Medicine and Health Sciences Commons^™

Psychometric Properties Of Three Instruments To Measure Fatigue With Myocardial Infarction, Ann Eckhardt, Anne Fink, Michelle Fennessy, Jessica Jones, Donna Kruse, Kathryn Vanderzwan, Catherine Ryan, Julie Zerwic

Scholarship

The purpose of this study was to evaluate the psychometric properties of three questionnaires to measure fatigue with myocardial infarction. The Fatigue Symptom Inventory Interference Scale, Profile of Moods States Fatigue subscale (POMS-F), and Short Form 36 (SF-36) Vitality Scale were completed during hospitalization (n = 116) and 30 days after hospital admission (n = 49). Moderate to strong correlations were found among each of these fatigue scales and between each fatigue scale and measures of other variables to include vigor, depressed mood, anxiety, and physical functioning. POMS-F scores decreased significantly at Time 2, but this decline in …

Cord Blood Versus Age 5 Mononuclear Cell Proliferation On Ige And Asthma, Carolyn Chang, Kevin Gauvey-Kern, Alina Johnson, Elizabeth A. Kelvin, Ginger L. Chew, Frederica Perera, Rachel L. Miller

Publications and Research

Background: Fetal immune responses following exposure of mothers to allergens during pregnancy may influence the subsequent risk of childhood asthma. However, the association of allergen-induced cord blood mononuclear cell (CBMC) proliferation and cytokine production with later allergic immune responses and asthma has been controversial. Our objective was to compare indoor allergen-induced CBMC with age 5 peripheral blood mononuclear cell (PBMC) proliferation and determine which may be associated with age 5 allergic immune responses and asthma in an inner city cohort.

Methods: As part of an ongoing cohort study of the Columbia Center for Children’s Environmental Health (CCCEH), CBMCs and age …

Diaphragm Weakness And Mechanical Ventilation – What's The Critical Issue?, Leigh Ann Callahan, Gerald S. Supinski

Internal Medicine Faculty Publications

While animal studies indicate that controlled mechanical ventilation (MV) induces diaphragm weakness and myofiber atrophy, there are no data in humans that confirm MV per se produces diaphragm weakness. Whether or not diaphragm weakness results from MV, sepsis, corticosteroids, hyperglycemia, or a combination of these factors, however, is not the most important issue raised by the recent study from Hermans and colleagues. This study makes an important contribution by providing additional evidence that many critically ill patients have profound diaphragm weakness. If diaphragm weakness of this magnitude is present in most mechanically ventilated patients, a strong argument can be made …

Mononucleosis And Antigen-Driven T Cell Responses Have Different Requirements For Interleukin-2 Signaling In Murine Gammaherpesvirus Infection, Michael Molloy, Weijun Zhang, Edward Usherwood

Dartmouth Scholarship

Interleukin-2 (IL-2) has been implicated as being necessary for the optimal formation of primary CD8⁺ T cell responses against various pathogens. Here we have examined the role that IL-2 signaling plays in several aspects of a CD8⁺ T cell response against murine gammaherpesvirus 68 (MHV-68). Exposure to MHV-68 causes a persistent infection, along with infectious mononucleosis, providing a model for studying these processes in mice. Our study indicates that CD25 is necessary for optimal expansion of the antigen-specific CD8⁺ T cell response but not for the long-term memory response. Contrastingly, IL-2 signaling through CD25 is absolutely required …

Environmental Responses Of Two-Component Systems In Streptococcus Sanguinis, Jenishkumar Patel

Theses and Dissertations

The gram-positive bacterium Streptococcus sanguinis is a member of human indigenous oral microbialflora and has long been recognized as a key player in the bacterial colonization of the mouth. S. sanguinis is also the most common viridians streptococcal species implicated in infective endocarditis. Although many studies have focused on two-component systems in closely related Streptococcus species such as S. mutans, S. pneumoniae and S. gordonii; the mechanism of the response regulator in S. sanguinis is still unknown. The ability of S. sanguinis to adapt and thrive in hostile environments suggests this bacterium is capable of sensing and responding to various …

