Medicine and Health Sciences Commons^™

Quantification De La Variabilité Biologique : Impact De La Variation Des Niveaux Ambiants De Contaminants, Ginette Truchon, Robert Tardif, Pierre-Olivier Droz, Philippe Nantel, Ginette Charest-Tardif, Alice De Batz

Rapports de recherche scientifique

Certaines caractéristiques liées à l’individu, aux contaminants, à la tâche ou au milieu de travail peuvent engendrer des variations importantes dans les niveaux biologiques retrouvés chez un individu pour un indicateur donné. Par le biais de la modélisation toxicocinétique à base physiologique et à base compartimentale, couplées à la simulation Monte-Carlo, la présente étude a documenté l’impact des fluctuations des niveaux ambiants des contaminants sur la valeur des indicateurs biologiques d’exposition documentés dans le Guide de surveillance biologique – Prélèvement et interprétation des résultats de l'IRSST. Cette étude propose également un modèle mathématique afin d’intégrer les différentes sources de variabilité, …

Lymphohistiocytic Proliferative Syndrome Of Alligators (Alligator Mississippiensis): A Cutaneous Manifestation Of West Nile Virus, Javier G. Nevarez

LSU Doctoral Dissertations

ABSTRACT In 1999, there were reports of a new type of lesion in the hides of captive reared alligators from Florida. Similar lesions were first reported from alligator hides in Louisiana in 2001; however, it wasn’t until 2002 that small epizootics became apparent. In 2002, the Louisiana Department of Wildlife and Fisheries began a collaborative effort with the Louisiana State University School of Veterinary Medicine (LSU SVM) to help elucidate the etiology of “PIX” disease, later renamed Lymphohistiocytic Proliferative Syndrome of Alligators (LPSA). Preliminary work concluded that LPSA was a systemic disease affecting multiple tissues. Based on the results of …

Young Adults And Health Insurance Coverage: A Description Of Trends, Christina Lynn Hansen

Honors Program Theses

Such high rates of uninsurance are due to many factors, but the transition from dependence to independence is a major cause of uninsurance within young adults. Affecting all classes and groups of young adults, it is shown that being in low-income families, a member of a minority group, and being male all increase chances of uninsurance (Callahan & Cooper, 2004).

Gastroesophageal Reflux Disease And Fundoplication In Infants And Children, Shawn D. St Peter, G W. Holcomb Iii

Manuscripts, Articles, Book Chapters and Other Papers

Gastroesophageal reflux disease (GERD) can be one of the most distressing conditions developing at different ages in infants and children. The disease itself is a complex process along with ongoing dynamic anatomic and physiologic changes occurring during normal development. Therefore among referring physicians, considerations regarding the role of surgery for GERD in children varies widely depending on individual experiences in managing these patients. These varied opinions result in discrepancies in the operative experience with fundoplication among pediatric surgeons. It is unclear how much of the current opinions stem from published evidence, particularly with regard to the safety and efficacy of …

Meeting The Interests Of Adolescent Females In Physical Education, Sarah Marie Huffer

Honors Program Theses

The purpose of this study is to compare the activities of interest of adolescent females in physical education with the types of activities that are provided in their present physical education curriculum at the representative high school. Creating a parallel between activities of interest and activities within physical education curriculums will provide females with more motivation to be physically active while in high school and after they graduate.

Hemicrania Continua-Like Headache Associated With Carotid Dissection May Respond To Indomethacin, Avi Ashkenazi, Muhammad A. Abbas, Dinesh K. Sharma, Stephen D. Silberstein

Department of Neurology Faculty Papers

Hemicrania continua (HC) is an idiopathic, chronic disorder characterized by a continuous, strictly unilateral headache associated with ipsilateral cranial autonomic symptoms. The symptoms of HC typically respond dramatically to indomethacin therapy. We describe a patient with traumatic internal carotid artery (ICA) dissection, who presented with a clinical picture mimicking HC that initially responded to indomethacin. Patients with a clinical picture similar to HC should be managed with a high index of suspicion for a possible cervical arterial dissection.

Evaluation Of A Community-Based Tuberculosis Screening Program For Latino Immigrants In New York City, Cristina R. Fernández

Public Health Theses

No abstract provided.

