Medicine and Health Sciences Commons^™

Estimating Health Utilities And Quality Adjusted Life Years In Seasonal Affective Disorder Research, Michael C. Freed, Kelly J. Rohan, Brian T. Yates

Uniformed Services University of the Health Sciences

Background: Seasonal affective disorder (SAD) episodes will recur annually without effective intervention. Effectiveness of such interventions is traditionally measured with depression-specific tools (e.g., Beck Depression Inventory 2nd Edition; BDI-II). In a climate of potentially scarce resources, generic outcomes, such as Quality Adjusted Life Years (QALYs), are recommended for cost-effectiveness research. For treatments to be deemed cost-effective, they must show effectiveness relative to each other and relative to interventions across other disorders. To date, QALYs have not been used to determine effectiveness of SAD treatments. Given the recurrent nature of SAD, QALYs, which weight quality of life with time, are an …

Biodosepr-2006 Consensus Committee Report On Biodosimetric Methods To Evaluate Radiation Doses At Long Times After Exposure, Steven L. Simon, Ian Bailiff, André Bouville, Paola Fattibene, Ruth A. Kleinerman, David C. Lloyd, Stephen W.S. Mckeever, Alexander Romanyukha, Alexander V, Sevan’Kaev, James D. Tucker, Albrecht Wieser

Uniformed Services University of the Health Sciences

The requirements for biodosimetric techniques used at long times after exposure, i.e., 6 months to more than 50 years, are unique compared to the requirements for methods used for immediate dose estimation. In addition to the fundamental requirement that the assay measures a physical or biologic change that is proportional to the energy absorbed, the signal must be highly stable over time to enable reasonably precise determinations of the absorbed dose decades later. The primary uses of these biodosimetric methods have been to support long-term health risk (epidemiologic) studies or to support compensation (damage) claims. For these reasons, the methods …

Reduced Migration, Altered Matrix And Enhanced Tgfβ1 Signaling Are Signatures Of Mouse Keratinocytes Lacking Sdc1, Mary Ann Stepp, Yueyuan Liu, Sonali Pal-Ghosh, Rosalyn A. Jurjus, Gauri Tadvalka, Adith Sekaran, Kristen Losicco, Li Jiang, Melinda Larsen, Luowei Li, Stuart H. Yuspa

Biological Sciences Faculty Scholarship

We have reported previously that syndecan-1 (Sdc1)-null mice show delayed re-epithelialization after skin and corneal wounding. Here, we show that primary keratinocytes obtained from Sdc1-null mice and grown for 3-5 days in culture are more proliferative, more adherent and migrate more slowly than wt keratinocytes. However, the migration rates of Sdc1-null keratinocytes can be restored to wild-type levels by replating Sdc1-null keratinocytes onto tissue culture plates coated with fibronectin and collagen I, laminin (LN)-332 or onto the matrices produced by wild-type cells. Migration rates can also be restored by treating Sdc1-null keratinocytes with antibodies …

Baylor History Of Medicine Society Schedule 2007-2008, Baylor Hisotry Of Medicine Society

Houston History of Medicine Lectures (2006-2012)

• "Medicine: Perspectives in History and Art" (Robert E. Greenspan)
• Eight Practical Lessons from Osler That Will Better Your Life (Bryan Boutwell)
• History of the American Mental Hospital: From networking to not working & Back (Ed Fann)
• Ambiguities and Amputations: Methods, mishaps, and the surgical quest to cure breast cancer (Student Essay Contest Winner) (Matt Luedke)
• An Automated, Algorithmic, Retrospective Analysis of the Growing Influence of Statistics in Medicine (Student Essay Contest Winner) (Ryan Rochat)
• What’s Special about William Osler? (Charles S. Bryan)
• The Virtuous Physician: Lessons from Medical Biography (Charles S. Bryan)
• Legacy: 50 Years of Loving Care – The …

State Agency Promising Practices: Employment First! Making Integrated Employment The Preferred Outcome In Tennessee, Jean Winsor, Thinkwork! At The Institute For Community Inclusion At Umass Boston

ThinkWork! Publications

The Tennessee Division of Mental Retardation Services (DMRS) implemented the Employment First! initiative in 2002. The goal of Employment First was to make employment the first day service option for adults receiving supports funded by DMRS, Medicaid, or the state. Employment First set the standard that employment was the preferred service option for adults with mental retardation and developmental disabilities (MR/DD).

