Medicine and Health Sciences Commons^™

Gram-Negative Bacteraemia In Non-Icu Patients: Factors Associated With Inadequate Antibiotic Therapy And Impact On Outcomes, Jonas Marschall, Denis Agniel, Victoria J. Fraser, Joshua Doherty, David K. Warren

ICTS Faculty Publications

No abstract provided.

Eye Malformations In Children With Heavy Alcohol Exposure In Utero, Elizabeth Y. Flanigan, Sora Aros, Maria Ferraz Bueno, Mary Conley, James F. Troendle, Fernando Cassorla, James L. Mills

Uniformed Services University of the Health Sciences

Objective: To determine whether children who do not develop fetal alcohol syndrome (FAS) despite heavy alcohol exposure are at risk for eye abnormalities.
Study design: We screened 9628 pregnant women and identified 101 women who were drinking > 2 oz of absolute alcohol per day and 101 nondrinking control women. We followed 43 exposed and 55 control offspring between age 4 and 9 years, performing masked standardized ophthalomologic examinations.
Results: The groups did not differ in their rates of impaired visual acuity, refractory errors, ptosis, epicanthal folds, or short palpebral fissures. Biomicroscopy examination was normal in all exposed …

Duffy Antigen Receptor For Chemokines Mediates Trans-Infection Of Hiv-1 From Red Blood Cells To Target Cells And Affects Hiv-Aids Susceptibility, Weijing He, Stuart Neil, Hemant Kulkarni, Edward Wright, Brian K. Agan, Vincent C. Marconi, Matthew J. Dolan, Robin A. Weiss, Sunil K. Ahuja

Uniformed Services University of the Health Sciences

Duffy antigen receptor for chemokines (DARC) expressed on red blood cells (RBCs) influences plasma levels of HIV-1-suppressive and proinflammatory chemokines such as CCL5/RANTES. DARC is also the RBC receptor for Plasmodium vivax. Africans with DARC -46C/C genotype, which confers a DARC negative phenotype, are resistant to vivax malaria. Here, we show that HIV-1 attaches to RBCs via DARC, effecting trans-infection of target cells. In African Americans, DARC -46C/C is associated with 40% increase in the odds of acquiring HIV-1. If extrapolated to Africans, ~11% of the HIV-1 burden in Africa may be linked to this genotype. …

Predicting, Preparing For, And Creating The Future: What Will Happen To Internal Medicine?, Paul A. Hemmer, Sheila T. Costa, Deborah M. Demarco, Stuart L. Linas, Don C. Glazier, Barbara L. Schuster

Uniformed Services University of the Health Sciences

It is the year 2025. During the past 20 years, internal medicine as a discipline continued to become less prestigious, less respected, and more fragmented. As fewer medical students chose internal medicine as a career, residency programs began to close. Those that remained open filled with fewer graduates of US medical schools but filled with more US citizens who graduated from international medical schools, more graduates of osteopathic medical schools, and more foreign graduates of international medical schools. Due to lack of adequate remuneration and a shift of primary care provision from generalist physicians to nurse practitioners and physician assistants, …

Psychometric Properties Of A New Questionnaire To Assess Eating In The Absence Of Hunger In Children And Adolescents, Marian Tanofsky-Kraff, Lisa M. Ranzenhofer, Susaz Z. Yanovski, Natasha A. Schvey, Myles Faith, Jennifer Gustafson, Jack A. Yanovski

Uniformed Services University of the Health Sciences

Background: Eating in the absence of hunger (EAH), studied in the context of laboratory paradigms, has been associated with obesity and is predictive of excess weight gain in children. However, no easily administered questionnaire exists to assess for EAH in children.
Objective: We developed an Eating in the Absence of Hunger Questionnaire to be administered to children and adolescents (EAH-C) and examined psychometric properties of the measure.
Design: Two-hundred and twenty-six obese (BMI ≥ 95th percentile for age and sex, n = 73) and non-obese (BMI < 95th percentile, n = 153) youth (mean age ± S.D., 14.4 ± 2.5 y) completed the …

Houston History Of Medicine Society 2008-2009 Schedule And Abstracts, Houston History Of Medicine Society

Houston History of Medicine Lectures (2006-2012)

