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Acknowledgements, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Flight Physician - December, 2010, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A sixteen page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

Out Of The Frying Pan, Into The Fire: Trauma In The Lives Of Homeless Youth Prior To And During Homelessness, John Coates, Sue Mckenzie-Mohr

The Journal of Sociology & Social Welfare

Anecdotal evidence from those who work with homeless youth indicates that trauma permeates these young people's lives. This paper presents the findings from a study of 100 homeless youth regarding the presence of trauma in their lives, both before and during homelessness. Participants living in the Maritime Provinces volunteered to take part in a semi-structured interview lasting one to two hours. The interview questionnaire was conducted by a trained interviewer, and was composed of standardized and adapted survey instruments, as well as questions regarding demographics, experiences prior to becoming homeless, assistance received while dealing with stressors, and current needs. The …

The Multilevel, Multicultural, And Multi-Temporal Ecosocial Framework Of Population Health : How Neighborhoods, Culture, And History Impact Health Outcomes And Produce Health Disparities, Lawrence Tarves Brown

Theses and Dissertations (ETD)

According to findings in the field of genetics, it has now been established that the impact of race on health is mostly a function of a people's lived experience, not their genetic make-up. Due to this, the role of race in the study of health outcomes and health disparities has traditionally been specified improperly in statistical models due to confounding with ethnicity. Additionally, the role of geography or the impact of neighborhoods on health is often not specified properly.

Thus, the author proposes a multilevel, multicultural, and multi-temporal ecosocial framework that explains the impact of neighborhoods on health and the …

Development And Evaluation Of Paclitaxel-Loaded Liposomal Formulations For Targeted Drug Delivery To Breast Cancer, Vinayagam Kannan

Theses and Dissertations (ETD)

The objective of this work was to develop and evaluate paclitaxel-loaded liposomal formulations for targeted drug delivery to breast cancer. The liposomal formulation was optimized to maximize drug loading and physical stability. Cholesterol and saturated lipid content showed a negative influence on paclitaxel loading. Short-term stability studies showed that optimum drug-lipid ratio is necessary for adequate physical stability. Biodistribution studies in mouse xenografts bearing MDA-MB-231 breast cancer using near infrared fluorescence imaging showed that the accumulation of tumor vasculature targeted long-circulating liposomes (LCL) in the tumor was significantly less than non-targeted LCL at 48 h. The accumulation of these liposomes …

The Development And Psychometric Testing Of A Hypertension Knowledge Instrument In A Vulnerable Population, Crescent Elayne Rowell

Theses and Dissertations (ETD)

The primary objective of the study was to assess the psychometric properties of a hypertension knowledge instrument in a vulnerable population. The secondary objective was to determine the association between hypertension knowledge and outcomes such as systolic and diastolic blood pressure and hemoglobin A1c.

A cross-sectional study was conducted using a convenience sample of 196 adults aged 18 years and older with hypertension. Item analysis was conducted to determine the reliability of the instrument. The factor structure was determined and confirmed using exploratory factor analysis and confirmatory factor analysis, respectively. Logistic regression analysis was used to determine the association between …

A Needs Assessment Of Cancer Survivors At Fox Chase Cancer Center (Abstract), Bonnie Mcintosh, Stacie Metz, Andrea Barsevick

Public Health Sciences Faculty Publications

No abstract provided.

Evaluation Of Quality And Patient Satisfaction During Endoscopic Procedure: A Cross Sectional Study From South Asian Country, Shahid Rasool, Shahid Ahmed, Shaheer Siddiqui, Mohammad Salih, Wasim Jafri, Saeed Hamid

Section of Gastroenterology

OBJECTIVE: To assess the quality of gastrointestinal (GI) endoscopic procedures and patient satisfaction in endoscopy suite of South Asian country.

METHODS: Patients coming to the endoscopic suite of Aga Khan University Hospital (AKUH) were interviewed and assessed in this cross-sectional study. Quality of GI endoscopic procedures was evaluated using assessment tools as suggested by The American Society of Gastroenterology. Patient satisfaction after the procedure was assessed using a modified GHAA-9 questionnaire. The questionnaire was statistically evaluated using Pareto analysis and Spearman rank correlation.

