Medicine and Health Sciences Commons^™

Early Signals During Cd8+ T Cell Priming Regulate The Generation Of Central Memory Cells, Joshua J. Obar, Leo Lefrancois

UCHC Articles - Research

The CD8⁺ T cell response to infection is characterized by the appearance of short-lived (CD127^low killer cell lectin-like receptor G 1–high) and memory-precursor (CD127^high killer cell lectin-like receptor G 1–low) effector cells. How and when central-memory T (T_CM; CD62L^high CCR7⁺) cell and effector-memory T(T_EM; CD62L^low CCR7⁻) cell subsets are established remains unclear. We now show that the T_CM cell lineage represents an early developmental branchpoint during the CD8⁺ T cell response to infection. Central-memory CD8⁺ T cells could be identified prior to the peak …

Medical Education Digest, Vol. 12 No. 4 (July/August 2010), Nova Southeastern University

Medical Education Digest

No abstract provided.

Mid-Atlantic Ethics Committee Newsletter, Summer 2010

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

Fenotipo Y Genotipo Del Virus De La Diarrea Viral Aislado De Bovinos En El Perú., Mariluz Araínga, Hermelinda Rivera G., Juan Carlos Huaman G., Alberto Manchego S.

Journal Articles: Pharmacology & Experimental Neuroscience

The aim of this study was to determine the phenotype and genotype of Bovine Viral Diarrhoea Virus (BVDV) in Peruvian cattle. During the period 1998-2007, tissues of aborted fetus, blood, serum or plasma samples of bovine with acute infection or persistently infected from dairy herds of various locations in the country were collected and the BVDV antigen was detected by immnunofluorescence or capture ELISA tests, and positive samples were inoculated en BVDV free BT cells and cultured until third passage to determine the biotype. Both animal tissues and third passage of positive samples were tested by a Real Time Reverse …

Use It Or Lose It: Physical Fitness For Nurses, Kelly Amtmann, Msn, Rn, John Amtmann, Edd

Nursing

No abstract provided.

Chhs July Enewsletter, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor, Wku College Of Health & Human Services

College of Health & Human Services Publications

No abstract provided.

The Role Of Gender In Single Vs Married Individuals With Bipolar Disorder., Daniel Z Lieberman, Suena H Massey, Frederick K Goodwin

Psychiatry and Behavioral Sciences Faculty Publications

BACKGROUND: Despite the importance of marriage as a source of social support, it has been largely neglected in studies of bipolar disorder; and differential effects on men and women have not been explored.

METHODS: Data on episodes of depression, mania, and mixed states were collected for the previous 2 years from a sample of 282 bipolar individuals using the National Institute of Mental Health Life Chart Methodology.

RESULTS: Effects unique to women included the following: Bipolar women were significantly more likely to be married. Married women had fewer episodes of depression during the past 2 years than never-married women, and …

Family Functioning And The Development Of Trust And Intimacy Among Adolescents In Residential Treatment, Kenneth M. Coll, Stephanie Powell, Patti Thobro, Robin Haas

Counselor Education Faculty Publications and Presentations

This study examined relations between family cohesion and adaptability (as measured by the Family Adaptability and Cohesion Scales-III) and the formation of trust and intimacy (assessed with the Measure of Psychosocial Development) among adolescents in residential treatment. Bivariate correlation revealed a significant association between family cohesion and adaptability and psychosocial stages of trust and intimacy. Regression analyses revealed that family cohesion predicted trust, and that trust is significantly influential in the formation of intimacy. Discussion and treatment implications are included.

Reducing Heavy Drinking Among First Year Intercollegiate Athletes: A Randomized Controlled Trial Of Web-Based Normative Feedback, Diana M. Doumas, Tonya Haustveit, Kenneth M. Coll

Counselor Education Faculty Publications and Presentations

This study evaluated the efficacy of a web-based personalized normative feedback program targeting heavy drinking in first year intercollegiate athletes. The program was offered through the Athletic Department first year seminar at a NCAA Division I university. Athletes were randomly assigned to either a web-based feedback group or a comparison condition. Results indicated high-risk athletes receiving the intervention reported significantly greater reductions in heavy drinking than those in the comparison group. Additionally, intervention effects were mediated by changes in perceptions of peer drinking. Findings support the use of web-based normative feedback for reducing heavy drinking in first year intercollegiate athletes.

