Medicine and Health Sciences Commons^™

Facilitation By Drug States Does Not Depend On Acquired Excitatory Strength, Matthew I. Palmatier, Rick A. Bevins

Department of Psychology: Faculty Publications

Three experiments examined the effects of drug-extinction when a drug state served as a conditional stimulus (CS) for sucrose delivery or as a positive feature for pairings between a discrete CS (e.g., 15-s light-on) and sucrose. Some conditioning models predict that drug-state will facilitate the conditional response (CR) based on an association with sucrose whether the drug is trained as a CS or as a facilitator. If so, repeated presentation of the drug state alone (drug-extinction) should decrease the CR in both situations. Nicotine (0.4 mg/kg), amphetamine (AMP, 1 mg/kg), and chlordiazepoxide (CDP, 5 mg/kg) facilitated a goal-tracking conditioned response …

Ada News - 01/22/2007, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

The Myc Transactivation Domain Promotes Global Phosphorylation Of The Rna Polymerase Ii Carboxy-Terminal Domain Independently Of Direct Dna Binding, Victoria H. Cowling, Michael D. Cole

Dartmouth Scholarship

Myc is a transcription factor which is dependent on its DNA binding domain for transcriptional regulation of target genes. Here, we report the surprising finding that Myc mutants devoid of direct DNA binding activity and Myc target gene regulation can rescue a substantial fraction of the growth defect in myc^−/− fibroblasts. Expression of the Myc transactivation domain alone induces a transcription-independent elevation of the RNA polymerase II (Pol II) C-terminal domain (CTD) kinases cyclin-dependent kinase 7 (CDK7) and CDK9 and a global increase in CTD phosphorylation. The Myc transactivation domain binds to the transcription initiation sites of these promoters …

The Scholarship Of Teaching: A Dream For The Future, Ruth-Marie Fincher

Health Professions Educational Research Symposium

No abstract provided.

Developing & Implementing An Educational Research Agenda, Gail Jensen

Health Professions Educational Research Symposium

Moderator: Dr. Mary Blackinton

Developing & Implementing An Educational Research Agenda, Elizabeth Hoppe

Health Professions Educational Research Symposium

Moderator: Dr. Mary Blackinton

Forecasting The Global Burden Of Alzheimer's Disease, Ron Brookmeyer, Elizabeth Johnson, Kathryn Ziegler-Graham, H. Michael Arrighi

Johns Hopkins University, Dept. of Biostatistics Working Papers

Background: The goal was to forecast the global burden of Alzheimer’s disease and evaluate the potential impact of interventions that delay disease onset or progression. Methods: A stochastic multi-state model was used in conjunction with U.N. worldwide population forecasts and data from epidemiological studies on risks of Alzheimer’s disease.

Findings: In 2006 the worldwide prevalence of Alzheimer’s disease was 26.6 million. By 2050, prevalence will quadruple by which time 1 in 85 persons worldwide will be living with the disease. We estimate about 43% of prevalent cases need a high level of care equivalent to that of a nursing home. …

Naltrexone Renders One-Session Exposure Therapy Less Effective: A Controlled Pilot Study, Andrea T. Kozac, C. Richard Spates, Dennis E. Mcchargue, Katherine C. Bailey, Kristin L. Schneider, Michael R. Liepman

Department of Psychology: Faculty Publications

In vivo exposure has become the gold standard treatment for specific phobia. The endogenous opioid system is one mechanism proposed to explain why exposure provides such quick and effective treatment for specific phobia. The effect of naltrexone on fear and avoidance behavior was investigated among 15 specific phobia participants who received exposure treatment. Participants were randomly assigned to receive naltrexone, placebo, or no drug prior to attending one-session exposure treatment. Mixed effects regression results revealed that across time, the naltrexone group tolerated significantly less time in the room with the feared animal (Behavioral Avoidance Index) as compared to the placebo …

Final Report Technical Assistance To Improve Quality Oversight Of The Oklahoma Advantage Waiver, Maureen Booth, Louise Olsen

Disability & Aging

No abstract provided.

