Medicine and Health Sciences Commons^™

Coronary Heart Disease Knowledge And Risk Factors Among Filipino-Americans Connected To Primary Care Services, Alona N. Dalusung-Angosta

Nursing Faculty Research

Coronary heart disease (CHD) is the leading cause of death of Filipino-Americans (FAs). Despite the growing numbers of FAs in the United States, little is known about their CHD knowledge and risk factors.

The purposes of this study were to examine the baseline knowledge and risk factors of CHD among FAs and to describe the relationships between knowledge, sociodemographic, and socioeconomic characteristic variables of FAs between the ages of 35-75 years.

The study sample consisted of 120 FAs (N = 120) who were connected to primary care services. Data were collected from three primary care clinics in Las Vegas, …

One Toke Over The Line: The Proliferation Of State Medical Marijuana Laws, Troy E. Grandel

The University of New Hampshire Law Review

[Excerpt] “Marijuana has been used for medicinal purposes for at least five thousand years. In fact, it was used medicinally in the United States up until the twentieth century when antidrug zealots managed to prohibit it. Prohibition was the status quo until 1996 when California became the first state to adopt a law allowing medicinal marijuana use. Since then, thirteen additional states, along with the District of Columbia, have enacted similar laws. More states are now lining up with their own laws, which are in various stages of adoption. In addition, the Supreme Court has impacted the issue, both with …

Direct Care Workers Perceptions And Practices Related To Quality Of Life In Long Term Care, Karen M. Kinyon

Dissertations

The focus of this case study was to discover how DCWs define success in their practice and what institutional and individual factors contribute to their successful practices. It describes how DCWs perceive quality of life for NH residents and how their practices reflect quality of life indicators. The conceptual model for which this research is based on was developed around the concepts that individual and institutional factors contribute to the successful practices of direct care workers; and, how these DCWs perceive quality of life influences how they practice to promote quality of life for nursing home residents. Using a case …

Role Of Hypoxia-Inducible Factor-1 Alpha In Neural Stem/Progenitor Cell Function Following Hypoxia, Kate M. Harms Candelario

Biomedical Sciences ETDs

Stroke can be caused by focal ischemia due to cerebral artery occlusion or by global ischemia that occurs when global blood supply to the brain is interrupted. The acute phase of ischemic brain injury is followed by a more prolonged period of revascularization and repair that can last for several months. One hallmark of this repair phase includes an endogenous neural stem/progenitor cell (NSPC) regenerative response that occurs concomitant with angiogenesis. Several studies suggest that the cytogenic response is beneficial for recovery following stroke, however, more studies need to be done to determine whether the beneficial effects are due to …

Mentor Profile, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

C-Jun Inhibits Mammary Apoptosis In Vivo., Sanjay Katiyar, Mathew C Casimiro, Luis Dettin, Xiaoming Ju, Erwin F Wagner, Hirokazu Tanaka, Richard Pestell

Department of Cancer Biology Faculty Papers

c-jun, which is overexpressed in a number of human cancers encodes a critical component of the AP-1 complex. c-jun has been shown to either induce or inhibit cellular apoptosis. Germ line deletion of both c-jun alleles is embryonically lethal. To determine the role of the endogenous c-jun gene in apoptosis, we performed mammary epithelial cell-targeted somatic deletion using floxed c-jun (c-jun(f/f)) conditional knockout mice. Laser capture microdissection demonstrated endogenous c-jun inhibits expression of apoptosis inducing genes and reactive oxygen species (ROS)-reducing genes (MnSOD, catalase). ROS have been implicated in apoptosis and undergo enzymatic elimination via MnSOD and CuZnSOD with further …

Microdiscectomy For Lumbosacral Disc Herniation And Frequency Of Failed Disc Surgery, Muhammad Shahzad Shamim, Maria Adnan Parekh, Muhammad Ehsan Bari, Ather Enam, Faraz Khursheed

