Medicine and Health Sciences Commons^™

R. Jones, Adjutant General’S Office [Washington, Dc] Granting Six-Month Furlough To W. Beaumont. June 6, 1832

1828 - 1832

No abstract provided.

W. B. Lewis, Second Auditor’S Office, Treasury Department [Washington, Dc] To W. Beaumont [Fort Crawford, Prairie Du Chien, Wi] Regarding: Returns Of Medicines And Hospital Stores. July 2, 1832

1828 - 1832

No abstract provided.

Zachary Taylor, First Infantry [Fort Crawford, Wi] Special Orders Regarding W. Beaumont’S Furlough Along With Orders To Take Care Of The Sick And Wounded Militia As Far As Saint Louis. August 22, 1832

1828 - 1832

No abstract provided.

W. Beaumont And St. Martin, Four Articles Of Agreement [Plattsburgh, Ny]. St. Martin To Submit To The Experiments Of Beaumont Under Conditions Fully Set Forth. October 16, 1832–November 7, 1833

1828 - 1832

No abstract provided.

Pill Cochie’S Parting Admonition To His Dear Old Wife, Deborah [Plattsburgh, Ny]. November 1832

1828 - 1832

No abstract provided.

W. Beaumont’S Account Of Money Paid To St. Martin For Experiments. November 1, 1832–October 23, 1833

1828 - 1832

No abstract provided.

Ramsey Crooks To W. Beaumont Regarding: Dinner Invitation. December 17, 1832

1828 - 1832

No abstract provided.

Case Book And Aphorisms Of W. Beaumont, Second Infantry Regarding: Patients Keefe, Ferguson, And Hinkley. December 2, 1826–1830

1828 - 1832

No abstract provided.

W. Beaumont And St. Martin, Draft Articles Of Agreement [Plattsburgh, Ny] Regarding: Planned Experiments. October 1832

1828 - 1832

No abstract provided.

Control Of Catalytic Cycle By A Pair Of Analogous Trna Modification Enzymes., Thomas Christian, Georges Lahoud, Cuiping Liu, Ya-Ming Hou

Department of Biochemistry and Molecular Biology Faculty Papers

Enzymes that use distinct active site structures to perform identical reactions are known as analogous enzymes. The isolation of analogous enzymes suggests the existence of multiple enzyme structural pathways that can catalyze the same chemical reaction. A fundamental question concerning analogous enzymes is whether their distinct active-site structures would confer the same or different kinetic constraints to the chemical reaction, particularly with respect to the control of enzyme turnover. Here, we address this question with the analogous enzymes of bacterial TrmD and its eukaryotic and archaeal counterpart Trm5. TrmD and Trm5 catalyze methyl transfer to synthesize the m1G37 base at …

Teratology Primer-2nd Edition (7/9/2010), Sura Alwan, Steven B. Bleyl, Robert L. Brent, Christina D. Chambers, George P. Daston, Elaine M. Faustman, Richard H. Finnell, F. Clarke Fraser, Jan M. Freidman, Adriane Fugh-Berman, John M. Graham, Jr., Barbara F. Hales, Deborah K. Hansen, Lewis B. Holmes, Ronald D. Hood, Robert J. Kavlock, Thomas B. Knudsen, Joseph Lary, Donald R. Mattison, Richard K. Miller, James L. Mills, Janine E. Polifka, Sonja A. Rasmussen, Bernard Robaire, John M. Rogers, Gary C. Schoenwolf, Anthony R. Scialli, Gary M. Shaw, Amar V. Singh, William Slikker, Jr., Ann P. Streissguth, Melissa S. Tassinari, Janet Uriu-Adams, Charles V. Vorhees, Elora J. Weringer

Department of Pediatrics Faculty Papers

Foreword:

What is Teratology?