Neurophysiologic And Behavioral Measures Of Phonetic Perception In Adult Second Language Speakers Of Spanish, Jaden D. Hellewell

Theses and Dissertations

Infants 6-8 months old are able to identify nearly every speech sound contrast on which they have been tested, regardless of whether that contrast represents an across-category (two different phonemes) phonetic change in their native language or not. A child's ability to identify non-native consonant contrasts greatly diminishes by 11-12 months of age. The present study examined speech sound discrimination in three groups of listeners. Adult second language (L2) listeners of Spanish were compared with native English listeners with no knowledge of Spanish and native Mexican listeners to determine if they would show the ability to discriminate phonetic distinctions that …

Estimating The Empirical Lorenz Curve And Gini Coefficient In The Presence Of Error, Chaya S. Moskowitz, E. S. Venkatraman, Elyn Riedel, Colin B. Begg

Memorial Sloan-Kettering Cancer Center, Dept. of Epidemiology & Biostatistics Working Paper Series

The Lorenz curve is a graphical tool that is widely used to characterize the concentration of a measure in a population, such as wealth. It is frequently the case that the measure of interest used to rank experimental units when estimating the empirical Lorenz curve, and the corresponding Gini coefficient, is subject to random error. This error can result in an incorrect ranking of experimental units which inevitably leads to a curve that exaggerates the degree of concentration (variation) in the population. We explore this bias and discuss several widely available statistical methods that have the potential to reduce or …

Catatonia Yesterday, Today, Tomorrow, Amresh Srivastava

Psychiatry Presentations

No abstract provided.

Genetic Protection Against Hepatitis B Virus Conferred By Ccr5Δ32: Evidence That Ccr5 Contributes To Viral Persistence, Chloe L. Thio, Jacquie Astemborski, Arman A. Bashirova, Timothy L. Mosbruger, Spencer Greer, Mallory D. Witt, James J. Goedert, Margaret Hilgartner, Audrey Majesk, Stephen J. O'Brien, David L. Thomas, Mary Carrington

Biology Faculty Articles

Recovery from acute hepatitis B virus (HBV) infection requires a broad, vigorous T-cell response, which is enhanced in mice when chemokine receptor 5 (CCR5) is missing. To test the hypothesis that production of a nonfunctional CCR5 (CCR5Δ32 [a functionally null allele containing a 32-bp deletion]) increases the likelihood of recovery from hepatitis B in humans, we studied 526 persons from three cohorts in which one person with HBV persistence was matched to two persons who recovered from an HBV infection. Recovery or persistence was determined prior to availability of lamivudine. We determined genotypes forCCR5Δ32 …

Phosphorylation Of The Proline-Rich Domain Of Xp95 Modulates Xp95 Interaction With Partner Proteins, Robert E Dejournett, Ryuji Kobayashi, Shujuan Pan, Chuanfen Wu, Laurence D Etkin, Richard B Clark, Oliver Bögler, Jian Kuang

Faculty, Staff and Student Publications

The mammalian adaptor protein Alix [ALG-2 (apoptosis-linked-gene-2 product)-interacting protein X] belongs to a conserved family of proteins that have in common an N-terminal Bro1 domain and a C-terminal PRD (proline-rich domain), both of which mediate partner protein interactions. Following our previous finding that Xp95, the Xenopus orthologue of Alix, undergoes a phosphorylation-dependent gel mobility shift during progesteroneinduced oocyte meiotic maturation, we explored potential regulation of Xp95/Alix by protein phosphorylation in hormone-induced cell cycle re-entry or M-phase induction. By MALDI-TOF (matrix-assisted laser-desorption ionization-time-of-flight) MS analyses and gel mobility-shift assays, Xp95 is phosphorylated at multiple sites within the N-terminal half of the …

Phosphorylation Of The Proline-Rich Domain Of Xp95 Modulates Xp95 Interaction With Partner Proteins, Robert E Dejournett, Ryuji Kobayashi, Shujuan Pan, Chuanfen Wu, Laurence D Etkin, Richard B Clark, Oliver Bögler, Jian Kuang

Faculty, Staff and Student Publications

The mammalian adaptor protein Alix [ALG-2 (apoptosis-linked-gene-2 product)-interacting protein X] belongs to a conserved family of proteins that have in common an N-terminal Bro1 domain and a C-terminal PRD (proline-rich domain), both of which mediate partner protein interactions. Following our previous finding that Xp95, the Xenopus orthologue of Alix, undergoes a phosphorylation-dependent gel mobility shift during progesteroneinduced oocyte meiotic maturation, we explored potential regulation of Xp95/Alix by protein phosphorylation in hormone-induced cell cycle re-entry or M-phase induction. By MALDI-TOF (matrix-assisted laser-desorption ionization-time-of-flight) MS analyses and gel mobility-shift assays, Xp95 is phosphorylated at multiple sites within the N-terminal half of the …

Provider Adherence To Jnc 7 Guidelines And Blood Pressure Outcomes In African Americans, Rosalind Peters, Ramona Benkert, Karyn Butler

Peer Reviewed Articles

Objective: To measure provider adherence with the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) and assess whether adherence is associated with improved blood pressure (BP) control among low-income African-American patients.