Section of Neurosurgery

Background: Microdiscectomy for lumbosacral disc herniations is one of the most commonly performed neurosurgical procedures. The Patient demographics, symptomatology, and recovery are highly variable, and surgical outcomes depend on several factors, including Patient demographics. Failed disc surgery refers to failure of improvement in Patient's symptoms following microdiscectomy, and has been observed to occur in up to 12% of Patients. To date, no study form Pakistan has looked into Patient demographics and failed disc surgery rates within the local context.
Objective:The aim of this study was to review the demographics of the Patient population presenting for surgical treatment of lumbosacral …

Biliary Stones: An Atypical Cause Of Abdominal Pain In Paediatric Age Group, Amber Mehmood, M. Arif Mateen Khan

Department of Emergency Medicine

OBJECTIVE: To identify Paediatric patients with biliary stone disease presenting to a tertiary care hospital in order to determine the etiology, presentation and management.

METHODS: Retrospective study of all cases of ultrasonographically proven biliary stones under the age of 15 years from January 1988 to December 2008. Data included their risk factors, complications, management and outcome.

RESULTS: Total 32 patients were identified with biliary stones, treated in the hospital. Mean age at presentation was 8.25 +/- 3.33 years. Sixteen patients underwent cholecystectomy.

CONCLUSION: Paediatric cholelithiasis is an atypical and under-diagnosed cause of abdominal pain in childhood. True prevalence of the …

Message From The Senior Vice Provost And Dean Of Undergraduate Studies, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Graduate Scholar Profile, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Full Issue, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Accessibility Of Primary Health Care Settings For People With Disabilities, Nancy R. Mudrick, Mary Lou Breslin, Mengke Liang, Silvia Yee

Social Work - All Scholarship

People with disabilities report physical barriers in doctors’ offices that affect the quality of care. The analysis seeks to describe overall primary care office physical accessibility and identify (1) in which areas offices meet access criteria, (2) which accessibility criteria are most often not met, and (3) whether there are urban/non-urban differences.

J Am Coll Dent 2010 77 4

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

Controversies Of Treatment Modalities For Cerebral Venous Thrombosis, Maria Khan, Ayeesha Kamran Kamal, Mohammad Wasay

Department of Medicine

Cerebral vein thrombosis has been well recognized for nearly two centuries. However, therapeutic options for the condition are limited due to lack of large randomized trials. The various modalities reportedly used include antiplatelets, anticoagulation, fibrinolysis, and mechanical thrombectomy. Of these, antiplatelets are the least studied, and there are only anecdotal reports of aspirin use. Anticoagulation is the most widely used and accepted modality with favorable outcomes documented in two randomized controlled trials. Various fibrinolytic agents have also been tried. Local infusions have shown more promise compared to systemic agents. Similarly, mechanical thrombectomy has been used to augment the effects of …

What Are The Current Therapeutic Options For Haemorrhagic Strokes?, Maria Khan, Ayeesha Kamran Kamal

Department of Medicine

No abstract provided.

Homozygous Frame Shift Mutation In Ecm1 Gene In Two Siblings With Lipoid Proteinosis., Azam J. Samdani, Abid Azhar, Syed M. Shahid, Syeda N. . Nawab, Rozeena Shaikh, Shah A. Qader, Qaisar Mansoor, Bahram K. Khoso, Muhammad Ismail

Department of Medicine

Background: The extracellular matrix protein 1 (ECM1) is a glycoprotein, expressed in skin and other tissues. Loss-of-function mutation in ECM1 causes a rare autosomal recessive disorder called lipoid proteinosis. Lipoid proteinosis is presented by varying degrees of skin scars, beaded papules along the eyelid margins, variable signs of hoarseness of voice and respiratory disorders. More than 250 cases of this disorder have been described in the literature, but occurrence of lipoid proteinosis in siblings is very rare. This study was designed to investigate the possible mutation causing lipoid proteinosis in a Pakistani family and to elaborate the scope of possible …

Ocimum Sanctum- A Multicentric Double Blind Homoeopathic Pathogenetic Trial, Rajpal Rajpal, Vinay Singh, R Roy, C Chaudhary, P Mal, A Bhakat

Indian Journal of Research in Homoeopathy

No abstract provided.

