the greater good. And a man who would do anything, including posing with a zebra, for the United Way. A football coach. A ground-breaking …

The Mission Of A Lifetime, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

A Simple Method To Reduce Infection Of Ventriculoperitoneal Shunts Clinical Article, Atiq-Ur Rehman, Tausif-Ur Rehman, Hassaan H. Bashir, Vikas Gupta

Department of Medicine

Object: Postoperative shunt infection is the most common and feared complication of ventriculoperitoneal (VP) shunt placement for treatment of hydrocephalus. The rate of shunt infection is highest in the 1st postoperative month. The most common organisms responsible for shunt infection include coagulase-negative Staphylococcus and Staphylococcus aureus. This suggests a transfer of Patient's skin flora via the surgeons' glove as a possible means of infection. The authors conducted a study to determine if the rate of postoperative shunt infections could be reduced simply by changing gloves before handling the shunt catheter. Methods: A total of 111 neonates born with congenital hydrocephalus …

The Effects Of A Single Session Of Dance/Movement Therapy With Adults In Crisis Stabilization: A Mixed Methods Study, Ashley Duquette

Creative Arts Therapies Theses

The purpose of this thesis is to identify the effects of a single session of dance/movement therapy (DMT) for crisis stabilization with adults in a short-term residential facility. Over the course of 14 weeks (14 sessions) surveys were administered before and after each session to participants who were new to the group. These surveys, along with the researcher’s observations and written notes about the group were collected in order to gain information about the participants’ experience of symptoms and wellbeing before and after the group. The change in symptoms and wellbeing was analyzed quantitatively and qualitatively through the use of …

Patient Perceptions Of Physician Empathy, Satisfaction With Physician, Interpersonal Trust, And Compliance, Mohammadreza Hojat, Daniel Z. Lewis, Kaye Maxwell, Fred Markham, Richard Wender, Joseph S. Gonnella

Department of Psychiatry and Human Behavior Faculty Papers

Objectives: This study was designed to investigate psychometric properties of the Jefferson Scale of Patient Perceptions of Physician Empathy (JSPPPE), and to examine correlations between its scores and measures of overall satisfaction with physicians, personal trust, and indicators of patient compliance.

Methods: Research participants included 535 out-patients (between 18-75 years old, 66% female). A survey was mailed to participants which included the JSPPPE (5-item), a scale for measuring overall satisfaction with the primary care physician (10-item), and demographic questions. Patients were also asked about compliance with their physician's recommendation for preventive tests (colonoscopy, mammogram, and PSA for age and gender …

Communities, Birth Attendants And Health Facilities: A Continuum Of Emergency Maternal And Newborn Care (The Global Network's Emonc Trial), Omrana Pasha, Robert L. Goldenberg, Elizabeth M. Mcclure, Sarah Saleem, Shivaprasad S. Goudar, Fernando Althabe, Archana Patel, Fabian Esamai, Ana Garces, Elwyn Chomba, Manolo Mazariegos, Bhala Kodkany, Jose M. Belizan, Richard J. Derman, Patricia L. Hibberd, Waldemar A. Carlo, Edward A. Liechty, K. Michael Hambidge, Pierre Buekens, Dennis Wallace, Lisa Howard-Grabman, Suzanne Stalls, Marion Koso-Thomas, Alan H. Jobe, Linda L. Wright

Community Health Sciences

Background: Maternal and newborn mortality rates remain unacceptably high, especially where the majority of births occur in home settings or in facilities with inadequate resources. The introduction of emergency obstetric and newborn care services has been proposed by several organizations in order to improve pregnancy outcomes. However, the effectiveness of emergency obstetric and neonatal care services has never been proven. Also unproven is the effectiveness of community mobilization and community birth attendant training to improve pregnancy outcomes. Methods/Design: We have developed a cluster-randomized controlled trial to evaluate the impact of a comprehensive intervention of community mobilization, birth attendant training and …

Salicylic Acid Diminishes Staphylococcus Aureus Capsular Polysaccharide Type 5 Expression, Lucia P. Alvarez, Maria S. Barbagelata, Mariana Gordiola, A. L. Cheung