Y-Aminobutyric Acid Inhibits Synergistic Interleukin-6 Release And Increases Intracellular Cytokine Content In C6 Astrocytoma Cells In Vitro, Daniella Sandoval, Becky M. Hess, Bryan L. Spangelo

Undergraduate Research Opportunities Program (UROP)

Alzheimer’s disease (AD) is a neurodegenerative disorder that is characterized by memory loss and is the most common cause of dementia. It is has been hypothesized that pro-inflammatory cytokines induce the inflammation that is believed to be the cause of the neuronal death that is associated with AD. γ-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the Central Nervous System possessing membrane hyperpolarization or depolarization activities. A decline in GABA may enhance cytokine release in Alzheimer’s disease resulting in neuroinflammation. Therefore, we investigated the GABA-mediated suppression of the synergistic release of interleukin-6 (IL-6) induced by interleukin 1- (IL-1) and …

Construction And Use Of A Calorimeter To Estimate The Anaerobic Contributions To Metabolism, Mark S. Burger, Frank Van Breukelen

Undergraduate Research Opportunities Program (UROP)

Metabolism is derived from the Greek word metabole which translates to change. Metabolism is the sum total of chemical reactions that take place in an organism. Some reactions are exothermic (heat-producing) whereas others are endothermic (heat-absorbing). By measuring heat production (calorimetry), one can estimate metabolic rate. Historically, such measurements of direct calorimetry were difficult. As a result, most studies utilize indirect calorimetry wherein oxygen consumption and/or carbon dioxide production are measured. One limitation to this approach is that anaerobic metabolism is ignored. No commercially-available calorimeter is available for whole animal metabolic studies. We hypothesized that small rodent hibernators may experience …

Synthesis Of Novel Aromatic Quinols For Colon And Renal Cancers, Bradley J. Davey, Tae Soo Jo, Pradip K. Bhowmik

Undergraduate Research Opportunities Program (UROP)

Colon Cancer: The third most common cancer in USA. More than 1 million Americans currently living with colon cancer. 148,810 new cases expected in 2010. 50,000 deaths annually.

Renal Cancer: Approximately 58,000 people diagnosed in USA annually. Seventh most common cancer and tenth most common cause of cancer related death in men.

Aromatic quinols have demonstrated in vitro antitumor activity. Three heteroaromatic quinols show antitumor activity.

Undergraduate Research Opportunities Program 2010, University Of Nevada, Las Vegas

Undergraduate Research Opportunities Program (UROP)

The Undergraduate Research Opportunities Program (UROP) cultivates and supports research partnerships and invites undergraduates to work as the junior colleagues of faculty. The program offers the opportunity to work on cutting edge research—whether you join established research projects or pursue your own ideas. As participants, undergraduates engage in each phase of standard research activity: developing research plans, writing proposals, conducting research, analyzing data. and presenting research results in oral and written form. The projects take place over the summer, and research can be done in any academic department or interdisciplinary laboratory. Projects can last for an entire semester, and many …

2010 August 03 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Foreign-Born Semi Driver Dies After Driving Over Embankment, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

One summer morning in 2009, at approximately 11:30 AM, a 41 year-old male, long-haul, semi tractor-trailer driver drove off an interstate highway, over a guardrail, and continued into a wooded ravine. His trailer was empty and he was travelling to pick up a load of retail goods. The trailer disengaged from the tractor, the fuel tanks ruptured, the tractor overturned and caught fire. As the tractor overturned, the driver was ejected. A passing motorist called emergency medical (EMS) services; EMS arrived and found the driver dead at the scene.