• The National Library of Medicine and the Continuing Legacy of Michael E. DeBakey, M.D. (Stephen B. Greenberg)
• The Legacy of William Osler: North America’s most famous physician (Robert E. Rakel)
• A Lady Alone: Elizabeth Blackwell: First American Woman Doctor (Linda Gray Kelley, Charlton)
• A Mariner with Crippling Arthritis and Bleeding Eyes: The Chronic Arthritis of Christopher Columbus (Frank C. Arnett)
• Generation C(affeine): A History of Caffeine Consumption and its Medical Implications (Student Essay Contest winners) (Priti Dangayach)
• Our Artificial Fitness? Relaxed Selection Leads to Medical Dependence (Student Essay Contest winners) Philip Boone
• Remembering John P. McGovern, M.D. (1921-2007) (Bryant Boutwell) …

Department Of Education: Fy2008 Annual Report, Lehigh Valley Health Network

Department of Education

No abstract provided.

State Agency Promising Practice: Washington - Collaborating With A Community College And A Supported-Employment Agency To Facilitate The Transition From High School To Community Employment, Jean Winsor, Thinkwork! At The Institute For Community Inclusion At Umass Boston

ThinkWork! Publications

Beginning in 2006, the Shoreline Public School District in King County, Washington partnered with Shoreline Community College to offer an off-campus transition program for young adults with intellectual disabilities and developmental disabilities (ID/DD) residing in the Shoreline School District. While participants are still in high school, the Community Based Transition Program offers a structured transitional step between their traditional day and post-secondary education as well as employment in the community. Funding for the classroom space on the college campus, the special education teacher and the education support staff are all provided by the school district. The school also proposed that …

State Agency Promising Practice: Wisconsin’S Job Development Mentors Project, Jaimie Ciulla Timmons, Thinkwork! At The Institute For Community Inclusion At Umass Boston

ThinkWork! Publications

Sponsored by Wisconsin’s Department of Health and Family Services (DHFS) through the use of Medicaid Infrastructure Grant (MIG) funds, Wisconsin’s Job Development Mentors Project (JDMP) pairs three seasoned job developers with four community-based employment support providers that cover 12 counties throughout the state. JDMP is designed to create a state-wide infrastructure for professionals who are responsible for developing jobs for individuals in supported employment while at the same time, working towards increasing the pool of well-trained job developers around the state of Wisconsin.

Sensitization Of Ovarian Cancer Cells To Cisplatin By Genistein: The Role Of Nf-Kappab, Leigh A. Solomon, Shadan Ali, Sanjeev Banerjee, Adnan R. Munkarah, Robert T. Morris, Fazlul H. Sarkar

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Platinum-resistance (PR) continues to be a major problem in the management of epithelial ovarian cancer (EOC). Response to various chemotherapeutic agents is poor in patients deemed PR. Genistein, a soy isoflavone has been shown to enhance the effect of chemotherapy in prostate and pancreatic cancer cells in vitro and in vivo by reversing chemo-resistance phenotype. The goal of this study was to investigate the effects of combination therapy with genistein and cisplatin as well as other cytotoxic conventional chemotherapeutic agents in platinum-sensitive (PS) and resistant EOC cells.

Methods

The PS human ovarian cancer cell line A2780 and its …

Droid: The Drosophila Interactions Database, A Comprehensive Resource For Annotated Gene And Protein Interactions, Jingkai Yu, Svetlana Pacifico, Guozhen Liu, Russell L. Finley Jr

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Charting the interactions among genes and among their protein products is essential for understanding biological systems. A flood of interaction data is emerging from high throughput technologies, computational approaches, and literature mining methods. Quick and efficient access to this data has become a critical issue for biologists. Several excellent multi-organism databases for gene and protein interactions are available, yet most of these have understandable difficulty maintaining comprehensive information for any one organism. No single database, for example, includes all available interactions, integrated gene expression data, and comprehensive and searchable gene information for the important model organism, Drosophila melanogaster. …

A Stable Explant Culture Of Her2/Neu Invasive Carcinoma Supported By Alpha-Smooth Muscle Actin Expressing Stromal Cells To Evaluate Therapeutic Agents, Marie P. Piechocki

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

To gain a better understanding of the effects of therapeutic agents on the tumor microenvironment in invasive cancers, we developed a co-culture model from an invasive lobular carcinoma. Tumor cells expressing HER2/neu organize in nests surrounded by alpha-Smooth Muscle Actin (α-SMA) expressing tumor stroma to resemble the morphology of an invading tumor. This co-culture, Mammary Adenocarcinoma Model (MAM-1) maintains a 1:1 ratio of HER2/neu positive tumor cells to α-SMA-reactive stromal cells and renews this configuration for over 20 passages in vitro.