Department Of Pathology, Thomas Jefferson University, Identification Of Conserved Gene Expression Features Between Murine Mammary Carcinoma Models And Human Breast Tumors., Jason I Herschkowitz, Karl Simin, Victor J Weigman, Igor Mikaelian, Jerry Usary, Zhiyuan Hu, Karen E Rasmussen, Laundette P Jones, Shahin Assefnia, Subhashini Chandrasekharan, Michael G Backlund, Yuzhi Yin, Andrey I Khramtsov, Roy Bastein, John Quackenbush, Robert I Glazer, Powel H Brown, Jeffrey E Green, Levy Kopelovich, Priscilla A Furth, Juan P Palazzo, Olufunmilayo I Olopade, Philip S Bernard, Gary A Churchill, Terry Van Dyke, Charles M Perou

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Although numerous mouse models of breast carcinomas have been developed, we do not know the extent to which any faithfully represent clinically significant human phenotypes. To address this need, we characterized mammary tumor gene expression profiles from 13 different murine models using DNA microarrays and compared the resulting data to those from human breast tumors. RESULTS: Unsupervised hierarchical clustering analysis showed that six models (TgWAP-Myc, TgMMTV-Neu, TgMMTV-PyMT, TgWAP-Int3, TgWAP-Tag, and TgC3(1)-Tag) yielded tumors with distinctive and homogeneous expression patterns within each strain. However, in each of four other models (TgWAP-T121, TgMMTV-Wnt1, Brca1Co/Co;TgMMTV-Cre;p53+/- and DMBA-induced), tumors with a variety of …

Silencing Of The Pink1 Gene Expression By Conditional Rnai Does Not Induce Dopaminergic Neuron Death In Mice., Hongxia Zhou, Björn H Falkenburger, Jörg B Schulz, Kim Tieu, Zuoshang Xu, Xu Gang Xia

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Transgenic RNAi, an alternative to the gene knockout approach, can induce hypomorphic phenotypes that resemble those of the gene knockout in mice. Conditional transgenic RNAi is an attractive choice of method for reverse genetics in vivo because it can achieve temporal and spatial silencing of targeted genes. Pol III promoters such as U6 are widely used to drive the expression of RNAi transgenes in animals. Tested in transgenic mice, a Cre-loxP inducible U6 promoter drove the broad expression of an shRNA against the Pink1 gene whose loss-of-functional mutations cause one form of familial Parkinson's disease. The expression of the shRNA …

Continued Professional Competence And Portfolios, Michelle Byrne, Teresa Delarose, Cecil A. King, Jane Stover Leske, Kathryn G. Sapnas, Kathryn Schroeter

College of Nursing Faculty Research and Publications

It is traditionally assumed that licensure of healthcare professionals means that they are minimally competent. Many nursing specialty organizations offer examinations and other processes for certification, suggesting that certification is associated with continued competency. Can standardized examination for certification and continuing education for recertification ensure continued competency? Continuing education and testing provide a limited picture of an individual's knowledge and/or skill acquisition in a limited area at one point in time. However, portfolios promote critical thinking, self-assessment, and individual accountability. A portfolio is a portable mechanism for evaluating competencies that may otherwise be difficult to assess. This article summarizes some …

Advocacy: The Tool Of A Hero, Kathryn Schroeter

College of Nursing Faculty Research and Publications

No abstract provided.

Legislation And Policy Development, Kathryn Shisler Harrod, Lisa Hanson, Kathryn Osborne

College of Nursing Faculty Research and Publications

No abstract provided.

Effects Of Teaching Resourcefulness And Acceptance On Affect, Behavior, And Cognition Of Chronically Ill Elders, Jaclene Zauszniewski, Abir K. Bekhet, Chien-Yu Lai, Patricia Mcdonald, Carol M. Musil

College of Nursing Faculty Research and Publications

This clinical trial examined changes in affect, behavior, and cognition in 176 chronically ill elders who were randomly assigned to Resourcefulness Training (RT), Acceptance Training (AT), or Diversional Activities (DA). The RT group improved on affect (t(1,42) = 4.91; p < .001) and cognition (t(1,42) = 2.03; p< .05) and these effects lasted 12 weeks. The AT group improved on affect (t(1,36) = 3.08; p < .01), but this improvement did not persist. The RT and AT groups both showed positive behavior changes after six weeks. There were no changes in the DA group. The findings suggest that teaching elders resourcefulness and acceptance of chronic conditions may promote healthy functioning and improve their quality of life.

The Bath Environment, The Bathing Task, And The Older Adult: A Review And Future Directions For Bathing Disability Research, Susan L. Murphy, Kimberlee A. Gretebeck, Neil B. Alexander

College of Nursing Faculty Research and Publications

Purpose. To review existing research studies to identify optimal intervention strategies for remediation and prevention of bathing disability and future directions for bathing disability research.

Method. Bathing disability, defined as problems in the interaction between the person and the environment during bathing performance, is examined through a comprehensive, narrative literature review.

