Medicine and Health Sciences Commons^™

Radiation Injury Is A Potentially Serious Complication To Fluoroscopically-Guided Complex Interventions, Lk Wagner

Faculty, Staff and Student Publications

Radiation-induced injury to skin is an infrequent but potentially serious complication to complex fluoroscopically-guided interventional procedures. Due to a lack of experience with such injuries, the medical community has found fluoroscopically-induced injuries difficult to diagnose. Injuries have occurred globally in many countries. Serious injuries most frequently occur on the back but have also occurred on the neck, buttocks and anterior of the chest. Severities of injuries range from skin rashes and epilation to necrosis of the skin and its underlying structures. This article reviews the characteristics of these injuries and some actions that can be taken to reduce their likelihood …

Exercise Adherence: Motivational Factors Influencing Exercise Adherence And Fitness Level, Justin Recklau

Undergraduate Theses and Capstone Projects

There are many factors that influence adherence to an exercise program. This research study aimed to determine which factors most effectively ensured adherence, with the hypothesis that no single factor was indicative of exercise adherence as adherence is a dynamic item. The results target exercise professionals to assist them in retaining clientele and encouraging clientele to adhere to exercise programs. A survey was implemented that had clients self-report their stage in the transtheoretical model as well as how strongly they felt about five positive factors to exercise as well as five barriers to exercise. In addition to surveys, body composition, …

A Two-Hour Basketball Practice Increases Landing Error Scoring System Scores In Female Collegiate Basketball Players, Caroline Wesley

Undergraduate Theses and Capstone Projects

The high rate of knee injuries in women’s athletics has been well documented in recent years. There are multiple factors which contribute to the increased risk of injury in female athletes, including biomechanics when landing. Fatigue has also been examined as a contributing factor to injury, but few studies have utilized actual sport participation as a fatiguing protocol. No study has used the Landing Error Scoring System (LESS) to examine the changes that may result from fatigue. The objective of our study was to use the LESS to examine the effects of a two-hour basketball practice on the landing biomechanics …

Downstream Pathway Activation In Cultured Hepatocytes Following Treatment With Francisella Tularensis, Nicole Wakefield

Undergraduate Theses and Capstone Projects

Francisella tularensis, the intracellular pathogen that causes tularemia, was investigated to determine how it infects and replicates within mammalian hepatocytes. To date, it has been shown that hepatocytes can be infected by F. tularensis and that this causes considerable change in the protein phosphorylation state of several vital signaling molecules within the host cell. Protein kinase pathways can be mapped as signatures of infection. Hepatocytes tend to be susceptible to infection by F. tularensis, thus stimulating internal signaling. The Francisella strains used were selected with the goal of producing a model that can be used to elucidate the cell signaling …

Interaction Between Cell Division Proteins Ftse And Ftsz, Brian D Corbin, Yipeng Wang, Tushar K Beuria, William Margolin

Faculty, Staff and Student Publications

FtsE and FtsX, which are widely conserved homologs of ABC transporters and interact with each other, have important but unknown functions in bacterial cell division. Coimmunoprecipitation of Escherichia coli cell extracts revealed that a functional FLAG-tagged version of FtsE, the putative ATP-binding component, interacts with FtsZ, the bacterial tubulin homolog required to assemble the cytokinetic Z ring and recruit the components of the divisome. This interaction is independent of FtsX, the predicted membrane component of the ABC transporter, which has been shown previously to interact with FtsE. The interaction also occurred independently of FtsA or ZipA, two other E. coli …

Effects Of Tooth Whitening Use On Oral Health Interests And Values In Adults, Katie Jo Ballantyne Sargent