“What a piece of work is an embryo!” as Hamlet might have said. “In form and moving how express and admirable! In complexity how infinite!” It starts as a single cell, which by repeated divisions gives rise to many genetically identical cells. These cells receive signals from their surroundings and from one another as to where they are in this ball of cells —front or back, right or left, headwards or tailwards, and what they are destined to become. Each cell commits itself to being one of many types; the cells migrate, combine into tissues, or …

Control Of Catalytic Cycle By A Pair Of Analogous Trna Modification Enzymes., Thomas Christian, Georges Lahoud, Cuiping Liu, Ya-Ming Hou

Department of Biochemistry and Molecular Biology Faculty Papers

Enzymes that use distinct active site structures to perform identical reactions are known as analogous enzymes. The isolation of analogous enzymes suggests the existence of multiple enzyme structural pathways that can catalyze the same chemical reaction. A fundamental question concerning analogous enzymes is whether their distinct active-site structures would confer the same or different kinetic constraints to the chemical reaction, particularly with respect to the control of enzyme turnover. Here, we address this question with the analogous enzymes of bacterial TrmD and its eukaryotic and archaeal counterpart Trm5. TrmD and Trm5 catalyze methyl transfer to synthesize the m1G37 base at …

The Learners' Perspective On Internal Medicine Ward Rounds: A Cross-Sectional Study, M. Tariq, Afaq Motiwala, Syed Umer Ali, Mehmood Riaz, Safia Awan, Jaweed Akhter

Department of Medicine

Background: Ward rounds form an integral part of Internal Medicine teaching. This study aimed to determine the trainees' opinions regarding various aspects of their ward rounds, including how well they cover their learning needs, how they would like the rounds to be conducted, and differences of opinion between medical students and postgraduates. Methods: A cross-sectional study was conducted on a total of 134 trainees in Internal Medicine, comprising medical students, interns, residents and fellows, who were asked to fill in a structured, self-designed questionnaire. Most of the responses required a rating on a scale of 1-5 (1 being highly unsatisfactory …

Diagnostic Utility Of Cerebral White Matter Integrity In Early Alzheimer's Disease, David K. Johnson, Willis Barrow, Raeann E. Anderson, Amith Harsha, Robyn Honea, William M. Brooks, Jeffrey M. Burns

Psychology Faculty Publications

We compared white matter integrity with brain atrophy in healthy controls and participants with very mild dementia (Clinical Dementia Rating 0 vs. 0.5) from the Brain Aging Project, a longitudinal study of aging and memory at the University of Kansas Medical Center. Structural magnetic resonance imaging and diffusion tensor imaging (DTI) including fractional anisotropy and mean diffusivity were performed on 27 patients with very mild dementia (Clinical Dementia Rating = 0.5) of the Alzheimer's type (DAT), and 32 cognitively normal subjects. Patient groups were compared across 6 volumetric measures and 14 DTI regions of interest. Very mildly demented patients showed …

William B. Lewis, Second Auditor’S Office, Treasury Department [Washington, Dc] To W. Beaumont [Saint Louis, Mo] Regarding: Returns Of Hospital And Medical Stores Of September 30, 1837 Received. February 20, 1839

1839

No abstract provided.

Letter From W. B. (William B.) Lewis, Second Auditor’S Office, Treasury Department, Washington, Dc, To W. Beaumont, Saint Louis, Mo, Regarding: Returns Of Hospital And Medical Stores Of September 30, 1837 Received. February 20, 1839

1839

No abstract provided.

A Pilot Study To Determine The Effectiveness Of Probiotic Use In Elderly Patients With Antibiotic-Associated Diarrhea, Jenna L. Peate

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Long-term care settings have the majority of their patients on multiple antibiotics, and outbreaks of antibiotic-associated diarrhea and Clostridium difficile are common. Probiotics have been used with these patients to reduce these side effects. Probiotics can re-establish the composition of intestinal microflora, enhance immune response, and clear pathogens from the host which may reduce the symptoms of antibiotic-associated diarrhea. Therefore, the goal of this study was to conduct a retrospective study of the effectiveness of using probiotic in elderly patients in a long-term care facility in a Midwestern city who suffered from antibiotic-associated diarrhea. The probiotic, CulturelleTM had been administered …

Variability Of Syntactic Complexity In Persons With And Without Multiple Sclerosis, Kristin Diane Bjorkman