State Agency Promising Practice: Shifting Resources Away From Sheltered Workshops In Vermont, Jennifer Sullivan Sulewski, Thinkwork! At The Institute For Community Inclusion At Umass Boston

ThinkWork! Publications

Over six years, regulations in Vermont gradually restricted and eventually prohibited the use of state funds for sheltered workshops or enclaves. Concurrent with the change in funding regulations, the state worked with providers to convert the remaining sheltered workshops in Vermont.

State Agency Promising Practice: Working Together To Convert The Last Sheltered Workshop In Vermont To Individualized Supports, Jennifer Sullivan Sulewski, Thinkwork! At The Institute For Community Inclusion At Umass Boston

ThinkWork! Publications

Vermont’s Division of Disability and Aging Services (DDAS) and Division of Vocational Rehabilitation (DVR) worked with a local service provider to convert its congregate day services to community employment. Implementation Between 1987 and 2002, DDAS and DVR worked with several providers to close down sheltered workshops and move people into community supports.

State Agency Promising Practice: Integrated Employment Outcomes Through Person-To-Person Technical Assistance: New Hampshire, Allison C. Hall, Thinkwork! At The Institute For Community Inclusion At Umass Boston

ThinkWork! Publications

New Hampshire implemented an innovative technical assistance model that promoted organizational change to expand individual employment opportunities. This person-to-person change began at the micro level but “trickled up” through organizations across the state. In 2000, realizing that the state’s growth in integrated employment had stalled, the Bureau of Developmental Services invested aggressively in expanding its intervention strategy by recruiting a community provider to work directly through the bureau. The bureau hired John Vance-the director of ACCESS, a small individualized support organization in New Hampshire-half-time to provide individualized technical assistance to providers across the state. As part of the bureau, Vance …

State Agency Promising Practices: Washington State’S Working-Age Adult Policy, Allison C. Hall, Thinkwork! At The Institute For Community Inclusion At Umass Boston

ThinkWork! Publications

Washington’s Division of Developmental Disabilities (DDD) has recently issued a new policy which went into full effect on July 1, 2006. This policy “designates employment supports as the primary method of furnishing state-financed day services to adult participants.” Emphasizing community employment as the primary service option, the policy further states that: “services for persons under the age of 62 that do not emphasize the pursuit or maintenance of employment in integrated settings can be authorized only by exception to policy” (WA DHSH, DDD, “County Services for Working Age Adults” Policy 4.11). Initially adopted in 2004, this policy does not eliminate …

State Agency Promising Practice: The Tennessee Employment Consortium (Tec) - A Statewide Collaboration For Change, Jean Winsor, Thinkwork! At The Institute For Community Inclusion At Umass Boston

ThinkWork! Publications

The Tennessee Employment Consortium (TEC) is a statewide organization focused on increasing the number of Tennesseans in integrated employment. The consortium comprises volunteers from the state’s Division of Mental Retardation Services (DMRS) and Division of Rehabilitation Services (DRS), the Tennessee Council on Developmental Disabilities, the ARC of Tennessee, the Center on Disability and Employment at the University of Tennessee, community rehabilitation providers (CRPs), family members, and other stakeholders. TEC’s ability to organize collaborative activities across state agencies, advocacy organizations, and CRPs has played an important role in increasing integrated employment outcomes.

Ocpat: An Online Codon-Preserved Alignment Tool For Evolutionary Genomic Analysis Of Protein Coding Sequences, Guozhen Liu, Monica Uddin, Munirul Islam, Morris Goodman, Lawrence I. Grossman, Roberto Romero, Derek E. Wildman

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Rapidly accumulating genome sequence data from multiple species offer powerful opportunities for the detection of DNA sequence evolution. Phylogenetic tree construction and codon-based tests for natural selection are the prevailing tools used to detect functionally important evolutionary change in protein coding sequences. These analyses often require multiple DNA sequence alignments that maintain the correct reading frame for each collection of putative orthologous sequences. Since this feature is not available in most alignment tools, codon reading frames often must be checked manually before evolutionary analyses can commence.

Results

Here we report an online codon-preserved alignment tool (OCPAT) that generates …

Whole Genome Expression Profiling Reveals A Significant Role For Immune Function In Human Abdominal Aortic Aneurysms, Guy M. Lenk, Gerard Tromp, Shantel Weinsheimer, Zoran Gatalica, Ramon Berguer, Helena Kuivaniemi

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Abdominal aortic aneurysms are a common disorder with an incompletely understood etiology. We used Illumina and Affymetrix microarray platforms to generate global gene expression profiles for both aneurysmal (AAA) and non-aneurysmal abdominal aorta, and identified genes that were significantly differentially expressed between cases and controls.