RESULTS: In this study, 323 patients were evaluated with a mean age of 43 +/- 14.36 years. …

Notes From The Director, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Mcnair Scholars Program, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Friends Of The Library Mcnair Scholarship Awards, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Further Validation Of The Body-Mind-Spirit Wellness Behavior And Characteristic Inventory For College Students, Nicole Mareno, Kathy Shadle James

Faculty Articles

Health promotion is a vital component of college health programs. College health professionals are challenged to find cost-effective, comprehensive measures to assess wellness and risk behaviors. Hettler’s 1979 Six Dimension of Wellness Model guided this inquiry. Physical, emotional, intellectual, occupational, social, and spiritual wellness dimensions were measured by the Body-Mind-Spirit Wellness Behavior and Characteristic Inventory (BMS-WBCI). This study aimed to further validate the BMS-WBCI by reporting reliability as internal consistency of the scale when used to measure wellness in a sample of college students. A descriptive cross-sectional design was utilized. A convenience sample of 106 college students from a small, …

The Association Of Religiosity, Sexual Education, And Parental Factors With Risky Sexual Behaviors Among Adolescents And Young Adults, Kristin Haglund, Richard J. Fehring

College of Nursing Faculty Research and Publications

This study examined the association of religiosity, sexual education and family structure with risky sexual behaviors among adolescents and young adults. The nationally representative sample, from the 2002 National Survey of Family Growth, included 3,168 women and men ages 15–21 years. Those who viewed religion as very important, had frequent church attendance, and held religious sexual attitudes were 27–54% less likely to have had sex and had significantly fewer sex partners than peers. Participants whose formal and parental sexual education included abstinence and those from two-parent families were 15% less likely to have had sex and had fewer partners.

Health Care In The United States: A Right Or Commodity?, Aaron Lloyd

Honors Projects

No abstract provided.

Women As Subject And Audience In World War Ii Venereal Disease Posters, Kyra Whitton

Dissertations, Theses and Capstone Projects

Internationally, venereal disease first became a major health concern during World War I. Venereal diseases were some of the most common infections and led to more hospitalizations among soldiers than wounds or battle-related illness. The Selective Service discovered that almost fifteen percent of those who were eligible for the draft were already infected with a venereal disease, sparking an intense anti-venereal disease campaign across America. Red-light districts were shut down, and American cities sought new laws that would criminalize prostitution to protect young men from contracting a venereal infection.

Though venereal disease rates were still high during World War II, …

Hydroxyurea And Acute Painful Crises In Sickle Cell Anemia: Effects On Hospital Length Of Stay And Opioid Utilization During Hospitalization, Outpatient Acute Care Contacts, And At Home, Samir K. Ballas, Md, Facp, Robert L. Bauserman, Phd, William F. Mccarthy, Phd, Oswaldo L. Castro, Md, Wally R. Smith, Md, Myron A. Waclawiw, Phd

Department of Medicine Faculty Papers

Recurrent acute sickle cell painful crises are the hallmark of sickle cell anemia. These events may be mild, moderate or severe in nature and often require treatment at home, in acute care facilities as outpatients, and in the hospital with oral and/or parenteral opioids. The type, dose, route & frequency of administration of opioids, as well as the length of hospital stay (LOS), are not well known for adults with sickle cell anemia (SS). We analyzed these aspects in the 299 patients enrolled in the Multicenter Study of Hydroxyurea (MSH) in SS. For these patients there were 16818 home diaries, …

Eight Simple Rules For Talking With Preschoolers, Rhea Paul

Communication Disorders Faculty Publications

The article offers eight simple rules that teachers can use to help preschoolers build their vocabularies. It suggests teachers to talk with children to identify topics that interest them. It also recommends teachers to accompany all the routines and activities of the preschool day to enhance the language experience of children. Moreover, it proposes that open-ended questions invites preschoolers to offer lengthier and more detailed responses, thus stimulating their language growth.