Pediatric Nurses’ Attitudes And Knowledge Regarding The Provision Of Breastfeeding Support In A Pediatric Medical Center, Tracy L. Brewer

Nursing Faculty Publications

Breastfeeding gives all neonates the best nutritional start in life.

The Ethical Balancing Act Of Hospice Care, Paul D. Longenecker

Health and Sport Sciences Faculty Scholarship

In providing hospice care, clinicians are confronted with ethical challenges on a daily basis involving their patients and families, their personal values and beliefs, and organizational practices. Being able to objectively understand these ethical challenges and having a plan of action to address is essential in effectively fulfilling the role of being a hospice professional.

Brain Specificity Of Diffuse Optical Imaging: Improvements From Superficial Signal Regression And Tomography, Nicholas M. Gregg, Brian R. White, Benjamin W. Zeff, Andrew J. Berger, Joseph P. Culver

Open Access Publications

No abstract provided.

Reaching Out To A Global Community, Loma Linda University

Scope

In this issue . . .

2 | Out of the rubble
Loma Linda University works to strengthen Hopital Adventiste d’Haiti

6 | Afghanistan and Loma Linda University
An enduring relationship that spans nearly 50 years

10 | Journey back to health
A physician travels from Germany to Loma Linda for proton therapy

14 | Serving on the home front
Two student outreach programs impact Inland Empire communities

18 | Deferred mission appointment program
Steering young physicians and their families toward mission service

22 | A passion for service
LLU affiliate SACHS–Norton celebrates its 15-year anniversary

26 | Newscope

Assessing Community Health Center (Chc) Assets And Capabilities For Recruiting And Retaining Physicians: The Chc Community Apgar Questionnaire, David Schmitz, Ed Baker, Ayaka Nukui, Benjamin Tverdy

Public and Population Health Faculty Publications and Presentations

Community factors play a key role in the recruitment and retention of physicians. While prior workforce studies often investigated characteristics of the candidate-physician, the initial Critical Access Hospital Community Apgar Questionnaire (CAH CAQ) study identified community factors at critical access hospitals which help determine the success of achieving and maintaining an adequate local physician workforce. The goals of the current study are to identify opportunities for improvement in physician retention and recruitment in Idaho’s Community Health Center (CHC) systems and to develop a better understanding of the community factors in this dynamic process.

Com Outlook Summer 2010, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

The College Of Pharmacy, South Dakota State University

Jackrabbits Script and Scope (Formerly called College of Pharmacy and Allied Health Professions Magazine)

[Page] 2 Avera Health and Science Center Time for construction to yield to classroom work
[Page] 4 Dean’s Club Spotlight Donors Manthei, Casey, Markl, Stai help complete the Avera Center
[Page] 6 Community involvement P3 students engage in health outreach in Sioux Falls
[Page] 7 Patel’s Studies Zambian student says she has found another home in friendly South Dakota
[Page] 8 Spring Convocation Kelly Gellerman - lessons from a cancer survivor
[Page] 9 White Coat Ceremony P1 students cautioned to keep white coats clean [Page] 10 2010 Graduates
[Page] 12 Awards Students receive honors at hooding ceremony
[Page] 13 Distinguished …

A Phenomenological Investigation Of Women's Experiences With Personal Training, Cherilyn N. Hultquist, Melissa N. Madeson, Amy Church, Leslee A. Fisher

Faculty Articles

Personal training is a rapidly growing industry in a country that is in dire need of physical fitness and health improvements. The purpose of this phenomenological study was to better understand women's experiences with personal training. To address the research question, eight female participants ages 24 to 54 years were interviewed using the following phenomenological question: "When you think about your current experience with personal training what stands out for you?" The interviews were conducted, transcribed, and qualitatively analyzed to identify themes in participants' responses. The ground that emerged was positive experience within which existed four figural themes: Relationships, trainer …

Self-Assessed Proficiency And Application Of Various Skills Learned During Postgraduate Pharmacy Teaching Skills Development Programs, Anna Ratka, Paul O. Gubbins, Carol A. Motycka, Jane M. Gervasio, Mark S. Johnson, Ron W. Maddox