Results

Affymetrix and Illumina arrays included 18,057 genes in common; 11,542 (64%) of these genes were considered to be expressed in either aneurysmal or normal abdominal aorta. There were 3,274 differentially expressed genes with a false discovery rate (FDR) ≤ 0.05. Many of these genes were not previously known to be involved in …

Repressor Element-1 Silencing Transcription Factor/Neuronal Restrictive Silencer Factor (Rest/Nrsf) Can Regulate Hsv-1 Immediate-Early Transcription Via Histone Modification, Rajeswara C. Pinnoji, Gautam R. Bedadala, Beena George, Thomas C. Holland, James M. Hill, Shao-Chung V. Hsia

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

During primary infection of its human host, Herpes Simplex Virus Type-1 (HSV-1) establishes latency in neurons where the viral genome is maintained in a circular form associated with nucleosomes in a chromatin configration. During latency, most viral genes are silenced, although the molecular mechanisms responsible for this are unclear. We hypothesized that neuronal factors repress HSV-1 gene expression during latency. A search of the HSV-1 DNA sequence for potential regulatory elements identified a Repressor Element-1/Neuronal Restrictive Silencer Element (RE-1/NRSE) located between HSV-1 genes ICP22 and ICP4. We predicted that the Repressor Element Silencing Transcription Factor/Neuronal Restrictive Silencer Factor …

Socioeconomic Position And Incident Mobility Impairment In The Cardiovascular Health Study, Cheryl K. Nordstrom, Ana V. Diez Roux, Richard Schulz, Mary N. Haan, Sharon A. Jackson, Jennifer L. Balfour

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

We investigated if personal socioeconomic position (SEP) factors and neighborhood characteristics were associated with incident mobility impairment in the elderly.

Methods

We used data from the Cardiovascular Health Study, a longitudinal, population-based examination of coronary heart disease and stroke among persons aged 65 and older in the United States.

Results

Among 3,684 persons without baseline mobility impairment, lower baseline SEP was associated with increased risk of incident mobility disability during the 10-year follow-up period, although the strengths of these associations varied by socioeconomic indicator and race/sex group.

Conclusion

Among independent-living elderly, SEP affected development of mobility impairment into …

An Unusual Presentation Of Adenoid Cystic Carcinoma Of The Minor Salivary Glands With Cranial Nerve Palsy: A Case Study, Amal Abdul-Hussein, Pierre A. Morris, Tsveti Markova

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Adenoid Cystic Carcinoma (ACC) is a rare tumor entity and comprises about 1% of all malignant tumor of the oral and maxillofacial region. It is slow growing but a highly invasive cancer with a high recurrence rate. Intracranial ACC is even more infrequent and could be primary or secondary occurring either by direct invasion, hematogenous spread, or perineural spread. We report the first case of the 5^th and 6^th nerve palsy due to cavernous sinus invasion by adenoid cystic carcinoma.

Case presentation

A 49-year-old African American female presented to the emergency room complaining of severe right-sided …

Pediatricians' Attitudes, Experience And Referral Patterns Regarding Complementary/Alternative Medicine: A National Survey, Anju Sawni, Ronald Thomas

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

To assess pediatricians' attitudes toward & practice of Complementary/Alternative Medicine (CAM) including their knowledge, experience, & referral patterns for CAM therapies.

Methods

An anonymous, self-report, 27-item questionnaire was mailed nationally to fellows of the American Academy of Pediatrics in July 2004.

648 of 3500 pediatricians' surveyed responded (18%).

Results

The median age ranged from 46–59 yrs; 52% female, 81% Caucasian, 71% generalists, & 85% trained in the US. Over 96% of pediatricians' responding believed their patients were using CAM. Discussions of CAM use were initiated by the family (70%) & only 37% of pediatricians asked about CAM use …

Comparison Of The Systemic And Pulmonary Inflammatory Response To Endotoxin Of Neutropenic And Non-Neutropenic Rats, Sabrina M. Heidemann, Maria Glibetic

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Neutrophil infiltration commonly occurs in acute lung injury and may be partly responsible for the inflammatory response. However, acute lung injury still occurs in the neutropenic host. The objectives of this study are to determine if inflammation and acute lung injury are worse in neutropenic versus the normal host after endotoxemia.