Design: Chart review.

Setting and participants: A primary care clinic for low-income patients within an urban, university health center. Data were obtained from charts of 128 hypertensive African-American patients enrolled in a larger study.

Measures: The Hypertension Quality Chart Review Index was used to measure adherence in the areas of cardiovascular risk assessment, lifestyle modification, pharmacologic treatment, and …

Intravenous Saline Administration Improves Physical Functioning., Travis L. Stiles, Staci R. Stevens, Christopher R. Snell, Lucinda Bateman, J. Mark Van Ness

College of the Pacific Faculty Presentations

ABSTRACT Patients with Chronic Fatigue Syndrome (CFS) have diminished physical capacity that has been linked to low blood volume (hypovolemia) and abnormal sympathoadrenal activation. Intravenous saline administration could ameliorate these problems, thereby improving the work capacity in CFS. Purpose: This study investigates the effect of 1 L/day of 0.9% saline administration in a 37 yr old female with CFS. Methods: Primary outcome measures were based on cardiopulmonary responses during maximal exercise testing. A preliminary exercise test was performed prior to beginning saline administration. Follow-up exercise tests were conducted at 15, 55, 92, 125, 180, 248, 317, 420 and 675 days …

The Fate Of The Unexpected Positive Intraoperative Cultures After Revision Total Knee Arthroplasty, Robert L. Barrack, Ajay Aggarwal, R. Stephen J. Burnett, John C. Clohisy, Elie Ghanem, Peter Sharkey, Javad Parvizi

Department of Orthopaedic Surgery Faculty Papers

Of a consecutive series of 692 revision total knees at 3 centers, intraoperative cultures were unexpectedly found to be positive in 41 cases (5.9%). Of the 41, 29 (71%) cases had a single positive intraoperative culture and were determined to be a probable false positive based on absence of any other evidence of infection, of which 5 were treated with extended course of intravenous antibiotics after hospital discharge and the remaining 24 received no further treatment. None of these 24 patients manifested any sign of infection at follow-up, averaging 46 months (range, 24-74 months). Twelve patients were determined to have …

Ada News - 01/08/2007, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Beta Blocker Specificity: A Building Block Toward Personalized Medicine., Brent R Degeorge, Walter J Koch

Center for Translational Medicine Faculty Papers

Drugs known as beta blockers, which antagonize the beta-adrenergic receptor (beta-AR), are an important component of the treatment regimen for chronic heart failure (HF). However, a significant body of evidence indicates that genetic heterogeneity at the level of the beta(1)-AR may be a factor in explaining the variable responses of HF patients to beta blockade. In this issue of the JCI, Rochais et al. describe how a single amino acid change in beta(1)-AR alters its structural conformation and improves its functional response to carvedilol, a beta blocker currently used in the treatment of HF (see the related article beginning on …

Intellectual Property Management In Health And Agricultural Innovation: A Handbook Of Best Practices, Vol. 2, Anatole Krattiger, Richard T. Mahoney, Lita Nelsen, Jennifer A. Thomson, Alan B. Bennett, Kanikaram Satyanarayana, Gregory D. Graff, Carlos Fernandez, Stanley Kowalski

Law Faculty Scholarship

Prepared by and for policy-makers, leaders of public sector research establishments, technology transfer professionals, licensing executives, and scientists, this online resource offers up-to-date information and strategies for utilizing the power of both intellectual property and the public domain. Emphasis is placed on advancing innovation in health and agriculture, though many of the principles outlined here are broadly applicable across technology fields. Eschewing ideological debates and general proclamations, the authors always keep their eye on the practical side of IP management. The site is based on a comprehensive Handbook and Executive Guide that provide substantive discussions and analysis of the opportunities …

Glycaemic Index, Glycaemic Load And Risk Of Endometrial Cancer: A Prospective Cohort Study, Stephanie A. Navarro Silvera, Thomas E. Rohan, Meera Jain, Paul D. Terry, Geoffrey R. Howe, Anthony B. Miller

Department of Public Health Scholarship and Creative Works

Objective

High-glycaemic-load diets may increase endometrial cancer risk by increasing circulating insulin levels and, as a consequence, circulating oestrogen levels. Given the paucity of epidemiological data regarding the relationship between the dietary glycaemic index and glycaemic load and endometrial cancer risk, we sought to examine these associations using data from a prospective cohort study.