To prevent future occurrences of similar incidents, the following recommendations have …

Cross-Reactivity Of Antibodies Against Leptospiral Recurrent Uveitis-Associated Proteins A And B (Lrua And Lrub) With Eye Proteins, Ashutosh Verma, Pawan Kumar, Kelly Babb, John F. Timoney, Brian Stevenson

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Infection by Leptospira interrogans has been causally associated with human and equine uveitis. Studies in our laboratories have demonstrated that leptospiral lipoprotein LruA and LruB are expressed in the eyes of uveitic horses, and that antibodies directed against LruA and LruB react with equine lenticular and retinal extracts, respectively. These reactivities were investigated further by performing immunofluorescent assays on lenticular and retinal tissue sections. Incubation of lens tissue sections with LruA-antiserum and retinal sections with LruB-antiserum resulted in positive fluorescence. By employing two-dimensional gel analyses followed by immunoblotting and mass spectrometry, lens proteins cross-reacting with LruA antiserum were identified to …

Volumetric Growth Model Of Human Medulloblastoma In The Nude Mouse Cerebellum, Thomas Gavigan

Theses and Dissertations

Medulloblastoma is the most common brain tumor in children, accounting for 10-20% of primary central nervous system (CNS) neoplasms and approximately 40% of all posterior fossa tumors. It is a highly invasive embryonal neuroepithelial tumor that typically arises in the cerebellar vermis and has a tendency to disseminate throughout the CNS early in its course. The molecular mechanisms of the disease largely remain uncharacterized, as the clinical treatment is still associated with mortality and severe side effects. The development of a clinically relevant in vivo model is important not only to further understand the disease but also to provide a …

Ada News - 08/02/2010, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

When Athletes Become Legends, Do Their Sponsors Also, Rick Burton, Norm O'Relly

Sport Management - All Scholarship

No abstract provided.

A Coupled Finite Element-Boundary Element Method For Modeling Diffusion Equation In 3d Multi-Modality Optical Imaging, Subhadra Srinivasan, Hamid R. Ghadyani, Brian W. Pogue, Keith D. Paulsen

Dartmouth Scholarship

Three dimensional image reconstruction for multi-modality optical spectroscopy systems needs computationally efficient forward solvers with minimum meshing complexity, while allowing the flexibility to apply spatial constraints. Existing models based on the finite element method (FEM) require full 3D volume meshing to incorporate constraints related to anatomical structure via techniques such as regularization. Alternate approaches such as the boundary element method (BEM) require only surface discretization but assume homogeneous or piece-wise constant domains that can be limiting. Here, a coupled finite element-boundary element method (coupled FE-BEM) approach is demonstrated for modeling light diffusion in 3D, which uses surfaces to model exterior …

Factors Affecting Gingival Excess, Altered Passive Eruption And Recession In The Mandibular Anterior And Premolar Sites, William Bohlen

Theses and Dissertations

Abstract FACTORS AFFECTING GINGIVAL EXCESS, ALTERED PASSIVE ERUPTION AND RECESSION IN THE MANDIBULAR ANTERIOR AND PREMOLAR SITES By William F Bohlen, D.M.D. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Dentistry at Virginia Commonwealth University. Virginia Commonwealth University, 2010 Major Director: Thomas Waldrop, DDS, MS Program director, Department of Periodontics, Virginia Commonwealth University AIM: The aim of this study was to determine the factors affecting gingival excess, altered passive eruption and recession. METHODS: 100 subjects were examined clinically and models of their mandible were fabricated. Demographic, periodontal and cast measurements were …

Klf2/Klf4 Double Knock-Out Mouse Embryos Show Cranial Bleeding With Endothelial Disruption Of The Primary Head Vein, Benjamin Curtis

Theses and Dissertations

Krüppel-like factors (KLFs) are a family of 3 Cys2/His2 zinc finger transcription factors with a diverse set of roles in cellular differentiation, cell cycle regulation, tumor suppression, erythropoiesis, angiogenesis, and other processes. During embryonic development, KLF2 has a role in vessel maturation. Adult conditional KLF4 knockout mouse embryos have thickened arterial intima follow vascular injury. Breeding KLF2+/- and KLF4+/- mice resulted in the generation of KLF2/KLF4 double knockout (DKO) embryos. KLF2/KLF4 DKO embryos died by E10.5 with cranial bleeding. Using immunohistochemistry, embryo whole-mounts were examined for differences in gross vascularization between wild-type (WT), KLF2-/- and KLF2/KLF4 (DKO embryonic day 9.5 …