Long-Term Hypoxia Regulates Cortisol Biosynthesis In The Ovine Fetal Adrenal Cortex, Vladimir Enrique Vargas

Loma Linda University Electronic Theses, Dissertations & Projects

Previous studies demonstrated enhanced fetal adrenal cortisol biosynthesis following exposure to long-term hypoxia (LTH). The studies presented here were designed to determine the mechanism(s) regulating this important adaptive endocrine response. Ewes were maintained at high altitude (3,820 m) from approximately day 40 to 138-141 of gestation. Fetal adrenal glands were then collected from LTH and age matched normoxic controls. Dispersed fetal adrenal cortical cells (FACs) were untreated, treated with ACTH, treated in combination with ACTH precursors (POMC and 22-kDa pro-ACTH), or pre-treated with H-89 and or UO126 followed by ACTH treatment. Following ACTH treatment, cortisol biosynthesis increased in both groups …

Cerebral Amyloid Angiopathy And Transition Metals In Alzheimer's Disease, Matthew Schrag

Loma Linda University Electronic Theses, Dissertations & Projects

Alterations in brain metals homeostasis and particularly brain iron overload have been postulated to play a role in Alzheimer's disease, contributing to oxidative stress and neuronal injury; however, the source of this iron is not clear and may be due to metabolic derangement(s), failed iron clearance mechanisms or exogenous deposition such as through bleeding. This series of studies was designed to evaluate the extent of metals dyshomeostasis in the Alzheimer's disease brain and specifically whether microvascular bleeding is a major contributor to Alzheimer's disease-related iron overload. Cerebral amyloid angiopathy (CAA) is a vascular manifestation of Alzheimer's disease present to some …

Coronary Heart Disease Mortality And Long-Term Exposure To Ambient Particulate Air Pollutants In Elderly Nonsmoking California Residents, Lie Hong Chen

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study is to assess the effect of long-term concentrations of ambient PM on risks of all causes, cardiopulmonary, coronary heart disease (CHD), total cancer, and any mention of nonmalignant respiratory disease (NMRD) mortality.

The health effects of long-term ambient air pollution have been studied with up to 30 years of follow-up in the AHSMOG cohort, a cohort of 6,338 nonsmoking white California adults. Monthly concentrations of ambient air pollutants [particulate matter(PMio), Ozone (O3), sulfur dioxide (SO2), nitrogen dioxide (NO2) or particulate matter

In the AHSMOG cohort, each increment of 10 |ig/m3 in PMio in two-pollutant models …

The Role Of Ambient Air Pollution In The Occurrence Of Emphysema, Shiva Metghalchi

Loma Linda University Electronic Theses, Dissertations & Projects

Emphysema is the most common cause of death from respiratory disease in the United States. Emphysema is most common among people aged 50 and older. Those with a genetic predisposition to emphysema may experience the onset as early as their thirties or forties. Men are more likely than women to develop emphysema, but female cases are increasing as the number of female smokers rises.

In the past few years, etiological and pathogenic research has been carried out in an attempt to determine the reason for an increase in deaths and other health problems associated with air pollution, and there have …

Effects Of Acculturation On Hiv/Aids Sexual Risk Behaviors Among Asian And Pacific Islander (Api) Women, Margaret Cabotage Salud

Loma Linda University Electronic Theses, Dissertations & Projects

Background. In the US women are the fastest growing group for sexually transmitted infections (STIs), including HIV and AIDS. In addition, the estimated AIDS cases among female adults and adolescents, aged 13-19, increased from 7% in 1985 to approximately 26% in 2002. Most infections occur by heterosexual transmission with 53% occurring through contact with a high-risk sexual partner. While overall HIV/AIDS rates in the Asian Pacific Islander (API) community remain low, they are rising and HIV testing rates, one of the major prevention strategies for HIV, are lower than that of other populations. Furthermore, very little is known about APIs …

New To Ols For Monitoring Gamma Camera Uniformity, Brad K. Lofton

Dissertations and Theses (Open Access)

Detector uniformity is a fundamental performance characteristic of all modern gamma camera systems, and ensuring a stable, uniform detector response is critical for maintaining clinical images that are free of artifact. For these reasons, the assessment of detector uniformity is one of the most common activities associated with a successful clinical quality assurance program in gamma camera imaging. The evaluation of this parameter, however, is often unclear because it is highly dependent upon acquisition conditions, reviewer expertise, and the application of somewhat arbitrary limits that do not characterize the spatial location of the non-uniformities. Furthermore, as the goal of any …

Analysis Of Β8 Integrin In Neurogenesis And Neurovascular Homeostasis, Aaron K. Mobley

Dissertations and Theses (Open Access)