Theses and Dissertations

Several recent studies have suggested that persons with multiple sclerosis (MS) have diminished syntactic complexity. A greater variability in responses to a variety of tasks has also been noted for persons with MS. However, naturalistic data on syntactic complexity and the complexity's variability in persons with MS have not been examined. In the present study, 8 volunteers with MS (age 18-70 years) and 10 adults without MS participated in both a 15-minute conversational language sample and a sentence completion task in two different sessions. No significant differences were found between groups on any measure, and variability within the groups was …

2010 July 06 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

The Development Of Attribute Dominance In The Knowledge Base, Marc A. Lindberg Ph.D.

Psychology Faculty Research

Two cuing, free-recall studies were conducted to test Bach and Underwood's (1970) hypothesis that acoustic encoding is dominant among second graders and semantic encoding is dominant among sixth graders. When retrieval cues were presented with to-be-remembered items at both input and output (Experiment 1), and when cues were presented only at output (Experiment 2), semantic cues were more efficient in elevating recall than were acoustic cues for both second and sixth graders. When these and other results generally found using recognition, sorting, incidental learning, and free-recall experimental designs are compared, it seems plausible that item presentation and memory-testing formats interact …

Tapping The Potential Of The Health Care Workforce: Scope-Of-Practice And Payment Policies For Advanced Practice Nurses And Physician Assistants, Robert Cunningham

National Health Policy Forum

Expanding coverage and increasing delivery of team-based care are likely to entail a growing role in the
health system for advanced practice nurses (APNs), physician assistants (PAs), and other nonphysician clinicians. These professions have already grown rapidly and have increased access to primary and specialty care, especially in rural and other underserved areas. This background paper provides an overview of the role of APNs and PAs. It reviews the primary features of the training and credentialing of these health professions, including the impact of public policies and market forces on their growth and deployment. It describes variations in state scope-of-practice …

Pcif1 Modulates Pdx1 Protein Stability And Pancreatic Β Cell Function And Survival In Mice, Kathryn C. Claiborn, Mira M. Sachdeva, Corey E. Cannon, David N. Groff, Jeffrey D. Singer, Doris A. Stoffers

Biology Faculty Publications and Presentations

The homeodomain transcription factor pancreatic duodenal homeobox 1 (Pdx1) is a major mediator of insulin transcription and a key regulator of the β cell phenotype. Heterozygous mutations in PDX1 are associated with the development of diabetes in humans. Understanding how Pdx1 expression levels are controlled is therefore of intense interest in the study and treatment of diabetes. Pdx1 C terminus–interacting factor-1 (Pcif1, also known as SPOP) is a nuclear protein that inhibits Pdx1 transactivation. Here, we show that Pcif1 targets Pdx1 for ubiquitination and proteasomal degradation. Silencing of Pcif1 increased Pdx1 protein levels in cultured mouse β cells, and Pcif1 …

Avirulent Uracil Auxotrophs Based On Disruption Of Orotidine-5′-Monophosphate Decarboxylase Elicit Protective Immunity To Toxoplasma Gondii, Barbara A. Fox, David J. Bzik

Dartmouth Scholarship

The orotidine-5'-monophosphate decarboxylase (OMPDC) gene, encoding the final enzyme of the de novo pyrimidine biosynthesis pathway, was deleted using Toxoplasma gondii KU80 knockouts to develop an avirulent nonreverting pyrimidine auxotroph strain. Additionally, to functionally address the role of the pyrimidine salvage pathway, the uridine phosphorylase (UP) salvage activity was knocked out and a double knockout of UP and OMPDC was also constructed. The nonreverting DeltaOMPDC, DeltaUP, and DeltaOMPDC DeltaUP knockout strains were evaluated for pyrimidine auxotrophy, for attenuation of virulence, and for their ability to elicit potent immunity to reinfection. The DeltaUP knockout strain was replication competent and virulent. In …

Development Of Psychometrically Equivalent Speech Recognition Threshold Materials For Native Speakers Of Samoan, Jennifer Lane Newman