Methods

We characterized the cellular elements of the MAM-1 model by microarray analysis, and immunocytochemistry. We developed …

Detailed Characterization Of The Mouse Embryonic Stem Cell Transcriptome Reveals Novel Genes And Intergenic Splicing Associated With Pluripotency, Galih Kunarso, Kee-Yew Wong, Lawrence W. Stanton, Leonard Lipovich

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Transcriptional control of embryonic stem (ES) cell pluripotency has been a subject of intense study. Transcriptional regulators including Oct4 (Oct3/4 index), Sox2 and Nanog are fundamental for maintaining the undifferentiated state. However, the ES cell transcriptome is not limited to their targets, and exhibits considerable complexity when assayed with microarray, MPSS, cDNA/EST sequencing, and SAGE technologies. To identify novel genes associated with pluripotency, we globally searched for ES transcripts not corresponding to known genes, validated their sequences, determined their expression profiles, and employed RNAi to test their function.

Results

Gene Identification Signature (GIS) analysis, a SAGE derivative distinguished …

N-Hexanoyl Chitosan Stabilized Magnetic Nanoparticles: Implication For Cellular Labeling And Magnetic Resonance Imaging, Shanta R. Bhattarai, Remant B. Kc, Sun Y. Kim, Manju Sharma, Myung S. Khil, Pyoung H. Hwang, Gyung H. Chung, Hak Y. Kim

Wayne State University Associated BioMed Central Scholarship

Abstract

This project involved the synthesis of N-hexanoyl chitosan or simply modified chitosan (MC) stabilized iron oxide nanoparticles (MC-IOPs) and the biological evaluation of MC-IOPs. IOPs containing MC were prepared using conventional methods, and the extent of cell uptake was evaluated using mouse macrophages cell line (RAW cells). MC-IOPs were found to rapidly associate with the RAW cells, and saturation was typically reached within the 24 h of incubation at 37°C. Nearly 8.53 ± 0.31 pg iron/cell were bound or internalized at saturation. From these results, we conclude that MC-IOPs effectively deliver into RAW cells in vitro and we also …

Autoimmune-Induced Preferential Depletion Of Myelin-Associated Glycoprotein (Mag) Is Genetically Regulated In Relapsing Eae (B6 × Sjl) F1 Mice, Dusanka S. Skundric, Rujuan Dai, Vaagn L. Zakarian, Weili Zhou

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Experimental autoimmune encephalomyelitis (EAE) is commonly used to investigate mechanisms of autoimmune-mediated damage to oligodendrocytes, myelin, and axons in multiple sclerosis (MS). Four distinct autoimmune mechanisms with subsequently distinct patterns of demyelination have been recognized in acute MS lesions. EAE correlates for those distinct patterns of MS lesions are unknown. An excessive loss of myelin-associated glycoprotein (MAG), as a result of distal oligodendrogliopathy, is found exclusively in the subtype III lesion. We sought to answer if types of demyelination in acute lesions during onset and relapse of EAE can replicate the specific patterns observed in MS acute lesions. …

Making Sense Of Dietary Supplements: The Dietary Supplements Labels Database, Annette M. Healy

Library Scholarly Publications

This article describes the Dietary Supplements Labels Database, a new resource from the National Library of Medicine that integrates information from dietary supplement manufacturers, government agencies, and clinical research into an easy-to-use interface. This database contains information on more than 2,000 brands of dietary supplement and more than 800 active ingredients. This resource will greatly assist consumers and health care providers in evaluating the safety, efficacy, and quality of dietary supplements. Features of the resource will be described as well as the browse and search methods used to access the information.

Department Of Family Medicine And Public Health Sciences 2007 Annual Report, Wayne State University School Of Medicine, Department Of Family Medicine And Public Health Sciences

Annual Reports

2007 annual report includes: Greetings from the Chair, Maryjean Schenk; Meet the Faculty and Benefactors; Full-time Affiliate and Voluntary Faculty; Master of Public Health Program; Honors, Awards, and Appointments; Family Medicine Residency; Residency Community Activities; Patient Care at the Family Medicine Centers; Editorial; Research Highlights; Occupational and Environmental Health; External Funding; Highlights from 2007 Publications; Peer-Reviewed Publications; Faculty Development; Undergraduate Medical Education; Editorial and Peer-Review Activities; Presentations at Professional Meetings; Clinical and Community Translational Research; Professional Meetings Hosted; Faculty Involvement in Academic Service; Vision, Mission, and Core Values.