Dental Hygiene Theses & Dissertations

The primary purpose of this study was to determine if tooth whitening product use influences oral health interests and values in an adult population. A two-group, randomized, pre-test, multiple post-test design was used for studying 60 adults between the ages of 18 and 60. Persons who use tobacco products, have composite/tooth-colored anterior restorations, less than eight anterior teeth, pregnant or lactating women, or those who have previously used a whitening product other than toothpaste were excluded from the study. At baseline, a researcher-designed Oral Health Questionnaire was administered to consenting adults to determine the level of oral health interests and …

A Comparative Study Of Learning Styles And Job Satisfaction To Medical Specialty Chosen Among Physician Assistant Graduates, Eric H. Vangsnes

Dissertations

Since the mid-1980s, a trend has developed whereby Physician Assistants (PAs) are making a transition into medical and surgical specialties (Hooker, 1992). In 1984, 18% of PAs worked in medical and surgical specialties; by 1991, this proportion had risen to 22%; and by 2006, 43% of all PAs worked in medical and surgical specialties ( American Academy of Physician Assistants (AAPA) Census Data 2006 , 2007; Hooker, 1992). One development that may have increased the number of PAs entering specialties was the creation of post-graduate residency programs.

This research examined possible associations between learning style and medical specialty, medical specialty …

The Topography Of Healing From East To West, Brandi Sullivan

Student Research Conference Select Presentations

No abstract provided.

Examinations Of Future Time Perspective, Self Determination Theory, And Self-Talk As Correlates Of Exercise Behavior, Thomas Desena

Student Research Conference Select Presentations

No abstract provided.

A Study Of Environmental Factors Influencing Obesity In The Workplace, Jagdish Khubchandani, Crystal Rowland

Student Research Conference Select Presentations

A research project that aims to conduct focus groups in an industrial setting which will provide information to design surveys on “employees perceptions of environmental factors that influence obesity at workplace”

Attentional Focus, Intensity, & Level Of Expertise, Diana Gieske, Melissa Abo, Dustin Strupp

Student Research Conference Select Presentations

No abstract provided.

A Proposal Of A Cinematography For A Fictional Documentary On The Semiological Manifestation Of A Place Called Death Valley, Emmett D. Barton

Student Research Conference Select Presentations

No abstract provided.

Group Production Manipulations Influence Decision Criteria In Group Brainstorming, Bryan Thomas Hall, Brandy Johnson

Student Research Conference Select Presentations

No abstract provided.

Motor Interference On Memory Tasks, Brandy Johnson

Student Research Conference Select Presentations

No abstract provided.

37th Annual Wku Student Research Conference, Student Research Council, Western Kentucky University

Student Research Conference Select Presentations

No abstract provided.

Perceived Purpose Of Midterm Evaluations And The Effect On Student Responses, Andrew Caudill

Student Research Conference Select Presentations

No abstract provided.

Trends In Particulate Matter And Mortality: An Approach To The Assessment Of Unmeasured Confounding, Holly Janes, Francesca Dominici, Scott Zeger

Johns Hopkins University, Dept. of Biostatistics Working Papers

We propose a method for diagnosing confounding bias under a model which links a spatially and temporally varying exposure and health outcome. We decompose the association into orthogonal components, corresponding to distinct spatial and temporal scales of variation. If the model fully controls for confounding, the exposure effect estimates should be equal at the different temporal and spatial scales. We show that the overall exposure effect estimate is a weighted average of the scale-specific exposure effect estimates.

We use this approach to estimate the association between monthly averages of fine particles (PM2.5) over the preceding 12 months and monthly mortality …

Caring For People With Alzheimer's Disease Or Dementia In Maine, Stuart Bratesman Mpp, Julie T. Fralich Mba, Catherine Mcguire Bs, Louise Olsen, Romaine Turyn

Disability & Aging

It is clear that caring for people with Alzheimer’s disease and dementia is a growing public health issue. Alzheimer’s is a progressively deteriorating disease that can last anywhere from 1 to 15 years. Families are the primary caregivers and will continue to need support to manage the care of their loved ones, to coordinate services within the long term care system and to maintain their own health and well-being.