Theses and Dissertations

The speech recognition threshold (SRT) is an important measure, as it validates the pure-tone average (PTA), assists in the diagnosis and prognosis of hearing impairments, and aids in the identification of non-organic hearing impairments. Research has shown that in order for SRT testing to yield valid and reliable measures, testing needs to be performed in the patient's native language. There are currently no published materials for SRT testing in the Samoan language. As a result, audiologists are testing patients with English materials or other materials not of the patient's native language. Results produced from this manner of testing are confounded …

Neural Plasticity And Treatment-Induced Recovery Of Sentence Processing In Agrammatism, Cynthia K. Thompson, Dirk B. Den Ouden, Borna Bonakdarpour, Kyla Garibaldi, Todd B. Parrish

Communication Sciences and Disorders Faculty Articles and Research

This study examined patterns of neural activation associated with treatment-induced improvement of complex sentence production (and comprehension) in six individuals with stroke-induced agrammatic aphasia, taking into account possible alterations in blood flow often associated with stroke, including delayed time-to-peak of the hemodynamic response function (HRF) and hypoperfused tissue. Aphasic participants performed an auditory verification fMRI task, processing object cleft, subject cleft, and simple active sentences, prior to and following a course of Treatment of Underlying Forms (TUF; Thompson et al., 2003), a linguistically based approach for treating aphasic sentence deficits, which targeted object relative clause constructions. The patients also were …

Medical School Watercooler Newsletter - July 4, 2010, Lindsey Lyle

Watercooler Newsletter

This is the July 4, 2010 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Outpatient ENT Practice Added On Campus
• S.T.A.R.S. Program Provides Enrichment Coursework, Health Care Internships for High School Seniors
• Dr. Naritoku Appointed to Serve on Board of American Board of Clinical Pharmacology
• USA Medical Student Returns From Doris Duke Clinical Research Fellowship
• USA College of Medicine Scientist Appointed To Cancer Etiology Study Section

Accuracy Of English Speakers Administering Word Recognition Score Tests In Mandarin, Kaylene Barrett Polley

Theses and Dissertations

The purpose of this study was to examine the accuracy of English-speakers in determining the word recognition score of native Taiwan Mandarin-speakers. Digitally recorded Mandarin word lists were presented to 10 native Mandarin-speakers from Taiwan (five male, five female), from whom oral and written responses were collected. Oral responses were scored by 30 native English-speakers, 15 of which had no experience with Mandarin and 15 with two to three years of college-level Mandarin courses or equivalent knowledge of Mandarin. The judges who had experience with Mandarin were able to score the WRS tests with 97% accuracy (with scores ranging from …

Galactoxylomannans From Cryptococcus Neoformans Varieties Neoformans And Grubii Are Structurally And Antigenically Variable, Magdia De Jesus

Biomedical Sciences Faculty Scholarship

No abstract provided.

In Translation, V.1:No.1 (2010:Summer), Matthew J. Cook

UCHC Articles - Research

Momentum is Strong. Thanks for taking time to learn about some of impressive accomplishments achieved recently by the Connecticut Institute for Clinical and Translational Science (CICATS.) With so much momentum, it’s hard to believe it’s been less than one year since CICATS held its formal launch last fall! True to its mission and goals, CICATS is making great strides to educate and nurture new scientists and increase the number of clinical and translational research projects in the greater Hartford area.

Oral Mucositis: The New Paradigms, Rajesh V. Lalla, Douglas E. Peterson

UCHC Articles - Research

Purpose of review

Mucositis has long been viewed as an unavoidable consequence of high-dose chemotherapy and/or radiation. Management has been directed to supportive care including oral pain control, nutritional support, infection treatment and control of diarrhea. While these interventions have been valuable for clinical management, they have not been collectively directed to molecularly targeted prevention and treatment. This review addresses recent advances regarding mucosal injury in cancer patients, with emphasis on symptom clusters, genetically-based tissue susceptibility and risk prediction, imaging technology, and computational biology.

Recent findings

Modeling of symptom clusters in cancer patients continues to mature. Although integration of mucositis …