Design, setting, and subjects

We examined the association between dietary glycaemic load and endometrial cancer risk in a cohort of 49 613 Canadian women aged between 40 and 59 years at baseline who completed self-administered food-frequency questionnaires between 1982 and 1985. Linkages to national mortality and …

A Member Of The Novel Fikk Family Of Plasmodium Falciparum Putative Protein Kinases Exhibits Diacylglycerol Kinase Activity And Is Exported To The Host Erythrocyte, David Floyd Curtis

Electronic Theses and Dissertations

Plasmodium falciparum is one of four species known to cause malaria in humans and is the species that is associated with the most virulent form of the disease. Malaria causes nearly two million deaths each year, many of these occurring among children in under-developed countries of the world. One reason for this is the prevalence of drug resistant strains of malaria that mitigate the efficacy of existing drugs. Hence, the identification of a new generation of pharmacological agents for malaria is extremely urgent. The recent identification of a group of novel protein kinases within the Plasmodium falciparum genome has provided …

Caduceus 2007, Stritch School Of Medicine

Stritch School of Medicine Yearbooks

No abstract provided.

Nursing Theory And Knowledge Development: A Descriptive Review Of Doctoral Dissertations, 2000–2004, Hila Spear

Faculty Publications and Presentations

Within the profession of nursing, nursing theory, conceptual models, and knowledge development continue to be points of discussion and debate. Some suggest that nursing research must either test or develop nursing theory, whereas others believe that research germane to practice can legitimately incorporate what is commonly referred to as borrowed theory. This descriptive analysis of nursing doctoral dissertations (N = 207) conducted from 2000 to 2004 focused primarily on the inclusion or exclusion of nursing theories. Almost half (45.4%) of the dissertations studied theories from fields other than nursing, 27.1% of the researchers studied nursing theories, and 27.5% of the …

Developmental Risks And Psychosocial Adjustment Among Low-Income Brazilian Youth, Marcela Raffaelli, Silvia H. Koller, Elder Cerqueria-Santos, Normanda Araujo De Morais

Department of Psychology: Faculty Publications

Exposure to developmental risks in three domains (community, economic, and family), and relations between risks and psychosocial well-being, were examined among 918 impoverished Brazilian youth aged 14-19 (M = 15.8 years, 51.9% female) recruited in low-income neighborhoods in one city in Southern Brazil. High levels of developmental risks were reported, with levels and types of risks varying by gender, age, and (to a lesser extent) race. Associations between levels of risks in the various domains and indicators of psychological (e.g., self-esteem, negative emotionality) and behavioral (e.g., substance use) adjustment differed for male and female respondents. Findings build on prior …

Energy In-Energy Out: A Balanced Equation?, Kathleen M. Laquale

Movement Arts, Health Promotion and Leisure Studies Faculty Publications

The article reports that many athletes are not ingesting an adequate number of calories from their diets. Fat and lean body mass become the sources for fuel for energy and this leads to lack of tissue growth. Exercise physiologists have calculated energy intake and energy expenditure metrics with recommendations.

Why Look At A Food Label?, Kathleen M. Laquale

Movement Arts, Health Promotion and Leisure Studies Faculty Publications

The article presents information on reading food labels to assist athletes in making better food choices. It discusses the six components required to appear on labels by the U.S. Food and Drug Administration (FDA), including product identity, net contents or number of servings per container, and the ingredient list. The key recommendations of the 2005 Dietary Guidelines for Americans are presented. Daily values as an expression of a food's nutrient content are discussed.

Nutritional Concerns For Ethnically Diverse Athletes, Kathleen M. Laquale

Movement Arts, Health Promotion and Leisure Studies Faculty Publications

The article discusses the variety of international nutritional guidelines, comparing the food guide pyramid of the United States to similar constructs such as the Chinese food guide pagoda. Athletic therapists are advised to consider culinary differences between cultures when advising ethnically diverse athletes on nutritional issues.

Red Bull: The Other Energy Drink And Its Effect On Performance, Kathleen M. Laquale

Movement Arts, Health Promotion and Leisure Studies Faculty Publications

The article reports on Red Bull energy drink and its effectiveness. It is created with synthetic ingredients which are stated to be the best quality available from pharmaceutical companies. Caffeine is one of the key ingredients which is normally not found in sports energy drinks. The limited research concludes that taurine and glucuronolactone in Red Bull have not been proven to improve body functions.