Novel Roles For Reelin In Retinogeniculate Targeting, Cheryl Haner

Theses and Dissertations

In the developing visual system, the axon of a pre-synaptic cell must be guided to a post-synaptic partner. Retinal ganglion cells (RGCs) in the eye are an excellent model to study this process. Multiple classes exist that respond to specific types of light input, and these project to different destinations in the brain that process distinct types of information. The RGC axons that navigate to the lateral geniculate nucleus (LGN) do so in a class-specific manner. Axons from RGCs that mediate non-image forming functions innervate the ventral LGN (vLGN) and the intergeniculate leaflet (IGL). Axons from RGCs that process image-forming …

An Analysis Of Electronically Monitored Adherence To Antiretroviral Medications, Kevin D. Dieckhaus

Articles - Patient Care

Medication adherence studies increasingly collect data electronically, often using Medication Event Monitoring System (MEMS) caps. Analyses typically focus on summary adherence measures, although more complete analyses are possible using adaptive statistical methods. These methods were used to describe individual-subject adherence patterns for MEMS data from a clinical trial. Subjects were adaptively clustered into groups with similar adherence patterns and clusters were compared on a variety of subject characteristics. There were seven different adherence clusters: consistently high, consistently moderately high, consistently moderate, consistently moderately low, consistently low, deteriorating starting early, and deteriorating late. Compared to other subjects, subjects with consistently high …

Polymorphisms In The Macrophage Migration Inhibitory Factor Gene And Bone Loss In Postmenopausal Women, George A. Kuchel, Anne M. Kenny

UCHC Articles - Research

Osteoporosis is a severe condition in postmenopausal women and a common cause of fracture. Osteoporosis is a complex disease with a strong genetic impact, but susceptibility is determined by many genes with modest effects and environmental factors. Only a handful of genes consistently associated with osteoporosis have been identified so far. Inflammation affects bone metabolism by interfering with the interplay between bone resorption and formation, and many inflammatory mediators are involved in natural bone remodeling. The cytokine macrophage migration inhibitory factor (MIF) has been shown to affect bone density in rodents, and polymorphisms in the human MIF promoter are associated …

Teacher Attunement To Kestenberg Movement Profile Tension Flow Attributes In Preschool Transition Planning, Anna Carolyn O'Connell

Creative Arts Therapies Theses

Using the action research methodology, the purpose of my project was to develop transition tools based on the Kestenberg Movement Profile (KMP) tension flow attributes (TFA) that could improve the working relationship between preschool children and their teachers during specific transition times in their daily routine. The data collection, via videotape, written observation, discussions with the teachers, and the data analysis was an ongoing process from the beginning of the study until each plan had been put into practice for a few weeks. I analyzed each of the videotapes, my written observations, and the ideas discussed in meetings with the …

The Space Between Us: The Experience Of Relationship In The Argentine Tango, Greta Polo

Creative Arts Therapies Theses

The purpose of this thesis project was to gain an in-depth understanding of the various dimensions of relationship experienced by Argentine tango dancers. The project’s underlying aim was to serve as a springboard for developing future applications of relationally oriented tango work for singles, couples, and groups as a form of dance/movement therapy. The participants consisted of three male tango “leaders” and three female “followers” of various experience levels. The research was conducted by video recording the participants dancing tango with one another and then interviewing them separately, using a customized video for each as a prompt to foster discussion …

A Dance/Movement Therapist's Experience Of Vicarious Trauma And Burn-Out: An Autoethnography, Elliotte Munnell Trif