Standardization Studies On Cuscuta Reflexa Roxb. - A New Homoeopathic Drug, H Gupta, P Subramanian, P Rao, D Kushwaha, C Nayak

Indian Journal of Research in Homoeopathy

No abstract provided.

Homoeopathic Medicinal Treatment Of Autism, Neeraj Gupta, R Saxena, A Malhotra, Ritu Juneja

Indian Journal of Research in Homoeopathy

No abstract provided.

Effectiveness Of Homoeopathic Medicines In Hiv Patients - A Clinical Trial, K Muraleedharan, S Dey, Popula Prasad, V Siddiqui, Rupali Dixit, Vikram Singh, C Nayak

Indian Journal of Research in Homoeopathy

No abstract provided.

Pemetrexed With Or Without Matuzumab As Second-Line Treatment For Patients With Stage Iiib/Iv Non-Small Cell Lung Cancer, Joan Schiller, Joachim Von Pawel, Philipp Schütt, Rafat Ansari, Michael Bijoy Thomas, Mansoor Saleh, Robert D. Mccroskey, Wolfgang Pfeife, Thomas Marsland, Goetz Kloecker

Haematology and Oncology, East Africa

Introduction: This randomized phase II study investigated pemetrexed in combination with the epidermal growth factor receptor (EGFR)-targeting monoclonal antibody matuzumab compared with pemetrexed alone as second-line therapy for patients with advanced non-small cell lung cancer.

Methods: Patients received pemetrexed 500 mg/m2 every 3 weeks either alone (n = 50) or in combination with matuzumab at either 800 mg weekly (n = 51) or 1600 mg every 3 weeks (n = 47). The primary end point was objective response, as assessed by an independent review committee.

Results: Tumor EGFR expression was detected in 87% of randomized patients. The objective response rate …

Ultrasonographic Diagnosis Of Placenta Accreta, Shaista Afza, Imrana Masroor, Gulnaz Shafqat

Department of Radiology

Placenta accreta is the abnormal adherence of placenta to myometrium due to defect in decidua basalis. This type of placenta could not remove manually after delivery and lead to severe hemorrhage that may result in emergency cesarean hysterectomy. Prenatal diagnosis of placenta accreta is important because it reduces the fetal and maternal morbidity and mortality as appropriate pre-operative and per operative procedures are possible. Grey scale ultrasonography along with color Doppler imaging proves to be the non invasive, real time, readily available modality with high sensitivity and high positive predictive value.

Epicardial Wireless Pacemaker For Improved Left Ventricular Resynchronization (Conceptual Design), Rodney J. Hawkins

Master's Theses

The human body is a well tuned mechanism where systems work in synergy to provide a healthy quality of life. The human circulatory system transports oxygenated blood from the heart to the rest of the body delivering the proper nutrients for cells to function. When the heart malfunctions, serious complications can arise leading to sudden cardiac arrest. Congestive heart failure (CHF) is one heart disease that affects the synchrony of the heart’s ventricles.