Results. Most studies focus on the relationship between the person and the environment (such as assistive device use and environmental hazards) while fewer studies focus on analysis of the bathing task or the interaction of the person, environment, and bathing task. Of intervention studies, most do …

The Influence Of Religiosity On Contraceptive Use And Abortion In The United States, Richard J. Fehring, Jennifer Ohlendorf

College of Nursing Faculty Research and Publications

The CDC has conducted the National Survey of Family Growth (NSFG) every three to seven years between 1973 and 2002 to describe contraceptive use among women in the U.S. The data from these surveys are available to researchers to examine trends in contraceptive use and sexual behaviors. The purpose of this study was to examine data from the 2002 NSFG in order to determine the influence of religiosity on abortion and abortifacient contraceptive use, i.e., the use of the oral contraceptive pill (OC), the injected hormone Depoprovera (IC), the IUD, and hormonal emergency contraception (EC), among American women between the …

Perceived Readiness For Hospital Discharge In Adult Medical-Surgical Patients, Marianne E. Weiss, Linda B. Piacentine, Lisa Lokken, Janice Ancona, Joanne Archer, Susan Gresser, Sue Holmes Baird, Sally Toman, Anne Toy, Teri Vega-Stromberg

College of Nursing Faculty Research and Publications

Purpose: The purpose of the study was to identify predictors and outcomes of adult medical-surgical patients' perceptions of their readiness for hospital discharge.

Design: A correlational, prospective, longitudinal design with path analyses was used to explore relationships among transition theory-related variables.

Setting: Midwestern tertiary medical center.

Sample: 147 adult medical-surgical patients.

Methods: Predictor variables included patient characteristics, hospitalization factors, and nursing practices that were measured prior to hospital discharge using a study enrollment form, the Quality of Discharge Teaching Scale, and the Care Coordination Scale. Discharge readiness was measured using the Readiness for Hospital Discharge Scale administered within 4 hours …

Increasing Serum 25-Hydroxyvitamin D As A Possible Deterrent To The Onset Of Multiple Sclerosis, Nicholas J. Perretti

Seton Hall University Dissertations and Theses (ETDs)

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Relation Between Anger And Depression And Predictors Of Anger Among Residents Of Assisted Living Facilities, Masami Tokumo

Seton Hall University Dissertations and Theses (ETDs)

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Molecular Mechanisms Of Olfactory Neurodegeneration, Radhika Anand Vaishnav

University of Kentucky Doctoral Dissertations

Olfactory sensory decline has been associated with normal aging as well as neurodegenerative disorders, yet the underlying mechanisms are unclear. The overall aim of this dissertation was to investigate the fundamental molecular and cellular mechanisms associated with olfactory neurodegeneration. This investigation uses an integrative approach, combining proteomics and gene expression analyses with cellular and tissuelevel characterization. Using these approaches, two model systems were investigated: 1) normally aging C57BL/6 mice of ages 1.5-, 6- and 20-months; and 2) a mouse model of elevated endogenous oxidative stress-associated neurodegeneration, namely, the Harlequin mutant mouse. The first specific aim was to test the hypothesis …

Resiliency In Adolescent College Students, Nancy Ahern

Electronic Theses and Dissertations

The construct of resilience has gained considerable attention over the last four decades since researchers observed that children and youth could cope and adapt in spite of adversity. Resilience involves a dynamic process involving an interaction between both risk and protective processes, internal and external to the individual, that can modify the effects of an adverse life event. Adolescence is considered to be a period of vulnerability for most individuals as they often partake in high risk behaviors. Further, those individuals who are in their early college years are faced with the developmental challenges of this life phase which can …

Guest Editorial, Greg Holzman

Michigan Journal of Public Health

No abstract provided.

Mennonite College Of Nursing Annual Report, 2006-2007, Mennonite College Of Nursing

Annual Reports - Mennonite College of Nursing

Annual report of the Mennonite College of Nursing at Illinois State University

Antioxidants And Pain Control In Patients With Chronic Pancreatitis: A Never-Ending Story, Raffaele Pezzilli, Lorenzo Fantini

Turkish Journal of Medical Sciences

Chronic pancreatitis is a benign disease often characterized by recurrent episodes of abdominal pain accompanied by progressive pancreatic exocrine and endocrine insufficiency; it sometimes requires multiple hospitalizations. This disease is frequently the result of chronic alcohol abuse, even if other factors such as genetic alterations, autoimmune disorders, and obstructive disease of the biliary tract and the pancreas may cause the disease. The pain can be considered the most important symptom; it significantly modifies the quality of life of patients with chronic pancreatitis and its control represents a challenge in the treatment of the disease. Among the several modalities for controlling …

Comparison Of The Antibacterial Effects Of Two Local Anesthetics: Lidocaine And Articaine, Kadi̇r Kaya, Seyyal Rota, Bora Doğan, Gi̇zem Kökten, Berri̇n Günaydin, Gülendam Bozdayi