Dartmouth Scholarship

Capsular polysaccharides (CP) of serotypes 5 (CP5) and 8 (CP8) are major Staphylococcus aureus virulence factors. Previous studies have shown that salicylic acid (SAL), the main aspirin metabolite, affects the expression of certain bacterial virulence factors. In the present study, we found that S. aureus strain Reynolds (CP5) cultured with SAL was internalized by MAC-T cells in larger numbers than strain Reynolds organisms not exposed to SAL. Furthermore, the internalization of the isogenic nonencapsulated Reynolds strain into MAC-T cells was not significantly affected by preexposure to SAL. Pretreatment of S. aureus strain Newman with SAL also enhanced internalization into MAC-T …

Uterine Epithelial Cell Regulation Of Dc-Sign Expression Inhibits Transmitted/Founder Hiv-1 Trans Infection By Immature Dendritic Cells, Daniel O. Ochiel, Christina Ochsenbauer, John C. Kappes, Mimi Ghosh, John V. Fahey, Charles R. Wira

Dartmouth Scholarship

Background:

Sexual transmission accounts for the majority of HIV-1 infections. In over 75% of cases, infection is initiated by a single variant (transmitted/founder virus). However, the determinants of virus selection during transmission are unknown. Host cell-cell interactions in the mucosa may be critical in regulating susceptibility to infection. We hypothesized in this study that specific immune modulators secreted by uterine epithelial cells modulate susceptibility of dendritic cells (DC) to infection with HIV-1.

Methodology/Principal Findings:

Here we report that uterine epithelial cell secretions (i.e. conditioned medium, CM) decreased DC-SIGN expression on immature dendritic cells via a transforming growth factor beta (TGF-β) …

The Ingredients Of Change: A Political Ecology Approach To Diabetes In The Somali Community Of Minnesota, Mina Tehrani

Geography Capstone Projects

In the early 1990’s, due to political circumstances at home, Somali immigrants and refugees began arriving in the state of Minnesota in large numbers. Over the past two decades, Somali immigrants have come to comprise one of the most populous ethnic groups in the Twin Cities, and are the largest Somali population in the world outside of Eastern Africa. Although quantitative data is unavailable, qualitative evidence and testimonies of healthcare professionals support the conclusion that Somali immigrants in Minnesota suffer from higher rates of diabetes than non-immigrant groups and than they likely did before migration. Why might this be the …

Ada News - 12/13/2010, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Gastroesophageal Reflux Disease In Neonates And Infants: A Systematic Review To Identify Best Practice For Treatment, Kristen M. Mckinnon

Regis University Student Publications (comprehensive collection)

Many infants have some form of gastroesophageal reflux (GER) characterized by occasional spitting up with burps. Symptomatic reflux called gastroesophageal reflux disease (GERD) affects infants and causes a variety of symptoms and observable events. The diagnosis of GER or GERD appears to be increasing in the infant population including healthy newborns and those infants hospitalized for a variety of reasons. The purpose of this systematic review is to identify evidence-based practice guidelines for the treatment of GERD, including pharmacologic and non-pharmacologic interventions in the neonatal/infant population. The results of this study show that conservative therapies should be used initially in …

Conformation Dependent Monoclonal Antibodies Distinguish Different Replicating Strains Or Conformers Of Prefibrillar Aβ Oligomers, Rakez Kayed, Isabel Canto, Leonid Breydo, Suhail Rasool, Tamas Lukacsovich, Jessica Wu, Ricardo Albay, Anna Pensalfini, Stephen Yeung, Elizabeth Head, J. Lawrence Marsh, Charles Glabe

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Age-related neurodegenerative diseases share a number of important pathological features, such as accumulation of misfolded proteins as amyloid oligomers and fibrils. Recent evidence suggests that soluble amyloid oligomers and not the insoluble amyloid fibrils may represent the primary pathological species of protein aggregates.