Cardiac resynchronization therapy (CRT) has been widely accepted as a treatment for CHF. Similar to traditional dual chamber pacing techniques, CRT adds a pacing lead to stimulate …

Ability Of Clinicians-In-Training To Recognize Vicarious Traumatization: A Multiple Case Study, Amy Cavanaugh

Dissertations

Clinicians repeated exposure to clients who have a history of traumatic experiences can lead to vicarious traumatization (VT), which is the potential for clinicians to experience negative consequences such as changes in their sense of self and worldview (McCann & Pearlman, 1990). Experiencing VT negatively impacts the clinician’s professional identity and counseling work with clients (Pearlman & Saakvitne, 1995a, 1995b; Saakvitne & Pearlman, 1996). Having an awareness of VT is a first step in protecting oneself from experiencing the potential consequences of counseling clients who have experienced trauma. Given this, it seems relevant to understand what clinicians-in-training know about VT. …

Regulation Of Cyclin E Stability In Xenopus Laevis Embryos, Yekaterina Brandt-(Webb)

Biomedical Sciences ETDs

Cyclin-Cdk complexes positively regulate cell cycle progression. Cyclins are regulatory subunits that bind to and activate cyclin-dependent kinases or Cdks. Cyclin E associates with Cdk2 to mediate G1/S phase transition of the cell cycle. Cyclin E is overexpressed in breast, lung, skin, gastrointestinal, cervical, and ovarian cancers. Its overexpression correlates with poor patient prognosis and is involved in the etiology of breast cancer. We have been studying how this protein is downregulated during development in order to determine if these mechanisms are disrupted during tumorigenesis, leading to its overexpression. Using Xenopus laevis embryos as a model, we have shown previously …

An Impaired 20s Proteasome Contributes To The Accumulation Of Oxidized Proteins In Multiple Sclerosis And Its Animal Model, Jianzheng Zheng

Biomedical Sciences ETDs

Carbonylated (oxidized) proteins are known to accumulate in the brain of patients with multiple sclerosis (MS) and in the spinal cord of rats with acute experimental autoimmune encephalomyelitis (EAE). Yet, our knowledge regarding mechanism(s) underlying the build-up of protein carbonyls in these inflammatory demyelinating disorders is quite limited. The objectives of this dissertation were (1) to measure the changes in protein carbonylation during disease progression, and to identify the target cells and modified proteins in the cerebellum of EAE animals, prepared by active immunization of C57/BL6 mice with MOG35-55 peptide, (2) to determine if the accumulation of carbonylated proteins in …

Item Analysis Of The Grammar Subtests Of The Cdi: Words & Sentences For African American Children, Zainab Maqsood

Honors Capstones

No abstract provided.

Pharmacy Newsletter : December 2010, Pharmacy Department

Department of Pharmacy Archives

Content:

• Vancomycin adverse drug reaction
• Recent FDA drug safety updates
• High risk diagnosis
• Top 10 reason for not reporting adverse drug reactions (ADRs)

Development And Validation Of A Rapid Multi-Class Method For The Confirmation Of Fourteen Prohibited Medicinal Additives In Pig And Poultry Compound Feed By Liquid Chromatography Tandem Mass Spectrometry, Mark Cronly, Patrice Behan, Barry Foley, Liam Regan, Marella Gallagher, Sean Earley, Paula Shearan, Edward Malone

Articles

A confirmatory method has been developed to allow for the analysis of fourteen prohibited medicinal additives in pig and poultry compound feed. These compounds are prohibited for use as feed additives although some are still authorised for use in medicated feed. Feed samples are extracted by acetonitrile with addition of sodium sulphate. The extracts undergo a hexane wash to aid with sample purification. The extracts are then evaporated to dryness and reconstituted in initial mobile phase. The samples undergo an ultracentrifugation step prior to injection onto the LC-MS/MS system and are analysed in a run time of 26 minutes. The …

Research To Practice: Vocational Rehabilitation Services Received By Youth With Autism: Are They Associated With An Employment Outcome?, Jaime Lugas, Jaimie Ciulla Timmons, Frank A. Smith

Research to Practice Series, Institute for Community Inclusion

While youth with autism represent a small percentage of all vocational rehabilitation (VR) closures, the number who closed out of VR more than tripled between 2003 and 2008 (see Institute for Community Inclusion Data Note 26). As increasing numbers of youth with autism are accessing VR services, it is important to understand how they are using these services and the relationship of these services to outcomes and costs.