Functional Analysis Of Human Beta Defensin-1: Novel Insight Into Its Role In Prostate Cancer, Rebecca S. Bullard

MUSC Theses and Dissertations

Prostate cancer is the second leading cause of cancer-related deaths in men in the United States. The molecular pathogenesis of this disease includes genetic alterations, infection, and exposure to inflammatory or dietary oxidants. Recently, research has focused on the role of host defense peptides in tumor immunity. Defensins, a highly conserved multigene family of proteins that possess antimicrobial and antiviral properties, play an essential role in innate and adaptive immunity. These peptides are categorized into alpha- and beta-defensins based upon the spacing and connection between the six conserved cysteine residues of the mature peptide. Human Beta Defensin-1 (hBD-1), an important …

2008 Transactions, American Dental Association

ADA Transactions

This item is part of the Transactions of the ADA, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT). It is from the Transactions section, one of three subtitles that make up the full publication. Generally, the ADA Transactions are published in multiple volumes throughout the year. Pages from the Annual Reports and the Transactions are numbered consecutively (e.g. Annual Reports volume ends pg. 500 and Transactions volume starts at pg. 501). NOTE: All three subtitles are collectively known as the Transactions of the ADA or, alternatively, the ADA Transactions. Transactions refers …

2008 Supplement Vol. 3, American Dental Association

ADA Transactions

This item is part of the Supplements subtitle of The ADA Transactions, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT) made up of three separate subtitles: Annual Reports and Resolutions, Supplements, and the Transactions. Generally, The ADA Transactions are published in multiple volumes throughout the year. The Supplements function like an appendix and are, in more recent editions, numbered separately with page numbers determined by HOD reference committee assignation. Items are described variously as "Supplement #", "Volume #", etc. throughout the series but have been labeled here as Vol. # for …

Physician Assistant Class Of 2008, Philadelphia College Of Osteopathic Medicine

All Yearbooks

Includes the White Coat Ceremony, Classroom candids, Class outings, Fall Retreat 2006, Halloween Party 2006, Christmas Party 2006, Clinical Skills Lab, PCOM Prom 2007, Powderpuff Football 2007, PA Olympics 2007, Senior Fridays.

Synapsis: Philadelphia Campus (2008), Philadelphia College Of Osteopathic Medicine

All Yearbooks

This yearbook includes Military, OMM Fellows, DO Day on the Hill, White Coat Ceremony, Prom, Trips, Class Officers, Dr. Meals' Memorial.

Synthesis And In Vitro Characterization Of Novel Dextran- Methylprednisolone Conjugates With Peptide Linkers: Effects Of Linker Length On Hydrolytic And Enzymatic Release Of Methylprednisolone And Its Peptidyl Intermediates, Suman Penugonda, Anil Kumar, Hitesh K. Agarwal, Keykavous Parang, Reza Mehvar

Pharmacy Faculty Articles and Research

To control the rate of release of methylprednisolone (MP) in lysosomes, new dextran-MP conjugates with peptide linkers were synthesized and characterized. Methylprednisolone succinate (MPS) was attached to dextran 25 kDa using linkers with 1-5 Gly residues. The release characteristics of the conjugates in pH 4.0 and 7.4 buffers, blood, liver lysosomes, and various lysosomal proteinases were determined using a size-exclusion and/or a newly developed reversed-phase HPLC method capable of simultaneous quantitation of MP, MPS, and all five possible MPS-peptidyl intermediates. We synthesized conjugates with >= 90% purity and 6.9-9.5% (w/w) degree of MP substitution. The conjugates were stable at pH …

Emerging Trends In Cigarette Sales In Ohio During First Year Implementation Of The Smoking Ban, Megan Luse

Master of Public Health Program Student Publications

Objective: The Ohio smoking ban was passed by Ohio voters on November 7, 2006 and took effect on December 7, 2006. The reporting of violations to the Ohio smoking ban began on May 3, 2007 with the implementation of the civil penalties for the violations. The purpose of this study is to look at emerging trends in cigarette sales change from 2006 to 2007 for the 88 counties in Ohio following implementation of the smoking ban on December 7, 2006 based on geographical location, violation level, and tobacco production.