Neurogenesis in the adult mouse brain occurs within the subventricular zone (SVZ) of the lateral ventricle. In the SVZ, neural stem cells (NSC) reside in a specialized microenvironment, or vascular niche, consisting of blood vessels and their basement membranes. Most NSCs in the SVZ differentiate into progenitor cells, which further differentiate to generate neuroblasts, which then migrate from the SVZ to the olfactory bulbs (OB) along the rostral migratory stream (RMS). ECM-mediated adhesion and signaling within the vascular niche likely contribute to proper NSC self-renewal, survival, differentiation and neuroblast motility. The mechanisms that control these events are poorly understood. Previous …

Anencephaly: Concepts Of Personhood, Ethical Questions, And Nursing Care, Jessica L. Ryskamp

Senior Honors Theses

Anencephaly is a neural tube defect that severely limits the lifespan of affected infants. While these infants have no higher brain function, they are still persons, and should be given the same moral and ethical considerations as healthy infants. With this in mind, organ donation procedures should follow the same guidelines that apply to other donors. Because a large part of nursing care for anencephalic infants is palliative care, nurses need appropriate training to care effectively for both the infant and the family, providing for physical, emotional, psychological, and spiritual needs.

Exhausted Or Unlicensed: Can Field-Of-Use Restrictions In Biotech License Agreements Still Prevent Off-Label Use Promotion After Quanta Computer?, Kristal M. Wicks

The University of New Hampshire Law Review

[Excerpt] “In the biotechnology (biotech) industry, companies must be increasingly aware of their intellectual property and how their licensing strategies can impact their rights. When licensing patented technology, it is common practice for biotech companies to include restricted field-of-use provisions in their license agreements. Such provisions permit a licensee to only use licensed technology in a defined field and restrict use or development in another field. This licensing strategy plays an important role within the biotech industry because it allows companies to more effectively control their intellectual property and to more efficiently research and develop pharmaceutical products.

A problem that …

The Parents' Role In Childhood Obesity, Heather M. Wintrup

Psychology and Child Development

This paper is an examination of the current childhood obesity crisis in the U.S. and how this epidemic is related to psychological issues. Specifically, the role of parental forces on children’s health attitudes and habits is addressed. The following chapters will define and explain the current situation of childhood obesity, investigate the role parents have in contributing to their children’s weight development, and cover methods of intervention for families dealing with this serious health issue.

Epigenetic Regulation Of Neuronal Maturation: The Effect Of Mecp2 And Micrornas On The Maturation Of Hippocampal Neurons, Richard D. Smrt

Biomedical Sciences ETDs

Dendrites and the dendritic spines of neurons play key roles in the connectivity of the brain and have been recognized as the locus of long-term synaptic plasticity, which is correlated with learning and memory. The development of dendrites and spines in the mammalian central nervous system is a complex process that requires specific molecular events over a period of time. It has been shown that specific molecules are needed not only at the spines point of contact, but also at a distance, providing signals that initiate a cascade of events leading to synapse formation. The specific molecules that act to …

Characterization Of The Sero-Reactivity Of Proteins Map1152 And Map1156 From Mycobacterium Avium Subspecies Paratuberculosis, Avery L. Paulson

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Mycobacterium avium subsp. paratuberculosis (MAP) causes Johne’s disease (JD) in ruminants. Development of genetic tools and completion of the MAP genome sequencing project expanded opportunities for antigen discovery. In this thesis, I review the current trends in diagnosis and disease control of JD and present the results of the studies on the seroreactivity of two proteins encoded for by the MAP1152-MAP1156 gene cluster. MAP1152 encodes for a PPE protein and MAP1156 encodes a diacylglycerol acyltransferase involved in triglyceride metabolism and classified in the uncharacterized protein family UPF0089. Maltose-binding protein (MBP) tagged recombinant MAP proteins were purified from Escherichia coli. …

Staphylococcus Aureus Virulence Factors Synthesis Is Controlled By Central Metabolism, Yefei Zhu

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Staphylococcus aureus is a versatile pathogen that can survive in diverse host environments. This versatility depends on its ability to sense nutrients and respond by modulating gene expression, including the synthesis of virulence determinants. In addition to its ability to synthesize virulence factors, the capacity of S. aureus to form biofilms is an important mediator of virulence in certain infections. Biofilms are a complex aggregation of bacteria commonly encapsulated by an adhesive exopolysaccharide matrix (polysaccharide intercellular adhesin; PIA). To study S. aureus biofilm formation, we assessed the metabolic requirements of S. aureus growing in a biofilm and …