Methods

Rats were divided into four groups: 1) control, 2) neutropenic, 3) endotoxemic and 4) endotoxemic and neutropenic. Tumor necrosis factor (TNF)-α and macrophage inflammatory protein (MIP-2) were measured in the blood, lung lavage and for mRNA in the lung. Arterial blood gases were measured to determine …

Immunohistochemical Diagnosis Of Aspergillosis In Adult Turkeys, Enver Beytut

Turkish Journal of Veterinary & Animal Sciences

The aim of the present study was to apply immunohistochemistry, using a commercially available monoclonal antibody, for the diagnosis of aspergillosis in adult turkeys. Eight adult turkeys were studied. The lungs revealed grossly a few yellowish-white granulomas. Histopathologically, the granulomas were distributed in the pulmonary parenchyma or occasionally located around the airways. A few fungal hyphae were detected within the necrotic debris of the granulomas in the lungs using routine fungal stains. Immunohistochemical staining performed on lung sections from all of the turkeys disclosed fungal hyphae and their fragments clearly within the necrotic debris and within the cytoplasm of macrophages …

Influence Of Bovine Somatotropin And Replacement Of Corn Dextrose With Concentrate On The Performance Of Mid-Lactating Buffaloes Fed Urea-Treated Wheat Straw, Muhammad Sarwar, Muhammad Asif Shahzad, Mahr-Un Nisa, Aboubakar Sufyan

Turkish Journal of Veterinary & Animal Sciences

The study examined the effect of bovine somatotropin (bST) in mid-lactating Nili-Ravi buffaloes (n = 18) given varying levels of Enzose (corn dextrose) in a urea-treated wheat straw (UTWS) based ration on nutrient intake, digestibility, nitrogen (N) utilisation, milk yield, and its composition in a completely randomised design with a 2 x 3 factorial arrangement. The control ration contained 60% UTWS and 40% concentrate. The other 2 rations were formulated to replace 50% or 100% concentrate portions of the ration with Enzose of equivalent energy. Enzose is a liquid derived from the enzymatic conversion of corn starch to dextrose, and …

Modelling The Protein And Amino Acid Requirements Of The Greater Rhea (Rhea Americana), James Sales

Turkish Journal of Veterinary & Animal Sciences

Protein and amino acid requirements of the Greater rhea (Rhea americana) have been estimated from growth data available for this species, and assumptions derived with other closely related species. Differences in body weight and growth pattern caused considerable higher protein and amino acid requirements for males compared to females after 3 months of age. Whereas the absolute protein requirement is comparable between males (148 g/day) and females (144.5 g/day) at 50 days of age, 21.8 g/day protein is needed by males at 500 days of age compared to 12.2 g/day for females. Limitations include the lack of knowledge on feed …

Physical Activity And Physical Activity Adherence In The Elderly Based On Smoking Status., Theodore Cooper, M. Resor, C. Stoever, P. Dubbert

Departmental Papers (Psych)

No abstract provided.

An Outpatient Physical Therapy Non-Operative Management And Intervention For An Older, Athletic, Professional, Caucasian Male Patient With An Acute Gastrocnemius Medialis And Lateralis Muscle Rupture, Thea Loy Pallansch

Physical Therapy Scholarly Projects

Description: The gastrocnemius muscle is a two joint muscle originating on the femur and inserting into the calcaneus through the Achilles tendon. The gastrocnemius spans the knee and ankle joint providing important stabilization and movement functions in walking, running, and jumping activities. Rupture of the Achilles tendon is one of the most common tendinous injuries. Non-operative, conservative treatment of the acute Achilles tendon rupture demonstrates comparable results to surgical intervention. Non-operative management promotes patient tolerance, low cost, and positive clinical outcomes. Previous studies have supported the concept of functional bracing as a conservative, alternate treatment for an acutely ruptured Achilles …

2007 Transactions, American Dental Association

ADA Transactions

This item is part of the Transactions of the ADA, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT). It is from the Transactions section, one of three subtitles that make up the full publication. Generally, the ADA Transactions are published in multiple volumes throughout the year. Pages from the Annual Reports and the Transactions are numbered consecutively (e.g. Annual Reports volume ends pg. 500 and Transactions volume starts at pg. 501). NOTE: All three subtitles are collectively known as the Transactions of the ADA or, alternatively, the ADA Transactions. Transactions refers …

2007 Annual Reports And Resolutions, American Dental Association

ADA Transactions

This item is part of the Annual Reports and Resolutions subtitle of the ADA Transactions, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT) made up of three separate subtitles: Annual Reports and Resolutions, Supplements, and Transactions. Generally, the ADA Transactions are published in multiple volumes throughout the year. Older versions include reports from all departments as subsections, while more recent versions include only those of councils, commissions, and committees.