Creative Arts Therapies Theses

This thesis is an autoethnography investigating how the dance/movement therapist can experience and recover from vicarious trauma and burn-out. The purpose of this research is to provide an example of how theories from the latest research have played out in real life and to call for further research and education on the topic in the dance/movement therapy (DMT) field. The author outlines in narrative form significant moments from her master’s internship work with a traumatized child to demonstrate this phenomenon. What is found is that two core components of DMT, somatic attunement and empathy, contribute to the acquisition of vicarious …

Finding My Feet: A Dance/Movement Therapy Intern's Heuristic Inquiry Of Clinician Self-Care, Megan J. Blazek

Creative Arts Therapies Theses

This study is a heuristic exploration of the internship experience of one dance/movement therapy intern and the search for effective self-care methods to assist in maintaining a sense of calm and stability, as well as a sense of focus during the final academic year of a dance/movement therapy master’s program. Themes of personal and emotional stressors such as premenstrual dysphoric disorder, balancing personal and a newly emerging professional life, fitting personal religion into a secular field, trying to find self-confidence in a new creative and therapeutic role, and determining how much self-care is too much are all discussed. Previous research …

Medical School Watercooler Newsletter - August 1, 2010, Lindsey Lyle

Watercooler Newsletter

This is the August 1, 2010 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

• August Med School Café - "Autism Services in South Alabama"
• Dr. Jane Reusch Speaks at 37th Annual Medical Student Research Day
• USA Surgical Research Fellow Wins Paper Competition at 2010 ACS Meeting
• "Room with a View" Photography Exhibit at USA Library Features Mike Carmichael
• Bioimaging Core Facility Installs Nikon A-1 Spectral Confocal Microscope

Improving Caloric Intake And Nutrition For Elderly Dementia Patients By Modifying The Environment, Tiffany Hobbs, Sheila Hutchens

Graduate Research Projects

Visual perception, difficulty distinguishing objects, judging distance and determining color or contrast are common problems contributing to weight loss and nutritional decline in dementia clients. Mealtime burdens and challenges for individuals with dementia can be minimized or eliminated by some simple, inexpensive alterations in the physical environment that can profoundly influence how patients feel, behave, and function; as well as ease frustration and promote more independent functioning. The purpose of this pilot study was to examine the effect of table setting contrast on residents’ weight, oral intake, arm circumference, and feeding behaviors during meals in an assisted living facility serving …

Bmpa Is A Surface-Exposed Outer-Membrane Protein Of Borrelia Burgdorferi, Anton V. Bryksin, Alexandra Tomova, Henry P. Godfrey, Felipe C. Cabello

NYMC Faculty Publications

BmpA is an immunodominant protein of Borrelia burgdorferi as well as an arthritogenic factor. Rabbit antirecombinant BmpA (rBmpA) antibodies were raised, characterized by assaying their cross reactivity with rBmpB, rBmpC and rBmpD, and then rendered monospecific by absorption with rBmpB. This monospecific reagent reacted only with rBmpA in dot immunobinding and detected a single 39 kDa, pI 5.0, spot on two-dimensional immunoblots. It was used to assess the BmpA cellular location. BmpA was present in both detergent-soluble and -insoluble fractions of Triton X-114 phase-partitioned borrelial cells, suggesting that it was a membrane lipoprotein. Immunoblots of proteinase K-treated intact and Triton …

The Effect Of Proprioceptive Neuromuscular Facilitation Stretching On Flexibility, Muscle Power, And Aerobic Fitness, Dustin Rex

Graduate Theses

Proprioceptive neuromuscular facilitation (PNF) is a commonly used stretching technique in rehabilitation and athletic competition. The most accepted benefit associated with PNF has been for increasing flexibility; however its definitive effect on muscle power and aerobic fitness remains controversial and relatively unknown. The purpose of this study was to determine the effect of prolonged use of PNF on flexibility at the hip, muscle power of the hamstring and aerobic capacity measured during submaximal exercise. Testing this required the participation of 10 adults split into two groups, who were tested for flexibility, muscle power, and aerobic capacity at three levels based …

Chhs August Enewsletter, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor, Wku College Of Health & Human Services

College of Health & Human Services Publications

No abstract provided.