Scholarship and Professional Work – COPHS

The purpose of this study was to identify teaching skills commonly taught during the postgraduate pharmacy teaching skills development programs, to describe trainees' perceived teaching proficiency, and the extent to which the learned teaching skills are applied in trainees' current positions. An online survey was developed for pharmacists who completed postgraduate teaching skills development programs. The survey included demographic and program queries as well as questions on 23 teaching skills. Participants self-assessed their proficiency in and application of their learned teaching skills. The online survey resulted in 122 qualified responses. After training, the perceived proficiency in nearly all 23 teaching …

Kcumb Communicator, Summer 2010: Who We Are, Kansas City University Of Medicine And Biosciences

Communicator (1991-2012)

Contents: From the President -- Moving Forward -- The Many Faces of KCUMB -- Making Physical Activity a Community Priority -- Alumni in Politics -- A Nation Apart -- A Family's Journey -- Alumni News -- Campus News -- Faculty and Staff Notes -- Class Notes -- Passages -- Last Look.

Interpretations Of Interpretations: Combining Community-Based Participatory Research And Interpretive Inquiry To Improve Health, Jessica Gregg, Lourdes Centurion, Julio Maldonado, Raquel Aguillon, Rosemary Carmela Celaya-Alston, Stephanie Farquhar

Community Health Faculty Publications and Presentations

Background: Latina immigrants from Mexico suffer significantly increased morbidity and mortality from cervical cancer when compared with non-Hispanic White women, largely owing to lack of screening and appropriate treatment. Objectives: To demonstrate that by combining the tools of community-based participatory research (CBPR) with the tools of interpretive inquiry, it is possible to address explicit community concerns surrounding a particular problem such as cervical cancer while also examining what other, perhaps less immediately visible, matters consume the time and attention of community members. Methods: We first briefly discuss and compare CBPR as an approach to research and interpretive inquiry as a …

Prolongation Of Carrageenan-Induced Inflammation In Human Colonic Epithelial Cells By Activation Of An Nfκb-Bcl10 Loop, Alip Borthakur, Sumit Bhattacharyya, Arivarasu N. Anbazhagan, Anoop Kumar, Pradeep K. Dudeja, Joanne K. Tobacman

Clinical & Translational Sciences

Carrageenan, a sulfated polysaccharide that is widely used as a food additive, induces inflammatory responses in animal models and human cells. The carrageenan-induced inflammatory cascades involve tolllike receptor (TLR)4- and B-cell leukemia/lymphoma (BCL)10-dependent activation of NF-κB, leading to increased IL-8 production. Translocations involving BCL10 in the mucosa-associated lymphoid tissue (MALT) lymphomas are associated with constitutive activation of NF-κB. This report presents a mechanism by which carrageenan exposure leads to prolonged activation of both BCL10 and NF-κB in human colonic epithelial cells. Study findings demonstrate that nuclear RelA and RelB bind to an NF-κB binding motif in the BCL10 promoter in …

Optimal Slice Thickness For Cone-Beam Ct With On-Board Imager., Kyt Seet, A Barghi, Slav Yartsev, Jacob Van Dyk

Oncology Publications

PURPOSE: To find the optimal slice thickness (Δτ) setting for patient registration with kilovoltage cone-beam CT (kVCBCT) on the Varian On Board Imager (OBI) system by investigating the relationship of slice thickness to automatic registration accuracy and contrast-to-noise ratio.

MATERIALS AND METHOD: Automatic registration was performed on kVCBCT studies of the head and pelvis of a RANDO anthropomorphic phantom. Images were reconstructed with 1.0 ≤ Δτ (mm) ≤ 5.0 at 1.0 mm increments. The phantoms were offset by a known amount, and the suggested shifts were compared to the known shifts by calculating the residual error. A uniform cylindrical phantom …

Chronic Obstructive Pulmonary Disease: Longitudinal Hyperpolarized (3)He Mr Imaging, Miranda Kirby, Lindsay Mathew, Andrew Wheatley, Giles E Santyr, David G Mccormack, Grace Parraga

Medical Biophysics Publications

PURPOSE: To quantitatively evaluate a small pilot group of ex-smokers with chronic obstructive pulmonary disease (COPD) and healthy volunteers during approximately 2 years by using hyperpolarized helium 3 ((3)He) magnetic resonance (MR) imaging.