2007 Supplement Vol. 1, American Dental Association

ADA Transactions

This item is part of the Supplements subtitle of The ADA Transactions, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT) made up of three separate subtitles: Annual Reports and Resolutions, Supplements, and the Transactions. Generally, The ADA Transactions are published in multiple volumes throughout the year. The Supplements function like an appendix and are, in more recent editions, numbered separately with page numbers determined by HOD reference committee assignation. Items are described variously as "Supplement #", "Volume #", etc. throughout the series but have been labeled here as Vol. # for …

2007 Supplement Vol. 2, American Dental Association

ADA Transactions

This item is part of the Supplements subtitle of The ADA Transactions, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT) made up of three separate subtitles: Annual Reports and Resolutions, Supplements, and the Transactions. Generally, The ADA Transactions are published in multiple volumes throughout the year. The Supplements function like an appendix and are, in more recent editions, numbered separately with page numbers determined by HOD reference committee assignation. Items are described variously as "Supplement #", "Volume #", etc. throughout the series but have been labeled here as Vol. # for …

The Impact Of The User Board Majority Requirement On The Governance Of Community Health Centers, Nancy J. Bracken

MUSC Theses and Dissertations

The federal requirement that 51 percent of the governing boards of federally funded community health centers must be users of the health center was originally intended to insure that the community served had a voice in the services provided. This qualitative study attempted to determine the perceptions of key stakeholders of the impact of the requirement on the effectiveness of governing boards, as well as how boards develop and measure effectiveness. Open-ended, semi-structured interviews with five CEOs and five Board Chairs revealed few concerns about the challenges of complying with the requirement. Board training in South Carolina appears to be …

Measuring Safety Culture In A Non-Us Airline Using The Commercial Aviation Safety Survey, Terry L. Von Thaden, Sólveig Ragnarsdóttir

International Symposium on Aviation Psychology - 2007

The purpose of this present study was twofold: firstly to test the psychometric appropriateness of the Commercial Aviation Safety Survey (CASS) for flight operations developed at the University of Illinois, in non-US environment, and secondly to assess the current state of organizational safety culture at a European airline. To achieve these objectives the CASS was administered in a web-based format to the flight operations department at a major European air carrier. The respondents reflected a representative employee distribution and a response rate of 31 percent. The internal consistency of the CASS indicated adequate reliability (all scores above 0.70). The survey …

An Airline Evaluation Of The Facilitation Skills Assessment Tool [Fsat] As A Device For Training And Assessing Facilitators, Maryjo O. Smith Ph.D., Guy M. Smith Ed.D., Captain Colin Budenberg, Captain John Willats, Captain Pete Griffiths

International Symposium on Aviation Psychology - 2007

Researchers and airline practitioners from the USA and UK collaborated in a four-year project to develop the Facilitation Skills Assessment Tool (FSAT), an instrument to assess the skills of an airline facilitator. The final phase of the FSAT Development Project was the evaluation of FSAT at two airlines – Thomsonfly (formerly Britannia Airways) in the UK and Southwest Airlines in the USA. Statistical analysis allowed the combination of data from both airlines; these 66 assessments demonstrated that FSAT was a valid and reliable instrument for measuring facilitation skills.

Changes In Cognitive And Sensory Abilities Of Older Pilots Parallel Those Observed In The General Population, C.A. Miller, A. Chaparro

International Symposium on Aviation Psychology - 2007

This investigation compares young and older pilots with age-matched controls from the general population on cognitive and sensory abilities. Cognitive assessments included short-term and long-term memory, learning, delayed recognition and mental rotation. Sensory measures included visual acuity, contrast sensitivity, auditory thresholds, speech intelligibility and tactile sensitivity. Significant differences in contrast sensitivity was obtained as a function of age and pilot status. Also, young pilots (24-42 years) have greater tactile sensitivity than older pilots (64-88 years), and both non-pilot groups. In general, younger participants performed better on the assessments than the older subjects regardless of pilot status. Although, the mean differences …