Methods: Data was obtained from Claritas for the 2006 aggregate expenditure …

Knowing While Growing: Occupational Therapy Interventions For Women With High-Risk Pregnancies, Rebecca Anderson, Cammie Vodicka

Occupational Therapy Capstones

High-risk pregnancy is a growing concern in the United States (McCormick, 2001), resulting in complications in both the mother and the fetus. Each year, approximately 875,000 women experience at least one complication. Approximately 460,000 women are receiving inadequate prenatal care (American Pregnancy Association, 2007). The purpose of Knowing While Growing: Occupational Therapy Interventions for Women with High-Risk Pregnancies is to promote the health and well ness of expectant mothers and to prevent disability to themselves and their developing fetus through the use of research-based therapeutic interventions. The components of this manual include definitions of high-risk pregnancies and related terms, information …

Helping To Win The Battle Within: An Occupational Therapy Perspective On Returning War Veterans With Ptsd And Employment, Christine Avikainen, Amber L. Harvey

Occupational Therapy Capstones

Approximately 300,000 individuals of the 1.64million servive members and veterans, from Operation Iraqi Freedom/Operation Enduring Freedom have been diagnosed with post traumatic stress disorder (PTSD) (Tanielian & Jaycox, 2008).

This scholarly project has addressed the needs of the increasing number of war veterans suffering from PTSD. The soldiers returning from the present war and their employers do not have adequate resources to understand symptoms related to PTSD and the effects on functioning.

A review of the literature revealed a lack of information for returning military personnel and the process of obtaining/reobtaining employment. The research provided evidence that employers and employees …

Occupational Therapy Perspective In The Management Of Lymphedema, Mellonna Beckermann

Occupational Therapy Capstones

Problem: Lymphedema is a collection of excess water, interstitial fluid, plasma proteins, bacteria, and cellular waste products in the interstitial tissues as a result of an impaired lymphatic system due to disease or trauma (Cheville, McGarvey, Petrek, Russo, Taylor, & Thiadens, 2003). This fluid typically collects in a person's upper and/or lower extremities. Lymphedema is a chronic condition and can be progressive if not managed properly. Lymphedema may result in significant impairments to the person, which results in functional limitations and a decrease in quality of life (Konecne & Perdoma, 2004). Treatment of lymphedema can be costly, timely, and overwhelming …

Bright Beginnings: Quick Tips For Occupational Therapists In The Level Ii Nursery, Lindsey Bartholomew, Lacey Gramstad

Occupational Therapy Capstones

In 2004 there were 790 infants born prematurely in Wyoming (Freudenthal, 2006). Currently, the highest level of infant care available in Wyoming is a Level II nursery. In Wyoming, infants born prematurely with special medical needs are typically transported to specialized NICU's in surrounding states. The limited contact that medical staff, including occupational therapists (OT's), in rural facilities have with critically or moderately ill infants creates a lack of competency with the unique medical care needs of the infants. According to Gordon (2003) "nearly half of America's babies start out their lives in a rural community" (p. 3). Furthermore, research …

Occupational Therapy Caregiver's Guide To Spinal Cord Injury, Kelsey Berg, Amanda Larson

Occupational Therapy Capstones

In 2006, it was estimated that there were 253,000 Americans living with spinal cord injuries (SCI) (Spinal Cord Injury Information Network, 2003, p. 1). Current literature suggests that individuals are transitioning into the community earlier with the majority of care being provided by informal caregivers (Boschen, Tonack, & Gargaro, 2005). These caregivers are often unprepared for the major role they will be assuming in the care of their loved one and often their health and well-being is compromised due to the overwhelming nature of caregiving.

A comprehensive literature review was conducted to explore and identify the needs of caregivers. Topics …

A Wellness Program For Adults With Developmental Disabilities, Kristina Bouley, Lynsey Schirado

Occupational Therapy Capstones

When researching wellness programs for adults with developmental disabilities, the authors found there to be several barriers to wellness for this population, with one of these barriers being physical activity. Many adults with developmental disabilities do not engage in adequate amounts of physical activity (Havercamp, Scandlin, and Roth, 2004). This may be impart to inadequate access to transportation to get to and from the fitness facility (Heller, Hsieh, & Rimmer, 2004; U.S. Public Health Service, 2001), the cost of joining a fitness facility program (Heller, Hsieh, & Rimmer, 2004; Temple & Walkley, 2007), or challenges in accessing fitness equipment (Heller, …