Restraint-Induced Corticosterone Secretion And Hypothalamic Crh Mrna Expression Are Augmented During Acute Withdrawal From Chronic Cocaine Administration, John R. Mantsch, Sarah Taves, Tayyiba Khan, Eric S. Katz, Tanveer Sajan, Lee C. Tang, William E. Cullinan, Dana R. Ziegler

Biomedical Sciences Faculty Research and Publications

Stress responses during cocaine withdrawal likely contribute to drug relapse and may be intensified as a consequence of prior cocaine use. The present study examined changes in stressor-induced activation of the hypothalamic–pituitary–adrenal (HPA) axis during acute withdrawal from chronic cocaine administration. Adult male Sprague–Dawley rats received daily administration of cocaine (30 mg/kg, i.p.) or saline for 14 days. Twenty-four hours after the last injection, rats in each group were sacrificed under stress-free conditions or following 30 min of immobilization. Plasma corticosterone (CORT) was measured in trunk-blood using radioimmunoassay, corticotropin-releasing hormone (CRH) mRNA levels in the paraventricularnucleus (PVN) of the hypothalamus …

Crystal Structure Of The Anabaena Sensory Rhodopsin Transducer, Lutz Vogeley, Vishwa D Trivedi, Oleg A Sineshchekov, Elena N Spudich, John L Spudich, Hartmut Luecke

Faculty, Staff and Student Publications

We present crystal structures of the Anabaena sensory rhodopsin transducer (ASRT), a soluble cytoplasmic protein that interacts with the first structurally characterized eubacterial retinylidene photoreceptor Anabaena sensory rhodopsin (ASR). Four crystal structures of ASRT from three different spacegroups were obtained, in all of which ASRT is present as a planar (C4) tetramer, consistent with our characterization of ASRT as a tetramer in solution. The ASRT tetramer is tightly packed, with large interfaces where the well-structured beta-sandwich portion of the monomers provides the bulk of the tetramer-forming interactions, and forms a flat, stable surface on one side of the tetramer (the …

Food Facilities, Food Service Workers And The Flow Of Food: Food-Borne Illnesses In Taiwan's Preschools, Shu-Chen Lin

Graduate Student Dissertations, Theses, Capstones, and Portfolios

This study examined food-borne illnesses in Taiwan's preschools which are a major cause of personal distress and preventable death. They are of particular concern in preschools as very young children are highly susceptible to food-borne illnesses. Previous studies that comprehensively investigated the factors impacting food-borne illnesses in Taiwan were not found in the literature. The development of a universal food safety model is necessary as a means to measure relevant constructs. Application of the model should be able to prevent the occurrence of food-borne illnesses in organizations. This explanatory (correlational) study examined the relationships among food facilities, food service workers, …

Health Care Price Transparency And Price Competition, Mark Merlis

National Health Policy Forum

Growing numbers of consumers are in health plans that give them incentives to be more cost-conscious. Yet complex pricing systems and limited information may make it hard to choose among providers and treatment options. This report examines steps that insurers and others have taken to make better price information available, possible government measures to further promote price transparency or to simplify price comparisons, and the likely effects on consumer behavior and provider competition.

Some Of The Problems Associated With Lcn (Low Copy Number) Testing, Dan E. Krane

Biological Sciences Faculty Publications

No abstract provided.

Shp-2 Tyrosine Phosphatase Inhibits P73-Dependent Apoptosis And Expression Of A Subset Of P53-Target Genes Induced By The Green Tea Polyphenol Egcg, Arm R. Amin, Vijay S. Thakur, Rajib K. Paul, Gen Sheng Feng, Cheng-Kui Qu, Hasan Muktar, Munna L. Agarwal