MATERIALS AND METHODS: All subjects provided written informed consent to the study protocol, which was approved by the local research ethics board and Health Canada and was compliant with the Personal Information Protection and Electronic Documents Act and HIPAA. Hyperpolarized (3)He MR imaging, hydrogen 1 MR imaging, spirometry, and plethysmography were performed in 15 ex-smokers with COPD and five healthy volunteers (with the same mean age and …

Deficits In Attention To Emotional Stimuli Distinguish Youth With Severe Mood Dysregulation From Youth With Bipolar Disorder., Brendan A Rich, Melissa A Brotman, Daniel P Dickstein, Derek G V Mitchell, R James R Blair, Ellen Leibenluft

Brain and Mind Institute Researchers' Publications

Studying attention in the context of emotional stimuli may aid in differentiating pediatric bipolar disorder (BD) from severe mood dysregulation (SMD). SMD is characterized by chronic irritability, arousal, and hyper-reactivity; SMD youth frequently receive a BD diagnosis although they do not meet DSM-IV criteria for BD because they lack manic episodes. We compared 57 BD (14.4 +/- 2.9 years old, 56% male), 41 SMD (12.6 +/- 2.6 years old, 66% male), and 33 control subjects (13.7 +/- 2.5 years old, 52% male) using the Emotional Interrupt task, which examines how attention is impacted by positive, negative, or neutral distracters. We …

A Randomized Comparison Of Online And Paper Mood Charts For People With Bipolar Disorder., Daniel Z Lieberman, Tammas F Kelly, Lanny Douglas, Frederick K Goodwin

Psychiatry and Behavioral Sciences Faculty Publications

BACKGROUND: Longitudinal mood instability is the essential feature of bipolar disorder, however most rating scales are cross sectional in nature, and focus on acute symptoms. By contrast, the NIMH Life Chart Methodology (LCM) characterizes in detail the severity, duration, and frequency of mood episodes. Adherence to daily rating, however, tends to be low. In this study an online version of the LCM, designed to enhance adherence, was compared to the standard paper version.

METHODS: Patients from a mood disorders specialty clinic were randomized to the standard LCM or an online, open-source adaptation. The online version used hypertext links embedded in …

What's Happening: July, 2010, Maine Medical Center

What's Happening

No abstract provided.

Peripheral Arterial Disease In Hiv Positive And Negative Subjects At The Aga Khan University Hospital, Nairobi, Farida Kaittany

Master of Medicine in Internal Medicine

Aim: To determine the prevalence of peripheral arterial disease (PAD) amongst HIV positive patients and HIV negative subjects and associated risk factors at Aga Khan Hospital Nairobi Design: Cross-sectional descriptive study Patients and Setting: A group of 125 HIV positive and 120 HIV negative subjects aged between 40 – 70 years were included in the study. HIV negative subjects were sampled from HIV positive patients attending the HIV outpatient clinic while HIV negative subjects were sampled from blood donor unit at theAga KhanUniversityHospital. Methodology: Two separate convenient samples were selected for the study. The first sample was a group of …

Cardinal Athletics Summer 2010, Otterbein University

Cardinal Athletics Newsletter

No abstract provided.

Detection Of Extended Spectrum Beta Lactamases Genotypes And Their Association With Cephalosporin Susceptibility In Community Acquired Enterobacteriaceae Infections, Daniel W. Maina

Master of Medicine in Clinical Pathology

Background: Infections caused by Extended Spectrum Beta-Lactamases (ESBLs) producing enterobacteriaceae have become a global problem. Initially confined to the hospital set-up, they are increasingly being reported in the community. These infections are often resistant to a wide variety of B- lactams including extended spectrum cephalosporins, with clinical and epidemiological implications for healthcare systems and necessitate surveillance measures based on local data. Local information on the genotypes of ESBLs and their association with cephalosporin resistance in community acquired ESBL-producing Enterobacteriaceae isolates is scanty, hence the need for this study. Aim: To detect ESBLs genotypes and correlate these with susceptibility to cephalosporins …

Jefferson Review - Summer 2010

Jefferson Review

Content

Features

• 4 - Prospects Promising for Jefferson Grads Despite Struggling Economy
• 8 - Haiti's Earthquake: Jefferson Alumni Respond
• 12 - Sensory Integration and Autism: Putting the Pieces Together

On Campus

• 14 - School of Health Professions
• 17 - School of Nursing
• 18 - School of Pharmacy
• 18 - School of Population Health
• 21 - Class Notes