RESULTS: We have produced several monoclonal antibodies that specifically recognize prefibrillar oligomers and do not recognize amyloid fibrils, monomer or natively folded proteins. Like the polyclonal antisera, the individual monoclonals recognize generic epitopes that do not depend on a specific linear amino acid sequence, but they display distinct preferences for different subsets of prefibrillar oligomers. Immunological …

Evaluation Of Be Wise About Your Portion Size: A Nutrition Education Program For Floridians, Andrea C. Goosen, Laura K. Guyer, Linda B. Bobroff

Florida Public Health Review

In the U.S., obesity is recognized as a growing epidemic whose increased prevalence among adults, children and adolescents present major health concerns. It is the second leading cause of preventable death, surpassed only by tobacco use. Research indicates that controlling the portion sizes of food is an effective way to lose and maintain weight loss. The nutrition education program, “Be Wise about Your Portion Size (BWPS),” was developed in 2005 by the Florida Interagency Food and Nutrition Committee (FIFNC) to support the efforts of community-based nutrition educators. The resource manual provides background information about obesity, consumer handouts, and lesson plans …

The Efficacy Of A Supplementary Literacy Program For Kindergarten Children With Language Impairment, Amy E. Mckinney

Student Theses and Dissertations

The purpose of this study was to determine the efficacy of a supplemental literacy program for children with language impairment. Ten kindergarten children that qualified for language therapy at a kindergarten center were divided into treatment and non-treatment groups. Children in the treatment group participated in 10 minutes of supplemental literacy instruction at the end of each language intervention session. The non-treatment group received language therapy without the supplemental literacy intervention. Mid-term scores indicated a significant between group difference in letter-sound correspondence, but not in word decoding and sight word recognition for children in the treatment condition. Twelve week post …

The Effects Of Age And Heterochromatin On Frequencies Of Acquired Chromosomal Aneuploidy In Uncultured Human Leukocytes, Noran Aboalela

Theses and Dissertations

While age-related sex chromosomal aneuploidy is a well-characterized phenomenon, the relationship between autosomal loss and age remains unclear. The emergence of the specific and highly sensitive fluorescence in situ hybridization (FISH) technology has enabled investigators to study interphase cells, thereby overcoming problems inherent with the study of metaphase spreads for acquired aneuploidy assessment. Despite all the advantages of this technique, there are some limitations that could be misleading when scoring interphase autosomal aneuploidy. In this study we show that sex chromosomal hypoploidy is correlated with age. By using a twin study design, we evaluated Y chromosome hypoploidy frequencies and found …

Translating Hemoglobin A1c Scores Across An Ethnically Diverse Population: Is The Language Consistent Across All Races?, Corliss M. Allen, Eartha S. Butler, Joseph Negusei, Celeste Hart, Ivette A. López, Cynthia M. Harris, Penny Ralston

Florida Public Health Review

Hemoglobin A1c testing is an accepted measure of how well the blood glucose level has been controlled in the recent past (six to eight weeks) among individuals with diabetes. The purpose of this study was to evaluate the relationship between hemoglobin A1c (HbA1c) and blood glucose in an ethnically diverse population in a clinical setting. A cross-sectional research design was employed to explore associations between these two diabetes control measures in a sample of African American, White and Hispanic patients receiving diabetes treatment and follow-up in an outpatient clinic in Tallahassee, Florida. Data collection included a questionnaire, medical examinations, and …

Awake Vs. Asleep Placement Of Spinal Cord Stimulators: A Cohort Analysis Of Complications Associated With Placement, Steven M. Falowski, Md, Amanda Celii Md, Anthony K. Sestokas Phd, Daniel M. Schwartz Phd, Craig Matsumoto Mpas, Ashwini Sharan Md

Department of Neurosurgery Faculty Papers

Introduction: Patients will typically undergo awake surgery for permanent implantation of SCS in an attempt to optimize electrode placement using patient feedback about the distribution of stimulation-induced paresthesia. The present study compared efficacy of first-time electrode placement under awake conditions with that of neurophysiologically-guided placement under general anesthesia.

Methods: A retrospective review was performed of 387 SCS surgeries among 259 patients which included 167 new stimulator implantation to determine whether first time awake surgery for placement of spinal cord stimulators is preferable to non-awake placement.

Results: The incidence of device failure for patients implanted using neurophysiologically-guided placement under general anesthesia …