Turkish Journal of Medical Sciences

Aim: The antibacterial effect of lidocaine has been studied widely, but the effect of articaine has not yet been evaluated. We aimed to investigate whether commercially available articaine possesses bactericidal or bacteriostatic effect in comparison with lidocaine in a prospective laboratory setting. Materials and Methods: The antibacterial effects of articaine and lidocaine were studied on Pseudomonas aeruginosa ATCC27853, Staphylococcus aureus ATCC25923, Escherichia coli ATCC35218, and Proteus mirabilis ATCC7002 strains and a patient isolate of Serratia marcescens. For this study, 2% lidocaine HCl and articaine HCl were diluted to 10, 5, 2.5, 1.25, 0.625, 0.312, 0.156, and 0.078 mg ml^{-1} concentrations …

Cobalamin Deficiency During Pregnancy Expressed As Elevated Urine Methylmalonic Acid Levels Determined By A Photometric Assay, Osman Meti̇n İpçi̇oğlu, Mustafa Gültepe, Ömer Özcan

Turkish Journal of Medical Sciences

Aim: Deficiency of cobalamin and folate during pregnancy is associated with megaloblastic anemia. Lower levels of folate and vitamin B12 were reported in mothers whose offspring had neural tube defects compared to unaffected controls. Increased methylmalonic acid (MMA) levels are a sensitive indicator of mild vitamin B12 deficiency and elevated homocysteine levels denote vitamin B12 or folate deficiency. We aimed to evaluate cobalamin state in pregnancy by using urine MMA levels determined by an economic spectrophotometric method. Materials and Methods: For this cross-sectional study, plasma total homocysteine (tHcy), serum folate and vitamin B12, and urine MMA levels were measured in …

K26 Antigen From L. Infantum Mon1: Sequence Based Function-Localization Analysis, Behrooz Darbani, Mahmoud Toorchi, Safar Farajnia, Seyyed Abolghasem Mohammadi, C. Neal Stewart

Turkish Journal of Medical Sciences

No abstract provided.

Diagnostic Performance Of Qus For Identifying Osteoporosis In Postmenopausal Turkish Women, Ayfer Gemalmaz, Güzel Di̇şci̇gi̇l, Cengi̇z Ceylan

Turkish Journal of Medical Sciences

Aim: The aims of this study were to evaluate the ability of quantitative ultrasound (QUS) to identify osteoporosis in postmenopausal women on the basis of dual-energy X-ray absorptiometry (DXA) T-scores, the best predictor of osteoporotic fractures, and to find a cut-off value for QUS with the optimum sensitivity and specificity, in order to select postmenopausal women for DXA referral. Materials and Methods: This study included 116 postmenopausal women attending Adnan Menderes University Family Medicine Clinic in Aydin. Bone density was measured at the calcaneus using QUS and at lumbar spine and femoral neck with DXA. Receiver operating characteristic analysis was …

Autopsy Status And Pathologists’ Attitude Towards Autopsy In Turkey, Kemal Kösemehmetoğlu, Ali̇ Riza Tümer, Alp Usubütün

Turkish Journal of Medical Sciences

Aim: While there have been efforts to slow the recent declining trend in autopsy practice in the world, in Turkey there is already a low level of medical autopsy audit, practically nearing zero. In this study, we determine and evaluate the autopsy status in Turkey; reveal pathologists' attitudes towards autopsy practice; propose several factors to explain current autopsy audit; and discuss differences in Turkey's autopsy practice with that of the rest of the world. Materials and Methods: We directed a questionnaire to 85 pathologists and requested autopsy numbers from 50 universities for the period 1995 to 2003. Results: Mean values …

Long-Arm Splinting For Lateral Epicondylitis: A Case Study, Crystal Wolters

Masters Theses

Lateral epicondylitis is a debilitating condition that has a significantly negative effect on the occupational lives of many people. There appears to be no recognized ideal treatment method for the condition. Long-arm splinting for lateral epicondylitis has not been addressed in the literature. A case study was used to thoroughly describe one participant’s experience with long-arm splinting to treat her lateral epicondylitis. She was interviewed, observed, and measurements were taken of her affected arm’s range of motion and strength. The seven themes which were identified through these methods include a description of how her lateral epicondylitis developed, her description of …

Attitudes Of Nurses Toward Research, Nancee Hofmeister

Masters Theses

The purpose of this study was to examine the attitudes of nurses toward research. Donabedian’s framework of structure, process and outcome is the conceptual model. A convenience sample (n=119) of registered nurses at a Midwest hospital answered Boothe’s Attitudes on Nursing Research Scale. The scale contains 84-items answered on a 5-point Likert scale. The scores were analyzed using descriptive statistics, t-tests, and ANOVA. Comparisons were made of the top and bottom quartile of item scores. The results indicate items that reflect structure and process are a subscale of the interest and environment scale. The most positive attitudes of the nurses …