Pharmaceutical Science and Research

Green tea polyphenol, epigallocatechin-3-gallate (EGCG) differentially regulates the cellular growth of cancer cells in a p53-dependent manner through apoptosis and/or cell cycle arrest. In an effort to further elucidate the mechanism of differential growth regulation by EGCG, we have investigated the role of the tyrosine phosphatase, SHP-2. Comparing the responses of mouse embryonic fibroblasts (MEFs), expressing either WT or functionally inactive/truncated SHP-2, we find that inactivation of SHP-2 remarkably sensitizes cells to EGCG-mediated killing. MEFs lacking functional SHP-2 undergo massive apoptosis upon treatment with EGCG. By comparing gene expression profiles, we have identified a set of transcriptional targets of p53 …

Transitioning From Acute Care To Ambulatory Care, Beth Ann Swan

College of Nursing Faculty Papers & Presentations

Trends in health care financing and changes in care delivery from the hospital to outpatient settings have caused an unprecedented demand for registered nurses in ambulatory care.

Nurses transition to ambulatory care expecting to use the same knowledge base and skill set used in their acute care practice.

While some knowledge and skills may be transferable, competencies (and additional knowledge and skills) needed by acute care nurses and ambulatory care nurses are not the same.

The purpose of this article to is describe and dispel myths associated with ambulatory care nursing practice and discuss the knowledge, skills, and competencies that …

An Essential Role Of Human Ada3 In P53 Acetylation., Alo Nag, Aleksandra Germaniuk-Kurowska, Manjari Dimri, Michael A. Sassack, Channabasavaiah B. Gurumurthy, Qingshen Gao, Goberdhan Dimri, Hamid Band, Vimla Band

Journal Articles: Biochemistry & Molecular Biology

The p53 tumor suppressor protein functions as a critical component of genotoxic stress response by regulating the expression of effector gene products that control the fate of a cell following DNA damage. Unstressed cells maintain p53 at low levels through regulated degradation, and p53 levels and activity are rapidly elevated upon genotoxic stress. Biochemical mechanisms that control the levels and activity of p53 are therefore of great interest. We and others have recently identified hAda3 (human homologue of yeast alteration/deficiency in activation 3) as a p53-interacting protein and enhancer of p53 activity. Here, we show that endogenous levels of p53 …

Finding The Fastest Way To Her Heart: Linking Clinical And Policy Pathways, Paula Johnson, Brian R. Schuetz, Shelley M. Stark, Dora Tovar

New England Journal of Public Policy

The Mary Horrigan Connors Center for Women’s Health and Gender Biology at Brigham and Women’s Hospital in Boston, integrates research, clinical practice, and policy analysis with practical application to emerging women’s health issues. Recently, an interdisciplinary team of practitioners examined pathways to improving women’s heart health. Beginning with the evidence that a heart-healthy diet leads to improved health outcomes for women with cardiovascular disease, the Connors Center team charted a course of intellectual exploration that culminated in a broader community dialogue on how to improve access to healthy and affordable food. Through clinical experiences, research activities, and an ongoing interchange …

Effects Of Low Dose Gm-Csf On Microglial Inflammatory Profiles To Diverse Pathogen-Associated Molecular Patterns (Pamps)., Nilufer Esen, Tammy Kielian

Journal Articles: Pathology and Microbiology

BACKGROUND: It is well appreciated that obtaining sufficient numbers of primary microglia for in vitro experiments has always been a challenge for scientists studying the biological properties of these cells. Supplementing culture medium with granulocyte-macrophage colony-stimulating factor (GM-CSF) partially alleviates this problem by increasing microglial yield. However, GM-CSF has also been reported to transition microglia into a dendritic cell (DC)-like phenotype and consequently, affect their immune properties.

METHODS: Although the concentration of GM-CSF used in our protocol for mouse microglial expansion (0.5 ng/ml) is at least 10-fold less compared to doses reported to affect microglial maturation and function (>/= …

Developing Social Work’S Self-Efficacy Model Of Student Assessment, Yvonne Unrau, Melinda Mccormick

Assessment Grants

No abstract provided.

Ada News - 03/19/2007, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.